FlyBase Gene Report: Dmel\Mmp1

General Information

Symbol

Dmel\Mmp1

Species

D. melanogaster

Name

Matrix metalloproteinase 1

Annotation Symbol

CG4859

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035049

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Snapshot

Matrix metalloproteinase 1 (Mmp1) encodes a proteinase that cleaves proteins in the extracellular matrix. It is involved in tissue histolysis and remodeling during metamorphosis, tracheal remodeling, wound healing, wing regeneration, neoplastic growth, and circadian behavior. It has been used as a reporter for JNK signaling since it is upregulated by the pathway. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

MMP-1, dMMP1, l(2)k04809, matrix metalloprotease 1, Dm1-MMP

Key Links

Genomic Location

Cytogenetic map

60D13-60D14

Sequence location

2R:24,671,294..24,688,184 [-]

Recombination map

2-107

RefSeq locus

NT_033778 REGION:24671294..24688184

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (26 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metalloendopeptidase activity

inferred from biological aspect of ancestor with PANTHER:PTN001303987

(assigned by GO_Central )

(Gaudet et al., 2011)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR016293, InterPro:IPR021190

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (20 terms)

Terms Based on Experimental Evidence (18 terms)

CV Term

Evidence

References

involved_in adult fat body development

inferred from mutant phenotype

(Jia et al., 2014)

involved_in basement membrane disassembly

inferred from mutant phenotype

(Srivastava et al., 2007)

involved_in basement membrane organization

inferred from mutant phenotype

(Stevens and Page-McCaw, 2012)

involved_in cell adhesion

inferred from genetic interaction with FLYBASE:NijA; FB:FBgn0036101

(Zhang et al., 2006)

involved_in cell-cell junction organization

inferred from mutant phenotype

(Jia et al., 2014)

involved_in dorsal trunk growth, open tracheal system

inferred from mutant phenotype

(Page-McCaw et al., 2003)

involved_in embryonic heart tube formation

inferred from mutant phenotype

(Raza et al., 2017)

involved_in extracellular matrix organization

inferred from mutant phenotype

(Glasheen et al., 2010)

involved_in fasciculation of motor neuron axon

inferred from mutant phenotype

(Miller et al., 2008)

involved_in imaginal disc eversion

inferred from mutant phenotype

(Glasheen et al., 2009, Srivastava et al., 2007)

involved_in instar larval development

inferred from mutant phenotype

(Page-McCaw et al., 2003)

involved_in molting cycle, chitin-based cuticle

inferred from mutant phenotype

(Glasheen et al., 2010)

involved_in open tracheal system development

inferred from mutant phenotype

(Uhlirova and Bohmann, 2006)

involved_in regulation of tube length, open tracheal system

inferred from mutant phenotype

(Glasheen et al., 2009)

involved_in response to wounding

inferred from mutant phenotype

(Harris et al., 2020)

involved_in tissue regeneration

inferred from mutant phenotype

(Harris et al., 2020, McClure et al., 2008)

inferred from expression pattern

(McClure et al., 2008)

involved_in ventral cord development

inferred from mutant phenotype

(Meyer et al., 2014)

involved_in wound healing

inferred from mutant phenotype

(Stevens and Page-McCaw, 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in collagen catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001303987

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in extracellular matrix organization

inferred from biological aspect of ancestor with PANTHER:PTN001303987

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR016293, InterPro:IPR021190

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in collagen-containing extracellular matrix

inferred from high throughput direct assay

(Sarov et al., 2016)

located_in dendrite

inferred from mutant phenotype

(Kuo et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in extracellular matrix

inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR021190

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

located_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000810753

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

MATRIX METALLOPROTEASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

MATRIX METALLOPROTEASES -: Matrix metalloproteases (MMPs) belong to MEROPS family M10 and also to the group of peptidases known as the "metzincins", due to a conserved methionine C-terminal to the zinc ligands. They are secreted proteins that function extracellularly. They play important roles in the degradation of extracellular matrix proteins and altering signaling pathways. There are over 20 MMPs in vertebrates, but only 2 in D. melanogaster, which cleave different substrates. (Adapted from FBrf0235071 and FBrf0239469.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mmp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mmp1-RC

FBtr0273263

NM_166683

3105

584

Mmp1-RD

FBtr0273264

NM_079128

2389

541

Mmp1-RE

FBtr0304005

NM_001202070

3880

542

Mmp1-RF

FBtr0304006

NM_001202071

2398

541

Mmp1-RG

FBtr0304007

NM_001202072

2303

541

Mmp1-RH

FBtr0304008

NM_001202073

3024

554

Mmp1-RI

FBtr0304009

NM_001202074

3316

528

Mmp1-RJ

FBtr0304010

NM_001202075

3790

512

Mmp1-RK

FBtr0304011

NM_001202076

3325

528

Mmp1-RL

FBtr0306656

NM_001259570

3781

512

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Mmp1-PC

FBpp0271771

64.7

584

6.63

NP_726473

AAF47255

Mmp1-PD

FBpp0271772

60.3

541

6.71

NP_523852

AAM68327

Mmp1-PE

FBpp0292974

60.6

542

7.99

NP_001188999

ADV37245

Mmp1-PF

FBpp0292975

60.3

541

6.71

NP_001189000

ADV37246

Mmp1-PG

FBpp0292976

60.3

541

6.71

NP_001189001

ADV37247

Mmp1-PH

FBpp0292977

61.5

554

8.38

NP_001189002

ADV37248

Mmp1-PI

FBpp0292978

59.1

528

8.99

NP_001189003

ADV37249

Mmp1-PJ

FBpp0292979

57.4

512

9.39

NP_001189004

ADV37250

Mmp1-PK

FBpp0292980

59.1

528

8.99

NP_001189005

ADV37251

Mmp1-PL

FBpp0297611

57.4

512

9.39

NP_001246499

AFH08252

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

541 aa isoforms: Mmp1-PD, Mmp1-PF, Mmp1-PG

528 aa isoforms: Mmp1-PI, Mmp1-PK

512 aa isoforms: Mmp1-PJ, Mmp1-PL

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mmp1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

prothoracic leg disc

Comment: activated at sites of regeneration

(McClure et al., 2008)

embryonic stage 9 -- 12

midline primordium | subset

(Kearney et al., 2004)

embryonic stage 13

organism | segmentally repeated

(Page-McCaw et al., 2003)

epithelium

(Page-McCaw et al., 2003)

embryonic stage 14

ventral midline of embryo

(Page-McCaw et al., 2003)

embryonic/larval proventriculus

(Page-McCaw et al., 2003)

embryonic/larval posterior spiracle

(Page-McCaw et al., 2003)

embryonic stage 16

embryonic/larval hindgut

(Page-McCaw et al., 2003)

wandering third instar larval stage

air sac primordium

(Page-McCaw et al., 2003)

wing disc | restricted

(Page-McCaw et al., 2003)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

salivary gland

(Lee et al., 2003)

Additional Descriptive Data

Mmp1 expression is activated in prothoracic leg discs after regeneration is induced. It is expressed along the ventral cut site, where the blastema forms, and along the dorsal cut site.

(McClure et al., 2008)

The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.

(Lee et al., 2003)

Mmp1 is expressed in embryos beginning at stage 13. It is expressed in segmentally repeating cells associated with the migrating dorsal epithelium before dorsal closure. It is also expressed at the site of dorsal closure at stage 15. Staining is observed in the ventral midline and in the proventriculus starting at stage 14, in the posterior spiracles at stage 14, and in the hindgut at stage 16. In wandering third instar larvae, expression is observed in the wing disc in a band of cells proximal to the wing hinge, forming a line from the posterior side to the middle of the disc. This band is thought to be the migrating primordia of the adult tracheal airsac. No expression is seen in the leg or eye-antennal discs.

(Page-McCaw et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

prothoracic leg disc

Comment: activated at sites of regeneration

(McClure et al., 2008)

peripodial stalk of wing disc

(Srivastava et al., 2007)

embryonic stage

proventriculus

(Miller et al., 2008)

embryonic/larval hindgut

(Miller et al., 2008)

ventral midline of embryo | segmentally repeated

(Miller et al., 2008)

embryonic/larval peripheral nervous system | restricted

(Miller et al., 2008)

chordotonal organ

(Miller et al., 2008)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Mmp1 expression is activated in prothoracic leg discs after regeneration is induced. It is expressed along the ventral cut site, where the blastema forms, and along the dorsal cut site.

(McClure et al., 2008)

Mmp1 protein expression is prominant in the proventriculus and hindgut. In the embryonic CNS, expression is restricted to small clusters of repeating cells along the midline. Expression is also detected in chordotonal organs in the PNS and in two cells situated in the ventral mesodermal region

(Miller et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in collagen-containing extracellular matrix

inferred from high throughput direct assay

(Sarov et al., 2016)

located_in dendrite

inferred from mutant phenotype

(Kuo et al., 2005)

Expression Deduced from Reporters

Reporter: P{Mmp1.GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

air sac primordium

(Wang et al., 2010)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Mmp1 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mmp1

View exonic expression by tissue for Dmel\Mmp1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035049

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0035049

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4859-RA;CG4859-RB;CG4859-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4859

Flygut - An atlas of the Drosophila adult midgut

FBgn0035049

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Mmp1

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 23 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 19 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mmp1

Transgenic constructs containing regulatory region of Mmp1

Deletions and Duplications ( 4 )

Not disrupted in

Df(2R)bw^VDe2LPx^KR

(Spradling et al., 1999)

Df(2R)Px2

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3R)Pof-D140

(Johansson et al., 2007)

Disrupted in

Df(2R)BSC606

(Christensen et al., 2008.9.3)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | pharate adult stage

Mmp1^Q273stop

lethal | pupal stage

lethal | pupal stage (with Mmp1²)

lethal | pupal stage (with Mmp1^Q112stop)

Mmp1²

lethal | pupal stage (with Mmp1^Q273stop)

Mmp1²

lethal | pupal stage (with Mmp1^W208stop)

Mmp1²

lethal | pupal stage (with Mmp1^W439stop)

Mmp1²

lethal | recessive

Mmp1^k04809

lethal - all die before end of embryonic stage, with Scer\GAL4^Cg.PA

Mmp1^f1.UAS

lethal - all die before end of larval stage

lethal - all die before end of larval stage, with Scer\GAL4^btl.PS

Mmp1^f2.UAS

lethal - all die before end of larval stage, with Scer\GAL4^yolk

Mmp1^F1.C93A.UAS

lethal - all die before end of larval stage (with Mmp1²)

Mmp1^Q112stop

lethal - all die before end of larval stage (with Mmp1^Q112stop)

Mmp1²

lethal - all die before end of pupal stage

lethal - all die before end of pupal stage, with Mmp1^W439stop/Mmp1^Q273stop, Scer\GAL4^αTub84B.PL

lethal - all die before end of pupal stage, with Scer\GAL4^αTub84B.PL

lethal - all die before end of pupal stage (with Mmp1^Q273stop)

Mmp1^W439stop

lethal - all die before end of pupal stage (with Mmp1^Q273stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

lethal - all die before end of pupal stage (with Mmp1^Q273stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

lethal - all die before end of pupal stage (with Mmp1^W439stop)

Mmp1^Q273stop

lethal - all die before end of pupal stage (with Mmp1^W439stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

lethal - all die before end of pupal stage (with Mmp1^W439stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

lethal - all die during embryonic stage, with Scer\GAL4^repo.PL, Scer\GAL4^repo.PU

Mmp1^f2.UAS

lethal - all die during larval stage | heat sensitive, with Scer\GAL4^repo.PL, Scer\GAL4^repo.PU, Scer\GAL80^ts.αTub84B

Mmp1^f2.UAS

partially lethal - majority die | larval stage

partially lethal - majority die | larval stage (with Mmp1²)

partially lethal - majority die | larval stage (with Mmp1^Q112stop)

Mmp1²

partially lethal - majority die | larval stage (with Mmp1^Q273stop)

Mmp1²

partially lethal - majority die | larval stage (with Mmp1^W208stop)

Mmp1²

partially lethal - majority die | larval stage (with Mmp1^W439stop)

Mmp1²

partially lethal - majority die | pupal stage

Mmp1^Q273stop

viable

Mmp1^D140

Sterility

Allele

female semi-fertile, with Scer\GAL4^Act.PU

Mmp1^JF01336

Other Phenotypes

Allele

cell adhesion defective | embryonic stage

Mmp1^Q112stop

cell migration defective | embryonic stage

Mmp1^Q112stop

developmental rate defective, with Scer\GAL4^Lsp2.PH

Mmp1^KK108894

developmental rate defective | larval stage

hypoactive | larval stage, with Mmp1^W439stop/Mmp1^Q273stop

Mmp1^E225A.f1.UAS

hypoactive | larval stage (with Mmp1^Q273stop), with Mmp1^E225A.f1.UAS

Mmp1^W439stop

hypoactive | larval stage (with Mmp1^W439stop), with Mmp1^E225A.f1.UAS

Mmp1^Q273stop

increased occurrence of cell division | larval stage | conditional

Mmp1^Q112stop

neuroanatomy defective | embryonic stage

Mmp1^Q112stop

neuroanatomy defective | embryonic stage, with Scer\GAL4^elav.PU

neuroanatomy defective | embryonic stage, with Scer\GAL4^repo.PU

neuroanatomy defective | embryonic stage (with Mmp1²)

Mmp1^Q112stop

neuroanatomy defective | embryonic stage (with Mmp1^Q112stop)

Mmp1²

neuroanatomy defective | pupal stage

Mmp1^Q273stop

size defective (with Mmp1²)

Mmp1^Q112stop

size defective (with Mmp1^Q112stop)

Mmp1²

size defective | embryonic stage 16, with Scer\GAL4^btl.PS

Mmp1^f2.UAS

size defective | late third instar larval stage

size defective | second instar larval stage

Mmp1²

small body | larval stage (with Mmp1²)

Mmp1^Q112stop

small body | larval stage (with Mmp1^Q112stop)

Mmp1²

some die during embryonic stage, with Scer\GAL4^Cg.PA

Mmp1^f1.UAS

some die during larval stage

some die during larval stage, with Scer\GAL4^btl.PS

Mmp1^f2.UAS

some die during larval stage, with Scer\GAL4^yolk

Mmp1^F1.C93A.UAS

some die during larval stage (with Mmp1²)

Mmp1^Q112stop

some die during larval stage (with Mmp1^Q112stop)

Mmp1²

some die during pupal stage

some die during pupal stage, with Mmp1^W439stop/Mmp1^Q273stop, Scer\GAL4^αTub84B.PL

some die during pupal stage, with Scer\GAL4^αTub84B.PL

some die during pupal stage (with Mmp1^Q273stop)

Mmp1^W439stop

some die during pupal stage (with Mmp1^Q273stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

some die during pupal stage (with Mmp1^Q273stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

some die during pupal stage (with Mmp1^W439stop)

Mmp1^Q273stop

some die during pupal stage (with Mmp1^W439stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

some die during pupal stage (with Mmp1^W439stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

some die during third instar larval stage

Mmp1^Q112stop

wound healing defective | larval stage

Mmp1^Q112stop

Phenotype manifest in

Allele

adult thoracic sensillum, with Scer\GAL4^dpp.PH

Mmp1^f1.UAS

basement membrane | pupal stage

Mmp1^Q273

chaeta, with Scer\GAL4^dpp.PH

Mmp1^f1.UAS

dendritic arborizing neuron | P-stage

Mmp1^Q273stop

egg chamber, with Scer\GAL4^Act.PU

Mmp1^JF01336

egg chamber, with Scer\GAL4^GMR47A04

Mmp1^f1.UAS

embryonic/larval dorsal branch | third instar larval stage

embryonic/larval dorsal branch | third instar larval stage, with Mmp1^W439stop/Mmp1^Q273stop, Scer\GAL4^αTub84B.PL

Mmp1^E225A.f1.UAS

embryonic/larval dorsal branch | third instar larval stage (with Mmp1²)

Mmp1^Q112stop

embryonic/larval dorsal branch | third instar larval stage (with Mmp1^Q112stop)

Mmp1²

embryonic/larval dorsal branch | third instar larval stage (with Mmp1^Q273stop)

Mmp1^W439stop

embryonic/larval dorsal branch | third instar larval stage (with Mmp1^Q273stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

embryonic/larval dorsal branch | third instar larval stage (with Mmp1^W439stop)

Mmp1^Q273stop

embryonic/larval dorsal branch | third instar larval stage (with Mmp1^W439stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

embryonic/larval dorsal trunk

embryonic/larval dorsal trunk, with Scer\GAL4^btl.PS

embryonic/larval dorsal trunk (with Mmp1²)

Mmp1^Q112stop

embryonic/larval dorsal trunk (with Mmp1^Q112stop)

Mmp1²

embryonic/larval fat body, with Scer\GAL4^Cg.PA

Mmp1^F1.C93A.UAS

embryonic/larval fat body, with Scer\GAL4^yolk

Mmp1^F1.C93A.UAS

embryonic/larval posterior spiracle

embryonic/larval trachea (with Mmp1²)

Mmp1^Q112stop

embryonic/larval trachea (with Mmp1^Q112stop)

Mmp1²

embryonic/larval trachea | ectopic

Mmp1^unspecified

embryonic/larval transverse connective (with Mmp1²)

Mmp1^Q112stop

embryonic/larval transverse connective (with Mmp1^Q112stop)

Mmp1²

embryonic heart cardioblast

Mmp1^Q112stop

fat body, with Scer\GAL4^Lsp2.PH

Mmp1^KK108894

filopodium | embryonic stage

Mmp1^Q112stop

follicle cell, with Scer\GAL4^GMR47A04

Mmp1^f1.UAS

head | pupal stage

head | pupal stage, with Mmp1^W439stop/Mmp1^Q273stop, Scer\GAL4^αTub84B.PL

head | pupal stage, with Scer\GAL4^αTub84B.PL

head | pupal stage (with Mmp1^Q273stop)

Mmp1^W439stop

head | pupal stage (with Mmp1^Q273stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

head | pupal stage (with Mmp1^Q273stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

head | pupal stage (with Mmp1^W439stop)

Mmp1^Q273stop

head | pupal stage (with Mmp1^W439stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

head | pupal stage (with Mmp1^W439stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

heart primordium

Mmp1^Q112stop

intersegmental nerve branch ISNb of A1-7

Mmp1^Q112stop

intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^elav.PU

intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^repo.PU

intersegmental nerve branch ISNb of A1-7 (with Mmp1²)

Mmp1^Q112stop

intersegmental nerve branch ISNb of A1-7 (with Mmp1^Q112stop)

Mmp1²

lamellipodium | embryonic stage

Mmp1^Q112stop

larva | third instar larval stage

leg | pupal stage

Mmp1^Q273

macrochaeta & adult thorax, with Scer\GAL4^dpp.PH

Mmp1^f1.UAS

mesothoracic tergum

Mmp1^Q273stop

second instar larval cuticle

Mmp1²

segmental nerve branch SNa of A1-7

Mmp1^Q112stop

segmental nerve branch SNa of A1-7, with Scer\GAL4^elav.PU

Mmp1^f1.UAS

segmental nerve branch SNa of A1-7, with Scer\GAL4^repo.PU

Mmp1^f1.UAS

segmental nerve branch SNa of A1-7 (with Mmp1²)

Mmp1^Q112stop

segmental nerve branch SNa of A1-7 (with Mmp1^Q112stop)

Mmp1²

taenidium | larval stage

taenidium | larval stage (with Mmp1²)

Mmp1^Q112stop

taenidium | larval stage (with Mmp1^Q112stop)

Mmp1²

trachea

Mmp1^Q112stop

wing | pupal stage

wing | pupal stage, with Mmp1^W439stop/Mmp1^Q273stop, Scer\GAL4^αTub84B.PL

wing | pupal stage, with Scer\GAL4^αTub84B.PL

Mmp1^{Pro-pex.f1.UAS}

wing | pupal stage (with Mmp1^Q273stop)

Mmp1^W439stop

wing | pupal stage (with Mmp1^Q273stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

wing | pupal stage (with Mmp1^Q273stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^W439stop

wing | pupal stage (with Mmp1^W439stop)

Mmp1^Q273stop

wing | pupal stage (with Mmp1^W439stop), with Mmp1^E225A.f1.UAS, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

wing | pupal stage (with Mmp1^W439stop), with Mmp1^{Pro-pex.f1.UAS}, Scer\GAL4^αTub84B.PL

Mmp1^Q273stop

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (30)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\MMP14

9 of 15

Yes

Hsap\MMP24

9 of 15

Yes

Hsap\MMP16

8 of 15

Yes

Hsap\MMP15

7 of 15

Yes

Hsap\MMP8

5 of 15

Yes

Hsap\MMP26

5 of 15

Yes

Hsap\MMP1

4 of 15

Yes

Hsap\MMP3

4 of 15

Yes

Hsap\MMP10

4 of 15

Yes

Hsap\MMP12

4 of 15

Yes

Hsap\MMP19

4 of 15

Yes

Hsap\MMP20

4 of 15

Yes

Hsap\MMP25

4 of 15

Yes

Hsap\MMP27

4 of 15

Yes

Hsap\HPX

3 of 15

Yes

Hsap\MMP7

3 of 15

Yes

Hsap\MMP9

3 of 15

Yes

Hsap\MMP11

3 of 15

Yes

Hsap\MMP13

3 of 15

Yes

Hsap\MMP17

3 of 15

Hsap\MMP21

3 of 15

Yes

Hsap\MMP28

3 of 15

Yes

Hsap\ELSPBP1

2 of 15

Yes

Hsap\MMP2

2 of 15

Yes

Hsap\MMP23B

2 of 15

Yes

Hsap\VTN

2 of 15

Yes

Hsap\BSPH1

1 of 15

Yes

Hsap\C17orf50

1 of 15

Yes

Hsap\MMP23A

1 of 15

Yes

Hsap\PRG4

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (28)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Mmp14

9 of 15

Yes

Mmus\Mmp24

9 of 15

Yes

Mmus\Mmp15

8 of 15

Yes

Mmus\Mmp16

8 of 15

Yes

Mmus\Mmp8

5 of 15

Yes

Mmus\Mmp1a

4 of 15

Yes

Mmus\Mmp3

4 of 15

Yes

Mmus\Mmp10

4 of 15

Yes

Mmus\Mmp12

4 of 15

Yes

Mmus\Mmp17

4 of 15

Mmus\Mmp19

4 of 15

Yes

Mmus\Mmp20

4 of 15

Yes

Mmus\Mmp25

4 of 15

Mmus\Mmp27

4 of 15

Yes

Mmus\Mmp28

4 of 15

Yes

Mmus\Mmp1b

3 of 15

Yes

Mmus\Mmp7

3 of 15

Yes

Mmus\Mmp11

3 of 15

Yes

Mmus\Mmp13

3 of 15

Yes

Mmus\Mmp21

3 of 15

Yes

Mmus\Mmp23

3 of 15

Yes

Mmus\Hpx

2 of 15

Yes

Mmus\Mmp2

2 of 15

Yes

Mmus\Mmp9

2 of 15

Yes

Mmus\Vtn

2 of 15

Yes

Mmus\Bsph1

1 of 15

Yes

Mmus\Bsph2

1 of 15

Yes

Mmus\Prg4

1 of 15

Yes

Rattus norvegicus (Norway rat) (28)

Rnor\Mmp14

7 of 13

Yes

Rnor\Mmp15

7 of 13

Yes

Rnor\Mmp16

7 of 13

Yes

Rnor\Mmp24

6 of 13

Yes

Rnor\Mmp8

4 of 13

Yes

Rnor\Mmp10

4 of 13

Yes

Rnor\Mmp12

4 of 13

Yes

Rnor\Mmp19

4 of 13

Yes

Rnor\Mmp20

4 of 13

Yes

Rnor\Mmp27

4 of 13

Yes

Rnor\Mmp1b

3 of 13

Yes

Rnor\Mmp1

3 of 13

Yes

Rnor\Mmp3

3 of 13

Yes

Rnor\Mmp7

3 of 13

Yes

Rnor\Mmp9

3 of 13

Yes

Rnor\Mmp13

3 of 13

Yes

Rnor\Mmp17

3 of 13

Rnor\Mmp21

3 of 13

Yes

Rnor\Mmp23

3 of 13

Yes

Rnor\Mmp28

3 of 13

Yes

Rnor\Hpx

2 of 13

Yes

Rnor\Mmp2

2 of 13

Yes

Rnor\Mmp11

2 of 13

Rnor\LOC100910997

1 of 13

Yes

Rnor\LOC103694864

1 of 13

Yes

Rnor\LOC103694874

1 of 13

Yes

Rnor\Prg4

1 of 13

Yes

Rnor\Vtn

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (34)

Xtro\mmp15

6 of 12

Yes

Xtro\mmp14

5 of 12

Yes

Xtro\mmp16

5 of 12

Yes

Xtro\mmp19

4 of 12

Yes

Xtro\mmp24

4 of 12

Yes

Xtro\mmp28

4 of 12

Yes

Xtro\mmp8

3 of 12

Yes

Xtro\mmp9

3 of 12

Yes

Xtro\mmp11

3 of 12

Yes

Xtro\mmp21

3 of 12

Yes

Xtro\hpx

2 of 12

Yes

Xtro\LOC100127856

2 of 12

Yes

Xtro\LOC100490019

2 of 12

Yes

Xtro\LOC100491547

2 of 12

Yes

Xtro\mmp1

2 of 12

Yes

Xtro\mmp2

2 of 12

Yes

Xtro\mmp3

2 of 12

Yes

Xtro\mmp13

2 of 12

Yes

Xtro\mmp17

2 of 12

Xtro\mmp23b

2 of 12

Yes

Xtro\mmp25

2 of 12

Xtro\prg4

2 of 12

Yes

Xtro\vtn

2 of 12

Yes

Xtro\LOC100489108

1 of 12

Yes

Xtro\LOC100489571

1 of 12

Yes

Xtro\LOC100489735

1 of 12

Yes

Xtro\LOC100489842

1 of 12

Yes

Xtro\LOC100491214

1 of 12

Yes

Xtro\LOC100492075

1 of 12

Yes

Xtro\LOC100493912

1 of 12

Yes

Xtro\LOC101731804

1 of 12

Yes

Xtro\mmp7

1 of 12

Yes

Xtro\mmp9

1 of 12

Yes

Xtro\mmp20

1 of 12

Yes

Danio rerio (Zebrafish) (33)

Drer\mmp14b

9 of 15

Yes

Drer\mmp16b

8 of 15

Yes

Drer\mmp24

8 of 15

Yes

Drer\mmp15a

7 of 15

Yes

Drer\mmp15b

7 of 15

Yes

Drer\mmp14a

6 of 15

Yes

Drer\mmp11b

4 of 15

Yes

Drer\mmp19

4 of 15

Yes

Drer\mmp28

4 of 15

Yes

Drer\mmp9

3 of 15

Yes

Drer\mmp11a

3 of 15

Yes

Drer\mmp13a

3 of 15

Yes

Drer\mmp13b

3 of 15

Yes

Drer\mmp16a

3 of 15

Yes

Drer\mmp17a

3 of 15

Drer\mmp20a

3 of 15

Yes

Drer\mmp20b

3 of 15

Yes

Drer\mmp21

3 of 15

Yes

Drer\mmp23ba

3 of 15

Yes

Drer\mmp23bb

3 of 15

Yes

Drer\mmp25b

3 of 15

Drer\mmp30

3 of 15

Yes

Drer\hpxa

2 of 15

Yes

Drer\hpxb

2 of 15

Yes

Drer\LOC100333071

2 of 15

Yes

Drer\LOC101883213

2 of 15

Yes

Drer\mmp2

2 of 15

Yes

Drer\mmp25a

2 of 15

Yes

Drer\prg4a

2 of 15

Yes

Drer\vtna

2 of 15

Yes

Drer\vtnb

2 of 15

Yes

Drer\mmp17b

1 of 15

Yes

Drer\prg4b

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\zmp-5

12 of 15

Yes

Cele\zmp-6

5 of 15

Yes

Cele\zmp-3

4 of 15

Yes

Cele\zmp-2

3 of 15

Yes

Cele\zmp-4

3 of 15

Yes

Cele\Y50D7A.13

1 of 15

Yes

Cele\zmp-1

1 of 15

Arabidopsis thaliana (thale-cress) (5)

Atha\AT2G45040

4 of 9

Yes

Atha\AT4G16640

4 of 9

Yes

Atha\AT1G24140

3 of 9

Yes

Atha\AT1G59970

3 of 9

Yes

Atha\MMP

3 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919056Q )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\Mmp1

Drosophila persimilis

Dper\GL17167

Drosophila willistoni

Dwil\GK21871

Drosophila virilis

Dvir\GJ21109

Drosophila mojavensis

Dmoj\GI19538

Drosophila grimshawi

Dgri\GH21566

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503JC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17017820

Glossina morsitans

Tsetse fly

Gmor\GMOY010974

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_10010

Mayetiola destructor

Hessian fly

Mdes\Mdes000513

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL005666

Anopheles darlingi

American malaria mosquito

Adar\ADAC001319

Anopheles gambiae

Malaria mosquito

Agam\AGAP006904

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010856

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05BS )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA007804

Danaus plexippus

Monarch butterfly

Dple\DPOGS204463-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006248

Apis florea

Little honeybee

Aflo\3424693380

Apis mellifera

Western honey bee

Amel\GB55889

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24678

Bombus terrestris

Buff-tailed bumblebee

Bter\15213693

Linepithema humile

Argentine ant

Lhum\LH21449

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001945

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG037231

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10356

Tribolium castaneum

Red flour beetle

Tcas\Mmp1

Pediculus humanus

Human body louse

Phum\PHUM302710

Rhodnius prolixus

Kissing bug

Rpro\RPRC013665

Cimex lectularius

Bed bug

Clec\CLEC009827

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005053

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_15856

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05I4 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR002493

Ixodes scapularis

Black-legged tick

Isca\ISCW006136

Stegodyphus mimosarum

African social velvet spider

Smim\KFM67514.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM71952.1

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_303785

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_65034

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03DP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt5/MmpL3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt1-4/MmpL4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp11L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt1-4/MmpL6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp1/3L2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_14

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_12

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt5/MmpL1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp1/3L1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mm24

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-He2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Alg8h

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_15

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Unk_13

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt5/6/MmpL3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt1-4/MmpL5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt5/6L1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt5/6L2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt1-4/MmpL7

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L7

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt5/MmpL2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt1-4/MmpL3

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp18/19L1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mmp13L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt6_mmpL

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Mt4/MmpL

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000022110

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000006263

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000008463

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012822

Ciona intestinalis

Vase tunicate

Cint\LOC100181016

Gallus gallus

Domestic chicken

Ggal\MMP11

Gallus gallus

Domestic chicken

Ggal\MMP28

Gallus gallus

Domestic chicken

Ggal\MMP16

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003580

Gallus gallus

Domestic chicken

Ggal\MMP7

Gallus gallus

Domestic chicken

Ggal\ALG8

Gallus gallus

Domestic chicken

Ggal\MMP17

Gallus gallus

Domestic chicken

Ggal\MMP3

Gallus gallus

Domestic chicken

Ggal\MMP27

Gallus gallus

Domestic chicken

Ggal\MMP1

Gallus gallus

Domestic chicken

Ggal\MMP13

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000001392

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000026297

Gallus gallus

Domestic chicken

Ggal\MMP15

Gallus gallus

Domestic chicken

Ggal\MMP24

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028695

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (4)

Gene Symbol

Score

Source

Alignment

4 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

MMP14; matrix metallopeptidase 14

model of Winchester syndrome

IEA

(FlyBase, 2019-)

MMP20; matrix metallopeptidase 20

model of amelogenesis imperfecta hypomaturation type 2A2

IEA

(FlyBase, 2019-)

MMP1; matrix metallopeptidase 1

model of chronic obstructive pulmonary disease

IEA

(FlyBase, 2019-)

model of recessive dystrophic epidermolysis bullosa

IEA

(FlyBase, 2019-)

MMP13; matrix metallopeptidase 13

model of spondyloepimetaphyseal dysplasia, Missouri type

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

Mmp1^Q112stop

ameliorates fragile X syndrome

modeled by Fmr1^Δ50M

(Siller and Broadie, 2011)

Mmp1^f1.UAS

ameliorates epilepsy

modeled by eas²

(Cho et al., 2018)

Mmp1^KK108894

ameliorates malignant glioma

modeled by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, btl::Egfr^λ.UAS

(Portela et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MMP14; matrix metallopeptidase 14

9 of 15

600754

WINCHESTER SYNDROME; WNCHRS

Winchester syndrome

MMP24; matrix metallopeptidase 24

9 of 15

604871

MMP16; matrix metallopeptidase 16

8 of 15

602262

MMP15; matrix metallopeptidase 15

7 of 15

602261

MMP8; matrix metallopeptidase 8

5 of 15

120355

MMP26; matrix metallopeptidase 26

5 of 15

605470

MMP1; matrix metallopeptidase 1

4 of 15

120353

MMP3; matrix metallopeptidase 3

4 of 15

185250

CORONARY HEART DISEASE, SUSCEPTIBILITY TO, 6; CHDS6

MMP10; matrix metallopeptidase 10

4 of 15

185260

MMP12; matrix metallopeptidase 12

4 of 15

601046

MMP19; matrix metallopeptidase 19

4 of 15

601807

CAVITARY OPTIC DISC ANOMALIES; CODA

MMP20; matrix metallopeptidase 20

4 of 15

604629

AMELOGENESIS IMPERFECTA, HYPOMATURATION TYPE, IIA2; AI2A2

amelogenesis imperfecta hypomaturation type 2A2

MMP25; matrix metallopeptidase 25

4 of 15

608482

MMP27; matrix metallopeptidase 27

4 of 15

618101

HPX; hemopexin

3 of 15

142290

MMP7; matrix metallopeptidase 7

3 of 15

178990

MMP9; matrix metallopeptidase 9

3 of 15

120361

METAPHYSEAL ANADYSPLASIA 2; MANDP2

MMP11; matrix metallopeptidase 11

3 of 15

185261

MMP13; matrix metallopeptidase 13

3 of 15

600108

spondyloepimetaphyseal dysplasia, Missouri type

MMP17; matrix metallopeptidase 17

3 of 15

602285

MMP21; matrix metallopeptidase 21

3 of 15

608416

HETEROTAXY, VISCERAL, 7, AUTOSOMAL; HTX7

MMP28; matrix metallopeptidase 28

3 of 15

608417

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Mmp1

bead aggregation assay, fluorescence microscopy, inferred by author

(LaFever et al., 2017)

Mmp1 - shg

enzymatic study, molecular weight estimation by staining

(Jia et al., 2014)

RNA-RNA

Physical Interaction

Assay

References

Mmp1 - mir-124

quantitative reverse transcription pcr

(Sun et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Mmp1

suppressible

Fmr1

(Siller and Broadie, 2011)

Mmp1

enhanceable

Mmp2

(Miller et al., 2008, Page-McCaw et al., 2003)

Mmp1

suppressible

Sema1a

(Miller et al., 2008)

Mmp1

suppressible

(Glasheen et al., 2010)

Mmp1

suppressible

Timp

(Page-McCaw et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Fmr1

suppressible

Mmp1

(Siller and Broadie, 2011)

Mmp2

enhanceable

Mmp1

(Jia et al., 2014, Miller et al., 2008, Page-McCaw et al., 2003)

Pi3K92E|btl::Egfr

suppressible

Mmp1

(Portela et al., 2019)

Ras85D|scrib

suppressible

Mmp1

(Srivastava et al., 2007, Uhlirova and Bohmann, 2006)

Ras85D|scrib

suppressible

Mmp1|Mmp2

(Uhlirova and Bohmann, 2006)

Sox21a

suppressible

Mmp1

(Zhai et al., 2015)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63521

DroID - A comprehensive database of gene and protein interactions.

FBgn0035049

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37949

MIST (genetic) - An integrated Molecular Interaction Database

Mmp1

MIST (protein-protein) - An integrated Molecular Interaction Database

Mmp1

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-107

Cytogenetic map

60D13-60D14

Sequence location

2R:24,671,294..24,688,184 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60D13-60D14

Limits computationally determined from genome sequence between P{lacW}Nurf-38^k16102 and P{lacW}Mmp1^k04809

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60D13-60D14

(Llano, 2000.5.24, BDGP Project Members, 1994-1999)

60D13-60D14

(determined by in situ hybridisation)

(Spradling et al., 1999)

Experimentally Determined Recombination Data

Location

2-107

(FlyBase, 2016)

2-111.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

58700

58701

58702

58709

31489

y¹ v¹; P{TRiP.JF01336}attP2

58703

w^*; P{UAS-Mmp1.f2}3/TM3, Sb¹

35918

y¹ w^*; Mi{MIC}Mmp1^MI03010

37224

y¹ w^*; Mi{MIC}Mmp1^MI03787

Kyoto

125344

w¹¹¹⁸; P{RS5}Mmp1^5-HA-1685

VDRC

v330331

P{VSH330331}attP40

v101505

P{KK108894}VIE-260B

v318052

PBac{fTRG00145.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (62)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035049

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035049

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37949

Antibody Information

Laboratory Generated Antibodies

monoclonal

(LaFever et al., 2017, Page-McCaw et al., 2003)

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: MMP CG4859

(FlyBase, 1996-)

Source for database merge of

Source for merge of: Mmp1 l(2)k04809

(Page-McCaw et al., 2003)

Additional comments

Source for identity of MMP CG4859 was sequence comparison ( date:001123 ).

(FlyBase, 1996-)

Other Comments

Mmp1 delimits imaginal disc regeneration by regulating the cell-cycle arrest of non-blastema cells.

(McClure et al., 2008)

The last 40 amino acid residues of Mmp1 are necessary for a strong interaction with NijA.

(Zhang et al., 2006)

NijA and Mmp1 proteins can form a stable complex.

(Zhang et al., 2006)

Mmp1 expression is required for NijA-induced loss of adhesion.

(Zhang et al., 2006)

Mutants are larval lethal with defects in the tracheal system.

(Page-McCaw et al., 2002)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 88 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37949

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035049

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035049

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4859

Flygut - An atlas of the Drosophila adult midgut

FBgn0035049

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

37949

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014266

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4859

modMine - A data warehouse for the modENCODE project

FBgn0035049

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

BioGRID - A database of protein and genetic interactions.

63521

DroID - A comprehensive database of gene and protein interactions.

FBgn0035049

DRSC - Results frm RNAi screens

FBgn0035049

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0035049

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG4859-RA;CG4859-RB;CG4859-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035049

FlyMine - An integrated database for Drosophila genomics

FBgn0035049

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

37949

MIST (genetic) - An integrated Molecular Interaction Database

Mmp1

MIST (protein-protein) - An integrated Molecular Interaction Database

Mmp1

Synonyms and Secondary IDs (29)

Reported As

Symbol Synonym

CG4859

(Widmer et al., 2018, Meadows, 2017.1.11, Mosallanejad et al., 2010, Keleman et al., 2009.8.5, Carrera et al., 2008, Ni et al., 2008, Valanne et al., 2007, Johansson et al., 2005, Klebes et al., 2005, Gorski et al., 2003, Lee et al., 2003, Boutros et al., 2002, Coates et al., 2000, Llano, 2000.5.24)

Dm1-MMP

(McFarlane, 2003, Llano et al., 2002, Llano, 2000.5.24)

MMP

(Bai and Suzuki, 2020, Fei et al., 2017)

MMP-1

(Mirzoyan et al., 2019, Xu et al., 2018, Dewey and Johnston, 2017, Purice et al., 2017, Siller and Broadie, 2012, Classen et al., 2009)

MMP1

(Hughes et al., 2020, Portela et al., 2020, Li et al., 2019, Ma et al., 2019, Cong et al., 2018, Dutta et al., 2018, Thuma et al., 2018, Wang et al., 2018, Hughes and Jacobs, 2017, Ismail et al., 2017, Ma et al., 2017, Ma et al., 2017, Romani et al., 2017, Willoughby et al., 2017, Harris et al., 2016, Jaszczak and Halme, 2016, Levinson and Cagan, 2016, Ma et al., 2016, Ordan and Volk, 2016, Zheng et al., 2016, Grifoni et al., 2015, Shaukat et al., 2015, Srivastava, 2015, Hauling et al., 2014, Ma et al., 2014, Shen et al., 2014, Bangi, 2013, Das et al., 2013, Dekanty and Milán, 2013, Khan et al., 2013, Ma et al., 2013, Nakajima et al., 2013, Petzoldt et al., 2013, Bangi et al., 2012, Chountala et al., 2012, Jiang et al., 2011, Meyer et al., 2011, Miles et al., 2011, Siller and Broadie, 2011, Warner et al., 2010, Rodahl et al., 2009, Bakal et al., 2008, Curtin et al., 2007, Gesellchen et al., 2005)

MMp1

(Pallavi et al., 2012)

Mmp 1

(Johansson et al., 2005)

Mmp-1

(Martín and Morata, 2018, Repiso et al., 2011)

Mmp1

(Choubey et al., 2020, Diaz-de-la-Loza et al., 2020, Geigges et al., 2020, La Marca and Richardson, 2020, Parniewska and Stocker, 2020, Sun et al., 2020, Zhou and Boutros, 2020, Bouska et al., 2019, Kanda et al., 2019, Kurelac et al., 2019, Parvy et al., 2019, Ramos-Lewis and Page-McCaw, 2019, Sanchez et al., 2019, Sauerwald et al., 2019, Singh et al., 2019, Sun et al., 2019, Yang et al., 2019, Cho et al., 2018, Eichenlaub et al., 2018, Luong et al., 2018, Pinal et al., 2018, Richardson and Portela, 2018, Tsai et al., 2018, Widmer et al., 2018, Wu et al., 2018, Aggarwal et al., 2017, Cannon et al., 2017, Jia et al., 2017, Kline et al., 2017, LaFever et al., 2017, Martín et al., 2017, O'Farrell et al., 2017, Ray et al., 2017, Song et al., 2017, Taylor et al., 2017, Wang et al., 2017, Gene Disruption Project members, 2016-, Harris et al., 2016, Öztürk-Çolak et al., 2016, Pearson et al., 2016, Sarov et al., 2016, Small and Crawford, 2016, Andersen et al., 2015, Aradska et al., 2015, Casas-Tintó et al., 2015, Deady et al., 2015, Doggett et al., 2015, Feng and Martin, 2015, Katsuyama et al., 2015, Liu et al., 2015, Schleede and Blair, 2015, Zang et al., 2015, Zhai et al., 2015, Depetris-Chauvin et al., 2014, Fernández et al., 2014, Jia et al., 2014, Skwarek et al., 2014, Thomas and Strutt, 2014, Wang and Page-McCaw, 2014, Das et al., 2013, Das et al., 2013, Khoo et al., 2013, Rudrapatna et al., 2013, Sotillos et al., 2013, Woodfield et al., 2013, Zhu and Zhang, 2013, Gurudatta et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lee et al., 2012, Stevens and Page-McCaw, 2012, Sun et al., 2012, Worley et al., 2012, Huang et al., 2011, Miller et al., 2011, Schmidt et al., 2011, Waldholm et al., 2011, Glasheen et al., 2010, Neisch et al., 2010, Padash-Barmchi et al., 2010, Vaccari et al., 2010, Windler and Bilder, 2010, Yasunaga et al., 2010, Glasheen et al., 2009, Graham et al., 2009, Guha et al., 2009, Kadener et al., 2009, Roeder et al., 2009, Carrera et al., 2008, Christensen et al., 2008.9.3, McClure et al., 2008, Miller et al., 2008, Morrison et al., 2008, Sustar et al., 2008, Beaucher et al., 2007, Glasheen et al., 2007, Johansson et al., 2007, Kadener et al., 2007, Menut et al., 2007, Page-McCaw et al., 2007, Srivastava et al., 2007, Zeitouni et al., 2007, Meyer and Aberle, 2006, Uhlirova and Bohmann, 2006, Zhang et al., 2006, Page-McCaw et al., 2003)

dMMP1

(Yang et al., 2017, Hirabayashi et al., 2013, Cordero et al., 2010, Read et al., 2009)

dm1-MMP

(Wei et al., 2003)

dmmp1

(Singh et al., 2010, Vidal et al., 2010)

l(2)k04809

(Page-McCaw et al., 2003, Spradling et al., 1999)

mmp-1

(Galenza and Foley, 2019)

Name Synonyms

Extracellular matrix metalloproteinase

(Bai and Suzuki, 2020)

Matrix metalloproteinase 1

(Paul et al., 2018)

Matrix Metalloproteinase 1

(Sustar et al., 2008)

Matrix Metalloprotinase 1

(Rudrapatna et al., 2014)

Matrix metalloprotease 1

(Woodfield et al., 2013, Vaccari et al., 2010)

Matrix metalloproteinase 1

(Ordan and Volk, 2016, Neisch et al., 2010, Padash-Barmchi et al., 2010, Gesellchen et al., 2005, Llano, 2000.5.24)

Matrix metalloproteinase-1

(Repiso et al., 2011, McClure et al., 2008)

Matrix metalloproteinase1

(Calleja et al., 2016, Felix et al., 2012)

matrix metalloprotease

(Das et al., 2013)

matrix metalloprotease 1

(Sun et al., 2020, Rodahl et al., 2009, Morrison et al., 2008)

matrix metalloproteinase 1

(Yadav et al., 2017, Zhai et al., 2015, Wang et al., 2010)

matrix metalloproteinase-1

(Khan et al., 2013)

metalloprotease 1

(Pinal et al., 2018)

metalloproteinase

(Weavers and Skaer, 2013)

Secondary FlyBase IDs

FBgn0022198

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (259)

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