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Gene Dmel\CG12024

General Information
Symbol	Dmel\CG12024	Species	D. melanogaster
Name		Annotation symbol	CG12024
Feature type	protein_coding_gene	FlyBase ID	FBgn0035283
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62B7-62B7	Sequence location	3L:1,857,165..1,859,047 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12024 (FBgn0035283). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: UBA-like; Ubiquitin system component Cue. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, larval hindgut, larval/adult Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639052_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG12024. Gene sequence location is 3L:1857165..1859047.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B7-62B7   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12024 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12024-RA FBtr0072832  NM_139413   1822   292 CG12024-RB FBtr0072833  NM_167921   1774   276 CG12024-RC FBtr0303152  NM_001202093   1777   277
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12024-PA   FBpp0072712   32.5   292   5.77     NP_647670   AAF47582 CG12024-PB   FBpp0072713   30.7   276   6.15     NP_728683   AAN11501 CG12024-PC   FBpp0292251   30.8   277   6.15     NP_001189022   ADV37459
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin system component Cue (IPR003892) UBA-like (IPR009060)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47582   AE014296 AAN11501   AE014296 ADV37459   AI061874   AI109653   AY070503 AAL47974   BI166656   BI166953   BI234346   BI570469   BI575498   BI581069   BI581070   BI607190   BI612518   BI612585   BI617847   BI620719   BI621297   BI623477   BI623529   BI624445   BI633795   BT125871   CA804903   CA806315   CA806859   CO193626   CO263352   CO264057   CO264088   CO274037   CO285798   CO287984   CO288550   CO290555   CO301628   CO314786   CO316166   CO330787   CO343769   EC060569   EC065395   EC070539   EC079003   EC079723   EC081322   EC081485   EC082157   EC198435   EC202407   EC206069   EC211374   EC232876   EC242447   EC256476   EC259617   EV584014   GH961367   GH967338   GH978834
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IRG7 Q8SZU6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, larval hindgut, larval/adult Malpighian tubules, larval fat body. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut    595.4 Larval Malpighian Tubules    741.5 Larval Fat Body    539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain    530.7 Adult Thoracic-Abdominal Ganglion    545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules    546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut  (595.4) Larval Malpighian Tubules  (741.5) Larval Fat Body  (539.3) Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain  530.7 Adult Thoracic-Abdominal Ganglion  (545) Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules  (546.4) Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut    595.4 Larval Malpighian Tubules    741.5 Larval Fat Body    539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain    530.7 Adult Thoracic-Abdominal Ganglion    545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules    546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut    595.4 Larval Malpighian Tubules    741.5 Larval Fat Body    539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain    530.7 Adult Thoracic-Abdominal Ganglion    545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules    546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut    595.4 Larval Malpighian Tubules    741.5 Larval Fat Body    539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain    530.7 Adult Thoracic-Abdominal Ganglion    545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules    546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut  595.4 Larval Malpighian Tubules  741.5 Larval Fat Body  539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain  530.7 Adult Thoracic-Abdominal Ganglion  545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules  546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut    595.4 Larval Malpighian Tubules    741.5 Larval Fat Body    539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain    530.7 Adult Thoracic-Abdominal Ganglion    545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules    546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    257.175 Larval Midgut    43.4 Larval Hindgut    595.4 Larval Malpighian Tubules    741.5 Larval Fat Body    539.3 Larval Salivary Gland    233.1 Larval Trachea    200.8 Larval Carcass    276.5 Adult Head    309.2 Adult Eye    415.8 Adult Brain    530.7 Adult Thoracic-Abdominal Ganglion    545 Adult Crop    269.7 Adult Midgut    47.1 Adult Hindgut    405.2 Adult Malpighian Tubules    546.4 Adult Fat Body    462.5 Adult Salivary Gland    169.3 Adult Heart    280 Adult VirginFemale Spermatheca    243.3 Adult InseminatedFemale Spermatheca    280.9 Adult Ovary    432.5 Adult Testis    84.9 Adult Male Accessory Gland    171.7 Adult Carcass    264.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    309.2   NA  Eye    415.8   NA  Brain    530.7   257.175  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    545   NA  Crop    269.7   43.4  Midgut    47.1   595.4  Hindgut    405.2   741.5  Malpighian Tubules    546.4   539.3  Fat Body    462.5   233.1  Salivary Gland    169.3   NA  Heart    280   200.8  Trachea    NA   NA  VirginFemale Spermatheca    243.3   NA  InseminatedFemale Spermatheca    280.9   NA  Ovary    432.5   NA  Testis    84.9   NA  Male Accessory Gland    171.7   276.5  Carcass    264.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    42 central nervous system, pupae P8    68 head, virgin 1-day female    38 head, virgin 4-day female    52 head, virgin 20-day female    41 head, mated 1-day female    36 head, mated 4-day female    36 head, mated 20-day female    34 head, mated 1-day male    55 head, mated 4-day male    60 head, mated 20-day male    65 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae    32 fat body, pupae P8    29 carcass, larvae L3 wandering    68 carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult    28 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    55 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (42) central nervous system, pupae P8  (68) head, virgin 1-day female  (38) head, virgin 4-day female  (52) head, virgin 20-day female  (41) head, mated 1-day female  (36) head, mated 4-day female  (36) head, mated 20-day female  (34) head, mated 1-day male  (55) head, mated 4-day male  (60) head, mated 20-day male  (65) salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  (27) digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae  (32) fat body, pupae P8  (29) carcass, larvae L3 wandering  (68) carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult  (28) ovary, virgin 4-day female  (100) ovary, mated 4-day female  (79) testis, mated 4-day male  (55) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    42 central nervous system, pupae P8    68 head, virgin 1-day female    38 head, virgin 4-day female    52 head, virgin 20-day female    41 head, mated 1-day female    36 head, mated 4-day female    36 head, mated 20-day female    34 head, mated 1-day male    55 head, mated 4-day male    60 head, mated 20-day male    65 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae    32 fat body, pupae P8    29 carcass, larvae L3 wandering    68 carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult    28 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    55 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    42 central nervous system, pupae P8    68 head, virgin 1-day female    38 head, virgin 4-day female    52 head, virgin 20-day female    41 head, mated 1-day female    36 head, mated 4-day female    36 head, mated 20-day female    34 head, mated 1-day male    55 head, mated 4-day male    60 head, mated 20-day male    65 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae    32 fat body, pupae P8    29 carcass, larvae L3 wandering    68 carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult    28 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    55 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    42 central nervous system, pupae P8    68 head, virgin 1-day female    38 head, virgin 4-day female    52 head, virgin 20-day female    41 head, mated 1-day female    36 head, mated 4-day female    36 head, mated 20-day female    34 head, mated 1-day male    55 head, mated 4-day male    60 head, mated 20-day male    65 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae    32 fat body, pupae P8    29 carcass, larvae L3 wandering    68 carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult    28 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    55 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (45) central nervous system, larvae L3  (42) central nervous system, pupae P8  (68) head, virgin 1-day female  (38) head, virgin 4-day female  (52) head, virgin 20-day female  (41) head, mated 1-day female  (36) head, mated 4-day female  (36) head, mated 20-day female  (34) head, mated 1-day male  (55) head, mated 4-day male  (60) head, mated 20-day male  (65) salivary gland, larvae L3 wandering    19 salivary gland, white prepupae  27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae  32 fat body, pupae P8  29 carcass, larvae L3 wandering  (68) carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult  28 ovary, virgin 4-day female  (100) ovary, mated 4-day female  (79) testis, mated 4-day male  (55) accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    42 central nervous system, pupae P8    68 head, virgin 1-day female    38 head, virgin 4-day female    52 head, virgin 20-day female    41 head, mated 1-day female    36 head, mated 4-day female    36 head, mated 20-day female    34 head, mated 1-day male    55 head, mated 4-day male    60 head, mated 20-day male    65 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae    32 fat body, pupae P8    29 carcass, larvae L3 wandering    68 carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult    28 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    55 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    45 central nervous system, larvae L3    42 central nervous system, pupae P8    68 head, virgin 1-day female    38 head, virgin 4-day female    52 head, virgin 20-day female    41 head, mated 1-day female    36 head, mated 4-day female    36 head, mated 20-day female    34 head, mated 1-day male    55 head, mated 4-day male    60 head, mated 20-day male    65 salivary gland, larvae L3 wandering    19 salivary gland, white prepupae    27 digestive system, larvae L3 wandering    15 digestive system, 1-day adult    18 digestive system, 4-day adult    15 digestive system, 20-day adult    15 fat body, larvae L3 wandering    14 fat body, white prepupae    32 fat body, pupae P8    29 carcass, larvae L3 wandering    68 carcass, 1-day adult    21 carcass, 4-day adult    24 carcass, 20-day adult    28 ovary, virgin 4-day female    100 ovary, mated 4-day female    79 testis, mated 4-day male    55 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    43 white prepupae new    42 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day    33 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (43) white prepupae new  (42) white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day  (33) adult female 30day  (32) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    43 white prepupae new    42 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day    33 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    43 white prepupae new    42 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day    33 adult female 30day    32 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    43 white prepupae new    42 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day    33 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (47) embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9  (43) white prepupae new  (42) white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day  (33) adult female 30day  32 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    43 white prepupae new    42 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day    33 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    47 embryo 02-04hr    6 embryo 04-06hr    6 embryo 06-08hr    13 embryo 08-10hr    16 embryo 10-12hr    20 embryo 12-14hr    18 embryo 14-16hr    13 embryo 16-18hr    14 embryo 18-20hr    14 embryo 20-22hr    11 embryo 22-24hr    12 larva L1    12 larva L2    9 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    21 larva L3 puffstage 7-9    43 white prepupae new    42 white prepupae 12hr    20 white prepupae 24hr    23 pupae 2d postWPP    24 pupae 3d postWPP    20 pupae 4d postWPP    12 adult male 01day    17 adult male 05day    20 adult male 30day    18 adult female 01day    18 adult female 05day    33 adult female 30day    32 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167    75 embryonic S1    24 embryonic S3    42 leg disc CME L1    30 wing disc CME-W2    9 wing disc ML-DmD8    39 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    46 ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (90) Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167  (75) embryonic S1    24 embryonic S3  (42) leg disc CME L1  (30) wing disc CME-W2    9 wing disc ML-DmD8  (39) wing disc ML-DmD9  (34) wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32  (29) haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11  (30) antennal disc ML-DmD20-c5  (55) mixed discs ML-DmD4-c1  (47) CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2  (31) tumorous blood cells mbn2  (46) ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167    75 embryonic S1    24 embryonic S3    42 leg disc CME L1    30 wing disc CME-W2    9 wing disc ML-DmD8    39 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    46 ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167    75 embryonic S1    24 embryonic S3    42 leg disc CME L1    30 wing disc CME-W2    9 wing disc ML-DmD8    39 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    46 ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167    75 embryonic S1    24 embryonic S3    42 leg disc CME L1    30 wing disc CME-W2    9 wing disc ML-DmD8    39 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    46 ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (90) Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167  (75) embryonic S1    24 embryonic S3  (42) leg disc CME L1  30 wing disc CME-W2    9 wing disc ML-DmD8  (39) wing disc ML-DmD9  (34) wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32  29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11  30 antennal disc ML-DmD20-c5  (55) mixed discs ML-DmD4-c1  (47) CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2  31 tumorous blood cells mbn2  (46) ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167    75 embryonic S1    24 embryonic S3    42 leg disc CME L1    30 wing disc CME-W2    9 wing disc ML-DmD8    39 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    46 ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    90 Schneider line 2 Sg4    24 embryonic 1182-4H    19 embryonic GM2    25 embryonic Kc167    75 embryonic S1    24 embryonic S3    42 leg disc CME L1    30 wing disc CME-W2    9 wing disc ML-DmD8    39 wing disc ML-DmD9    34 wing disc ML-DmD16-c3    24 wing disc ML-DmD21    18 wing disc ML-DmD32    29 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    30 antennal disc ML-DmD20-c5    55 mixed discs ML-DmD4-c1    47 CNS ML-DmBG1-c1    15 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    46 ovary fGS/OSS    13 ovary OSC    13 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    62 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    51 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (43) Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (62) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (51) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3  (43) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (61) Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult  (52) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    62 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    51 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    62 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    51 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    62 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    51 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (43) Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult  (62) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult  (51) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3  (43) Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (61) Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult  (52) Paraquat 10 mM 48 hrs, 4-day adult  (41) Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    62 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    51 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    20 cold shock, 4-day adult    19 heat shock, 4-day adult    24 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    43 Cadmium 50 mM 48 hrs, 4-day adult    25 Cadmium 100 mM 48 hrs, 4-day adult    62 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    51 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    15 Ethanol 10% 3 hrs, larvae L3    13 Caffeine 1.5 mg/ml 4 hrs, larvae L3    19 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    61 Caffeine 25 mg/ml 48 hrs, 4-day adult    25 Paraquat 5 mM 48 hrs, 4-day adult    52 Paraquat 10 mM 48 hrs, 4-day adult    41 Rotenone 2 μg 12 hrs, larvae L3    15 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • PC00188 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12024-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG12024GD7463 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG12024 Class Mutagen Stocks Known lesion CG12024GT-000196 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12024 Class Mutagen Stocks Known lesion CG12024GD7463 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG12024NIG.12024R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6088 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD7463} NA P{NIG.12024R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}CG12024GT-000196 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG12024 - CG3529 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12024 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0035283 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38243
Orthologs
OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62RDTN Dipteran inclusive ortholog search EOG6N30Z2 Insect inclusive ortholog search EOG6B8H99 Arthropod inclusive ortholog search EOG6FTTGQ Metazoa inclusive ortholog search EOG6BGNQJ
Orthologs in Drosophila Species (EOG62RDTN)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG12024     Drosophila simulans   Dsim\GD13653 Y   Drosophila sechellia   Dsec\GM14453 Y   Drosophila erecta   Dere\GG14831 Y   Drosophila yakuba   Dyak\GE21194 Y   Drosophila ananassae   Dana\GF24842 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11346 Y   Drosophila persimilis   Dper\GL25312 Y   Drosophila willistoni   Dwil\GK20332 Y   Drosophila virilis   Dvir\GJ12428 Y   Drosophila mojavensis   Dmoj\GI16694 Y   Drosophila mojavensis   Dmoj\GI11270     Drosophila grimshawi   Dgri\GH16439 Y
Orthologs in non-Drosophila Dipterans (EOG6N30Z2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013384   Anopheles gambiae Malaria mosquito  Agam\AGAP006084   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011493
Orthologs in non-Dipteran Insects (EOG6B8H99)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\shu   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037032   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019763   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15262   Atta cephalotes Leafcutter ant  Acep\ACEP16624   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17402   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23205   Linepithema humile Argentine ant  Lhum\LH22945   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15357   Solenopsis invicta Red fire ant  Sinv\SINV22584   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009379   Bombyx mori Silkmoth  Bmor\BGIBMGA005481   Pediculus humanus Human body louse  Phum\PHUM233620
Orthologs in non-Insect Arthropods (EOG6FTTGQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW001485
Orthologs in non-Arthropod Metazoa (EOG6BGNQJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F43C1.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024329gn   Danio rerio Zebrafish  Drer\ENSDARG00000054748   Danio rerio Zebrafish  Drer\ENSDARG00000068716   Xenopus tropicalis Western clawed frog  Xtro\cuedc1   Gallus gallus Domestic chicken  Ggal\CUEDC1   Mus musculus House mouse  Mmus\Cuedc1   Rattus norvegicus Norway rat  Rnor\Cuedc1   Homo sapiens Human  Hsap\CUEDC1
Human Orthologs (1)
Gene OMIM HGNC Hsap\CUEDC1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13653 Drosophila sechellia Dsec\GM14453 Drosophila erecta Dere\GG14831 Drosophila yakuba Dyak\GE21194 Drosophila ananassae Dana\GF24842 Drosophila pseudoobscura pseudoobscura Dpse\GA11346 Drosophila persimilis Dper\GL25312 Drosophila willistoni Dwil\GK20332 Drosophila virilis Dvir\GJ12428 Drosophila mojavensis Dmoj\GI16694 Drosophila grimshawi Dgri\GH16439
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	20977 w1118; P{GT1}CG12024GT-000196
VDRC	v20143 w1118; P{GD7463}v20143/TM3
Genomic Clones ( 1 )
	BACR10D15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 55 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08896 RE72350
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03008 RE06851 RE07210 RE30045 RH02811 RH31179 RH41410 RH41512 RH48305 RH51920 RH52617 RH55745 RH55821 RH64007 RH74203 SD27955
Other clones	12192 29343 29494 54998 103776 108999 193282 214317.26 214499.27 CK01.20A.F2 CK01.77D.A12 CK01.84B.D6 CK01.100C.H8 CK01.105C.D9 CK01.117B.D3 Dmel_dig_019425_0659_1136 EC36511 EK060734 EK067454 EK068847 EK074307 EK088313 EK112940 EK137262 EK137348 EK181740 EK237803 EK263830 EK296162 EP18012 ESG012d.E21_B03 ESG015b.E21_E06 ESG0115c.B21_H02 RH01078 RP004257227 RP004468792 RP004535173
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38243
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139413 NM_167921 NM_001202093 RefSeq (Proteins) • NP_647670 NP_728683 NP_001189022 DDBJ / EMBL / GenBank • AAF47582 AAL47974 AAN11501 ADV37459 AI109653 AY070503 Entrez Gene - A searchable database of RefSeq genes. • 38243 UniProtKB/TrEMBL • Q8IRG7 Q8SZU6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin system component Cue (IPR003892) UBA-like (IPR009060) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00188
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0035283 DRSC - Results from RNAi screens. • FBgn0035283 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035283 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12024-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035283 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38243 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38243 modMine - Data generated by the modENCODE project. • FBgn0035283
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12024 (Eulalio et al., 2009, Bushati et al., 2008, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Eulalio et al., 2009, RNA 15(1): 21--32 Deadenylation is a widespread effect of miRNA regulation. [FBrf0215694] Bushati et al., 2008, Curr. Biol. 18(7): 501--506 Temporal reciprocity of miRNAs and their targets during the maternal-to-zygotic transition in Drosophila. [FBrf0204359]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.9.23, RS lines for Bloomington. RS lines for Bloomington. [FBrf0179866] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]
Website	Fisher et al., 2012, BDGP insitu homepage BDGP insitu homepage [FBrf0219073]
Curated genome annotation	Heiman, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126693]