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Gene Dmel\mRpS35

General Information
Symbol	Dmel\mRpS35	Species	D. melanogaster
Name	mitochondrial ribosomal protein S35	Annotation symbol	CG2101
Feature type	protein_coding_gene	FlyBase ID	FBgn0035374
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62F4-62F4	Sequence location	3L:2,780,899..2,782,105 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ribosomal protein S35 is referred to in FlyBase by the symbol Dmel\mRpS35 (CG2101, FBgn0035374). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 4 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein S24/S35, mitochondrial, conserved domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632280_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpS35. Gene sequence location is 3L:2780899..2782105.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62F4-62F4   Limits computationally determined from genome sequence between P{PZ}Spn06911 and P{PZ}l(3)0680306803
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mRpS35 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mRpS35-RA FBtr0301626  NM_079169   1144   326
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mRpS35-PA   FBpp0290840   37.7   326   9.44     NP_523893   AAF47688
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S24/S35, mitochondrial, conserved domain (IPR019349)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263309   AE014296 AAF47688   BI352170   BI633029   BT016117   CO282211   EC213715   EC222463   EL876721
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZX6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    206.425 Larval Midgut    114.7 Larval Hindgut    237.7 Larval Malpighian Tubules    66.8 Larval Fat Body    63.9 Larval Salivary Gland    166.9 Larval Trachea    139.425 Larval Carcass    135.95 Adult Head    142.1 Adult Eye    177.625 Adult Brain    218.3 Adult Thoracic-Abdominal Ganglion    251.8 Adult Crop    152.5 Adult Midgut    123.6 Adult Hindgut    216.8 Adult Malpighian Tubules    88.6 Adult Fat Body    124.2 Adult Salivary Gland    136.3 Adult Heart    138.925 Adult VirginFemale Spermatheca    126.7 Adult InseminatedFemale Spermatheca    138.1 Adult Ovary    309.1 Adult Testis    45.9 Adult Male Accessory Gland    121.4 Adult Carcass    127.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    142.1   NA  Eye    177.625   NA  Brain    218.3   206.425  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    251.8   NA  Crop    152.5   114.7  Midgut    123.6   237.7  Hindgut    216.8   66.8  Malpighian Tubules    88.6   63.9  Fat Body    124.2   166.9  Salivary Gland    136.3   NA  Heart    138.925   139.425  Trachea    NA   NA  VirginFemale Spermatheca    126.7   NA  InseminatedFemale Spermatheca    138.1   NA  Ovary    309.1   NA  Testis    45.9   NA  Male Accessory Gland    121.4   135.95  Carcass    127.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    30 ovary, mated 4-day female    28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female  (30) ovary, mated 4-day female  (28) testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    30 ovary, mated 4-day female    28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    30 ovary, mated 4-day female    28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    30 ovary, mated 4-day female    28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female  30 ovary, mated 4-day female  28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    30 ovary, mated 4-day female    28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    18 central nervous system, larvae L3    13 central nervous system, pupae P8    11 head, virgin 1-day female    11 head, virgin 4-day female    11 head, virgin 20-day female    7 head, mated 1-day female    13 head, mated 4-day female    10 head, mated 20-day female    7 head, mated 1-day male    10 head, mated 4-day male    14 head, mated 20-day male    14 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    15 digestive system, 4-day adult    17 digestive system, 20-day adult    13 fat body, larvae L3 wandering    3 fat body, white prepupae    3 fat body, pupae P8    18 carcass, larvae L3 wandering    9 carcass, 1-day adult    9 carcass, 4-day adult    13 carcass, 20-day adult    10 ovary, virgin 4-day female    30 ovary, mated 4-day female    28 testis, mated 4-day male    14 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 06-12 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    17 embryo 04-06hr    33 embryo 06-08hr    32 embryo 08-10hr    32 embryo 10-12hr    56 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    38 embryo 18-20hr    37 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    50 larva L2    54 larva L3 12hr old    42 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP    28 pupae 3d postWPP    38 pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    31 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr    17 embryo 04-06hr  (33) embryo 06-08hr  (32) embryo 08-10hr  (32) embryo 10-12hr  (56) embryo 12-14hr  (33) embryo 14-16hr  (39) embryo 16-18hr  (38) embryo 18-20hr  (37) embryo 20-22hr  (32) embryo 22-24hr  (27) larva L1  (50) larva L2  (54) larva L3 12hr old  (42) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP  (28) pupae 3d postWPP  (38) pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day  (31) adult female 05day  (38) adult female 30day  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    17 embryo 04-06hr    33 embryo 06-08hr    32 embryo 08-10hr    32 embryo 10-12hr    56 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    38 embryo 18-20hr    37 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    50 larva L2    54 larva L3 12hr old    42 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP    28 pupae 3d postWPP    38 pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    31 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    17 embryo 04-06hr    33 embryo 06-08hr    32 embryo 08-10hr    32 embryo 10-12hr    56 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    38 embryo 18-20hr    37 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    50 larva L2    54 larva L3 12hr old    42 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP    28 pupae 3d postWPP    38 pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    31 adult female 05day    38 adult female 30day    41 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    17 embryo 04-06hr    33 embryo 06-08hr    32 embryo 08-10hr    32 embryo 10-12hr    56 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    38 embryo 18-20hr    37 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    50 larva L2    54 larva L3 12hr old    42 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP    28 pupae 3d postWPP    38 pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    31 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (37) embryo 02-04hr    17 embryo 04-06hr  (33) embryo 06-08hr  32 embryo 08-10hr  32 embryo 10-12hr  (56) embryo 12-14hr  (33) embryo 14-16hr  (39) embryo 16-18hr  (38) embryo 18-20hr  (37) embryo 20-22hr  32 embryo 22-24hr  27 larva L1  (50) larva L2  (54) larva L3 12hr old  (42) larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP  28 pupae 3d postWPP  (38) pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day  31 adult female 05day  (38) adult female 30day  (41) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    17 embryo 04-06hr    33 embryo 06-08hr    32 embryo 08-10hr    32 embryo 10-12hr    56 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    38 embryo 18-20hr    37 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    50 larva L2    54 larva L3 12hr old    42 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP    28 pupae 3d postWPP    38 pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    31 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    37 embryo 02-04hr    17 embryo 04-06hr    33 embryo 06-08hr    32 embryo 08-10hr    32 embryo 10-12hr    56 embryo 12-14hr    33 embryo 14-16hr    39 embryo 16-18hr    38 embryo 18-20hr    37 embryo 20-22hr    32 embryo 22-24hr    27 larva L1    50 larva L2    54 larva L3 12hr old    42 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    12 white prepupae 24hr    11 pupae 2d postWPP    28 pupae 3d postWPP    38 pupae 4d postWPP    16 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    31 adult female 05day    38 adult female 30day    41 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    61 embryonic 1182-4H    32 embryonic GM2    22 embryonic Kc167    49 embryonic S1    25 embryonic S3    38 leg disc CME L1    42 wing disc CME-W2    28 wing disc ML-DmD8    26 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    59 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    31 ovary fGS/OSS    22 ovary OSC    29 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (86) Schneider line 2 Sg4  (61) embryonic 1182-4H  (32) embryonic GM2    22 embryonic Kc167  (49) embryonic S1    25 embryonic S3  (38) leg disc CME L1  (42) wing disc CME-W2  (28) wing disc ML-DmD8  26 wing disc ML-DmD9  (30) wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (59) wing disc ML-DmD32    10 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (46) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  (31) ovary fGS/OSS    22 ovary OSC  (29) ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    61 embryonic 1182-4H    32 embryonic GM2    22 embryonic Kc167    49 embryonic S1    25 embryonic S3    38 leg disc CME L1    42 wing disc CME-W2    28 wing disc ML-DmD8    26 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    59 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    31 ovary fGS/OSS    22 ovary OSC    29 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    61 embryonic 1182-4H    32 embryonic GM2    22 embryonic Kc167    49 embryonic S1    25 embryonic S3    38 leg disc CME L1    42 wing disc CME-W2    28 wing disc ML-DmD8    26 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    59 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    31 ovary fGS/OSS    22 ovary OSC    29 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    61 embryonic 1182-4H    32 embryonic GM2    22 embryonic Kc167    49 embryonic S1    25 embryonic S3    38 leg disc CME L1    42 wing disc CME-W2    28 wing disc ML-DmD8    26 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    59 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    31 ovary fGS/OSS    22 ovary OSC    29 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (86) Schneider line 2 Sg4  (61) embryonic 1182-4H  32 embryonic GM2    22 embryonic Kc167  (49) embryonic S1    25 embryonic S3  (38) leg disc CME L1  (42) wing disc CME-W2  28 wing disc ML-DmD8  26 wing disc ML-DmD9  30 wing disc ML-DmD16-c3  (34) wing disc ML-DmD21  (59) wing disc ML-DmD32    10 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (35) CNS ML-DmBG1-c1  (46) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2  31 ovary fGS/OSS    22 ovary OSC  29 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    61 embryonic 1182-4H    32 embryonic GM2    22 embryonic Kc167    49 embryonic S1    25 embryonic S3    38 leg disc CME L1    42 wing disc CME-W2    28 wing disc ML-DmD8    26 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    59 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    31 ovary fGS/OSS    22 ovary OSC    29 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    86 Schneider line 2 Sg4    61 embryonic 1182-4H    32 embryonic GM2    22 embryonic Kc167    49 embryonic S1    25 embryonic S3    38 leg disc CME L1    42 wing disc CME-W2    28 wing disc ML-DmD8    26 wing disc ML-DmD9    30 wing disc ML-DmD16-c3    34 wing disc ML-DmD21    59 wing disc ML-DmD32    10 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    35 CNS ML-DmBG1-c1    46 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    31 ovary fGS/OSS    22 ovary OSC    29 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (34) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3  (29) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (34) Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3  29 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    8 cold shock, 4-day adult    5 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    23 Cadmium 50 mM 12 hrs, larvae L3    11 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    24 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    34 Zinc 5 mM 12 hrs, larvae L3    10 Zinc 4.5 mM 48 hrs, 4-day adult    22 Ethanol 2.5% 3 hrs, larvae L3    25 Ethanol 5% 3 hrs, larvae L3    22 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    18 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    24 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    18 Rotenone 8 μg 12 hrs, larvae L3    29 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035374 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2101-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 mRpS35GD9724 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mRpS35GD9724 Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 mRpS35GD9724 trichogen cell, with Scer\GAL4pnr-MD237 mRpS35GD9724
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of mRpS35 Class Mutagen Stocks Known lesion mRpS35f02546b 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mRpS35 Class Mutagen Stocks Known lesion mRpS35GD9724 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mRpS35KK107840 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mRpS35NIG.2101R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6091 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9724} NA P{KK107840} NA P{NIG.2101R} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}mRpS35f02546b NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with UniProtKB:Q9Y2Q9 (Koc et al., 2001)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with UniProtKB:Q9Y2Q9 (Koc et al., 2001)
Cellular Component
CV term Evidence References
mitochondrial small ribosomal subunit inferred from sequence or structural similarity with UniProtKB:Q9Y2Q9 (Koc et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mRpS35 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63847 DroID - A comprehensive database of gene and protein interactions. • FBgn0035374 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38345
Orthologs
OrthoDB Orthologs (42) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6H72XR Dipteran inclusive ortholog search EOG6GMV5T Insect inclusive ortholog search EOG67WMJK Arthropod inclusive ortholog search EOG6KWH8N Metazoa inclusive ortholog search EOG63VBPN
Orthologs in Drosophila Species (EOG6H72XR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mRpS35     Drosophila simulans   Dsim\GD13711 Y   Drosophila sechellia   Dsec\GM14514 Y   Drosophila erecta   Dere\GG14888 Y   Drosophila yakuba   Dyak\GE20339 Y   Drosophila ananassae   Dana\GF24249 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15241 Y   Drosophila persimilis   Dper\GL22637 Y   Drosophila willistoni   Dwil\GK16569 Y   Drosophila virilis   Dvir\GJ13595 Y   Drosophila mojavensis   Dmoj\GI11400 Y   Drosophila grimshawi   Dgri\GH16988 Y
Orthologs in non-Drosophila Dipterans (EOG6GMV5T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009217   Anopheles gambiae Malaria mosquito  Agam\AGAP006802   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004543
Orthologs in non-Dipteran Insects (EOG67WMJK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\mRpS35   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014908   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17519   Atta cephalotes Leafcutter ant  Acep\ACEP12947   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18206   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16779   Linepithema humile Argentine ant  Lhum\LH19296   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18329   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006842   Bombyx mori Silkmoth  Bmor\BGIBMGA001805   Pediculus humanus Human body louse  Phum\PHUM425140   Tribolium castaneum Red flour beetle  Tcas\TC003669
Orthologs in non-Insect Arthropods (EOG6KWH8N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_316038   Daphnia pulex Water flea  Dpux\JGI_V11_49266   Daphnia pulex Water flea  Dpux\Mageb3   Daphnia pulex Water flea  Dpux\COI   Daphnia pulex Water flea  Dpux\JGI_V11_240975   Daphnia pulex Water flea  Dpux\nad5   Ixodes scapularis Deer tick  Isca\ISCW008744
Orthologs in non-Arthropod Metazoa (EOG63VBPN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mrps-35   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022351gn   Danio rerio Zebrafish  Drer\zgc:114150   Xenopus tropicalis Western clawed frog  Xtro\mrps35   Gallus gallus Domestic chicken  Ggal\MRPS35   Mus musculus House mouse  Mmus\ENSMUSG00000040112   Rattus norvegicus Norway rat  Rnor\Mrps35   Homo sapiens Human  Hsap\MRPS35
Human Orthologs (1)
Gene OMIM HGNC Hsap\MRPS35
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13711 Drosophila sechellia Dsec\GM14514 Drosophila erecta Dere\GG14888 Drosophila yakuba Dyak\GE20339 Drosophila ananassae Dana\GF24249 Drosophila pseudoobscura pseudoobscura Dpse\GA15241 Drosophila persimilis Dper\GL22637 Drosophila willistoni Dwil\GK16569 Drosophila virilis Dvir\GJ13595 Drosophila mojavensis Dmoj\GI11400 Drosophila grimshawi Dgri\GH16988
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Harvard	- PBac{WH}f02546a, PBac{WH}mRpS35f02546b
VDRC	v104882 P{KK107840}VIE-260B v33473 w1118; P{GD9724}v33473 v33474 w1118; P{GD9724}v33474/TM3
Genomic Clones ( 1 )
	BACR09N02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 7 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD06441
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM18169 SD26984
Other clones	44686 103380 EK159816 IP06648
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035374 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38345
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: MRP-S28 CG2101 (Koc et al., 2001)
Source for database merge of
Additional comments	FlyBase curator comment: the insertion in the "e02239" Exelixis line (PBac{RB}mRpS28e02239) was originally assigned to the mRpS35 gene in FBrf0179797, resulting in the "mRpS35e02239" (FBal0158978) allele. However, FBrf0184340 shows that the insertion is actually within mRpS28. FlyBase curator comment: the insertion in the "f03356" Exelixis line (PBac{WH}mRpS28f03356) was originally assigned to the mRpS35 gene in FBrf0179797, resulting in the "mRpS35f03356" (FBal0158977) allele. However, BLAST shows that the insertion is actually within mRpS28. (Bloomington Drosophila Stock Center, 2004.11.6)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079169 RefSeq (Proteins) • NP_523893 DDBJ / EMBL / GenBank • AA263309 AAF47688 Entrez Gene - A searchable database of RefSeq genes. • 38345 UniProtKB/TrEMBL • Q9VZX6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein S24/S35, mitochondrial, conserved domain (IPR019349)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63847 DroID - A comprehensive database of gene and protein interactions. • FBgn0035374 DRSC - Results from RNAi screens. • FBgn0035374 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035374 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2101-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035374 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38345 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38345 modMine - Data generated by the modENCODE project. • FBgn0035374
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG2101 (Keleman et al., 2009.8.5, Wittkopp et al., 2008, Marygold et al., 2007, Cammarato et al., 2011) MRP-S28 (Koc et al., 2001) mRpS35 (Wittkopp et al., 2008, Marygold et al., 2007, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	mitochondrial ribosomal protein S35 (Marygold, 2004.9.8, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 18 )
Research paper	Casad et al., 2011, Genetics 189(3): 861--870 Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591] Marygold et al., 2007, Genome Biol. 8(10): R216 The ribosomal protein genes and Minute loci of Drosophila melanogaster. [FBrf0205398] Koc et al., 2001, J. Biol. Chem. 276(22): 19363--19374 The small subunit of the mammalian mitochondrial ribosome: Identification of the full complement of ribosomal proteins present. [FBrf0136744]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Wittkopp et al., 2008, Nat. Genet. 40(3): Supplementary Information [FBrf0208881] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797] Marygold, 2004.9.8, Ribosomal protein nomenclature in D.melanogaster. Ribosomal protein nomenclature in D.melanogaster. [FBrf0179760] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
Stock list	Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY. RNAi stocks available from NIG-FLY. [FBrf0218457]