MMP-1, dMMP1, l(2)k04809, Dm1-MMP, matrix metalloprotease 1
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mmp1 using the Feature Mapper tool.
Mmp1 expression is activated in prothoracic leg discs after regeneration is induced. It is expressed along the ventral cut site, where the blastema forms, and along the dorsal cut site.
The expression of this gene along with several others is induced in salivary glands in pupae at the time of head eversion. This stage is characterized by an increase in the ecdysone titer as well as large amounts of cell death in this tissue.
Mmp1 is expressed in embryos beginning at stage 13. It is expressed in segmentally repeating cells associated with the migrating dorsal epithelium before dorsal closure. It is also expressed at the site of dorsal closure at stage 15. Staining is observed in the ventral midline and in the proventriculus starting at stage 14, in the posterior spiracles at stage 14, and in the hindgut at stage 16. In wandering third instar larvae, expression is observed in the wing disc in a band of cells proximal to the wing hinge, forming a line from the posterior side to the middle of the disc. This band is thought to be the migrating primordia of the adult tracheal airsac. No expression is seen in the leg or eye-antennal discs.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mmp1 in GBrowse 2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Mmp1 delimits imaginal disc regeneration by regulating the cell-cycle arrest of non-blastema cells.
Mutants are larval lethal with defects in the tracheal system.