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Gene Dmel\Eap

General Information
Symbol	Dmel\Eap	Species	D. melanogaster
Name	Exu-associated protein	Annotation symbol	CG3594
Feature type	protein_coding_gene	FlyBase ID	FBgn0035063
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	60E1-60E1	Sequence location	2R:20,668,468..20,669,307 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Exu-associated protein is referred to in FlyBase by the symbol Dmel\Eap (CG3594, FBgn0035063). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: mRNA binding. The biological processes in which it is involved are not known. 3 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1626337_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Eap. Gene sequence location is 2R:20668468..20669307.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA04393 BKN26864
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 60E1-60E1   Limits computationally determined from genome sequence between P{lacW}Mmp1k04809 and P{EP}Reg-5EP1065
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Eap for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Eap-RA FBtr0072374  NM_079131   840   250
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Eap-PA   FBpp0072281   28.2   250   9.47     NP_523855   AAF47270
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF47270   AI456155   AW943315   AY094823 AAM11176   BI142004   BI352727   BI352797   BI354587   BT023881   BT030793   EC221025   EV581932   EV583310   EV597472
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8SX67 Q9W108
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035063    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035063 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035063 expression level Developmental Stage   Expression Level embryo 00-02hr    2495 embryo 02-04hr    2838 embryo 04-06hr    2754 embryo 06-08hr    3683 embryo 08-10hr    3584 embryo 10-12hr    3049 embryo 12-14hr    2426 embryo 14-16hr    1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr    3001 embryo 22-24hr    2542 larva L1    3315 larva L2    1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day    2045 adult female 30day    2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2495) embryo 02-04hr  (2838) embryo 04-06hr  (2754) embryo 06-08hr  (3683) embryo 08-10hr  (3584) embryo 10-12hr  (3049) embryo 12-14hr  (2426) embryo 14-16hr  (1541) embryo 16-18hr  (1373) embryo 18-20hr  (975) embryo 20-22hr  (3001) embryo 22-24hr  (2542) larva L1  (3315) larva L2  (1951) larva L3 12hr old  (1137) larva L3 puffstage 1-2  (664) larva L3 puffstage 3-6  (824) larva L3 puffstage 7-9  (967) white prepupae new  (856) white prepupae 12hr  (884) white prepupae 24hr  (904) pupae 2d postWPP  (990) pupae 3d postWPP  (506) pupae 4d postWPP  (381) adult male 01day  (403) adult male 05day  (396) adult male 30day  (366) adult female 01day  (1269) adult female 05day  (2045) adult female 30day  (2169) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2495) embryo 02-04hr  (2838) embryo 04-06hr  (2754) embryo 06-08hr  (3683) embryo 08-10hr  (3584) embryo 10-12hr  (3049) embryo 12-14hr  (2426) embryo 14-16hr  (1541) embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr  (3001) embryo 22-24hr  (2542) larva L1  (3315) larva L2  (1951) larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day  (2045) adult female 30day  (2169) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2495 embryo 02-04hr    2838 embryo 04-06hr    2754 embryo 06-08hr    3683 embryo 08-10hr    3584 embryo 10-12hr    3049 embryo 12-14hr    2426 embryo 14-16hr    1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr    3001 embryo 22-24hr    2542 larva L1    3315 larva L2    1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day    2045 adult female 30day    2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2495 embryo 02-04hr    2838 embryo 04-06hr    2754 embryo 06-08hr    3683 embryo 08-10hr    3584 embryo 10-12hr    3049 embryo 12-14hr    2426 embryo 14-16hr    1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr    3001 embryo 22-24hr    2542 larva L1    3315 larva L2    1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day    2045 adult female 30day    2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035063 expression level Developmental Stage   Expression Level embryo 00-02hr    2495 embryo 02-04hr    2838 embryo 04-06hr    2754 embryo 06-08hr    3683 embryo 08-10hr    3584 embryo 10-12hr    3049 embryo 12-14hr    2426 embryo 14-16hr    1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr    3001 embryo 22-24hr    2542 larva L1    3315 larva L2    1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day    2045 adult female 30day    2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2495) embryo 02-04hr  (2838) embryo 04-06hr  (2754) embryo 06-08hr  (3683) embryo 08-10hr  (3584) embryo 10-12hr  (3049) embryo 12-14hr  (2426) embryo 14-16hr  (1541) embryo 16-18hr  (1373) embryo 18-20hr  (975) embryo 20-22hr  (3001) embryo 22-24hr  (2542) larva L1  (3315) larva L2  (1951) larva L3 12hr old  (1137) larva L3 puffstage 1-2  (664) larva L3 puffstage 3-6  (824) larva L3 puffstage 7-9  (967) white prepupae new  (856) white prepupae 12hr  (884) white prepupae 24hr  (904) pupae 2d postWPP  (990) pupae 3d postWPP  (506) pupae 4d postWPP  (381) adult male 01day  (403) adult male 05day  (396) adult male 30day  (366) adult female 01day  (1269) adult female 05day  (2045) adult female 30day  (2169) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2495) embryo 02-04hr  (2838) embryo 04-06hr  (2754) embryo 06-08hr  (3683) embryo 08-10hr  (3584) embryo 10-12hr  (3049) embryo 12-14hr  2426 embryo 14-16hr  1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr  (3001) embryo 22-24hr  (2542) larva L1  (3315) larva L2  1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day  2045 adult female 30day  2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2495 embryo 02-04hr    2838 embryo 04-06hr    2754 embryo 06-08hr    3683 embryo 08-10hr    3584 embryo 10-12hr    3049 embryo 12-14hr    2426 embryo 14-16hr    1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr    3001 embryo 22-24hr    2542 larva L1    3315 larva L2    1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day    2045 adult female 30day    2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2495 embryo 02-04hr    2838 embryo 04-06hr    2754 embryo 06-08hr    3683 embryo 08-10hr    3584 embryo 10-12hr    3049 embryo 12-14hr    2426 embryo 14-16hr    1541 embryo 16-18hr    1373 embryo 18-20hr    975 embryo 20-22hr    3001 embryo 22-24hr    2542 larva L1    3315 larva L2    1951 larva L3 12hr old    1137 larva L3 puffstage 1-2    664 larva L3 puffstage 3-6    824 larva L3 puffstage 7-9    967 white prepupae new    856 white prepupae 12hr    884 white prepupae 24hr    904 pupae 2d postWPP    990 pupae 3d postWPP    506 pupae 4d postWPP    381 adult male 01day    403 adult male 05day    396 adult male 30day    366 adult female 01day    1269 adult female 05day    2045 adult female 30day    2169 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035063    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035063 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval trachea, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035063 expression level Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035063 expression level Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    92.275 Larval Midgut    23.1 Larval Hindgut    38.9 Larval Malpighian Tubules no informative data Larval Fat Body    6.4 Larval Salivary Gland    68.9 Larval Trachea    110.2 Larval Carcass    51.45 Adult Head    31.9 Adult Eye    45.325 Adult Brain    38.8 Adult Thoracic-Abdominal Ganglion    27.1 Adult Crop    28.7 Adult Midgut    25.6 Adult Hindgut    24 Adult Malpighian Tubules no informative data Adult Fat Body    37 Adult Salivary Gland no informative data Adult Heart    40.1 Adult VirginFemale Spermatheca    5.2 Adult InseminatedFemale Spermatheca no informative data Adult Ovary    101.8 Adult Testis    9.8 Adult Male Accessory Gland    130 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    31.9   NA  Eye    45.325   NA  Brain    38.8   92.275  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    27.1   NA  Crop    28.7   23.1  Midgut    25.6   38.9  Hindgut    24   no informative data  Malpighian Tubules    no informative data   6.4  Fat Body    37   68.9  Salivary Gland    no informative data   NA  Heart    40.1   110.2  Trachea    NA   NA  VirginFemale Spermatheca    5.2   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    101.8   NA  Testis    9.8   NA  Male Accessory Gland    130   51.45  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035063 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3594-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 EapGD11024 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 EapGD11024 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 EapGD11024
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Eap Class Mutagen Stocks Known lesion EapEY01992 P-element activity 2 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Eap Class Mutagen Stocks Known lesion EapGD11024 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes EapKK106864 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11024} NA P{KK106864} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}EapEY01992 NA P{GSV1}EP-284EP-284 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR000504 (FlyBase Curators et al., 2004-) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Eap allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63534 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035063 DroID - A comprehensive database of gene and protein interactions. • FBgn0035063 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37964
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13340 Dere\GG23005 Dgri\GH20357 Dmoj\GI20026 Dper\GL16773 Dpse\GA17545 Dsec\GM11898 Dsim\GD11896 Dvir\GJ21274 Dwil\GK21670 Dyak\GE14442
Curated drosophilid orthologs	Dpse\GA17545
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001997-PA Aedes aegypti (mosquito) AGAP009179-PA Anopheles gambiae (mosquito) XP_001122335.1 Apis mellifera (honey bee) CAL0000479 Candida albicans (a form of yeast) cn04385 Cryptococcus neoformans (yeast-like fungus) CPIJ012605 Culex pipens (mosquito) DEHA2F03630g Debaryomyces Hansenii (yeast) 98779 Daphnia pulex (daphnia) XP_654300 Entamoeba histolytica (anaerobic protozoan) 167525 Hypsipyla robusta (cedar shoot borer) 196728 Nematostella vectensis (starlet anemone) SPBC365.04c Schizosaccharomyces pombe (fission yeast) 20814 Thalassiosira pseudonana (marine diatom) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13529 NV12901 LH25427 FBgn0232048 FBgn0223655 FBgn0208406 FBgn0183635 FBgn0166839 JGI_V11_98779 FBgn0077556 FBgn0154377 FBgn0142762 FBgn0127820 FBgn0115162 FBgn0090372 CPIJ012605 BGIBMGA009685 GB16175 AGAP009179 AAEL001997 GLEAN_09936
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	15847 y1 w67c23; P{EPgy2}EapEY01992/CyO
Kyoto	114419 yd2 w1118 P{ey-FLP.N}2; P{neoFRT}42D P{EPgy2}EapEY01992 /CyO y+
VDRC	v106734 P{KK106864}VIE-260B v26246 w1118; P{GD11024}v26246 v26248 w1118; P{GD11024}v26248/CyO
Genomic Clones ( 1 )
	BACR27P17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD36016 RE64541
Other clones	DPiM_FI01540 FI01540
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM20527 GM20844 GM27513 SD15989
Other clones	14708 Dmel_dig_007338_0711_1297 Dmel_dig_019501_0653_1537 Dmel_neb_009813_0889_0289
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035063 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37964
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Eap CG3594 (Hazelrigg, 2001.3.12)
Source for database merge of
Additional comments
Other Comments
	Identification: in a yeast two-hybrid screen for proteins that bind to exu protein. (Moon et al., 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079131 RefSeq (Proteins) • NP_523855 DDBJ / EMBL / GenBank • AAF47270 AAM11176 AI456155 AW943315 AY094823 Entrez Gene - A searchable database of RefSeq genes. • 37964 UniProtKB/TrEMBL • Q8SX67 Q9W108
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63534 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035063 DroID - A comprehensive database of gene and protein interactions. • FBgn0035063 DRSC - Results from RNAi screens. • FBgn0035063 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035063 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3594-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035063 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37964 InParanoid A subset of ortholog calls from InParanoid. • AAEL001997-PA Aedes aegypti (mosquito) AGAP009179-PA Anopheles gambiae (mosquito) XP_001122335.1 Apis mellifera (honey bee) CAL0000479 Candida albicans (a form of yeast) cn04385 Cryptococcus neoformans (yeast-like fungus) CPIJ012605 Culex pipens (mosquito) DEHA2F03630g Debaryomyces Hansenii (yeast) 98779 Daphnia pulex (daphnia) XP_654300 Entamoeba histolytica (anaerobic protozoan) 167525 Hypsipyla robusta (cedar shoot borer) 196728 Nematostella vectensis (starlet anemone) SPBC365.04c Schizosaccharomyces pombe (fission yeast) 20814 Thalassiosira pseudonana (marine diatom) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37964 modMine - Data generated by the modENCODE project. • FBgn0035063 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13529 NV12901 LH25427 FBgn0232048 FBgn0223655 FBgn0208406 FBgn0183635 FBgn0166839 JGI_V11_98779 FBgn0077556 FBgn0154377 FBgn0142762 FBgn0127820 FBgn0115162 FBgn0090372 CPIJ012605 BGIBMGA009685 GB16175 AGAP009179 AAEL001997 GLEAN_09936
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	cg3594 (Lasko, 2000) CG3594 (Molnar et al., 2006, Keleman et al., 2009.8.5) Eap (Molnar et al., 2006, Telonis-Scott et al., 2009)
Name Synonym	Exu-associated protein (Moon et al., 2001)
Secondary FlyBase IDs
References ( 17 )
Research paper	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Telonis-Scott et al., 2009, J. Insect Physiol. 55(6): 549--555 Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. [FBrf0208060] Molnar et al., 2006, Genetics 174(3): 1635--1659 A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. [FBrf0195387] Lasko, 2000, J. Cell Biol. 150(2): F51--F56 The Drosophila melanogaster genome: translation factors and RNA binding proteins. [FBrf0129923]
Supplementary material	Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Hazelrigg, 2001.3.12, Helping FlyBase: ADRC-10835. Helping FlyBase: ADRC-10835. [FBrf0135335]
Abstract	Moon et al., 2001, A. Dros. Res. Conf. 42: 611B Functional analysis of the Eap gene during Drosophila oogenesis. [FBrf0134204]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Lasko, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126679]