FlyBase Gene Report: Dmel\MsR1

General Information

Symbol

Dmel\MsR1

Species

D. melanogaster

Name

Myosuppressin receptor 1

Annotation Symbol

CG8985

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035331

Gene Model Status

Current

Stock Availability

57 publicly available

Gene Summary

Myosuppressin receptor 1 (MsR1) encodes a class A transmembrane G protein coupled receptor that binds the neuropeptide ligand encoded by Ms and acts through the adenylate cyclase-inhibiting GPCR signaling pathway. It inhibits visceral muscle contraction, and negatively regulates cardiac contractility and gut motility. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DmsR-1, Dromyosuppressin receptor 1

Key Links

Genomic Location

Cytogenetic map

62D6-62D6

Sequence location

3L:2,322,693..2,345,799 [+]

Recombination map

3-2

RefSeq locus

NT_037436 REGION:2322693..2345799

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables myosuppressin receptor activity

inferred from physical interaction with FLYBASE:Ms; FB:FBgn0011581

(Egerod et al., 2003)

inferred from direct assay

(Johnson et al., 2003)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN002922214

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR019427

(InterPro Project Members, 2004-)

enables G protein-coupled receptor activity

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

enables neuropeptide receptor activity

inferred from sequence model

(Hewes and Taghert, 2001)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

inferred from direct assay

(Johnson et al., 2003)

involved_in adult locomotory behavior

inferred from mutant phenotype

(Kiss et al., 2013)

involved_in neuropeptide signaling pathway

inferred from direct assay

(Egerod et al., 2003, Johnson et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in G protein-coupled receptor signaling pathway

inferred from sequence model

(Hewes and Taghert, 2001)

inferred from electronic annotation with InterPro:IPR000276

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002922214

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Johnson et al., 2003)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence or structural similarity

(Brody and Cravchik, 2000)

inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452

(InterPro Project Members, 2004-)

inferred from sequence model

(Hewes and Taghert, 2001)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002922214

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

CLASS A GPCR NEUROPEPTIDE AND PROTEIN HORMONE RECEPTORS -: The majority of neuropeptide/protein hormone GPCR belong to the Class A family of GPCRs. The secreted ligands for this subfamily include neuropeptides, peptide hormones and protein hormones. (Adapted from FBrf0195077).

Summary (Interactive Fly)

Myosuppressin receptors are crop muscle receptors through which Ms signals to modulate crop enlargement - MsRs exhibit a unique ionic lock, a novel 3-6 lock, a transmission switch, and a tyrosine toggle switch involved in mechanisms underlying TM movement and MS-R activation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\MsR1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9PEC0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Gene model reviewed during 5.45

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

MsR1-RA

FBtr0072887

NM_139456

3544

478

MsR1-RB

FBtr0330187

NM_001274395

3544

556

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

MsR1-PA

FBpp0072765

53.2

478

9.57

FBpp0303220

61.4

556

9.99

M9PEC0

NP_001261324

AGB94019

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\MsR1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

MsR1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.93

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

VUM4 interneuron

(Fontana and Crews, 2012)

VUM6 interneuron

(Fontana and Crews, 2012)

RNA-seq

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

ventral midline of embryo

(Fontana and Crews, 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

crop

(Veenstra et al., 2008)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Johnson et al., 2003)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\MsR1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\MsR1

View exonic expression by tissue for Dmel\MsR1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38298/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035331

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035331

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035331

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8985

Flygut - An atlas of the Drosophila adult midgut

FBgn0035331

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of MsR1

Transgenic constructs containing regulatory region of MsR1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^Act5C.PU

MsR1^KK109948

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

MsR1^GD636

viable, with Scer\GAL4^Act5C.PU

MsR1^GD636

viable, with Scer\GAL4^Mef2.PR

MsR1^GD636

viable, with Scer\GAL4^pnr-MD237

MsR1^GD636

viable, with Scer\GAL4^tin.CΔ4

MsR1^GD636

Other Phenotypes

Allele

abnormal locomotor behavior, with Scer\GAL4^Act5C.PU

MsR1^KK109948

visible, with Scer\GAL4^Act5C.PU

MsR1^KK109948

Phenotype manifest in

Allele

wing, with Scer\GAL4^Act5C.PU

MsR1^KK109948

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (30)

Hsap\GPR139

4 of 14

Yes

Hsap\GPR142

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FPR2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\P2RY12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Gpr139

4 of 14

Yes

Rnor\Gpr142

3 of 14

Yes

Rnor\Adra1a

1 of 14

Rnor\Cckar

1 of 14

Rnor\Fpr1

1 of 14

Yes

Rnor\Fpr-rs4

1 of 14

Yes

Rnor\Gpr182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (20)

Mmus\Gpr139

3 of 14

Yes

Mmus\Gpr142

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Fpr2

1 of 14

Yes

Mmus\Fpr-rs3

1 of 14

Yes

Mmus\Fpr-rs4

1 of 14

Yes

Mmus\Gpr50

1 of 14

Mmus\Gpr182

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (20)

Xtro\gpr139

3 of 13

Yes

Xtro\gpr142

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\sstr2

1 of 13

Xtro\trhr2

1 of 13

Xtro\trhr

1 of 13

Danio rerio (Zebrafish) (37)

Drer\gpr139

5 of 14

Yes

Drer\gpr142

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (184)

Cele\dmsr-1

11 of 14

Yes

Cele\dmsr-4

10 of 14

Yes

Cele\dmsr-7

10 of 14

Yes

Cele\dmsr-8

10 of 14

Yes

Cele\dmsr-6

9 of 14

Yes

Cele\dmsr-5

8 of 14

Yes

Cele\dmsr-2

5 of 14

Yes

Cele\dmsr-3

4 of 14

Yes

Cele\dmsr-14

4 of 14

Yes

Cele\dmsr-9

3 of 14

Yes

Cele\dmsr-11

3 of 14

Yes

Cele\dmsr-13

3 of 14

Yes

Cele\dmsr-16

3 of 14

Yes

Cele\egl-6

3 of 14

Yes

Cele\B0334.6

2 of 14

Yes

Cele\dmsr-10

2 of 14

Yes

Cele\dmsr-12

2 of 14

Yes

Cele\dmsr-15

2 of 14

Yes

Cele\frpr-7

2 of 14

Yes

Cele\M03F8.7

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\D1014.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\K03H6.5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\R13H7.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\srw-2

1 of 14

Yes

Cele\srw-3

1 of 14

Yes

Cele\srw-4

1 of 14

Yes

Cele\srw-6

1 of 14

Yes

Cele\srw-7

1 of 14

Yes

Cele\srw-8

1 of 14

Yes

Cele\srw-9

1 of 14

Yes

Cele\srw-10

1 of 14

Yes

Cele\srw-11

1 of 14

Yes

Cele\srw-12

1 of 14

Yes

Cele\srw-13

1 of 14

Yes

Cele\srw-14

1 of 14

Yes

Cele\srw-15

1 of 14

Yes

Cele\srw-16

1 of 14

Yes

Cele\srw-17

1 of 14

Yes

Cele\srw-19

1 of 14

Yes

Cele\srw-20

1 of 14

Yes

Cele\srw-21

1 of 14

Yes

Cele\srw-22

1 of 14

Yes

Cele\srw-23

1 of 14

Yes

Cele\srw-24

1 of 14

Yes

Cele\srw-26

1 of 14

Yes

Cele\srw-29

1 of 14

Yes

Cele\srw-31

1 of 14

Yes

Cele\srw-32

1 of 14

Yes

Cele\srw-33

1 of 14

Yes

Cele\srw-34

1 of 14

Yes

Cele\srw-35

1 of 14

Yes

Cele\srw-36

1 of 14

Yes

Cele\srw-38

1 of 14

Yes

Cele\srw-39

1 of 14

Yes

Cele\srw-40

1 of 14

Yes

Cele\srw-41

1 of 14

Yes

Cele\srw-42

1 of 14

Yes

Cele\srw-43

1 of 14

Yes

Cele\srw-44

1 of 14

Yes

Cele\srw-48

1 of 14

Yes

Cele\srw-51

1 of 14

Yes

Cele\srw-53

1 of 14

Yes

Cele\srw-54

1 of 14

Yes

Cele\srw-55

1 of 14

Yes

Cele\srw-56

1 of 14

Yes

Cele\srw-57

1 of 14

Yes

Cele\srw-59

1 of 14

Yes

Cele\srw-60

1 of 14

Yes

Cele\srw-61

1 of 14

Yes

Cele\srw-62

1 of 14

Yes

Cele\srw-63

1 of 14

Yes

Cele\srw-66

1 of 14

Yes

Cele\srw-67

1 of 14

Yes

Cele\srw-68

1 of 14

Yes

Cele\srw-69

1 of 14

Yes

Cele\srw-71

1 of 14

Yes

Cele\srw-72

1 of 14

Yes

Cele\srw-73

1 of 14

Yes

Cele\srw-76

1 of 14

Yes

Cele\srw-77

1 of 14

Yes

Cele\srw-79

1 of 14

Yes

Cele\srw-82

1 of 14

Yes

Cele\srw-83

1 of 14

Yes

Cele\srw-84

1 of 14

Yes

Cele\srw-87

1 of 14

Yes

Cele\srw-88

1 of 14

Yes

Cele\srw-89

1 of 14

Yes

Cele\srw-90

1 of 14

Yes

Cele\srw-91

1 of 14

Yes

Cele\srw-94

1 of 14

Yes

Cele\srw-95

1 of 14

Yes

Cele\srw-97

1 of 14

Yes

Cele\srw-98

1 of 14

Yes

Cele\srw-99

1 of 14

Yes

Cele\srw-100

1 of 14

Yes

Cele\srw-101

1 of 14

Yes

Cele\srw-102

1 of 14

Yes

Cele\srw-103

1 of 14

Yes

Cele\srw-107

1 of 14

Yes

Cele\srw-109

1 of 14

Yes

Cele\srw-111

1 of 14

Yes

Cele\srw-112

1 of 14

Yes

Cele\srw-113

1 of 14

Yes

Cele\srw-115

1 of 14

Yes

Cele\srw-117

1 of 14

Yes

Cele\srw-118

1 of 14

Yes

Cele\srw-119

1 of 14

Yes

Cele\srw-120

1 of 14

Yes

Cele\srw-121

1 of 14

Yes

Cele\srw-122

1 of 14

Yes

Cele\srw-123

1 of 14

Yes

Cele\srw-124

1 of 14

Yes

Cele\srw-127

1 of 14

Yes

Cele\srw-129

1 of 14

Yes

Cele\srw-130

1 of 14

Yes

Cele\srw-133

1 of 14

Yes

Cele\srw-134

1 of 14

Yes

Cele\srw-136

1 of 14

Yes

Cele\srw-137

1 of 14

Yes

Cele\srw-138

1 of 14

Yes

Cele\srw-139

1 of 14

Yes

Cele\srw-140

1 of 14

Yes

Cele\srw-141

1 of 14

Yes

Cele\srw-142

1 of 14

Yes

Cele\srw-143

1 of 14

Yes

Cele\srw-144

1 of 14

Yes

Cele\srw-145

1 of 14

Yes

Cele\T11F9.1

1 of 14

Yes

Cele\T26H8.4

1 of 14

Yes

Cele\T26H8.5

1 of 14

Yes

Cele\T27C5.10

1 of 14

Yes

Cele\trhr-1

1 of 14

Cele\Y70D2A.1

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP005229

11 of 12

Yes

7 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:MsR1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

12 of 13

7 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

SPR

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Lkr

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GPR139; G protein-coupled receptor 139

4 of 14

618448

GPR142; G protein-coupled receptor 142

3 of 14

609046

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

MsR1 - HIP-R

experimental knowledge based

(Guruharsha et al., 2011)

MsR1 - Ms

phenotype-based detection assay, fluorescence microscopy, inferred by author

(Johnson et al., 2003)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0035331

MIST (protein-protein) - An integrated Molecular Interaction Database

38298

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-2

Cytogenetic map

62D6-62D6

Sequence location

3L:2,322,693..2,345,799 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62D6-62D6

Limits computationally determined from genome sequence between P{PZ}sls^rL182 and P{PZ}Spn⁰⁶⁹¹¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-2

(FlyBase, 2016)

3-4.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (57)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

84524

w^*; TI{TI}MsR1^attP

39262

w¹¹¹⁸; P{GMR60H02-GAL4}attP2

39310

w¹¹¹⁸; P{GMR64F06-GAL4}attP2

39312

w¹¹¹⁸; P{GMR64F08-GAL4}attP2

39353

w¹¹¹⁸; P{GMR65D07-GAL4}attP2

39355

w¹¹¹⁸; P{GMR65E01-GAL4}attP2

Korea

15953

P{GMR64F06-lexA}JK22C

16275

P{GMR65E01-lexA}attP2

17588

P{GMR66B08-lexA}attP40

v101845

v9369

v9370

More stocks available...

Genomic Clones (34)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

HL01032

Other clones

FI12701

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035331

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035331

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: DmsR-1 anon-WO0170980.106 anon-WO0170980.107

(FlyBase, 1996-)

Additional comments

Source for merge of DmsR-1 anon-WO0170980.106 anon-WO0170980.107 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: DmsR-1 CG8985

(Egerod et al., 2003)

Source for identity of: MsR1 DmsR-1

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'DmsR-1/Dromyosuppressin receptor 1' to 'MsR1/Myosuppressin receptor 1' to remove the unnecessary reference to 'Drosophila' and comply with FlyBase nomenclature rules.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

CG8985

(Mao et al., 2024, Liu et al., 2021, Jayakumar et al., 2016, Yu et al., 2016, Kiss et al., 2013, Nässel and Winther, 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Chintapalli et al., 2007, Hauser et al., 2006, Hauser et al., 2006, Metpally and Sowdhamini, 2005, Egerod et al., 2003, Johnson et al., 2003, Hewes and Taghert, 2001, Hewes and Taghert, 2001.7.31, Brody and Cravchik, 2000)

DMS R1

(Qi et al., 2021)

DMS-R1

(Bass et al., 2014)

DMSR-1

(Egerod et al., 2003)

Dm CG8985

(Yapici et al., 2008)

DmsR

(Bellen et al., 2011)

DmsR-1

(Adebambo et al., 2020, Aradska et al., 2015, Milakovic et al., 2014, Kiss et al., 2013, Caers et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Klose et al., 2010)

MS-R

(Rasmussen et al., 2015)

Ms-R1

(Taghert, 2022)

MsR1

(Akagi et al., 2025, Janssens et al., 2025, Corthals et al., 2023, Schlichting et al., 2022, Kannangara et al., 2021, McLaughlin et al., 2021, Hadjieconomou et al., 2020, Meltzer et al., 2019, Rao and Deng, 2019.10.23)

Myo R1

(Ormerod et al., 2022)

anon-WO0170980.106

anon-WO0170980.107

Name Synonyms

DMS-receptor1

(Veenstra et al., 2008)

Dromyosuppressin receptor 1

(Ormerod et al., 2022, Egerod et al., 2003)

Myosuppressin receptor 1

(Yu et al., 2016, Caers et al., 2012)

Secondary FlyBase IDs

FBgn0046618
FBgn0046619

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38298

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9PEC0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9PEC0

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38298/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035331

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035331

FlyMine - An integrated database for Drosophila genomics

FBgn0035331

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8985

MARRVEL_MODEL - MARRVEL (model organism gene)

38298

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035331

DroID - A comprehensive database of gene and protein interactions.

FBgn0035331

DRSC - Results frm RNAi screens

FBgn0035331

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

MsR1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035331

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035331

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8985

Flygut - An atlas of the Drosophila adult midgut

FBgn0035331

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

38298

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

-0.93

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