FB2021_06, released December 14, 2021

Gene: Dmel\enok

Open Close
General Information
Symbol
Dmel\enok
Species
D. melanogaster
Name
enoki mushroom
Annotation Symbol
CG11290
Feature Type
protein_coding_gene
FlyBase ID
FBgn0034975
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
Histone acetyltransferase (2.3.1.48)
Gene Summary
enoki mushroom (enok) encodes a MYST family histone acetyltransferase that acetylates lysine residues on histones, including H3K23, to regulate gene transcription. It contributes to stem cell self-renewal, oogenesis and neural development. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

rotkehlchen

Key Links
Genomic Location
Cytogenetic map
60B10-60B10
Sequence location
Recombination map
2-106
RefSeq locus
NT_033778 REGION:24099210..24107032
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables histone acetyltransferase activity (H3-K23 specific)
inferred from direct assay
(Huang et al., 2016)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR005818
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables histone acetyltransferase activity
inferred from biological aspect of ancestor with PANTHER:PTN004172615
(assigned by GO_Central )
(Gaudet et al., 2011)
enables histone binding
inferred from biological aspect of ancestor with PANTHER:PTN000064894
(assigned by GO_Central )
(Gaudet et al., 2011)
enables transcription coregulator activity
inferred from biological aspect of ancestor with PANTHER:PTN000064894
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in female germ-line stem cell population maintenance
inferred from mutant phenotype
(Xin et al., 2013)
involved_in histone acetylation
inferred from mutant phenotype
(Feller et al., 2015)
involved_in histone H3 acetylation
inferred from direct assay
(Huang et al., 2016)
involved_in mushroom body development
inferred from mutant phenotype
(Scott et al., 2001)
involved_in negative regulation of stem cell differentiation
inferred from mutant phenotype
(Xin et al., 2013)
inferred from genetic interaction with FLYBASE:bru1; FB:FBgn0000114
(Xin et al., 2013)
involved_in neuroblast proliferation
inferred from mutant phenotype
(Scott et al., 2001)
involved_in regulation of cell cycle
inferred from direct assay
(Huang et al., 2016)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in histone H3 acetylation
inferred from biological aspect of ancestor with PANTHER:PTN000834868
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative regulation of transcription, DNA-templated
inferred from biological aspect of ancestor with PANTHER:PTN000064894
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in nucleosome assembly
inferred from electronic annotation with InterPro:IPR005818
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000064894
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of MOZ/MORF histone acetyltransferase complex
inferred from direct assay
(Huang et al., 2016)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
part_of MOZ/MORF histone acetyltransferase complex
inferred from biological aspect of ancestor with PANTHER:PTN000065047
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of nucleosome
inferred from electronic annotation with InterPro:IPR005818
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine (2.3.1.48)
Predictions / Assertions
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine (2.3.1.48)
Summaries
Gene Snapshot
enoki mushroom (enok) encodes a MYST family histone acetyltransferase that acetylates lysine residues on histones, including H3K23, to regulate gene transcription. It contributes to stem cell self-renewal, oogenesis and neural development. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
ENOK COMPLEX -
The Enok complex (Enok-C) is an histone lysine acetyltransferase 6 (KAT6) complex. The Enok-C preferentially acetylates histone H3 residues. KAT6 complexes are highly conserved in eukaryotes and are involved in cell cycle regulation. (Adapted from FBrf0232456).
HISTONE ACETYLTRANSFERASES -
Histone acetyltransferases catalyze the acetylation of conserved lysine residues on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyl lysine. (Adapted from PMID:11395403).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\enok for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
enok-RA
FBtr0072250
NM_079114
7137
2291
enok-RB
FBtr0343339
NM_001299894
7406
2291
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
enok-PA
FBpp0072159
254.7
2291
8.56
NP_523838
AAF47164
enok-PB
FBpp0309997
254.7
2291
8.56
NP_001286823
AHN56618
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2291 aa isoforms: enok-PA, enok-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\enok using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
wing pouch | restricted
(Molnar et al., 2012)
wing hinge primordium | restricted
(Molnar et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of MOZ/MORF histone acetyltransferase complex
inferred from direct assay
(Huang et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\enok in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of enok
Transgenic constructs containing regulatory region of enok
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(2R)Exel6081
(Ryder, 2004.4.26)
Df(2R)gekD23
(Scott et al., 2001)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile | germline clone
Other Phenotypes
Allele
abnormal developmental rate | larval stage | recessive
abnormal neuroanatomy | somatic clone | third instar larval stage
abnormal size | somatic clone | third instar larval stage
decreased cell number | germline clone | oogenesis | oogenesis | progressive
decreased cell number | larval stage | somatic clone
decreased fecundity | germline clone
flightless, with Scer\GAL4Mef2.PR
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
adult mushroom body | somatic clone
axon | somatic clone | third instar larval stage
egg chamber | germline clone | oogenesis | progressive
embryonic/larval neuron | larval stage
female germline stem cell | germline clone
female germline stem cell | progressive, with Scer\GAL4bab1-Gal4, enokGD4037
female germline stem cell | progressive, with Scer\GAL4bab1-Gal4, enokHM05195
female germline stem cell | progressive, with Scer\GAL4nos.PG
female germline stem cell | progressive | heat sensitive, with Scer\GAL4bab1-Gal4, Scer\GAL80ts.αTub84B
female germline stem cell | progressive | heat sensitive, with Scer\GAL4bab1-Gal4, Scer\GAL80ts.αTub84B, enokGD4037
female germline stem cell | progressive | heat sensitive, with Scer\GAL4bab1-Gal4, Scer\GAL80ts.αTub84B, enokHM05195
germarium cap cell | progressive, with Scer\GAL4bab1-Gal4
germarium cap cell | progressive | heat sensitive, with Scer\GAL4bab1-Gal4, Scer\GAL80ts.αTub84B
germarium cap cell | progressive | somatic clone
mesothoracic tergum, with Scer\GAL4pnr-MD237
myofibril, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KAT6A
9 of 15
Yes
Yes
Hsap\KAT6B
9 of 15
Yes
Yes
Hsap\KAT5
3 of 15
No
No
Hsap\KAT7
3 of 15
No
No
Hsap\KAT8
2 of 15
No
No
Hsap\SAMD1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kat6a
9 of 15
Yes
Yes
Mmus\Kat6b
9 of 15
Yes
Yes
Mmus\Kat5
3 of 15
No
No
Mmus\Kat7
3 of 15
No
No
Mmus\Kat8
1 of 15
No
No
Mmus\Samd1
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Kat6a
5 of 13
Yes
Yes
Rnor\Kat6b
2 of 13
No
Yes
Rnor\Kat7
2 of 13
No
No
Rnor\Kat8
2 of 13
No
No
Rnor\Kat5
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\kat7
3 of 12
Yes
No
Xtro\kat5
2 of 12
No
No
Xtro\kat8
2 of 12
No
No
Xtro\kat6a
1 of 12
No
Yes
Xtro\trim69.1
1 of 12
No
Yes
Xtro\xnf7
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
Drer\kat6a
9 of 15
Yes
Yes
Drer\kat6b
7 of 15
No
Yes
Drer\kat7b
3 of 15
No
No
Drer\kat5a
2 of 15
No
No
Drer\kat5b
2 of 15
No
No
Drer\kat7a
2 of 15
No
No
Drer\kat8
2 of 15
No
No
Drer\samd1b
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\lsy-12
5 of 15
Yes
Yes
Cele\mys-4
4 of 15
No
No
Cele\mys-2
2 of 15
No
No
Cele\mys-1
1 of 15
No
No
Cele\Y22D7AR.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\HAM1
2 of 9
Yes
No
Atha\HAM2
2 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\SAS3
3 of 15
Yes
No
Scer\ESA1
2 of 15
No
No
Scer\SAS2
2 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\mst1
1 of 12
Yes
No
Spom\mst2
1 of 12
Yes
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919006B )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002286
Drosophila simulans
Dsim\GD11835
Drosophila sechellia
Dsec\GM18307
Drosophila erecta
Dere\GG22941
Drosophila yakuba
Dyak\GE14379
Drosophila ananassae
Dana\GF11372
Drosophila pseudoobscura pseudoobscura
Dpse\GA10893
Drosophila persimilis
Dper\GL11667
Drosophila willistoni
Dwil\GK10748
Drosophila virilis
Dvir\GJ21898
Drosophila mojavensis
Dmoj\GI18865
Drosophila grimshawi
Dgri\GH21719
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500J6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015934
Glossina morsitans
Tsetse fly
Gmor\GMOY009235
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08206
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10047
Mayetiola destructor
Hessian fly
Mdes\Mdes008242
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011106
Anopheles darlingi
American malaria mosquito
Adar\ADAC004964
Anopheles gambiae
Malaria mosquito
Agam\AGAP002735
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018518
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018519
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00F5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS213223-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017076
Apis florea
Little honeybee
Aflo\2370960164
Apis mellifera
Western honey bee
Amel\GB41680
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12753
Bombus terrestris
Buff-tailed bumblebee
Bter\15206718
Linepithema humile
Argentine ant
Lhum\LH22861
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000328
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002436
Tribolium castaneum
Red flour beetle
Tcas\TC006477
Pediculus humanus
Human body louse
Phum\PHUM446200
Rhodnius prolixus
Kissing bug
Rpro\RPRC014290
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006752
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000186
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000198
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006572
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04899
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X051G )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004400
Ixodes scapularis
Black-legged tick
Isca\ISCW021150
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83054.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g11600
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_190794
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00D2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Myst2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hypp_194
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000008187
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003191
Gallus gallus
Domestic chicken
Ggal\MYST2
Gallus gallus
Domestic chicken
Ggal\MYST4
Gallus gallus
Domestic chicken
Ggal\KAT6A
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Tip60
5 of 10
CG1894
4 of 10
chm
4 of 10
mof
4 of 10
d4
2 of 10
e(y)3
2 of 10
tth
2 of 10
CG8677
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    enok2
    DOES NOT exacerbate  Huntington's disease
    modeled by Hsap\HTTQ93.ex1.UAS
    (Bodai et al., 2012)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KAT6A; lysine acetyltransferase 6A
    9 of 15
    601408
    KAT6B; lysine acetyltransferase 6B
    9 of 15
    605880
    KAT5; lysine acetyltransferase 5
    3 of 15
    601409
      KAT7; lysine acetyltransferase 7
      3 of 15
      609880
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          Summary of Genetic Interactions
          esyN Network Diagram
          esyN Network Key:
          Suppression
          Enhancement
          View in Interactions Browser
          Please look at the allele data for full details of the genetic interactions
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          enok
          suppressible
          Dl::N
          (Xin et al., 2013)
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          bru1
          enhanceable
          enok
          (Xin et al., 2013)
          elg1
          suppressible
          enok
          (Huang et al., 2016)
          N
          enhanceable
          enok
          (Xin et al., 2013)
          Pc
          suppressible
          enok
          (Umer et al., 2019)
          trx
          enhanceable
          enok
          (Umer et al., 2019)
          External Data
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          External Data
          Linkouts
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          2R
          Recombination map
          2-106
          Cytogenetic map
          60B10-60B10
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          60B10-60B10
          Limits computationally determined from genome sequence between P{EP}EP503 and P{lacW}Nop60Bk05318
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          2-106

          (FlyBase, 2016)

          2-109.9

          (Comeron et al., 2012)
          Left of (cM)
          Right of (cM)
          Notes
          Stocks and Reagents
          Stocks (11)
          Genomic Clones (20)
          cDNA Clones (13)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequenced
          BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           

          polyclonal

          (Huang et al., 2016, Huang et al., 2014)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of

          Source for identity of: enok rot

          (Pankratz, 2001.5.11)
          Source for database merge of

          Source for merge of: enok anon-60Ba

          (Scott et al., 2001)
          Additional comments
          Other Comments

          enok is required for mushroom body neuroblast proliferation.

          (Scott et al., 2001)

          Mutants are defective in food intake and growth.

          (Zinke et al., 2001)

          Transcription unit identified during molecular analysis of the gek region.

          (Luo et al., 1997)
          Origin and Etymology
          Discoverer
          Etymology

          The gene earns its name in reference to the mushroom with a thin stem and small cap.

          (Scott et al., 2001)
          Identification
          External Crossreferences and Linkouts ( 46 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (14)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (76)