HIPK2
serine/threonine kinase - homolog of mammalian Homeodomain interacting protein kinase - acts as a positive regulator of Wingless pathway by stabilizing Armadillo - promotes Notch signal transduction in the eye by inhibition of the co-repressor Groucho
Please see the JBrowse view of Dmel\Hipk for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
3' UTR contains an ORF that is conserved among close Drosophila species (FBrf0202906; potential peptide 69 aa in length).
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Gene model reviewed during 5.45
Gene model reviewed during 5.46
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Gene model reviewed during 6.32
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hipk using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
During eye development, Hipk is expressed in a dynamic pattern throughout the eye disc. In late 2nd instar Hipk is enriched in the medial domain of the visual primordium including the D/V boundary of the eye disc. Starting in mid 3rd instar, Hipk expression is enriched in the anterior folds of the eye discs and becomes broadly expressed ahead of the morphogenetic furrow. Later in the 3rd instar, expression is further refined to a narrow stripe covering much of the width of the disc.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Hipk in JBrowse3-0.5
3-0.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hipk hipk
