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Gene Dmel\Gadd34

General Information
Symbol	Dmel\Gadd34	Species	D. melanogaster
Name		Annotation symbol	CG3825
Feature type	protein_coding_gene	FlyBase ID	FBgn0034948
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	GADD34
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60A15-60A16	Sequence location	2R:19,863,124..19,864,801 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\Gadd34 (CG3825, FBgn0034948). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein phosphatase 1 binding. The biological processes in which it is involved are not known. 7 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein phosphatase 1, regulatory subunit 15A/B, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638701_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG3825. Gene sequence location is 2R:19863124..19864801.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60A15-60A16   Limits computationally determined from genome sequence between P{EP}TalEP489&P{EP}CG3065EP316 and P{lacW}Phmk07623&P{lacW}tsrk05633
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Gadd34 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gadd34-RA FBtr0072204  NM_138019   1618   317
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gadd34-PA   FBpp0072113   36.0   317   4.86     NP_611863   AAF47124
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein phosphatase 1, regulatory subunit 15A/B, C-terminal (IPR019523)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201969   AA440042   AA567450   AA940970   AE013599 AAF47124   AI134303   AI511768   AI512591   AI515019   AI517874   AI520625   AI542872   AI543133   AI946490   AY051450 AAK92874   BE977249   BF493946   BF504383   BI166142   BI166519   BI216108   BI238845   BI239856   BI240500   BI241898   BI356509   BI361425   BI623464   BI624541   BI637410   BI639106   BP549561   CO155950   CO303795   CO305291   CO311384   CO328577   CO332419   CO340644   EC064919   EC068660   EC077569   EC083972   EC216429   EC226200   EC236843   EC239587   EC246876   EC255870   EV597971   GH750459   GH815802   GH872898   GH916747   GH938069
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W1E4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye    878 Adult Brain    595 Adult Thoracic-Abdominal Ganglion    596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis    513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye  (878) Adult Brain  (595) Adult Thoracic-Abdominal Ganglion  (596.4) Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis  513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye    878 Adult Brain    595 Adult Thoracic-Abdominal Ganglion    596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis    513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye    878 Adult Brain    595 Adult Thoracic-Abdominal Ganglion    596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis    513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye    878 Adult Brain    595 Adult Thoracic-Abdominal Ganglion    596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis    513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye  (878) Adult Brain  595 Adult Thoracic-Abdominal Ganglion  596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis  513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye    878 Adult Brain    595 Adult Thoracic-Abdominal Ganglion    596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis    513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    341.475 Larval Midgut    372.4 Larval Hindgut    280.9 Larval Malpighian Tubules    438.2 Larval Fat Body    283.9 Larval Salivary Gland    268.6 Larval Trachea    273.5 Larval Carcass    249.7 Adult Head    468 Adult Eye    878 Adult Brain    595 Adult Thoracic-Abdominal Ganglion    596.4 Adult Crop    454.8 Adult Midgut    410 Adult Hindgut    442.4 Adult Malpighian Tubules    472.9 Adult Fat Body    320.9 Adult Salivary Gland    472 Adult Heart    346.175 Adult VirginFemale Spermatheca    404.6 Adult InseminatedFemale Spermatheca    339.9 Adult Ovary    474.5 Adult Testis    513.5 Adult Male Accessory Gland    236.3 Adult Carcass    427.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    468   NA  Eye    878   NA  Brain    595   341.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    596.4   NA  Crop    454.8   372.4  Midgut    410   280.9  Hindgut    442.4   438.2  Malpighian Tubules    472.9   283.9  Fat Body    320.9   268.6  Salivary Gland    472   NA  Heart    346.175   273.5  Trachea    NA   NA  VirginFemale Spermatheca    404.6   NA  InseminatedFemale Spermatheca    339.9   NA  Ovary    474.5   NA  Testis    513.5   NA  Male Accessory Gland    236.3   249.7  Carcass    427.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    46 head, virgin 4-day female    38 head, virgin 20-day female    41 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    29 head, mated 1-day male    78 head, mated 4-day male    73 head, mated 20-day male    73 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    46 digestive system, 4-day adult    35 digestive system, 20-day adult    46 fat body, larvae L3 wandering    12 fat body, white prepupae    30 fat body, pupae P8    51 carcass, larvae L3 wandering    29 carcass, 1-day adult    45 carcass, 4-day adult    41 carcass, 20-day adult    34 ovary, virgin 4-day female    78 ovary, mated 4-day female    68 testis, mated 4-day male    82 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (56) central nervous system, larvae L3  (35) central nervous system, pupae P8  (33) head, virgin 1-day female  (46) head, virgin 4-day female  (38) head, virgin 20-day female  (41) head, mated 1-day female  (40) head, mated 4-day female  (47) head, mated 20-day female  (29) head, mated 1-day male  (78) head, mated 4-day male  (73) head, mated 20-day male  (73) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae  (44) digestive system, larvae L3 wandering  (60) digestive system, 1-day adult  (46) digestive system, 4-day adult  (35) digestive system, 20-day adult  (46) fat body, larvae L3 wandering    12 fat body, white prepupae  (30) fat body, pupae P8  (51) carcass, larvae L3 wandering  (29) carcass, 1-day adult  (45) carcass, 4-day adult  (41) carcass, 20-day adult  (34) ovary, virgin 4-day female  (78) ovary, mated 4-day female  (68) testis, mated 4-day male  (82) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    46 head, virgin 4-day female    38 head, virgin 20-day female    41 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    29 head, mated 1-day male    78 head, mated 4-day male    73 head, mated 20-day male    73 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    46 digestive system, 4-day adult    35 digestive system, 20-day adult    46 fat body, larvae L3 wandering    12 fat body, white prepupae    30 fat body, pupae P8    51 carcass, larvae L3 wandering    29 carcass, 1-day adult    45 carcass, 4-day adult    41 carcass, 20-day adult    34 ovary, virgin 4-day female    78 ovary, mated 4-day female    68 testis, mated 4-day male    82 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    46 head, virgin 4-day female    38 head, virgin 20-day female    41 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    29 head, mated 1-day male    78 head, mated 4-day male    73 head, mated 20-day male    73 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    46 digestive system, 4-day adult    35 digestive system, 20-day adult    46 fat body, larvae L3 wandering    12 fat body, white prepupae    30 fat body, pupae P8    51 carcass, larvae L3 wandering    29 carcass, 1-day adult    45 carcass, 4-day adult    41 carcass, 20-day adult    34 ovary, virgin 4-day female    78 ovary, mated 4-day female    68 testis, mated 4-day male    82 accessory gland, mated 4-day male    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    46 head, virgin 4-day female    38 head, virgin 20-day female    41 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    29 head, mated 1-day male    78 head, mated 4-day male    73 head, mated 20-day male    73 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    46 digestive system, 4-day adult    35 digestive system, 20-day adult    46 fat body, larvae L3 wandering    12 fat body, white prepupae    30 fat body, pupae P8    51 carcass, larvae L3 wandering    29 carcass, 1-day adult    45 carcass, 4-day adult    41 carcass, 20-day adult    34 ovary, virgin 4-day female    78 ovary, mated 4-day female    68 testis, mated 4-day male    82 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (56) central nervous system, larvae L3  (35) central nervous system, pupae P8  (33) head, virgin 1-day female  (46) head, virgin 4-day female  (38) head, virgin 20-day female  (41) head, mated 1-day female  (40) head, mated 4-day female  (47) head, mated 20-day female  29 head, mated 1-day male  (78) head, mated 4-day male  (73) head, mated 20-day male  (73) salivary gland, larvae L3 wandering    15 salivary gland, white prepupae  (44) digestive system, larvae L3 wandering  (60) digestive system, 1-day adult  (46) digestive system, 4-day adult  (35) digestive system, 20-day adult  (46) fat body, larvae L3 wandering    12 fat body, white prepupae  30 fat body, pupae P8  (51) carcass, larvae L3 wandering  29 carcass, 1-day adult  (45) carcass, 4-day adult  (41) carcass, 20-day adult  (34) ovary, virgin 4-day female  (78) ovary, mated 4-day female  (68) testis, mated 4-day male  (82) accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    46 head, virgin 4-day female    38 head, virgin 20-day female    41 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    29 head, mated 1-day male    78 head, mated 4-day male    73 head, mated 20-day male    73 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    46 digestive system, 4-day adult    35 digestive system, 20-day adult    46 fat body, larvae L3 wandering    12 fat body, white prepupae    30 fat body, pupae P8    51 carcass, larvae L3 wandering    29 carcass, 1-day adult    45 carcass, 4-day adult    41 carcass, 20-day adult    34 ovary, virgin 4-day female    78 ovary, mated 4-day female    68 testis, mated 4-day male    82 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    56 central nervous system, larvae L3    35 central nervous system, pupae P8    33 head, virgin 1-day female    46 head, virgin 4-day female    38 head, virgin 20-day female    41 head, mated 1-day female    40 head, mated 4-day female    47 head, mated 20-day female    29 head, mated 1-day male    78 head, mated 4-day male    73 head, mated 20-day male    73 salivary gland, larvae L3 wandering    15 salivary gland, white prepupae    44 digestive system, larvae L3 wandering    60 digestive system, 1-day adult    46 digestive system, 4-day adult    35 digestive system, 20-day adult    46 fat body, larvae L3 wandering    12 fat body, white prepupae    30 fat body, pupae P8    51 carcass, larvae L3 wandering    29 carcass, 1-day adult    45 carcass, 4-day adult    41 carcass, 20-day adult    34 ovary, virgin 4-day female    78 ovary, mated 4-day female    68 testis, mated 4-day male    82 accessory gland, mated 4-day male    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    96 embryo 04-06hr    65 embryo 06-08hr    65 embryo 08-10hr    73 embryo 10-12hr    77 embryo 12-14hr    67 embryo 14-16hr    65 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    57 embryo 22-24hr    67 larva L1    37 larva L2    29 larva L3 12hr old    26 larva L3 puffstage 1-2    27 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    48 white prepupae new    48 white prepupae 12hr    62 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    53 pupae 4d postWPP    65 adult male 01day    67 adult male 05day    68 adult male 30day    65 adult female 01day    55 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (76) embryo 02-04hr  (96) embryo 04-06hr  (65) embryo 06-08hr  (65) embryo 08-10hr  (73) embryo 10-12hr  (77) embryo 12-14hr  (67) embryo 14-16hr  (65) embryo 16-18hr  (68) embryo 18-20hr  (57) embryo 20-22hr  (57) embryo 22-24hr  (67) larva L1  (37) larva L2  (29) larva L3 12hr old  26 larva L3 puffstage 1-2  (27) larva L3 puffstage 3-6  (35) larva L3 puffstage 7-9  (48) white prepupae new  (48) white prepupae 12hr  (62) white prepupae 24hr  (48) pupae 2d postWPP  (49) pupae 3d postWPP  (53) pupae 4d postWPP  (65) adult male 01day  (67) adult male 05day  (68) adult male 30day  (65) adult female 01day  (55) adult female 05day  (52) adult female 30day  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    96 embryo 04-06hr    65 embryo 06-08hr    65 embryo 08-10hr    73 embryo 10-12hr    77 embryo 12-14hr    67 embryo 14-16hr    65 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    57 embryo 22-24hr    67 larva L1    37 larva L2    29 larva L3 12hr old    26 larva L3 puffstage 1-2    27 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    48 white prepupae new    48 white prepupae 12hr    62 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    53 pupae 4d postWPP    65 adult male 01day    67 adult male 05day    68 adult male 30day    65 adult female 01day    55 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    96 embryo 04-06hr    65 embryo 06-08hr    65 embryo 08-10hr    73 embryo 10-12hr    77 embryo 12-14hr    67 embryo 14-16hr    65 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    57 embryo 22-24hr    67 larva L1    37 larva L2    29 larva L3 12hr old    26 larva L3 puffstage 1-2    27 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    48 white prepupae new    48 white prepupae 12hr    62 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    53 pupae 4d postWPP    65 adult male 01day    67 adult male 05day    68 adult male 30day    65 adult female 01day    55 adult female 05day    52 adult female 30day    52 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    96 embryo 04-06hr    65 embryo 06-08hr    65 embryo 08-10hr    73 embryo 10-12hr    77 embryo 12-14hr    67 embryo 14-16hr    65 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    57 embryo 22-24hr    67 larva L1    37 larva L2    29 larva L3 12hr old    26 larva L3 puffstage 1-2    27 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    48 white prepupae new    48 white prepupae 12hr    62 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    53 pupae 4d postWPP    65 adult male 01day    67 adult male 05day    68 adult male 30day    65 adult female 01day    55 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (76) embryo 02-04hr  (96) embryo 04-06hr  (65) embryo 06-08hr  (65) embryo 08-10hr  (73) embryo 10-12hr  (77) embryo 12-14hr  (67) embryo 14-16hr  (65) embryo 16-18hr  (68) embryo 18-20hr  (57) embryo 20-22hr  (57) embryo 22-24hr  (67) larva L1  (37) larva L2  29 larva L3 12hr old  26 larva L3 puffstage 1-2  27 larva L3 puffstage 3-6  (35) larva L3 puffstage 7-9  (48) white prepupae new  (48) white prepupae 12hr  (62) white prepupae 24hr  (48) pupae 2d postWPP  (49) pupae 3d postWPP  (53) pupae 4d postWPP  (65) adult male 01day  (67) adult male 05day  (68) adult male 30day  (65) adult female 01day  (55) adult female 05day  (52) adult female 30day  (52) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    96 embryo 04-06hr    65 embryo 06-08hr    65 embryo 08-10hr    73 embryo 10-12hr    77 embryo 12-14hr    67 embryo 14-16hr    65 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    57 embryo 22-24hr    67 larva L1    37 larva L2    29 larva L3 12hr old    26 larva L3 puffstage 1-2    27 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    48 white prepupae new    48 white prepupae 12hr    62 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    53 pupae 4d postWPP    65 adult male 01day    67 adult male 05day    68 adult male 30day    65 adult female 01day    55 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    76 embryo 02-04hr    96 embryo 04-06hr    65 embryo 06-08hr    65 embryo 08-10hr    73 embryo 10-12hr    77 embryo 12-14hr    67 embryo 14-16hr    65 embryo 16-18hr    68 embryo 18-20hr    57 embryo 20-22hr    57 embryo 22-24hr    67 larva L1    37 larva L2    29 larva L3 12hr old    26 larva L3 puffstage 1-2    27 larva L3 puffstage 3-6    35 larva L3 puffstage 7-9    48 white prepupae new    48 white prepupae 12hr    62 white prepupae 24hr    48 pupae 2d postWPP    49 pupae 3d postWPP    53 pupae 4d postWPP    65 adult male 01day    67 adult male 05day    68 adult male 30day    65 adult female 01day    55 adult female 05day    52 adult female 30day    52 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    140 Schneider line 2 Sg4    45 embryonic 1182-4H    73 embryonic GM2    91 embryonic Kc167    70 embryonic S1    143 embryonic S3    46 leg disc CME L1    64 wing disc CME-W2    47 wing disc ML-DmD8    48 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    79 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    92 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    84 ovary fGS/OSS    68 ovary OSC    52 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (140) Schneider line 2 Sg4  (45) embryonic 1182-4H  (73) embryonic GM2  (91) embryonic Kc167  (70) embryonic S1  (143) embryonic S3  (46) leg disc CME L1  (64) wing disc CME-W2  (47) wing disc ML-DmD8  (48) wing disc ML-DmD9  (76) wing disc ML-DmD16-c3  (51) wing disc ML-DmD21  (79) wing disc ML-DmD32  (45) haltere disc ML-DmD17-c3  (92) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (47) CNS ML-DmBG1-c1  (68) CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (84) ovary fGS/OSS  (68) ovary OSC  (52) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (140) Schneider line 2 Sg4    45 embryonic 1182-4H    73 embryonic GM2    91 embryonic Kc167    70 embryonic S1  (143) embryonic S3    46 leg disc CME L1    64 wing disc CME-W2    47 wing disc ML-DmD8    48 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    79 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    92 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    84 ovary fGS/OSS    68 ovary OSC    52 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    140 Schneider line 2 Sg4    45 embryonic 1182-4H    73 embryonic GM2    91 embryonic Kc167    70 embryonic S1    143 embryonic S3    46 leg disc CME L1    64 wing disc CME-W2    47 wing disc ML-DmD8    48 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    79 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    92 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    84 ovary fGS/OSS    68 ovary OSC    52 ovary OSS    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    140 Schneider line 2 Sg4    45 embryonic 1182-4H    73 embryonic GM2    91 embryonic Kc167    70 embryonic S1    143 embryonic S3    46 leg disc CME L1    64 wing disc CME-W2    47 wing disc ML-DmD8    48 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    79 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    92 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    84 ovary fGS/OSS    68 ovary OSC    52 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (140) Schneider line 2 Sg4  (45) embryonic 1182-4H  (73) embryonic GM2  (91) embryonic Kc167  (70) embryonic S1  (143) embryonic S3  (46) leg disc CME L1  (64) wing disc CME-W2  (47) wing disc ML-DmD8  (48) wing disc ML-DmD9  (76) wing disc ML-DmD16-c3  (51) wing disc ML-DmD21  (79) wing disc ML-DmD32  (45) haltere disc ML-DmD17-c3  (92) eye-antennal disc ML-DmD11  (47) antennal disc ML-DmD20-c5  (43) mixed discs ML-DmD4-c1  (47) CNS ML-DmBG1-c1  (68) CNS ML-DmBG2-c2  (66) tumorous blood cells mbn2  (84) ovary fGS/OSS  (68) ovary OSC  (52) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  140 Schneider line 2 Sg4    45 embryonic 1182-4H    73 embryonic GM2    91 embryonic Kc167    70 embryonic S1  143 embryonic S3    46 leg disc CME L1    64 wing disc CME-W2    47 wing disc ML-DmD8    48 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    79 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    92 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    84 ovary fGS/OSS    68 ovary OSC    52 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    140 Schneider line 2 Sg4    45 embryonic 1182-4H    73 embryonic GM2    91 embryonic Kc167    70 embryonic S1    143 embryonic S3    46 leg disc CME L1    64 wing disc CME-W2    47 wing disc ML-DmD8    48 wing disc ML-DmD9    76 wing disc ML-DmD16-c3    51 wing disc ML-DmD21    79 wing disc ML-DmD32    45 haltere disc ML-DmD17-c3    92 eye-antennal disc ML-DmD11    47 antennal disc ML-DmD20-c5    43 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    68 CNS ML-DmBG2-c2    66 tumorous blood cells mbn2    84 ovary fGS/OSS    68 ovary OSC    52 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    33 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    71 Paraquat 10 mM 48 hrs, 4-day adult    86 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (51) cold shock, 4-day adult  (33) heat shock, 4-day adult  (46) Cadmium 50 mM 6 hrs, larvae L3  (32) Cadmium 50 mM 12 hrs, larvae L3  (34) Cadmium 50 mM 48 hrs, 4-day adult  (48) Cadmium 100 mM 48 hrs, 4-day adult  (75) Copper 0.5 mM 12 hrs, larvae L3  (35) Copper 15 mM 48 hrs, 4-day adult  (37) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  (36) Ethanol 2.5% 3 hrs, larvae L3  (81) Ethanol 5% 3 hrs, larvae L3  (31) Ethanol 10% 3 hrs, larvae L3  (29) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (29) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult  (41) Paraquat 5 mM 48 hrs, 4-day adult  (71) Paraquat 10 mM 48 hrs, 4-day adult  (86) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    33 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    71 Paraquat 10 mM 48 hrs, 4-day adult    86 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    33 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    71 Paraquat 10 mM 48 hrs, 4-day adult    86 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    33 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    71 Paraquat 10 mM 48 hrs, 4-day adult    86 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (51) cold shock, 4-day adult  (33) heat shock, 4-day adult  (46) Cadmium 50 mM 6 hrs, larvae L3  32 Cadmium 50 mM 12 hrs, larvae L3  (34) Cadmium 50 mM 48 hrs, 4-day adult  (48) Cadmium 100 mM 48 hrs, 4-day adult  (75) Copper 0.5 mM 12 hrs, larvae L3  (35) Copper 15 mM 48 hrs, 4-day adult  (37) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  (36) Ethanol 2.5% 3 hrs, larvae L3  (81) Ethanol 5% 3 hrs, larvae L3  31 Ethanol 10% 3 hrs, larvae L3  29 Caffeine 1.5 mg/ml 4 hrs, larvae L3  29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (65) Caffeine 25 mg/ml 48 hrs, 4-day adult  (41) Paraquat 5 mM 48 hrs, 4-day adult  (71) Paraquat 10 mM 48 hrs, 4-day adult  (86) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    33 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    71 Paraquat 10 mM 48 hrs, 4-day adult    86 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    51 cold shock, 4-day adult    33 heat shock, 4-day adult    46 Cadmium 50 mM 6 hrs, larvae L3    32 Cadmium 50 mM 12 hrs, larvae L3    34 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    75 Copper 0.5 mM 12 hrs, larvae L3    35 Copper 15 mM 48 hrs, 4-day adult    37 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    36 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    31 Ethanol 10% 3 hrs, larvae L3    29 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    65 Caffeine 25 mg/ml 48 hrs, 4-day adult    41 Paraquat 5 mM 48 hrs, 4-day adult    71 Paraquat 10 mM 48 hrs, 4-day adult    86 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH11727 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034948 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3825-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Gadd34GD5953 viable Gadd34e02638 Sterility Allele fertile Gadd34e02638 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Gadd34GD5953 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Gadd34GD5953
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Gadd34 Class Mutagen Stocks Known lesion Gadd34e02638 piggyBac transposase 2 -- Gadd34G18907 P-element activity 1 -- Gadd34HP20979 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gadd34 Class Mutagen Stocks Known lesion Gadd34GD5953 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gadd34HMS00811 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gadd34KK104106 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Gadd34NIG.3825R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6080 (Ryder, 2004.4.26) Df(2R)Exel7182 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.3825R} NA P{TRiP.HMS00811} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Gadd34e02638 NA insertion of mobile activating element P{EP}Gadd34G18907 NA P{EPg}Gadd34HP20979 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
protein phosphatase 1 binding inferred from physical interaction with flw (Bennett et al., 2006) inferred from physical interaction with Pp1-13C (Bennett et al., 2006) inferred from physical interaction with Pp1-87B (Bennett et al., 2006) inferred from physical interaction with Pp1α-96A (Bennett et al., 2006)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Gadd34 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Arc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Arpc3A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG12012 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG12112 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG1307 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG13887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG1458 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG17528 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG18522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG33523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG3800 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG40042 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG4729 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG8142 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CG8478 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Chd64 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - CoVb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Cyp12d1-p anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Cyp6d4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Dpck anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Elongin-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Gie anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - HLH106 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Hsp70Ba anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Jra anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - MRP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Prosα4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Prosβ4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Prosβ6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - RpS10a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Rpt2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Sc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Snap25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Tom20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - Vap-33-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - alt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - bor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - eIF-2β anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - foi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - gish anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - l(2)03709 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - msn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - opa1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - sec63 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - sqh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - stc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - sun anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Gadd34 - εCOP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gadd34 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63407 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034948 DroID - A comprehensive database of gene and protein interactions. • FBgn0034948 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37820
Orthologs
OrthoDB Orthologs (30) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68WCN6 Dipteran inclusive ortholog search EOG61RQ3V Insect inclusive ortholog search EOG69W1BJ Arthropod inclusive ortholog search EOG69S4PG Metazoa inclusive ortholog search EOG6QZMH6
Orthologs in Drosophila Species (EOG68WCN6)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gadd34     Drosophila simulans   Dsim\GD24987 Y   Drosophila sechellia   Dsec\GM15484 Y   Drosophila erecta   Dere\GG19970 Y   Drosophila yakuba   Dyak\GE11502 Y   Drosophila ananassae   Dana\GF12046 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17713 Y   Drosophila persimilis   Dper\GL10438 Y   Drosophila willistoni   Dwil\GK15845 Y   Drosophila virilis   Dvir\GJ21892 Y   Drosophila mojavensis   Dmoj\GI20700 Y   Drosophila grimshawi   Dgri\GH20179 Y
Orthologs in non-Drosophila Dipterans (EOG61RQ3V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000235   Anopheles gambiae Malaria mosquito  Agam\AGAP004848   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ009944
Orthologs in non-Dipteran Insects (EOG69W1BJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53619   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000137   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10047   Atta cephalotes Leafcutter ant  Acep\ACEP19480   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16557   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19342   Linepithema humile Argentine ant  Lhum\LH17127   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22367   Solenopsis invicta Red fire ant  Sinv\SINV14661   Bombyx mori Silkmoth  Bmor\BGIBMGA011143   Pediculus humanus Human body louse  Phum\PHUM424140   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15594
Orthologs in non-Insect Arthropods (EOG69S4PG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW015696
Orthologs in non-Arthropod Metazoa (EOG6QZMH6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\si:ch211-107o23.1   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000030234
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24987 Drosophila sechellia Dsec\GM15484 Drosophila erecta Dere\GG19970 Drosophila yakuba Dyak\GE11502 Drosophila ananassae Dana\GF12046 Drosophila pseudoobscura pseudoobscura Dpse\GA17713 Drosophila persimilis Dper\GL10438 Drosophila willistoni Dwil\GK15845 Drosophila virilis Dvir\GJ21892 Drosophila mojavensis Dmoj\GI20700 Drosophila grimshawi Dgri\GH20179
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	18070 w1118; PBac{RB}Gadd34e02638 26945 y1 w*; P{EP}Gadd34G18907 33011 y1 sc* v1; P{TRiP.HMS00811}attP2 22330 y1 w*; P{EPg}Gadd34HP20979/CyO-Df(2R)B80, y+
Harvard	- PBac{RB}Gadd34e02638
VDRC	v107545 P{KK104106}VIE-260B v15238 w1118; P{GD5953}v15238
Genomic Clones ( 1 )
	BACR28M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 52 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11727
Other clones	DPiM_GH11727
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02337 AT05735 HL01282 LD05038 LD15117 LD23349 LD43005 LD43283 LD44508 LD46677 RE06173 RE06670 RE23027 RE36461 RE37352 RE39093 RE42678 RE45632 RH55727 RH64118 SD09375 SD09745 SD19425 SD21557
Other clones	15785 69832 102986 125784 149527 194830 211208 214381.70 bs27a04 bs61e04 CK01.11A.B4 Dmel_neb_015023_0936_3315 EK224331 EK242753 EK248015 EK290919 EK303406 EN07104 EP11044 FGM102B09 RE41931 RP003087494 RP003161002 RP003251455 RP003288794 RP003573689
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034948 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37820
Antibody Information
Other Information
Discoverer
Etymology
	Named 'Gadd34' after its human ortholog. (Garrey et al., )
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gadd34 CG3825 (Garrey et al., )
Source for database merge of
Additional comments	FlyBase Curator comment: Queried author Kampinga who said "The drosophila GADD34 we mention in our JBC paper is CG3825". (Carra et al., 2010)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138019 RefSeq (Proteins) • NP_611863 DDBJ / EMBL / GenBank • AA440042 AAF47124 AAK92874 AI134303 AI520625 AI946490 AY051450 Entrez Gene - A searchable database of RefSeq genes. • 37820 UniProtKB/TrEMBL • Q9W1E4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein phosphatase 1, regulatory subunit 15A/B, C-terminal (IPR019523) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH11727
Linkouts
	BioGRID - A database of protein and genetic interactions • 63407 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034948 DroID - A comprehensive database of gene and protein interactions. • FBgn0034948 DRSC - Results from RNAi screens. • FBgn0034948 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034948 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3825-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034948 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37820 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37820 modMine - Data generated by the modENCODE project. • FBgn0034948
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG3825 (Zhou et al., 2008, Garrey et al., , Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Bennett et al., 2006, Japanese National Institute of Genetics, 2012.5.21) dGADD34 (Garrey et al., ) Dm-GADD34 (Carra et al., 2010) GADD34 (Carra et al., 2010, Garrey et al., ) Gadd34   gadd34 (Bennett et al., 2006)
Name Synonym
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 10 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...