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Gene Dmel\yki

General Information
Symbol	Dmel\yki	Species	D. melanogaster
Name	yorkie	Annotation symbol	CG4005
Feature type	protein_coding_gene	FlyBase ID	FBgn0034970
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60B7-60B8	Sequence location	2R:19,953,498..19,956,008 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene yorkie is referred to in FlyBase by the symbol Dmel\yki (CG4005, FBgn0034970). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transcription factor binding; transcription coactivator activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; cell proliferation; morphogenesis of an epithelial sheet; negative regulation of apoptosis; stem cell proliferation; cell competition in a multicellular organism; regulation of growth. 61 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; wing disc; larval inner optic anlage; larval outer optic anlage; follicle cell; wing; adherens junction. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: WW/Rsp5/WWP. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628461_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of yki. Gene sequence location is 2R:19953498..19956008.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 Gilbert et al., 2011, Dev. Cell 20(5): 700--712
FB2012_01	Controlled Vocabulary Terms nucleus positive regulation of transcription from RNA polymerase II promoter transcription factor binding cytoplasm Transgenic Constructs P{UAS-yki.S168A.RFP} Sequence features BKN45358 HFA04437 BKN29756 Alleles yki[P295S] yki[Y282N] yki[G347R] yki[E271K] yki[S168A.Scer\UAS.T:Disc\RFP] yki[R310X] yki[F351I] yki[P88L] References Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 Poon et al., 2011, Dev. Cell 21(5): 896--906 Benseñor et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7311--7316 Willecke et al., 2011, Oncogene 30(39): 4067--4074 Brás-Pereira et al., 2011, Commun. Integr. Biol. 4(5): 612--615 Doggett et al., 2011, BMC Dev. Biol. 11: 57
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60B7-60B8   Limits computationally determined from genome sequence between P{lacW}Phmk07623&P{lacW}tsrk05633 and P{EP}EP503
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\yki for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) yki-RD FBtr0290256  NM_138035   1369   343 yki-RF FBtr0290258  NM_001043103   1525   395 yki-RG FBtr0309372     1436   395
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein yki-PD   FBpp0288695   37.8   343   5.34     NP_611879   AAF47156 yki-PF   FBpp0288697   43.6   395   5.04     NP_001036568   ABI31113 yki-PG   FBpp0301274   43.6   395   5.04
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WW/Rsp5/WWP (IPR001202)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA735440   AE013599 AAF47156   AE013599 ABI31113   AI238115   AI258230   AI260337   AI260800   AI261158   AI293780   AI294940   AI455127   AI456831   AI518792   AI533129   AI533516   AY058506 AAL13735   BG641319   BI164163   BI166320   BI237372   BI240779   BI375399   BI481772   BI483114   BI486537   BI579172   BI632125   BI632129   BI632771   BI636692   BI639881   BT029961   BT029965   BT030171   CK132154   CK658433   CO267359   CO268595   CO313696   CO339201   CO341878   CZ488917   CZ488918   EC070860   EC070929   EC075751   EC194840   EC202129   EC202758   EC210523   EC242779   EC252958   EC255264   EL886742   GH942733   GH943385   GH948673   GH949810   GH950125   GH952663   GH958494   GH960302   GH976679   GH980464   GH982379
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0034970    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0034970 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0034970 expression level Developmental Stage   Expression Level embryo 00-02hr    4794 embryo 02-04hr    2030 embryo 04-06hr    3813 embryo 06-08hr    4318 embryo 08-10hr    3537 embryo 10-12hr    2953 embryo 12-14hr    2740 embryo 14-16hr    2002 embryo 16-18hr    1838 embryo 18-20hr    2110 embryo 20-22hr    1815 embryo 22-24hr    1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2    1584 larva L3 puffstage 3-6    2195 larva L3 puffstage 7-9    2674 white prepupae new    2924 white prepupae 12hr    2622 white prepupae 24hr    3337 pupae 2d postWPP    3378 pupae 3d postWPP    1917 pupae 4d postWPP    1546 adult male 01day    1845 adult male 05day    2485 adult male 30day    2411 adult female 01day    2193 adult female 05day    3203 adult female 30day    3464 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4794) embryo 02-04hr  (2030) embryo 04-06hr  (3813) embryo 06-08hr  (4318) embryo 08-10hr  (3537) embryo 10-12hr  (2953) embryo 12-14hr  (2740) embryo 14-16hr  (2002) embryo 16-18hr  (1838) embryo 18-20hr  (2110) embryo 20-22hr  (1815) embryo 22-24hr  (1667) larva L1  (1347) larva L2  (1213) larva L3 12hr old  (1101) larva L3 puffstage 1-2  (1584) larva L3 puffstage 3-6  (2195) larva L3 puffstage 7-9  (2674) white prepupae new  (2924) white prepupae 12hr  (2622) white prepupae 24hr  (3337) pupae 2d postWPP  (3378) pupae 3d postWPP  (1917) pupae 4d postWPP  (1546) adult male 01day  (1845) adult male 05day  (2485) adult male 30day  (2411) adult female 01day  (2193) adult female 05day  (3203) adult female 30day  (3464) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4794) embryo 02-04hr  (2030) embryo 04-06hr  (3813) embryo 06-08hr  (4318) embryo 08-10hr  (3537) embryo 10-12hr  (2953) embryo 12-14hr  (2740) embryo 14-16hr  (2002) embryo 16-18hr  (1838) embryo 18-20hr  (2110) embryo 20-22hr  (1815) embryo 22-24hr  (1667) larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2  (1584) larva L3 puffstage 3-6  (2195) larva L3 puffstage 7-9  (2674) white prepupae new  (2924) white prepupae 12hr  (2622) white prepupae 24hr  (3337) pupae 2d postWPP  (3378) pupae 3d postWPP  (1917) pupae 4d postWPP  (1546) adult male 01day  (1845) adult male 05day  (2485) adult male 30day  (2411) adult female 01day  (2193) adult female 05day  (3203) adult female 30day  (3464) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4794 embryo 02-04hr    2030 embryo 04-06hr    3813 embryo 06-08hr    4318 embryo 08-10hr    3537 embryo 10-12hr    2953 embryo 12-14hr    2740 embryo 14-16hr    2002 embryo 16-18hr    1838 embryo 18-20hr    2110 embryo 20-22hr    1815 embryo 22-24hr    1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2    1584 larva L3 puffstage 3-6    2195 larva L3 puffstage 7-9    2674 white prepupae new    2924 white prepupae 12hr    2622 white prepupae 24hr    3337 pupae 2d postWPP    3378 pupae 3d postWPP    1917 pupae 4d postWPP    1546 adult male 01day    1845 adult male 05day    2485 adult male 30day    2411 adult female 01day    2193 adult female 05day    3203 adult female 30day    3464 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4794 embryo 02-04hr    2030 embryo 04-06hr    3813 embryo 06-08hr    4318 embryo 08-10hr    3537 embryo 10-12hr    2953 embryo 12-14hr    2740 embryo 14-16hr    2002 embryo 16-18hr    1838 embryo 18-20hr    2110 embryo 20-22hr    1815 embryo 22-24hr    1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2    1584 larva L3 puffstage 3-6    2195 larva L3 puffstage 7-9    2674 white prepupae new    2924 white prepupae 12hr    2622 white prepupae 24hr    3337 pupae 2d postWPP    3378 pupae 3d postWPP    1917 pupae 4d postWPP    1546 adult male 01day    1845 adult male 05day    2485 adult male 30day    2411 adult female 01day    2193 adult female 05day    3203 adult female 30day    3464 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0034970 expression level Developmental Stage   Expression Level embryo 00-02hr    4794 embryo 02-04hr    2030 embryo 04-06hr    3813 embryo 06-08hr    4318 embryo 08-10hr    3537 embryo 10-12hr    2953 embryo 12-14hr    2740 embryo 14-16hr    2002 embryo 16-18hr    1838 embryo 18-20hr    2110 embryo 20-22hr    1815 embryo 22-24hr    1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2    1584 larva L3 puffstage 3-6    2195 larva L3 puffstage 7-9    2674 white prepupae new    2924 white prepupae 12hr    2622 white prepupae 24hr    3337 pupae 2d postWPP    3378 pupae 3d postWPP    1917 pupae 4d postWPP    1546 adult male 01day    1845 adult male 05day    2485 adult male 30day    2411 adult female 01day    2193 adult female 05day    3203 adult female 30day    3464 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4794) embryo 02-04hr  (2030) embryo 04-06hr  (3813) embryo 06-08hr  (4318) embryo 08-10hr  (3537) embryo 10-12hr  (2953) embryo 12-14hr  (2740) embryo 14-16hr  (2002) embryo 16-18hr  (1838) embryo 18-20hr  (2110) embryo 20-22hr  (1815) embryo 22-24hr  (1667) larva L1  (1347) larva L2  (1213) larva L3 12hr old  (1101) larva L3 puffstage 1-2  (1584) larva L3 puffstage 3-6  (2195) larva L3 puffstage 7-9  (2674) white prepupae new  (2924) white prepupae 12hr  (2622) white prepupae 24hr  (3337) pupae 2d postWPP  (3378) pupae 3d postWPP  (1917) pupae 4d postWPP  (1546) adult male 01day  (1845) adult male 05day  (2485) adult male 30day  (2411) adult female 01day  (2193) adult female 05day  (3203) adult female 30day  (3464) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4794) embryo 02-04hr  2030 embryo 04-06hr  (3813) embryo 06-08hr  (4318) embryo 08-10hr  (3537) embryo 10-12hr  (2953) embryo 12-14hr  (2740) embryo 14-16hr  2002 embryo 16-18hr  1838 embryo 18-20hr  2110 embryo 20-22hr  1815 embryo 22-24hr  1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2  1584 larva L3 puffstage 3-6  2195 larva L3 puffstage 7-9  (2674) white prepupae new  (2924) white prepupae 12hr  (2622) white prepupae 24hr  (3337) pupae 2d postWPP  (3378) pupae 3d postWPP  1917 pupae 4d postWPP  1546 adult male 01day  1845 adult male 05day  (2485) adult male 30day  2411 adult female 01day  2193 adult female 05day  (3203) adult female 30day  (3464) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4794 embryo 02-04hr    2030 embryo 04-06hr    3813 embryo 06-08hr    4318 embryo 08-10hr    3537 embryo 10-12hr    2953 embryo 12-14hr    2740 embryo 14-16hr    2002 embryo 16-18hr    1838 embryo 18-20hr    2110 embryo 20-22hr    1815 embryo 22-24hr    1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2    1584 larva L3 puffstage 3-6    2195 larva L3 puffstage 7-9    2674 white prepupae new    2924 white prepupae 12hr    2622 white prepupae 24hr    3337 pupae 2d postWPP    3378 pupae 3d postWPP    1917 pupae 4d postWPP    1546 adult male 01day    1845 adult male 05day    2485 adult male 30day    2411 adult female 01day    2193 adult female 05day    3203 adult female 30day    3464 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4794 embryo 02-04hr    2030 embryo 04-06hr    3813 embryo 06-08hr    4318 embryo 08-10hr    3537 embryo 10-12hr    2953 embryo 12-14hr    2740 embryo 14-16hr    2002 embryo 16-18hr    1838 embryo 18-20hr    2110 embryo 20-22hr    1815 embryo 22-24hr    1667 larva L1    1347 larva L2    1213 larva L3 12hr old    1101 larva L3 puffstage 1-2    1584 larva L3 puffstage 3-6    2195 larva L3 puffstage 7-9    2674 white prepupae new    2924 white prepupae 12hr    2622 white prepupae 24hr    3337 pupae 2d postWPP    3378 pupae 3d postWPP    1917 pupae 4d postWPP    1546 adult male 01day    1845 adult male 05day    2485 adult male 30day    2411 adult female 01day    2193 adult female 05day    3203 adult female 30day    3464 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0034970    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0034970 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult salivary gland, larval trachea, adult ovary, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0034970 expression level Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0034970 expression level Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    155.35 Larval Midgut    176.5 Larval Hindgut    199.6 Larval Malpighian Tubules    351.1 Larval Fat Body    96.5 Larval Salivary Gland    252.6 Larval Trachea    302.4 Larval Carcass    187.525 Adult Head    177.3 Adult Eye    139.225 Adult Brain    341.1 Adult Thoracic-Abdominal Ganglion    281.4 Adult Crop    270.8 Adult Midgut    182.9 Adult Hindgut    233.1 Adult Malpighian Tubules    376.4 Adult Fat Body    64.3 Adult Salivary Gland    330.7 Adult Heart    102.55 Adult VirginFemale Spermatheca    91.1 Adult InseminatedFemale Spermatheca    99.7 Adult Ovary    361 Adult Testis    202.9 Adult Male Accessory Gland    186.3 Adult Carcass    120.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    177.3   NA  Eye    139.225   NA  Brain    341.1   155.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    281.4   NA  Crop    270.8   176.5  Midgut    182.9   199.6  Hindgut    233.1   351.1  Malpighian Tubules    376.4   96.5  Fat Body    64.3   252.6  Salivary Gland    330.7   NA  Heart    102.55   302.4  Trachea    NA   NA  VirginFemale Spermatheca    91.1   NA  InseminatedFemale Spermatheca    99.7   NA  Ovary    361   NA  Testis    202.9   NA  Male Accessory Gland    186.3   187.525  Carcass    120.2 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034970 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4005-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for yki Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone ykiΔ.w lethal ykiB5 lethal, with Scer\GAL4GMR.PF ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 lethal, with Scer\GAL4vg.PM ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 lethal (with ykiB5) ykiE271K ykiF351I ykiG347R ykiP88L ykiP295S ykiR310X ykiY282N lethal (with ykiE271K) ykiB5 lethal (with ykiF351I) ykiB5 lethal (with ykiG347R) ykiB5 lethal (with ykiP88L) ykiB5 lethal (with ykiP295S) ykiB5 lethal (with ykiR310X) ykiB5 lethal (with ykiY282N) ykiB5 lethal | embryonic stage ykiΔ.w lethal | first instar larval stage ykiΔ.w lethal | larval stage, with Scer\GAL4sd-SG29.1 ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 lethal | partially, with Scer\GAL4GMR.PF ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 lethal | partially, with Scer\GAL4sd-SG29.1 ykiS111A.S250A.Scer\UAS.T:SV5\V5 lethal | pupal stage, with Scer\GAL4pnr-MD237 ykiGD11187 lethal | somatic clone ykiS168A.αTub84B Other Phenotypes Allele cell shape defective | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa cell shape defective | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa cell size defective | somatic clone ykiB5 decreased cell death | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa hyperplasia | somatic clone ykiS168A.αTub84B hyperplasia | somatic clone, with Scer\GAL4αTub84B.PP ykiScer\UAS.cHa increased cell number, with Scer\GAL4C5 ykiS97A.Scer\UAS ykiScer\UAS.T:SV5\V5 ykiW1W2.Scer\UAS increased cell number, with Scer\GAL4Scer\FRT.Act5C ykiScer\UAS.T:SV5\V5 ykiW1W2.Scer\UAS increased cell number | somatic clone, with Scer\GAL4esg-NP5130 ykiScer\UAS.cZa increased cell number | somatic clone, with Scer\GAL4Myo31DF-NP0001, Scer\GAL80ts.αTub84B ykiScer\UAS.cZa increased cell number | somatic clone, with Scer\GAL4αTub84B.PL ykiScer\UAS.cHa increased cell size | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa increased cell size | somatic clone, with Scer\GAL4αTub84B.PP ykiScer\UAS.cHa mitotic cell cycle defective | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa mitotic cell cycle defective | somatic clone, with Scer\GAL4esg-NP5130 ykiScer\UAS.cZa mitotic cell cycle defective | somatic clone, with Scer\GAL4Myo31DF-NP0001, Scer\GAL80ts.αTub84B ykiScer\UAS.cZa neuroanatomy defective | larval stage, with Scer\GAL4C855a ykiS168A.Scer\UAS.T:Disc\RFP size defective, with Scer\GAL4GMR.PF ykiScer\UAS.cHa size defective, with Scer\GAL4hh-Gal4 ykiScer\UAS.cHa size defective | larval stage, with Scer\GAL4GMR.PFa ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 tumorigenic, with Scer\GAL4Act5C.PI ykiS168A.Scer\UAS.T:SV5\V5 visible, with Scer\GAL4ey.PH ykidsRNA.C.Scer\UAS ykidsRNA.N.Scer\UAS visible, with Scer\GAL4GMR.PF yki3SA.Scer\UAS.cRa.T:Hsap\MYC ykiM1.Scer\UAS.T:Hsap\MYC ykiM12.Scer\UAS.T:Hsap\MYC ykiM123.Scer\UAS.T:Hsap\MYC ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.cRa.T:Hsap\MYC ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.cRa.T:Hsap\MYC ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiS168A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 ykiScer\UAS.cHa ykiScer\UAS.cRa.T:Hsap\MYC ykiScer\UAS.cZa ykiScer\UAS.T:Hsap\MYC ykiScer\UAS.T:SV5\V5 visible, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 visible, with Scer\GAL4sd-SG29.1 ykiS111A.S168A.S250A-WW.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 visible | somatic clone, with Scer\GAL4tub.PU ykiM123.Scer\UAS.T:Hsap\MYC Phenotype manifest in Allele adherens junction, with Scer\GAL4en-e16E ykiScer\UAS.cHa adult cuticle | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa adult head | somatic clone ykiS168A.αTub84B epithelial cell | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa eye ykiΔ.w eye, with Scer\GAL4ey.PH ykidsRNA.N.Scer\UAS ykidsRNA.C.Scer\UAS eye, with Scer\GAL4GMR.PF ykiScer\UAS.T:Hsap\MYC ykiScer\UAS.cZa ykiM1.Scer\UAS.T:Hsap\MYC ykiM12.Scer\UAS.T:Hsap\MYC ykiM123.Scer\UAS.T:Hsap\MYC ykiScer\UAS.cHa ykiScer\UAS.cRa.T:Hsap\MYC ykiS168A.Scer\UAS.cRa.T:Hsap\MYC ykiS111A.S250A.Scer\UAS.cRa.T:Hsap\MYC yki3SA.Scer\UAS.cRa.T:Hsap\MYC ykiScer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiS250A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 ykiS168A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.Scer\UAS.T:SV5\V5 ykiS168A.S250A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 eye, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL ykiS168A.Scer\UAS.T:SV5\V5 ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 eye | pupal stage | somatic clone, with Scer\GAL4αTub84B.PL ykiScer\UAS.cHa eye | somatic clone ykiS168A.αTub84B eye | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiW1W2.Scer\UAS ykiScer\UAS.T:SV5\V5 eye | somatic clone, with Scer\GAL4tub.PU ykiM123.Scer\UAS.T:Hsap\MYC eye disc, with Scer\GAL4GMR.PF ykiScer\UAS.cZa eye disc | larval stage, with Scer\GAL4GMR.PFa ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 eye disc | somatic clone ykiB5 ykiS168A.αTub84B eye disc | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa eye disc | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa follicle cell, with Scer\GAL4Act5C.PI ykiS168A.Scer\UAS.T:SV5\V5 haltere | somatic clone ykiS168A.αTub84B interommatidial bristle | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiScer\UAS.T:SV5\V5 interommatidial bristle | supernumerary, with Scer\GAL4GMR.PF ykiScer\UAS.cHa intestinal stem cell | somatic clone, with Scer\GAL4esg-NP5130 ykiScer\UAS.cZa intestinal stem cell | somatic clone, with Scer\GAL4Myo31DF-NP0001, Scer\GAL80ts.αTub84B ykiScer\UAS.cZa larval inner optic anlage, with Scer\GAL4C855a ykiS168A.Scer\UAS.T:Disc\RFP larval outer optic anlage, with Scer\GAL4C855a ykiS168A.Scer\UAS.T:Disc\RFP leg | somatic clone ykiS168A.αTub84B mesothoracic tergum | somatic clone ykiS168A.αTub84B pigment cell | supernumerary, with Scer\GAL4GMR.PF ykiScer\UAS.cHa wing, with Scer\GAL4C5 ykiW1W2.Scer\UAS ykiS97A.Scer\UAS ykiScer\UAS.T:SV5\V5 wing, with Scer\GAL4sd-SG29.1 ykiS111A.Scer\UAS.T:SV5\V5 ykiS250A.Scer\UAS.T:SV5\V5 ykiS169D.S172D.Scer\UAS.T:SV5\V5 ykiS111A.S168A.S250A-WW.Scer\UAS.T:SV5\V5 ykiS111A.S250A.Scer\UAS.T:SV5\V5 wing | somatic clone ykiS168A.αTub84B wing | somatic clone, with Scer\GAL4Scer\FRT.Act5C ykiW1W2.Scer\UAS ykiScer\UAS.T:SV5\V5 wing disc, with Scer\GAL4hh-Gal4 ykiScer\UAS.cHa wing disc | cell autonomous | somatic clone ykiB5 wing disc | cell autonomous | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa wing disc | cell non-autonomous | somatic clone ykiB5 wing disc | cell non-autonomous | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa wing disc | posterior compartment, with Scer\GAL4hh-Gal4 ykiScer\UAS.cZa wing disc | somatic clone ykiB5 wing disc | somatic clone, with Scer\GAL4Act5C.PI ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 ykiS111A.S250A.Scer\UAS.T:SV5\V5 wing disc | somatic clone, with Scer\GAL4Act5C.PP ykiScer\UAS.cHa wing disc | somatic clone, with Scer\GAL4tub.PU ykiScer\UAS.cHa wing disc | third instar larval stage ykiΔ.w
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of yki Class Mutagen Stocks Known lesion ykiB5 loss of function allele 1 -- ykif06249 piggyBac transposase 1 -- ykiMB09079 1 -- ykiDbo1 0 Yes ykiDbo2 0 Yes ykiDbo3 0 Yes ykiE271K ethyl methanesulfonate 0 Yes ykiF351I ethyl methanesulfonate 0 Yes ykiG347R ethyl methanesulfonate 0 Yes ykiP295S ethyl methanesulfonate 0 Yes ykiP88L ethyl methanesulfonate 0 Yes ykiR310X ethyl methanesulfonate 0 Yes ykiY282N ethyl methanesulfonate 0 Yes ykiΔ.w recombination SCEI endonuclease FLPase 0 Yes
Alleles Carried on Transgenic Constructs ( 47 )
For All Alleles Carried on Transgenic Constructs Show
Allele of yki Class Mutagen Stocks Known lesion ykiS168A.Scer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes ykiGD11187 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiHMS00041 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiJF03119 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiKK109756 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ykiS111A.S168A.S250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes ykiS168A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 1 Yes ykiScer\UAS.cOa.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes ykiScer\UAS.T:Avic\GFP-EGFP,T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes yki-WW.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes yki1-418.T:Scer\GAL4 in vitro construct - regulatory fusion 0 Yes yki3SA.Scer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykidsRNA.C.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ykidsRNA.N.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ykiGMR.PH in vitro construct - regulatory fusion 0 Yes ykiM1.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM12.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM123.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM2.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiM3.Scer\UAS.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes ykiNIG.4005R in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes ykiS111A.S168A.S250A-WW.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.S168A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.S250A.Scer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.S250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS111A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.S250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\FRT.αTub84B in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS168A.αTub84B FLPase 0 Yes ykiS169A.S172A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS169D.S172D.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS250A.Scer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes ykiS97A.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes ykiScer\FRT.D.αTub84B in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.cRa.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.cZa in vitro construct - regulatory fusion 0 Yes ykiScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiScer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiw.Scer\SceI.RS in vitro construct 0 Yes ykiW1W2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes ykiαTub84B.PD FLPase 0 Yes ykiαTub84B.PH in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6081 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-Myc-yki.3SA} NA M{UAS-Myc-yki.S111A.S250A} NA M{UAS-Myc-yki.S168A} NA M{UAS-Myc-yki} NA P{GD11187} NA P{KK109756} NA P{TRiP.HMS00041} NA P{TRiP.JF03119} NA P{UAS-yki.Fg} NA P{UAS-yki.GFP} NA P{UAS-yki.M1.Myc} NA P{UAS-yki.M2.Myc} NA P{UAS-yki.M3.Myc} NA P{UAS-yki.M12.Myc} NA P{UAS-yki.M123.Myc} NA P{UAS-yki.Myc} NA P{UAS-yki.RNAi.C} NA P{UAS-yki.RNAi.N} NA P{UAS-yki.S97A} NA P{UAS-yki.S111A.S168A.S250A.V5} NA P{UAS-yki.S111A.S168A.S250A-WW.V5} NA P{UAS-yki.S111A.S168A.V5} NA P{UAS-yki.S111A.S250A.V5} NA P{UAS-yki.S111A.V5} NA P{UAS-yki.S168A.GFP} NA P{UAS-yki.S168A.RFP} NA P{UAS-yki.S168A.S250A.V5} NA P{UAS-yki.S168A.V5} NA P{UAS-yki.S169A.S172A.V5} NA P{UAS-yki.S169D.S172D.V5} NA P{UAS-yki.S250A.V5} NA P{UAS-yki.V5.O} NA P{UAS-yki.V5} NA P{UAS-yki.W1W2} NA P{UAS-yki.-WW.V5} NA P{UAS-yki.Z} NA P{UAS-yki} NA characterization construct P{FRT(yki.Scer\SceI.RS)} NA P{NIG.4005R} NA P{tub(FRT.y+)yki.D} NA P{tub(FRT.y+)yki.S168A} NA P{tub(-FRT)yki.D} NA P{tub(-FRT)yki.S168A} NA P{tub-yki.H} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}ykif06249 NA insertion of enhancer trap binary system Mi{ET1}ykiMB09079 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
transcription coactivator activity inferred from direct assay (Goulev et al., 2008) transcription factor binding inferred from physical interaction with sd (Goulev et al., 2008)
Biological Process
CV term Evidence References
cell competition in a multicellular organism inferred from mutant phenotype (Ziosi et al., 2010) cell proliferation inferred from mutant phenotype (Huang et al., 2005, Thompson and Cohen, 2006) morphogenesis of an epithelial sheet inferred from mutant phenotype (Thompson and Cohen, 2006) negative regulation of apoptosis inferred from mutant phenotype (Huang et al., 2005, Thompson and Cohen, 2006) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Goulev et al., 2008) regulation of growth inferred from mutant phenotype (Nolo et al., 2006) stem cell proliferation inferred from direct assay (Ren et al., 2010)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Goulev et al., 2008) nucleus inferred from direct assay (Goulev et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transcription coactivator activity non-traceable author statement (Jukam et al., 2006) ubiquitin-protein ligase activity inferred from sequence or structural similarity with Saccharomyces RSP5 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of rhodopsin gene expression non-traceable author statement (Jukam et al., 2006)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions yki allele Gene References unspecified ban (Thompson and Cohen, 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63430 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034970 DroID - A comprehensive database of gene and protein interactions. • FBgn0034970 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37851
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13481 Dere\GG19955 Dgri\GH20170 Dmoj\GI18856 Dper\GL10424 Dpse\GA17846 Dsec\GM18275 Dsim\GD24973 Dvir\GJ20440 Dwil\GK21386 Dyak\GE11487
Curated drosophilid orthologs	Dpse\GA17846
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12840 NV15294 LH21476 ISCW009073 ISCW007670 FBgn0229292 FBgn0223378 FBgn0207580 FBgn0196286 FBgn0173182 JGI_V11_328360 FBgn0077855 FBgn0148034 FBgn0141595 FBgn0127634 FBgn0112155 FBgn0090510 CPIJ000291 CPIJ000289 BGIBMGA003682 BGIBMGA003681 ACYPI003364 GB19837 AGAP006045 AAEL015564 AAEL014022 AAEL014018 PHUM613740 GLEAN_04769
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	28819 w*; P{UAS-yki.V5.O}attP2 36290 l(2)gl4 ykiB5/CyO 28818 w*; P{UAS-yki.S168A.V5}attP2 28815 y1 w*; P{UAS-yki.GFP}4-12-1 34067 y1 v1; P{TRiP.HMS00041}attP2 26142 w1118; Mi{ET1}ykiMB09079/SM6a 28817 w*; P{UAS-yki.S111A.S168A.S250A.V5}attP2 28816 y1 w*; P{UAS-yki.S168A.GFP}10-7-Y 28836 y1 w*; P{UAS-yki.S168A.GFP}10-12-1
Harvard	- PBac{WH}ykif06249
VDRC	v104523 P{KK109756}VIE-260B v40497 w1118; P{GD11187}v40497/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR27M17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21311
Other clones	DPiM_LD21311 IP17673 IP17773 IP17873
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14114 LD36972 LD38548 LP01119 LP01370 LP04136 LP04779 LP06995 LP08432 LP13453 LP15346 RE03771 RE06409 RE33590 RE37695 RE63188 RE64373 RE65955 RE69979 RE73160 SD04845 SD05370 SD12639 SD18481 SD22581 SD25726 SD25730 SD26638
Other clones	37662 81313 99988 107884 214443.75 214443.76 CK01.23B.B2 CK01.108A.C3 CK01.109C.D9 EK092110 EK149546 EK233751 EP01054 EP13331 IP17973 RP004032009 RP004140424 RP004176597 RP004180677 RP004194912 RP004222528 RP004241324 RP004251316 RP004256053 RP004312853 RP004546646
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0034970 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37851
Antibody Information
	polyclonal (Oh and Irvine, 2008)
Other Information
Discoverer
Etymology
	This gene is named "yorkie" after Yorkshire Terriers, one of the World's smallest breeds of pet dogs, according to its loss-of-function phenotype. (Huang et al., 2005)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: yki CG4005 (Jukam, 2006.3.1) Source for identity of: yki CG4005 (Huang et al., 2005)
Source for database merge of
Additional comments
Other Comments
	The competitive properties of yki-expressing cells is extremely reduced when they are surrounded by cells expressing very high amounts of dm. (Ziosi et al., 2010) yki regulates expression of the ban miRNA. (Nolo et al., 2006) yki is a kinase substrate of wts, becoming phosphorylated by wts upon activation of the hpo pathway. (Huang et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_138035 NM_001043103 RefSeq (Proteins) • NP_611879 NP_001036568 DDBJ / EMBL / GenBank • AA735440 AAF47156 AAL13735 ABI31113 AI455127 AY058506 CZ488917 CZ488918 Entrez Gene - A searchable database of RefSeq genes. • 37851
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WW/Rsp5/WWP (IPR001202)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63430 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0034970 DroID - A comprehensive database of gene and protein interactions. • FBgn0034970 DRSC - Results from RNAi screens. • FBgn0034970 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0034970 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4005-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0034970 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37851 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/yorkie1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37851 modMine - Data generated by the modENCODE project. • FBgn0034970 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12840 NV15294 LH21476 ISCW009073 ISCW007670 FBgn0229292 FBgn0223378 FBgn0207580 FBgn0196286 FBgn0173182 JGI_V11_328360 FBgn0077855 FBgn0148034 FBgn0141595 FBgn0127634 FBgn0112155 FBgn0090510 CPIJ000291 CPIJ000289 BGIBMGA003682 BGIBMGA003681 ACYPI003364 GB19837 AGAP006045 AAEL015564 AAEL014022 AAEL014018 PHUM613740 GLEAN_04769
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG4005 (Robertson, 2001.5.6, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) yap (Bennett and Harvey, 2006) Yki (Richter et al., 2011, Wei et al., 2007, Edgar, 2006, Shimizu et al., 2008, Truscott et al., 2011, Polesello et al., 2006, Hariharan, 2006, Wei et al., 2007, Zhang et al., 2008, Rogulja et al., 2008, Dutta and Baehrecke, 2008, Oh and Irvine, 2009, Hamaratoglu et al., 2009, Zhang et al., 2009, Zhang et al., 2008, Willecke et al., 2006, Grzeschik et al., 2010, Ren et al., 2010, Ho et al., 2010, Yu et al., 2010, Hall et al., 2010, Rauskolb et al., 2011, Gilbert et al., 2011) yki (Morrison and Halder, 2010, Silva et al., 2006, Bennett and Harvey, 2006, Yu et al., 2008, Dong et al., 2007, Silva, 2006, Fernández et al., 2011, Zhao et al., 2007, Sun et al., 2008, Nicolay and Frolov, 2008, Emoto et al., 2006, Wu et al., 2008, Oh and Irvine, 2008, Polesello and Tapon, 2007, Meignin et al., 2007, Goulev et al., 2008, Zhao et al., 2008, Badouel et al., 2009, Zhao et al., 2009, Hamaratoglu et al., 2009, Peng et al., 2009, Baena-Lopez et al., 2008, Cho et al., 2006, Gilbert et al., 2009, Gilbert et al., 2009, Zhang et al., 2009, Das Thakur et al., 2010, Robinson et al., 2010, Fang and Adler, 2010, Genevet et al., 2009, Yu et al., 2010, Baumgartner et al., 2010, Varelas et al., 2010, Genevet et al., 2010, Zecca and Struhl, 2010, Baumgartner et al., 2010, Beam and Moberg, 2010, Genevet et al., 2010, Ribeiro et al., 2010, Menéndez et al., 2010, Chen et al., 2010, Milton et al., 2010, Reddy et al., 2010, Nicolay et al., 2010, Ziosi et al., 2010, Neto-Silva et al., 2010, Grusche et al., 2011, Ren et al., 2010, Benseñor et al., 2010, Gilbert et al., 2011) YKI (Zeng et al., 2010)
Name Synonym	yorkie (Huang et al., 2005, Jukam, 2006.3.1, Jukam et al., 2006, Nolo et al., 2006, Jukam and Desplan, 2007, Morrison and Halder, 2010, Bennett and Harvey, 2006, Sun et al., 2008, Huang et al., 2008, Goulev et al., 2008, Peng et al., 2009, Zhang et al., 2009, Das Thakur et al., 2010, Fang and Adler, 2010, Menéndez et al., 2010, Chen et al., 2010, Reddy et al., 2010, Zeng et al., 2010, Benseñor et al., 2010) Yorkie (Wei et al., 2007, Thompson and Cohen, 2006, Edgar, 2006, Colombani et al., 2006, Hamaratoglu et al., 2007, Willecke et al., 2007, Dong et al., 2007, Polesello et al., 2006, Hariharan, 2006, Zhang et al., 2008, Oh and Irvine, 2008, Polesello and Tapon, 2007, Meignin et al., 2007, Dutta and Baehrecke, 2008, Badouel et al., 2009, Oh and Irvine, 2009, Hamaratoglu et al., 2009, Zhang et al., 2009, Cho et al., 2006, Willecke et al., 2006, Grzeschik et al., 2010, Robinson et al., 2010, Ren et al., 2010, Ho et al., 2010, Yu et al., 2010, Baumgartner et al., 2010, Varelas et al., 2010, Genevet et al., 2010, Zecca and Struhl, 2010, Fang and Adler, 2010, Milton et al., 2010, Ziosi et al., 2010, Neto-Silva et al., 2010)
Secondary FlyBase IDs
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 80 ) Supplementary material  ( 10 ) Review  ( 3 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 2 )
Recent research papers ( 43 )
	Brás-Pereira et al., 2011, Commun. Integr. Biol. 4(5): 612--615 Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway. [FBrf0216670] Doggett et al., 2011, BMC Dev. Biol. 11: 57 Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. [FBrf0216618] Fernández et al., 2011, Development 138(11): 2337--2346 Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. [FBrf0213674] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Jezowska et al., 2011, Dev. Biol. 360(1): 143--159 A dual function of Drosophila capping protein on DE-cadherin maintains epithelial integrity and prevents JNK-mediated apoptosis. [FBrf0216680] Napoletano et al., 2011, EMBO J. 30(5): 945--958 Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. [FBrf0213147] Nicolay et al., 2011, Genes Dev. 25(4): 323--335 Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. [FBrf0214348] Oh and Irvine, 2011, Dev. Cell 20(1): 109--122 Cooperative Regulation of Growth by Yorkie and Mad through bantam. [FBrf0212763] Poon et al., 2011, Dev. Cell 21(5): 896--906 The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway. [FBrf0216620] Rauskolb et al., 2011, PLoS Biol. 9(6): e1000624 Zyxin links fat signaling to the hippo pathway. [FBrf0213900] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sansores-Garcia et al., 2011, EMBO J. 30(12): 2325--2335 Modulating F-actin organization induces organ growth by affecting the Hippo pathway. [FBrf0213953] Sun and Irvine, 2011, Dev. Biol. 350(1): 139--151 Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. [FBrf0212753] Truscott et al., 2011, Genes Dev. 25(17): 1820--1834 mir-11 limits the proapoptotic function of its host gene, dE2f1. [FBrf0215211] Willecke et al., 2011, Oncogene 30(39): 4067--4074 Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. [FBrf0216281] Baumgartner et al., 2010, Dev. Cell 18(2): 309--316 The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila. [FBrf0210061] Beam and Moberg, 2010, Fly 4(2): 104--116 The gang of four gene regulates growth and patterning of the developing Drosophila eye. [FBrf0211089] Benseñor et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(16): 7311--7316 Microtubule-mediated transport of the tumor-suppressor protein Merlin and its mutants. [FBrf0214876] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15810--15815 The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. [FBrf0211766] Das Thakur et al., 2010, Curr. Biol. 20(7): 657--662 Ajuba LIM proteins are negative regulators of the Hippo signaling pathway. [FBrf0210592] Fang and Adler, 2010, Dev. Biol. 341(2): 360--374 Regulation of cell shape, wing hair initiation and the actin cytoskeleton by Trc/Fry and Wts/Mats complexes. [FBrf0210701] Genevet et al., 2010, Dev. Cell 18(2): 300--308 Kibra is a regulator of the Salvador/Warts/Hippo signaling network. [FBrf0211094] Grzeschik et al., 2010, Curr. Biol. 20(7): 573--581 Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. [FBrf0210559] Hall et al., 2010, Cancer Res. 70(21): 8517--8525 Hippo pathway effector Yap is an ovarian cancer oncogene. [FBrf0212244] Ho et al., 2010, Dev. Biol. 337(2): 274--283 Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. [FBrf0209794] Karpowicz et al., 2010, Development 137(24): 4135--4145 The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. [FBrf0212383] Menéndez et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14651--14656 A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway. [FBrf0211593] Milton et al., 2010, Development 137(5): 735--743 Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. [FBrf0209966] Morrison and Halder, 2010, genesis 48(1): 3--7 Characterization of a Dorsal-Eye Gal4 Line in Drosophila. [FBrf0209713] Neto-Silva et al., 2010, Dev. Cell 19(4): 507--520 Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap. [FBrf0212043] Nicolay et al., 2010, PLoS Genet. 6(4): e1000918 Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. [FBrf0210644] Reddy et al., 2010, Development 137(14): 2397--2408 Influence of fat-hippo and notch signaling on the proliferation and differentiation of Drosophila optic neuroepithelia. [FBrf0211109] Ren et al., 2010, Dev. Biol. 337(2): 303--312 Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. [FBrf0209792] Ren et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(49): 21064--21069 Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. [FBrf0212502] Ribeiro et al., 2010, Mol. Cell 39(4): 521--534 Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling. [FBrf0211636] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Staley and Irvine, 2010, Curr. Biol. 20(17): 1580--1587 Warts and yorkie mediate intestinal regeneration by influencing stem cell proliferation. [FBrf0211781] Varelas et al., 2010, Dev. Cell 18(4): 579--591 The Hippo pathway regulates Wnt/beta-catenin signaling. [FBrf0210631] Yu et al., 2010, Dev. Cell 18(2): 288--299 Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded. [FBrf0210017] Zecca and Struhl, 2010, PLoS Biol. 8(6): e1000386 A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. [FBrf0210985] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Ziosi et al., 2010, PLoS Genet. 6(9): dMyc Functions Downstream of Yorkie to Promote the Supercompetitive Behavior of Hippo Pathway Mutant Cells. [FBrf0211944] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...