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Gene Dmel\yki

General Information
Symbol	Dmel\yki	Species	D. melanogaster
Name	yorkie	Annotation symbol	CG4005
Feature type	protein_coding_gene	FlyBase ID	FBgn0034970
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60B7-60B8	Sequence location	2R:19,953,498..19,956,008 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene yorkie is referred to in FlyBase by the symbol Dmel\yki (CG4005, FBgn0034970). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; transcription factor binding; transcription coactivator activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of growth; cell proliferation; morphogenesis of an epithelial sheet; negative regulation of apoptotic process; stem cell proliferation; cell competition in a multicellular organism; positive regulation of glial cell proliferation; regulation of growth. 68 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; imaginal precursor; organ system; adult segment; thoracic segment; portion of tissue; larval head segment; embryonic/larval imaginal precursor; adherens junction; adult; external compound sense organ. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: WW domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628461_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of yki. Gene sequence location is 2R:19953498..19956008.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B7-60B8   Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\yki for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) yki-RD FBtr0290256  NM_138035   1369   343 yki-RF FBtr0290258  NM_001043103   1525   395 yki-RG FBtr0309372  NM_166657   1436   395
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein yki-PD   FBpp0288695   37.8   343   5.34     NP_611879   AAF47156 yki-PF   FBpp0288697   43.6   395   5.04     NP_001036568   ABI31113 yki-PG   FBpp0301274   43.6   395   5.04     NP_726414   AAM68300
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WW domain (IPR001202)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA735440   AE013599 AAF47156   AE013599 AAM68300   AE013599 ABI31113   AI238115   AI258230   AI260337   AI260800   AI261158   AI293780   AI294940   AI455127   AI456831   AI518792   AI533129   AI533516   AY058506 AAL13735   BG641319   BI164163   BI166320   BI237372   BI240779   BI375399   BI481772   BI483114   BI486537   BI579172   BI632125   BI632129   BI632771   BI636692   BI639881   BT029961   BT029965   BT030171   BT132826   CK132154   CK658433   CO267359   CO268595   CO313696   CO339201   CO341878   CZ488917   CZ488918   EC070860   EC070929   EC075751   EC194840   EC202129   EC202758   EC210523   EC242779   EC252958   EC255264   EL886742   GH942733   GH943385   GH948673   GH949810   GH950125   GH952663   GH958494   GH960302   GH976679   GH980464   GH982379
UniProtKB/Swiss-Prot	Q45VV3
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Goulev et al., 2008) nucleus inferred from direct assay (Goulev et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    177.3   NA  Eye    139.225   NA  Brain    341.1   155.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    281.4   NA  Crop    270.8   176.5  Midgut    182.9   199.6  Hindgut    233.1   351.1  Malpighian Tubules    376.4   96.5  Fat Body    64.3   252.6  Salivary Gland    330.7   NA  Heart    102.55   302.4  Trachea    NA   NA  VirginFemale Spermatheca    91.1   NA  InseminatedFemale Spermatheca    99.7   NA  Ovary    361   NA  Testis    202.9   NA  Male Accessory Gland    186.3   187.525  Carcass    120.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female    30 ovary, mated 4-day female    33 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (55) central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female  (30) ovary, mated 4-day female  (33) testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female    30 ovary, mated 4-day female    33 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female    30 ovary, mated 4-day female    33 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female    30 ovary, mated 4-day female    33 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (55) central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female  30 ovary, mated 4-day female  (33) testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female    30 ovary, mated 4-day female    33 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    15 central nervous system, pupae P8    20 head, virgin 1-day female    7 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    11 head, mated 1-day male    12 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    19 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    12 digestive system, 4-day adult    14 digestive system, 20-day adult    18 fat body, larvae L3 wandering    6 fat body, white prepupae    8 fat body, pupae P8    10 carcass, larvae L3 wandering    23 carcass, 1-day adult    8 carcass, 4-day adult    9 carcass, 20-day adult    14 ovary, virgin 4-day female    30 ovary, mated 4-day female    33 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    27 embryo 04-06hr    50 embryo 06-08hr    57 embryo 08-10hr    47 embryo 10-12hr    39 embryo 12-14hr    36 embryo 14-16hr    26 embryo 16-18hr    24 embryo 18-20hr    28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    35 white prepupae new    38 white prepupae 12hr    35 white prepupae 24hr    44 pupae 2d postWPP    44 pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day    33 adult male 30day    32 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  (27) embryo 04-06hr  (50) embryo 06-08hr  (57) embryo 08-10hr  (47) embryo 10-12hr  (39) embryo 12-14hr  (36) embryo 14-16hr  26 embryo 16-18hr    24 embryo 18-20hr  (28) embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  (35) white prepupae new  (38) white prepupae 12hr  (35) white prepupae 24hr  (44) pupae 2d postWPP  (44) pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day  (33) adult male 30day  (32) adult female 01day  (29) adult female 05day  (42) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    27 embryo 04-06hr    50 embryo 06-08hr    57 embryo 08-10hr    47 embryo 10-12hr    39 embryo 12-14hr    36 embryo 14-16hr    26 embryo 16-18hr    24 embryo 18-20hr    28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    35 white prepupae new    38 white prepupae 12hr    35 white prepupae 24hr    44 pupae 2d postWPP    44 pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day    33 adult male 30day    32 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    27 embryo 04-06hr    50 embryo 06-08hr    57 embryo 08-10hr    47 embryo 10-12hr    39 embryo 12-14hr    36 embryo 14-16hr    26 embryo 16-18hr    24 embryo 18-20hr    28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    35 white prepupae new    38 white prepupae 12hr    35 white prepupae 24hr    44 pupae 2d postWPP    44 pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day    33 adult male 30day    32 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    27 embryo 04-06hr    50 embryo 06-08hr    57 embryo 08-10hr    47 embryo 10-12hr    39 embryo 12-14hr    36 embryo 14-16hr    26 embryo 16-18hr    24 embryo 18-20hr    28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    35 white prepupae new    38 white prepupae 12hr    35 white prepupae 24hr    44 pupae 2d postWPP    44 pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day    33 adult male 30day    32 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (63) embryo 02-04hr  27 embryo 04-06hr  (50) embryo 06-08hr  (57) embryo 08-10hr  (47) embryo 10-12hr  (39) embryo 12-14hr  (36) embryo 14-16hr  26 embryo 16-18hr    24 embryo 18-20hr  28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  (35) white prepupae new  (38) white prepupae 12hr  (35) white prepupae 24hr  (44) pupae 2d postWPP  (44) pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day  (33) adult male 30day  32 adult female 01day  29 adult female 05day  (42) adult female 30day  (46) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    27 embryo 04-06hr    50 embryo 06-08hr    57 embryo 08-10hr    47 embryo 10-12hr    39 embryo 12-14hr    36 embryo 14-16hr    26 embryo 16-18hr    24 embryo 18-20hr    28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    35 white prepupae new    38 white prepupae 12hr    35 white prepupae 24hr    44 pupae 2d postWPP    44 pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day    33 adult male 30day    32 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    63 embryo 02-04hr    27 embryo 04-06hr    50 embryo 06-08hr    57 embryo 08-10hr    47 embryo 10-12hr    39 embryo 12-14hr    36 embryo 14-16hr    26 embryo 16-18hr    24 embryo 18-20hr    28 embryo 20-22hr    24 embryo 22-24hr    22 larva L1    18 larva L2    16 larva L3 12hr old    14 larva L3 puffstage 1-2    21 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    35 white prepupae new    38 white prepupae 12hr    35 white prepupae 24hr    44 pupae 2d postWPP    44 pupae 3d postWPP    25 pupae 4d postWPP    20 adult male 01day    24 adult male 05day    33 adult male 30day    32 adult female 01day    29 adult female 05day    42 adult female 30day    46 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    15 embryonic 1182-4H    26 embryonic GM2    21 embryonic Kc167    14 embryonic S1    46 embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (34) Schneider line 2 Sg4    15 embryonic 1182-4H  26 embryonic GM2    21 embryonic Kc167    14 embryonic S1  (46) embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    15 embryonic 1182-4H    26 embryonic GM2    21 embryonic Kc167    14 embryonic S1    46 embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    15 embryonic 1182-4H    26 embryonic GM2    21 embryonic Kc167    14 embryonic S1    46 embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    15 embryonic 1182-4H    26 embryonic GM2    21 embryonic Kc167    14 embryonic S1    46 embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (34) Schneider line 2 Sg4    15 embryonic 1182-4H  26 embryonic GM2    21 embryonic Kc167    14 embryonic S1  (46) embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (39) eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    15 embryonic 1182-4H    26 embryonic GM2    21 embryonic Kc167    14 embryonic S1    46 embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    34 Schneider line 2 Sg4    15 embryonic 1182-4H    26 embryonic GM2    21 embryonic Kc167    14 embryonic S1    46 embryonic S3    16 leg disc CME L1    24 wing disc CME-W2    11 wing disc ML-DmD8    15 wing disc ML-DmD9    16 wing disc ML-DmD16-c3    25 wing disc ML-DmD21    12 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    39 eye-antennal disc ML-DmD11    20 antennal disc ML-DmD20-c5    18 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    15 ovary fGS/OSS    22 ovary OSC    11 ovary OSS    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  (30) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  (30) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (31) Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult  30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3  30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    18 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    14 Cadmium 100 mM 48 hrs, 4-day adult    30 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    6 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    30 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    31 Caffeine 25 mg/ml 48 hrs, 4-day adult    16 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    24 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD21311 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034970 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4005-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for yki Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone ykiΔ.w lethal ykiB5 lethal, with Scer\GAL4GMR.PF ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 lethal, with Scer\GAL4vg.PM ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 lethal (with ykiB5) ykiE271K ykiF351I ykiG347R ykiP88L ykiP295S ykiR310X ykiY282N lethal (with ykiE271K) ykiB5 lethal (with ykiF351I) ykiB5 lethal (with ykiG347R) ykiB5 lethal (with ykiP88L) ykiB5 lethal (with ykiP295S) ykiB5 lethal (with ykiR310X) ykiB5 lethal (with ykiY282N) ykiB5 lethal | embryonic stage ykiΔ.w lethal | first instar larval stage ykiΔ.w lethal | larval stage, with Scer\GAL4sd-SG29.1 ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 lethal | partially, with Scer\GAL4GMR.PF ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 lethal | partially, with Scer\GAL4sd-SG29.1 ykiS111A.S250A.Scer\UAS.T:SV5\V5 lethal | pupal stage, with Scer\GAL4pnr-MD237 ykiGD11187 lethal | pupal stage, with Scer\GAL4repo.PU ykiKK109756 lethal | somatic clone ykiS168A.αTub84B Other Phenotypes Allele cell shape defective | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa cell shape defective | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa cell size defective | somatic clone ykiB5 decreased cell death, with Scer\GAL4GMR.PF ykiScer\UAS.cHa decreased cell death | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa decreased cell number | somatic clone ykiB5 decreased cell number | third instar larval stage, with Scer\GAL4repo.PU ykiKK109756 hyperplasia, with Scer\GAL4GMR.PF ykiScer\UAS.cZb ykiΔ.Scer\UAS hyperplasia | somatic clone ykiS168A.αTub84B hyperplasia | somatic clone, with Scer\GAL4αTub84B.PP ykiScer\UAS.cHa increased cell number, with Scer\GAL4C5 ykiS97A.Scer\UAS ykiScer\UAS.T:SV5\V5 ykiW1W2.Scer\UAS increased cell number, with Scer\GAL4GMR.PF ykiScer\UAS.cHa increased cell number, with Scer\GAL4Scer\FRT.Act5C ykiScer\UAS.T:SV5\V5 ykiW1W2.Scer\UAS increased cell number | pupal stage, with Scer\GAL4GMR.PF ykiS168A.Scer\UAS.T:Avic\GFP-YFP increased cell number | somatic clone, with Scer\GAL4esg-NP5130 ykiScer\UAS.cZa increased cell number | somatic clone, with Scer\GAL4Myo31DF-NP0001, Scer\GAL80ts.αTub84B ykiScer\UAS.cZa increased cell number | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 increased cell number | somatic clone, with Scer\GAL4αTub84B.PL ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiScer\UAS.cHa increased cell number | third instar larval stage, with Scer\GAL4repo.PU ykiS168A.Scer\UAS.T:SV5\V5 increased cell size | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa increased cell size | somatic clone, with Scer\GAL4αTub84B.PP ykiScer\UAS.cHa mitotic cell cycle defective | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa mitotic cell cycle defective | somatic clone, with Scer\GAL4esg-NP5130 ykiScer\UAS.cZa mitotic cell cycle defective | somatic clone, with Scer\GAL4Myo31DF-NP0001, Scer\GAL80ts.αTub84B ykiScer\UAS.cZa neuroanatomy defective | larval stage, with Scer\GAL4C855a ykiS168A.Scer\UAS.T:Disc\RFP size defective, with Scer\GAL4GMR.PF ykiS168A.Scer\UAS.T:Avic\GFP-YFP ykiScer\UAS.cHa ykiScer\UAS.T:Avic\GFP-YFP size defective, with Scer\GAL4hh-Gal4 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiScer\UAS.cHa size defective, with Scer\GAL4ptc-559.1 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 size defective | adult stage, with Scer\GAL4GMR.PF ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 ykiScer\UAS.cZa size defective | larval stage, with Scer\GAL4GMR.PFa ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 size defective | somatic clone ykiB5 tumorigenic, with Scer\GAL4Act5C.PI ykiS168A.Scer\UAS.T:SV5\V5 visible, with Scer\GAL4ey.PH ykidsRNA.C.Scer\UAS ykidsRNA.N.Scer\UAS visible, with Scer\GAL4GMR.PF yki3SA.Scer\UAS.cRa.T:Hsap\MYC ykiM1.Scer\UAS.T:Hsap\MYC ykiM12.Scer\UAS.T:Hsap\MYC ykiM123.Scer\UAS.T:Hsap\MYC ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.cRa.T:Hsap\MYC ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.cRa.T:Hsap\MYC ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiS168A.Scer\UAS.T:Avic\GFP-YFP ykiS168A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 ykiScer\UAS.cHa ykiScer\UAS.cRa.T:Hsap\MYC ykiScer\UAS.cZa ykiScer\UAS.T:Avic\GFP-YFP ykiScer\UAS.T:Hsap\MYC ykiScer\UAS.T:SV5\V5 visible, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 visible, with Scer\GAL4GMR.PU ykiScer\UAS.cHa ykiScer\UAS.cZa visible, with Scer\GAL4ptc-559.1 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 visible, with Scer\GAL4sd-SG29.1 ykiS111A.S168A.S250A-WW.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 visible | adult stage, with Scer\GAL4GMR.PF ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 ykiScer\UAS.cZa visible | somatic clone, with Scer\GAL4tub.PU ykiM123.Scer\UAS.T:Hsap\MYC Phenotype manifest in Allele adherens junction, with Scer\GAL4en-e16E ykiScer\UAS.cHa adult cuticle | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa adult head | somatic clone ykiS168A.αTub84B embryonic/larval brain | third instar larval stage, with Scer\GAL4repo.PU ykiKK109756 ykiS168A.Scer\UAS.T:SV5\V5 embryonic/larval glial cell | third instar larval stage, with Scer\GAL4repo.PU ykiKK109756 ykiS168A.Scer\UAS.T:SV5\V5 embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4repo.PU ykiS168A.Scer\UAS.T:SV5\V5 epithelial cell | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa eye ykiΔ.w eye, with Scer\GAL4ey.PH ykidsRNA.N.Scer\UAS ykidsRNA.C.Scer\UAS eye, with Scer\GAL4GMR.PF ykiScer\UAS.T:Hsap\MYC ykiScer\UAS.cZa ykiM1.Scer\UAS.T:Hsap\MYC ykiM12.Scer\UAS.T:Hsap\MYC ykiM123.Scer\UAS.T:Hsap\MYC ykiScer\UAS.cHa ykiScer\UAS.cRa.T:Hsap\MYC ykiS168A.Scer\UAS.cRa.T:Hsap\MYC ykiS111A.S250A.Scer\UAS.cRa.T:Hsap\MYC yki3SA.Scer\UAS.cRa.T:Hsap\MYC ykiΔ.Scer\UAS ykiScer\UAS.T:SV5\V5 ykiScer\UAS.T:Avic\GFP-YFP ykiS168A.Scer\UAS.T:Avic\GFP-YFP ykiScer\UAS.cZb ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiS250A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 eye, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL ykiS168A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 eye, with Scer\GAL4GMR.PU ykiScer\UAS.cZa ykiScer\UAS.cHa eye, with Scer\GAL4ptc-559.1 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 eye | pupal stage | somatic clone, with Scer\GAL4αTub84B.PL ykiScer\UAS.cHa eye | somatic clone ykiS168A.αTub84B eye | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiW1W2.Scer\UAS ykiScer\UAS.T:SV5\V5 eye | somatic clone, with Scer\GAL4tub.PU ykiM123.Scer\UAS.T:Hsap\MYC eye-antennal disc, with Scer\GAL4GMR.PF ykiScer\UAS.cHa eye disc, with Scer\GAL4GMR.PF ykiScer\UAS.cZa eye disc | larval stage, with Scer\GAL4GMR.PFa ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 eye disc | somatic clone ykiB5 ykiS168A.αTub84B eye disc | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa eye disc | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa eye disc | somatic clone | third instar larval stage ykiB5 eye disc | third instar larval stage, with Scer\GAL4repo.PU ykiKK109756 ykiS168A.Scer\UAS.T:SV5\V5 eye disc posterior to the morphogenetic furrow, with Scer\GAL4GMR.PF ykiScer\UAS.cHa follicle cell, with Scer\GAL4Act5C.PI ykiS168A.Scer\UAS.T:SV5\V5 haltere, with Scer\GAL4ptc-559.1 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 haltere | somatic clone ykiS168A.αTub84B interommatidial bristle | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiScer\UAS.T:SV5\V5 interommatidial bristle | supernumerary, with Scer\GAL4GMR.PF ykiScer\UAS.cHa inter-ommatidial cell | pupal stage, with Scer\GAL4GMR.PF ykiS168A.Scer\UAS.T:Avic\GFP-YFP intestinal stem cell | somatic clone, with Scer\GAL4esg-NP5130 ykiScer\UAS.cZa intestinal stem cell | somatic clone, with Scer\GAL4Myo31DF-NP0001, Scer\GAL80ts.αTub84B ykiScer\UAS.cZa larval inner optic anlage, with Scer\GAL4C855a ykiS168A.Scer\UAS.T:Disc\RFP larval outer optic anlage, with Scer\GAL4C855a ykiS168A.Scer\UAS.T:Disc\RFP leg, with Scer\GAL4ptc-559.1 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 leg | somatic clone ykiS168A.αTub84B mesothoracic tergum | somatic clone ykiS168A.αTub84B pigment cell | supernumerary, with Scer\GAL4GMR.PF ykiScer\UAS.cHa ventral nerve cord | third instar larval stage, with Scer\GAL4repo.PU ykiKK109756 ykiS168A.Scer\UAS.T:SV5\V5 wing, with Scer\GAL471B ykiΔ.Scer\UAS ykiScer\UAS.cZb wing, with Scer\GAL4C5 ykiW1W2.Scer\UAS ykiS97A.Scer\UAS ykiScer\UAS.T:SV5\V5 wing, with Scer\GAL4sd-SG29.1 ykiS111A.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS111A.S168A.S250A-WW.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 wing | somatic clone ykiS168A.αTub84B wing | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiW1W2.Scer\UAS ykiScer\UAS.T:SV5\V5 wing disc, with Scer\GAL4hh-Gal4 ykiScer\UAS.cHa ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 wing disc, with Scer\GAL4ptc-559.1 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 wing disc | cell autonomous | somatic clone ykiB5 wing disc | cell autonomous | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa wing disc | cell non-autonomous | somatic clone ykiB5 wing disc | cell non-autonomous | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa wing disc | posterior compartment, with Scer\GAL4hh-Gal4 ykiScer\UAS.cZa wing disc | somatic clone ykiB5 wing disc | somatic clone, with Scer\GAL4Act5C.PI ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiS111A.S250A.Scer\UAS.T:SV5\V5 wing disc | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa wing disc | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiS250A.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 wing disc | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa wing disc | somatic clone, with Scer\GAL4αTub84B.PL ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 wing disc | third instar larval stage ykiΔ.w
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of yki Class Mutagen Stocks Known lesion ykiB5 loss of function allele 1 -- ykif06249 piggyBac transposase 1 -- ykiMB09079 1 -- ykiDbo1 0 Yes ykiDbo2 0 Yes ykiDbo3 0 Yes ykiE271K ethyl methanesulfonate 0 Yes ykiF351I ethyl methanesulfonate 0 Yes ykiG347R ethyl methanesulfonate 0 Yes ykiP295S ethyl methanesulfonate 0 Yes ykiP88L ethyl methanesulfonate 0 Yes ykiR310X ethyl methanesulfonate 0 Yes ykiY282N ethyl methanesulfonate 0 Yes ykiΔ.w recombination SCEI endonuclease FLPase ends-out gene targeting 0 Yes
Alleles Carried on Transgenic Constructs ( 54 )
For All Alleles Carried on Transgenic Constructs Show
Allele of yki Class Mutagen Stocks Known lesion ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes ykiGD11187 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiHMS00041 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiJF03119 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiKK109756 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes ykiS168A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes ykiScer\UAS.cOa.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes ykiScer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes yki-WW.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes yki1-418.T:Scer\GAL4 in vitro construct - regulatory fusion 0 Yes yki3SA.Scer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykidsRNA.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ykidsRNA.N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ykiGMR.PH in vitro construct - regulatory fusion 0 Yes ykiM1.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM12.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM123.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM2.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM3.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiNIG.4005R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ykiS111A.S168A.S250A-WW.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.S168A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.S250A.Scer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.S250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.S250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\FRT.αTub84B in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.αTub84B FLPase 0 Yes ykiS169A.S172A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS169D.S172D.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS97A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes ykiScer\FRT.D.αTub84B in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.cZb in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiw.Scer\SceI.RS in vitro construct 0 Yes ykiW1W2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiWW12.Scer\UAS.T:Avic\GFP-YFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiWW12.Scer\UAS 0 -- ykiαTub84B.PD FLPase 0 Yes ykiαTub84B.PH in vitro construct - regulatory fusion 0 Yes ykiΔ.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6081 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-Myc-yki.3SA} NA M{UAS-Myc-yki.S111A.S250A} NA M{UAS-Myc-yki.S168A} NA M{UAS-Myc-yki} NA P{GD11187} NA P{KK109756} NA P{TRiP.HMS00041} NA P{TRiP.JF03119} NA P{UAS-yki.Fg} NA P{UAS-yki.GFP} NA P{UAS-yki.M1.Myc} NA P{UAS-yki.M2.Myc} NA P{UAS-yki.M3.Myc} NA P{UAS-yki.M12.Myc} NA P{UAS-yki.M123.Myc} NA P{UAS-yki.Myc} NA P{UAS-yki.RNAi.C} NA P{UAS-yki.RNAi.N} NA P{UAS-yki.S97A} NA P{UAS-yki.S111A.S168A.S250A.V5} NA P{UAS-yki.S111A.S168A.S250A-WW.V5} NA P{UAS-yki.S111A.S168A.V5} NA P{UAS-yki.S111A.S250A.V5} NA P{UAS-yki.S111A.V5} NA P{UAS-yki.S168A.GFP.HA} NA P{UAS-yki.S168A.RFP} NA P{UAS-yki.S168A.S250A.V5} NA P{UAS-yki.S168A.V5} NA P{UAS-yki.S168A.YFP} NA P{UAS-yki.S168A} NA P{UAS-yki.S169A.S172A.V5} NA P{UAS-yki.S169D.S172D.V5} NA P{UAS-yki.S250A.V5} NA P{UAS-yki.V5.O} NA P{UAS-yki.V5} NA P{UAS-yki.W1W2} NA P{UAS-yki.WW12.YFP} NA P{UAS-yki.WW12} NA P{UAS-yki.-WW.V5} NA P{UAS-yki.YFP} NA P{UAS-yki.Z} NA P{UAS-yki.Zb} NA P{UAS-yki.ΔC} NA P{UAS-yki} NA characterization construct P{FRT(yki.Scer\SceI.RS)} NA P{NIG.4005R} NA P{tub(FRT.y+)yki.D} NA P{tub(FRT.y+)yki.S168A} NA P{tub(-FRT)yki.D} NA P{tub(-FRT)yki.S168A} NA P{tub-yki.H} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}ykif06249 NA insertion of enhancer trap binary system Mi{ET1}ykiMB09079 No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:P29310 (assigned by UniProtKB) (Oh and Irvine, 2008) inferred from physical interaction with UniProtKB:P92177 (assigned by UniProtKB) (Oh and Irvine, 2008) transcription coactivator activity inferred from direct assay (Goulev et al., 2008) transcription factor binding inferred from physical interaction with sd (Goulev et al., 2008)
Biological Process
CV term Evidence References
cell competition in a multicellular organism inferred from mutant phenotype (Ziosi et al., 2010) cell proliferation inferred from mutant phenotype (Huang et al., 2005, Thompson and Cohen, 2006) morphogenesis of an epithelial sheet inferred from mutant phenotype (Thompson and Cohen, 2006) negative regulation of apoptotic process inferred from mutant phenotype (Huang et al., 2005, Thompson and Cohen, 2006) positive regulation of glial cell proliferation inferred from mutant phenotype (Reddy and Irvine, 2011) positive regulation of growth inferred from mutant phenotype (Oh and Irvine, 2011) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Goulev et al., 2008) regulation of growth inferred from mutant phenotype (Nolo et al., 2006) stem cell proliferation inferred from direct assay (Ren et al., 2010)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Goulev et al., 2008) nucleus inferred from direct assay (Goulev et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transcription coactivator activity non-traceable author statement (Jukam et al., 2006) ubiquitin-protein ligase activity inferred from sequence or structural similarity with Saccharomyces RSP5 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of rhodopsin gene expression non-traceable author statement (Jukam et al., 2006)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
yki - Ack anti tag coimmunoprecipitation, peptide massfingerprinting (Schoenherr et al., 2012) yki - CG10889 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - CG1688 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - CG7669 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - Mdh2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - RpS15Ab experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) yki - Wbp2 anti tag coimmunoprecipitation, anti tag western blot (Zhang et al., 2011) yki - nerfin-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - ovo anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) yki - stv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions yki allele Gene References unspecified ban (Thompson and Cohen, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63430 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034970 DroID - A comprehensive database of gene and protein interactions. • FBgn0034970 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37851 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q45VV3
Orthologs
OrthoDB Orthologs (15) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG602XC2 Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG63JB2X Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG602XC2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\yki     Drosophila simulans   Dsim\GD24973 Y   Drosophila sechellia   Dsec\GM18275 Y   Drosophila erecta   Dere\GG19955 Y   Drosophila yakuba   Dyak\GE11487 Y   Drosophila ananassae   Dana\GF13481 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17846 Y   Drosophila persimilis   Dper\GL10424 Y   Drosophila willistoni   Dwil\GK21386 Y   Drosophila virilis   Dvir\GJ20440 Y   Drosophila mojavensis   Dmoj\GI18856 Y   Drosophila grimshawi   Dgri\GH20170 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG63JB2X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11890   Solenopsis invicta Red fire ant  Sinv\SINV23437   Bombyx mori Silkmoth  Bmor\BGIBMGA003681
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24973 Drosophila sechellia Dsec\GM18275 Drosophila erecta Dere\GG19955 Drosophila yakuba Dyak\GE11487 Drosophila ananassae Dana\GF13481 Drosophila pseudoobscura pseudoobscura Dpse\GA17846 Drosophila persimilis Dper\GL10424 Drosophila willistoni Dwil\GK21386 Drosophila virilis Dvir\GJ20440 Drosophila mojavensis Dmoj\GI18856 Drosophila grimshawi Dgri\GH20170
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	28819 w*; P{UAS-yki.V5.O}attP2 36290 l(2)gl4 ykiB5/CyO 28818 w*; P{UAS-yki.S168A.V5}attP2 28815 y1 w*; P{UAS-yki.GFP}4-12-1 34067 y1 v1; P{TRiP.HMS00041}attP2 26142 w1118; Mi{ET1}ykiMB09079/SM6a 28817 w*; P{UAS-yki.S111A.S168A.S250A.V5}attP2 28816 y1 w*; P{UAS-yki.S168A.GFP.HA}10-7-Y 28836 y1 w*; P{UAS-yki.S168A.GFP.HA}10-12-1
Harvard	- PBac{WH}ykif06249
VDRC	v104523 P{KK109756}VIE-260B v40497 w1118; P{GD11187}v40497/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR27M17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 60 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21311
Other clones	DPiM_LD21311 FI16856 IP17673 IP17773 IP17873
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14114 LD36972 LD38548 LP01119 LP01370 LP04136 LP04779 LP06995 LP08432 LP13453 LP15346 RE03771 RE06409 RE33590 RE37695 RE63188 RE64373 RE65955 RE69979 RE73160 SD04845 SD05370 SD12639 SD18481 SD22581 SD25726 SD25730 SD26638
Other clones	37662 81313 99988 107884 214443.75 214443.76 CK01.23B.B2 CK01.108A.C3 CK01.109C.D9 EK092110 EK149546 EK233751 EP01054 EP13331 IP17973 RP004032009 RP004140424 RP004176597 RP004180677 RP004194912 RP004222528 RP004241324 RP004251316 RP004256053 RP004312853 RP004546646
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034970 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37851
Antibody Information
	polyclonal (Oh and Irvine, 2008)
Other Information
Discoverer
Etymology
	This gene is named "yorkie" after Yorkshire Terriers, one of the World's smallest breeds of pet dogs, according to its loss-of-function phenotype. (Huang et al., 2005)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: yki CG4005 (Jukam, 2006.3.1) Source for identity of: yki CG4005 (Huang et al., 2005)
Source for database merge of
Additional comments
Other Comments
	The competitive properties of yki-expressing cells is extremely reduced when they are surrounded by cells expressing very high amounts of dm. (Ziosi et al., 2010) yki regulates expression of the ban miRNA. (Nolo et al., 2006) yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway. (Huang et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138035 NM_166657 NM_001043103 RefSeq (Proteins) • NP_611879 NP_726414 NP_001036568 DDBJ / EMBL / GenBank • AA735440 AAF47156 AAL13735 AAM68300 ABI31113 AI455127 AY058506 CZ488917 CZ488918 Entrez Gene - A searchable database of RefSeq genes. • 37851 UniProtKB/Swiss-Prot • Q45VV3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WW domain (IPR001202) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD21311
Linkouts
	BioGRID - A database of protein and genetic interactions • 63430 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034970 DroID - A comprehensive database of gene and protein interactions. • FBgn0034970 DRSC - Results from RNAi screens. • FBgn0034970 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034970 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4005-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034970 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37851 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/yorkie1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37851 modMine - Data generated by the modENCODE project. • FBgn0034970 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q45VV3
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG4005 (Robertson, 2001.5.6, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) yap (Bennett and Harvey, 2006) Yki (Richter et al., 2011, Wei et al., 2007, Edgar, 2006, Shimizu et al., 2008, Truscott et al., 2011, Polesello et al., 2006, Hariharan, 2006, Zhang et al., 2011, Oh and Irvine, 2011, Wei et al., 2007, Zhang et al., 2008, Rogulja et al., 2008, Dutta and Baehrecke, 2008, Oh and Irvine, 2009, Hamaratoglu et al., 2009, Zhang et al., 2009, Zhang et al., 2008, Willecke et al., 2006, Grzeschik et al., 2010, Ren et al., 2010, Ho et al., 2010, Yu et al., 2010, Hall et al., 2010, Rauskolb et al., 2011, Yue et al., 2012, Gilbert et al., 2011, Zhai et al., 2008, Tokusumi et al., 2012, Chen et al., 2012, Jin et al., 2012) yki (Morrison and Halder, 2010, Silva et al., 2006, Bennett and Harvey, 2006, Yu et al., 2008, Schoenherr et al., 2012, Zhai et al., 2012, Dong et al., 2007, Estella and Mann, 2010, Silva, 2006, Fernández et al., 2011, Zhao et al., 2007, Sun et al., 2008, Kawamori et al., 2011, Zhang et al., 2011, Nicolay and Frolov, 2008, Shaw et al., 2010, Shcherbata et al., 2007, Emoto et al., 2006, Wu et al., 2008, Oh and Irvine, 2008, Polesello and Tapon, 2007, Meignin et al., 2007, Goulev et al., 2008, Poernbacher et al., 2012, Zhao et al., 2008, Badouel et al., 2009, Zhao et al., 2009, Hamaratoglu et al., 2009, Peng et al., 2009, Baena-Lopez et al., 2008, Cho et al., 2006, Gilbert et al., 2009, Gilbert et al., 2009, Zhang et al., 2009, Das Thakur et al., 2010, Robinson et al., 2010, Fang and Adler, 2010, Genevet et al., 2009, Yu et al., 2010, Baumgartner et al., 2010, Varelas et al., 2010, Genevet et al., 2010, Zecca and Struhl, 2010, Baumgartner et al., 2010, Beam and Moberg, 2010, Genevet et al., 2010, Kagey et al., 2012, Ribeiro et al., 2010, Menéndez et al., 2010, Chen et al., 2010, Milton et al., 2010, Reddy et al., 2010, Nicolay et al., 2010, Ziosi et al., 2010, Neto-Silva et al., 2010, Zhang et al., 2012, Grusche et al., 2011, Boggiano et al., 2011, Ren et al., 2010, Benseñor et al., 2010, Gilbert et al., 2011, Reddy and Irvine, 2011, Gerhold et al., 2011, Chen and Verheyen, 2012, Ye et al., 2012, Verghese et al., 2012) YKI (Zeng et al., 2010)
Name Synonym	yorkie (Huang et al., 2005, Jukam, 2006.3.1, Jukam et al., 2006, Nolo et al., 2006, Jukam and Desplan, 2007, Morrison and Halder, 2010, Bennett and Harvey, 2006, Sun et al., 2008, Huang et al., 2008, Goulev et al., 2008, Peng et al., 2009, Zhang et al., 2009, Das Thakur et al., 2010, Fang and Adler, 2010, Menéndez et al., 2010, Chen et al., 2010, Reddy et al., 2010, Zeng et al., 2010, Benseñor et al., 2010, Gerhold et al., 2011, Graves et al., 2012, Verghese et al., 2012) Yorkie (Wei et al., 2007, Thompson and Cohen, 2006, Edgar, 2006, Colombani et al., 2006, Hamaratoglu et al., 2007, Willecke et al., 2007, Schoenherr et al., 2012, Dong et al., 2007, Polesello et al., 2006, Hariharan, 2006, Oh et al., 2009, Zhang et al., 2008, Oh and Irvine, 2008, Polesello and Tapon, 2007, Meignin et al., 2007, Dutta and Baehrecke, 2008, Badouel et al., 2009, Oh and Irvine, 2009, Hamaratoglu et al., 2009, Zhang et al., 2009, Cho et al., 2006, Willecke et al., 2006, Grzeschik et al., 2010, Robinson et al., 2010, Ren et al., 2010, Ho et al., 2010, Yu et al., 2010, Baumgartner et al., 2010, Varelas et al., 2010, Genevet et al., 2010, Zecca and Struhl, 2010, Fang and Adler, 2010, Milton et al., 2010, Ziosi et al., 2010, Neto-Silva et al., 2010, Zhang et al., 2012, Poon et al., 2011, Reddy and Irvine, 2011, Chen et al., 2012, Jin et al., 2012)
Secondary FlyBase IDs
References ( 148 )
Generate a list of	All references relating to this gene ( 148 )
List References by type	Research paper  ( 112 ) Supplementary material  ( 12 ) Review  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 43 )
	Sansores-Garcia et al., 2013, Curr. Biol. 23(3): 229--235 Mask Is Required for the Activity of the Hippo Pathway Effector Yki/YAP. [FBrf0220780] Bayarmagnai et al., 2012, Cell Cycle 11(22): 4191--4202 Drosophila GAGA factor is required for full activation of the dE2f1-Yki/Sd transcriptional program. [FBrf0220001] Chen et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(2): 484--489 Tumor suppression by cell competition through regulation of the Hippo pathway. [FBrf0217148] Chen and Verheyen, 2012, Curr. Biol. 22(17): 1582--1586 Homeodomain-interacting protein kinase regulates yorkie activity to promote tissue growth. [FBrf0219448] Denton et al., 2012, Cell Death Differ. 19(8): 1299--1307 Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila. [FBrf0218812] Graves et al., 2012, PLoS ONE 7(6): e37615 Notch signaling activates yorkie non-cell autonomously in Drosophila. [FBrf0218547] Jin et al., 2012, J. Biol. Chem. 287(8): 5784--5796 Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control. [FBrf0217990] Kagey et al., 2012, Mech. Dev. 129(9-12): 339--349 Regulation of Yorkie activity in Drosophila imaginal discs by the Hedgehog receptor gene patched. [FBrf0219794] Poernbacher et al., 2012, Curr. Biol. 22(5): 389--396 Drosophila Pez acts in hippo signaling to restrict intestinal stem cell proliferation. [FBrf0217766] Rodrigues et al., 2012, Development 139(21): 4051--4061 Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis. [FBrf0219660] Schoenherr et al., 2012, PLoS Genet. 8(5): e1002725 Drosophila activated cdc42 kinase has an anti-apoptotic function. [FBrf0218372] Sebé-Pedrós et al., 2012, Cell Rep. 1(1): 13--20 Premetazoan origin of the hippo signaling pathway. [FBrf0219051] Straßburger et al., 2012, Dev. Biol. 367(2): 187--196 Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP. [FBrf0218526] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Verghese et al., 2012, Cell Death Differ. 19(10): 1664--1676 Hippo signalling controls Dronc activity to regulate organ size in Drosophila. [FBrf0219371] Verghese et al., 2012, PLoS ONE 7(11): e47173 Scribble acts in the Drosophila fat-hippo pathway to regulate warts activity. [FBrf0219901] Ye et al., 2012, Dev. Biol. 369(1): 115--123 Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila. [FBrf0219022] Yue et al., 2012, Dev. Cell 22(2): 255--267 The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the hippo signaling pathway. [FBrf0217474] Zhai et al., 2012, PLoS Genet. 8(3): e1002582 Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859] Zhang et al., 2012, PLoS ONE 7(2): e31994 Control of tissue growth and cell transformation by the salvador/warts/hippo pathway. [FBrf0217552] Boggiano et al., 2011, Dev. Cell 21(5): 888--895 Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. [FBrf0217346] Brás-Pereira et al., 2011, Commun. Integr. Biol. 4(5): 612--615 Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway. [FBrf0216670] Doggett et al., 2011, BMC Dev. Biol. 11: 57 Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. [FBrf0216618] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Gerhold et al., 2011, Genetics 189(4): 1309--1326 Identification and characterization of genes required for compensatory growth in Drosophila. [FBrf0217000] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. [FBrf0216680] Kawamori et al., 2011, Dev. Growth Differ. 53(5): 653--667 Fat / Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe. [FBrf0213932] Napoletano et al., 2011, EMBO J. 30(5): 945--958 Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. [FBrf0213147] Nicolay et al., 2011, Genes Dev. 25(4): 323--335 Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. [FBrf0214348] Oh and Irvine, 2011, Dev. Cell 20(1): 109--122 Cooperative Regulation of Growth by Yorkie and Mad through bantam. [FBrf0212763] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Rauskolb et al., 2011, PLoS Biol. 9(6): e1000624 Zyxin links fat signaling to the hippo pathway. [FBrf0213900] Reddy and Irvine, 2011, Development 138(23): 5201--5212 Regulation of Drosophila glial cell proliferation by Merlin-Hippo signaling. [FBrf0216584] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Robinson and Moberg, 2011, Cell Cycle 10(23): 4110--4118 Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. [FBrf0217243] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Sun and Irvine, 2011, Dev. Biol. 350(1): 139--151 Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. [FBrf0212753] Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 mir-11 limits the proapoptotic function of its host gene, dE2f1. [FBrf0215211] Willecke et al., 2011, Oncogene 30(39): 4067--4074 Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. [FBrf0216281] Zhang et al., 2011, Cell Death Differ. 18(8): 1346--1355 Wbp2 cooperates with Yorkie to drive tissue growth downstream of the Salvador-Warts-Hippo pathway. [FBrf0214266] Zhang et al., 2011, PLoS ONE 6(7): e22278 Yki/YAP, Sd/TEAD and Hth/MEIS Control Tissue Specification in the Drosophila Eye Disc Epithelium. [FBrf0214606] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...