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Gene Dmel\pita

General Information
Symbol	Dmel\pita	Species	D. melanogaster
Name	pita	Annotation symbol	CG3941
Feature type	protein_coding_gene	FlyBase ID	FBgn0034878
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	59E3-59E3	Sequence location	2R:19,436,488..19,442,241 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene pita is referred to in FlyBase by the symbol Dmel\pita (CG3941, FBgn0034878). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: regulation of gene silencing; DNA replication; DNA endoreduplication. 29 alleles are reported. The phenotypes of these alleles are annotated with: condensed nuclear chromosome; embryonic/larval salivary gland; mitotic anaphase; spindle; embryonic/larval tracheal system; imaginal disc; G2 phase of mitotic cell cycle; mitotic metaphase. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, AD-type; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding; Zinc finger, RING/FYVE/PHD-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1634094_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of pita. Gene sequence location is 2R:19436488..19442241.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA04006 BKN24203 HFA04435
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59E3-59E3   Limits computationally determined from genome sequence between P{lacW}l(2)s4830s4830&P{lacW}chrwk06908 and P{PZ}Dcp-102132
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\pita for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) pita-RA FBtr0072112  NM_137962   2480   683 pita-RB FBtr0072113  NM_166607   2435   623
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein pita-PA   FBpp0072021   78.3   683   7.30     NP_611806   AAF47026 pita-PB   FBpp0072022   71.6   623   7.31     NP_726339   AAF47025
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391126   AA391237   AA392155   AA392156   AA438671   AA440776   AA440919   AA540042   AA541012   AA694967   AA950983   AA951302   AE013599 AAF47025   AE013599 AAF47026   AI512574   AI513178   AI515923   AI518380   AI520074   AI520358   AI520443   AI530912   AI542823   AI543326   AI544128   AI546085   AI546518   AW942372   AY061206 AAL28754   BE662173   BE975352   BF485565   BI162785   BI164391   BI166365   BI231759   BI235382   BI238967   BI239655   BI243048   BI356563   BI356633   BI358648   BI372070   BI579517   BP545376   BP557639   CO178191   CO309265   CO333893   CO341642   CZ486155   EC051960   EC055558   EC056427   EC056579   EC060475   EC070616   EC081124   EC088293   EC090787   EC194376   EC198472   EC236405   EC260445   EV575288   G00735   GH821150   GH823369   GH823616   GH832525   GH835772   GH839512   GH875340   GH929632
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95RQ8 Q9W1N1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034878    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034878 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034878 expression level Developmental Stage   Expression Level embryo 00-02hr    5891 embryo 02-04hr    6182 embryo 04-06hr    5078 embryo 06-08hr    5208 embryo 08-10hr    4095 embryo 10-12hr    2388 embryo 12-14hr    1813 embryo 14-16hr    2292 embryo 16-18hr    1768 embryo 18-20hr    1254 embryo 20-22hr    3113 embryo 22-24hr    2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr    1639 white prepupae 24hr    1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day    1612 adult male 30day    1555 adult female 01day    1733 adult female 05day    2527 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5891) embryo 02-04hr  (6182) embryo 04-06hr  (5078) embryo 06-08hr  (5208) embryo 08-10hr  (4095) embryo 10-12hr  (2388) embryo 12-14hr  (1813) embryo 14-16hr  (2292) embryo 16-18hr  (1768) embryo 18-20hr  (1254) embryo 20-22hr  (3113) embryo 22-24hr  (2127) larva L1  (821) larva L2  (883) larva L3 12hr old  (763) larva L3 puffstage 1-2  (939) larva L3 puffstage 3-6  (1346) larva L3 puffstage 7-9  (1184) white prepupae new  (1058) white prepupae 12hr  (1639) white prepupae 24hr  (1674) pupae 2d postWPP  (1050) pupae 3d postWPP  (737) pupae 4d postWPP  (886) adult male 01day  (1062) adult male 05day  (1612) adult male 30day  (1555) adult female 01day  (1733) adult female 05day  (2527) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5891) embryo 02-04hr  (6182) embryo 04-06hr  (5078) embryo 06-08hr  (5208) embryo 08-10hr  (4095) embryo 10-12hr  (2388) embryo 12-14hr  (1813) embryo 14-16hr  (2292) embryo 16-18hr  (1768) embryo 18-20hr    1254 embryo 20-22hr  (3113) embryo 22-24hr  (2127) larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr  (1639) white prepupae 24hr  (1674) pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day  (1612) adult male 30day  (1555) adult female 01day  (1733) adult female 05day  (2527) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5891 embryo 02-04hr    6182 embryo 04-06hr    5078 embryo 06-08hr    5208 embryo 08-10hr    4095 embryo 10-12hr    2388 embryo 12-14hr    1813 embryo 14-16hr    2292 embryo 16-18hr    1768 embryo 18-20hr    1254 embryo 20-22hr    3113 embryo 22-24hr    2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr    1639 white prepupae 24hr    1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day    1612 adult male 30day    1555 adult female 01day    1733 adult female 05day    2527 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5891 embryo 02-04hr    6182 embryo 04-06hr    5078 embryo 06-08hr    5208 embryo 08-10hr    4095 embryo 10-12hr    2388 embryo 12-14hr    1813 embryo 14-16hr    2292 embryo 16-18hr    1768 embryo 18-20hr    1254 embryo 20-22hr    3113 embryo 22-24hr    2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr    1639 white prepupae 24hr    1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day    1612 adult male 30day    1555 adult female 01day    1733 adult female 05day    2527 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034878 expression level Developmental Stage   Expression Level embryo 00-02hr    5891 embryo 02-04hr    6182 embryo 04-06hr    5078 embryo 06-08hr    5208 embryo 08-10hr    4095 embryo 10-12hr    2388 embryo 12-14hr    1813 embryo 14-16hr    2292 embryo 16-18hr    1768 embryo 18-20hr    1254 embryo 20-22hr    3113 embryo 22-24hr    2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr    1639 white prepupae 24hr    1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day    1612 adult male 30day    1555 adult female 01day    1733 adult female 05day    2527 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5891) embryo 02-04hr  (6182) embryo 04-06hr  (5078) embryo 06-08hr  (5208) embryo 08-10hr  (4095) embryo 10-12hr  (2388) embryo 12-14hr  (1813) embryo 14-16hr  (2292) embryo 16-18hr  (1768) embryo 18-20hr  (1254) embryo 20-22hr  (3113) embryo 22-24hr  (2127) larva L1  (821) larva L2  (883) larva L3 12hr old  (763) larva L3 puffstage 1-2  (939) larva L3 puffstage 3-6  (1346) larva L3 puffstage 7-9  (1184) white prepupae new  (1058) white prepupae 12hr  (1639) white prepupae 24hr  (1674) pupae 2d postWPP  (1050) pupae 3d postWPP  (737) pupae 4d postWPP  (886) adult male 01day  (1062) adult male 05day  (1612) adult male 30day  (1555) adult female 01day  (1733) adult female 05day  (2527) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5891) embryo 02-04hr  (6182) embryo 04-06hr  (5078) embryo 06-08hr  (5208) embryo 08-10hr  (4095) embryo 10-12hr  2388 embryo 12-14hr  1813 embryo 14-16hr  2292 embryo 16-18hr  1768 embryo 18-20hr    1254 embryo 20-22hr  (3113) embryo 22-24hr  2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr  1639 white prepupae 24hr  1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day  1612 adult male 30day  1555 adult female 01day  1733 adult female 05day  (2527) adult female 30day  (2736) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5891 embryo 02-04hr    6182 embryo 04-06hr    5078 embryo 06-08hr    5208 embryo 08-10hr    4095 embryo 10-12hr    2388 embryo 12-14hr    1813 embryo 14-16hr    2292 embryo 16-18hr    1768 embryo 18-20hr    1254 embryo 20-22hr    3113 embryo 22-24hr    2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr    1639 white prepupae 24hr    1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day    1612 adult male 30day    1555 adult female 01day    1733 adult female 05day    2527 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5891 embryo 02-04hr    6182 embryo 04-06hr    5078 embryo 06-08hr    5208 embryo 08-10hr    4095 embryo 10-12hr    2388 embryo 12-14hr    1813 embryo 14-16hr    2292 embryo 16-18hr    1768 embryo 18-20hr    1254 embryo 20-22hr    3113 embryo 22-24hr    2127 larva L1    821 larva L2    883 larva L3 12hr old    763 larva L3 puffstage 1-2    939 larva L3 puffstage 3-6    1346 larva L3 puffstage 7-9    1184 white prepupae new    1058 white prepupae 12hr    1639 white prepupae 24hr    1674 pupae 2d postWPP    1050 pupae 3d postWPP    737 pupae 4d postWPP    886 adult male 01day    1062 adult male 05day    1612 adult male 30day    1555 adult female 01day    1733 adult female 05day    2527 adult female 30day    2736 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034878    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034878 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034878 expression level Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034878 expression level Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    282.8 Larval Midgut no informative data Larval Hindgut    74.4 Larval Malpighian Tubules    73.6 Larval Fat Body    75 Larval Salivary Gland    132.8 Larval Trachea    149.175 Larval Carcass    84.725 Adult Head    86.4 Adult Eye    106.925 Adult Brain    166.5 Adult Thoracic-Abdominal Ganglion    136.5 Adult Crop    114.7 Adult Midgut no informative data Adult Hindgut    92.2 Adult Malpighian Tubules    66.5 Adult Fat Body    53 Adult Salivary Gland    149.4 Adult Heart    64.125 Adult VirginFemale Spermatheca    67.9 Adult InseminatedFemale Spermatheca    73 Adult Ovary    364.4 Adult Testis    181.5 Adult Male Accessory Gland    121.6 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    86.4   NA  Eye    106.925   NA  Brain    166.5   282.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    136.5   NA  Crop    114.7   no informative data  Midgut    no informative data   74.4  Hindgut    92.2   73.6  Malpighian Tubules    66.5   75  Fat Body    53   132.8  Salivary Gland    149.4   NA  Heart    64.125   149.175  Trachea    NA   NA  VirginFemale Spermatheca    67.9   NA  InseminatedFemale Spermatheca    73   NA  Ovary    364.4   NA  Testis    181.5   NA  Male Accessory Gland    121.6   84.725  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034878 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3941-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for pita Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal pita02132 lethal | germline clone | maternal effect pita08859 lethal | larval stage pitak14408 lethal | larval stage | recessive pita1 pita3 lethal | prepupal stage | recessive pita2 lethal | pupal stage, with Scer\GAL4pnr-MD237 pitaGD11164 Sterility Allele female semi-sterile | germline clone pita2 Other Phenotypes Allele melanotic mass phenotype pitak14408 melanotic mass phenotype | larval stage | recessive pita1 pita3 mitotic cell cycle defective pita02121 pita08859 pitak14408 mitotic cell cycle defective (with Df(2R)bw5) pita02121 pita08859 pitak14408 Phenotype manifest in Allele condensed nuclear chromosome pita02121 pita08859 pitak14408 condensed nuclear chromosome (with Df(2R)bw5) pita02121 pita08859 pitak14408 egg chamber | germline clone pita08859 pita1 pita3 embryonic/larval salivary gland pita02121 pita08859 pitak14408 embryonic/larval tracheal system pita3 follicle cell | germline clone pita08859 pita3 G2 phase of mitotic cell cycle pita02121 pita08859 pitak14408 imaginal disc pita3 pitak14408 mitotic anaphase pita02121 pita08859 pitak14408 mitotic anaphase (with Df(2R)bw5) pita02121 pita08859 pitak14408 mitotic metaphase pita02121 pita08859 pitak14408 mitotic metaphase (with Df(2R)bw5) pita02121 pita08859 pitak14408 nurse cell & nucleus | germ-line clone pita08859 pita1 pita3 nurse cell & polytene chromosome | germ-line clone pita08859 pita1 nurse cell | germline clone pita08859 pita1 spindle pita02121 pita08859 pitak14408 spindle (with Df(2R)bw5) pita02121 pita08859 pitak14408
Classical Alleles ( 23 )
For All Classical Alleles Show
Allele of pita Class Mutagen Stocks Known lesion pitak05606 P-element activity 2 Yes pita02132 P-element activity 1 Yes pita5-HA-3057 1 -- pitaCB-6245-3 1 -- pitaCB-6506-3 1 -- pitaf03576 piggyBac transposase 1 -- pitaNP3296 1 -- pita01862 P-element activity 0 Yes pita02121 loss of function allele P-element activity 0 -- pita08859 loss of function allele P-element activity 0 Yes pita1 ethyl methanesulfonate 0 Yes pita2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes pita3 loss of function allele ethyl methanesulfonate 0 Yes pitaCB03160 P-element activity 0 Yes pitad00595 0 -- pitad11448 0 -- pitak14408 loss of function allele P-element activity 0 -- pitaLA4.1 P-element activity 0 -- pitalevy2 Delta2-3 0 Yes pitalevy3 Delta2-3 0 Yes pitalevy4 Delta2-3 0 Yes pitamgb48 P-element activity 0 Yes pitaSH0593 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of pita Class Mutagen Stocks Known lesion pitaGD11164 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pitaGLV21089 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes pitahs.PL in vitro construct - regulatory fusion 0 Yes pitaKK105067 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes pitaScer\UAS.cPb in vitro construct - regulatory fusion 0 Yes pitat2 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC785 (Christensen et al., 2009.5.6) Df(2R)Exel7180 (Ryder, 2004.4.26)
Partially disrupted in	Df(2R)levy2 (Liu et al., 2007) Df(2R)levy3 (Liu et al., 2007) Df(2R)levy4 (Liu et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11164} NA P{KK105067} NA P{TRiP.GLV21089} NA heat-shock construct P{hs-pita.L} NA characterization construct P{levy+t2} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Dcp-1k05606 No P{lacW}Dcp-1k14408 No P{lacW}l(2)SH0430SH0430 No P{lacW}pitaSH0593 No P{PZ}Dcp-101862 No P{PZ}Dcp-102121 No P{PZ}Dcp-102132 No P{PZ}Dcp-108859 No miscellaneous insertions P{hsp26-pt-T}Dcp-1mgb48 NA P{PTT-GB}Dcp-1CB03160 NA P{RS3}pitaCB-6245-3 NA P{RS3}pitaCB-6506-3 NA P{RS5}pita5-HA-3057 NA PBac{PB}Dcp-1c06469 NA PBac{RB}Dcp-1e04129 NA PBac{WH}pitaf03576 NA insertion of enhancer trap binary system P{GawB}pitaNP3296 No insertion of mobile activating element P{EP}pitaLA4.1 NA P{XP}Dcp-1d00593 NA P{XP}pitad00595 NA P{XP}pitad11448 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Page et al., 2005)
Biological Process
CV term Evidence References
DNA endoreduplication inferred from mutant phenotype (Page et al., 2005) DNA replication inferred from mutant phenotype (Page et al., 2005) regulation of gene silencing inferred from mutant phenotype (Schneiderman et al., 2010)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Page et al., 2005)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR012934, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mitosis non-traceable author statement (Ohkura et al., 1995)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions pita allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63330 DroID - A comprehensive database of gene and protein interactions. • FBgn0034878 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37730
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11837 Dere\GG20019 Dgri\GH20674 Dmoj\GI19037 Dper\GL17602 Dpse\GA17791 Dsec\GM15530 Dsim\GD15202 Dvir\GJ20004 Dwil\GK22925 Dyak\GE11555
Curated drosophilid orthologs	Dpse\GA17791
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003529-PA Aedes aegypti (mosquito) AGAP004764-PA Anopheles gambiae (mosquito) XP_001120957.1 Apis mellifera (honey bee) CPIJ010913 Culex pipens (mosquito) RP32784 Caenorhabditis remanei (nematode) XP_001607082.1 Nasonia vitripennis (wasp) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10393 LH18871 FBgn0229355 FBgn0224887 FBgn0207145 FBgn0186872 FBgn0170448 FBgn0077800 FBgn0155205 FBgn0141776 FBgn0128137 FBgn0112218 FBgn0088877 CPIJ010913 GB11357 AGAP008845 AAEL003529 PB26336 GLEAN_11051
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	11179 cn1 P{PZ}Dcp-102132 pita02132/CyO; ry506 35724 y1 sc* v1; P{TRiP.GLV21089}attP2/TM3, Sb1 10390 y1 w67c23; P{lacW}Dcp-1k05606 pitak05606/CyO
Harvard	- PBac{WH}pitaf03576
Kyoto	123997 w1118; P{RS3}pitaCB-6245-3 124129 w1118; P{RS3}pitaCB-6506-3 125788 w1118; P{RS5}pita5-HA-3057 108854 y1 w67c23; P{lacW}Dcp-1k05606/CyO 104444 y* w*; P{GawB}pitaNP3296 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v21739 w1118; P{GD11164}v21739
Genomic Clones ( 2 )
	BACR25I01 BACR48M01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 69 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15650
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT19603 GM01863 GM28793 LD10223 LD10615 LD11038 LD11039 LD12725 LD12992 LD19376 LD20770 LD31183 LD31695 LD37872 LD39355 LD40023 LD40492 LD40612 LD41630 LD44484 LD45378 LD46363 RE02016 RE04057 RE06470 RE23383 RE31222 RE35343 RE36207 RE40586 RE42741 RE42822 RE58086 RE73563 SD01683 SD02828 SD09291 SD10048
Other clones	10841 30209 83274 109228 214309.39 282305 bs27e04 bs41f09 CK01.2D.H6 CK01.70B.C9 CK01.102B.C5 Dmel_dig_008228_0688_3271 EC051960 EC055558 EC056427 EC056579 EK055911 EK217050 EK308257 EP12849 FGC030H12 FGM310D07 RP003228803 RP003260263 RP003270354 RP003331372 RP003389593 RP003449428 RP003469078 RP003523285
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034878 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37730
Antibody Information
Other Information
Discoverer
Etymology
	Named after a British pudding. The extremely overcondensed chromosomes in larval brain cells resemble the fruit in spotted dick. (Ohkura et al., 1995)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: pita spdk (Page et al., 2005)
Additional comments
Other Comments
	pita RNAi performed in cultured S2 cells results in an increase in the proportion of cells with DNA content intermediate to 2N and 4N 5 days after the initial treatment, characteristic of an increase in the proportion of cells in S phase. In contrast, the rate of cell proliferation is decreased to on average 1.2 times that of control cells. (Page et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137962 NM_166607 RefSeq (Proteins) • NP_611806 NP_726339 DDBJ / EMBL / GenBank • AA440776 AAF47025 AAF47026 AAL28754 AI520074 AW942372 AY061206 BE662173 CZ486155 G00735 Entrez Gene - A searchable database of RefSeq genes. • 37730 UniProtKB/TrEMBL • Q9W1N1 Q95RQ8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087) Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger, RING/FYVE/PHD-type (IPR013083)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63330 DroID - A comprehensive database of gene and protein interactions. • FBgn0034878 DRSC - Results from RNAi screens. • FBgn0034878 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034878 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3941-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034878 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37730 InParanoid A subset of ortholog calls from InParanoid. • AAEL003529-PA Aedes aegypti (mosquito) AGAP004764-PA Anopheles gambiae (mosquito) XP_001120957.1 Apis mellifera (honey bee) CPIJ010913 Culex pipens (mosquito) RP32784 Caenorhabditis remanei (nematode) XP_001607082.1 Nasonia vitripennis (wasp) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/pita-spotteddick.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37730 modMine - Data generated by the modENCODE project. • FBgn0034878 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10393 LH18871 FBgn0229355 FBgn0224887 FBgn0207145 FBgn0186872 FBgn0170448 FBgn0077800 FBgn0155205 FBgn0141776 FBgn0128137 FBgn0112218 FBgn0088877 CPIJ010913 GB11357 AGAP008845 AAEL003529 PB26336 GLEAN_11051
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG3941 (Lewis et al., 2004, Kearney et al., 2004, Brody et al., 2002, Dworkin and Gibson., 2006, Schneiderman et al., 2010, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) pita (Chung et al., 2007, Peterson et al., 2007, Buszczak et al., 2007, Liu et al., 2007, Kankel et al., 2007, Christensen et al., 2009.5.6, Schneiderman et al., 2010, Wasbrough et al., 2010) spdk (Ohkura et al., 1995, )
Name Synonym	pita   spotted dick (Ohkura et al., 1995)
Secondary FlyBase IDs
	FBgn0015545
References ( 38 )
Generate a list of	All references relating to this gene ( 38 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Schneiderman et al., 2010, PLoS Genet. 6(9): e1001095 Perturbation Analysis of Heterochromatin-Mediated Gene Silencing and Somatic Inheritance. [FBrf0211786] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...