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FB2021_04, released August 17, 2021

Gene: Dmel\ItgaPS5

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General Information
Symbol
Dmel\ItgaPS5
Species
D. melanogaster
Name
Integrin alphaPS5 subunit
Annotation Symbol
CG5372
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034880
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Summary
Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length. (UniProt, Q9W1M8)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

αPS5, alphaPS5, ItgαPS5, α-PS5

Key Links
Genomic Location
Cytogenetic map
59E4-59E4
Sequence location
2R:23,556,672..23,560,263 [+]
Recombination map
2-103
RefSeq locus
NT_033778 REGION:23556672..23560263
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein heterodimerization activity
inferred from sequence or structural similarity with FLYBASE:mys; FB:FBgn0004657
(FlyBase Curators, 2008--)
Biological Process (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in oocyte growth
inferred from mutant phenotype
(assigned by UniProt )
(Dinkins et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cell adhesion mediated by integrin
inferred from sequence or structural similarity with FLYBASE:mys; FB:FBgn0004657
(FlyBase Curators, 2008--)
involved_in cell-matrix adhesion
traceable author statement
(Hynes and Zhao, 2000)
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
traceable author statement
(Hynes and Zhao, 2000)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity with FLYBASE:mys; FB:FBgn0004657
(FlyBase Curators, 2008--)
part_of integrin complex
inferred from sequence or structural similarity
(Brown, 2000)
inferred from sequence or structural similarity with FLYBASE:mys; FB:FBgn0004657
(FlyBase Curators, 2008--)
non-traceable author statement
(Brower, 2003)
inferred from sequence or structural similarity with FLYBASE:scb; FB:FBgn0286785
(Hynes and Zhao, 2000)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the integrin alpha chain family. (Q9W1M8)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
INTEGRINS -
Integrins are heterodimeric transmembrane receptors composed of an α and β subunit that mediate cell-cell and cell-extracellular matrix adhesion. As well as maintaining tissue integrity, they are involved in morphogenesis and development. (Adapted from FBrf0167428).
Protein Function (UniProtKB)
Possible role in cell-cell interactions. Minor involvement in the establishment of the oocyte anterior-posterior length.
(UniProt, Q9W1M8)
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ItgaPS5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.52

Gene model reviewed during 6.23

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ItgaPS5-RB
FBtr0473618
NM_137964
3207
1018
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
ItgaPS5-PB
FBpp0423081
112.7
1018
6.29
AAF47029
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Heterodimer of an alpha and a beta subunit. Alpha-PS5 associates with beta-PS (By similarity).

(UniProt, Q9W1M8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ItgaPS5 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S11 -- S12
main body follicle cell
(Dinkins et al., 2008)
oogenesis stage S11 -- S13
dorsal appendage forming follicle cell
(Dinkins et al., 2008)
Additional Descriptive Data

ItgaPS5 is expressed in all follicle cells overlying the oocyte during oogenesis stages 11 and 12. The most intense staining develops at stage 12 in cells covering the anterior end of the oocyte and in cells that form the dorsal appendages.

(Dinkins et al., 2008)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\ItgaPS5 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ItgaPS5
Transgenic constructs containing regulatory region of ItgaPS5
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7180
(Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable (with Df(2R)BSC785)
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ITGA9
6 of 15
Yes
Yes
Hsap\ITGA4
5 of 15
No
Yes
Hsap\ITGA1
3 of 15
No
Yes
Hsap\ITGA2
3 of 15
No
Yes
Hsap\ITGA3
3 of 15
No
No
Hsap\ITGA6
3 of 15
No
No
Hsap\ITGA7
3 of 15
No
No
Hsap\ITGA10
3 of 15
No
Yes
Hsap\ITGA11
3 of 15
No
Yes
Hsap\ITGAD
3 of 15
No
Yes
Hsap\ITGAE
3 of 15
No
Yes
1  
Hsap\ITGAL
3 of 15
No
Yes
Hsap\ITGAM
3 of 15
No
Yes
Hsap\ITGAX
3 of 15
No
Yes
Hsap\ITGA2B
2 of 15
No
No
1  
Hsap\ITGA5
2 of 15
No
No
Hsap\ITGA8
2 of 15
No
No
2  
Hsap\ITGAV
2 of 15
No
No
Hsap\GPLD1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Itga4
5 of 15
Yes
No
Mmus\Itga9
5 of 15
Yes
Yes
Mmus\Itga1
3 of 15
No
Yes
Mmus\Itga2
3 of 15
No
Yes
Mmus\Itga3
3 of 15
No
No
Mmus\Itga6
3 of 15
No
No
Mmus\Itga7
3 of 15
No
No
Mmus\Itga11
3 of 15
No
Yes
Mmus\Itgad
3 of 15
No
Yes
Mmus\Itgae
3 of 15
No
Yes
Mmus\Itgal
3 of 15
No
Yes
Mmus\Itgam
3 of 15
No
Yes
Mmus\Itgax
3 of 15
No
Yes
Mmus\Itga2b
2 of 15
No
No
Mmus\Itga5
2 of 15
No
No
Mmus\Itga8
2 of 15
No
No
Mmus\Itga10
2 of 15
No
No
Mmus\Itgav
2 of 15
No
No
Mmus\Gpld1
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Itga4
4 of 13
Yes
Yes
Rnor\Itga9
4 of 13
Yes
Yes
Rnor\Itga3
3 of 13
No
No
Rnor\Itga7
3 of 13
No
No
Rnor\Itga10
3 of 13
No
Yes
Rnor\Itga11
3 of 13
No
Yes
Rnor\Itgax
3 of 13
No
Yes
Rnor\Itga1
2 of 13
No
Yes
Rnor\Itga2b
2 of 13
No
No
Rnor\Itga6
2 of 13
No
No
Rnor\Itga8
2 of 13
No
No
Rnor\Itgad
2 of 13
No
Yes
Rnor\Itgae
2 of 13
No
No
Rnor\Itgal
2 of 13
No
No
Rnor\Itgam
2 of 13
No
Yes
Rnor\Gpld1
1 of 13
No
Yes
Rnor\Itga2
1 of 13
No
No
Rnor\Itga5
1 of 13
No
No
Rnor\Itgav
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\itga4
5 of 12
Yes
Yes
Xtro\itga9
5 of 12
Yes
Yes
Xtro\itga2
3 of 12
No
Yes
Xtro\itga6
3 of 12
No
No
Xtro\itga11
3 of 12
No
Yes
Xtro\itga1
2 of 12
No
No
Xtro\itga2b.1
2 of 12
No
No
Xtro\itga5
2 of 12
No
No
Xtro\itga8
2 of 12
No
No
Xtro\itgav
2 of 12
No
No
Xtro\itga3
1 of 12
No
Yes
Danio rerio (Zebrafish) (22)
Drer\itga4
5 of 15
Yes
Yes
Drer\itga9
4 of 15
No
Yes
Drer\itga1
3 of 15
No
Yes
Drer\itga3a
3 of 15
No
No
Drer\itga3b
3 of 15
No
No
Drer\itga6a
3 of 15
No
No
Drer\itga6b
3 of 15
No
No
Drer\itga6l
3 of 15
No
No
Drer\itga10
3 of 15
No
Yes
Drer\itga11a
3 of 15
No
Yes
Drer\itga11b
3 of 15
No
Yes
Drer\itga2.2
2 of 15
No
No
Drer\itga2b
2 of 15
No
No
Drer\itga5
2 of 15
No
No
Drer\itgae.1
2 of 15
No
No
Drer\itgav
2 of 15
No
No
Drer\LOC100333484
2 of 15
No
Yes
Drer\si:dkey-32n7.4
2 of 15
No
Yes
Drer\zmp:0000001082
2 of 15
No
No
Drer\itga7
1 of 15
No
No
Drer\itga8
1 of 15
No
No
Drer\itgae.2
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\ina-1
2 of 15
Yes
No
Cele\pat-2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901O2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD11776
Drosophila sechellia
Dsec\GM16026
Drosophila yakuba
Dyak\GE14304
Drosophila yakuba
Dyak\GE28068
Drosophila yakuba
Dyak\GE14303
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150110 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004559
Musca domestica
House fly
Mdoa\17004560
Glossina morsitans
Tsetse fly
Gmor\GMOY001582
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10562
Mayetiola destructor
Hessian fly
Mdes\Mdes008603
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013381
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011038
Anopheles gambiae
Malaria mosquito
Agam\AGAP006826
Anopheles gambiae
Malaria mosquito
Agam\AGAP004303
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014514
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0776 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR006224
Strigamia maritima
European centipede
Smar\SMAR014703
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ItgaPS4
4 of 10
if
3 of 10
mew
3 of 10
scb
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ITGA9; integrin subunit alpha 9
    6 of 15
    603963
        ITGA4; integrin subunit alpha 4
        5 of 15
        192975
            ITGA1; integrin subunit alpha 1
            3 of 15
            192968
                ITGA2; integrin subunit alpha 2
                3 of 15
                192974
                    ITGA3; integrin subunit alpha 3
                    3 of 15
                    605025
                      ITGA6; integrin subunit alpha 6
                      3 of 15
                      147556
                      ITGA7; integrin subunit alpha 7
                      3 of 15
                      600536
                      ITGA10; integrin subunit alpha 10
                      3 of 15
                      604042
                          ITGA11; integrin subunit alpha 11
                          3 of 15
                          604789
                              ITGAD; integrin subunit alpha D
                              3 of 15
                              602453
                                  ITGAE; integrin subunit alpha E
                                  3 of 15
                                  604682
                                       
                                      ITGAL; integrin subunit alpha L
                                      3 of 15
                                      153370
                                          ITGAM; integrin subunit alpha M
                                          3 of 15
                                          120980
                                              ITGAX; integrin subunit alpha X
                                              3 of 15
                                              151510
                                                  Functional Complementation Data
                                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                  Interactions
                                                  Summary of Physical Interactions
                                                  esyN Network Diagram
                                                  Interactions Browser
                                                  Summary of Genetic Interactions
                                                  esyN Network Diagram
                                                  Starting gene(s)
                                                  Interaction type
                                                  Interacting gene(s)
                                                  Reference
                                                  Starting gene(s)
                                                  Interaction type
                                                  Interacting gene(s)
                                                  Reference
                                                  External Data
                                                  Subunit Structure (UniProtKB)
                                                  Heterodimer of an alpha and a beta subunit. Alpha-PS5 associates with beta-PS (By similarity).
                                                  (UniProt, Q9W1M8 )
                                                  Linkouts
                                                  BioGRID - A database of protein and genetic interactions.
                                                  DroID - A comprehensive database of gene and protein interactions.
                                                  Pathways
                                                  Signaling Pathways (FlyBase)
                                                  Metabolic Pathways
                                                  External Data
                                                  Linkouts
                                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                  Genomic Location and Detailed Mapping Data
                                                  Chromosome (arm)
                                                  2R
                                                  Recombination map
                                                  2-103
                                                  Cytogenetic map
                                                  59E4-59E4
                                                  Sequence location
                                                  2R:23,556,672..23,560,263 [+]
                                                  FlyBase Computed Cytological Location
                                                  Cytogenetic map
                                                  Evidence for location
                                                  59E4-59E4
                                                  Limits computationally determined from genome sequence between P{PZ}Dcp-102132 and P{EP}aptEP2339&P{PZ}apt06369
                                                  Experimentally Determined Cytological Location
                                                  Cytogenetic map
                                                  Notes
                                                  References
                                                  Experimentally Determined Recombination Data
                                                  Location

                                                  2-103

                                                  (FlyBase, 2016)

                                                  2-108.4

                                                  (Comeron et al., 2012)
                                                  Left of (cM)
                                                  Right of (cM)
                                                  Notes
                                                  Stocks and Reagents
                                                  Stocks (4)
                                                  Genomic Clones (14)
                                                   

                                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                  cDNA Clones (1)
                                                   

                                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                  cDNA clones, fully sequenced
                                                  BDGP DGC clones
                                                    Other clones
                                                      Drosophila Genomics Resource Center cDNA clones

                                                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                      cDNA Clones, End Sequenced (ESTs)
                                                      BDGP DGC clones
                                                        Other clones
                                                          RNAi and Array Information
                                                          Linkouts
                                                          DRSC - Results frm RNAi screens
                                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                          Antibody Information
                                                          Laboratory Generated Antibodies
                                                           
                                                          Commercially Available Antibodies
                                                           
                                                          Other Information
                                                          Relationship to Other Genes
                                                          Source for database identify of

                                                          Source for identity of: αPS5 CG5372

                                                          (Hynes and Zhao, 2000)

                                                          Source for identity of: ItgaPS5 αPS5

                                                          (Brown et al., 2013.2.5)
                                                          Source for database merge of
                                                          Additional comments
                                                          Other Comments
                                                          Origin and Etymology
                                                          Discoverer
                                                          Etymology
                                                          Identification
                                                          External Crossreferences and Linkouts ( 29 )
                                                          Sequence Crossreferences
                                                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                          Other crossreferences
                                                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                          DRscDB
                                                          EMBL-EBI Single Cell Expression Atlas
                                                          Flygut - An atlas of the Drosophila adult midgut
                                                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                                          InterPro - A database of protein families, domains and functional sites
                                                          KEGG Genes - Molecular building blocks of life in the genomic space.
                                                          MARRVEL_MODEL
                                                          modMine - A data warehouse for the modENCODE project
                                                          Linkouts
                                                          BioGRID - A database of protein and genetic interactions.
                                                          DroID - A comprehensive database of gene and protein interactions.
                                                          DRSC - Results frm RNAi screens
                                                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                          FlyMine - An integrated database for Drosophila genomics
                                                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                          Synonyms and Secondary IDs (11)
                                                          Datasets (0)
                                                          Study focus (0)
                                                          Experimental Role
                                                          Project
                                                          Project Type
                                                          Title
                                                          References (59)