Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Klp59C using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Klp59C in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with RNAi against Klp59C do not show a significant change in poleward flux rates of tubulin subunits in mitotic spindles and do not show a significant change in α-tubulin turnover at the microtubule plus or minus ends of the spindles when compared to control cells.
Klp59C is required to depolymerise kinetochore-associated plus ends, thereby contributing to chromatid motility through a 'pac-man'-based mechanism.
The introduction of Klp59C inhibitors into embryos has no apparent effect on the organisation of mitotic spindles, but dies cause significant defects in chromomsome positioning and motility. Chromosomes and kinetochores fail to align tightly at the spindle equator during metaphase. Moreover normal chromosome segregation is prevented during anaphase.