Gene Dmel\CG5339

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General Information

Symbol

Dmel\CG5339

Species

D. melanogaster

Name

Annotation symbol

CG5339

Feature type

protein_coding_gene

FlyBase ID

FBgn0034925

Gene Model Status

Current

Stock availability

2 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

60A9-60A9

Sequence location

2R:19,784,419..19,785,757 [-]

Genomic Maps

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Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG5339 (FBgn0034925). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DREV methyltransferase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628299_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG5339. Gene sequence location is 2R:19784419..19785757.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60A9-60A9

Limits computationally determined from genome sequence between P{lacW}ken^k11035&P{EP}CG17658^EP730 and P{EP}Tal^EP489&P{EP}CG3065^EP316

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG5339 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG5339-RA

FBtr0072220

NM_138002

1227

305

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG5339-PA

FBpp0072129

34.7

305

6.42

NP_611846

AAF47093

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

DREV methyltransferase (IPR007884)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9W1H1

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		133.1
Larval Midgut		123.2
Larval Hindgut		132.4
Larval Malpighian Tubules		326.2
Larval Fat Body		146
Larval Salivary Gland		202.3
Larval Trachea		163.625
Larval Carcass		96.875
Adult Head		102.3
Adult Eye		119.85
Adult Brain		112
Adult Thoracic-Abdominal Ganglion		89.5
Adult Crop		158.7
Adult Midgut		170
Adult Hindgut		163.6
Adult Malpighian Tubules		123.9
Adult Fat Body		146.4
Adult Salivary Gland		210.9
Adult Heart		191.575
Adult VirginFemale Spermatheca		178.8
Adult InseminatedFemale Spermatheca		155.6
Adult Ovary		406.1
Adult Testis		123.8
Adult Male Accessory Gland		85.4
Adult Carcass		140.5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	102.3
NA	Eye	119.85
NA	Brain	112
133.1	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	89.5
NA	Crop	158.7
123.2	Midgut	170
132.4	Hindgut	163.6
326.2	Malpighian Tubules	123.9
146	Fat Body	146.4
202.3	Salivary Gland	210.9
NA	Heart	191.575
163.625	Trachea	NA
NA	VirginFemale Spermatheca	178.8
NA	InseminatedFemale Spermatheca	155.6
NA	Ovary	406.1
NA	Testis	123.8
NA	Male Accessory Gland	85.4
96.875	Carcass	140.5

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		76
ovary, mated 4-day female		52
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		(76)
ovary, mated 4-day female		(52)
testis, mated 4-day male		(29)
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		76
ovary, mated 4-day female		52
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		76
ovary, mated 4-day female		52
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		76
ovary, mated 4-day female		52
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		(76)
ovary, mated 4-day female		(52)
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		76
ovary, mated 4-day female		52
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		26
central nervous system, larvae L3		14
central nervous system, pupae P8		15
head, virgin 1-day female		8
head, virgin 4-day female		5
head, virgin 20-day female		11
head, mated 1-day female		6
head, mated 4-day female		7
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		10
head, mated 20-day male		12
salivary gland, larvae L3 wandering		5
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		17
digestive system, 1-day adult		18
digestive system, 4-day adult		14
digestive system, 20-day adult		17
fat body, larvae L3 wandering		9
fat body, white prepupae		9
fat body, pupae P8		11
carcass, larvae L3 wandering		11
carcass, 1-day adult		5
carcass, 4-day adult		9
carcass, 20-day adult		11
ovary, virgin 4-day female		76
ovary, mated 4-day female		52
testis, mated 4-day male		29
accessory gland, mated 4-day male		10
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		45
adult female 30day		47
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(70)
embryo 02-04hr		(32)
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		(31)
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		(45)
adult female 30day		(47)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		45
adult female 30day		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		45
adult female 30day		47
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		45
adult female 30day		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(70)
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		(45)
adult female 30day		(47)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		45
adult female 30day		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		70
embryo 02-04hr		32
embryo 04-06hr		17
embryo 06-08hr		21
embryo 08-10hr		22
embryo 10-12hr		31
embryo 12-14hr		16
embryo 14-16hr		13
embryo 16-18hr		9
embryo 18-20hr		10
embryo 20-22hr		9
embryo 22-24hr		8
larva L1		12
larva L2		14
larva L3 12hr old		14
larva L3 puffstage 1-2		11
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		15
white prepupae 12hr		13
white prepupae 24hr		15
pupae 2d postWPP		15
pupae 3d postWPP		11
pupae 4d postWPP		10
adult male 01day		13
adult male 05day		16
adult male 30day		15
adult female 01day		26
adult female 05day		45
adult female 30day		47
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		42
Schneider line 2 Sg4		51
embryonic 1182-4H		39
embryonic GM2		32
embryonic Kc167		32
embryonic S1		66
embryonic S3		44
leg disc CME L1		46
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		38
wing disc ML-DmD16-c3		33
wing disc ML-DmD21		65
wing disc ML-DmD32		46
haltere disc ML-DmD17-c3		100
eye-antennal disc ML-DmD11		51
antennal disc ML-DmD20-c5		84
mixed discs ML-DmD4-c1		38
CNS ML-DmBG1-c1		38
CNS ML-DmBG2-c2		40
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(42)
Schneider line 2 Sg4		(51)
embryonic 1182-4H		(39)
embryonic GM2		(32)
embryonic Kc167		(32)
embryonic S1		(66)
embryonic S3		(44)
leg disc CME L1		(46)
wing disc CME-W2		(29)
wing disc ML-DmD8		(29)
wing disc ML-DmD9		(38)
wing disc ML-DmD16-c3		(33)
wing disc ML-DmD21		(65)
wing disc ML-DmD32		(46)
haltere disc ML-DmD17-c3		(100)
eye-antennal disc ML-DmD11		(51)
antennal disc ML-DmD20-c5		(84)
mixed discs ML-DmD4-c1		(38)
CNS ML-DmBG1-c1		(38)
CNS ML-DmBG2-c2		(40)
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		42
Schneider line 2 Sg4		51
embryonic 1182-4H		39
embryonic GM2		32
embryonic Kc167		32
embryonic S1		66
embryonic S3		44
leg disc CME L1		46
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		38
wing disc ML-DmD16-c3		33
wing disc ML-DmD21		65
wing disc ML-DmD32		46
haltere disc ML-DmD17-c3		100
eye-antennal disc ML-DmD11		51
antennal disc ML-DmD20-c5		84
mixed discs ML-DmD4-c1		38
CNS ML-DmBG1-c1		38
CNS ML-DmBG2-c2		40
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		42
Schneider line 2 Sg4		51
embryonic 1182-4H		39
embryonic GM2		32
embryonic Kc167		32
embryonic S1		66
embryonic S3		44
leg disc CME L1		46
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		38
wing disc ML-DmD16-c3		33
wing disc ML-DmD21		65
wing disc ML-DmD32		46
haltere disc ML-DmD17-c3		100
eye-antennal disc ML-DmD11		51
antennal disc ML-DmD20-c5		84
mixed discs ML-DmD4-c1		38
CNS ML-DmBG1-c1		38
CNS ML-DmBG2-c2		40
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		42
Schneider line 2 Sg4		51
embryonic 1182-4H		39
embryonic GM2		32
embryonic Kc167		32
embryonic S1		66
embryonic S3		44
leg disc CME L1		46
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		38
wing disc ML-DmD16-c3		33
wing disc ML-DmD21		65
wing disc ML-DmD32		46
haltere disc ML-DmD17-c3		100
eye-antennal disc ML-DmD11		51
antennal disc ML-DmD20-c5		84
mixed discs ML-DmD4-c1		38
CNS ML-DmBG1-c1		38
CNS ML-DmBG2-c2		40
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(42)
Schneider line 2 Sg4		(51)
embryonic 1182-4H		(39)
embryonic GM2		32
embryonic Kc167		32
embryonic S1		(66)
embryonic S3		(44)
leg disc CME L1		(46)
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		(38)
wing disc ML-DmD16-c3		(33)
wing disc ML-DmD21		(65)
wing disc ML-DmD32		(46)
haltere disc ML-DmD17-c3		(100)
eye-antennal disc ML-DmD11		(51)
antennal disc ML-DmD20-c5		(84)
mixed discs ML-DmD4-c1		(38)
CNS ML-DmBG1-c1		(38)
CNS ML-DmBG2-c2		(40)
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		42
Schneider line 2 Sg4		51
embryonic 1182-4H		39
embryonic GM2		32
embryonic Kc167		32
embryonic S1		66
embryonic S3		44
leg disc CME L1		46
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		38
wing disc ML-DmD16-c3		33
wing disc ML-DmD21		65
wing disc ML-DmD32		46
haltere disc ML-DmD17-c3		100
eye-antennal disc ML-DmD11		51
antennal disc ML-DmD20-c5		84
mixed discs ML-DmD4-c1		38
CNS ML-DmBG1-c1		38
CNS ML-DmBG2-c2		40
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		42
Schneider line 2 Sg4		51
embryonic 1182-4H		39
embryonic GM2		32
embryonic Kc167		32
embryonic S1		66
embryonic S3		44
leg disc CME L1		46
wing disc CME-W2		29
wing disc ML-DmD8		29
wing disc ML-DmD9		38
wing disc ML-DmD16-c3		33
wing disc ML-DmD21		65
wing disc ML-DmD32		46
haltere disc ML-DmD17-c3		100
eye-antennal disc ML-DmD11		51
antennal disc ML-DmD20-c5		84
mixed discs ML-DmD4-c1		38
CNS ML-DmBG1-c1		38
CNS ML-DmBG2-c2		40
tumorous blood cells mbn2		17
ovary fGS/OSS		19
ovary OSC		16
ovary OSS		6
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		45
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		(29)
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		(36)
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		(45)
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(34)
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		(27)
Paraquat 10 mM 48 hrs, 4-day adult		(27)
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		45
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		45
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		45
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		(36)
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		(45)
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(34)
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		45
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		16
cold shock, 4-day adult		12
heat shock, 4-day adult		21
Cadmium 50 mM 6 hrs, larvae L3		29
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		20
Cadmium 100 mM 48 hrs, 4-day adult		36
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		15
Zinc 5 mM 12 hrs, larvae L3		9
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		45
Ethanol 5% 3 hrs, larvae L3		18
Ethanol 10% 3 hrs, larvae L3		15
Caffeine 1.5 mg/ml 4 hrs, larvae L3		16
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		34
Caffeine 25 mg/ml 48 hrs, 4-day adult		14
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		27
Rotenone 2 μg 12 hrs, larvae L3		25
Rotenone 8 μg 12 hrs, larvae L3		22
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

GH17155

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0034925

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG5339-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG5339^GD11614

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG5339	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG5339	Mutagen	Stocks	Known lesion
CG5339^GD11614	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG5339^KK107559	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG5339^NIG.5339R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2R)Exel6080

(Ryder, 2004.4.26)

Partially disrupted in

Df(2R)Lpt¹

(Chauhan et al., 2012)

Df(2R)Lpt²

(Chauhan et al., 2012)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD11614}

P{KK107559}

P{NIG.5339R}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG5339 allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0034925

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

37794

Orthologs

OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6P8G46

Dipteran inclusive ortholog search

EOG680J5G

Insect inclusive ortholog search

EOG64QRXH

Arthropod inclusive ortholog search

EOG69S4NV

Metazoa inclusive ortholog search

EOG6NSG53

Orthologs in Drosophila Species (EOG6P8G46)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18814

Drosophila persimilis

Dper\GL10919

Drosophila willistoni

Dwil\GK15857

Drosophila virilis

Dvir\GJ21879

Drosophila mojavensis

Dmoj\GI20718

Drosophila grimshawi

Dgri\GH20191

Orthologs in non-Drosophila Dipterans (EOG680J5G)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007301

Anopheles gambiae

Malaria mosquito

Agam\AGAP003602

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ015524

Orthologs in non-Dipteran Insects (EOG64QRXH)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB54032

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH17496

Atta cephalotes

Leafcutter ant

Acep\ACEP22218

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO18477

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL18946

Linepithema humile

Argentine ant

Lhum\LH22746

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB23465

Solenopsis invicta

Red fire ant

Sinv\SINV19133

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000457

Bombyx mori

Silkmoth

Bmor\BGIBMGA012024

Pediculus humanus

Human body louse

Phum\PHUM191300

Tribolium castaneum

Red flour beetle

Tcas\TC003894

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (EOG6NSG53)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\T03G11.6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_027766gn

Danio rerio

Zebrafish

Drer\zgc:153060

Xenopus tropicalis

Western clawed frog

Xtro\mettl9

Gallus gallus

Domestic chicken

Ggal\METTL9

Mus musculus

House mouse

Mmus\Mettl9

Rattus norvegicus

Norway rat

Rnor\ENSRNOG00000027457

Rattus norvegicus

Norway rat

Rnor\LOC100362944

Homo sapiens

Human

Hsap\METTL9

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\METTL9

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA18814

Drosophila persimilis

Dper\GL10919

Drosophila willistoni

Dwil\GK15857

Drosophila virilis

Dvir\GJ21879

Drosophila mojavensis

Dmoj\GI20718

Drosophila grimshawi

Dgri\GH20191

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v101322

P{KK107559}VIE-260B

v22075

w¹¹¹⁸; P{GD11614}v22075/CyO

Genomic Clones ( 1 )

BACR05F24

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 24 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

GH17155

Other clones

DPiM_GH17155

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0034925

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

37794

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_138002

RefSeq (Proteins)

•

NP_611846

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

37794

UniProtKB/TrEMBL

•

Q9W1H1

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

DREV methyltransferase (IPR007884)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

GH17155

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0034925

DRSC - Results from RNAi screens.

•

FBgn0034925

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0034925

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG5339-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0034925

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

37794

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

37794

modMine - Data generated by the modENCODE project.

•

FBgn0034925

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

CG5339

(Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

drev

(Chauhan et al., 2012)

Name Synonym

Secondary FlyBase IDs

References ( 11 )

Research paper

Chauhan et al., 2012, Development 139(11): 1997--2008: Histone Recognition and Nuclear Receptor Co-Activator Functions of Drosophila Cara Mitad, a Homolog of the N-Terminal Portion of Mammalian MLL2 and MLL3. [FBrf0218263]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]

Personal communication to FlyBase

Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]