FlyBase Gene Report: Dmel\RpL37-2

General Information

Symbol

Dmel\RpL37-2

Species

D. melanogaster

Name

Ribosomal protein L37-2

Annotation Symbol

CG9873

Feature Type

protein_coding_gene

FlyBase ID

FBgn0034822

Gene Model Status

Current

Stock Availability

3 publicly available

Gene Summary

Binds to the 23S rRNA. (UniProt, Q9W1U6)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

RpL37b

Key Links

Genomic Location

Cytogenetic map

59C4-59C4

Sequence location

2R:23,100,057..23,100,478 [-]

Recombination map

2-102

RefSeq locus

NT_033778 REGION:23100057..23100478

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000080456

(GO Reference Genome Project, 2011-)

enables structural constituent of ribosome

inferred from electronic annotation with InterPro:IPR001569, InterPro:IPR011331, InterPro:IPR018267

(InterPro Project Members, 2004-)

traceable author statement

(Marygold et al., 2007)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cytoplasmic translation

traceable author statement

(Marygold et al., 2007)

involved_in translation

inferred from sequence model

(FlyBase Curators, 2011-)

inferred from electronic annotation with InterPro:IPR001569, InterPro:IPR011331, InterPro:IPR011332, InterPro:IPR018267

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of cytosolic large ribosomal subunit

traceable author statement

(Marygold et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000080456

(GO Reference Genome Project, 2011-)

located_in ribosome

inferred from electronic annotation with InterPro:IPR001569, InterPro:IPR011331, InterPro:IPR018267

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS

Protein Family (UniProt)

Belongs to the eukaryotic ribosomal protein eL37 family. (Q9W1U6)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CYTOPLASMIC LARGE RIBOSOMAL PROTEINS -: Cytoplasmic ribosomes are found on the endoplasmic reticulum and in the cytoplasm. They translate all mRNAs produced from nuclear genes and perform the majority of cellular protein synthesis. Ribosomes are formed by two ribonucleoprotein subunits, large and small. The principle function of the large subunit is to bind tRNA during the synthesis of polypeptides. (Adapted from FBrf0205398).

Protein Function (UniProtKB)

Binds to the 23S rRNA.

(UniProt, Q9W1U6)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\RpL37-2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W1U6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

6XU6
6XU7

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

RpL37-2-RA

FBtr0071978

NM_137913

422

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

RpL37-2-PA

FBpp0071888

10.2

12.22

Q9W1U6

NP_611757

AAF46957

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

6XU6
6XU7

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W1U6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\RpL37-2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RpL37b_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.53

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\RpL37-2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\RpL37-2

View exonic expression by tissue for Dmel\RpL37-2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0034822

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37669/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034822

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034822

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034822

Flygut - An atlas of the Drosophila adult midgut

FBgn0034822

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of RpL37-2

Transgenic constructs containing regulatory region of RpL37-2

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2R)Exel7177

(Marygold et al., 2007, Ryder, 2004.4.26)

Df(2R)vir130

(Marygold et al., 2007)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

RpL37-2^GD15186

viable, with Scer\GAL4^Mef2.PR

RpL37-2^GD15186

viable, with Scer\GAL4^pnr-MD237

RpL37-2^GD15186

viable, with Scer\GAL4^tin.CΔ4

RpL37-2^GD15186

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

RpL37-2^GD15186

Phenotype manifest in

Allele

trichogen cell, with Scer\GAL4^pnr-MD237

RpL37-2^GD15186

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\RPL37

10 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\LOC100360841

10 of 14

Yes

9 of 14

8 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC100360654

1 of 14

Yes

Rnor\LOC102556290

1 of 14

Yes

Rnor\LOC103693118

1 of 14

Yes

Rnor\RGD1561310

1 of 14

Yes

Rnor\Rpl37-ps1

1 of 14

Yes

Mus musculus (laboratory mouse) (33)

Mmus\Rpl37

10 of 14

Yes

8 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\rpl37

6 of 13

Yes

Xtro\tecta.1

5 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (32)

Drer\kcna1a

1 of 14

Yes

Drer\kcna4

1 of 14

Yes

Drer\kcna6a

1 of 14

Yes

Drer\kcna7

1 of 14

Yes

Drer\kcnb2a

1 of 14

Yes

Drer\kcnb2b

1 of 14

Yes

Drer\kcnc1a

1 of 14

Yes

Drer\kcnc1b

1 of 14

Yes

Drer\kcnc2

1 of 14

Yes

Drer\kcnc3a

1 of 14

Yes

Drer\kcnc4

1 of 14

Yes

Drer\kcnd1

1 of 14

Yes

Drer\kcnd2

1 of 14

Yes

Drer\kcnf1a

1 of 14

Yes

Drer\kcng2

1 of 14

Yes

Drer\kcng4a

1 of 14

Yes

Drer\kcng4b

1 of 14

Yes

Drer\kcnq1.1

1 of 14

Yes

Drer\kcnq3

1 of 14

Yes

Drer\kcnq5a

1 of 14

Yes

Drer\kcnq5b

1 of 14

Yes

Drer\kcns3a

1 of 14

Yes

Drer\kcns3b

1 of 14

Yes

Drer\kcnv1

1 of 14

Yes

Drer\kcnv2a

1 of 14

Yes

Drer\kcnv2b

1 of 14

Yes

Drer\LOC100537363

1 of 14

Yes

Drer\LOC100537815

1 of 14

Yes

Drer\rpl37

1 of 14

Yes

Drer\si:ch73-334d15.4

1 of 14

Yes

Drer\si:dkey-43k4.5

1 of 14

Yes

Drer\si:rp71-39b20.4

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\rpl-37

13 of 14

Yes

Cele\W01D2.1

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP000952

7 of 12

Yes

Agam\AgaP_AGAP011501

6 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\AT1G15250

12 of 13

Yes

Atha\AT1G52300

12 of 13

Yes

Atha\AT3G16080

12 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\RPL37A

12 of 13

Yes

Scer\RPL37B

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\rpl3702

11 of 12

Yes

Spom\rpl3703

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:RpL37-2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (7)

11 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

RPL37; ribosomal protein L37

10 of 14

604181

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0034822

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

Class of Gene

nuclear_gene

protein_coding_gene

retrogene

(dos Santos, 2014, Zhang et al., 2011, Zhang et al., 2010, Bai et al., 2007, Langille and Clark, 2007, Dai et al., 2006, Betran et al., 2002)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-102

Cytogenetic map

59C4-59C4

Sequence location

2R:23,100,057..23,100,478 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

59C4-59C4

Limits computationally determined from genome sequence between P{PZ}l(2)06496⁰⁶⁴⁹⁶&P{lacW}l(2)k09913^k09913 and P{lacW}l(2)k07136^k07136

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-102

(FlyBase, 2016)

2-106.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (3)

Aberrations including deletions of this gene Aberrations including duplications of this gene

FlyORF

F001461

M{UAS-RpL37-2.ORF}ZH-86Fb

NIG-Fly

2RG-0189

y² VhaAC39-1^cho-1 v¹; P{U6-RpL37-2.NIG.sgRNA}attP40/CyO

VDRC

v29760

w¹¹¹⁸; P{GD15186}v29760

Genomic Clones (20)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI06520

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0034822

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0034822

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Hopes et al., 2022)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Not a Minute gene.

(Marygold et al., 2007)

Deletions removing RpL37b but no other cytoplasmic ribosomal protein-encoding genes do not show Minute phenotypes.

(Marygold et al., 2007)

Likely retrogene.

(Marygold et al., 2007)

Relationship to Other Genes

Source for database merge of

Additional comments

The RpL37b gene may have been derived from the RpL37a gene by retroposition.

(Chen et al., 2012, Zhang et al., 2011, Langille and Clark, 2007, Langille and Clark, 2007, Marygold et al., 2007, Dai et al., 2006)

The RpL37b gene may have been derived from the RpL37a gene by retroposition sometime after the divergence of the Sophophora and Drosophila subgenera.

(Zhang et al., 2010)

The RpL37b gene may have been derived from the RpL37A gene by retroposition.

(Bai et al., 2007)

The RpL37b gene may be derived from the RpL37a gene by retroposition.

(Betran et al., 2002)

Nomenclature History

Source for database identify of

Source for identity of: RpL37b CG9873

(Ashburner and Marygold, 2004.7.2)

Source for identity of: RpL37-2 RpL37b

(FlyBase, 2009-)

Nomenclature comments

Changed gene symbol 'RpL37b' to 'RpL37-2' following the change to the gene symbol of the paralogous gene 'RpL37a' to 'RpL37-1' to eliminate the case-insensitive duplication with the 'RpL37A' gene symbol.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

CG9873

(National Institute of Genetics Fly Stocks, 2022-, Schertel et al., 2013, Chen et al., 2012, Zhang et al., 2011, Zhang et al., 2011, Chen et al., 2010, Zhang et al., 2010, Zhang et al., 2010, Bai et al., 2008, Marygold et al., 2007, Dai et al., 2006, Wang et al., 2004, Betran et al., 2002)

RpL37-2

RpL37b

(Pang et al., 2023, Hopes et al., 2022, Liu et al., 2022, Polymenis, 2020, Rust et al., 2020, dos Santos, 2014, Sytnikova et al., 2014, Schertel et al., 2013, Bai et al., 2008, Bai et al., 2007, Langille and Clark, 2007, Langille and Clark, 2007, Marygold et al., 2007)

Rpl37b

(Bai et al., 2007, Bai et al., 2007)

Name Synonyms

Ribosomal protein L37-2

Ribosomal protein L37b

(Ashburner and Marygold, 2004.7.2)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 29 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37669

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF46957

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W1U6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9W1U6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W1U6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0034822

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37669/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0034822

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0034822

FlyMine - An integrated database for Drosophila genomics

FBgn0034822

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG9873

MARRVEL_MODEL - MARRVEL (model organism gene)

37669

PDB - An information portal to biological macromolecular structures

6XU6
6XU7

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0034822

DroID - A comprehensive database of gene and protein interactions.

FBgn0034822

DRSC - Results frm RNAi screens

FBgn0034822

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

RpL37b_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0034822

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0034822

Flygut - An atlas of the Drosophila adult midgut

FBgn0034822

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012363

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ribosome

References (49)

The following external sites may use different assemblies or annotations than FlyBase.

4.53

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