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Gene Dmel\Cypl

General Information
Symbol	Dmel\Cypl	Species	D. melanogaster
Name	Cyclophilin-like	Annotation symbol	CG13892
Feature type	protein_coding_gene	FlyBase ID	FBgn0035141
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	61C3-61C3	Sequence location	3L:542,122..542,931 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cyclophilin-like is referred to in FlyBase by the symbol Dmel\Cypl (CG13892, FBgn0035141). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peptidyl-prolyl cis-trans isomerase activity. It is reported to be involved in the biological process: regulation of post-mating oviposition; mRNA splicing, via spliceosome. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain; Cyclophilin-type peptidyl-prolyl cis-trans isomerase; Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1639357_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cypl. Gene sequence location is 3L:542122..542931.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 61C3-61C3   Limits computationally determined from genome sequence between P{EP}EP3104EP3104 and P{PZ}l(3)0596705967
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cypl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cypl-RA FBtr0072564  NM_079150   718   176
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cypl-PA   FBpp0072463   19.5   176   7.16     NP_523874   AAF47391
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain (IPR002130) Cyclophilin-type peptidyl-prolyl cis-trans isomerase (IPR024936) Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (IPR020892)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47391   AY070975 AAL48597   AY102656   BI167131   BI483039   BI574838   BI582616   CO277401   CO343163   EC197791   EC213208   EC259527
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W0Q2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    170.7 Larval Midgut    28.1 Larval Hindgut    45.7 Larval Malpighian Tubules    44.7 Larval Fat Body    54.4 Larval Salivary Gland    98.8 Larval Trachea    88.975 Larval Carcass    37.125 Adult Head    56 Adult Eye    80.275 Adult Brain    69.8 Adult Thoracic-Abdominal Ganglion    81.8 Adult Crop    57.8 Adult Midgut    45 Adult Hindgut    39.2 Adult Malpighian Tubules    33.1 Adult Fat Body    37.9 Adult Salivary Gland    35.4 Adult Heart    52.15 Adult VirginFemale Spermatheca    35.1 Adult InseminatedFemale Spermatheca    38.3 Adult Ovary    164.9 Adult Testis    50 Adult Male Accessory Gland    114.5 Adult Carcass    53.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    56   NA  Eye    80.275   NA  Brain    69.8   170.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    81.8   NA  Crop    57.8   28.1  Midgut    45   45.7  Hindgut    39.2   44.7  Malpighian Tubules    no informative data   54.4  Fat Body    no informative data   98.8  Salivary Gland    no informative data   NA  Heart    52.15   88.975  Trachea    NA   NA  VirginFemale Spermatheca    35.1   NA  InseminatedFemale Spermatheca    38.3   NA  Ovary    164.9   NA  Testis    50   NA  Male Accessory Gland    114.5   37.125  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    44 central nervous system, larvae L3    34 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (44) central nervous system, larvae L3  (34) central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  (29) ovary, mated 4-day female  26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    44 central nervous system, larvae L3    34 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    44 central nervous system, larvae L3    34 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    44 central nervous system, larvae L3    34 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (44) central nervous system, larvae L3  (34) central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female  29 ovary, mated 4-day female  26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    44 central nervous system, larvae L3    34 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    44 central nervous system, larvae L3    34 central nervous system, pupae P8    12 head, virgin 1-day female    4 head, virgin 4-day female    5 head, virgin 20-day female    4 head, mated 1-day female    4 head, mated 4-day female    5 head, mated 20-day female    5 head, mated 1-day male    6 head, mated 4-day male    6 head, mated 20-day male    9 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    7 digestive system, 20-day adult    7 fat body, larvae L3 wandering    3 fat body, white prepupae    7 fat body, pupae P8    13 carcass, larvae L3 wandering    20 carcass, 1-day adult    5 carcass, 4-day adult    8 carcass, 20-day adult    6 ovary, virgin 4-day female    29 ovary, mated 4-day female    26 testis, mated 4-day male    18 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    99 embryo 04-06hr    89 embryo 06-08hr    55 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    24 embryo 14-16hr    26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (99) embryo 04-06hr  (89) embryo 06-08hr  (55) embryo 08-10hr  (46) embryo 10-12hr  (36) embryo 12-14hr    24 embryo 14-16hr  26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr  (31) pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day  (30) adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    99 embryo 04-06hr    89 embryo 06-08hr    55 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    24 embryo 14-16hr    26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    99 embryo 04-06hr    89 embryo 06-08hr    55 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    24 embryo 14-16hr    26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    30 adult female 30day    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    99 embryo 04-06hr    89 embryo 06-08hr    55 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    24 embryo 14-16hr    26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (66) embryo 02-04hr  (99) embryo 04-06hr  (89) embryo 06-08hr  (55) embryo 08-10hr  (46) embryo 10-12hr  (36) embryo 12-14hr    24 embryo 14-16hr  26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr  31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day  30 adult female 30day  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    99 embryo 04-06hr    89 embryo 06-08hr    55 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    24 embryo 14-16hr    26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    66 embryo 02-04hr    99 embryo 04-06hr    89 embryo 06-08hr    55 embryo 08-10hr    46 embryo 10-12hr    36 embryo 12-14hr    24 embryo 14-16hr    26 embryo 16-18hr    16 embryo 18-20hr    11 embryo 20-22hr    17 embryo 22-24hr    14 larva L1    15 larva L2    21 larva L3 12hr old    16 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    22 white prepupae new    21 white prepupae 12hr    20 white prepupae 24hr    31 pupae 2d postWPP    20 pupae 3d postWPP    8 pupae 4d postWPP    8 adult male 01day    10 adult male 05day    14 adult male 30day    14 adult female 01day    21 adult female 05day    30 adult female 30day    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    22 embryonic 1182-4H    37 embryonic GM2    18 embryonic Kc167    40 embryonic S1    32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    35 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    70 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (52) Schneider line 2 Sg4    22 embryonic 1182-4H  (37) embryonic GM2    18 embryonic Kc167  (40) embryonic S1  (32) embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9  (27) wing disc ML-DmD16-c3  (28) wing disc ML-DmD21  (35) wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11  (30) antennal disc ML-DmD20-c5  (70) mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  (31) CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    22 embryonic 1182-4H    37 embryonic GM2    18 embryonic Kc167    40 embryonic S1    32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    35 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    70 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    22 embryonic 1182-4H    37 embryonic GM2    18 embryonic Kc167    40 embryonic S1    32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    35 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    70 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    22 embryonic 1182-4H    37 embryonic GM2    18 embryonic Kc167    40 embryonic S1    32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    35 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    70 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (52) Schneider line 2 Sg4    22 embryonic 1182-4H  (37) embryonic GM2    18 embryonic Kc167  (40) embryonic S1  32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9  27 wing disc ML-DmD16-c3  28 wing disc ML-DmD21  (35) wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11  30 antennal disc ML-DmD20-c5  (70) mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  31 CNS ML-DmBG2-c2  26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    22 embryonic 1182-4H    37 embryonic GM2    18 embryonic Kc167    40 embryonic S1    32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    35 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    70 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    52 Schneider line 2 Sg4    22 embryonic 1182-4H    37 embryonic GM2    18 embryonic Kc167    40 embryonic S1    32 embryonic S3    18 leg disc CME L1    20 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    27 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    35 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    70 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    26 tumorous blood cells mbn2    10 ovary fGS/OSS    18 ovary OSC    8 ovary OSS    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    13 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    14 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    17 Copper 0.5 mM 12 hrs, larvae L3    17 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    21 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    11 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • RE07451 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035141 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13892-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU CyplKK107406 viable, with Scer\GAL4pnr-MD237 CyplGD8156 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Cypl Class Mutagen Stocks Known lesion Cypl3 Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cypl Class Mutagen Stocks Known lesion CyplGD8156 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CyplKK107406 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CyplNIG.13892R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(3L)hipk3 (Lee et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8156} NA P{KK107406} NA P{NIG.13892R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{?'GT1}hipk3 NA P{GT1}hipkBG02654 NA insertion of mobile activating element P{EP}hipkEP3288 NA P{GSV1}EP-880EP-880 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
peptidyl-prolyl cis-trans isomerase activity inferred from sequence or structural similarity with UniProtKB:Q9DCY1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) protein folding inferred from electronic annotation with InterPro:IPR002130, InterPro:IPR020892 (FlyBase Curators et al., 2004-) regulation of post-mating oviposition non-traceable author statement (Nakayama and Aigaki, 2001)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Cypl - ATbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Atac1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Bub1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Bx42 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG10249 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG10417 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG10483 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG11679 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG12519 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG1271 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG13220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG13567 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG14195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG15014 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG15345 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG18011 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG2034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG30059 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG3714 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG43164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG4610 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG5080 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG5703 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG6674 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG6796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG7146 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG7239 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG7339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG7739 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG7945 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG8042 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG8671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG9389 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CG9394 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CalpA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CanB2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - CycC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Liprin-α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Lmpt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Lpin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Mob4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Obp49a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - P58IPK anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - PebIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Ras85D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - SNCF anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - ST6Gal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Sdc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Sesn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Stat92E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Synd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Tbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Tom anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - Vps25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - crn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - dlg1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - dome anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - dpn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - elB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - fzy anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - lok anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - msl-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - orb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - rap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - rn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - rnh1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - santa-maria anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Cypl - thoc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cypl allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0035141 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38069
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61JZZQ Dipteran inclusive ortholog search EOG61VKC7 Insect inclusive ortholog search EOG6M64F1 Arthropod inclusive ortholog search EOG6GB5PK Metazoa inclusive ortholog search EOG62ZHK7
Orthologs in Drosophila Species (EOG61JZZQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Cypl     Drosophila simulans   Dsim\GD25702 Y   Drosophila sechellia   Dsec\GM14273 Y   Drosophila erecta   Dere\GG14657 Y   Drosophila yakuba   Dyak\GE21017 Y   Drosophila ananassae   Dana\GF25039 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12606 Y   Drosophila persimilis   Dper\GL22598 Y   Drosophila willistoni   Dwil\GK20536 Y   Drosophila virilis   Dvir\GJ23427 Y   Drosophila mojavensis   Dmoj\GI22699 Y   Drosophila grimshawi   Dgri\GH21768 Y
Orthologs in non-Drosophila Dipterans (EOG61VKC7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007061   Anopheles gambiae Malaria mosquito  Agam\AGAP012376   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ014089
Orthologs in non-Dipteran Insects (EOG6M64F1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC727378   Apis mellifera Western honey bee  Amel\GB41018   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007087   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14172   Atta cephalotes Leafcutter ant  Acep\ACEP27170   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22856   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12588   Linepithema humile Argentine ant  Lhum\LH15158   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18725   Solenopsis invicta Red fire ant  Sinv\SINV21305   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003448   Bombyx mori Silkmoth  Bmor\BGIBMGA002151   Pediculus humanus Human body louse  Phum\PHUM463210   Tribolium castaneum Red flour beetle  Tcas\TC003442
Orthologs in non-Insect Arthropods (EOG6GB5PK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rho   Ixodes scapularis Deer tick  Isca\ISCW011728
Orthologs in non-Arthropod Metazoa (EOG62ZHK7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cyn-12   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015088gn   Danio rerio Zebrafish  Drer\ppil1   Xenopus tropicalis Western clawed frog  Xtro\ppil1   Mus musculus House mouse  Mmus\Ppil1   Rattus norvegicus Norway rat  Rnor\Ppil1   Homo sapiens Human  Hsap\PPIL1
Human Orthologs (1)
Gene OMIM HGNC Hsap\PPIL1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25702 Drosophila sechellia Dsec\GM14273 Drosophila erecta Dere\GG14657 Drosophila yakuba Dyak\GE21017 Drosophila ananassae Dana\GF25039 Drosophila pseudoobscura pseudoobscura Dpse\GA12606 Drosophila persimilis Dper\GL22598 Drosophila willistoni Dwil\GK20536 Drosophila virilis Dvir\GJ23427 Drosophila mojavensis Dmoj\GI22699 Drosophila grimshawi Dgri\GH21768
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v104316 P{KK107406}VIE-260B v44823 w1118; P{GD8156}v44823/TM3
Genomic Clones ( 2 )
	BACR01I24 BACR18B21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04183 RE07451
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE65874 RH20884 RH27080
Other clones	5257 82724 214221.32 EK124324 EP16223
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035141 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38069
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cypl CG13892 (Nakayama, 2001.3.7)
Source for database merge of
Additional comments
Other Comments
	Cypl is required for the regulation of ovulation upon mating. (Nakayama and Aigaki, 2001) Mutants are homozygous viable and showed no obvious defects in morphology and behavior. However, mutant females mated with wild-type males showed a reduced ovulation rate and laid fewer eggs than control females. (Nakayama and Aigaki, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079150 RefSeq (Proteins) • NP_523874 DDBJ / EMBL / GenBank • AAF47391 AAL48597 AY070975 BI167131 Entrez Gene - A searchable database of RefSeq genes. • 38069 UniProtKB/TrEMBL • Q9W0Q2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cyclophilin-like peptidyl-prolyl cis-trans isomerase domain (IPR002130) Cyclophilin-type peptidyl-prolyl cis-trans isomerase (IPR024936) Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site (IPR020892) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE07451
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0035141 DRSC - Results from RNAi screens. • FBgn0035141 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035141 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG13892-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035141 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38069 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38069 modMine - Data generated by the modENCODE project. • FBgn0035141
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG13892 (Molnar et al., 2006, Keleman et al., 2009.8.5, Herold et al., 2009) cycl (Lee et al., 2009) Cypl (Butchar et al., 2012, Molnar et al., 2006, Herold et al., 2009, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Cyclophilin-like (Nakayama and Aigaki, 2001, Lee et al., 2009)
Secondary FlyBase IDs
References ( 22 )
Generate a list of	All references relating to this gene ( 22 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Butchar et al., 2012, Genetics 191(4): 1213--1226 New negative feedback regulators of egfr signaling in Drosophila. [FBrf0219175] Show all research papers ...