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Gene Dmel\Mmp1

General Information
Symbol	Dmel\Mmp1	Species	D. melanogaster
Name	Matrix metalloproteinase 1	Annotation symbol	CG4859
Feature type	protein_coding_gene	FlyBase ID	FBgn0035049
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	dm1-MMP, dmmp1, l(2)k04809
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60D13-60D14	Sequence location	2R:20,558,817..20,575,704 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Matrix metalloproteinase 1 is referred to in FlyBase by the symbol Dmel\Mmp1 (CG4859, FBgn0035049). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: metalloendopeptidase activity. There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; cellular process; open tracheal system development; growth; programmed cell death; single-organism developmental process; extracellular structure organization; developmental growth; wound healing; molting cycle, chitin-based cuticle; gland morphogenesis; biological regulation; post-embryonic organ morphogenesis; cellular component organization; instar larval development. 36 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/larval trachea; embryonic/larval posterior spiracle; second instar larval cuticle; chaeta; embryonic/larval dorsal trunk; adult thoracic sensillum; mesothoracic tergum; embryonic/larval fat body; third instar larva; embryonic/larval transverse connective. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Hemopexin, conserved site; Hemopexin-like domain; Hemopexin-like repeats; Metallopeptidase, catalytic domain; Peptidase M10, metallopeptidase; Peptidase M10A; Peptidase M10A, metazoans; Peptidase, metallopeptidase; Peptidoglycan binding-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult midgut, larval/adult hindgut, adult Malpighian tubules, larval fat body, larval trachea, larval carcass. Gene sequence location is 2R:20558817..20575704.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60D13-60D14   Limits computationally determined from genome sequence between P{lacW}Nurf-38k16102 and P{lacW}Mmp1k04809
Experimentally Determined Cytological Location
Cytogenetic map Notes References 60D13-60D14     (Llano, 2000.5.24) 60D13-60D13   (determined by in situ hybridisation)   (Llano et al., 2000) 60D13-60D14   (determined by in situ hybridisation)   (Spradling et al., 1999) 60D13-60D14     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mmp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mmp1-RC FBtr0273263  NM_166683   3102   584 Mmp1-RD FBtr0273264  NM_079128   2386   541 Mmp1-RE FBtr0304005  NM_001202070   3880   542 Mmp1-RF FBtr0304006  NM_001202071   2398   541 Mmp1-RG FBtr0304007  NM_001202072   2300   541 Mmp1-RH FBtr0304008  NM_001202073   3024   554 Mmp1-RI FBtr0304009  NM_001202074   3313   528 Mmp1-RJ FBtr0304010  NM_001202075   3790   512 Mmp1-RK FBtr0304011  NM_001202076   3325   528 Mmp1-RL FBtr0306656  NM_001259570   3758   512
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mmp1-PC   FBpp0271771   64.7   584   6.63     NP_726473   AAF47255 Mmp1-PD   FBpp0271772   60.3   541   6.71     NP_523852   AAM68327 Mmp1-PE   FBpp0292974   60.6   542   7.99     NP_001188999   ADV37245 Mmp1-PF   FBpp0292975   60.3   541   6.71     NP_001189000   ADV37246 Mmp1-PG   FBpp0292976   60.3   541   6.71     NP_001189001   ADV37247 Mmp1-PH   FBpp0292977   61.5   554   8.38     NP_001189002   ADV37248 Mmp1-PI   FBpp0292978   59.1   528   8.99     NP_001189003   ADV37249 Mmp1-PJ   FBpp0292979   57.4   512   9.39     NP_001189004   ADV37250 Mmp1-PK   FBpp0292980   59.1   528   8.99     NP_001189005   ADV37251 Mmp1-PL   FBpp0297611   57.4   512   9.39     NP_001246499   AFH08252
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Hemopexin, conserved site (IPR018486) Hemopexin-like repeats (IPR018487) Hemopexin-like domain (IPR000585) Peptidase M10, metallopeptidase (IPR001818) Peptidoglycan binding-like (IPR002477) Peptidase, metallopeptidase (IPR006026) Peptidase M10A, metazoans (IPR016293) Metallopeptidase, catalytic domain (IPR024079) Peptidase M10A (IPR021190)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF47255   AE013599 AAM68327   AE013599 ADV37245   AE013599 ADV37246   AE013599 ADV37247   AE013599 ADV37248   AE013599 ADV37249   AE013599 ADV37250   AE013599 ADV37251   AF271666 AAG33131   AE013599 AFH08252   AI259232   AQ025748   AY118405 AAM48434   BI374588   BI583471   BI584673   BI584688   BP556656   BT021303 AAX33451   BT044557   BT120164   CA803271   CA803510   CO153456   CO154768   CO155371   CO178418   CO183816   CO273732   CO273733   CO279814   CO286593   CO292977   CO295815   CO308579   CO332215   CO335741   CO335947   CO336073   CO338640   CO341303   CO344854   CZ473420   CZ477342   CZ479020   CZ490646   EC058058   EC058324   EC083434   EC198090   EC203767   EC212892   EC228040   EC247088   EC253889   EC254720   EC260718   EC261091   EC261687   EC262263   EC262855   EC263657   EC265031   ES690982   ES695655   ES696069   ES696070   ES696072   ES696075   ES696078   ES696081   ES696084   ES696085   ES696087   ES696089   ES696090   ES696091   ES696096   ES696097   ES696098   ES696099   ES696101   ES696104   EV585508   GH946529   GH947315   GH948488   GH950773   GH952716   GH952792   GH957569   GH961090   GH966837   GH970234   GH973397   GH974935   GH978801   GH978820   GH979344   GH983716
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MLN6 Q9W122 Q9GTK3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic proventriculus   (Fisher et al., 2012) embryonic salivary gland duct   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) embryonic/larval salivary gland common duct   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) midline ventral glial cell   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) third instar larval stage   prothoracic leg disc   (McClure et al., 2008) Comment:activated at sites of regeneration northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage   salivary gland   (Lee et al., 2003)
Additional Descriptive Data
	The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue. (Lee et al., 2003) Mmp1 expression is activated in prothoracic leg discs after regeneration is induced. It is expressed along the ventral cut site, where the blastema forms, and along the dorsal cut site. (McClure et al., 2008)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   prothoracic leg disc   (McClure et al., 2008) Comment:activated at sites of regeneration
Additional Descriptive Data
	Mmp1 expression is activated in prothoracic leg discs after regeneration is induced. It is expressed along the ventral cut site, where the blastema forms, and along the dorsal cut site. (McClure et al., 2008)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
dendrite inferred from mutant phenotype (Kuo et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval midgut, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult midgut, larval/adult hindgut, adult Malpighian tubules, larval fat body, larval trachea, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    39 central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    162 digestive system, larvae L3 wandering    75 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    40 fat body, larvae L3 wandering    22 fat body, white prepupae    67 fat body, pupae P8    51 carcass, larvae L3 wandering    96 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (39) central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (162) digestive system, larvae L3 wandering  (75) digestive system, 1-day adult  (28) digestive system, 4-day adult  (38) digestive system, 20-day adult  (40) fat body, larvae L3 wandering    22 fat body, white prepupae  (67) fat body, pupae P8  (51) carcass, larvae L3 wandering  (96) carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    39 central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (162) digestive system, larvae L3 wandering    75 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    40 fat body, larvae L3 wandering    22 fat body, white prepupae    67 fat body, pupae P8    51 carcass, larvae L3 wandering    96 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    39 central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    162 digestive system, larvae L3 wandering    75 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    40 fat body, larvae L3 wandering    22 fat body, white prepupae    67 fat body, pupae P8    51 carcass, larvae L3 wandering    96 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    39 central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    162 digestive system, larvae L3 wandering    75 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    40 fat body, larvae L3 wandering    22 fat body, white prepupae    67 fat body, pupae P8    51 carcass, larvae L3 wandering    96 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3  (39) central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (162) digestive system, larvae L3 wandering  (75) digestive system, 1-day adult  28 digestive system, 4-day adult  (38) digestive system, 20-day adult  (40) fat body, larvae L3 wandering    22 fat body, white prepupae  (67) fat body, pupae P8  (51) carcass, larvae L3 wandering  (96) carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    39 central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae  (162) digestive system, larvae L3 wandering    75 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    40 fat body, larvae L3 wandering    22 fat body, white prepupae    67 fat body, pupae P8    51 carcass, larvae L3 wandering    96 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    39 central nervous system, pupae P8    10 head, virgin 1-day female    16 head, virgin 4-day female    10 head, virgin 20-day female    8 head, mated 1-day female    14 head, mated 4-day female    11 head, mated 20-day female    7 head, mated 1-day male    16 head, mated 4-day male    20 head, mated 20-day male    17 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    162 digestive system, larvae L3 wandering    75 digestive system, 1-day adult    28 digestive system, 4-day adult    38 digestive system, 20-day adult    40 fat body, larvae L3 wandering    22 fat body, white prepupae    67 fat body, pupae P8    51 carcass, larvae L3 wandering    96 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    21 ovary, virgin 4-day female    0 ovary, mated 4-day female    1 testis, mated 4-day male    4 accessory gland, mated 4-day male    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr    36 embryo 20-22hr    24 embryo 22-24hr    29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    90 white prepupae new    161 white prepupae 12hr    284 white prepupae 24hr    69 pupae 2d postWPP    32 pupae 3d postWPP    8 pupae 4d postWPP    393 adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr  (36) embryo 20-22hr    24 embryo 22-24hr  (29) larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (90) white prepupae new  (161) white prepupae 12hr  (284) white prepupae 24hr  (69) pupae 2d postWPP  (32) pupae 3d postWPP    8 pupae 4d postWPP  (393) adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr    36 embryo 20-22hr    24 embryo 22-24hr    29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    90 white prepupae new  (161) white prepupae 12hr  (284) white prepupae 24hr    69 pupae 2d postWPP    32 pupae 3d postWPP    8 pupae 4d postWPP  (393) adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr    36 embryo 20-22hr    24 embryo 22-24hr    29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    90 white prepupae new    161 white prepupae 12hr    284 white prepupae 24hr    69 pupae 2d postWPP    32 pupae 3d postWPP    8 pupae 4d postWPP    393 adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr    36 embryo 20-22hr    24 embryo 22-24hr    29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    90 white prepupae new    161 white prepupae 12hr    284 white prepupae 24hr    69 pupae 2d postWPP    32 pupae 3d postWPP    8 pupae 4d postWPP    393 adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr  (36) embryo 20-22hr    24 embryo 22-24hr  29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (90) white prepupae new  (161) white prepupae 12hr  (284) white prepupae 24hr  (69) pupae 2d postWPP  32 pupae 3d postWPP    8 pupae 4d postWPP  (393) adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr    36 embryo 20-22hr    24 embryo 22-24hr    29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    90 white prepupae new  (161) white prepupae 12hr  (284) white prepupae 24hr    69 pupae 2d postWPP    32 pupae 3d postWPP    8 pupae 4d postWPP  (393) adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    1 embryo 10-12hr    2 embryo 12-14hr    4 embryo 14-16hr    8 embryo 16-18hr    18 embryo 18-20hr    36 embryo 20-22hr    24 embryo 22-24hr    29 larva L1    10 larva L2    8 larva L3 12hr old    13 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    90 white prepupae new    161 white prepupae 12hr    284 white prepupae 24hr    69 pupae 2d postWPP    32 pupae 3d postWPP    8 pupae 4d postWPP    393 adult male 01day    23 adult male 05day    15 adult male 30day    19 adult female 01day    16 adult female 05day    4 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    89 embryonic Kc167    30 embryonic S1    14 embryonic S3    1 leg disc CME L1    26 wing disc CME-W2    58 wing disc ML-DmD8    99 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    6 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    39 ovary fGS/OSS    15 ovary OSC    66 ovary OSS    152 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2  (89) embryonic Kc167  (30) embryonic S1    14 embryonic S3    1 leg disc CME L1  26 wing disc CME-W2  (58) wing disc ML-DmD8  (99) wing disc ML-DmD9  (32) wing disc ML-DmD16-c3  (32) wing disc ML-DmD21    6 wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (39) ovary fGS/OSS    15 ovary OSC  (66) ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    89 embryonic Kc167    30 embryonic S1    14 embryonic S3    1 leg disc CME L1    26 wing disc CME-W2    58 wing disc ML-DmD8    99 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    6 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    39 ovary fGS/OSS    15 ovary OSC    66 ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    89 embryonic Kc167    30 embryonic S1    14 embryonic S3    1 leg disc CME L1    26 wing disc CME-W2    58 wing disc ML-DmD8    99 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    6 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    39 ovary fGS/OSS    15 ovary OSC    66 ovary OSS    152 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    89 embryonic Kc167    30 embryonic S1    14 embryonic S3    1 leg disc CME L1    26 wing disc CME-W2    58 wing disc ML-DmD8    99 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    6 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    39 ovary fGS/OSS    15 ovary OSC    66 ovary OSS    152 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2  (89) embryonic Kc167  30 embryonic S1    14 embryonic S3    1 leg disc CME L1  26 wing disc CME-W2  (58) wing disc ML-DmD8  (99) wing disc ML-DmD9  32 wing disc ML-DmD16-c3  32 wing disc ML-DmD21    6 wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (39) ovary fGS/OSS    15 ovary OSC  (66) ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    89 embryonic Kc167    30 embryonic S1    14 embryonic S3    1 leg disc CME L1    26 wing disc CME-W2    58 wing disc ML-DmD8    99 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    6 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    39 ovary fGS/OSS    15 ovary OSC    66 ovary OSS  (152) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    3 Schneider line 2 Sg4    18 embryonic 1182-4H    13 embryonic GM2    89 embryonic Kc167    30 embryonic S1    14 embryonic S3    1 leg disc CME L1    26 wing disc CME-W2    58 wing disc ML-DmD8    99 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    6 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    14 eye-antennal disc ML-DmD11    13 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    19 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    39 ovary fGS/OSS    15 ovary OSC    66 ovary OSS    152 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (28) cold shock, 4-day adult  (28) heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3  (30) Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  28 cold shock, 4-day adult  28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3  30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (42) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    28 cold shock, 4-day adult    28 heat shock, 4-day adult    8 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    30 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    42 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    11 Ethanol 5% 3 hrs, larvae L3    11 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    7 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    14 Paraquat 10 mM 48 hrs, 4-day adult    13 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • RE62222 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035049 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4859-RA;CG4859-RB;CG4859-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Mmp1 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage, with Scer\GAL4Cg.PA Mmp1f1.Scer\UAS lethal | larval stage Mmp12 Mmp1Q112stop lethal | larval stage, with Scer\GAL4btl.PS Mmp1f2.Scer\UAS lethal | larval stage, with Scer\GAL4yolk Mmp1F1.C93A.Scer\UAS lethal | larval stage (with Mmp12) Mmp1Q112stop lethal | larval stage (with Mmp1Q112stop) Mmp12 lethal | pharate adult stage Mmp1Q273stop lethal | pupal stage Mmp1Q273stop Mmp1W208stop Mmp1W439stop lethal | pupal stage, with Mmp1W439stop/Mmp1Q273stop, Scer\GAL4αTub84B.PL Mmp1E225A.f1.Scer\UAS Mmp1Pro-pex.f1.Scer\UAS lethal | pupal stage, with Scer\GAL4αTub84B.PL Mmp1E225A.f1.Scer\UAS Mmp1E225A.f2.Scer\UAS Mmp1Pro-pex.f1.Scer\UAS lethal | pupal stage (with Mmp12) Mmp1Q112stop Mmp1Q273stop Mmp1W208stop Mmp1W439stop lethal | pupal stage (with Mmp1Q112stop) Mmp12 lethal | pupal stage (with Mmp1Q273stop) Mmp12 Mmp1W439stop lethal | pupal stage (with Mmp1Q273stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop lethal | pupal stage (with Mmp1Q273stop), with Mmp1Pro-pex.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop lethal | pupal stage (with Mmp1W208stop) Mmp12 lethal | pupal stage (with Mmp1W439stop) Mmp12 Mmp1Q273stop lethal | pupal stage (with Mmp1W439stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop lethal | pupal stage (with Mmp1W439stop), with Mmp1Pro-pex.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop lethal | recessive Mmp1k04809 partially lethal - majority die | larval stage Mmp1Q273stop Mmp1W208stop Mmp1W439stop partially lethal - majority die | larval stage (with Mmp12) Mmp1Q112stop Mmp1Q273stop Mmp1W208stop Mmp1W439stop partially lethal - majority die | larval stage (with Mmp1Q112stop) Mmp12 partially lethal - majority die | larval stage (with Mmp1Q273stop) Mmp12 partially lethal - majority die | larval stage (with Mmp1W208stop) Mmp12 partially lethal - majority die | larval stage (with Mmp1W439stop) Mmp12 partially lethal - majority die | pupal stage Mmp1Q273stop viable Mmp1D140 Other Phenotypes Allele developmental rate defective | larval stage Mmp1Q112stop Mmp1W208stop hypoactive | larval stage, with Mmp1W439stop/Mmp1Q273stop Mmp1E225A.f1.Scer\UAS hypoactive | larval stage (with Mmp1Q273stop), with Mmp1E225A.f1.Scer\UAS Mmp1W439stop hypoactive | larval stage (with Mmp1W439stop), with Mmp1E225A.f1.Scer\UAS Mmp1Q273stop neuroanatomy defective | pupal stage Mmp1Q273stop size defective (with Mmp12) Mmp1Q112stop size defective (with Mmp1Q112stop) Mmp12 size defective | embryonic stage 16, with Scer\GAL4btl.PS Mmp1f2.Scer\UAS size defective | late third instar larval stage Mmp12 Mmp1Q273stop size defective | second instar larval stage Mmp12 small body | larval stage (with Mmp12) Mmp1Q112stop small body | larval stage (with Mmp1Q112stop) Mmp12 Phenotype manifest in Allele adult thoracic sensillum, with Scer\GAL4dpp.PH Mmp1f1.Scer\UAS basement membrane | pupal stage Mmp1Q273 chaeta, with Scer\GAL4dpp.PH Mmp1f1.Scer\UAS dendritic arborizing neuron | P-stage Mmp1Q273stop embryonic/larval dorsal branch | third instar larval stage Mmp12 Mmp1Q112stop Mmp1Q273stop Mmp1W439stop embryonic/larval dorsal branch | third instar larval stage, with Mmp1W439stop/Mmp1Q273stop, Scer\GAL4αTub84B.PL Mmp1E225A.f1.Scer\UAS embryonic/larval dorsal branch | third instar larval stage (with Mmp12) Mmp1Q112stop embryonic/larval dorsal branch | third instar larval stage (with Mmp1Q112stop) Mmp12 embryonic/larval dorsal branch | third instar larval stage (with Mmp1Q273stop) Mmp1W439stop embryonic/larval dorsal branch | third instar larval stage (with Mmp1Q273stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop embryonic/larval dorsal branch | third instar larval stage (with Mmp1W439stop) Mmp1Q273stop embryonic/larval dorsal branch | third instar larval stage (with Mmp1W439stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop embryonic/larval dorsal trunk Mmp12 Mmp1k04809 Mmp1unspecified embryonic/larval dorsal trunk, with Scer\GAL4btl.PS Mmp1f2.Scer\UAS Mmp1dsRNA.Scer\UAS embryonic/larval dorsal trunk (with Mmp12) Mmp1Q112stop embryonic/larval dorsal trunk (with Mmp1Q112stop) Mmp12 embryonic/larval fat body, with Scer\GAL4Cg.PA Mmp1F1.C93A.Scer\UAS embryonic/larval fat body, with Scer\GAL4yolk Mmp1F1.C93A.Scer\UAS embryonic/larval posterior spiracle Mmp12 Mmp1k04809 Mmp1unspecified embryonic/larval trachea (with Mmp12) Mmp1Q112stop embryonic/larval trachea (with Mmp1Q112stop) Mmp12 embryonic/larval trachea | ectopic Mmp1unspecified embryonic/larval transverse connective (with Mmp12) Mmp1Q112stop embryonic/larval transverse connective (with Mmp1Q112stop) Mmp12 head | pupal stage Mmp1Q273stop Mmp1W439stop head | pupal stage, with Mmp1W439stop/Mmp1Q273stop, Scer\GAL4αTub84B.PL Mmp1E225A.f1.Scer\UAS Mmp1Pro-pex.f1.Scer\UAS head | pupal stage, with Scer\GAL4αTub84B.PL Mmp1E225A.f1.Scer\UAS Mmp1E225A.f2.Scer\UAS Mmp1Pro-pex.f1.Scer\UAS head | pupal stage (with Mmp1Q273stop) Mmp1W439stop head | pupal stage (with Mmp1Q273stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop head | pupal stage (with Mmp1Q273stop), with Mmp1Pro-pex.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop head | pupal stage (with Mmp1W439stop) Mmp1Q273stop head | pupal stage (with Mmp1W439stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop head | pupal stage (with Mmp1W439stop), with Mmp1Pro-pex.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop leg | pupal stage Mmp1Q273 macrochaeta & adult thorax, with Scer\GAL4dpp.PH Mmp1f1.Scer\UAS mesothoracic tergum Mmp1Q273stop second instar larval cuticle Mmp12 taenidium | larval stage Mmp12 Mmp1Q273stop taenidium | larval stage (with Mmp12) Mmp1Q112stop taenidium | larval stage (with Mmp1Q112stop) Mmp12 third instar larva Mmp1Q112stop Mmp1W208stop wing | pupal stage Mmp1W439stop Mmp1Q273 wing | pupal stage, with Mmp1W439stop/Mmp1Q273stop, Scer\GAL4αTub84B.PL Mmp1E225A.f1.Scer\UAS Mmp1Pro-pex.f1.Scer\UAS wing | pupal stage, with Scer\GAL4αTub84B.PL Mmp1Pro-pex.f1.Scer\UAS wing | pupal stage (with Mmp1Q273stop) Mmp1W439stop wing | pupal stage (with Mmp1Q273stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop wing | pupal stage (with Mmp1Q273stop), with Mmp1Pro-pex.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1W439stop wing | pupal stage (with Mmp1W439stop) Mmp1Q273stop wing | pupal stage (with Mmp1W439stop), with Mmp1E225A.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop wing | pupal stage (with Mmp1W439stop), with Mmp1Pro-pex.f1.Scer\UAS, Scer\GAL4αTub84B.PL Mmp1Q273stop
Classical Alleles ( 19 )
For All Classical Alleles Show
Allele of Mmp1 Class Mutagen Stocks Known lesion Mmp1k04809 P-element activity 2 Yes Mmp1KG00484 2 -- Mmp15-HA-1685 1 -- Mmp1d03549 P-element activity 1 -- Mmp1d10601 P-element activity 1 -- Mmp1e01212 piggyBac transposase 1 -- Mmp1f03315 1 -- Mmp1f07923 piggyBac transposase 1 -- Mmp1MI03010 1 -- Mmp1MI03787 1 -- Mmp1Q112stop loss of function allele, amorphic allele ethyl methanesulfonate 0 Yes Mmp12 P-element activity 0 Yes Mmp13 P-element activity 0 Yes Mmp1D140 Delta2-3 0 Yes Mmp1Q273 0 -- Mmp1Q273stop hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Mmp1unspecified 0 -- Mmp1W208stop ethyl methanesulfonate 0 Yes Mmp1W439stop hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mmp1 Class Mutagen Stocks Known lesion Mmp1JF01336 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mmp1KK108894 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mmp1dsRNA.1.6kb in vitro construct - RNAi 0 -- Mmp1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Mmp1E225A.f1.MtnA in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes Mmp1E225A.f1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - site directed mutagenesis 0 Yes Mmp1E225A.f2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Mmp1F1.C93A.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes Mmp1f1.Scer\UAS in vitro construct - regulatory fusion 0 Yes Mmp1F2.C93A.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes Mmp1f2.Scer\UAS in vitro construct - regulatory fusion 0 Yes Mmp1F2.Scer\UAS in vitro construct - regulatory fusion 0 Yes Mmp1GD2216 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mmp1NIG.4859R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mmp1Pro-pex.f1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes Mmp1Pro-pex.f2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes Mmp1T:Avic\GFP in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2R)bwVDe2LPxKR (Spradling et al., 1999) Df(2R)Px2 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)Pof-D140 (Johansson et al., 2007)
Disrupted in	Df(2R)BSC606 (Christensen et al., 2008.9.3)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2216} NA P{KK108894} NA P{NIG.4859R} NA P{TRiP.JF01336} NA P{UAS-Mmp1.E225A.f2} NA P{UAS-Mmp1.F1.C93A} NA P{UAS-Mmp1.f1} NA P{UAS-Mmp1.F2.C93A} NA P{UAS-Mmp1.F2} NA P{UAS-Mmp1.f2} NA P{UAS-Mmp1.Pro-pex.f1} NA P{UAS-Mmp1.Pro-pex.f2} NA P{UAS-Mmp1.RNAi} NA reporter construct P{Mmp1-lacZ.U} No characterization construct P{Mmp1.GFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Mmp1k04809 No miscellaneous insertions Mi{MIC}Mmp1MI03010 NA Mi{MIC}Mmp1MI03787 NA P{RS5}Mmp15-HA-1685 NA P{SUPor-P}Mmp1KG00484 NA PBac{RB}Mmp1e01212 NA PBac{WH}Mmp1f03315 NA PBac{WH}Mmp1f07923 NA insertion of mobile activating element P{XP}Mmp1d03549 NA P{XP}Mmp1d10601 NA
Gene Ontology: Function, Process & Cellular Component ( 20 unique terms )
Terms Based on Experimental Evidence ( 15 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) basement membrane disassembly inferred from mutant phenotype (Srivastava et al., 2007) basement membrane organization inferred from mutant phenotype (Stevens and Page-McCaw, 2012) cell adhesion inferred from genetic interaction with NijA (Zhang et al., 2006) dorsal trunk growth, open tracheal system inferred from mutant phenotype (Page-McCaw et al., 2003) extracellular matrix organization inferred from mutant phenotype (Glasheen et al., 2010) imaginal disc eversion inferred from mutant phenotype (Srivastava et al., 2007, Glasheen et al., 2009) instar larval development inferred from mutant phenotype (Page-McCaw et al., 2003) molting cycle, chitin-based cuticle inferred from mutant phenotype (Glasheen et al., 2010) open tracheal system development inferred from mutant phenotype (Page-McCaw et al., 2002, Uhlirova and Bohmann, 2006) regulation of tube length, open tracheal system inferred from mutant phenotype (Glasheen et al., 2009) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003) tissue regeneration inferred from expression pattern (McClure et al., 2008) inferred from mutant phenotype (McClure et al., 2008) wound healing inferred from mutant phenotype (Stevens and Page-McCaw, 2012)
Cellular Component
CV term Evidence References
dendrite inferred from mutant phenotype (Kuo et al., 2005)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
calcium ion binding inferred from electronic annotation with InterPro:IPR016293 (FlyBase Curators et al., 2004-) metalloendopeptidase activity inferred from sequence or structural similarity with EMBL:AB010921 (FlyBase, 1992-) non-traceable author statement (Llano, 2000.5.24) zinc ion binding inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR016293, InterPro:IPR021190 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR006026, InterPro:IPR016293, InterPro:IPR021190 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
extracellular matrix inferred from electronic annotation with InterPro:IPR001818, InterPro:IPR021190 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mmp1 allele Gene References Mmp1f1.Scer\UAS Timp (Page-McCaw et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63521 DroID - A comprehensive database of gene and protein interactions. • FBgn0035049 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37949
Orthologs
OrthoDB Orthologs (175) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G7CHW Dipteran inclusive ortholog search EOG6R50B0 Insect inclusive ortholog search EOG67WMHT Arthropod inclusive ortholog search EOG68932J Metazoa inclusive ortholog search EOG6BKHX2
Orthologs in Drosophila Species (EOG6G7CHW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Mmp1     Drosophila simulans   Dsim\GD24926 Y   Drosophila sechellia   Dsec\GM11800 Y   Drosophila erecta   Dere\GG19900 Y   Drosophila yakuba   Dyak\GE11424 Y   Drosophila ananassae   Dana\GF11910 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18484 Y   Drosophila persimilis   Dper\GL17167 Y   Drosophila willistoni   Dwil\GK21871 Y   Drosophila virilis   Dvir\GJ21109 Y   Drosophila mojavensis   Dmoj\GI19538 Y   Drosophila grimshawi   Dgri\GH21566 Y
Orthologs in non-Drosophila Dipterans (EOG6R50B0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005666   Anopheles gambiae Malaria mosquito  Agam\AGAP006904   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010856
Orthologs in non-Dipteran Insects (EOG67WMHT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55889   Apis mellifera Western honey bee  Amel\GB40856   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037231   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13608   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13198   Atta cephalotes Leafcutter ant  Acep\ACEP16898   Atta cephalotes Leafcutter ant  Acep\ACEP12398   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12929   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20326   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19894   Linepithema humile Argentine ant  Lhum\LH18931   Linepithema humile Argentine ant  Lhum\LH21449   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15858   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12544   Solenopsis invicta Red fire ant  Sinv\SINV10477   Solenopsis invicta Red fire ant  Sinv\SINV23675   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005053   Bombyx mori Silkmoth  Bmor\BGIBMGA002885   Bombyx mori Silkmoth  Bmor\BGIBMGA007804   Pediculus humanus Human body louse  Phum\PHUM302710   Tribolium castaneum Red flour beetle  Tcas\Mmp1
Orthologs in non-Insect Arthropods (EOG68932J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_303491   Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\JGI_V11_229419   Daphnia pulex Water flea  Dpux\COI   Ixodes scapularis Deer tick  Isca\ISCW006136
Orthologs in non-Arthropod Metazoa (EOG6BKHX2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\zmp-1 Y Caenorhabditis elegans Nematode  Cele\H36L18.1 Y Caenorhabditis elegans Nematode  Cele\H19M22.3 Y Caenorhabditis elegans Nematode  Cele\T21D11.1 Y Caenorhabditis elegans Nematode  Cele\C31B8.8 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005576gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002029gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013670gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018472gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027328gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027604gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005723gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018156gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005385gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024003gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013669gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009925gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005577gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028749gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025345gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003703gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007980gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006014gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012549gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009924gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019540gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028748gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000567gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000566gn Y Danio rerio Zebrafish  Drer\CR848664.1 Y Danio rerio Zebrafish  Drer\mmp24 Y Danio rerio Zebrafish  Drer\ENSDARG00000013072 Y Danio rerio Zebrafish  Drer\CABZ01030094.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000077290 Y Danio rerio Zebrafish  Drer\mmp14a Y Danio rerio Zebrafish  Drer\CABZ01029422.1 Y Danio rerio Zebrafish  Drer\ENSDARG00000087801 Y Danio rerio Zebrafish  Drer\mmp13b Y Danio rerio Zebrafish  Drer\mmp16b Y Danio rerio Zebrafish  Drer\ENSDARG00000089887 Y Danio rerio Zebrafish  Drer\mmp14b Y Danio rerio Zebrafish  Drer\mmp16a Y Danio rerio Zebrafish  Drer\ENSDARG00000059029 Y Danio rerio Zebrafish  Drer\mmp11b Y Danio rerio Zebrafish  Drer\ENSDARG00000051962 Y Danio rerio Zebrafish  Drer\OTTDARG00000028175 Y Danio rerio Zebrafish  Drer\ENSDARG00000091557 Y Danio rerio Zebrafish  Drer\mmp17a Y Danio rerio Zebrafish  Drer\mmp13a Y Danio rerio Zebrafish  Drer\mmp11a Y Xenopus tropicalis Western clawed frog  Xtro\mmp28 Y Xenopus tropicalis Western clawed frog  Xtro\mmp11 Y Xenopus tropicalis Western clawed frog  Xtro\mmp3 Y Xenopus tropicalis Western clawed frog  Xtro\mmp24 Y Xenopus tropicalis Western clawed frog  Xtro\mmp8 Y Xenopus tropicalis Western clawed frog  Xtro\mmp16 Y Xenopus tropicalis Western clawed frog  Xtro\mmp25 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031108 Y Xenopus tropicalis Western clawed frog  Xtro\mmp14 Y Xenopus tropicalis Western clawed frog  Xtro\mmp13l Y Xenopus tropicalis Western clawed frog  Xtro\mmp1 Y Xenopus tropicalis Western clawed frog  Xtro\mmp17 Y Xenopus tropicalis Western clawed frog  Xtro\mmp19 Y Xenopus tropicalis Western clawed frog  Xtro\mmp13 Y Xenopus tropicalis Western clawed frog  Xtro\mmp15 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031177 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000034187 Y Gallus gallus Domestic chicken  Ggal\MMP11 Y Gallus gallus Domestic chicken  Ggal\MMP28 Y Gallus gallus Domestic chicken  Ggal\MMP16 Y Gallus gallus Domestic chicken  Ggal\MMP17 Y Gallus gallus Domestic chicken  Ggal\MMP3 Y Gallus gallus Domestic chicken  Ggal\MMP7 Y Gallus gallus Domestic chicken  Ggal\MMP27 Y Gallus gallus Domestic chicken  Ggal\MMP1 Y Gallus gallus Domestic chicken  Ggal\MMP13 Y Gallus gallus Domestic chicken  Ggal\MMP15 Y Gallus gallus Domestic chicken  Ggal\MMP24 Y Mus musculus House mouse  Mmus\Mmp25 Y Mus musculus House mouse  Mmus\Mmp15 Y Mus musculus House mouse  Mmus\Mmp13 Y Mus musculus House mouse  Mmus\Mmp1a Y Mus musculus House mouse  Mmus\Mmp27 Y Mus musculus House mouse  Mmus\Mmp24 Y Mus musculus House mouse  Mmus\Mmp10 Y Mus musculus House mouse  Mmus\Mmp17 Y Mus musculus House mouse  Mmus\Mmp11 Y Mus musculus House mouse  Mmus\Mmp8 Y Mus musculus House mouse  Mmus\Mmp28 Y Mus musculus House mouse  Mmus\Mmp1b Y Mus musculus House mouse  Mmus\Mmp7 Y Mus musculus House mouse  Mmus\Mmp16 Y Mus musculus House mouse  Mmus\Mmp19 Y Mus musculus House mouse  Mmus\Mmp14 Y Mus musculus House mouse  Mmus\Mmp20 Y Mus musculus House mouse  Mmus\Mmp3 Y Rattus norvegicus Norway rat  Rnor\Mmp15 Y Rattus norvegicus Norway rat  Rnor\Mmp1b Y Rattus norvegicus Norway rat  Rnor\Mmp10 Y Rattus norvegicus Norway rat  Rnor\Mmp8 Y Rattus norvegicus Norway rat  Rnor\Mmp17 Y Rattus norvegicus Norway rat  Rnor\Mmp3 Y Rattus norvegicus Norway rat  Rnor\Mmp28 Y Rattus norvegicus Norway rat  Rnor\Mmp19 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029621 Y Rattus norvegicus Norway rat  Rnor\Mmp7 Y Rattus norvegicus Norway rat  Rnor\Mmp27 Y Rattus norvegicus Norway rat  Rnor\Mmp20 Y Rattus norvegicus Norway rat  Rnor\Mmp14 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005708 Y Rattus norvegicus Norway rat  Rnor\Mmp12 Y Rattus norvegicus Norway rat  Rnor\Mmp13 Y Rattus norvegicus Norway rat  Rnor\Mmp1a Y Rattus norvegicus Norway rat  Rnor\Mmp11 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043133 Y Homo sapiens Human  Hsap\MMP7 Y Homo sapiens Human  Hsap\MMP8 Y Homo sapiens Human  Hsap\MMP12 Y Homo sapiens Human  Hsap\MMP19 Y Homo sapiens Human  Hsap\MMP11 Y Homo sapiens Human  Hsap\MMP13 Y Homo sapiens Human  Hsap\MMP3 Y Homo sapiens Human  Hsap\MMP16 Y Homo sapiens Human  Hsap\MMP26 Y Homo sapiens Human  Hsap\MMP27 Y Homo sapiens Human  Hsap\MMP24 Y Homo sapiens Human  Hsap\MMP28 Y Homo sapiens Human  Hsap\MMP14 Y Homo sapiens Human  Hsap\MMP20 Y Homo sapiens Human  Hsap\MMP17 Y Homo sapiens Human  Hsap\MMP1 Y Homo sapiens Human  Hsap\MMP15 Y Homo sapiens Human  Hsap\MMP10 Y Homo sapiens Human  Hsap\MMP25 Y
Human Orthologs (19)
Gene OMIM HGNC Hsap\MMP7     Hsap\MMP8     Hsap\MMP12     Hsap\MMP19     Hsap\MMP11     Hsap\MMP13     Hsap\MMP3     Hsap\MMP16     Hsap\MMP26     Hsap\MMP27     Hsap\MMP24     Hsap\MMP28     Hsap\MMP14     Hsap\MMP20     Hsap\MMP17     Hsap\MMP1     Hsap\MMP15     Hsap\MMP10     Hsap\MMP25
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24926 Drosophila sechellia Dsec\GM11800 Drosophila erecta Dere\GG19900 Drosophila yakuba Dyak\GE11424 Drosophila ananassae Dana\GF11910 Drosophila pseudoobscura pseudoobscura Dpse\GA18484 Drosophila persimilis Dper\GL17167 Drosophila willistoni Dwil\GK21871 Drosophila virilis Dvir\GJ21109 Drosophila mojavensis Dmoj\GI19538 Drosophila grimshawi Dgri\GH21566
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	31489 y1 v1; P{TRiP.JF01336}attP2 35918 y1 w*; Mi{MIC}Mmp1MI03010 37224 y1 w*; Mi{MIC}Mmp1MI03787 12205 y1 w67c23; P{lacW}Mmp1k04809/CyO 13673 y1; P{SUPor-P}Mmp1KG00484/SM6a; ry506
Harvard	- P{XP}Mmp1d03549 - P{XP}Mmp1d10601 - PBac{RB}Mmp1e01212 - PBac{WH}Mmp1f03315 - PBac{WH}Mmp1f07923
Kyoto	125344 w1118; P{RS5}Mmp15-HA-1685
VDRC	v101505 P{KK108894}VIE-260B
	More stocks available...
Genomic Clones ( 2 )
	BACR03I24 BACR27P17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE19818 RE62222
Other clones	FI01410 MIP15906
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP02595 RH22088 RH23928 RH23945
Other clones	11551 11854 72734 78234 155604 211244.1 214279.45 214287.63 214543.69 522424 524102 524786 542686 542882 572875 CK01.60A.C5 CK01.71B.E6 Dmel_dig_013222_0714_1636 EC26466 EK056651 EK063311 EK112034 EK112035 EK136104 EK201343 EK211642 EK258749 EK302808 EN02012 EN04751 EN05927 EN11117 EN11535 EN11751 EN17248 EP12227 EP20029 ESG011b.E7_E07 ESG011b.E21_E07 FGM304G07 RP004056011 RP004139072 RP004139673 RP004164383 RP004197314 RP004207131 RP004210914 RP004219020 RP004251905 RP004255749 RP004256896 RP004353950 RP004382285 RP004430268 RP004474924 RP004539561
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035049 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37949
Antibody Information
	monoclonal (Page-McCaw et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mmp1 CG4859 (Llano et al., 2000) Source for identity of: MMP CG4859 (FlyBase, 1996-)
Source for database merge of	Source for merge of: Mmp1 l(2)k04809 (Page-McCaw et al., 2003)
Additional comments	Source for identity of MMP CG4859 was sequence comparison (date:001123). (FlyBase, 1996-)
Other Comments
	Mmp1 delimits imaginal disc regeneration by regulating the cell-cycle arrest of non-blastema cells. (McClure et al., 2008) The last 40 amino acid residues of Mmp1 are necessary for a strong interaction with NijA. (Zhang et al., 2006) NijA and Mmp1 proteins can form a stable complex. (Zhang et al., 2006) Mmp1 expression is required for NijA-induced loss of adhesion. (Zhang et al., 2006) Mutants are larval lethal with defects in the tracheal system. (Page-McCaw et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079128 NM_166683 NM_001202070 NM_001202071 NM_001202072 NM_001202073 NM_001202074 NM_001202075 NM_001202076 NM_001259570 RefSeq (Proteins) • NP_523852 NP_726473 NP_001188999 NP_001189000 NP_001189001 NP_001189002 NP_001189003 NP_001189004 NP_001189005 NP_001246499 DDBJ / EMBL / GenBank • AAF47255 AAG33131 AAM48434 AAM68327 AAX33451 ADV37245 ADV37246 ADV37247 ADV37248 ADV37249 ADV37250 ADV37251 AF271666 AFH08252 AQ025748 AY118405 BI374588 BT021303 CZ473420 CZ477342 CZ479020 CZ490646 Entrez Gene - A searchable database of RefSeq genes. • 37949 UniProtKB/TrEMBL • Q8MLN6 Q9GTK3 Q9W122
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Hemopexin, conserved site (IPR018486) Hemopexin-like repeats (IPR018487) Hemopexin-like domain (IPR000585) Peptidase M10, metallopeptidase (IPR001818) Peptidoglycan binding-like (IPR002477) Peptidase, metallopeptidase (IPR006026) Peptidase M10A, metazoans (IPR016293) Metallopeptidase, catalytic domain (IPR024079) Peptidase M10A (IPR021190) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE62222
Linkouts
	BioGRID - A database of protein and genetic interactions • 63521 DroID - A comprehensive database of gene and protein interactions. • FBgn0035049 DRSC - Results from RNAi screens. • FBgn0035049 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035049 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4859-RA;CG4859-RB;CG4859-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035049 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37949 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37949 modMine - Data generated by the modENCODE project. • FBgn0035049
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	CG4859 (Klebes et al., 2005, Lee et al., 2003, Boutros et al., 2002, Llano, 2000.5.24, Coates et al., 2000, Gorski et al., 2003, Valanne et al., 2007, Mosallanejad et al., 2010, Carrera et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2008, Johansson et al., 2005) dm1-MMP (Wei et al., 2003) Dm1-MMP (McFarlane, 2003, Llano et al., 2002, Llano, 2000.5.24, Llano et al., 2000) dmmp1 (Vidal et al., 2010, Singh et al., 2010) dMMP1 (Read et al., 2009, Cordero et al., 2010) l(2)k04809 (Page-McCaw et al., 2003, Spradling et al., 1999, ) Mmp1 (Sun et al., 2012, Page-McCaw et al., 2007, Glasheen et al., 2007, Zhang et al., 2006, Uhlirova and Bohmann, 2006, Meyer and Aberle, 2006, Sustar et al., 2008, Christensen et al., 2008.9.3, Zeitouni et al., 2007, Kadener et al., 2007, Menut et al., 2007, Srivastava et al., 2007, Miller et al., 2011, Neisch et al., 2010, Waldholm et al., 2011, Johansson et al., 2007, Miller et al., 2008, Beaucher et al., 2007, McClure et al., 2008, Morrison et al., 2008, Glasheen et al., 2009, Kadener et al., 2009, Carrera et al., 2008, Graham et al., 2009, Guha et al., 2009, Schmidt et al., 2011, Windler and Bilder, 2010, Yasunaga et al., 2010, Glasheen et al., 2010, Vaccari et al., 2010, Page-McCaw et al., 2003, Padash-Barmchi et al., 2010, Japanese National Institute of Genetics, 2012.5.21, Stevens and Page-McCaw, 2012, Gurudatta et al., 2012) mmp1 (Uhlirova and Bohmann, 2006, Wang et al., 2010, Siekhaus et al., 2010, Zhang and Arnosti, 2011, Zhang et al., 2011) MMP1 (Bakal et al., 2008, Rodahl et al., 2009, Gesellchen et al., 2005, Warner et al., 2010, Jiang et al., 2011, Bangi et al., 2012, Meyer et al., 2011) MMP-1 (Classen et al., 2009) Mmp 1 (Johansson et al., 2005) MMp1 (Pallavi et al., 2012)
Name Synonym	Matrix metalloprotease 1 (Vaccari et al., 2010) matrix metalloprotease 1 (Morrison et al., 2008, Rodahl et al., 2009) Matrix metalloproteinase 1 (Llano, 2000.5.24, Neisch et al., 2010, Gesellchen et al., 2005, Padash-Barmchi et al., 2010) Matrix Metalloproteinase 1 (Sustar et al., 2008) Matrix metalloproteinase-1 (McClure et al., 2008) matrix metalloproteinase 1 (Wang et al., 2010) Matrix metalloproteinase1 (Felix et al., 2012)
Secondary FlyBase IDs
	FBgn0022198
References ( 98 )
Generate a list of	All references relating to this gene ( 98 )
List References by type	Research paper  ( 70 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 19 )
	Rudrapatna et al., 2013, EMBO Rep. 14(2): 172--177 Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion. [FBrf0220676] Bangi et al., 2012, EMBO Rep. 13(6): 569--576 Immune response to bacteria induces dissemination of Ras-activated Drosophila hindgut cells. [FBrf0218473] Dekanty et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(50): 20549--20554 Aneuploidy-induced delaminating cells drive tumorigenesis in Drosophila epithelia. [FBrf0220285] Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Gilchrist et al., 2012, Genes Dev. 26(9): 933--944 Regulating the regulators: the pervasive effects of Pol II pausing on stimulus-responsive gene networks. [FBrf0218258] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Herranz et al., 2012, Curr. Biol. 22(8): 651--657 Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. [FBrf0220229] Pallavi et al., 2012, EMBO J. 31(13): 2895--2907 Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. [FBrf0218851] Stevens and Page-McCaw, 2012, Mol. Biol. Cell 23(6): 1068--1079 A secreted MMP is required for reepithelialization during wound healing. [FBrf0217752] Sun et al., 2012, PLoS Genet. 8(2): e1002515 Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants. [FBrf0217508] Bond et al., 2011, Dev. Biol. 360(2): 286--296 ßFTZ-F1 and Matrix metalloproteinase 2 are required for fat-body remodeling in Drosophila. [FBrf0216600] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Miller et al., 2011, J. Neurosci. 31(14): 5335--5347 Drosophila mmp2 regulates the matrix molecule faulty attraction (frac) to promote motor axon targeting in Drosophila. [FBrf0213409] Robinson and Moberg, 2011, Cell Cycle 10(23): 4110--4118 Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway. [FBrf0217243] Schmidt et al., 2011, Self Nonself 2(3): 125--141 Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. [FBrf0218028] Siller and Broadie, 2011, Dis. Model Mech. 4(5): 673--685 Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. [FBrf0215041] Waldholm et al., 2011, BMC Mol. Biol. 12: 46 SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster. [FBrf0216757] Zhang and Arnosti, 2011, Mol. Cell. Biol. 31(2): 375--384 Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development. [FBrf0212606] Zhang et al., 2011, Chromosoma 120(1): 97--108 Drosophila melanogaster heterochromatin protein HP1b plays important roles in transcriptional activation and development. [FBrf0212898] Show all research papers ...
Recent reviews ( 1 )
	Meyer et al., 2011, Europ. J. Cell Biol. 90(9): 770--778 Drosophila metalloproteases in development and differentiation: The role of ADAM proteins and their relatives. [FBrf0214506] Show all reviews ...