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Gene Dmel\eIF-5A

General Information
Symbol	Dmel\eIF-5A	Species	D. melanogaster
Name	eIF-5A	Annotation symbol	CG3186
Feature type	protein_coding_gene	FlyBase ID	FBgn0034967
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(2)01296, eIF5a
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	60B7-60B7	Sequence location	2R:19,945,347..19,947,002 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene eIF-5A is referred to in FlyBase by the symbol Dmel\eIF-5A (CG3186, FBgn0034967). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation regulator activity. There is experimental evidence that it is involved in the biological process: wing disc development; autophagic cell death; multicellular organism reproduction; salivary gland cell autophagic cell death. 6 alleles are reported. The phenotypes of these alleles are annotated with: macrochaeta; embryonic/larval fat body; wing cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Nucleic acid-binding, OB-fold; Ribosomal protein L2 domain 2; Translation elongation factor IF5A; Translation elongation factor, IF5A C-terminal; Translation elongation factor, IF5A, hypusine site; Translation protein SH3-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638349_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of eIF-5A. Gene sequence location is 2R:19945347..19947002.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B7-60B7   Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60B-60B     (Irion, 1999.9.16) 60B4-60B5   (determined by in situ hybridisation)   (Spradling et al., 1999) 60B4-60B5     (Beaton, 1997.12.27) 60B4-60B5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Posey, 1999.6.15)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF-5A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF-5A-RA FBtr0072173  NM_138034   777   159 eIF-5A-RB FBtr0072172  NM_166654   773   159
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF-5A-PA   FBpp0072082   17.6   159   4.76     NP_611878   AAF47151 eIF-5A-PB   FBpp0072081   17.6   159   4.76     NP_726411   AAM68297
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Translation elongation factor IF5A (IPR001884) Translation protein SH3-like domain (IPR008991) Nucleic acid-binding, OB-fold (IPR012340) Ribosomal protein L2 domain 2 (IPR014722) Translation elongation factor, IF5A, hypusine site (IPR019769) Translation elongation factor, IF5A C-terminal (IPR020189)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141545   AA263945   AA390982   AA391444   AA433269   AA696439   AA736005   AA801677   AA802975   AA803580   AA820080   AA941453   AA941886   AA941929   AA942421   AA949705   AA950496   AA978463   AA978510   AA979234   AE013599 AAF47151   AE013599 AAM68297   AF159443 AAF80375   AF187730 AAG17032   AI063660   AI106678   AI106907   AI108365   AI113383   AI135193   AI259351   AI259741   AI260724   AI293091   AI295005   AI296864   AI297558   AI403879   AI406102   AI455248   AI511785   AI512856   AI514281   AI517293   AI517576   AI520299   AI531379   AI532770   AI533271   AI946248   AY071396 AAL49018   AY231769   AY232071   BG636583   BG637336   BG637398   BG640198   BG640293   BG640498   BG640725   BG641195   BI163186   BI163535   BI163982   BI163995   BI164128   BI164445   BI165312   BI165443   BI165699   BI166306   BI168420   BI168464   BI169715   BI169810   BI169943   BI170066   BI171082   BI171689   BI171921   BI172192   BI173121   BI173147   BI212855   BI213043   BI213431   BI213532   BI213782   BI214052   BI214059   BI214604   BI216171   BI216501   BI216759   BI227666   BI228047   BI229046   BI229087   BI229222   BI230209   BI230259   BI230353   BI231068   BI231408   BI232259   BI232596   BI234158   BI234688   BI236062   BI237323   BI237786   BI238706   BI239053   BI239755   BI239817   BI240512   BI240609   BI241929   BI242144   BI242437   BI242549   BI243060   BI243496   BI243525   BI243528   BI243716   BI351890   BI351919   BI352036   BI352128   BI352134   BI353085   BI353172   BI353589   BI353679   BI354620   BI354630   BI354941   BI355047   BI355355   BI355667   BI355929   BI356388   BI357114   BI358564   BI362428   BI362963   BI362996   BI363002   BI363053   BI363955   BI363969   BI363986   BI365511   BI365527   BI365541   BI365712   BI366083   BI366298   BI366633   BI366809   BI367754   BI368346   BI368822   BI368873   BI369124   BI372576   BI373132   BI373336   BI373639   BI373876   BI374359   BI374418   BI374569   BI375416   BI375417   BI481684   BI483170   BI483786   BI485794   BI485883   BI565015   BI565213   BI565341   BI566048   BI566312   BI569682   BI572232   BI572588   BI572591   BI572767   BI574188   BI575294   BI575295   BI575302   BI577501   BI578270   BI578747   BI579769   BI581032   BI583651   BI584670   BI586124   BI586905   BI586910   BI588679   BI591450   BI591508   BI591687   BI591761   BI591867   BI592843   BI604640   BI604959   BI605134   BI606575   BI606683   BI606800   BI607385   BI610221   BI610409   BI610633   BI611623   BI612379   BI612468   BI615101   BI615117   BI615472   BI617451   BI617825   BI618303   BI619608   BI620549   BI620874   BI622460   BI623127   BI625074   BI629481   BI629548   BI630316   BI630762   BI632204   BI632394   BI632817   BI633658   BI634648   BI634827   BI635518   BI636034   BI636137   BI636989   BI637209   BI637437   BI637711   BI638390   BI638425   BI639935   BI641253   BI641491   BI641617   BI641620   BI641652   BP540431   BP540794   BP541323   BP541541   BP541628   BP541709   BP541836   BP541940   BP542348   BP542410   BP542485   BP542527   BP542954   BP543174   BP543266   BP543485   BP543951   BP544108   BP544334   BP544568   BP544853   BP544863   BP545198   BP545339   BP545423   BP545703   BP545711   BP545848   BP545888   BP545920   BP545955   BP546172   BP546433   BP546529   BP546790   BP547025   BP547205   BP547630   BP547967   BP548113   BP548318   BP548528   BP549077   BP549743   BP550596   BP550934   BP551105   BP551639   BP551936   BP552208   BP552238   BP552717   BP552721   BP552892   BP553035   BP554006   BP554036   BP554675   BP555008   BP556357   BP556462   BP556463   BP556718   BP557026   BP557040   BP557762   BP557763   BP558400   BP558697   BP560191   BP560419   BP560421   BQ103214   BQ103220   BQ103627   CA805597   CK657142   CK658959   CK660205   CK661031   CO153680   CO155053   CO156416   CO156481   CO157083   CO179757   CO179810   CO181917   CO182618   CO182783   CO183488   CO183650   CO184019   CO184084   CO185144   CO190658   CO190970   CO191306   CO191635   CO192812   CO192829   CO193459   CO195409   CO195503   CO262553   CO265339   CO267698   CO278359   CO280313   CO282747   CO291401   CO295720   CO300852   CO304432   CO308019   CO318031   CO319177   CO320724   CO323973   CO335571   CO335768   CO336863   CO341379   EC060000   EC069588   EC074739   EC075512   EC084253   EC084479   EC086208   EC194695   EC199629   EC200263   EC202428   EC202788   EC205474   EC207910   EC226532   EC227109   EC233696   EC233830   EC237287   EC239006   EC242365   EC244465   EC253467   EC261823   EC265008   EC265795   EC265804   EC265869   EC265908   EL871642   EL871767   EL871894   ES689898   ES689899   ES689903   ES689923   ES689925   ES689929   EV575481   EV575924   EV576018   EV577101   EV577320   EV579269   EV582676   EV582792   EV584869   EV585267   EV586228   EV586363   EV586445   EV586780   EV587673   EV587703   EV588174   EV588681   EV588930   EV589619   EV589626   EV589796   EV590074   EV590199   EV590461   EV590554   EV590955   EV591746   EV591844   EV592917   EV593486   EV593603   EV593606   EV593961   EV594070   EV594565   EV594987   EV595188   EV595371   EV595439   EV595708   EV595837   EV596834   EV597139   EV598756   EV599815   EV600175   EV600203   G00596
UniProtKB/Swiss-Prot	Q9GU68
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2704.9 Larval Midgut    4077.8 Larval Hindgut    4211.7 Larval Malpighian Tubules    4984.4 Larval Fat Body    6895.4 Larval Salivary Gland    7920.6 Larval Trachea    4917.825 Larval Carcass    4294.175 Adult Head    3413.8 Adult Eye    4426.65 Adult Brain    1591.4 Adult Thoracic-Abdominal Ganglion    2109.4 Adult Crop    5010.6 Adult Midgut    3774.8 Adult Hindgut    3816.4 Adult Malpighian Tubules    4956.2 Adult Fat Body    5368.8 Adult Salivary Gland    8761.9 Adult Heart    5552.05 Adult VirginFemale Spermatheca    4731 Adult InseminatedFemale Spermatheca    4837.6 Adult Ovary    3140.9 Adult Testis    1676.8 Adult Male Accessory Gland    7318.3 Adult Carcass    4700.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2704.9) Larval Midgut  (4077.8) Larval Hindgut  (4211.7) Larval Malpighian Tubules  (4984.4) Larval Fat Body  (6895.4) Larval Salivary Gland  (7920.6) Larval Trachea  (4917.825) Larval Carcass  (4294.175) Adult Head  (3413.8) Adult Eye  (4426.65) Adult Brain  (1591.4) Adult Thoracic-Abdominal Ganglion  (2109.4) Adult Crop  (5010.6) Adult Midgut  (3774.8) Adult Hindgut  (3816.4) Adult Malpighian Tubules  (4956.2) Adult Fat Body  (5368.8) Adult Salivary Gland  (8761.9) Adult Heart  (5552.05) Adult VirginFemale Spermatheca  (4731) Adult InseminatedFemale Spermatheca  (4837.6) Adult Ovary  (3140.9) Adult Testis  (1676.8) Adult Male Accessory Gland  (7318.3) Adult Carcass  (4700.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2704.9) Larval Midgut  (4077.8) Larval Hindgut  (4211.7) Larval Malpighian Tubules  (4984.4) Larval Fat Body  (6895.4) Larval Salivary Gland  (7920.6) Larval Trachea  (4917.825) Larval Carcass  (4294.175) Adult Head  (3413.8) Adult Eye  (4426.65) Adult Brain  (1591.4) Adult Thoracic-Abdominal Ganglion  (2109.4) Adult Crop  (5010.6) Adult Midgut  (3774.8) Adult Hindgut  (3816.4) Adult Malpighian Tubules  (4956.2) Adult Fat Body  (5368.8) Adult Salivary Gland  (8761.9) Adult Heart  (5552.05) Adult VirginFemale Spermatheca  (4731) Adult InseminatedFemale Spermatheca  (4837.6) Adult Ovary  (3140.9) Adult Testis  (1676.8) Adult Male Accessory Gland  (7318.3) Adult Carcass  (4700.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2704.9 Larval Midgut    4077.8 Larval Hindgut    4211.7 Larval Malpighian Tubules    4984.4 Larval Fat Body    6895.4 Larval Salivary Gland    7920.6 Larval Trachea    4917.825 Larval Carcass    4294.175 Adult Head    3413.8 Adult Eye    4426.65 Adult Brain    1591.4 Adult Thoracic-Abdominal Ganglion    2109.4 Adult Crop    5010.6 Adult Midgut    3774.8 Adult Hindgut    3816.4 Adult Malpighian Tubules    4956.2 Adult Fat Body    5368.8 Adult Salivary Gland    8761.9 Adult Heart    5552.05 Adult VirginFemale Spermatheca    4731 Adult InseminatedFemale Spermatheca    4837.6 Adult Ovary    3140.9 Adult Testis    1676.8 Adult Male Accessory Gland    7318.3 Adult Carcass    4700.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2704.9 Larval Midgut    4077.8 Larval Hindgut    4211.7 Larval Malpighian Tubules    4984.4 Larval Fat Body    6895.4 Larval Salivary Gland    7920.6 Larval Trachea    4917.825 Larval Carcass    4294.175 Adult Head    3413.8 Adult Eye    4426.65 Adult Brain    1591.4 Adult Thoracic-Abdominal Ganglion    2109.4 Adult Crop    5010.6 Adult Midgut    3774.8 Adult Hindgut    3816.4 Adult Malpighian Tubules    4956.2 Adult Fat Body    5368.8 Adult Salivary Gland    8761.9 Adult Heart    5552.05 Adult VirginFemale Spermatheca    4731 Adult InseminatedFemale Spermatheca    4837.6 Adult Ovary    3140.9 Adult Testis    1676.8 Adult Male Accessory Gland    7318.3 Adult Carcass    4700.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2704.9) Larval Midgut  (4077.8) Larval Hindgut  (4211.7) Larval Malpighian Tubules  (4984.4) Larval Fat Body  (6895.4) Larval Salivary Gland  (7920.6) Larval Trachea  (4917.825) Larval Carcass  (4294.175) Adult Head  (3413.8) Adult Eye  (4426.65) Adult Brain  (1591.4) Adult Thoracic-Abdominal Ganglion  (2109.4) Adult Crop  (5010.6) Adult Midgut  (3774.8) Adult Hindgut  (3816.4) Adult Malpighian Tubules  (4956.2) Adult Fat Body  (5368.8) Adult Salivary Gland  (8761.9) Adult Heart  (5552.05) Adult VirginFemale Spermatheca  (4731) Adult InseminatedFemale Spermatheca  (4837.6) Adult Ovary  (3140.9) Adult Testis  (1676.8) Adult Male Accessory Gland  (7318.3) Adult Carcass  (4700.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2704.9) Larval Midgut  (4077.8) Larval Hindgut  (4211.7) Larval Malpighian Tubules  (4984.4) Larval Fat Body  (6895.4) Larval Salivary Gland  (7920.6) Larval Trachea  (4917.825) Larval Carcass  (4294.175) Adult Head  (3413.8) Adult Eye  (4426.65) Adult Brain  1591.4 Adult Thoracic-Abdominal Ganglion  (2109.4) Adult Crop  (5010.6) Adult Midgut  (3774.8) Adult Hindgut  (3816.4) Adult Malpighian Tubules  (4956.2) Adult Fat Body  (5368.8) Adult Salivary Gland  (8761.9) Adult Heart  (5552.05) Adult VirginFemale Spermatheca  (4731) Adult InseminatedFemale Spermatheca  (4837.6) Adult Ovary  (3140.9) Adult Testis  1676.8 Adult Male Accessory Gland  (7318.3) Adult Carcass  (4700.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2704.9 Larval Midgut    4077.8 Larval Hindgut    4211.7 Larval Malpighian Tubules    4984.4 Larval Fat Body    6895.4 Larval Salivary Gland    7920.6 Larval Trachea    4917.825 Larval Carcass    4294.175 Adult Head    3413.8 Adult Eye    4426.65 Adult Brain    1591.4 Adult Thoracic-Abdominal Ganglion    2109.4 Adult Crop    5010.6 Adult Midgut    3774.8 Adult Hindgut    3816.4 Adult Malpighian Tubules    4956.2 Adult Fat Body    5368.8 Adult Salivary Gland    8761.9 Adult Heart    5552.05 Adult VirginFemale Spermatheca    4731 Adult InseminatedFemale Spermatheca    4837.6 Adult Ovary    3140.9 Adult Testis    1676.8 Adult Male Accessory Gland    7318.3 Adult Carcass    4700.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3413.8   NA  Eye    4426.65   NA  Brain    1591.4   2704.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2109.4   NA  Crop    5010.6   4077.8  Midgut    3774.8   4211.7  Hindgut    3816.4   4984.4  Malpighian Tubules    4956.2   6895.4  Fat Body    5368.8   7920.6  Salivary Gland    8761.9   NA  Heart    5552.05   4917.825  Trachea    NA   NA  VirginFemale Spermatheca    4731   NA  InseminatedFemale Spermatheca    4837.6   NA  Ovary    3140.9   NA  Testis    1676.8   NA  Male Accessory Gland    7318.3   4294.175  Carcass    4700.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    737 central nervous system, larvae L3    739 central nervous system, pupae P8    497 head, virgin 1-day female    494 head, virgin 4-day female    537 head, virgin 20-day female    613 head, mated 1-day female    438 head, mated 4-day female    620 head, mated 20-day female    510 head, mated 1-day male    362 head, mated 4-day male    422 head, mated 20-day male    668 salivary gland, larvae L3 wandering    1278 salivary gland, white prepupae    2525 digestive system, larvae L3 wandering    847 digestive system, 1-day adult    730 digestive system, 4-day adult    601 digestive system, 20-day adult    511 fat body, larvae L3 wandering    523 fat body, white prepupae    748 fat body, pupae P8    1293 carcass, larvae L3 wandering    957 carcass, 1-day adult    428 carcass, 4-day adult    564 carcass, 20-day adult    475 ovary, virgin 4-day female    1377 ovary, mated 4-day female    1150 testis, mated 4-day male    395 accessory gland, mated 4-day male    514 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (737) central nervous system, larvae L3  (739) central nervous system, pupae P8  (497) head, virgin 1-day female  (494) head, virgin 4-day female  (537) head, virgin 20-day female  (613) head, mated 1-day female  (438) head, mated 4-day female  (620) head, mated 20-day female  (510) head, mated 1-day male  (362) head, mated 4-day male  (422) head, mated 20-day male  (668) salivary gland, larvae L3 wandering  (1278) salivary gland, white prepupae  (2525) digestive system, larvae L3 wandering  (847) digestive system, 1-day adult  (730) digestive system, 4-day adult  (601) digestive system, 20-day adult  (511) fat body, larvae L3 wandering  (523) fat body, white prepupae  (748) fat body, pupae P8  (1293) carcass, larvae L3 wandering  (957) carcass, 1-day adult  (428) carcass, 4-day adult  (564) carcass, 20-day adult  (475) ovary, virgin 4-day female  (1377) ovary, mated 4-day female  (1150) testis, mated 4-day male  (395) accessory gland, mated 4-day male  (514) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (737) central nervous system, larvae L3  (739) central nervous system, pupae P8  (497) head, virgin 1-day female  (494) head, virgin 4-day female  (537) head, virgin 20-day female  (613) head, mated 1-day female  (438) head, mated 4-day female  (620) head, mated 20-day female  (510) head, mated 1-day male  (362) head, mated 4-day male  (422) head, mated 20-day male  (668) salivary gland, larvae L3 wandering  (1278) salivary gland, white prepupae  (2525) digestive system, larvae L3 wandering  (847) digestive system, 1-day adult  (730) digestive system, 4-day adult  (601) digestive system, 20-day adult  (511) fat body, larvae L3 wandering  (523) fat body, white prepupae  (748) fat body, pupae P8  (1293) carcass, larvae L3 wandering  (957) carcass, 1-day adult  (428) carcass, 4-day adult  (564) carcass, 20-day adult  (475) ovary, virgin 4-day female  (1377) ovary, mated 4-day female  (1150) testis, mated 4-day male  (395) accessory gland, mated 4-day male  (514) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    737 central nervous system, larvae L3    739 central nervous system, pupae P8    497 head, virgin 1-day female    494 head, virgin 4-day female    537 head, virgin 20-day female    613 head, mated 1-day female    438 head, mated 4-day female    620 head, mated 20-day female    510 head, mated 1-day male    362 head, mated 4-day male    422 head, mated 20-day male    668 salivary gland, larvae L3 wandering    1278 salivary gland, white prepupae    2525 digestive system, larvae L3 wandering    847 digestive system, 1-day adult    730 digestive system, 4-day adult    601 digestive system, 20-day adult    511 fat body, larvae L3 wandering    523 fat body, white prepupae    748 fat body, pupae P8    1293 carcass, larvae L3 wandering    957 carcass, 1-day adult    428 carcass, 4-day adult    564 carcass, 20-day adult    475 ovary, virgin 4-day female    1377 ovary, mated 4-day female    1150 testis, mated 4-day male    395 accessory gland, mated 4-day male    514 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    737 central nervous system, larvae L3    739 central nervous system, pupae P8    497 head, virgin 1-day female    494 head, virgin 4-day female    537 head, virgin 20-day female    613 head, mated 1-day female    438 head, mated 4-day female    620 head, mated 20-day female    510 head, mated 1-day male    362 head, mated 4-day male    422 head, mated 20-day male    668 salivary gland, larvae L3 wandering    1278 salivary gland, white prepupae    2525 digestive system, larvae L3 wandering    847 digestive system, 1-day adult    730 digestive system, 4-day adult    601 digestive system, 20-day adult    511 fat body, larvae L3 wandering    523 fat body, white prepupae    748 fat body, pupae P8    1293 carcass, larvae L3 wandering    957 carcass, 1-day adult    428 carcass, 4-day adult    564 carcass, 20-day adult    475 ovary, virgin 4-day female    1377 ovary, mated 4-day female    1150 testis, mated 4-day male    395 accessory gland, mated 4-day male    514 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (737) central nervous system, larvae L3  (739) central nervous system, pupae P8  (497) head, virgin 1-day female  (494) head, virgin 4-day female  (537) head, virgin 20-day female  (613) head, mated 1-day female  (438) head, mated 4-day female  (620) head, mated 20-day female  (510) head, mated 1-day male  (362) head, mated 4-day male  (422) head, mated 20-day male  (668) salivary gland, larvae L3 wandering  (1278) salivary gland, white prepupae  (2525) digestive system, larvae L3 wandering  (847) digestive system, 1-day adult  (730) digestive system, 4-day adult  (601) digestive system, 20-day adult  (511) fat body, larvae L3 wandering  (523) fat body, white prepupae  (748) fat body, pupae P8  (1293) carcass, larvae L3 wandering  (957) carcass, 1-day adult  (428) carcass, 4-day adult  (564) carcass, 20-day adult  (475) ovary, virgin 4-day female  (1377) ovary, mated 4-day female  (1150) testis, mated 4-day male  (395) accessory gland, mated 4-day male  (514) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (737) central nervous system, larvae L3  (739) central nervous system, pupae P8  (497) head, virgin 1-day female  (494) head, virgin 4-day female  (537) head, virgin 20-day female  (613) head, mated 1-day female  (438) head, mated 4-day female  (620) head, mated 20-day female  (510) head, mated 1-day male  (362) head, mated 4-day male  (422) head, mated 20-day male  (668) salivary gland, larvae L3 wandering  (1278) salivary gland, white prepupae  (2525) digestive system, larvae L3 wandering  (847) digestive system, 1-day adult  (730) digestive system, 4-day adult  (601) digestive system, 20-day adult  (511) fat body, larvae L3 wandering  (523) fat body, white prepupae  (748) fat body, pupae P8  (1293) carcass, larvae L3 wandering  (957) carcass, 1-day adult  (428) carcass, 4-day adult  (564) carcass, 20-day adult  (475) ovary, virgin 4-day female  (1377) ovary, mated 4-day female  (1150) testis, mated 4-day male  (395) accessory gland, mated 4-day male  (514) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    737 central nervous system, larvae L3    739 central nervous system, pupae P8    497 head, virgin 1-day female    494 head, virgin 4-day female    537 head, virgin 20-day female    613 head, mated 1-day female    438 head, mated 4-day female    620 head, mated 20-day female    510 head, mated 1-day male    362 head, mated 4-day male    422 head, mated 20-day male    668 salivary gland, larvae L3 wandering    1278 salivary gland, white prepupae    2525 digestive system, larvae L3 wandering    847 digestive system, 1-day adult    730 digestive system, 4-day adult    601 digestive system, 20-day adult    511 fat body, larvae L3 wandering    523 fat body, white prepupae    748 fat body, pupae P8    1293 carcass, larvae L3 wandering    957 carcass, 1-day adult    428 carcass, 4-day adult    564 carcass, 20-day adult    475 ovary, virgin 4-day female    1377 ovary, mated 4-day female    1150 testis, mated 4-day male    395 accessory gland, mated 4-day male    514 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1099 embryo 02-04hr    2241 embryo 04-06hr    2929 embryo 06-08hr    2116 embryo 08-10hr    2401 embryo 10-12hr    1951 embryo 12-14hr    2474 embryo 14-16hr    1061 embryo 16-18hr    1265 embryo 18-20hr    996 embryo 20-22hr    1411 embryo 22-24hr    1715 larva L1    1193 larva L2    1589 larva L3 12hr old    1059 larva L3 puffstage 1-2    1290 larva L3 puffstage 3-6    1278 larva L3 puffstage 7-9    1794 white prepupae new    1718 white prepupae 12hr    1648 white prepupae 24hr    1708 pupae 2d postWPP    1407 pupae 3d postWPP    873 pupae 4d postWPP    485 adult male 01day    565 adult male 05day    404 adult male 30day    379 adult female 01day    860 adult female 05day    1497 adult female 30day    1182 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1099) embryo 02-04hr  (2241) embryo 04-06hr  (2929) embryo 06-08hr  (2116) embryo 08-10hr  (2401) embryo 10-12hr  (1951) embryo 12-14hr  (2474) embryo 14-16hr  (1061) embryo 16-18hr  (1265) embryo 18-20hr  (996) embryo 20-22hr  (1411) embryo 22-24hr  (1715) larva L1  (1193) larva L2  (1589) larva L3 12hr old  (1059) larva L3 puffstage 1-2  (1290) larva L3 puffstage 3-6  (1278) larva L3 puffstage 7-9  (1794) white prepupae new  (1718) white prepupae 12hr  (1648) white prepupae 24hr  (1708) pupae 2d postWPP  (1407) pupae 3d postWPP  (873) pupae 4d postWPP  (485) adult male 01day  (565) adult male 05day  (404) adult male 30day  (379) adult female 01day  (860) adult female 05day  (1497) adult female 30day  (1182) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (1099) embryo 02-04hr  (2241) embryo 04-06hr  (2929) embryo 06-08hr  (2116) embryo 08-10hr  (2401) embryo 10-12hr  (1951) embryo 12-14hr  (2474) embryo 14-16hr  (1061) embryo 16-18hr  (1265) embryo 18-20hr  (996) embryo 20-22hr  (1411) embryo 22-24hr  (1715) larva L1  (1193) larva L2  (1589) larva L3 12hr old  (1059) larva L3 puffstage 1-2  (1290) larva L3 puffstage 3-6  (1278) larva L3 puffstage 7-9  (1794) white prepupae new  (1718) white prepupae 12hr  (1648) white prepupae 24hr  (1708) pupae 2d postWPP  (1407) pupae 3d postWPP  (873) pupae 4d postWPP  (485) adult male 01day  (565) adult male 05day  (404) adult male 30day  (379) adult female 01day  (860) adult female 05day  (1497) adult female 30day  (1182) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1099 embryo 02-04hr    2241 embryo 04-06hr    2929 embryo 06-08hr    2116 embryo 08-10hr    2401 embryo 10-12hr    1951 embryo 12-14hr    2474 embryo 14-16hr    1061 embryo 16-18hr    1265 embryo 18-20hr    996 embryo 20-22hr    1411 embryo 22-24hr    1715 larva L1    1193 larva L2    1589 larva L3 12hr old    1059 larva L3 puffstage 1-2    1290 larva L3 puffstage 3-6    1278 larva L3 puffstage 7-9    1794 white prepupae new    1718 white prepupae 12hr    1648 white prepupae 24hr    1708 pupae 2d postWPP    1407 pupae 3d postWPP    873 pupae 4d postWPP    485 adult male 01day    565 adult male 05day    404 adult male 30day    379 adult female 01day    860 adult female 05day    1497 adult female 30day    1182 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1099 embryo 02-04hr    2241 embryo 04-06hr    2929 embryo 06-08hr    2116 embryo 08-10hr    2401 embryo 10-12hr    1951 embryo 12-14hr    2474 embryo 14-16hr    1061 embryo 16-18hr    1265 embryo 18-20hr    996 embryo 20-22hr    1411 embryo 22-24hr    1715 larva L1    1193 larva L2    1589 larva L3 12hr old    1059 larva L3 puffstage 1-2    1290 larva L3 puffstage 3-6    1278 larva L3 puffstage 7-9    1794 white prepupae new    1718 white prepupae 12hr    1648 white prepupae 24hr    1708 pupae 2d postWPP    1407 pupae 3d postWPP    873 pupae 4d postWPP    485 adult male 01day    565 adult male 05day    404 adult male 30day    379 adult female 01day    860 adult female 05day    1497 adult female 30day    1182 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1099) embryo 02-04hr  (2241) embryo 04-06hr  (2929) embryo 06-08hr  (2116) embryo 08-10hr  (2401) embryo 10-12hr  (1951) embryo 12-14hr  (2474) embryo 14-16hr  (1061) embryo 16-18hr  (1265) embryo 18-20hr  (996) embryo 20-22hr  (1411) embryo 22-24hr  (1715) larva L1  (1193) larva L2  (1589) larva L3 12hr old  (1059) larva L3 puffstage 1-2  (1290) larva L3 puffstage 3-6  (1278) larva L3 puffstage 7-9  (1794) white prepupae new  (1718) white prepupae 12hr  (1648) white prepupae 24hr  (1708) pupae 2d postWPP  (1407) pupae 3d postWPP  (873) pupae 4d postWPP  (485) adult male 01day  (565) adult male 05day  (404) adult male 30day  (379) adult female 01day  (860) adult female 05day  (1497) adult female 30day  (1182) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (1099) embryo 02-04hr  (2241) embryo 04-06hr  (2929) embryo 06-08hr  (2116) embryo 08-10hr  (2401) embryo 10-12hr  (1951) embryo 12-14hr  (2474) embryo 14-16hr  (1061) embryo 16-18hr  (1265) embryo 18-20hr  (996) embryo 20-22hr  (1411) embryo 22-24hr  (1715) larva L1  (1193) larva L2  (1589) larva L3 12hr old  (1059) larva L3 puffstage 1-2  (1290) larva L3 puffstage 3-6  (1278) larva L3 puffstage 7-9  (1794) white prepupae new  (1718) white prepupae 12hr  (1648) white prepupae 24hr  (1708) pupae 2d postWPP  (1407) pupae 3d postWPP  (873) pupae 4d postWPP  (485) adult male 01day  (565) adult male 05day  (404) adult male 30day  (379) adult female 01day  (860) adult female 05day  (1497) adult female 30day  (1182) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1099 embryo 02-04hr    2241 embryo 04-06hr    2929 embryo 06-08hr    2116 embryo 08-10hr    2401 embryo 10-12hr    1951 embryo 12-14hr    2474 embryo 14-16hr    1061 embryo 16-18hr    1265 embryo 18-20hr    996 embryo 20-22hr    1411 embryo 22-24hr    1715 larva L1    1193 larva L2    1589 larva L3 12hr old    1059 larva L3 puffstage 1-2    1290 larva L3 puffstage 3-6    1278 larva L3 puffstage 7-9    1794 white prepupae new    1718 white prepupae 12hr    1648 white prepupae 24hr    1708 pupae 2d postWPP    1407 pupae 3d postWPP    873 pupae 4d postWPP    485 adult male 01day    565 adult male 05day    404 adult male 30day    379 adult female 01day    860 adult female 05day    1497 adult female 30day    1182 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2359 Schneider line 2 Sg4    1107 embryonic 1182-4H    1074 embryonic GM2    1065 embryonic Kc167    1392 embryonic S1    1072 embryonic S3    1362 leg disc CME L1    1188 wing disc CME-W2    1776 wing disc ML-DmD8    1018 wing disc ML-DmD9    1004 wing disc ML-DmD16-c3    921 wing disc ML-DmD21    1816 wing disc ML-DmD32    596 haltere disc ML-DmD17-c3    1668 eye-antennal disc ML-DmD11    1105 antennal disc ML-DmD20-c5    1395 mixed discs ML-DmD4-c1    1079 CNS ML-DmBG1-c1    1081 CNS ML-DmBG2-c2    1579 tumorous blood cells mbn2    1044 ovary fGS/OSS    1579 ovary OSC    1408 ovary OSS    1351 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (2359) Schneider line 2 Sg4  (1107) embryonic 1182-4H  (1074) embryonic GM2  (1065) embryonic Kc167  (1392) embryonic S1  (1072) embryonic S3  (1362) leg disc CME L1  (1188) wing disc CME-W2  (1776) wing disc ML-DmD8  (1018) wing disc ML-DmD9  (1004) wing disc ML-DmD16-c3  (921) wing disc ML-DmD21  (1816) wing disc ML-DmD32  (596) haltere disc ML-DmD17-c3  (1668) eye-antennal disc ML-DmD11  (1105) antennal disc ML-DmD20-c5  (1395) mixed discs ML-DmD4-c1  (1079) CNS ML-DmBG1-c1  (1081) CNS ML-DmBG2-c2  (1579) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (1579) ovary OSC  (1408) ovary OSS  (1351) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (2359) Schneider line 2 Sg4  (1107) embryonic 1182-4H  (1074) embryonic GM2  (1065) embryonic Kc167  (1392) embryonic S1  (1072) embryonic S3  (1362) leg disc CME L1  (1188) wing disc CME-W2  (1776) wing disc ML-DmD8  (1018) wing disc ML-DmD9  (1004) wing disc ML-DmD16-c3  (921) wing disc ML-DmD21  (1816) wing disc ML-DmD32  (596) haltere disc ML-DmD17-c3  (1668) eye-antennal disc ML-DmD11  (1105) antennal disc ML-DmD20-c5  (1395) mixed discs ML-DmD4-c1  (1079) CNS ML-DmBG1-c1  (1081) CNS ML-DmBG2-c2  (1579) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (1579) ovary OSC  (1408) ovary OSS  (1351) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2359 Schneider line 2 Sg4    1107 embryonic 1182-4H    1074 embryonic GM2    1065 embryonic Kc167    1392 embryonic S1    1072 embryonic S3    1362 leg disc CME L1    1188 wing disc CME-W2    1776 wing disc ML-DmD8    1018 wing disc ML-DmD9    1004 wing disc ML-DmD16-c3    921 wing disc ML-DmD21    1816 wing disc ML-DmD32    596 haltere disc ML-DmD17-c3    1668 eye-antennal disc ML-DmD11    1105 antennal disc ML-DmD20-c5    1395 mixed discs ML-DmD4-c1    1079 CNS ML-DmBG1-c1    1081 CNS ML-DmBG2-c2    1579 tumorous blood cells mbn2    1044 ovary fGS/OSS    1579 ovary OSC    1408 ovary OSS    1351 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    2359 Schneider line 2 Sg4    1107 embryonic 1182-4H    1074 embryonic GM2    1065 embryonic Kc167    1392 embryonic S1    1072 embryonic S3    1362 leg disc CME L1    1188 wing disc CME-W2    1776 wing disc ML-DmD8    1018 wing disc ML-DmD9    1004 wing disc ML-DmD16-c3    921 wing disc ML-DmD21    1816 wing disc ML-DmD32    596 haltere disc ML-DmD17-c3    1668 eye-antennal disc ML-DmD11    1105 antennal disc ML-DmD20-c5    1395 mixed discs ML-DmD4-c1    1079 CNS ML-DmBG1-c1    1081 CNS ML-DmBG2-c2    1579 tumorous blood cells mbn2    1044 ovary fGS/OSS    1579 ovary OSC    1408 ovary OSS    1351 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (2359) Schneider line 2 Sg4  (1107) embryonic 1182-4H  (1074) embryonic GM2  (1065) embryonic Kc167  (1392) embryonic S1  (1072) embryonic S3  (1362) leg disc CME L1  (1188) wing disc CME-W2  (1776) wing disc ML-DmD8  (1018) wing disc ML-DmD9  (1004) wing disc ML-DmD16-c3  (921) wing disc ML-DmD21  (1816) wing disc ML-DmD32  (596) haltere disc ML-DmD17-c3  (1668) eye-antennal disc ML-DmD11  (1105) antennal disc ML-DmD20-c5  (1395) mixed discs ML-DmD4-c1  (1079) CNS ML-DmBG1-c1  (1081) CNS ML-DmBG2-c2  (1579) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (1579) ovary OSC  (1408) ovary OSS  (1351) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (2359) Schneider line 2 Sg4  (1107) embryonic 1182-4H  (1074) embryonic GM2  (1065) embryonic Kc167  (1392) embryonic S1  (1072) embryonic S3  (1362) leg disc CME L1  (1188) wing disc CME-W2  (1776) wing disc ML-DmD8  (1018) wing disc ML-DmD9  (1004) wing disc ML-DmD16-c3  (921) wing disc ML-DmD21  (1816) wing disc ML-DmD32  (596) haltere disc ML-DmD17-c3  (1668) eye-antennal disc ML-DmD11  (1105) antennal disc ML-DmD20-c5  (1395) mixed discs ML-DmD4-c1  (1079) CNS ML-DmBG1-c1  (1081) CNS ML-DmBG2-c2  (1579) tumorous blood cells mbn2  (1044) ovary fGS/OSS  (1579) ovary OSC  (1408) ovary OSS  (1351) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    2359 Schneider line 2 Sg4    1107 embryonic 1182-4H    1074 embryonic GM2    1065 embryonic Kc167    1392 embryonic S1    1072 embryonic S3    1362 leg disc CME L1    1188 wing disc CME-W2    1776 wing disc ML-DmD8    1018 wing disc ML-DmD9    1004 wing disc ML-DmD16-c3    921 wing disc ML-DmD21    1816 wing disc ML-DmD32    596 haltere disc ML-DmD17-c3    1668 eye-antennal disc ML-DmD11    1105 antennal disc ML-DmD20-c5    1395 mixed discs ML-DmD4-c1    1079 CNS ML-DmBG1-c1    1081 CNS ML-DmBG2-c2    1579 tumorous blood cells mbn2    1044 ovary fGS/OSS    1579 ovary OSC    1408 ovary OSS    1351 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    781 cold shock, 4-day adult    768 heat shock, 4-day adult    1030 Cadmium 50 mM 6 hrs, larvae L3    970 Cadmium 50 mM 12 hrs, larvae L3    1556 Cadmium 50 mM 48 hrs, 4-day adult    906 Cadmium 100 mM 48 hrs, 4-day adult    882 Copper 0.5 mM 12 hrs, larvae L3    1145 Copper 15 mM 48 hrs, 4-day adult    796 Zinc 5 mM 12 hrs, larvae L3    870 Zinc 4.5 mM 48 hrs, 4-day adult    752 Ethanol 2.5% 3 hrs, larvae L3    974 Ethanol 5% 3 hrs, larvae L3    1365 Ethanol 10% 3 hrs, larvae L3    931 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1244 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    999 Caffeine 25 mg/ml 48 hrs, 4-day adult    729 Paraquat 5 mM 48 hrs, 4-day adult    1004 Paraquat 10 mM 48 hrs, 4-day adult    879 Rotenone 2 μg 12 hrs, larvae L3    1237 Rotenone 8 μg 12 hrs, larvae L3    911 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (781) cold shock, 4-day adult  (768) heat shock, 4-day adult  (1030) Cadmium 50 mM 6 hrs, larvae L3  (970) Cadmium 50 mM 12 hrs, larvae L3  (1556) Cadmium 50 mM 48 hrs, 4-day adult  (906) Cadmium 100 mM 48 hrs, 4-day adult  (882) Copper 0.5 mM 12 hrs, larvae L3  (1145) Copper 15 mM 48 hrs, 4-day adult  (796) Zinc 5 mM 12 hrs, larvae L3  (870) Zinc 4.5 mM 48 hrs, 4-day adult  (752) Ethanol 2.5% 3 hrs, larvae L3  (974) Ethanol 5% 3 hrs, larvae L3  (1365) Ethanol 10% 3 hrs, larvae L3  (931) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1244) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (999) Caffeine 25 mg/ml 48 hrs, 4-day adult  (729) Paraquat 5 mM 48 hrs, 4-day adult  (1004) Paraquat 10 mM 48 hrs, 4-day adult  (879) Rotenone 2 μg 12 hrs, larvae L3  (1237) Rotenone 8 μg 12 hrs, larvae L3  (911) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (781) cold shock, 4-day adult  (768) heat shock, 4-day adult  (1030) Cadmium 50 mM 6 hrs, larvae L3  (970) Cadmium 50 mM 12 hrs, larvae L3  (1556) Cadmium 50 mM 48 hrs, 4-day adult  (906) Cadmium 100 mM 48 hrs, 4-day adult  (882) Copper 0.5 mM 12 hrs, larvae L3  (1145) Copper 15 mM 48 hrs, 4-day adult  (796) Zinc 5 mM 12 hrs, larvae L3  (870) Zinc 4.5 mM 48 hrs, 4-day adult  (752) Ethanol 2.5% 3 hrs, larvae L3  (974) Ethanol 5% 3 hrs, larvae L3  (1365) Ethanol 10% 3 hrs, larvae L3  (931) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1244) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (999) Caffeine 25 mg/ml 48 hrs, 4-day adult  (729) Paraquat 5 mM 48 hrs, 4-day adult  (1004) Paraquat 10 mM 48 hrs, 4-day adult  (879) Rotenone 2 μg 12 hrs, larvae L3  (1237) Rotenone 8 μg 12 hrs, larvae L3  (911) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    781 cold shock, 4-day adult    768 heat shock, 4-day adult    1030 Cadmium 50 mM 6 hrs, larvae L3    970 Cadmium 50 mM 12 hrs, larvae L3    1556 Cadmium 50 mM 48 hrs, 4-day adult    906 Cadmium 100 mM 48 hrs, 4-day adult    882 Copper 0.5 mM 12 hrs, larvae L3    1145 Copper 15 mM 48 hrs, 4-day adult    796 Zinc 5 mM 12 hrs, larvae L3    870 Zinc 4.5 mM 48 hrs, 4-day adult    752 Ethanol 2.5% 3 hrs, larvae L3    974 Ethanol 5% 3 hrs, larvae L3    1365 Ethanol 10% 3 hrs, larvae L3    931 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1244 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    999 Caffeine 25 mg/ml 48 hrs, 4-day adult    729 Paraquat 5 mM 48 hrs, 4-day adult    1004 Paraquat 10 mM 48 hrs, 4-day adult    879 Rotenone 2 μg 12 hrs, larvae L3    1237 Rotenone 8 μg 12 hrs, larvae L3    911 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    781 cold shock, 4-day adult    768 heat shock, 4-day adult    1030 Cadmium 50 mM 6 hrs, larvae L3    970 Cadmium 50 mM 12 hrs, larvae L3    1556 Cadmium 50 mM 48 hrs, 4-day adult    906 Cadmium 100 mM 48 hrs, 4-day adult    882 Copper 0.5 mM 12 hrs, larvae L3    1145 Copper 15 mM 48 hrs, 4-day adult    796 Zinc 5 mM 12 hrs, larvae L3    870 Zinc 4.5 mM 48 hrs, 4-day adult    752 Ethanol 2.5% 3 hrs, larvae L3    974 Ethanol 5% 3 hrs, larvae L3    1365 Ethanol 10% 3 hrs, larvae L3    931 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1244 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    999 Caffeine 25 mg/ml 48 hrs, 4-day adult    729 Paraquat 5 mM 48 hrs, 4-day adult    1004 Paraquat 10 mM 48 hrs, 4-day adult    879 Rotenone 2 μg 12 hrs, larvae L3    1237 Rotenone 8 μg 12 hrs, larvae L3    911 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (781) cold shock, 4-day adult  (768) heat shock, 4-day adult  (1030) Cadmium 50 mM 6 hrs, larvae L3  (970) Cadmium 50 mM 12 hrs, larvae L3  (1556) Cadmium 50 mM 48 hrs, 4-day adult  (906) Cadmium 100 mM 48 hrs, 4-day adult  (882) Copper 0.5 mM 12 hrs, larvae L3  (1145) Copper 15 mM 48 hrs, 4-day adult  (796) Zinc 5 mM 12 hrs, larvae L3  (870) Zinc 4.5 mM 48 hrs, 4-day adult  (752) Ethanol 2.5% 3 hrs, larvae L3  (974) Ethanol 5% 3 hrs, larvae L3  (1365) Ethanol 10% 3 hrs, larvae L3  (931) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1244) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (999) Caffeine 25 mg/ml 48 hrs, 4-day adult  (729) Paraquat 5 mM 48 hrs, 4-day adult  (1004) Paraquat 10 mM 48 hrs, 4-day adult  (879) Rotenone 2 μg 12 hrs, larvae L3  (1237) Rotenone 8 μg 12 hrs, larvae L3  (911) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (781) cold shock, 4-day adult  (768) heat shock, 4-day adult  (1030) Cadmium 50 mM 6 hrs, larvae L3  (970) Cadmium 50 mM 12 hrs, larvae L3  (1556) Cadmium 50 mM 48 hrs, 4-day adult  (906) Cadmium 100 mM 48 hrs, 4-day adult  (882) Copper 0.5 mM 12 hrs, larvae L3  (1145) Copper 15 mM 48 hrs, 4-day adult  (796) Zinc 5 mM 12 hrs, larvae L3  (870) Zinc 4.5 mM 48 hrs, 4-day adult  (752) Ethanol 2.5% 3 hrs, larvae L3  (974) Ethanol 5% 3 hrs, larvae L3  (1365) Ethanol 10% 3 hrs, larvae L3  (931) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (1244) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (999) Caffeine 25 mg/ml 48 hrs, 4-day adult  (729) Paraquat 5 mM 48 hrs, 4-day adult  (1004) Paraquat 10 mM 48 hrs, 4-day adult  (879) Rotenone 2 μg 12 hrs, larvae L3  (1237) Rotenone 8 μg 12 hrs, larvae L3  (911) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    781 cold shock, 4-day adult    768 heat shock, 4-day adult    1030 Cadmium 50 mM 6 hrs, larvae L3    970 Cadmium 50 mM 12 hrs, larvae L3    1556 Cadmium 50 mM 48 hrs, 4-day adult    906 Cadmium 100 mM 48 hrs, 4-day adult    882 Copper 0.5 mM 12 hrs, larvae L3    1145 Copper 15 mM 48 hrs, 4-day adult    796 Zinc 5 mM 12 hrs, larvae L3    870 Zinc 4.5 mM 48 hrs, 4-day adult    752 Ethanol 2.5% 3 hrs, larvae L3    974 Ethanol 5% 3 hrs, larvae L3    1365 Ethanol 10% 3 hrs, larvae L3    931 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1244 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    999 Caffeine 25 mg/ml 48 hrs, 4-day adult    729 Paraquat 5 mM 48 hrs, 4-day adult    1004 Paraquat 10 mM 48 hrs, 4-day adult    879 Rotenone 2 μg 12 hrs, larvae L3    1237 Rotenone 8 μg 12 hrs, larvae L3    911 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	BDGP expression data • RE47768 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034967 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3186-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive eIF-5A01296 eIF-5A10530 Other Phenotypes Allele decreased cell size eIF-5A01296 Phenotype manifest in Allele embryonic/larval fat body eIF-5A01296 macrochaeta, with Scer\GAL4Eq1 eIF-5AGD8700 wing cell, with Scer\GAL4dpp.blk1 eIF-5AGD8700
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of eIF-5A Class Mutagen Stocks Known lesion eIF-5A01296 P-element activity 1 Yes eIF-5A10530 P-element activity 0 -- eIF-5ABA00155 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF-5A Class Mutagen Stocks Known lesion eIF-5AScer\UAS.cPa in vitro construct - regulatory fusion 2 Yes eIF-5AGD8700 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-5AKK108942 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)bwVDe2LPxKR (Spradling et al., 1999, BDGP Project Members, 1994-1999, Beaton, 1997.12.27) Df(2R)bw-S46 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Chig230 (Bloomington Drosophila Stock Center, 1998.6.2) Df(2R)or-BR11 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)Px2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) In(2LR)ltG10LBR27R (BDGP Project Members, 1994-1999) In(2LR)Px4 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2R)Exel6081 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8700} NA P{KK108942} NA P{UAS-eIF-5A.P} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH2271SH2271 No P{PZ}eIF-5A01296 No P{PZ}eIF-5A10530 No miscellaneous insertions PBac{HpaI-GFP.A}eIF-5ABA00155 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) multicellular organism reproduction inferred from expression pattern (Swanson et al., 2001) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003) wing disc development inferred from genetic interaction with Bx (Bronstein et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
ribosome binding inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189 (FlyBase Curators et al., 2004-) translation elongation factor activity inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189 (FlyBase Curators et al., 2004-) translation initiation factor activity non-traceable author statement (Posey, 1999.6.15) translation regulator activity inferred from sequence or structural similarity with NCBI_gi:4503545 (FlyBase, 1992-)
Biological Process
CV term Evidence References
peptidyl-lysine modification to hypusine inferred from electronic annotation with InterPro:IPR001884 (FlyBase Curators et al., 2004-) positive regulation of translational elongation inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189 (FlyBase Curators et al., 2004-) positive regulation of translational termination inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189 (FlyBase Curators et al., 2004-) translational frameshifting inferred from electronic annotation with InterPro:IPR001884, InterPro:IPR019769, InterPro:IPR020189 (FlyBase Curators et al., 2004-) translational initiation inferred from sequence or structural similarity with NCBI_gi:4503545 (FlyBase, 1992-) non-traceable author statement (Posey, 1999.6.15)
Cellular Component
CV term Evidence References
cytosol non-traceable author statement (Posey, 1999.6.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
eIF-5A - 128up anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - AnxB10 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Ate1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG10638 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - CG10660 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG10958 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG11279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG11523 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) eIF-5A - CG11679 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG12171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG13539 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG13567 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG14024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG14715 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG1971 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG2852 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - CG2862 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - CG2921 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG30393 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG3829 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG4267 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG43795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG4563 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG4813 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5080 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5114 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5380 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5548 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5886 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG5946 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG6084 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - CG6927 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG7048 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG7053 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG7675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG8005 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - CG8680 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Chd64 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Chi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Clic experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Crc experimental knowledge based (Guruharsha et al., 2011) eIF-5A - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Der-2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Df31 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Eno experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Gs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Gαi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Gαo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Hop experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Inos experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Lac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - MFS3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Map205 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Max anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Mdh2 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Moe experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Nacα experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Nlp experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Ocrl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - PH4αSG1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - PHGPx experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Pdi experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Pka-R1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Rab11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Rac1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Rcc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Rheb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - RpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Sh3β experimental knowledge based (Guruharsha et al., 2011) eIF-5A - Snx3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Spf45 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - Vps4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - ave anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - awd experimental knowledge based (Guruharsha et al., 2011) eIF-5A - bsk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - capt experimental knowledge based (Guruharsha et al., 2011) eIF-5A - capu anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - chic experimental knowledge based (Guruharsha et al., 2011) eIF-5A - cib experimental knowledge based (Guruharsha et al., 2011) eIF-5A - dhd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - eya anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - fabp experimental knowledge based (Guruharsha et al., 2011) eIF-5A - l(2)gl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - l(3)02640 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - lwr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - mub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - mus209 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - nemy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - noi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - p38b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - papi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - pio anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - ppa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - regucalcin experimental knowledge based (Guruharsha et al., 2011) eIF-5A - scf experimental knowledge based (Guruharsha et al., 2011) eIF-5A - scu experimental knowledge based (Guruharsha et al., 2011) eIF-5A - scyl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) eIF-5A - smt3 experimental knowledge based (Guruharsha et al., 2011) eIF-5A - εTry anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF-5A allele Gene References eIF-5A01296 png (Lee et al., 2001) eIF-5A10530 png (Lee et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63427 DroID - A comprehensive database of gene and protein interactions. • FBgn0034967 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37846
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG69344G Dipteran inclusive ortholog search EOG6T1HWV Insect inclusive ortholog search EOG61C5SR Arthropod inclusive ortholog search EOG6VMCXS Metazoa inclusive ortholog search EOG6742MK
Orthologs in Drosophila Species (EOG69344G)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\eIF-5A     Drosophila simulans   Dsim\GD11829 Y   Drosophila sechellia   Dsec\GM18297 Y   Drosophila erecta   Dere\GG22930 Y   Drosophila yakuba   Dyak\eIF-5A Y   Drosophila ananassae   Dana\GF24886     Drosophila ananassae   Dana\GF11363 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA16529 Y   Drosophila persimilis   Dper\GL11658 Y   Drosophila willistoni   Dwil\GK21925 Y   Drosophila virilis   Dvir\GJ12476 Y   Drosophila virilis   Dvir\GJ13513     Drosophila mojavensis   Dmoj\GI14044     Drosophila mojavensis   Dmoj\GI16732     Drosophila grimshawi   Dgri\GH23964 Y   Drosophila grimshawi   Dgri\GH15450
Orthologs in non-Drosophila Dipterans (EOG6T1HWV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003835   Anopheles gambiae Malaria mosquito  Agam\AGAP011284   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001289
Orthologs in non-Dipteran Insects (EOG61C5SR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC552572   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006161   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15435   Atta cephalotes Leafcutter ant  Acep\ACEP16763   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21132   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21853   Linepithema humile Argentine ant  Lhum\LH18946   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20133   Solenopsis invicta Red fire ant  Sinv\SINV16327   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002632   Bombyx mori Silkmoth  Bmor\eIF5A   Pediculus humanus Human body louse  Phum\PHUM126820   Tribolium castaneum Red flour beetle  Tcas\TC006406
Orthologs in non-Insect Arthropods (EOG6VMCXS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_231006   Ixodes scapularis Deer tick  Isca\ISCW020373
Orthologs in non-Arthropod Metazoa (EOG6742MK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\iff-2   Caenorhabditis elegans Nematode  Cele\T05G5.10   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003110gn   Danio rerio Zebrafish  Drer\eif5a2   Danio rerio Zebrafish  Drer\eif5a   Xenopus tropicalis Western clawed frog  Xtro\eif5a   Gallus gallus Domestic chicken  Ggal\EIF5A2   Mus musculus House mouse  Mmus\Eif5a   Mus musculus House mouse  Mmus\Eif5a2   Rattus norvegicus Norway rat  Rnor\Eif5a   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022209   Rattus norvegicus Norway rat  Rnor\Eif5a2   Homo sapiens Human  Hsap\EIF5AL1   Homo sapiens Human  Hsap\EIF5A2   Homo sapiens Human  Hsap\EIF5A
Human Orthologs (3)
Gene OMIM HGNC Hsap\EIF5AL1     Hsap\EIF5A2     Hsap\EIF5A
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11829 Drosophila sechellia Dsec\GM18297 Drosophila erecta Dere\GG22930 Drosophila yakuba Dyak\eIF-5A Drosophila ananassae Dana\GF11363 Drosophila pseudoobscura pseudoobscura Dpse\GA16529 Drosophila persimilis Dper\GL11658 Drosophila willistoni Dwil\GK21925 Drosophila virilis Dvir\GJ12476 Drosophila grimshawi Dgri\GH23964
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	39732 y1 w*; P{UAS-eIF-5A.P}4 39731 y1 w*; P{UAS-eIF-5A.P}15 11039 cn1 P{PZ}eIF-5A01296/CyO; ry506
VDRC	v101513 P{KK108942}VIE-260B v25129 w1118; P{GD8700}v25129
Genomic Clones ( 2 )
	BACR27M17 BACR28M05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 456 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE47768
Other clones	yak-ad_eIF yak-em_eIF
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03604 GH06161 GH06753 GH07184 GH08716 GH12851 GH23418 GH26292 GH27378 GH27994 GH28582 GM03262 GM06685 GM07685 GM10273 GM13548 GM15275 GM16588 GM16821 GM17311 GM17867 GM18007 GM22152 GM22545 GM24323 GM24706 GM27661 GM28977 GM29329 GM30492 GM31824 LD07331 LD10009 LD10108 LD22212 LD22271 LD25603 LD26627 LD27208 LD27275 LD29687 LD30313 LD30650 LD30745 LD33579 LD40418 LD43308 LD44928 LP02743 LP03228 LP04685 LP08514 LP10968 LP11883 LP12483 LP16308 LP18556 LP20109 LP23215 RE05641 RE08936 RE10150 RE12754 RE13820 RE15864 RE15892 RE17955 RE18349 RE18831 RE18952 RE19280 RE19758 RE20563 RE21469 RE23118 RE23650 RE24014 RE24775 RE28687 RE30436 RE32054 RE34079 RE35225 RE35443 RE36337 RE36412 RE37488 RE39135 RE39390 RE39762 RE39922 RE41153 RE41434 RE42521 RE43488 RE45374 RE46978 RE47660 RE47708 RE48989 RE50889 RE51808 RE55217 RE59571 RE60596 RE61304 RE61923 RE62194 RE63215 RE63217 RE66019 RE66731 RE69139 RE72121 RE72660 RH08154 RH10629 RH17982 RH41342 RH51717 SD02386 SD04380 SD05031 SD11163 SD11276 SD11527 SD11867 SD12475 SD14328 SD15272 SD15394 SD16887 SD17595 SD17714 SD18857 SD19156 SD19461 SD19771 SD20667 SD20716 SD22658 SD24475 SD24842 SD25050 SD25056 SD25144 SD25860 SD26163 SD26691 SD27802
Other clones	17585 31832 35290 38489 40257 45528 58263 65327 65436 77795 104002 108194 153095 165476 175079 214435.36 283718 522691 527908 527968 533632 542502 542711 AA433269 bs22e12 CK01.13B.A6 CK01.63B.G7 CK01.101C.E8 CK01.146A.E6 CK01934 Dmel_dig_000158_0587_3723 Dmel_dig_001353_0625_3400 Dmel_dig_002323_0583_2208 Dmel_dig_002610_0665_1232 Dmel_dig_007367_0695_1870 Dmel_dig_010184_0694_2719 Dmel_dig_012135_0675_3542 Dmel_dig_014179_0655_1453 Dmel_dig_016539_0617_2607 Dmel_dig_016888_0606_1231 Dmel_dig_019608_0660_0693 Dmel_neb_002981_0617_0653 Dmel_neb_005105_0944_0598 Dmel_neb_005672_0842_1892 Dmel_neb_006221_0661_3057 Dmel_neb_009037_0595_3684 Dmel_neb_009376_0663_1864 Dmel_neb_009849_0623_2040 Dmel_neb_010329_0321_2790 Dmel_neb_011042_0592_2811 Dmel_neb_011341_0626_3423 Dmel_neb_011407_0186_1224 Dmel_neb_011721_0694_2598 Dmel_neb_011833_0192_2348 Dmel_neb_012051_0898_1763 Dmel_neb_012400_0138_2056 Dmel_neb_012607_0658_3546 Dmel_neb_012792_0328_3465 Dmel_neb_012895_0648_2188 Dmel_neb_012987_0168_2699 Dmel_neb_013509_0690_1880 Dmel_neb_013550_0863_2303 Dmel_neb_013592_0399_0786 Dmel_neb_013602_0388_0395 Dmel_neb_013612_0108_3091 Dmel_neb_013632_0117_0503 Dmel_neb_013657_0405_2673 Dmel_neb_013805_0910_3227 Dmel_neb_014120_0422_2956 Dmel_neb_014274_0447_1477 Dmel_neb_014371_0655_2850 Dmel_neb_014505_0084_1291 Dmel_neb_014718_0371_0746 Dmel_neb_014769_0447_1487 Dmel_neb_014970_0370_1877 Dmel_neb_015026_0836_2177 Dmel_neb_015409_0691_2154 Dmel_neb_015497_0207_0566 EC00146 EC00246 EC16496 EC23420 EC24020 EC25808 EC26094 EC26923 EC27071 EC29720 EC30667 EC31568 EC34547 EC34596 EC35934 EC40279 EC40482 EK049003 EK050319 EK078652 EK085737 EK129850 EK142333 EK151535 EK153717 EK161133 EK179531 EK192055 EK211426 EK244664 EK256435 EK270042 EK276458 EK287601 EN02559 EN05302 EN08026 EN08144 EN09912 EN10743 EN11149 EN13401 EP12343 ESG0118d.B21_E10 FGA004D01 FGA008A02 FGB001G12 FGC002G07 FGC003F12 FGC004E11 FGC005H09 FGC007C11 FGC012B08 FGC012H02 FGC013F08 FGC014B02 FGC017H02 FGC019A08 FGC019E09 FGC020G02 FGC023C07 FGC024B04 FGC025C11 FGC026F01 FGC028B05 FGC028B11 FGC030A04 FGC030G05 FGC031C01 FGC032G06 FGC032G10 FGH001B10 FGH001F02 FGH001H10 FGH101C10 FGH103F01 FGH106D03 FGH107D05 FGH110B06 FGH112F04 FGH114E07 FGH119A06 FGH122F02 FGH124B07 FGH126D03 FGH128G03 FGM003E06 FGM103C02 FGM208A07 FGM210A08 FGM210H12 FGM214A03 FGM215F11 FGM217D11 FGM217F04 FGM220D04 FGM220D06 FGM221D06 FGM222B12 FGM227E03 FGM227F06 FGM231B05 FGM232H11 FGM303A07 FGM303F08 FGM305B06 FGM306H07 FGM307A02 FGM311A12 FGM314G04 FGM316E09 FGM325B09 FGX002H01 FGX002H03 GH16179 GM27636 IP03719 IP03819 IP03919 RE02525 RE02957 RE03533 RE03546 RE03720 RE04122 RE05184 RE05345 RE06386 RE09146 RE09201 RE10973 RE11088 RE11263 RE11414 RE13518 RE14481 RE18105 RE19748 RE25465 RE26745 RE26793 RE26957 RE28295 RE29811 RE33536 RE37364 RE40605 RE41186 RE41189 RE47701 RE48951 RE48971 RE50851 RE50871 RE51079 RE51533 RE52215 RE52425 RE53588 RE54302 RE54863 RE54927 RE60350 RE60981 RE62004 RE64277 RE69235 RE71188 RE73849 RH01055 RH01807 RH05228 RH05293 RH06546 RH06739 RH07668 RH07701 RH08151 RH08401 RH15265 RH15877 RH16167 RH22314 RH22920 RH23925 RH25879 RH27128 RH27133 RH30079 RH30563 RH30564 RH30576 RH35146 RH35524 RH38845 RH39069 RH40827 RH44636 RH44654 RH45129 RH47791 RH48275 RH48923 RH50677 RH52125 RH54348 RH55215 RH58358 RH58435 RH59334 RH60057 RH62639 RH62924 RH63094 RH64907 RH70071 RH70466 RH70665 RH73137 RH73303 RH73633 RH74446 UUGC0614 UUGC0620 UUGC1035
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034967 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37846
Antibody Information
	monoclonal (Patel et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: eIF-5A CG3186 (FlyBase, 1996-)
Source for database merge of	Source for merge of: eIF-5A anon-EST:fe2H10 (Bayraktaroglu, 2000.11.2) Source for merge of: eIF-5A l(2)01296 (Misra, 2000.8.25)
Additional comments	Source for identity of eIF-5A CG3186 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	Identification: One of a collection of genes identified with defective larval growth that extend larval life. Not studied further due to problems with background/multiple lesion effects. (Galloni and Edgar, 1999) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138034 NM_166654 RefSeq (Proteins) • NP_611878 NP_726411 DDBJ / EMBL / GenBank • AA433269 AAF47151 AAF80375 AAG17032 AAL49018 AAM68297 AF159443 AF187730 AI533271 AI946248 AY071396 BI363053 G00596 Entrez Gene - A searchable database of RefSeq genes. • 37846 UniProtKB/Swiss-Prot • Q9GU68
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Translation elongation factor IF5A (IPR001884) Translation protein SH3-like domain (IPR008991) Nucleic acid-binding, OB-fold (IPR012340) Ribosomal protein L2 domain 2 (IPR014722) Translation elongation factor, IF5A, hypusine site (IPR019769) Translation elongation factor, IF5A C-terminal (IPR020189) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE47768
Linkouts
	BioGRID - A database of protein and genetic interactions • 63427 DroID - A comprehensive database of gene and protein interactions. • FBgn0034967 DRSC - Results from RNAi screens. • FBgn0034967 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034967 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3186-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034967 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37846 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37846 modMine - Data generated by the modENCODE project. • FBgn0034967
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	1296 (Harvie et al., 1998) anon-EST:fe2H10   CG3186 (Bolshakov et al., 2002, Misra, 2000.8.25, Keleman et al., 2009.8.5, Patel et al., 2009, Bronstein et al., 2010, Cammarato et al., 2011) eIF-5A (Fischer et al., 2012, Buszczak et al., 2007, Parry et al., 2010, Bronstein et al., 2010) eIF5a (Creagh et al., 2009) eIF5A (Patel et al., 2009) l(2)01296 (Spradling et al., 1999, Galloni and Edgar, 1999, Beaton, 1997.12.27, ) unnamed (Schmid and Tautz, 1997)
Name Synonym	anon-fast-evolving-2H10   eIF-5A (Cammarato et al., 2011) eukaryotic initiation factor 5A (Patel et al., 2009) Eukaryotic translation factor 5A (Creagh et al., 2009)
Secondary FlyBase IDs
	FBgn0010483 FBgn0025208
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 14 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Fischer et al., 2012, Proc. Biol. Sci. 279(1738): 2636--2644 Conserved properties of Drosophila and human spermatozoal mRNA repertoires. [FBrf0218415] Show all research papers ...