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Gene Dmel\MEP-1

General Information
Symbol	Dmel\MEP-1	Species	D. melanogaster
Name		Annotation symbol	CG1244
Feature type	protein_coding_gene	FlyBase ID	FBgn0035357
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	MEP1
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62E8-62E8	Sequence location	3L:2,631,715..2,641,984 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\MEP-1 (CG1244, FBgn0035357). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; nucleosome-dependent ATPase activity; chromatin binding. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter. 9 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval hindgut, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1638162_s_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of MEP-1 expression signal. See the GBrowse view of MEP-1 to determine the overlapping gene(s). Gene sequence location is 3L:2631715..2641984.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62E8-62E8   Limits computationally determined from genome sequence between P{PZ}Spn06911 and P{PZ}l(3)0680306803
Experimentally Determined Cytological Location
Cytogenetic map Notes References 62F1-62F2   (determined by in situ hybridisation)   (Lukacsovich et al., 2001)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\MEP-1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	gene_with_dicistronic_mRNA ; SO:0000722 Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) MEP-1-RA FBtr0072932  NM_139476   4966   1152 MEP-1-RB FBtr0072933  NM_167958   4956   1152 MEP-1-RC FBtr0072931  NM_167959   5111   1152 MEP-1-RD FBtr0072934  NM_167960   4732   1152 MEP-1-RE FBtr0072936  NM_167961   4555   1152 MEP-1-RF FBtr0072935  NM_167962   4545   1152 MEP-1-RG FBtr0290340  NM_001144403   5171   1152
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein MEP-1-PA   FBpp0072809   124.1   1152   4.65     NP_647733   AAG22230 MEP-1-PB   FBpp0072810   124.1   1152   4.65     NP_728761   AAF47669 MEP-1-PC   FBpp0072808   124.1   1152   4.65     NP_728762   AAF47670 MEP-1-PD   FBpp0072811   124.1   1152   4.65     NP_728763   AAG22231 MEP-1-PE   FBpp0072813   124.1   1152   4.65     NP_728764   AAN11519 MEP-1-PF   FBpp0072812   124.1   1152   4.65     NP_728765   AAN11520 MEP-1-PG   FBpp0288779   124.1   1152   4.65     NP_001137875   ACL83231
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140962   AA201343   AA201638   AA201796   AA201821   AA203024   AA246731   AA263362   AA263716   AA264264   AA390856   AA391129   AA391579   AA392630   AA392788   AA438443   AA438656   AA438761   AA439235   AA439505   AA439520   AA439677   AA440112   AA441604   AA441660   AA538845   AA538878   AA540852   AA567494   AA735470   AA802285   AA817226   AA817546   AA820555   AA940686   AA940687   AA940791   AA941171   AA941806   AA949936   AA949937   AA951900   AE014296 AAF47669   AE014296 AAF47670   AE014296 AAG22230   AE014296 AAG22231   AE014296 AAN11519   AE014296 AAN11520   AE014296 ACL83231   AI062490   AI064394   AI124269   AI134322   AI260708   AI455252   AI511966   AI513061   AI514516   AI514863   AI515598   AI516278   AI518689   AI520254   AI532827   AI532909   AI533393   AI534387   AI534467   AI542976   AI543788   AI544236   AW942638   AX094460   AY069499 AAL39644   BF501466   BG632199   BG637780   BG639004   BG639097   BI164401   BI216426   BI238072   BI240943   BI351785   BI353233   BI353522   BI364261   BI364272   BI365845   BI365855   BI369205   BI369817   BI369832   BI372846   BI375546   BI484347   BI635950   BI641855   BP540968   BP541483   BP549630   BP558579   BT023882   CK131694   CK605170   CK660766   CO189182   CO262921   CO263436   CO276678   CO279304   CO282532   CO283816   CO284347   CO287788   CO298443   CO300124   CO306205   CO306992   CO311274   CO314142   CO318143   CO320141   CO320297   CO325696   CO333082   CZ487945   EC060177   EC062098   EC063632   EC076731   EC079339   EC080753   EC082053   EC085610   EC090031   EC198294   EC201003   EC205247   EC205745   EC208281   EC209481   EC212582   EC219672   EC226369   EC227549   EC227582   EC230518   EC236706   EC237920   EC238005   EC245171   EC249646   EV580293   EV591511   EV592104   EV593719   EV595222   GH739760   GH739989   GH740428   GH740932   GH741052   GH741306   GH741421   GH741983   GH742076   GH742685   GH742803   GH742983   GH743071   GH743261   GH743279   GH743560   GH743636   GH744822   GH744910   GH745182   GH745687   GH746626   GH746760   GH761744   GH761837   GH762193   GH762460   GH762674   GH763056   GH763146   GH763789   GH763993   GH764401   GH764573   GH764792   GH765209   GH765742   GH765853   GH766033   GH766155   GH766389   GH766484   GH766506   GH766605   GH767656   GH767784   GH768277   GH768638   GH768974   GH769486   GH769580   GO254454
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q0E8J0 Q8T078
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Kunert et al., 2009) NuRD complex inferred from physical interaction with Mi-2 (Reddy et al., 2010) polytene chromosome inferred from direct assay (Reddy et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval hindgut, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    433.85 Larval Midgut    78.3 Larval Hindgut    117.9 Larval Malpighian Tubules    91.7 Larval Fat Body    66.5 Larval Salivary Gland    210.8 Larval Trachea    166.525 Larval Carcass    126.625 Adult Head    115.5 Adult Eye    118.425 Adult Brain    296.2 Adult Thoracic-Abdominal Ganglion    217 Adult Crop    104.5 Adult Midgut    73.1 Adult Hindgut    93.3 Adult Malpighian Tubules    114.2 Adult Fat Body    83.1 Adult Salivary Gland    118.6 Adult Heart    75.525 Adult VirginFemale Spermatheca    60.1 Adult InseminatedFemale Spermatheca    62.1 Adult Ovary    318.3 Adult Testis    30.4 Adult Male Accessory Gland    142.2 Adult Carcass    64.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    115.5   NA  Eye    118.425   NA  Brain    296.2   433.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    217   NA  Crop    104.5   78.3  Midgut    73.1   117.9  Hindgut    93.3   91.7  Malpighian Tubules    114.2   66.5  Fat Body    83.1   210.8  Salivary Gland    118.6   NA  Heart    75.525   166.525  Trachea    NA   NA  VirginFemale Spermatheca    60.1   NA  InseminatedFemale Spermatheca    62.1   NA  Ovary    318.3   NA  Testis    30.4   NA  Male Accessory Gland    142.2   126.625  Carcass    64.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    92 central nervous system, pupae P8    51 head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    16 head, mated 1-day male    32 head, mated 4-day male    35 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering    45 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    105 testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (50) central nervous system, larvae L3  (92) central nervous system, pupae P8  (51) head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female  (27) head, mated 20-day female    16 head, mated 1-day male  (32) head, mated 4-day male  (35) head, mated 20-day male  (33) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering  (45) carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female  (94) ovary, mated 4-day female  (105) testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    92 central nervous system, pupae P8    51 head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    16 head, mated 1-day male    32 head, mated 4-day male    35 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering    45 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female  105 testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    92 central nervous system, pupae P8    51 head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    16 head, mated 1-day male    32 head, mated 4-day male    35 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering    45 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    105 testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    92 central nervous system, pupae P8    51 head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    16 head, mated 1-day male    32 head, mated 4-day male    35 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering    45 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    105 testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (50) central nervous system, larvae L3  (92) central nervous system, pupae P8  (51) head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female  27 head, mated 20-day female    16 head, mated 1-day male  32 head, mated 4-day male  (35) head, mated 20-day male  (33) salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering  (45) carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female  (94) ovary, mated 4-day female  (105) testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    92 central nervous system, pupae P8    51 head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    16 head, mated 1-day male    32 head, mated 4-day male    35 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering    45 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female  105 testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    50 central nervous system, larvae L3    92 central nervous system, pupae P8    51 head, virgin 1-day female    21 head, virgin 4-day female    23 head, virgin 20-day female    18 head, mated 1-day female    23 head, mated 4-day female    27 head, mated 20-day female    16 head, mated 1-day male    32 head, mated 4-day male    35 head, mated 20-day male    33 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    11 digestive system, larvae L3 wandering    12 digestive system, 1-day adult    11 digestive system, 4-day adult    18 digestive system, 20-day adult    15 fat body, larvae L3 wandering    9 fat body, white prepupae    23 fat body, pupae P8    19 carcass, larvae L3 wandering    45 carcass, 1-day adult    15 carcass, 4-day adult    19 carcass, 20-day adult    14 ovary, virgin 4-day female    94 ovary, mated 4-day female    105 testis, mated 4-day male    19 accessory gland, mated 4-day male    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    156 embryo 04-06hr    134 embryo 06-08hr    115 embryo 08-10hr    101 embryo 10-12hr    69 embryo 12-14hr    63 embryo 14-16hr    57 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    68 embryo 22-24hr    54 larva L1    27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    41 white prepupae 24hr    49 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day    34 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (99) embryo 02-04hr  (156) embryo 04-06hr  (134) embryo 06-08hr  (115) embryo 08-10hr  (101) embryo 10-12hr  (69) embryo 12-14hr  (63) embryo 14-16hr  (57) embryo 16-18hr  (45) embryo 18-20hr  (33) embryo 20-22hr  (68) embryo 22-24hr  (54) larva L1  (27) larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9  26 white prepupae new  (31) white prepupae 12hr  (41) white prepupae 24hr  (49) pupae 2d postWPP  (29) pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day  (34) adult female 05day  (58) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr  (156) embryo 04-06hr  (134) embryo 06-08hr  (115) embryo 08-10hr  101 embryo 10-12hr    69 embryo 12-14hr    63 embryo 14-16hr    57 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    68 embryo 22-24hr    54 larva L1    27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    41 white prepupae 24hr    49 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day    34 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    156 embryo 04-06hr    134 embryo 06-08hr    115 embryo 08-10hr    101 embryo 10-12hr    69 embryo 12-14hr    63 embryo 14-16hr    57 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    68 embryo 22-24hr    54 larva L1    27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    41 white prepupae 24hr    49 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day    34 adult female 05day    58 adult female 30day    57 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    156 embryo 04-06hr    134 embryo 06-08hr    115 embryo 08-10hr    101 embryo 10-12hr    69 embryo 12-14hr    63 embryo 14-16hr    57 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    68 embryo 22-24hr    54 larva L1    27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    41 white prepupae 24hr    49 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day    34 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (99) embryo 02-04hr  (156) embryo 04-06hr  (134) embryo 06-08hr  (115) embryo 08-10hr  (101) embryo 10-12hr  (69) embryo 12-14hr  (63) embryo 14-16hr  (57) embryo 16-18hr  (45) embryo 18-20hr  (33) embryo 20-22hr  (68) embryo 22-24hr  (54) larva L1  27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9  26 white prepupae new  31 white prepupae 12hr  (41) white prepupae 24hr  (49) pupae 2d postWPP  29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day  (34) adult female 05day  (58) adult female 30day  (57) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr  (156) embryo 04-06hr  134 embryo 06-08hr  115 embryo 08-10hr  101 embryo 10-12hr    69 embryo 12-14hr    63 embryo 14-16hr    57 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    68 embryo 22-24hr    54 larva L1    27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    41 white prepupae 24hr    49 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day    34 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    99 embryo 02-04hr    156 embryo 04-06hr    134 embryo 06-08hr    115 embryo 08-10hr    101 embryo 10-12hr    69 embryo 12-14hr    63 embryo 14-16hr    57 embryo 16-18hr    45 embryo 18-20hr    33 embryo 20-22hr    68 embryo 22-24hr    54 larva L1    27 larva L2    19 larva L3 12hr old    16 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    25 larva L3 puffstage 7-9    26 white prepupae new    31 white prepupae 12hr    41 white prepupae 24hr    49 pupae 2d postWPP    29 pupae 3d postWPP    17 pupae 4d postWPP    13 adult male 01day    16 adult male 05day    19 adult male 30day    18 adult female 01day    34 adult female 05day    58 adult female 30day    57 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    37 embryonic 1182-4H    52 embryonic GM2    56 embryonic Kc167    34 embryonic S1    63 embryonic S3    37 leg disc CME L1    51 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    72 wing disc ML-DmD21    17 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    45 ovary fGS/OSS    90 ovary OSC    113 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (37) embryonic 1182-4H  (52) embryonic GM2  (56) embryonic Kc167  (34) embryonic S1  (63) embryonic S3  (37) leg disc CME L1  (51) wing disc CME-W2  (36) wing disc ML-DmD8  (41) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (72) wing disc ML-DmD21    17 wing disc ML-DmD32  (60) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (51) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (66) CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2  (45) ovary fGS/OSS  (90) ovary OSC  (113) ovary OSS  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    37 embryonic 1182-4H    52 embryonic GM2    56 embryonic Kc167    34 embryonic S1    63 embryonic S3    37 leg disc CME L1    51 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    72 wing disc ML-DmD21    17 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    45 ovary fGS/OSS    90 ovary OSC  (113) ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    37 embryonic 1182-4H    52 embryonic GM2    56 embryonic Kc167    34 embryonic S1    63 embryonic S3    37 leg disc CME L1    51 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    72 wing disc ML-DmD21    17 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    45 ovary fGS/OSS    90 ovary OSC    113 ovary OSS    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    37 embryonic 1182-4H    52 embryonic GM2    56 embryonic Kc167    34 embryonic S1    63 embryonic S3    37 leg disc CME L1    51 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    72 wing disc ML-DmD21    17 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    45 ovary fGS/OSS    90 ovary OSC    113 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (64) Schneider line 2 Sg4  (37) embryonic 1182-4H  (52) embryonic GM2  (56) embryonic Kc167  (34) embryonic S1  (63) embryonic S3  (37) leg disc CME L1  (51) wing disc CME-W2  (36) wing disc ML-DmD8  (41) wing disc ML-DmD9  (53) wing disc ML-DmD16-c3  (72) wing disc ML-DmD21    17 wing disc ML-DmD32  (60) haltere disc ML-DmD17-c3  (49) eye-antennal disc ML-DmD11  (51) antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (66) CNS ML-DmBG2-c2  (71) tumorous blood cells mbn2  (45) ovary fGS/OSS  (90) ovary OSC  (113) ovary OSS  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    37 embryonic 1182-4H    52 embryonic GM2    56 embryonic Kc167    34 embryonic S1    63 embryonic S3    37 leg disc CME L1    51 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    72 wing disc ML-DmD21    17 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    45 ovary fGS/OSS    90 ovary OSC  113 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    64 Schneider line 2 Sg4    37 embryonic 1182-4H    52 embryonic GM2    56 embryonic Kc167    34 embryonic S1    63 embryonic S3    37 leg disc CME L1    51 wing disc CME-W2    36 wing disc ML-DmD8    41 wing disc ML-DmD9    53 wing disc ML-DmD16-c3    72 wing disc ML-DmD21    17 wing disc ML-DmD32    60 haltere disc ML-DmD17-c3    49 eye-antennal disc ML-DmD11    51 antennal disc ML-DmD20-c5    20 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    66 CNS ML-DmBG2-c2    71 tumorous blood cells mbn2    45 ovary fGS/OSS    90 ovary OSC    113 ovary OSS    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    34 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    79 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    55 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    63 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (44) cold shock, 4-day adult  (34) heat shock, 4-day adult  (37) Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult  (79) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (55) Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  (31) Ethanol 2.5% 3 hrs, larvae L3  (74) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (63) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (57) Paraquat 10 mM 48 hrs, 4-day adult  (56) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    34 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    79 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    55 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    63 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    34 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    79 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    55 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    63 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    34 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    79 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    55 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    63 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (44) cold shock, 4-day adult  (34) heat shock, 4-day adult  (37) Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult  (35) Cadmium 100 mM 48 hrs, 4-day adult  (79) Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult  (55) Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult  31 Ethanol 2.5% 3 hrs, larvae L3  (74) Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (63) Caffeine 25 mg/ml 48 hrs, 4-day adult  (42) Paraquat 5 mM 48 hrs, 4-day adult  (57) Paraquat 10 mM 48 hrs, 4-day adult  (56) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    34 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    79 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    55 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    63 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    34 heat shock, 4-day adult    37 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    35 Cadmium 100 mM 48 hrs, 4-day adult    79 Copper 0.5 mM 12 hrs, larvae L3    20 Copper 15 mM 48 hrs, 4-day adult    55 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    31 Ethanol 2.5% 3 hrs, larvae L3    74 Ethanol 5% 3 hrs, larvae L3    10 Ethanol 10% 3 hrs, larvae L3    10 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    63 Caffeine 25 mg/ml 48 hrs, 4-day adult    42 Paraquat 5 mM 48 hrs, 4-day adult    57 Paraquat 10 mM 48 hrs, 4-day adult    56 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035357 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1244-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive MEP-1GTD74-56 Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of MEP-1 Class Mutagen Stocks Known lesion MEP-15-HA-1819 1 -- MEP-1C240 1 -- MEP-1EY04917 P-element activity 1 -- MEP-1f05384 piggyBac transposase 1 -- MEP-1GTD74-56 P-element activity 1 Yes MEP-1CPTI003583 piggyBac transposase 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of MEP-1 Class Mutagen Stocks Known lesion MEP-1GD7728 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes MEP-1GL00319 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes MEP-1HMS00540 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{TRiP.GL00319} NA P{TRiP.HMS00540} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GTD-b}MEP-1GTD74-56 NA P{RS5}MEP-15-HA-1819 NA PBac{3HPy+}MEP-1C240 NA PBac{768.FSVS-0}MEP-1CPTI003583 NA PBac{WH}MEP-1f05384 NA insertion of mobile activating element P{EPgy2}MEP-1EY04917 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Kunert et al., 2009) contributes_to nucleosome-dependent ATPase activity inferred from direct assay (Kunert et al., 2009) protein binding inferred from physical interaction with Mi-2 (Kunert et al., 2009)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) negative regulation of transcription from RNA polymerase II promoter inferred from direct assay (Kunert et al., 2009)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Kunert et al., 2009) NuRD complex inferred from physical interaction with Mi-2 (Reddy et al., 2010) polytene chromosome inferred from direct assay (Reddy et al., 2010)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	gene_with_dicistronic_mRNA (FlyBase Genome Annotators, 2008) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
MEP-1 - CG6652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MEP-1 - Tsp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) MEP-1 - grau anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions MEP-1 allele Gene References unspecified sens (Parrish et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63832 DroID - A comprehensive database of gene and protein interactions. • FBgn0035357 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38327
Orthologs
OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WM5D3 Dipteran inclusive ortholog search EOG6SF9F1 Insect inclusive ortholog search EOG6SJ48R Arthropod inclusive ortholog search EOG6Z613G Metazoa inclusive ortholog search EOG6R5BW1
Orthologs in Drosophila Species (EOG6WM5D3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\MEP-1     Drosophila simulans   Dsim\GD13699 Y   Drosophila sechellia   Dsec\GM14502 Y   Drosophila erecta   Dere\GG14878 Y   Drosophila yakuba   Dyak\GE20330 Y   Drosophila ananassae   Dana\GF24240 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11636 Y   Drosophila persimilis   Dper\GL22463 Y   Drosophila willistoni   Dwil\GK12660 Y   Drosophila virilis   Dvir\GJ12382 Y   Drosophila mojavensis   Dmoj\GI12479 Y   Drosophila grimshawi   Dgri\GH16396 Y
Orthologs in non-Drosophila Dipterans (EOG6SF9F1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014168   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004838   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013509
Orthologs in non-Dipteran Insects (EOG6SJ48R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46509   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014961   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10388   Atta cephalotes Leafcutter ant  Acep\ACEP10503   Camponotus floridanus Florida carpenter ant  Cflo\CFLO23336   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14381   Linepithema humile Argentine ant  Lhum\LH22215   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11141   Solenopsis invicta Red fire ant  Sinv\SINV11169   Solenopsis invicta Red fire ant  Sinv\SINV19445   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001659   Acyrthosiphon pisum Pea aphid  Apim\ACYPI069417   Bombyx mori Silkmoth  Bmor\BGIBMGA013147   Bombyx mori Silkmoth  Bmor\BGIBMGA000537   Pediculus humanus Human body louse  Phum\PHUM538050   Tribolium castaneum Red flour beetle  Tcas\TC002395
Orthologs in non-Insect Arthropods (EOG6Z613G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_196289   Ixodes scapularis Deer tick  Isca\ISCW001691
Orthologs in non-Arthropod Metazoa (EOG6R5BW1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mep-1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13699 Drosophila sechellia Dsec\GM14502 Drosophila erecta Dere\GG14878 Drosophila yakuba Dyak\GE20330 Drosophila ananassae Dana\GF24240 Drosophila pseudoobscura pseudoobscura Dpse\GA11636 Drosophila persimilis Dper\GL22463 Drosophila willistoni Dwil\GK12660 Drosophila virilis Dvir\GJ12382 Drosophila mojavensis Dmoj\GI12479 Drosophila grimshawi Dgri\GH16396
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	15774 y1 w67c23; P{EPgy2}MEP-1EY04917 35399 y1 sc* v1; P{TRiP.GL00319}attP2 16316 y1 w1118; PBac{3HPy+}MEP-1C240 33676 y1 sc* v1; P{TRiP.HMS00540}attP2/TM3, Sb1
Harvard	- PBac{WH}MEP-1f05384
Kyoto	109068 P{GTD-b}MEP-1GTD74-56 125412 w1118; P{RS5}MEP-15-HA-1819
VDRC	v24533 w1118 P{GD7728}v24533 v24534 w1118; P{GD7728}v24534
Genomic Clones ( 1 )
	BACR27A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 194 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22412 RE60032
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT16816 GH01713 GH04796 GH05069 GH11755 GM04139 GM16118 GM22759 GM24025 HL01345 LD03723 LD03754 LD04305 LD04704 LD05662 LD06211 LD06872 LD07938 LD10227 LD10594 LD11727 LD11910 LD12540 LD12863 LD12976 LD13110 LD13740 LD14091 LD14111 LD14308 LD14695 LD16586 LD16663 LD18467 LD18519 LD20679 LD21368 LD22309 LD22783 LD22791 LD23032 LD23357 LD24348 LD25158 LD26015 LD28509 LD28510 LD32794 LD38357 LD40352 LD41046 LD42089 LD45282 LD47487 LD47704 LP04667 LP12672 LP19620 RE04067 RE23553 RE34445 RE37909 RE49334 RE49346 RE51234 RE51246 RE55323 RE56124 RE56145 RE63390 RE67434 SD04453 SD04558 SD05187 SD07193 SD07293 SD09504 SD10688 SD17494 SD25502 UT01729
Other clones	648 13318 20044 39528 44978 57346 70044 71822 73825 101133 108397 146521 147443 147829 157022 177411 178637 178849 275054 280844 AI124269 CK01.53D.E12 CK01.83D.C11 CK01.103B.H9 CK01.106A.E7 CK01.116C.H10 CK01041 Dmel_dig_004196_0661_0690 Dmel_neb_010970_0629_0879 Dmel_neb_011661_0672_1004 Dmel_neb_012942_0435_0667 Dmel_neb_014956_0616_1600 EK043352 EK066810 EK086829 EK088520 EK121824 EK134011 EK160654 EK164517 EK165840 EK173024 EK177436 EK197251 EK224021 EK235201 EK250516 EK252959 EK270445 EK282511 EK283640 EK305637 FGA009E01 FGC002B08 FGM102E10 FGM315G10 LD03480 LD41291 LD43553 RP01453 RP001000002 RP001001927 RP001003309 RP001004159 RP001005522 RP001006386 RP001006703 RP001008508 RP001008759 RP001009490 RP001012807 RP001016703 RP001016782 RP001017229 RP001018790 RP001019393 RP001022626 RP001022874 RP001022916 RP001023401 RP001024351 RP001024892 RP001025657 RP001025980 RP001026422 RP001026512 RP001029887 RP001033294 RP001035146 RP001035294 RP001035483 RP001036987 RP001038102 RP001039361 RP001040824 RP001041972 RP001042969 RP001042992 RP001044221 RP001047204 RP001048092 RP001048184 RP001049390 RP001049978 RP001050820 RP001051834 RP001052194 RP001052337 RP001054493 RP001055044 RP001055978
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035357 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38327
Antibody Information
	monoclonal (Kunert et al., 2009) polyclonal (Kunert et al., 2009, Reddy et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: MEP-1 CG1244 (Stielow et al., 2008)
Source for database merge of	Source for merge of: CG1244 anon-EST:Liang-1.37 (FlyBase, 1996-) Source for merge of: CG1244 anon-WO0118547.584 (FlyBase, 1996-)
Additional comments	One or more of the processed transcripts for these genes contain two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by CG42245 (FBgn0250911), CG1244 (FBgn0035357). (FlyBase Genome Annotators, 2008) Source for merge of CG1244 anon-WO0118547.584 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of CG1244 anon-EST:Liang-1.37 was sequence comparison (date:030722). (FlyBase, 1996-)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for MEP-1 protein in S2 cells; GEO accession number GSE32404. (Moshkin et al., 2012) dsRNA has been made from templates generated with primers directed against this gene. RNAi of CG1244 disrupts the dendritic routing patterns of the ddaD and ddaE neurons, resulting in aberrantly oriented primary dendrites. The overall arborization of these neurons is reduced. Additionally, RNAi causes defects in dendrite morphogenesis. (Parrish et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139476 NM_167958 NM_167959 NM_167960 NM_167961 NM_167962 NM_001144403 RefSeq (Proteins) • NP_647733 NP_728761 NP_728762 NP_728763 NP_728764 NP_728765 NP_001137875 DDBJ / EMBL / GenBank • AA817226 AA941806 AAF47669 AAF47670 AAG22230 AAG22231 AAL39644 AAN11519 AAN11520 ACL83231 AI124269 AW942638 AX094460 AY069499 BI372846 CZ487945 Entrez Gene - A searchable database of RefSeq genes. • 38327 UniProtKB/TrEMBL • Q0E8J0 Q8T078
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, C2H2-like (IPR015880)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63832 DroID - A comprehensive database of gene and protein interactions. • FBgn0035357 DRSC - Results from RNAi screens. • FBgn0035357 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035357 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1244-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035357 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38327 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38327 modMine - Data generated by the modENCODE project. • FBgn0035357
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-EST:Liang-1.37   anon-WO0118547.584   CG1244 (Gan et al., 2010, Parrish et al., 2006, FlyBase Genome Annotators, 2008, Stielow et al., 2008, Jacques et al., 2009, Reddy et al., 2010, Ni et al., 2010.12.1, Ni et al., 2011.7.19) clone 1.37 (Liang and Biggin, 1998) dMEP-1 (Kunert et al., 2009) MEP-1 (Stielow et al., 2008, Toku et al., 2011, ) MEP1 (Reddy et al., 2010, Moshkin et al., 2012) Q0E8J0_DROME (Fukuyama et al., 2012)
Name Synonym	CG1244 (FlyBase Genome Annotators, 2008)
Secondary FlyBase IDs
	FBgn0025995 FBgn0061858
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 2 ) Personal communication to FlyBase  ( 11 ) FlyBase analysis  ( 4 ) Patent  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Fukuyama et al., 2012, J. Proteomics 75(15): 4610--4619 On-bead tryptic proteolysis: An attractive procedure for LC-MS/MS analysis of the Drosophila caspase 8 protein complex during immune response against bacteria. [FBrf0218992] Moshkin et al., 2012, Mol. Cell. Biol. 32(3): 675--688 Remodelers Organize Cellular Chromatin by Counteracting Intrinsic Histone-DNA Sequence Preferences in a Class-Specific Manner. [FBrf0217223] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Show all research papers ...