FB2021_01, released Feb 18, 2021

Gene: Dmel\Iml1

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General Information
Symbol
Dmel\Iml1
Species
D. melanogaster
Name
Increased minichromosome loss 1
Annotation Symbol
CG12090
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035227
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
Increased minichromosome loss 1 (Iml1) encodes a component of the highly conserved GAP Activity Towards Rags 1 (GATOR1) complex, which inhibits the activity of the product of Tor in response to amino acid starvation. The product of Iml1, as well as the other GATOR1 components encoded by Nprl2 and Nprl3, regulates early meiotic progression. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
62A3-62A3
Sequence location
3L:1,523,414..1,534,034 [-]
Recombination map

3-0.5

RefSeq locus
NT_037436 REGION:1523414..1534034
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
contributes_to GTPase activator activity
inferred from biological aspect of ancestor with PANTHER:PTN000323637
(assigned by GO_Central )
(Gaudet et al., 2011)
enables GTPase activator activity
inferred from sequence or structural similarity with SGD:S000003899
(FlyBase Curators, 2008--)
Biological Process (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
involved_in germarium-derived cystoblast division
inferred from mutant phenotype
(Wei et al., 2014)
involved_in germline cell cycle switching, mitotic to meiotic cell cycle
inferred from mutant phenotype
(assigned by UniProt )
(Wei et al., 2014)
inferred from genetic interaction with UniProtKB:Q9VXA0
(assigned by UniProt )
(Wei et al., 2014)
involved_in negative regulation of cell size
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
involved_in negative regulation of TOR signaling
inferred from mutant phenotype
(assigned by UniProt )
(Bar-Peled et al., 2013)
involved_in negative regulation of TORC1 signaling
inferred from mutant phenotype
(Wei et al., 2016, Wei et al., 2014)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cellular response to amino acid starvation
inferred from biological aspect of ancestor with PANTHER:PTN000323637
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in negative regulation of TOR signaling
inferred from biological aspect of ancestor with PANTHER:PTN000323637
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in regulation of autophagy
inferred from biological aspect of ancestor with PANTHER:PTN000323637
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in lysosome
inferred from direct assay
(assigned by UniProt )
(Cai et al., 2016)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of GATOR1 complex
traceable author statement
(Cai et al., 2016)
inferred from biological aspect of ancestor with PANTHER:PTN000323637
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in lysosomal membrane
inferred from biological aspect of ancestor with PANTHER:PTN000995343
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of Seh1-associated complex
inferred from sequence or structural similarity with SGD:S000003899
(Dokudovskaya et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the IML1 family. (Q9W0E3)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
GATOR1 COMPLEX -
GATOR1 is a subcomplex of the GATOR (SEA) complex. GATOR1 possesses Rag GTPase activating protein activity and inhibits TORC1 activity in response to amino acid starvation. (Adapted from FBrf0232362 and PMID:25934700).
Protein Function (UniProtKB)
An essential component of the GATOR subcomplex GATOR1 which functions as an inhibitor of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27672113, PubMed:25512509). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:23723238, PubMed:27672113, PubMed:25512509). The function of GATOR1 in negatively regulating the TORC1 pathway is essential for maintaining baseline levels of TORC1 activity under nutrient rich conditions, and for promoting survival during amino acid or complete starvation by inhibiting TORC1-dependent cell growth and promoting catabolic metabolism and autophagy (PubMed:23723238, PubMed:27672113, PubMed:25512509). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:27672113, PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:27672113, PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:27672113, PubMed:25512509).
(UniProt, Q9W0E3)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Iml1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Iml1-RA
FBtr0072703
NM_167889
4861
1544
Iml1-RB
FBtr0072704
NM_139361
4642
1471
Iml1-RC
FBtr0072705
NM_167888
4645
1472
Iml1-RD
FBtr0333401
NM_001274330
4762
1511
Iml1-RE
FBtr0333402
NM_001274331
4738
1503
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Iml1-PA
FBpp0072587
176.7
1544
7.38
NP_728621
AAF47505
Iml1-PB
FBpp0072588
168.9
1471
7.05
NP_647618
AAN11485
Iml1-PC
FBpp0072589
168.9
1472
7.19
NP_728620
AAN11486
Iml1-PD
FBpp0305593
173.1
1511
7.04
NP_001261259
AGB93954
Iml1-PE
FBpp0305594
172.4
1503
7.42
NP_001261260
AGB93955
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823).

(UniProt, Q9W0E3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Iml1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in lysosome
inferred from direct assay
(assigned by UniProt )
(Cai et al., 2016)
part_of Seh1-associated complex
inferred from direct assay
(Cai et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Iml1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Iml1
Transgenic constructs containing regulatory region of Iml1
Aberrations (Deficiencies and Duplications) ( 3 )
Inferred from experimentation
Gene disrupted in
Df(3L)ED4238
(Wei et al., 2016)
Df(3L)Exel6087
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(3L)Iml11
(Wei et al., 2016)
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DEPDC5
13 of 15
Yes
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Depdc5
12 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Depdc5
10 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\depdc5
3 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\depdc5
13 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\T08A11.1
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\IML1
10 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC26H8.04c
8 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900GW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004499
Drosophila simulans
Dsim\GD13470
Drosophila sechellia
Dsec\GM14207
Drosophila erecta
Dere\GG14593
Drosophila yakuba
Dyak\GE20953
Drosophila ananassae
Dana\GF25030
Drosophila pseudoobscura pseudoobscura
Dpse\GA11387
Drosophila persimilis
Dper\GL22489
Drosophila willistoni
Dwil\GK17201
Drosophila virilis
Dvir\GJ12464
Drosophila mojavensis
Dmoj\GI16720
Drosophila grimshawi
Dgri\GH15201
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500AL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018878
Glossina morsitans
Tsetse fly
Gmor\GMOY005035
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07775
Mayetiola destructor
Hessian fly
Mdes\Mdes002500
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015415
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012917
Anopheles darlingi
American malaria mosquito
Adar\ADAC004643
Anopheles gambiae
Malaria mosquito
Agam\AGAP007010
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005116
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008440
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W008A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006909
Bombyx mori
Silkmoth
Bmor\Bmo.5767
Danaus plexippus
Monarch butterfly
Dple\DPOGS212999-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL004699
Apis florea
Little honeybee
Aflo\3159391652
Apis mellifera
Western honey bee
Amel\GB47808
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24869
Bombus terrestris
Buff-tailed bumblebee
Bter\15209979
Linepithema humile
Argentine ant
Lhum\LH21262
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0012e1
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004961
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07998
Tribolium castaneum
Red flour beetle
Tcas\TC012042
Pediculus humanus
Human body louse
Phum\PHUM432050
Rhodnius prolixus
Kissing bug
Rpro\RPRC006694
Cimex lectularius
Bed bug
Clec\CLEC011993
Cimex lectularius
Bed bug
Clec\CLEC011992
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007123
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004398
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI084186
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04501
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X007P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007832
Ixodes scapularis
Black-legged tick
Isca\ISCW020734
Ixodes scapularis
Black-legged tick
Isca\ISCW020735
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77251.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77249.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77253.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77248.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g15240
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_327275
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0205 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Depdc5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Disph1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Depdc5-3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Disp1-3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Depdc5-2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Depdc5-4
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024970
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000006117
Gallus gallus
Domestic chicken
Ggal\DEPDC5
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DEPDC5; DEP domain containing 5, GATOR1 subcomplex subunit
    13 of 15
    614191
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Iml1 - mio
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Cai et al., 2016)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Iml1
      enhanceable
      Nprl2
      (Wei et al., 2014)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR1 subcomplex which is likely composed of Iml1, Nplr2 and Nplr3 (PubMed:27166823).
      (UniProt, Q9W0E3 )
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map

      3-0.5

      Cytogenetic map
      62A3-62A3
      Sequence location
      3L:1,523,414..1,534,034 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      62A3-62A3
      Limits computationally determined from genome sequence between P{EP}rhoEP3704&P{PZ}l(3)0622606226 and P{PZ}dlt04276
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-0.5

      (FlyBase, 2016)

      3-2.4

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (7)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (28)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Iml1 CG12090

      (Wei et al., 2014)
      Source for database merge of
      Additional comments

      Release 4.3 annotation CG33971 corresponds to a part of release 2 annotation CG12090 which was removed from the release 3.1 version of CG12090.

      (FlyBase Genome Annotators, 2005)
      Other Comments
      Origin and Etymology
      Discoverer
      Etymology

      Named 'Iml1'/'Increased minichromosome loss 1' after the S. cerevisiae homolog.

      (Wei et al., 2014)
      Identification
      External Crossreferences and Linkouts ( 43 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (6)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (41)