General Information
Symbol
Dmel\yki
Species
D. melanogaster
Name
yorkie
Annotation Symbol
CG4005
Feature Type
FlyBase ID
FBgn0034970
Gene Model Status
Stock Availability
Gene Snapshot
Yorkie is a transcriptional co-activator protein that is negatively regulated by Hippo signaling, which promotes its cytoplasmic localization. It functions together with DNA binding proteins, such as sd, to activate transcription of a wide range of downstream targets, including genes that promote growth. [Date last reviewed: 2016-06-30]
Also Known As
YAP
Genomic Location
Cytogenetic map
Sequence location
2R:24,065,975..24,068,485 [-]
Recombination map
2-106
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the YAP1 family. (Q45VV3)
Protein Domains/Motifs
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
UniProt Contributed Function Data
Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein. The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam. Regulates the expression of G1/S-specific cyclin-E (CycE) and apoptosis 1 inhibitor (th), thereby promoting cell proliferation and inhibiting apoptosis. Required for transcriptional activity of scalloped (sd) in wing imaginal disks. Induces expression of expression of vestigial (vg) in wing and haltere disks and the expression of transcription factor E2f (E2f).
(UniProt, Q45VV3)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\yki or the JBrowse view of Dmel\yki for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.40
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Gene model reviewed during 6.14
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0290256
1369
343
FBtr0290258
1525
395
FBtr0309372
1460
395
FBtr0452181
1525
418
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0288695
37.8
343
5.34
FBpp0288697
43.6
395
5.04
FBpp0301274
43.6
395
5.04
FBpp0402906
46.2
418
5.37
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

395 aa isoforms: yki-PF, yki-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Interacts (via WW domains) with wts. Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd. The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta.
(UniProt, Q45VV3)
Post Translational Modification
Its activity is regulated by multiple phosphorylation events. Phosphorylation at Ser-88, Ser-145 and Ser-227 negatively regulate its activity and restrict its nuclear localization. Wts-mediated phosphorylation at Ser-145 promotes interaction with 14-3-3epsilon and 14-3-3zeta. Phosphorylation at Ser-88 and Ser-227 regulate nuclear localization and activity independent of 14-3-3 association.
(UniProt, Q45VV3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\yki using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (28 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:Q9VZI2
(assigned by UniProt )
inferred from physical interaction with FLYBASE:Ncoa6; FB:FBgn0031698
inferred from physical interaction with UniProtKB:P51140
(assigned by BHF-UCL )
inferred from physical interaction with FLYBASE:ex; FB:FBgn0004583
inferred from physical interaction with UniProtKB:P25439
inferred from physical interaction with UniProtKB:P29310
(assigned by UniProt )
inferred from physical interaction with UniProtKB:P92177
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q07436
(assigned by UniProt )
inferred from physical interaction with UniProtKB:P30052
(assigned by UniProt )
inferred from mutant phenotype
(assigned by UniProt )
inferred from physical interaction with UniProtKB:O46339
inferred from physical interaction with FLYBASE:sd; FB:FBgn0003345
Terms Based on Predictions or Assertions (0 terms)
Biological Process (17 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
colocalizes_with cytoplasmic vesicle
inferred from direct assay
colocalizes_with late endosome
inferred from direct assay
colocalizes_with lysosome
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Expression Data
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
(assigned by UniProt )
colocalizes_with cytoplasmic vesicle
inferred from direct assay
colocalizes_with late endosome
inferred from direct assay
colocalizes_with lysosome
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\yki in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 16 )
Transgenic Constructs ( 68 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of yki
Allele of yki
Mutagen
Associated Transgenic Construct
Stocks
Transgenic constructs containing regulatory region of yki
Deletions and Duplications ( 1 )
Summary of Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
interommatidial bristle | somatic clone, with Scer\GAL4FRT.Act5C
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
11 of 15
Yes
Yes
 
7 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (13)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
6 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (11)
9 of 13
Yes
Yes
8 of 13
No
Yes
1 of 13
No
No
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
5 of 12
Yes
Yes
5 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (13)
11 of 15
Yes
Yes
8 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
3 of 15
Yes
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No orthologs reported.
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No orthologs reported.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919092W )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504EX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W063A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05YT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G095A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Human Disease Model Data
FlyBase Human Disease Model Reports
Alleles Reported to Model Human Disease (Disease Ontology)
Download
Models ( 5 )
Allele
Disease
Evidence
References
inferred from mutant phenotype
model of  cancer
in combination with pnutGD1512
model of  cancer
inferred from mutant phenotype
model of  ovarian cancer
inferred from mutant phenotype
Interactions ( 4 )
Comments ( 1 )
 
Expression of ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 in adult intestinal stem cells results in increased cell proliferation, leading to systemic organ wasting that affects the ovary, fat body and muscle.
Human Orthologs (via DIOPT v7.1)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please look at the Interaction Group reports for full details of the physical interactions
RNA-RNA
Interacting group
Assay
References
protein-protein
Interacting group
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
suppressible
suppressible
External Data
Subunit Structure (UniProtKB)
Interacts (via WW domains) with wts. Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd. The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta.
(UniProt, Q45VV3 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Pathways
Gene Group - Pathway Membership (FlyBase)
Hippo Signaling Pathway Core Components -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Activation of the Hippo pathway results in the down-regulation of cell proliferation and up-regulation of apoptosis, limiting tissue size. (Adapted from FBrf0224870).
External Data
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-106
Cytogenetic map
Sequence location
2R:24,065,975..24,068,485 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
60B7-60B8
Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (15)
Genomic Clones (16)
 
cDNA Clones (60)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: yki CG4005
Source for database merge of
Additional comments
Other Comments
yki promotes transcription by recruiting a histone methyltransferase complex.
The competitive properties of yki-expressing cells is extremely reduced when they are surrounded by cells expressing very high amounts of dm.
yki regulates expression of the ban miRNA.
yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Origin and Etymology
Discoverer
Etymology
This gene is named "yorkie" after Yorkshire Terriers, one of the World's smallest breeds of pet dogs, according to its loss-of-function phenotype.
Identification
External Crossreferences and Linkouts ( 52 )
Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Linkouts
BioGRID - A database of protein and genetic interactions.
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
FlyMine - An integrated database for Drosophila genomics
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Genes - Molecular building blocks of life in the genomic space.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Synonyms and Secondary IDs (10)
Reported As
Symbol Synonym
Yki
(Bae and Luo, 2018, Cong et al., 2018, Elbediwy and Thompson, 2018, Enomoto et al., 2018, Fulford et al., 2018, Gou et al., 2018, He et al., 2018, Kim and Jho, 2018, Martín and Morata, 2018, Perochon et al., 2018, Richardson and Portela, 2018, Shen et al., 2018, Simón-Carrasco et al., 2018, Tsuboi et al., 2018, Xu et al., 2018, Baker, 2017, Di Giacomo et al., 2017, Hariharan and Serras, 2017, Hu et al., 2017, Jang et al., 2017, Karaiskos et al., 2017, Li et al., 2017, Liu and Jin, 2017, Liu and Jin, 2017, Ma et al., 2017, Moeller et al., 2017, Pascual et al., 2017, Richardson and Portela, 2017, Shalaby et al., 2017, Shu and Deng, 2017, Song et al., 2017, Tue et al., 2017, Weide et al., 2017, Yamamoto et al., 2017, Zaytseva and Quinn, 2017, Zhang et al., 2017, Atkins et al., 2016, Becker et al., 2016, Fallahi et al., 2016, Hergovich, 2016, Hu et al., 2016, Jiang et al., 2016, Ko et al., 2016, Meng et al., 2016, Padash Barmchi et al., 2016, Saadin and Starz-Gaiano, 2016, Simon et al., 2016, Tamori et al., 2016, Viets et al., 2016, Yadav et al., 2016, Cao et al., 2015, Dent et al., 2015, Enomoto et al., 2015, Enomoto et al., 2015, Figueroa-Clarevega and Bilder, 2015, Gaspar et al., 2015, Grifoni and Bellosta, 2015, Grifoni et al., 2015, Irvine and Harvey, 2015, Morata and Ballesteros-Arias, 2015, Sopko et al., 2015, Su, 2015, Zheng et al., 2015, Amoyel and Bach, 2014, Bilak et al., 2014, Bossuyt et al., 2014, Cao et al., 2014, Chen et al., 2014, Hu et al., 2014, Ikmi et al., 2014, Qing et al., 2014, Robbins et al., 2014, Sadeqzadeh et al., 2014, Slattery et al., 2014, Andersen et al., 2013, Bausek, 2013, Degoutin et al., 2013, Enderle and McNeill, 2013, Gallant, 2013, Guo et al., 2013, Huang et al., 2013, Jin et al., 2013, Khan et al., 2013, Levayer and Moreno, 2013, Lucas et al., 2013, Matsui and Lai, 2013, Ren et al., 2013, Sidor et al., 2013, Slattery et al., 2013, Wong et al., 2013, Yin et al., 2013, Yu and Guan, 2013, Yu et al., 2013, Zoranovic et al., 2013, Amoyel and Bach, 2012, Chen et al., 2012, Fausti et al., 2012, Jin et al., 2012, Liu et al., 2012, Tokusumi et al., 2012, Worley et al., 2012, Yue et al., 2012, Baker, 2011, Chan et al., 2011, Genevet and Tapon, 2011, Gilbert et al., 2011, Halder and Johnson, 2011, Laprise, 2011, Oh and Irvine, 2011, Parker, 2011, Rauskolb et al., 2011, Richter et al., 2011, Salah and Aqeilan, 2011, Truscott et al., 2011, Zhang et al., 2011, Grzeschik et al., 2010, Hall et al., 2010, Ho et al., 2010, Ren et al., 2010, Yu et al., 2010, Hamaratoglu et al., 2009, Oh and Irvine, 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Rogulja et al., 2008, Shimizu et al., 2008, Zhai et al., 2008, Zhang et al., 2008, Zhang et al., 2008, Wei et al., 2007, Wei et al., 2007, Edgar, 2006, Hariharan, 2006, Polesello et al., 2006, Willecke et al., 2006)
yki
(Azuma et al., 2018, Billmann et al., 2018, Campbell et al., 2018, Gene Disruption Project members, 2018-, Gou et al., 2018, Li et al., 2018, Nyarko, 2018, Reilein et al., 2018, Tsai et al., 2018, Yu and Pan, 2018, Zülbahar et al., 2018, Hevia et al., 2017, Houtz et al., 2017, Katheder et al., 2017, Li et al., 2017, Ma et al., 2017, Moon et al., 2017, Rossi et al., 2017, Su et al., 2017, Upadhyay et al., 2017, Wells et al., 2017, Zhang et al., 2017, Boone et al., 2016, Chan et al., 2016, Corty et al., 2016, Deng et al., 2016, Harris et al., 2016, Huang et al., 2016, Jahanshahi et al., 2016, Liu et al., 2016, Losick et al., 2016, Mao et al., 2016, Moulton and Letsou, 2016, Park et al., 2016, Poon et al., 2016, Sakuma et al., 2016, Sarov et al., 2016, Suijkerbuijk et al., 2016, Willsey et al., 2016, Barrios et al., 2015, Dent et al., 2015, Di Cara et al., 2015, Dong et al., 2015, Enomoto et al., 2015, Enzo et al., 2015, Fletcher et al., 2015, Gailite et al., 2015, Keder et al., 2015, Kwon et al., 2015, Kwon et al., 2015, Li et al., 2015, Pasco et al., 2015, Sun et al., 2015, Wan et al., 2015, Wang and Baker, 2015, Wittkorn et al., 2015, Wong et al., 2015, Yu et al., 2015, Zaessinger et al., 2015, Zhang et al., 2015, Zhu et al., 2015, Boyle et al., 2014, Djabrayan et al., 2014, Ferguson and Martinez-Agosto, 2014, Fernández et al., 2014, Handke et al., 2014, Huang and Kalderon, 2014, Huang et al., 2014, Huang et al., 2014, Ikmi et al., 2014, Johnston, 2014, Li et al., 2014, Lin et al., 2014, Rauskolb et al., 2014, Rhee et al., 2014, Sing et al., 2014, Skwarek et al., 2014, Sorrentino et al., 2014, Tipping and Perrimon, 2014, Huang et al., 2013, Ilanges et al., 2013, Jukam et al., 2013, Jukam et al., 2013, Khan et al., 2013, Koontz et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Lin et al., 2013, Losick et al., 2013, Marcinkevicius and Zallen, 2013, Oh et al., 2013, Repiso et al., 2013, Tamori and Deng, 2013, Webber et al., 2013, Wehr et al., 2013, Yu et al., 2013, Yu et al., 2013, Zhang and Cohen, 2013, Zhou and Luo, 2013, Chen and Verheyen, 2012, Herranz et al., 2012, Kagey et al., 2012, Nagaraj et al., 2012, Poernbacher et al., 2012, Poon et al., 2012, Schoenherr et al., 2012, Verghese et al., 2012, Ye et al., 2012, Zhai et al., 2012, Zhang et al., 2012, Bao et al., 2011, Boggiano et al., 2011, Chen et al., 2011, Fernández et al., 2011, Gerhold et al., 2011, Gilbert et al., 2011, Grusche et al., 2011, Kawamori et al., 2011, Napoletano et al., 2011, Reddy and Irvine, 2011, Willecke et al., 2011, Zhang et al., 2011, Baumgartner et al., 2010, Baumgartner et al., 2010, Beam and Moberg, 2010, Benseñor et al., 2010, Chen et al., 2010, Das Thakur et al., 2010, Estella and Mann, 2010, Fang and Adler, 2010, Genevet et al., 2010, Genevet et al., 2010, Menéndez et al., 2010, Milton et al., 2010, Morrison and Halder, 2010, Neto-Silva et al., 2010, Nicolay et al., 2010, Reddy et al., 2010, Ren et al., 2010, Ribeiro et al., 2010, Robinson et al., 2010, Shaw et al., 2010, Varelas et al., 2010, Yu et al., 2010, Zecca and Struhl, 2010, Ziosi et al., 2010, Badouel et al., 2009, Genevet et al., 2009, Gilbert et al., 2009, Gilbert et al., 2009, Hamaratoglu et al., 2009, Peng et al., 2009, Zhang et al., 2009, Zhao et al., 2009, Baena-Lopez et al., 2008, Goulev et al., 2008, Nicolay and Frolov, 2008, Oh and Irvine, 2008, Sun et al., 2008, Wu et al., 2008, Yu et al., 2008, Zhao et al., 2008, Dong et al., 2007, Meignin et al., 2007, Polesello and Tapon, 2007, Shcherbata et al., 2007, Zhao et al., 2007, Bennett and Harvey, 2006, Cho et al., 2006, Emoto et al., 2006, Silva, 2006, Silva et al., 2006)
Name Synonyms
Yorkie
(Ahmed-de-Prado and Baonza, 2018, Gou et al., 2018, Kon, 2018, Moon et al., 2018, Di Giacomo et al., 2017, Liu et al., 2017, Upadhyay et al., 2017, Zaytseva and Quinn, 2017, Atkins et al., 2016, Becker et al., 2016, Boone et al., 2016, Chan et al., 2016, Corty et al., 2016, Hergovich, 2016, Hirabayashi, 2016, Ko et al., 2016, Hariharan, 2015, Kwon et al., 2015, Thompson, 2015, Wong et al., 2015, Zhu et al., 2015, Cao et al., 2014, Handke et al., 2014, Li et al., 2014, Robbins et al., 2014, Sadeqzadeh et al., 2014, Ayyaz and Jasper, 2013, Bausek, 2013, Huang et al., 2013, Jukam et al., 2013, Khan et al., 2013, Konsavage and Yochum, 2013, Kwon et al., 2013, Lawrence and Casal, 2013, Levayer and Moreno, 2013, Losick et al., 2013, Lucas et al., 2013, Repiso et al., 2013, Slattery et al., 2013, Yang and Hata, 2013, Zhou and Luo, 2013, Amoyel and Bach, 2012, Chen et al., 2012, Fausti et al., 2012, Jin et al., 2012, Mirth and Shingleton, 2012, Nagaraj et al., 2012, Schoenherr et al., 2012, Zhang et al., 2012, Bao et al., 2011, Halder and Johnson, 2011, Laprise, 2011, Poon et al., 2011, Reddy and Irvine, 2011, Baumgartner et al., 2010, Fang and Adler, 2010, Genevet et al., 2010, Grzeschik et al., 2010, Ho et al., 2010, Milton et al., 2010, Neto-Silva et al., 2010, Ren et al., 2010, Robinson et al., 2010, Varelas et al., 2010, Yu et al., 2010, Zecca and Struhl, 2010, Ziosi et al., 2010, Alarcón et al., 2009, Badouel et al., 2009, Hamaratoglu et al., 2009, Oh and Irvine, 2009, Oh et al., 2009, Zhang et al., 2009, Dutta and Baehrecke, 2008, Oh and Irvine, 2008, Zhang et al., 2008, Dong et al., 2007, Hamaratoglu et al., 2007, Meignin et al., 2007, Polesello and Tapon, 2007, Wei et al., 2007, Willecke et al., 2007, Cho et al., 2006, Colombani et al., 2006, Edgar, 2006, Hariharan, 2006, Polesello et al., 2006, Thompson and Cohen, 2006, Willecke et al., 2006)
Secondary FlyBase IDs
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • bait_protein
    Interaction map generated by purification of Hippo pathway factors, with identification of copurifying proteins by mass spectrometry.
    References (447)