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Gene Dmel\Sesn

General Information
Symbol	Dmel\Sesn	Species	D. melanogaster
Name	Sestrin	Annotation symbol	CG11299
Feature type	protein_coding_gene	FlyBase ID	FBgn0034897
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	59F6-59F7	Sequence location	2R:19,601,425..19,620,706 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sestrin is referred to in FlyBase by the symbol Dmel\Sesn (CG11299, FBgn0034897). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: inter-male aggressive behavior; regulation of reactive oxygen species metabolic process; mitochondrion degradation; multicellular organismal aging; negative regulation of cell growth. 12 alleles are reported. The phenotypes of these alleles are annotated with: Z disc; myofibril; actomyosin; wing blade; sarcomere; mitochondrion; M band. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: PA26 p53-induced protein (sestrin). Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635678_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG11299. Gene sequence location is 2R:19601425..19620706.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA04103 HFA04101 BKN27937 HFA04102 BKN45824
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59F6-59F7   Limits computationally determined from genome sequence between P{PZ}apt03041 and P{EP}eglEP938
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sesn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sesn-RA FBtr0072087  NM_137977   3095   497 Sesn-RB FBtr0113113  NM_001103967   3051   497 Sesn-RC FBtr0113114  NM_001103968   3080   497
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sesn-PA   FBpp0071996   55.9   497   5.10     NP_611821   AAF47053 Sesn-PB   FBpp0112026   55.9   497   5.10     NP_001097437   ABV53897 Sesn-PC   FBpp0112027   55.9   497   5.10     NP_001097438   ABV53898
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PA26 p53-induced protein (sestrin) (IPR006730)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202986   AA540832   AA803174   AA821227   AE013599 AAF47053   AE013599 ABV53897   AE013599 ABV53898   AI260760   AI294159   AI294974   AI295273   AI296206   AI297270   AI389035   AI403432   AI518927   AI519808   AI541737   AI945883   AW943476   AY069626 AAL39771   AY118804 AAM50664   BG637777   BG638880   BG638886   BI163952   BI173056   BI173767   BI216520   BI232808   BI242415   BI356757   BI358504   BI365581   BI367221   BI371658   BI374072   BI482143   BI482287   BI482385   BI484066   BI484367   BI484768   BI484789   BI485001   BI486646   BI578208   BI578648   BI618037   BI621175   BP552472   CA803202   CA803454   CK133820   CK657251   CK661839   CK662516   CO195341   CO196132   CO263703   CO264666   CO268368   CO270112   CO270279   CO272203   CO298446   CO305676   CO309435   CO311501   CO311515   CO316001   CO319702   CO321995   CO341903   CO343412   EC056710   EC059512   EC064915   EC065983   EC071280   EC078008   EC080384   EC197080   EC198532   EC213252   EC215873   EC223820   EC225334   EC226823   EC231587   EC242800   EC243706   EC246330   EC250380   EC251495   EC254942   EV600243   GH943471   GH949191   GH954659   GH966832   GH969826
UniProtKB/Swiss-Prot	Q9W1K5
UniProtKB/TrEMBL	Q8MSH7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034897    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034897 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034897 expression level Developmental Stage   Expression Level embryo 00-02hr    3789 embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr    2510 embryo 08-10hr    2653 embryo 10-12hr    3285 embryo 12-14hr    4811 embryo 14-16hr    5291 embryo 16-18hr    4386 embryo 18-20hr    3614 embryo 20-22hr    2078 embryo 22-24hr    2616 larva L1    1589 larva L2    1956 larva L3 12hr old    1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6    2827 larva L3 puffstage 7-9    5782 white prepupae new    10107 white prepupae 12hr    18478 white prepupae 24hr    13867 pupae 2d postWPP    15607 pupae 3d postWPP    6978 pupae 4d postWPP    5288 adult male 01day    4317 adult male 05day    2283 adult male 30day    2342 adult female 01day    4571 adult female 05day    2906 adult female 30day    3075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3789) embryo 02-04hr  (693) embryo 04-06hr  (732) embryo 06-08hr  (2510) embryo 08-10hr  (2653) embryo 10-12hr  (3285) embryo 12-14hr  (4811) embryo 14-16hr  (5291) embryo 16-18hr  (4386) embryo 18-20hr  (3614) embryo 20-22hr  (2078) embryo 22-24hr  (2616) larva L1  (1589) larva L2  (1956) larva L3 12hr old  (1700) larva L3 puffstage 1-2  (1305) larva L3 puffstage 3-6  (2827) larva L3 puffstage 7-9  (5782) white prepupae new  (10107) white prepupae 12hr  (18478) white prepupae 24hr  (13867) pupae 2d postWPP  (15607) pupae 3d postWPP  (6978) pupae 4d postWPP  (5288) adult male 01day  (4317) adult male 05day  (2283) adult male 30day  (2342) adult female 01day  (4571) adult female 05day  (2906) adult female 30day  (3075) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3789) embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr  (2510) embryo 08-10hr  (2653) embryo 10-12hr  (3285) embryo 12-14hr  (4811) embryo 14-16hr  (5291) embryo 16-18hr  (4386) embryo 18-20hr  (3614) embryo 20-22hr  (2078) embryo 22-24hr  (2616) larva L1  (1589) larva L2  (1956) larva L3 12hr old  (1700) larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6  (2827) larva L3 puffstage 7-9  (5782) white prepupae new  (10107) white prepupae 12hr  (18478) white prepupae 24hr  (13867) pupae 2d postWPP  (15607) pupae 3d postWPP  (6978) pupae 4d postWPP  (5288) adult male 01day  (4317) adult male 05day  (2283) adult male 30day  (2342) adult female 01day  (4571) adult female 05day  (2906) adult female 30day  (3075) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3789 embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr    2510 embryo 08-10hr    2653 embryo 10-12hr    3285 embryo 12-14hr    4811 embryo 14-16hr    5291 embryo 16-18hr    4386 embryo 18-20hr    3614 embryo 20-22hr    2078 embryo 22-24hr    2616 larva L1    1589 larva L2    1956 larva L3 12hr old    1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6    2827 larva L3 puffstage 7-9    5782 white prepupae new  10107 white prepupae 12hr  (18478) white prepupae 24hr  (13867) pupae 2d postWPP  (15607) pupae 3d postWPP    6978 pupae 4d postWPP    5288 adult male 01day    4317 adult male 05day    2283 adult male 30day    2342 adult female 01day    4571 adult female 05day    2906 adult female 30day    3075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3789 embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr    2510 embryo 08-10hr    2653 embryo 10-12hr    3285 embryo 12-14hr    4811 embryo 14-16hr    5291 embryo 16-18hr    4386 embryo 18-20hr    3614 embryo 20-22hr    2078 embryo 22-24hr    2616 larva L1    1589 larva L2    1956 larva L3 12hr old    1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6    2827 larva L3 puffstage 7-9    5782 white prepupae new    10107 white prepupae 12hr    18478 white prepupae 24hr    13867 pupae 2d postWPP    15607 pupae 3d postWPP    6978 pupae 4d postWPP    5288 adult male 01day    4317 adult male 05day    2283 adult male 30day    2342 adult female 01day    4571 adult female 05day    2906 adult female 30day    3075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034897 expression level Developmental Stage   Expression Level embryo 00-02hr    3789 embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr    2510 embryo 08-10hr    2653 embryo 10-12hr    3285 embryo 12-14hr    4811 embryo 14-16hr    5291 embryo 16-18hr    4386 embryo 18-20hr    3614 embryo 20-22hr    2078 embryo 22-24hr    2616 larva L1    1589 larva L2    1956 larva L3 12hr old    1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6    2827 larva L3 puffstage 7-9    5782 white prepupae new    10107 white prepupae 12hr    18478 white prepupae 24hr    13867 pupae 2d postWPP    15607 pupae 3d postWPP    6978 pupae 4d postWPP    5288 adult male 01day    4317 adult male 05day    2283 adult male 30day    2342 adult female 01day    4571 adult female 05day    2906 adult female 30day    3075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3789) embryo 02-04hr  (693) embryo 04-06hr  (732) embryo 06-08hr  (2510) embryo 08-10hr  (2653) embryo 10-12hr  (3285) embryo 12-14hr  (4811) embryo 14-16hr  (5291) embryo 16-18hr  (4386) embryo 18-20hr  (3614) embryo 20-22hr  (2078) embryo 22-24hr  (2616) larva L1  (1589) larva L2  (1956) larva L3 12hr old  (1700) larva L3 puffstage 1-2  (1305) larva L3 puffstage 3-6  (2827) larva L3 puffstage 7-9  (5782) white prepupae new  (10107) white prepupae 12hr  (18478) white prepupae 24hr  (13867) pupae 2d postWPP  (15607) pupae 3d postWPP  (6978) pupae 4d postWPP  (5288) adult male 01day  (4317) adult male 05day  (2283) adult male 30day  (2342) adult female 01day  (4571) adult female 05day  (2906) adult female 30day  (3075) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3789) embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr  (2510) embryo 08-10hr  (2653) embryo 10-12hr  (3285) embryo 12-14hr  (4811) embryo 14-16hr  (5291) embryo 16-18hr  (4386) embryo 18-20hr  (3614) embryo 20-22hr  2078 embryo 22-24hr  (2616) larva L1  1589 larva L2  1956 larva L3 12hr old  1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6  (2827) larva L3 puffstage 7-9  (5782) white prepupae new  (10107) white prepupae 12hr  (18478) white prepupae 24hr  (13867) pupae 2d postWPP  (15607) pupae 3d postWPP  (6978) pupae 4d postWPP  (5288) adult male 01day  (4317) adult male 05day  2283 adult male 30day  2342 adult female 01day  (4571) adult female 05day  (2906) adult female 30day  (3075) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3789 embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr    2510 embryo 08-10hr    2653 embryo 10-12hr    3285 embryo 12-14hr    4811 embryo 14-16hr    5291 embryo 16-18hr    4386 embryo 18-20hr    3614 embryo 20-22hr    2078 embryo 22-24hr    2616 larva L1    1589 larva L2    1956 larva L3 12hr old    1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6    2827 larva L3 puffstage 7-9    5782 white prepupae new  10107 white prepupae 12hr  18478 white prepupae 24hr  13867 pupae 2d postWPP  15607 pupae 3d postWPP    6978 pupae 4d postWPP    5288 adult male 01day    4317 adult male 05day    2283 adult male 30day    2342 adult female 01day    4571 adult female 05day    2906 adult female 30day    3075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3789 embryo 02-04hr    693 embryo 04-06hr    732 embryo 06-08hr    2510 embryo 08-10hr    2653 embryo 10-12hr    3285 embryo 12-14hr    4811 embryo 14-16hr    5291 embryo 16-18hr    4386 embryo 18-20hr    3614 embryo 20-22hr    2078 embryo 22-24hr    2616 larva L1    1589 larva L2    1956 larva L3 12hr old    1700 larva L3 puffstage 1-2    1305 larva L3 puffstage 3-6    2827 larva L3 puffstage 7-9    5782 white prepupae new    10107 white prepupae 12hr    18478 white prepupae 24hr    13867 pupae 2d postWPP    15607 pupae 3d postWPP    6978 pupae 4d postWPP    5288 adult male 01day    4317 adult male 05day    2283 adult male 30day    2342 adult female 01day    4571 adult female 05day    2906 adult female 30day    3075 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034897    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034897 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult midgut, larval/adult hindgut, adult heart, larval/adult fat body, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034897 expression level Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules    595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop    518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules    671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules  (595.3) Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop  518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules  (671.8) Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules    595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop    518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules    671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules    595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop    518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules    671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034897 expression level Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules    595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop    518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules    671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules  595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop  518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules  671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules    595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop    518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules    671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    51.6 Larval Midgut    214.5 Larval Hindgut    483.6 Larval Malpighian Tubules    595.3 Larval Fat Body    249.8 Larval Salivary Gland    52.5 Larval Trachea    29.375 Larval Carcass    263.9 Adult Head    177.9 Adult Eye    347.2 Adult Brain    79.3 Adult Thoracic-Abdominal Ganglion    77.5 Adult Crop    518.3 Adult Midgut    115.6 Adult Hindgut    240.2 Adult Malpighian Tubules    671.8 Adult Fat Body    298.5 Adult Salivary Gland no informative data Adult Heart    330.5 Adult VirginFemale Spermatheca    293.7 Adult InseminatedFemale Spermatheca    198.3 Adult Ovary    294.1 Adult Testis    17.8 Adult Male Accessory Gland    37.4 Adult Carcass    317.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    177.9   NA  Eye    347.2   NA  Brain    79.3   51.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    77.5   NA  Crop    518.3   214.5  Midgut    115.6   483.6  Hindgut    240.2   595.3  Malpighian Tubules    671.8   249.8  Fat Body    298.5   52.5  Salivary Gland    no informative data   NA  Heart    330.5   29.375  Trachea    NA   NA  VirginFemale Spermatheca    293.7   NA  InseminatedFemale Spermatheca    198.3   NA  Ovary    294.1   NA  Testis    17.8   NA  Male Accessory Gland    37.4   263.9  Carcass    317.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034897 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11299-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 SesnGD7263 Other Phenotypes Allele aging defective (with Sesn3F6) Sesn8A11 aging defective (with Sesn8A11) Sesn3F6 behavior defective | recessive SesnBG01215 cell growth defective, with Scer\GAL4ap-md544 Sesnd04539 visible, with Scer\GAL4ap-md544 SesnC86S.Scer\UAS.T:Hsap\MYC Sesnd04539 Phenotype manifest in Allele actomyosin (with Sesn3F6) Sesn8A11 actomyosin (with Sesn8A11) Sesn3F6 M band (with Sesn3F6) Sesn8A11 M band (with Sesn8A11) Sesn3F6 mitochondrion (with Sesn3F6) Sesn8A11 mitochondrion (with Sesn8A11) Sesn3F6 myofibril Sesn8A11 sarcomere (with Sesn3F6) Sesn8A11 sarcomere (with Sesn8A11) Sesn3F6 wing blade, with Scer\GAL4ap-md544 SesnC86S.Scer\UAS.T:Hsap\MYC Sesnd04539 Z disc (with Sesn3F6) Sesn8A11 Z disc (with Sesn8A11) Sesn3F6
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Sesn Class Mutagen Stocks Known lesion SesnBG01215 1 -- Sesnd04539 1 -- SesnMB02362 1 -- SesnMB08308 1 -- SesnMI03130 1 -- Sesn3F6 0 -- Sesn5-HA-2191 0 -- Sesn8A11 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sesn Class Mutagen Stocks Known lesion SesnGD7263 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SesnKK107937 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes SesnC86S.Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes SesnScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Sesn.MYC.C86S} NA P{UAS-Sesn.MYC} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}SesnMI03130 NA P{GT1}SesnBG01215 NA P{RS5}Sesn5-HA-2191 NA insertion of mobile activating element P{XP}Sesnd04539 NA insertion of enhancer trap binary system Mi{ET1}SesnMB02362 No Mi{ET1}SesnMB08308 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
inter-male aggressive behavior inferred from mutant phenotype (Edwards et al., 2009) mitochondrion degradation inferred from mutant phenotype (Lee et al., 2010) multicellular organismal aging inferred from mutant phenotype (Lee et al., 2010) negative regulation of cell growth inferred from mutant phenotype (Lee et al., 2010) regulation of reactive oxygen species metabolic process inferred from mutant phenotype (Lee et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle arrest inferred from electronic annotation with InterPro:IPR006730 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR006730 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sesn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63351 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034897 DroID - A comprehensive database of gene and protein interactions. • FBgn0034897 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37755
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13078 Dere\GG22883 Dgri\GH21308 Dmoj\GI19742 Dper\GL16884 Dpse\GA10899 Dsec\GM16042 Dsim\GD11791 Dvir\GJ18015 Dwil\GK23074 Dyak\GE14320
Curated drosophilid orthologs	Dpse\GA10899
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002487-PA Aedes aegypti (mosquito) AGAP007169-PA Anopheles gambiae (mosquito) XP_394521.3 Apis mellifera (honey bee) XP_001943649.1 Acyrthosiphon pisum (pea aphid) 219671 Branchiostoma floridae (lancelet) XP_001893812.1 Brugia malayi (roundworm nematode) ENSBTAP00000005267 Bos taurus (bovine) CN26073 Caenorhabditis brenneri (small nematode) CN30375 Caenorhabditis brenneri (small nematode) CBP21365 Caenorhabditis briggsae (nematode) CE40291 Caenorhabditis elegans (worm) ENSCAFP00000030785 Canis familiaris (dog) Chro.20240 Cryptosporidium hominis (obligate parasite) ENSCINP00000015711 Ciona intestinalis (sea squirt) JA03335 Caenorhabditis japonica (nematode) cgd2_2230 Cryptosporidium parvum (protozoan parasite) CPIJ010665 Culex pipens (mosquito) ENSCPOP00000012427 Cavia porcellus (guinea pig) RP35863 Caenorhabditis remanei (nematode) ENSCSAVP00000018064 Ciona savignyi (sedentary tunicate) 227278 Capitella spl (polychaete worm) DDB0232929 Dictyostelium discoideum (amoeba) 200622 Daphnia pulex (daphnia) ENSDARP00000062992 Danio rerio (zebra fish) ENSECAP00000001864 Equus caballus (horse) ENSGACP00000011747 Gymnopilus aculeatus (mushroom) ENSGALP00000027757 Gallus gallus (chicken) 185938 Hypsipyla robusta (cedar shoot borer) ENSP00000306734 Homo sapiens (human) ISCW002773-PA Ixodes scapularis (deer tick) 155490 Lottia gigantea (owl limpet) 1017 Monocosta brevicollis (choanoflagellate) ENSMODP00000000187 Monodelphis domestica (gray opossum) ENSMMUP00000023971 Macaca mulatta (rhesus monkey) ENSMUSP00000034507 Mus musculus (house mouse) 188161 Nematostella vectensis (starlet anemone) ENSOANP00000023654 Ornithorynchus anatinus (platypus) ENSORLP00000016911 Oryzias latipes (japanese killifish) PHUM001468-PA Pediculus humanus (human body louse) ENSPPYP00000018920 Pongo pygmaeus (orangutan) 74882 Phytophthora ramorum (sudden oak death pathogen) 134570 Phytophthora sojae (root rot pathogen) ENSPTRP00000031562 Pan troglodytes (chimpanzee) ENSRNOP00000011008 Rattus norvegicus (norway rat) Smp_147400 Schistosoma mansoni (trematode parasite) 25289 Trichoplax adhaerens (metazoa) XP_975462.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015244 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002816 Takifugu rubripes (pufferfish Takifugu) 41.m00243 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000015407 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19091 NV50217 LH17452 ISCW002773 FBgn0231935 FBgn0225036 FBgn0205180 FBgn0183530 FBgn0170958 JGI_V11_200622 FBgn0070955 FBgn0154488 FBgn0142479 FBgn0128770 FBgn0115040 FBgn0090111 CPIJ010665 ACYPI009413 GB12961 AGAP007169 AAEL002487 PHUM285310 GLEAN_03553
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	12606 w1118; P{GT1}SesnBG01215 23803 w1118; Mi{ET1}SesnMB02362 36202 y1 w*; Mi{MIC}SesnMI03130 26105 w1118; Mi{ET1}SesnMB08308 CG18128MB08308
Harvard	- P{XP}Sesnd04539
VDRC	v104365 P{KK107937}VIE-260B v38481 w1118; P{GD7263}v38481/TM3
Genomic Clones ( 1 )
	BACR02E09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 93 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20113 LD39604
Other clones	DPiM_LD39604
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH22866 GM10344 LD20655 LD38613 LD38625 LP04728 LP07471 LP08472 LP08858 LP10044 LP11537 LP21587 LP22795 LP23391 RE03487 RE15790 RE16865 RE23677 RE29016 RE39141 RE39738 RE42960 RE45282 RE50941 RE52935 RE58586 RE61585 RE64796 RE64958 RE65071 RE67103 RE67456 RE67919 RE67943 RE68221 RE70101 RE72048 RE72544 RH48553 RH52478 SD06848
Other clones	7879 31192 60892 66641 83433 102831 102929 146615 160557 161871 175568 214219.59 214473.74 bs17h11 CK01.29C.E12 CK01.107A.G5 CK01.108D.E4 CK01.111D.F12 CK01.119C.F6 CK01.127B.E5 Dmel_neb_015204_0942_3245 EC40083 EK001042 EK089327 EK091155 EK097415 EK098150 EK106219 EK139835 EK173027 EK186952 EK217635 EK224730 EK224759 EK249229 EK263318 EK280061 EP13362 EP16733 ESG011a.E7.4_E08 ESG011a.E21_E08 FGM218H12 HL07908 LD03406 RP004110812 RP004189004 RP004249860 RP004436536 RP004475788
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034897 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37755
Antibody Information
	polyclonal (Lee et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: CG11299 Sesn (Lee et al., 2010)
Source for database merge of	Source for merge of: CG11299 BcDNA:GH20113 (FlyBase, 1996-)
Additional comments	Source for merge of CG11299 BcDNA:GH20113 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137977 NM_001103967 NM_001103968 RefSeq (Proteins) • NP_611821 NP_001097437 NP_001097438 DDBJ / EMBL / GenBank • AAF47053 AAL39771 AAM50664 ABV53897 ABV53898 AI389035 AI519808 AI945883 AW943476 AY069626 AY118804 Entrez Gene - A searchable database of RefSeq genes. • 37755 UniProtKB/Swiss-Prot • Q9W1K5 UniProtKB/TrEMBL • Q8MSH7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PA26 p53-induced protein (sestrin) (IPR006730)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63351 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034897 DroID - A comprehensive database of gene and protein interactions. • FBgn0034897 DRSC - Results from RNAi screens. • FBgn0034897 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034897 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11299-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034897 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37755 InParanoid A subset of ortholog calls from InParanoid. • AAEL002487-PA Aedes aegypti (mosquito) AGAP007169-PA Anopheles gambiae (mosquito) XP_394521.3 Apis mellifera (honey bee) XP_001943649.1 Acyrthosiphon pisum (pea aphid) 219671 Branchiostoma floridae (lancelet) XP_001893812.1 Brugia malayi (roundworm nematode) ENSBTAP00000005267 Bos taurus (bovine) CN26073 Caenorhabditis brenneri (small nematode) CN30375 Caenorhabditis brenneri (small nematode) CBP21365 Caenorhabditis briggsae (nematode) CE40291 Caenorhabditis elegans (worm) ENSCAFP00000030785 Canis familiaris (dog) Chro.20240 Cryptosporidium hominis (obligate parasite) ENSCINP00000015711 Ciona intestinalis (sea squirt) JA03335 Caenorhabditis japonica (nematode) cgd2_2230 Cryptosporidium parvum (protozoan parasite) CPIJ010665 Culex pipens (mosquito) ENSCPOP00000012427 Cavia porcellus (guinea pig) RP35863 Caenorhabditis remanei (nematode) ENSCSAVP00000018064 Ciona savignyi (sedentary tunicate) 227278 Capitella spl (polychaete worm) DDB0232929 Dictyostelium discoideum (amoeba) 200622 Daphnia pulex (daphnia) ENSDARP00000062992 Danio rerio (zebra fish) ENSECAP00000001864 Equus caballus (horse) ENSGACP00000011747 Gymnopilus aculeatus (mushroom) ENSGALP00000027757 Gallus gallus (chicken) 185938 Hypsipyla robusta (cedar shoot borer) ENSP00000306734 Homo sapiens (human) ISCW002773-PA Ixodes scapularis (deer tick) 155490 Lottia gigantea (owl limpet) 1017 Monocosta brevicollis (choanoflagellate) ENSMODP00000000187 Monodelphis domestica (gray opossum) ENSMMUP00000023971 Macaca mulatta (rhesus monkey) ENSMUSP00000034507 Mus musculus (house mouse) 188161 Nematostella vectensis (starlet anemone) ENSOANP00000023654 Ornithorynchus anatinus (platypus) ENSORLP00000016911 Oryzias latipes (japanese killifish) PHUM001468-PA Pediculus humanus (human body louse) ENSPPYP00000018920 Pongo pygmaeus (orangutan) 74882 Phytophthora ramorum (sudden oak death pathogen) 134570 Phytophthora sojae (root rot pathogen) ENSPTRP00000031562 Pan troglodytes (chimpanzee) ENSRNOP00000011008 Rattus norvegicus (norway rat) Smp_147400 Schistosoma mansoni (trematode parasite) 25289 Trichoplax adhaerens (metazoa) XP_975462.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015244 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002816 Takifugu rubripes (pufferfish Takifugu) 41.m00243 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000015407 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37755 modMine - Data generated by the modENCODE project. • FBgn0034897 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB19091 NV50217 LH17452 ISCW002773 FBgn0231935 FBgn0225036 FBgn0205180 FBgn0183530 FBgn0170958 JGI_V11_200622 FBgn0070955 FBgn0154488 FBgn0142479 FBgn0128770 FBgn0115040 FBgn0090111 CPIJ010665 ACYPI009413 GB12961 AGAP007169 AAEL002487 PHUM285310 GLEAN_03553
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	BcDNA:GH20113   BEST:GH20113   CG11299 (Rehwinkel et al., 2006, Keleman et al., 2009.8.5, Edwards et al., 2009) dSesn (Lee et al., 2010) Sesn
Name Synonym	sestrin (Lee et al., 2010) Sestrin
Secondary FlyBase IDs
	FBgn0045816 FBgn0063233
References ( 19 )
Research paper	Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Edwards et al., 2009, BMC Biol. 7: 29 Mutations in many genes affect aggressive behavior in Drosophila melanogaster. [FBrf0208496] Rehwinkel et al., 2006, Molec. Cell. Biol. 26(8): 2965--2975 Genome-wide analysis of mRNAs regulated by Drosha and Argonaute proteins in Drosophila melanogaster. [FBrf0191204]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Bellen, 2011.5.31, set938.xml set938.xml [FBrf0213719] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Bellen, 2008.11.7, set816.xml set816.xml [FBrf0206132] Bellen, 2007.5.7, batch741.xml batch741.xml [FBrf0199562] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 2000.10.1, UniProtKB: Q9W1K5 PUTATIVE SESTRIN. [FBrf0136263]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Kodira, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126678]