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Gene Dmel\eIF6

General Information
Symbol	Dmel\eIF6	Species	D. melanogaster
Name	eIF6	Annotation symbol	CG17611
Feature type	protein_coding_gene	FlyBase ID	FBgn0034915
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	l(2)k13214
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A3-60A3	Sequence location	2R:19,736,769..19,737,822 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eIF6 is referred to in FlyBase by the symbol Dmel\eIF6 (CG17611, FBgn0034915). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: translational initiation. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Translation initiation factor IF6. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633284_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of eIF6. Gene sequence location is 2R:19736769..19737822.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA04674 BKN21310
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A3-60A3   Limits computationally determined from genome sequence between P{EP}eglEP938 and P{lacW}eIF6k13214
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60A2-60A3     (Kaiser, 1996.4.19) 60A3-60A4   (determined by in situ hybridisation)   (Spradling et al., 1999) 60A3-60A4     (Beaton, 1997.12.27) 60A3-60A4     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF6-RA FBtr0072235  NM_145105   1054   245
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF6-PA   FBpp0072144   26.5   245   4.34     NP_659573   AAF47074
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Translation initiation factor IF6 (IPR002769)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF47074   AI109537   AQ026049   AW941716   AX260191   AX260193   AY094688 AAM11041   BE979055   BF486927   BI142033   BI172738   BI231576   BI605824   BI633807   CO265692   CO305127   CO337806   EC244695   EC265243   EV585317   X97641
UniProtKB/Swiss-Prot	P56538
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034915    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034915 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034915 expression level Developmental Stage   Expression Level embryo 00-02hr    4937 embryo 02-04hr    1968 embryo 04-06hr    4636 embryo 06-08hr    6729 embryo 08-10hr    5117 embryo 10-12hr    4527 embryo 12-14hr    2297 embryo 14-16hr    2360 embryo 16-18hr    1878 embryo 18-20hr    1793 embryo 20-22hr    4352 embryo 22-24hr    3218 larva L1    10937 larva L2    5234 larva L3 12hr old    3448 larva L3 puffstage 1-2    2101 larva L3 puffstage 3-6    3127 larva L3 puffstage 7-9    2952 white prepupae new    2527 white prepupae 12hr    2958 white prepupae 24hr    3197 pupae 2d postWPP    2417 pupae 3d postWPP    1535 pupae 4d postWPP    2206 adult male 01day    2376 adult male 05day    3238 adult male 30day    3714 adult female 01day    5466 adult female 05day    5189 adult female 30day    6028 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4937) embryo 02-04hr  (1968) embryo 04-06hr  (4636) embryo 06-08hr  (6729) embryo 08-10hr  (5117) embryo 10-12hr  (4527) embryo 12-14hr  (2297) embryo 14-16hr  (2360) embryo 16-18hr  (1878) embryo 18-20hr  (1793) embryo 20-22hr  (4352) embryo 22-24hr  (3218) larva L1  (10937) larva L2  (5234) larva L3 12hr old  (3448) larva L3 puffstage 1-2  (2101) larva L3 puffstage 3-6  (3127) larva L3 puffstage 7-9  (2952) white prepupae new  (2527) white prepupae 12hr  (2958) white prepupae 24hr  (3197) pupae 2d postWPP  (2417) pupae 3d postWPP  (1535) pupae 4d postWPP  (2206) adult male 01day  (2376) adult male 05day  (3238) adult male 30day  (3714) adult female 01day  (5466) adult female 05day  (5189) adult female 30day  (6028) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4937) embryo 02-04hr  (1968) embryo 04-06hr  (4636) embryo 06-08hr  (6729) embryo 08-10hr  (5117) embryo 10-12hr  (4527) embryo 12-14hr  (2297) embryo 14-16hr  (2360) embryo 16-18hr  (1878) embryo 18-20hr  (1793) embryo 20-22hr  (4352) embryo 22-24hr  (3218) larva L1  (10937) larva L2  (5234) larva L3 12hr old  (3448) larva L3 puffstage 1-2  (2101) larva L3 puffstage 3-6  (3127) larva L3 puffstage 7-9  (2952) white prepupae new  (2527) white prepupae 12hr  (2958) white prepupae 24hr  (3197) pupae 2d postWPP  (2417) pupae 3d postWPP  (1535) pupae 4d postWPP  (2206) adult male 01day  (2376) adult male 05day  (3238) adult male 30day  (3714) adult female 01day  (5466) adult female 05day  (5189) adult female 30day  (6028) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4937 embryo 02-04hr    1968 embryo 04-06hr    4636 embryo 06-08hr    6729 embryo 08-10hr    5117 embryo 10-12hr    4527 embryo 12-14hr    2297 embryo 14-16hr    2360 embryo 16-18hr    1878 embryo 18-20hr    1793 embryo 20-22hr    4352 embryo 22-24hr    3218 larva L1  (10937) larva L2    5234 larva L3 12hr old    3448 larva L3 puffstage 1-2    2101 larva L3 puffstage 3-6    3127 larva L3 puffstage 7-9    2952 white prepupae new    2527 white prepupae 12hr    2958 white prepupae 24hr    3197 pupae 2d postWPP    2417 pupae 3d postWPP    1535 pupae 4d postWPP    2206 adult male 01day    2376 adult male 05day    3238 adult male 30day    3714 adult female 01day    5466 adult female 05day    5189 adult female 30day    6028 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4937 embryo 02-04hr    1968 embryo 04-06hr    4636 embryo 06-08hr    6729 embryo 08-10hr    5117 embryo 10-12hr    4527 embryo 12-14hr    2297 embryo 14-16hr    2360 embryo 16-18hr    1878 embryo 18-20hr    1793 embryo 20-22hr    4352 embryo 22-24hr    3218 larva L1    10937 larva L2    5234 larva L3 12hr old    3448 larva L3 puffstage 1-2    2101 larva L3 puffstage 3-6    3127 larva L3 puffstage 7-9    2952 white prepupae new    2527 white prepupae 12hr    2958 white prepupae 24hr    3197 pupae 2d postWPP    2417 pupae 3d postWPP    1535 pupae 4d postWPP    2206 adult male 01day    2376 adult male 05day    3238 adult male 30day    3714 adult female 01day    5466 adult female 05day    5189 adult female 30day    6028 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034915 expression level Developmental Stage   Expression Level embryo 00-02hr    4937 embryo 02-04hr    1968 embryo 04-06hr    4636 embryo 06-08hr    6729 embryo 08-10hr    5117 embryo 10-12hr    4527 embryo 12-14hr    2297 embryo 14-16hr    2360 embryo 16-18hr    1878 embryo 18-20hr    1793 embryo 20-22hr    4352 embryo 22-24hr    3218 larva L1    10937 larva L2    5234 larva L3 12hr old    3448 larva L3 puffstage 1-2    2101 larva L3 puffstage 3-6    3127 larva L3 puffstage 7-9    2952 white prepupae new    2527 white prepupae 12hr    2958 white prepupae 24hr    3197 pupae 2d postWPP    2417 pupae 3d postWPP    1535 pupae 4d postWPP    2206 adult male 01day    2376 adult male 05day    3238 adult male 30day    3714 adult female 01day    5466 adult female 05day    5189 adult female 30day    6028 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4937) embryo 02-04hr  (1968) embryo 04-06hr  (4636) embryo 06-08hr  (6729) embryo 08-10hr  (5117) embryo 10-12hr  (4527) embryo 12-14hr  (2297) embryo 14-16hr  (2360) embryo 16-18hr  (1878) embryo 18-20hr  (1793) embryo 20-22hr  (4352) embryo 22-24hr  (3218) larva L1  (10937) larva L2  (5234) larva L3 12hr old  (3448) larva L3 puffstage 1-2  (2101) larva L3 puffstage 3-6  (3127) larva L3 puffstage 7-9  (2952) white prepupae new  (2527) white prepupae 12hr  (2958) white prepupae 24hr  (3197) pupae 2d postWPP  (2417) pupae 3d postWPP  (1535) pupae 4d postWPP  (2206) adult male 01day  (2376) adult male 05day  (3238) adult male 30day  (3714) adult female 01day  (5466) adult female 05day  (5189) adult female 30day  (6028) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4937) embryo 02-04hr  1968 embryo 04-06hr  (4636) embryo 06-08hr  (6729) embryo 08-10hr  (5117) embryo 10-12hr  (4527) embryo 12-14hr  2297 embryo 14-16hr  2360 embryo 16-18hr  1878 embryo 18-20hr  1793 embryo 20-22hr  (4352) embryo 22-24hr  (3218) larva L1  (10937) larva L2  (5234) larva L3 12hr old  (3448) larva L3 puffstage 1-2  2101 larva L3 puffstage 3-6  (3127) larva L3 puffstage 7-9  (2952) white prepupae new  (2527) white prepupae 12hr  (2958) white prepupae 24hr  (3197) pupae 2d postWPP  2417 pupae 3d postWPP  1535 pupae 4d postWPP  2206 adult male 01day  2376 adult male 05day  (3238) adult male 30day  (3714) adult female 01day  (5466) adult female 05day  (5189) adult female 30day  (6028) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4937 embryo 02-04hr    1968 embryo 04-06hr    4636 embryo 06-08hr    6729 embryo 08-10hr    5117 embryo 10-12hr    4527 embryo 12-14hr    2297 embryo 14-16hr    2360 embryo 16-18hr    1878 embryo 18-20hr    1793 embryo 20-22hr    4352 embryo 22-24hr    3218 larva L1  10937 larva L2    5234 larva L3 12hr old    3448 larva L3 puffstage 1-2    2101 larva L3 puffstage 3-6    3127 larva L3 puffstage 7-9    2952 white prepupae new    2527 white prepupae 12hr    2958 white prepupae 24hr    3197 pupae 2d postWPP    2417 pupae 3d postWPP    1535 pupae 4d postWPP    2206 adult male 01day    2376 adult male 05day    3238 adult male 30day    3714 adult female 01day    5466 adult female 05day    5189 adult female 30day    6028 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4937 embryo 02-04hr    1968 embryo 04-06hr    4636 embryo 06-08hr    6729 embryo 08-10hr    5117 embryo 10-12hr    4527 embryo 12-14hr    2297 embryo 14-16hr    2360 embryo 16-18hr    1878 embryo 18-20hr    1793 embryo 20-22hr    4352 embryo 22-24hr    3218 larva L1    10937 larva L2    5234 larva L3 12hr old    3448 larva L3 puffstage 1-2    2101 larva L3 puffstage 3-6    3127 larva L3 puffstage 7-9    2952 white prepupae new    2527 white prepupae 12hr    2958 white prepupae 24hr    3197 pupae 2d postWPP    2417 pupae 3d postWPP    1535 pupae 4d postWPP    2206 adult male 01day    2376 adult male 05day    3238 adult male 30day    3714 adult female 01day    5466 adult female 05day    5189 adult female 30day    6028 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034915    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034915 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034915 expression level Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034915 expression level Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    353.45 Larval Midgut    148.2 Larval Hindgut    183.3 Larval Malpighian Tubules    113.6 Larval Fat Body    137.6 Larval Salivary Gland    264 Larval Trachea    321.375 Larval Carcass    270.55 Adult Head    123.9 Adult Eye    101.25 Adult Brain    87.3 Adult Thoracic-Abdominal Ganglion    114.3 Adult Crop    133.5 Adult Midgut    219.4 Adult Hindgut    125 Adult Malpighian Tubules    132.7 Adult Fat Body    151.7 Adult Salivary Gland    157 Adult Heart    121.15 Adult VirginFemale Spermatheca    94.2 Adult InseminatedFemale Spermatheca    121 Adult Ovary    342.1 Adult Testis    239.3 Adult Male Accessory Gland    248.4 Adult Carcass    145.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    123.9   NA  Eye    101.25   NA  Brain    87.3   353.45  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    114.3   NA  Crop    133.5   148.2  Midgut    219.4   183.3  Hindgut    125   113.6  Malpighian Tubules    132.7   137.6  Fat Body    151.7   264  Salivary Gland    157   NA  Heart    121.15   321.375  Trachea    NA   NA  VirginFemale Spermatheca    94.2   NA  InseminatedFemale Spermatheca    121   NA  Ovary    342.1   NA  Testis    239.3   NA  Male Accessory Gland    248.4   270.55  Carcass    145.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034915 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17611-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for eIF6 Stages(s) 1-3 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive eIF6k13214 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of eIF6 Class Mutagen Stocks Known lesion eIF6k13214 P-element activity 2 Yes eIF65E24 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF6 Class Mutagen Stocks Known lesion eIF6KK101259 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF6GD9425 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)BSC600 (Christensen et al., 2008.9.3) Df(2R)BSC610 (Christensen et al., 2008.9.3) Df(2R)BSC660 (Christensen et al., 2008.12.28) Df(2R)bwVDe2LPxKR (Spradling et al., 1999, Beaton, 1997.12.27) Df(2R)bw-S46 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9425} NA P{KK101259} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}eIF6k13214 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ribosome binding inferred from electronic annotation with InterPro:IPR002769 (FlyBase Curators et al., 2004-) translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with EMBL:AF022229 (Mi et al., 2001.12.13)
Biological Process
CV term Evidence References
mature ribosome assembly inferred from electronic annotation with InterPro:IPR002769 (FlyBase Curators et al., 2004-) translation non-traceable author statement (Swiss-Prot Project Members, 1998.2.1) translational initiation inferred from sequence or structural similarity (Lasko, 2000)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF6 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0034915 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37776
Orthologs
Genome-wide drosophilid orthologs	Dgri\GH24978 Dvir\GJ21479
Curated drosophilid orthologs	Dpse\GA14578
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003661-PA Aedes aegypti (mosquito) AGAP001380-PA Anopheles gambiae (mosquito) XP_392115.1 Apis mellifera (honey bee) XP_001946083.1 Acyrthosiphon pisum (pea aphid) At3g55620.1 Arabidopsis thaliana (wall cress) 30647 Batrachochytrium dendrobatidis (chytrid fungus) 127243 Branchiostoma floridae (lancelet) BGIBMGA009830-PA Bombyx mori (silk worm) ENSBTAP00000014966 Bos taurus (bovine) CAL0001603 Candida albicans (a form of yeast) CN14352 Caenorhabditis brenneri (small nematode) CBP01940 Caenorhabditis briggsae (nematode) CE17565 Caenorhabditis elegans (worm) ENSCAFP00000011831 Canis familiaris (dog) CAGL0K02497g Candida glabrata (haploid yeast) Chro.40357 Cryptosporidium hominis (obligate parasite) ENSCINP00000025693 Ciona intestinalis (sea squirt) JA02743 Caenorhabditis japonica (nematode) CMT351C Cyanidioschyzon merolae (red alga) cn10286 Cryptococcus neoformans (yeast-like fungus) cgd4_3130 Cryptosporidium parvum (protozoan parasite) CPIJ011715 Culex pipens (mosquito) ENSCPOP00000011955 Cavia porcellus (guinea pig) 188065 Chlamidomonas reinhardtii (green alga) RP23705 Caenorhabditis remanei (nematode) ENSCSAVP00000008119 Ciona savignyi (sedentary tunicate) DDB0234038 Dictyostelium discoideum (amoeba) DEHA2E04004g Debaryomyces Hansenii (yeast) 300595 Daphnia pulex (daphnia) ENSDARP00000015326 Danio rerio (zebra fish) ENSECAP00000008564 Equus caballus (horse) XP_653440 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000010 Gymnopilus aculeatus (mushroom) ENSGALP00000002796 Gallus gallus (chicken) GL50803_14606 Giardia lamblia (flagellated protozoan) 75815 Hypsipyla robusta (cedar shoot borer) ENSP00000363574 Homo sapiens (human) ISCW009069-PA Ixodes scapularis (deer tick) KLLA0D02046g Kluyveromyces lactis (yeast) 206392 Lottia gigantea (owl limpet) LmjF36.0890 Leishmania major (virus) 20305 Monocosta brevicollis (choanoflagellate) ENSMODP00000024563 Monodelphis domestica (gray opossum) ENSMMUP00000023949 Macaca mulatta (rhesus monkey) ENSMUSP00000029142 Mus musculus (house mouse) 177965 Nematostella vectensis (starlet anemone) XP_001608239.1 Nasonia vitripennis (wasp) ENSOANP00000019838 Ornithorynchus anatinus (platypus) ENSORLP00000003634 Oryzias latipes (japanese killifish) LOC_Os07g44620.1 Oryza sativa (asian rice) 22707 Ostreococcus tauri (green alga) PF13_0178 Plasmodium falciparum (protozoal parasite) PHUM004133-PA Pediculus humanus (human body louse) PP13711 Pristionchus pacificus (nematode) 194687 Physcomitrella patens (moss) ENSPPYP00000012226 Pongo pygmaeus (orangutan) 71297 Phytophthora ramorum (sudden oak death pathogen) 108957 Phytophthora sojae (root rot pathogen) 719158 Populus trichocarpa (black cottonwood) ENSPTRP00000023044 Pan troglodytes (chimpanzee) PVX_082570 Plasmodium vivax (protozoal parasite) 149353 Sorghum bicolor (sorghum) YPR016C Saccharomyces cerevisiae (budding yeast) Smp_080740 Schistosoma mansoni (trematode parasite) SPCC1919.09 Schizosaccharomyces pombe (fission yeast) XP_785113.1 Strongylocentrotus purpuratus (purple sea urchin) 18785 Trichoplax adhaerens (metazoa) TA12585 Theileria annulata (apicomplexan parasite) XP_970112.1 Tribolium castaneum (red flour beetle) Tc00.1047053506679.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005401 Tetraodon nigroviridis (green spotted pufferfish) TP02_0333 Theileria parva (parasitic protozoan) 29782 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000226 Takifugu rubripes (pufferfish Takifugu) 119.m00105 Tetrahymena thermophila (ciliate protozoa) 87873.m00078 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000056385 Xenopus tropicalis (frog) YALI0E27940g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13633 NV10909 LH20928 ISCW009069 FBgn0208605 JGI_V11_300595 FBgn0074606 FBgn0132433 FBgn0130367 CPIJ011715 BGIBMGA009830 ACYPI002176 GB11906 AGAP001380 AAEL003661 PHUM465340 GLEAN_02553
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	12197 y1 w67c23; P{lacW}eIF6k13214 ytrk13214/CyO
Kyoto	111443 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}eIF6k13214 ytrk13214 /CyO y+
VDRC	v108094 P{KK101259}VIE-260B
Genomic Clones ( 1 )
	BACR05F24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08760
Other clones	DPiM_GH08760
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT21503 RE15409 RE22455 RH71809 SD16028 SD27968
Other clones	32958 569653 bs86b12 Dmel_dig_015994_0682_1830 EK143413 EK247508 EN15331
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034915 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37776
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: eIF6 CG17611 (Lasko, 2000)
Source for database merge of	Source for merge of: eIF6 anon-WO0172774.153 anon-WO0172774.155 (FlyBase, 1996-) Source for merge of: eIF6 l(2)k13214 (FlyBase, 1996-)
Additional comments	Source for merge of eIF6 anon-WO0172774.153 anon-WO0172774.155 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of eIF6 l(2)k13214 was a shared cDNA (date:030206). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_145105 RefSeq (Proteins) • NP_659573 DDBJ / EMBL / GenBank • AAF47074 AAM11041 AI109537 AQ026049 AW941716 AX260191 AX260193 AY094688 X97641 Entrez Gene - A searchable database of RefSeq genes. • 37776 UniProtKB/Swiss-Prot • P56538
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Translation initiation factor IF6 (IPR002769)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0034915 DRSC - Results from RNAi screens. • FBgn0034915 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034915 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17611-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034915 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37776 InParanoid A subset of ortholog calls from InParanoid. • AAEL003661-PA Aedes aegypti (mosquito) AGAP001380-PA Anopheles gambiae (mosquito) XP_392115.1 Apis mellifera (honey bee) XP_001946083.1 Acyrthosiphon pisum (pea aphid) At3g55620.1 Arabidopsis thaliana (wall cress) 30647 Batrachochytrium dendrobatidis (chytrid fungus) 127243 Branchiostoma floridae (lancelet) BGIBMGA009830-PA Bombyx mori (silk worm) ENSBTAP00000014966 Bos taurus (bovine) CAL0001603 Candida albicans (a form of yeast) CN14352 Caenorhabditis brenneri (small nematode) CBP01940 Caenorhabditis briggsae (nematode) CE17565 Caenorhabditis elegans (worm) ENSCAFP00000011831 Canis familiaris (dog) CAGL0K02497g Candida glabrata (haploid yeast) Chro.40357 Cryptosporidium hominis (obligate parasite) ENSCINP00000025693 Ciona intestinalis (sea squirt) JA02743 Caenorhabditis japonica (nematode) CMT351C Cyanidioschyzon merolae (red alga) cn10286 Cryptococcus neoformans (yeast-like fungus) cgd4_3130 Cryptosporidium parvum (protozoan parasite) CPIJ011715 Culex pipens (mosquito) ENSCPOP00000011955 Cavia porcellus (guinea pig) 188065 Chlamidomonas reinhardtii (green alga) RP23705 Caenorhabditis remanei (nematode) ENSCSAVP00000008119 Ciona savignyi (sedentary tunicate) DDB0234038 Dictyostelium discoideum (amoeba) DEHA2E04004g Debaryomyces Hansenii (yeast) 300595 Daphnia pulex (daphnia) ENSDARP00000015326 Danio rerio (zebra fish) ENSECAP00000008564 Equus caballus (horse) XP_653440 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000000010 Gymnopilus aculeatus (mushroom) ENSGALP00000002796 Gallus gallus (chicken) GL50803_14606 Giardia lamblia (flagellated protozoan) 75815 Hypsipyla robusta (cedar shoot borer) ENSP00000363574 Homo sapiens (human) ISCW009069-PA Ixodes scapularis (deer tick) KLLA0D02046g Kluyveromyces lactis (yeast) 206392 Lottia gigantea (owl limpet) LmjF36.0890 Leishmania major (virus) 20305 Monocosta brevicollis (choanoflagellate) ENSMODP00000024563 Monodelphis domestica (gray opossum) ENSMMUP00000023949 Macaca mulatta (rhesus monkey) ENSMUSP00000029142 Mus musculus (house mouse) 177965 Nematostella vectensis (starlet anemone) XP_001608239.1 Nasonia vitripennis (wasp) ENSOANP00000019838 Ornithorynchus anatinus (platypus) ENSORLP00000003634 Oryzias latipes (japanese killifish) LOC_Os07g44620.1 Oryza sativa (asian rice) 22707 Ostreococcus tauri (green alga) PF13_0178 Plasmodium falciparum (protozoal parasite) PHUM004133-PA Pediculus humanus (human body louse) PP13711 Pristionchus pacificus (nematode) 194687 Physcomitrella patens (moss) ENSPPYP00000012226 Pongo pygmaeus (orangutan) 71297 Phytophthora ramorum (sudden oak death pathogen) 108957 Phytophthora sojae (root rot pathogen) 719158 Populus trichocarpa (black cottonwood) ENSPTRP00000023044 Pan troglodytes (chimpanzee) PVX_082570 Plasmodium vivax (protozoal parasite) 149353 Sorghum bicolor (sorghum) YPR016C Saccharomyces cerevisiae (budding yeast) Smp_080740 Schistosoma mansoni (trematode parasite) SPCC1919.09 Schizosaccharomyces pombe (fission yeast) XP_785113.1 Strongylocentrotus purpuratus (purple sea urchin) 18785 Trichoplax adhaerens (metazoa) TA12585 Theileria annulata (apicomplexan parasite) XP_970112.1 Tribolium castaneum (red flour beetle) Tc00.1047053506679.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000005401 Tetraodon nigroviridis (green spotted pufferfish) TP02_0333 Theileria parva (parasitic protozoan) 29782 Thalassiosira pseudonana (marine diatom) ENSTRUP00000000226 Takifugu rubripes (pufferfish Takifugu) 119.m00105 Tetrahymena thermophila (ciliate protozoa) 87873.m00078 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000056385 Xenopus tropicalis (frog) YALI0E27940g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37776 modMine - Data generated by the modENCODE project. • FBgn0034915 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13633 NV10909 LH20928 ISCW009069 FBgn0208605 JGI_V11_300595 FBgn0074606 FBgn0132433 FBgn0130367 CPIJ011715 BGIBMGA009830 ACYPI002176 GB11906 AGAP001380 AAEL003661 PHUM465340 GLEAN_02553
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-WO0172774.153   anon-WO0172774.155   CG17611 (McKearin, 2000.8.3, Lasko, 2000, Keleman et al., 2009.8.5, Jäger and Dorner, 2010) DeIF6 (Ji et al., 2008) eif6 (Orian et al., 2003) eIF6 (Janody and Treisman, 2006, Christensen et al., 2008.9.3, Eulalio et al., 2007, Akdemir et al., 2007, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Pierce et al., 2008, Demontis and Perrimon, 2009, Jäger and Dorner, 2010) l(2)k13214 (Spradling et al., 1999, Beaton, 1997.12.27, ) unnamed (Kaiser, 1996.4.19)
Name Synonym	eIF6
Secondary FlyBase IDs
	FBgn0021890 FBgn0046444 FBgn0046445
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 ) Protein sequence record  ( 1 ) Patent  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Jäger and Dorner, 2010, RNA Biol. 7(3): 381--385 The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells. [FBrf0212181] Show all research papers ...