This gene is referred to in FlyBase by the symbol Dmel\CG13900 (FBgn0035162). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: damaged DNA binding. There is experimental evidence that it is involved in the biological process: mitotic spindle organization; neurogenesis. 4 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Cleavage/polyadenylation specificity factor, A subunit, C-terminal; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633394_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG13900. Gene sequence location is 3L:826710..833402.
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modENCODE Temporal Expression Data for FBgn0035162
Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages.
[download data (TSV)]
Guide to modENCODE expression level colors
No expression (0 - 0)
Extremely low expression (1 - 10)
Very low expression (11 - 100)
Low expression (101 - 400)
Moderate expression (401 - 1400)
Moderately high expression (1401 - 4000)
High expression (4001 - 10000)
Very high expression (10001 - 100000)
Extremely high expression (100001 - 2000000)
Linear, scaled to maximum FBgn0035162 expression level
Developmental Stage
Expression Level
embryo 00-02hr
8583
embryo 02-04hr
18213
embryo 04-06hr
23004
embryo 06-08hr
17103
embryo 08-10hr
16605
embryo 10-12hr
13997
embryo 12-14hr
12081
embryo 14-16hr
10404
embryo 16-18hr
6621
embryo 18-20hr
4418
embryo 20-22hr
10071
embryo 22-24hr
8763
larva L1
14307
larva L2
7497
larva L3 12hr old
5404
larva L3 puffstage 1-2
2684
larva L3 puffstage 3-6
3712
larva L3 puffstage 7-9
4468
white prepupae new
4650
white prepupae 12hr
4330
white prepupae 24hr
5110
pupae 2d postWPP
3176
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
7846
adult female 05day
8559
adult female 30day
7928
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Very low expression
Developmental Stage
Expression Level
embryo 00-02hr
(8583)
embryo 02-04hr
(18213)
embryo 04-06hr
(23004)
embryo 06-08hr
(17103)
embryo 08-10hr
(16605)
embryo 10-12hr
(13997)
embryo 12-14hr
(12081)
embryo 14-16hr
(10404)
embryo 16-18hr
(6621)
embryo 18-20hr
(4418)
embryo 20-22hr
(10071)
embryo 22-24hr
(8763)
larva L1
(14307)
larva L2
(7497)
larva L3 12hr old
(5404)
larva L3 puffstage 1-2
(2684)
larva L3 puffstage 3-6
(3712)
larva L3 puffstage 7-9
(4468)
white prepupae new
(4650)
white prepupae 12hr
(4330)
white prepupae 24hr
(5110)
pupae 2d postWPP
(3176)
pupae 3d postWPP
(1567)
pupae 4d postWPP
(2154)
adult male 01day
(1420)
adult male 05day
(1454)
adult male 30day
(1835)
adult female 01day
(7846)
adult female 05day
(8559)
adult female 30day
(7928)
Expression Level Scale
None
Extremely low
Very low
Low
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(8583)
embryo 02-04hr
(18213)
embryo 04-06hr
(23004)
embryo 06-08hr
(17103)
embryo 08-10hr
(16605)
embryo 10-12hr
(13997)
embryo 12-14hr
(12081)
embryo 14-16hr
(10404)
embryo 16-18hr
(6621)
embryo 18-20hr
(4418)
embryo 20-22hr
(10071)
embryo 22-24hr
(8763)
larva L1
(14307)
larva L2
(7497)
larva L3 12hr old
(5404)
larva L3 puffstage 1-2
(2684)
larva L3 puffstage 3-6
(3712)
larva L3 puffstage 7-9
(4468)
white prepupae new
(4650)
white prepupae 12hr
(4330)
white prepupae 24hr
(5110)
pupae 2d postWPP
(3176)
pupae 3d postWPP
(1567)
pupae 4d postWPP
(2154)
adult male 01day
1420
adult male 05day
1454
adult male 30day
(1835)
adult female 01day
(7846)
adult female 05day
(8559)
adult female 30day
(7928)
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
8583
embryo 02-04hr
(18213)
embryo 04-06hr
(23004)
embryo 06-08hr
(17103)
embryo 08-10hr
(16605)
embryo 10-12hr
(13997)
embryo 12-14hr
(12081)
embryo 14-16hr
10404
embryo 16-18hr
6621
embryo 18-20hr
4418
embryo 20-22hr
10071
embryo 22-24hr
8763
larva L1
(14307)
larva L2
7497
larva L3 12hr old
5404
larva L3 puffstage 1-2
2684
larva L3 puffstage 3-6
3712
larva L3 puffstage 7-9
4468
white prepupae new
4650
white prepupae 12hr
4330
white prepupae 24hr
5110
pupae 2d postWPP
3176
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
7846
adult female 05day
8559
adult female 30day
7928
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
8583
embryo 02-04hr
18213
embryo 04-06hr
23004
embryo 06-08hr
17103
embryo 08-10hr
16605
embryo 10-12hr
13997
embryo 12-14hr
12081
embryo 14-16hr
10404
embryo 16-18hr
6621
embryo 18-20hr
4418
embryo 20-22hr
10071
embryo 22-24hr
8763
larva L1
14307
larva L2
7497
larva L3 12hr old
5404
larva L3 puffstage 1-2
2684
larva L3 puffstage 3-6
3712
larva L3 puffstage 7-9
4468
white prepupae new
4650
white prepupae 12hr
4330
white prepupae 24hr
5110
pupae 2d postWPP
3176
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
7846
adult female 05day
8559
adult female 30day
7928
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
log, scaled to maximum FBgn0035162 expression level
Developmental Stage
Expression Level
embryo 00-02hr
8583
embryo 02-04hr
18213
embryo 04-06hr
23004
embryo 06-08hr
17103
embryo 08-10hr
16605
embryo 10-12hr
13997
embryo 12-14hr
12081
embryo 14-16hr
10404
embryo 16-18hr
6621
embryo 18-20hr
4418
embryo 20-22hr
10071
embryo 22-24hr
8763
larva L1
14307
larva L2
7497
larva L3 12hr old
5404
larva L3 puffstage 1-2
2684
larva L3 puffstage 3-6
3712
larva L3 puffstage 7-9
4468
white prepupae new
4650
white prepupae 12hr
4330
white prepupae 24hr
5110
pupae 2d postWPP
3176
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
7846
adult female 05day
8559
adult female 30day
7928
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Very low expression
Developmental Stage
Expression Level
embryo 00-02hr
(8583)
embryo 02-04hr
(18213)
embryo 04-06hr
(23004)
embryo 06-08hr
(17103)
embryo 08-10hr
(16605)
embryo 10-12hr
(13997)
embryo 12-14hr
(12081)
embryo 14-16hr
(10404)
embryo 16-18hr
(6621)
embryo 18-20hr
(4418)
embryo 20-22hr
(10071)
embryo 22-24hr
(8763)
larva L1
(14307)
larva L2
(7497)
larva L3 12hr old
(5404)
larva L3 puffstage 1-2
(2684)
larva L3 puffstage 3-6
(3712)
larva L3 puffstage 7-9
(4468)
white prepupae new
(4650)
white prepupae 12hr
(4330)
white prepupae 24hr
(5110)
pupae 2d postWPP
(3176)
pupae 3d postWPP
(1567)
pupae 4d postWPP
(2154)
adult male 01day
(1420)
adult male 05day
(1454)
adult male 30day
(1835)
adult female 01day
(7846)
adult female 05day
(8559)
adult female 30day
(7928)
Expression Level Scale
None
Extremely low
Very low
Low
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(8583)
embryo 02-04hr
(18213)
embryo 04-06hr
(23004)
embryo 06-08hr
(17103)
embryo 08-10hr
(16605)
embryo 10-12hr
(13997)
embryo 12-14hr
(12081)
embryo 14-16hr
(10404)
embryo 16-18hr
(6621)
embryo 18-20hr
(4418)
embryo 20-22hr
(10071)
embryo 22-24hr
(8763)
larva L1
(14307)
larva L2
(7497)
larva L3 12hr old
(5404)
larva L3 puffstage 1-2
(2684)
larva L3 puffstage 3-6
(3712)
larva L3 puffstage 7-9
(4468)
white prepupae new
(4650)
white prepupae 12hr
(4330)
white prepupae 24hr
(5110)
pupae 2d postWPP
(3176)
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
(7846)
adult female 05day
(8559)
adult female 30day
(7928)
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
8583
embryo 02-04hr
18213
embryo 04-06hr
(23004)
embryo 06-08hr
17103
embryo 08-10hr
16605
embryo 10-12hr
13997
embryo 12-14hr
12081
embryo 14-16hr
10404
embryo 16-18hr
6621
embryo 18-20hr
4418
embryo 20-22hr
10071
embryo 22-24hr
8763
larva L1
14307
larva L2
7497
larva L3 12hr old
5404
larva L3 puffstage 1-2
2684
larva L3 puffstage 3-6
3712
larva L3 puffstage 7-9
4468
white prepupae new
4650
white prepupae 12hr
4330
white prepupae 24hr
5110
pupae 2d postWPP
3176
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
7846
adult female 05day
8559
adult female 30day
7928
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
8583
embryo 02-04hr
18213
embryo 04-06hr
23004
embryo 06-08hr
17103
embryo 08-10hr
16605
embryo 10-12hr
13997
embryo 12-14hr
12081
embryo 14-16hr
10404
embryo 16-18hr
6621
embryo 18-20hr
4418
embryo 20-22hr
10071
embryo 22-24hr
8763
larva L1
14307
larva L2
7497
larva L3 12hr old
5404
larva L3 puffstage 1-2
2684
larva L3 puffstage 3-6
3712
larva L3 puffstage 7-9
4468
white prepupae new
4650
white prepupae 12hr
4330
white prepupae 24hr
5110
pupae 2d postWPP
3176
pupae 3d postWPP
1567
pupae 4d postWPP
2154
adult male 01day
1420
adult male 05day
1454
adult male 30day
1835
adult female 01day
7846
adult female 05day
8559
adult female 30day
7928
Expression Level Scale
None
Extremely low
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
FlyAtlas Anatomical Expression Data for FBgn0035162
Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland, larval trachea, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass.
[download data (TSV)]
Guide to FlyAtlas expression level colors
No expression (0 - 9.999)
Low expression (10 - 99.999)
Moderate expression (100 - 499.999)
High level expression (500 - 999.999)
Very high expression (1000 - 25000)
Linear, scaled to maximum FBgn0035162 expression level
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(719.425)
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
(559.9)
Larval Trachea
(540.725)
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
(601.4)
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to maximum FBgn0035162 expression level
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
719.425
Larval Midgut
203.9
Larval Hindgut
352.1
Larval Malpighian Tubules
96.2
Larval Fat Body
101.3
Larval Salivary Gland
559.9
Larval Trachea
540.725
Larval Carcass
426.75
Adult Head
137.7
Adult Eye
83.875
Adult Brain
157.7
Adult Thoracic-Abdominal Ganglion
119.4
Adult Crop
199.1
Adult Midgut
204.2
Adult Hindgut
143.4
Adult Malpighian Tubules
219.7
Adult Fat Body
188.6
Adult Salivary Gland
272
Adult Heart
118.9
Adult VirginFemale Spermatheca
225.4
Adult InseminatedFemale Spermatheca
353.2
Adult Ovary
601.4
Adult Testis
57.5
Adult Male Accessory Gland
272.3
Adult Carcass
133.7
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 133 )
Please Note
This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see GBrowse for alignment of the cDNAs and ESTs
to the gene model.
The "l(3)0083500835" allele fails to complement alleles of the "l(3)61Db-S" and "l(3)61Dc" loci to varying extents. This suggests that the "l(3)61Db-S" and "l(3)61Dc" loci may be physically close to each other so that the single P-element insertion that causes "l(3)0083500835" (P{PZ}l(3)0083500835) may impair the function of both genes. From the position of the P{PZ}l(3)0083500835 insertion, it is likely that "l(3)61Db-S" and "l(3)61Dc" correspond to "CG13900" and "CG13886", although a one-to-one assignment cannot be established.
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.