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Gene Dmel\CG5554

General Information
Symbol	Dmel\CG5554	Species	D. melanogaster
Name		Annotation symbol	CG5554
Feature type	protein_coding_gene	FlyBase ID	FBgn0034914
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A3-60A3	Sequence location	2R:19,732,415..19,734,547 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG5554 (FBgn0034914). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein disulfide isomerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: cell redox homeostasis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Thioredoxin domain; Thioredoxin, conserved site; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult male reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632482_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5554. Gene sequence location is 2R:19732415..19734547.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA04513 BKN28624
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A3-60A3   Limits computationally determined from genome sequence between P{EP}eglEP938 and P{lacW}eIF6k13214
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG5554 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG5554-RA FBtr0072126  NM_137994   1674   323
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG5554-PA   FBpp0072035   36.3   323   4.22     NP_611838   AAF47072
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Thioredoxin-like fold (IPR012336) Thioredoxin domain (IPR013766) Thioredoxin, conserved site (IPR017937)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201921   AA202953   AA203091   AA263248   AA263491   AA390311   AA440883   AA538835   AA540495   AA816731   AA941173   AA941478   AA949716   AA951042   AA979398   AA979399   AA979406   AE013599 AAF47072   AI109011   AI134594   AI238073   AI258744   AI295241   AI456277   AI456458   AI456645   AI512180   AI512921   AI515842   AI515911   AI516799   AI517841   AI518526   AI520304   AI532853   AI534433   AI543964   AY118750 AAM50610   BF486365   BF496341   BF498895   BG635487   BG637975   BG638619   BH840689   BI169931   BI170003   BI172371   BI172981   BI227922   BI230444   BI231590   BI231977   BI235441   BI238323   BI239597   BI239913   BI241167   BI243255   BI355280   BI361400   BI365611   BI373186   BI373833   BI374351   BI481706   BI481855   BI483226   BI483966   BI577623   BI580846   BI580866   BI580884   BI637616   BI638253   CA804680   CK131944   CK659060   CO153405   CO153778   CO157100   CO269269   CO273931   CO273938   CO286804   CO343644   EC058079   EC059661   EC060536   EC078316   EC205835   EC211620   EC260625   EC262223   EC267281   EV589095   GH748538   GH748707   GH748741   GH749770   GH750980   GH753222   GH760582   GH784036   GH784118   GH784915   GH796724   GH797224   GH800737   GH808501   GH816758   GH817996   GH819127   GH821781   GH827239   GH832764   GH832822   GH834875   GH835354   GH836777   GH837248   GH846981   GH852719   GH856897   GH858994   GH859122   GH863075   GH867365   GH869449   GH870951   GH872729   GH882205   GH884546   GH885901   GH886456   GH888165   GH889567   GH891028   GH898775   GH905683   GH913998   GH924503   GH928679   GH929390
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W1I7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034914    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034914 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034914 expression level Developmental Stage   Expression Level embryo 00-02hr    9058 embryo 02-04hr    14207 embryo 04-06hr    13571 embryo 06-08hr    13118 embryo 08-10hr    15123 embryo 10-12hr    18354 embryo 12-14hr    11456 embryo 14-16hr    9705 embryo 16-18hr    6391 embryo 18-20hr    4278 embryo 20-22hr    6408 embryo 22-24hr    5262 larva L1    4139 larva L2    5495 larva L3 12hr old    3822 larva L3 puffstage 1-2    6074 larva L3 puffstage 3-6    13453 larva L3 puffstage 7-9    23065 white prepupae new    29708 white prepupae 12hr    10574 white prepupae 24hr    16429 pupae 2d postWPP    12078 pupae 3d postWPP    6996 pupae 4d postWPP    4114 adult male 01day    5626 adult male 05day    7394 adult male 30day    7020 adult female 01day    4496 adult female 05day    5810 adult female 30day    6109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9058) embryo 02-04hr  (14207) embryo 04-06hr  (13571) embryo 06-08hr  (13118) embryo 08-10hr  (15123) embryo 10-12hr  (18354) embryo 12-14hr  (11456) embryo 14-16hr  (9705) embryo 16-18hr  (6391) embryo 18-20hr  (4278) embryo 20-22hr  (6408) embryo 22-24hr  (5262) larva L1  (4139) larva L2  (5495) larva L3 12hr old  (3822) larva L3 puffstage 1-2  (6074) larva L3 puffstage 3-6  (13453) larva L3 puffstage 7-9  (23065) white prepupae new  (29708) white prepupae 12hr  (10574) white prepupae 24hr  (16429) pupae 2d postWPP  (12078) pupae 3d postWPP  (6996) pupae 4d postWPP  (4114) adult male 01day  (5626) adult male 05day  (7394) adult male 30day  (7020) adult female 01day  (4496) adult female 05day  (5810) adult female 30day  (6109) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9058) embryo 02-04hr  (14207) embryo 04-06hr  (13571) embryo 06-08hr  (13118) embryo 08-10hr  (15123) embryo 10-12hr  (18354) embryo 12-14hr  (11456) embryo 14-16hr  (9705) embryo 16-18hr  (6391) embryo 18-20hr  (4278) embryo 20-22hr  (6408) embryo 22-24hr  (5262) larva L1  (4139) larva L2  (5495) larva L3 12hr old  (3822) larva L3 puffstage 1-2  (6074) larva L3 puffstage 3-6  (13453) larva L3 puffstage 7-9  (23065) white prepupae new  (29708) white prepupae 12hr  (10574) white prepupae 24hr  (16429) pupae 2d postWPP  (12078) pupae 3d postWPP  (6996) pupae 4d postWPP  (4114) adult male 01day  (5626) adult male 05day  (7394) adult male 30day  (7020) adult female 01day  (4496) adult female 05day  (5810) adult female 30day  (6109) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9058 embryo 02-04hr  (14207) embryo 04-06hr  (13571) embryo 06-08hr  (13118) embryo 08-10hr  (15123) embryo 10-12hr  (18354) embryo 12-14hr  (11456) embryo 14-16hr    9705 embryo 16-18hr    6391 embryo 18-20hr    4278 embryo 20-22hr    6408 embryo 22-24hr    5262 larva L1    4139 larva L2    5495 larva L3 12hr old    3822 larva L3 puffstage 1-2    6074 larva L3 puffstage 3-6  (13453) larva L3 puffstage 7-9  (23065) white prepupae new  (29708) white prepupae 12hr  10574 white prepupae 24hr  (16429) pupae 2d postWPP  (12078) pupae 3d postWPP    6996 pupae 4d postWPP    4114 adult male 01day    5626 adult male 05day    7394 adult male 30day    7020 adult female 01day    4496 adult female 05day    5810 adult female 30day    6109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9058 embryo 02-04hr    14207 embryo 04-06hr    13571 embryo 06-08hr    13118 embryo 08-10hr    15123 embryo 10-12hr    18354 embryo 12-14hr    11456 embryo 14-16hr    9705 embryo 16-18hr    6391 embryo 18-20hr    4278 embryo 20-22hr    6408 embryo 22-24hr    5262 larva L1    4139 larva L2    5495 larva L3 12hr old    3822 larva L3 puffstage 1-2    6074 larva L3 puffstage 3-6    13453 larva L3 puffstage 7-9    23065 white prepupae new    29708 white prepupae 12hr    10574 white prepupae 24hr    16429 pupae 2d postWPP    12078 pupae 3d postWPP    6996 pupae 4d postWPP    4114 adult male 01day    5626 adult male 05day    7394 adult male 30day    7020 adult female 01day    4496 adult female 05day    5810 adult female 30day    6109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034914 expression level Developmental Stage   Expression Level embryo 00-02hr    9058 embryo 02-04hr    14207 embryo 04-06hr    13571 embryo 06-08hr    13118 embryo 08-10hr    15123 embryo 10-12hr    18354 embryo 12-14hr    11456 embryo 14-16hr    9705 embryo 16-18hr    6391 embryo 18-20hr    4278 embryo 20-22hr    6408 embryo 22-24hr    5262 larva L1    4139 larva L2    5495 larva L3 12hr old    3822 larva L3 puffstage 1-2    6074 larva L3 puffstage 3-6    13453 larva L3 puffstage 7-9    23065 white prepupae new    29708 white prepupae 12hr    10574 white prepupae 24hr    16429 pupae 2d postWPP    12078 pupae 3d postWPP    6996 pupae 4d postWPP    4114 adult male 01day    5626 adult male 05day    7394 adult male 30day    7020 adult female 01day    4496 adult female 05day    5810 adult female 30day    6109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9058) embryo 02-04hr  (14207) embryo 04-06hr  (13571) embryo 06-08hr  (13118) embryo 08-10hr  (15123) embryo 10-12hr  (18354) embryo 12-14hr  (11456) embryo 14-16hr  (9705) embryo 16-18hr  (6391) embryo 18-20hr  (4278) embryo 20-22hr  (6408) embryo 22-24hr  (5262) larva L1  (4139) larva L2  (5495) larva L3 12hr old  (3822) larva L3 puffstage 1-2  (6074) larva L3 puffstage 3-6  (13453) larva L3 puffstage 7-9  (23065) white prepupae new  (29708) white prepupae 12hr  (10574) white prepupae 24hr  (16429) pupae 2d postWPP  (12078) pupae 3d postWPP  (6996) pupae 4d postWPP  (4114) adult male 01day  (5626) adult male 05day  (7394) adult male 30day  (7020) adult female 01day  (4496) adult female 05day  (5810) adult female 30day  (6109) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9058) embryo 02-04hr  (14207) embryo 04-06hr  (13571) embryo 06-08hr  (13118) embryo 08-10hr  (15123) embryo 10-12hr  (18354) embryo 12-14hr  (11456) embryo 14-16hr  (9705) embryo 16-18hr  (6391) embryo 18-20hr  (4278) embryo 20-22hr  (6408) embryo 22-24hr  (5262) larva L1  (4139) larva L2  (5495) larva L3 12hr old  (3822) larva L3 puffstage 1-2  (6074) larva L3 puffstage 3-6  (13453) larva L3 puffstage 7-9  (23065) white prepupae new  (29708) white prepupae 12hr  (10574) white prepupae 24hr  (16429) pupae 2d postWPP  (12078) pupae 3d postWPP  (6996) pupae 4d postWPP  (4114) adult male 01day  (5626) adult male 05day  (7394) adult male 30day  (7020) adult female 01day  (4496) adult female 05day  (5810) adult female 30day  (6109) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9058 embryo 02-04hr  14207 embryo 04-06hr  13571 embryo 06-08hr  13118 embryo 08-10hr  15123 embryo 10-12hr  18354 embryo 12-14hr  11456 embryo 14-16hr    9705 embryo 16-18hr    6391 embryo 18-20hr    4278 embryo 20-22hr    6408 embryo 22-24hr    5262 larva L1    4139 larva L2    5495 larva L3 12hr old    3822 larva L3 puffstage 1-2    6074 larva L3 puffstage 3-6  13453 larva L3 puffstage 7-9  (23065) white prepupae new  (29708) white prepupae 12hr  10574 white prepupae 24hr  16429 pupae 2d postWPP  12078 pupae 3d postWPP    6996 pupae 4d postWPP    4114 adult male 01day    5626 adult male 05day    7394 adult male 30day    7020 adult female 01day    4496 adult female 05day    5810 adult female 30day    6109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9058 embryo 02-04hr    14207 embryo 04-06hr    13571 embryo 06-08hr    13118 embryo 08-10hr    15123 embryo 10-12hr    18354 embryo 12-14hr    11456 embryo 14-16hr    9705 embryo 16-18hr    6391 embryo 18-20hr    4278 embryo 20-22hr    6408 embryo 22-24hr    5262 larva L1    4139 larva L2    5495 larva L3 12hr old    3822 larva L3 puffstage 1-2    6074 larva L3 puffstage 3-6    13453 larva L3 puffstage 7-9    23065 white prepupae new    29708 white prepupae 12hr    10574 white prepupae 24hr    16429 pupae 2d postWPP    12078 pupae 3d postWPP    6996 pupae 4d postWPP    4114 adult male 01day    5626 adult male 05day    7394 adult male 30day    7020 adult female 01day    4496 adult female 05day    5810 adult female 30day    6109 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034914    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034914 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval hindgut, larval Malpighian tubules, larval fat body, larval salivary gland, larval trachea, adult male reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, adult hindgut, adult Malpighian tubules, adult heart, adult fat body, adult salivary gland, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034914 expression level Tissue   Expression Level Larval Central Nervous System    655.75 Larval Midgut    367.9 Larval Hindgut    616.4 Larval Malpighian Tubules    561.8 Larval Fat Body    4589.5 Larval Salivary Gland    1864 Larval Trachea    909.125 Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis    695.3 Adult Male Accessory Gland    859.1 Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (655.75) Larval Midgut    367.9 Larval Hindgut  (616.4) Larval Malpighian Tubules  (561.8) Larval Fat Body  (4589.5) Larval Salivary Gland  (1864) Larval Trachea  (909.125) Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis  (695.3) Adult Male Accessory Gland  (859.1) Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    655.75 Larval Midgut    367.9 Larval Hindgut    616.4 Larval Malpighian Tubules    561.8 Larval Fat Body  (4589.5) Larval Salivary Gland  (1864) Larval Trachea    909.125 Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis    695.3 Adult Male Accessory Gland    859.1 Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    655.75 Larval Midgut    367.9 Larval Hindgut    616.4 Larval Malpighian Tubules    561.8 Larval Fat Body    4589.5 Larval Salivary Gland    1864 Larval Trachea    909.125 Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis    695.3 Adult Male Accessory Gland    859.1 Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034914 expression level Tissue   Expression Level Larval Central Nervous System    655.75 Larval Midgut    367.9 Larval Hindgut    616.4 Larval Malpighian Tubules    561.8 Larval Fat Body    4589.5 Larval Salivary Gland    1864 Larval Trachea    909.125 Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis    695.3 Adult Male Accessory Gland    859.1 Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  655.75 Larval Midgut    367.9 Larval Hindgut  616.4 Larval Malpighian Tubules  561.8 Larval Fat Body  (4589.5) Larval Salivary Gland  (1864) Larval Trachea  (909.125) Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis  695.3 Adult Male Accessory Gland  (859.1) Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    655.75 Larval Midgut    367.9 Larval Hindgut    616.4 Larval Malpighian Tubules    561.8 Larval Fat Body  (4589.5) Larval Salivary Gland  (1864) Larval Trachea    909.125 Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis    695.3 Adult Male Accessory Gland    859.1 Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    655.75 Larval Midgut    367.9 Larval Hindgut    616.4 Larval Malpighian Tubules    561.8 Larval Fat Body    4589.5 Larval Salivary Gland    1864 Larval Trachea    909.125 Larval Carcass    492.875 Adult Head    226.2 Adult Eye    234.95 Adult Brain    385.4 Adult Thoracic-Abdominal Ganglion    339.7 Adult Crop    272.4 Adult Midgut    289.4 Adult Hindgut    286.9 Adult Malpighian Tubules    466.3 Adult Fat Body    360.1 Adult Salivary Gland    341.7 Adult Heart    423.65 Adult VirginFemale Spermatheca    380.1 Adult InseminatedFemale Spermatheca    399.8 Adult Ovary    395 Adult Testis    695.3 Adult Male Accessory Gland    859.1 Adult Carcass    196.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    226.2   NA  Eye    234.95   NA  Brain    385.4   655.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    339.7   NA  Crop    272.4   367.9  Midgut    289.4   616.4  Hindgut    286.9   561.8  Malpighian Tubules    466.3   4589.5  Fat Body    360.1   1864  Salivary Gland    341.7   NA  Heart    423.65   909.125  Trachea    NA   NA  VirginFemale Spermatheca    380.1   NA  InseminatedFemale Spermatheca    399.8   NA  Ovary    395   NA  Testis    695.3   NA  Male Accessory Gland    859.1   492.875  Carcass    196.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034914 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5554-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG5554GD2188 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG5554 Class Mutagen Stocks Known lesion CG5554KG06523 P-element activity 1 -- CG5554NP3485 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG5554 Class Mutagen Stocks Known lesion CG5554GD2188 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2188} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CG5554KG06523 NA insertion of enhancer trap binary system P{GawB}CG5554NP3485 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
protein disulfide isomerase activity inferred from sequence or structural similarity with EMBL:U79278 (FlyBase, 1992-)
Biological Process
CV term Evidence References
cell redox homeostasis inferred from electronic annotation with InterPro:IPR013766, InterPro:IPR017937 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Clissold and Bicknell, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG5554 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034914 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37775
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12510 Dere\GG22892 Dgri\GH22879 Dmoj\GI21260 Dper\GL11037 Dpse\GA18965 Dsec\GM16051 Dsim\GD11801 Dvir\GJ20862 Dwil\GK15815 Dyak\GE14330
Curated drosophilid orthologs	Dpse\GA18965
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000574-PB Aedes aegypti (mosquito) AGAP001613-PA Anopheles gambiae (mosquito) XP_397478.2 Apis mellifera (honey bee) XP_001949493.1 Acyrthosiphon pisum (pea aphid) 125814 Branchiostoma floridae (lancelet) 275793 Branchiostoma floridae (lancelet) BGIBMGA008199-PA Bombyx mori (silk worm) ENSBTAP00000014908 Bos taurus (bovine) CN22563 Caenorhabditis brenneri (small nematode) CBP04517 Caenorhabditis briggsae (nematode) CE20819 Caenorhabditis elegans (worm) ENSCAFP00000021563 Canis familiaris (dog) Chro.50157 Cryptosporidium hominis (obligate parasite) JA15558 Caenorhabditis japonica (nematode) cgd5_2230 Cryptosporidium parvum (protozoan parasite) CPIJ007303 Culex pipens (mosquito) ENSCPOP00000000393 Cavia porcellus (guinea pig) RP25782 Caenorhabditis remanei (nematode) ENSCSAVP00000019151 Ciona savignyi (sedentary tunicate) 173899 Capitella spl (polychaete worm) DDB0231738 Dictyostelium discoideum (amoeba) 99108 Daphnia pulex (daphnia) ENSDARP00000004160 Danio rerio (zebra fish) ENSECAP00000002633 Equus caballus (horse) ENSGACP00000015881 Gymnopilus aculeatus (mushroom) ENSGALP00000014368 Gallus gallus (chicken) 91406 Hypsipyla robusta (cedar shoot borer) ENSP00000267434 Homo sapiens (human) ISCW009878-PA Ixodes scapularis (deer tick) 235240 Lottia gigantea (owl limpet) ENSMODP00000016514 Monodelphis domestica (gray opossum) ENSMMUP00000002540 Macaca mulatta (rhesus monkey) ENSMUSP00000045154 Mus musculus (house mouse) 100694 Nematostella vectensis (starlet anemone) XP_001605724.1 Nasonia vitripennis (wasp) ENSOANP00000022011 Ornithorynchus anatinus (platypus) ENSORLP00000011153 Oryzias latipes (japanese killifish) PHUM001484-PA Pediculus humanus (human body louse) PP13506 Pristionchus pacificus (nematode) ENSPPYP00000006603 Pongo pygmaeus (orangutan) 573932 Populus trichocarpa (black cottonwood) ENSPTRP00000010747 Pan troglodytes (chimpanzee) ENSRNOP00000032896 Rattus norvegicus (norway rat) Smp_065190.2 Schistosoma mansoni (trematode parasite) 64389 Trichoplax adhaerens (metazoa) ENSTNIP00000022530 Tetraodon nigroviridis (green spotted pufferfish) 24560 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018283 Takifugu rubripes (pufferfish Takifugu) 3706.m01505 Tetrahymena thermophila (ciliate protozoa) 89386.m00154 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000035964 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11963 LH11632 ISCW009878 FBgn0231945 FBgn0217818 FBgn0207998 FBgn0183540 FBgn0170967 JGI_V11_99108 FBgn0078964 FBgn0148647 FBgn0143990 FBgn0130336 FBgn0115049 FBgn0089547 CPIJ007303 BGIBMGA008199 ACYPI005325 GB15245 AGAP001613 AAEL000574 PB19720 PHUM112940 GLEAN_02424
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	14301 y1 w67c23; P{SUPor-P}CG5554KG06523
Kyoto	104521 y* w*; P{GawB}CG5554NP3485 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v20101 w1118; P{GD2188}v20101
Genomic Clones ( 1 )
	BACR05F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 141 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH07506
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT10115 AT13311 AT20643 GH12105 GH14060 GM30190 LD03030 LD03365 LD03591 LD04059 LD05112 LD06346 LD06781 LD10965 LD15962 LD18454 LD20202 LD25160 LD25642 LD29705 LD30891 LD31312 LD33946 LD33947 LD33959 LD36168 LD36483 LD36734 LD38066 LD40425 LD41525 LD41614 LD42870 LD42917 LD43936 LD45047 LD45669 LP02013 LP08818 LP13056 LP16514 RE11248 RE11337 RE14126 RE14829 RE15703 RE22471 RE25165 RE25313 RE31283 RE34739 RE36138 RE36535 RE38184 RE40837 RE45601 RE50972 RE60421 RE61330 RE61915 RE64305 RE64462 RE66087 RE66949 RE71333 RE75083 RE75119 RE75129 SD04487 SD07250 SD12910 SD19667 SD20495
Other clones	11817 58778 172505 214575.51 522370 533966 CK01.3A.B10 CK01.61B.E7 CK01.123C.D5 Dmel_neb_008362_0387_2116 EK063920 EK094015 EK112656 EK112705 EN01914 EN02809 EN09933 EP17649 ESG0114d.B21_B12 RP003024185 RP003032013 RP003032734 RP003069898 RP003071486 RP003083594 RP003095706 RP003099923 RP003101413 RP003130246 RP003130495 RP003166613 RP003171533 RP003183185 RP003192353 RP003211768 RP003215494 RP003233348 RP003246607 RP003256163 RP003266765 RP003305351 RP003319928 RP003351766 RP003356061 RP003365708 RP003368571 RP003369041 RP003392182 RP003404021 RP003412037 RP003430103 RP003437264 RP003442379 RP003453960 RP003454780 RP003472981 RP003481248 RP003482268 RP003504517 RP003509858 RP003532434 RP003559558 RP003582231 RP003584211 RP003592719 RP003631077 RP003634158
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034914 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37775
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_137994 RefSeq (Proteins) • NP_611838 DDBJ / EMBL / GenBank • AAF47072 AAM50610 AI109011 AY118750 BH840689 Entrez Gene - A searchable database of RefSeq genes. • 37775 UniProtKB/TrEMBL • Q9W1I7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Thioredoxin-like fold (IPR012336) Thioredoxin domain (IPR013766) Thioredoxin, conserved site (IPR017937)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034914 DRSC - Results from RNAi screens. • FBgn0034914 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034914 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5554-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034914 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37775 InParanoid A subset of ortholog calls from InParanoid. • AAEL000574-PB Aedes aegypti (mosquito) AGAP001613-PA Anopheles gambiae (mosquito) XP_397478.2 Apis mellifera (honey bee) XP_001949493.1 Acyrthosiphon pisum (pea aphid) 125814 Branchiostoma floridae (lancelet) 275793 Branchiostoma floridae (lancelet) BGIBMGA008199-PA Bombyx mori (silk worm) ENSBTAP00000014908 Bos taurus (bovine) CN22563 Caenorhabditis brenneri (small nematode) CBP04517 Caenorhabditis briggsae (nematode) CE20819 Caenorhabditis elegans (worm) ENSCAFP00000021563 Canis familiaris (dog) Chro.50157 Cryptosporidium hominis (obligate parasite) JA15558 Caenorhabditis japonica (nematode) cgd5_2230 Cryptosporidium parvum (protozoan parasite) CPIJ007303 Culex pipens (mosquito) ENSCPOP00000000393 Cavia porcellus (guinea pig) RP25782 Caenorhabditis remanei (nematode) ENSCSAVP00000019151 Ciona savignyi (sedentary tunicate) 173899 Capitella spl (polychaete worm) DDB0231738 Dictyostelium discoideum (amoeba) 99108 Daphnia pulex (daphnia) ENSDARP00000004160 Danio rerio (zebra fish) ENSECAP00000002633 Equus caballus (horse) ENSGACP00000015881 Gymnopilus aculeatus (mushroom) ENSGALP00000014368 Gallus gallus (chicken) 91406 Hypsipyla robusta (cedar shoot borer) ENSP00000267434 Homo sapiens (human) ISCW009878-PA Ixodes scapularis (deer tick) 235240 Lottia gigantea (owl limpet) ENSMODP00000016514 Monodelphis domestica (gray opossum) ENSMMUP00000002540 Macaca mulatta (rhesus monkey) ENSMUSP00000045154 Mus musculus (house mouse) 100694 Nematostella vectensis (starlet anemone) XP_001605724.1 Nasonia vitripennis (wasp) ENSOANP00000022011 Ornithorynchus anatinus (platypus) ENSORLP00000011153 Oryzias latipes (japanese killifish) PHUM001484-PA Pediculus humanus (human body louse) PP13506 Pristionchus pacificus (nematode) ENSPPYP00000006603 Pongo pygmaeus (orangutan) 573932 Populus trichocarpa (black cottonwood) ENSPTRP00000010747 Pan troglodytes (chimpanzee) ENSRNOP00000032896 Rattus norvegicus (norway rat) Smp_065190.2 Schistosoma mansoni (trematode parasite) 64389 Trichoplax adhaerens (metazoa) ENSTNIP00000022530 Tetraodon nigroviridis (green spotted pufferfish) 24560 Thalassiosira pseudonana (marine diatom) ENSTRUP00000018283 Takifugu rubripes (pufferfish Takifugu) 3706.m01505 Tetrahymena thermophila (ciliate protozoa) 89386.m00154 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000035964 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37775 modMine - Data generated by the modENCODE project. • FBgn0034914 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11963 LH11632 ISCW009878 FBgn0231945 FBgn0217818 FBgn0207998 FBgn0183540 FBgn0170967 JGI_V11_99108 FBgn0078964 FBgn0148647 FBgn0143990 FBgn0130336 FBgn0115049 FBgn0089547 CPIJ007303 BGIBMGA008199 ACYPI005325 GB15245 AGAP001613 AAEL000574 PB19720 PHUM112940 GLEAN_02424
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG5554 (Cammarato et al., 2011)
Name Synonym
Secondary FlyBase IDs
References ( 14 )
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Clissold and Bicknell, 2003, BioEssays 25(6): The thioredoxin-like fold: hidden domains in protein disulfide isomerase and other chaperone proteins. [FBrf0159917]
Review	Clissold and Bicknell, 2003, BioEssays 25(6): 603--611 The thioredoxin-like fold: hidden domains in protein disulfide isomerase and other chaperone proteins. [FBrf0159916]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Beasley, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126653]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]