Gene Dmel\CG12082

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General Information

Symbol

Dmel\CG12082

Species

D. melanogaster

Name

Annotation symbol

CG12082

Feature type

protein_coding_gene

FlyBase ID

FBgn0035402

Gene Model Status

Current

Stock availability

5 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

63B6-63B7

Sequence location

3L:3,145,405..3,148,358 [-]

Genomic Maps

Select View:

modENCODE GBrowse

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG12082 (FBgn0035402). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ubiquitin thiolesterase activity. It is reported to be involved in the biological process: protein deubiquitination. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2; Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site; UBA-like; Ubiquitin-associated/translation elongation factor EF1B, N-terminal; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote; Ubiquitinyl hydrolase; Zinc finger, RING/FYVE/PHD-type; Zinc finger, UBP-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1630178_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG12082. Gene sequence location is 3L:3145405..3148358.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2011_10

References

Zhang et al., 2008, BMC Bioinformatics 9: 129

Controlled Vocabulary Terms

day 6 of adulthood

day 5 of adulthood

male

day 7 of adulthood

spermatozoon

FB2012_01

Sequence features

BKN20268

HFA08244

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

63B6-63B7

Limits computationally determined from genome sequence between P{PZ}l(3)06803⁰⁶⁸⁰³ and P{PZ}kst⁰¹³¹⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG12082 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.40

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG12082-RA

FBtr0073114

NM_139516

2779

827

CG12082-RB

FBtr0307308

2731

827

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG12082-PA

FBpp0072976

92.1

827

5.16

NP_647773

AAF47720

CG12082-PB

FBpp0298309

92.1

827

5.16

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ubiquitin-associated/translation elongation factor EF1B, N-terminal (IPR000449)

Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394)

Zinc finger, UBP-type (IPR001607)

UBA-like (IPR009060)

Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200)

Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940)

Ubiquitinyl hydrolase (IPR016652)

Zinc finger, RING/FYVE/PHD-type (IPR013083)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VZU7

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Untitled Document detailed view

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0035402

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	max expr for FBgn0035402
	Very low expression bin max
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No expression (0 - 0)
	Extremely low expression (1 - 10)
	Very low expression (11 - 100)
	Low expression (101 - 400)
	Moderate expression (401 - 1400)
	Moderately high expression (1401 - 4000)
	High expression (4001 - 10000)
	Very high expression (10001 - 100000)
	Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0035402 expression level
Developmental Stage		Expression Level
embryo 00-02hr		7457
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		3758
embryo 08-10hr		2804
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		3203
larva L3 puffstage 7-9		3488
white prepupae new		3857
white prepupae 12hr		2771
white prepupae 24hr		3487
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		3456
adult female 05day		5367
adult female 30day		5174
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High

Linear, scaled to Very low expression
Developmental Stage		Expression Level
embryo 00-02hr		(7457)
embryo 02-04hr		(809)
embryo 04-06hr		(1613)
embryo 06-08hr		(3758)
embryo 08-10hr		(2804)
embryo 10-12hr		(2298)
embryo 12-14hr		(1419)
embryo 14-16hr		(1122)
embryo 16-18hr		(538)
embryo 18-20hr		(330)
embryo 20-22hr		(179)
embryo 22-24hr		(196)
larva L1		(829)
larva L2		(1660)
larva L3 12hr old		(1739)
larva L3 puffstage 1-2		(1901)
larva L3 puffstage 3-6		(3203)
larva L3 puffstage 7-9		(3488)
white prepupae new		(3857)
white prepupae 12hr		(2771)
white prepupae 24hr		(3487)
pupae 2d postWPP		(1956)
pupae 3d postWPP		(1323)
pupae 4d postWPP		(1689)
adult male 01day		(1649)
adult male 05day		(1911)
adult male 30day		(1775)
adult female 01day		(3456)
adult female 05day		(5367)
adult female 30day		(5174)
Expression Level Scale		None Extremely low Very low Low

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(7457)
embryo 02-04hr		809
embryo 04-06hr		(1613)
embryo 06-08hr		(3758)
embryo 08-10hr		(2804)
embryo 10-12hr		(2298)
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		(1660)
larva L3 12hr old		(1739)
larva L3 puffstage 1-2		(1901)
larva L3 puffstage 3-6		(3203)
larva L3 puffstage 7-9		(3488)
white prepupae new		(3857)
white prepupae 12hr		(2771)
white prepupae 24hr		(3487)
pupae 2d postWPP		(1956)
pupae 3d postWPP		1323
pupae 4d postWPP		(1689)
adult male 01day		(1649)
adult male 05day		(1911)
adult male 30day		(1775)
adult female 01day		(3456)
adult female 05day		(5367)
adult female 30day		(5174)
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		7457
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		3758
embryo 08-10hr		2804
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		3203
larva L3 puffstage 7-9		3488
white prepupae new		3857
white prepupae 12hr		2771
white prepupae 24hr		3487
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		3456
adult female 05day		5367
adult female 30day		5174
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		7457
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		3758
embryo 08-10hr		2804
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		3203
larva L3 puffstage 7-9		3488
white prepupae new		3857
white prepupae 12hr		2771
white prepupae 24hr		3487
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		3456
adult female 05day		5367
adult female 30day		5174
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to maximum FBgn0035402 expression level
Developmental Stage		Expression Level
embryo 00-02hr		7457
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		3758
embryo 08-10hr		2804
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		3203
larva L3 puffstage 7-9		3488
white prepupae new		3857
white prepupae 12hr		2771
white prepupae 24hr		3487
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		3456
adult female 05day		5367
adult female 30day		5174
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

log, scaled to Very low expression
Developmental Stage		Expression Level
embryo 00-02hr		(7457)
embryo 02-04hr		(809)
embryo 04-06hr		(1613)
embryo 06-08hr		(3758)
embryo 08-10hr		(2804)
embryo 10-12hr		(2298)
embryo 12-14hr		(1419)
embryo 14-16hr		(1122)
embryo 16-18hr		(538)
embryo 18-20hr		(330)
embryo 20-22hr		(179)
embryo 22-24hr		(196)
larva L1		(829)
larva L2		(1660)
larva L3 12hr old		(1739)
larva L3 puffstage 1-2		(1901)
larva L3 puffstage 3-6		(3203)
larva L3 puffstage 7-9		(3488)
white prepupae new		(3857)
white prepupae 12hr		(2771)
white prepupae 24hr		(3487)
pupae 2d postWPP		(1956)
pupae 3d postWPP		(1323)
pupae 4d postWPP		(1689)
adult male 01day		(1649)
adult male 05day		(1911)
adult male 30day		(1775)
adult female 01day		(3456)
adult female 05day		(5367)
adult female 30day		(5174)
Expression Level Scale		None Extremely low Very low Low

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(7457)
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		(3758)
embryo 08-10hr		(2804)
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		(3203)
larva L3 puffstage 7-9		(3488)
white prepupae new		(3857)
white prepupae 12hr		(2771)
white prepupae 24hr		(3487)
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		(3456)
adult female 05day		(5367)
adult female 30day		(5174)
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		7457
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		3758
embryo 08-10hr		2804
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		3203
larva L3 puffstage 7-9		3488
white prepupae new		3857
white prepupae 12hr		2771
white prepupae 24hr		3487
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		3456
adult female 05day		5367
adult female 30day		5174
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		7457
embryo 02-04hr		809
embryo 04-06hr		1613
embryo 06-08hr		3758
embryo 08-10hr		2804
embryo 10-12hr		2298
embryo 12-14hr		1419
embryo 14-16hr		1122
embryo 16-18hr		538
embryo 18-20hr		330
embryo 20-22hr		179
embryo 22-24hr		196
larva L1		829
larva L2		1660
larva L3 12hr old		1739
larva L3 puffstage 1-2		1901
larva L3 puffstage 3-6		3203
larva L3 puffstage 7-9		3488
white prepupae new		3857
white prepupae 12hr		2771
white prepupae 24hr		3487
pupae 2d postWPP		1956
pupae 3d postWPP		1323
pupae 4d postWPP		1689
adult male 01day		1649
adult male 05day		1911
adult male 30day		1775
adult female 01day		3456
adult female 05day		5367
adult female 30day		5174
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

FlyAtlas Anatomical Expression Data for FBgn0035402

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	max expr for FBgn0035402
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0035402 expression level
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High Very high

log, scaled to maximum FBgn0035402 expression level
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		388.8
Larval Midgut		159
Larval Hindgut		187.4
Larval Malpighian Tubules		264.8
Larval Fat Body		206.4
Larval Salivary Gland		454.1
Larval Trachea		153.45
Larval Carcass		302.025
Adult Head		119.5
Adult Eye		89.45
Adult Brain		122.6
Adult Thoracic-Abdominal Ganglion		95.6
Adult Crop		106
Adult Midgut		139.7
Adult Hindgut		100.8
Adult Malpighian Tubules		139.1
Adult Fat Body		163.5
Adult Salivary Gland		117.3
Adult Heart		139.025
Adult VirginFemale Spermatheca		129.3
Adult InseminatedFemale Spermatheca		118.4
Adult Ovary		364.2
Adult Testis		156.6
Adult Male Accessory Gland		224
Adult Carcass		141.6
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	119.5
NA	Eye	89.45
NA	Brain	122.6
388.8	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	95.6
NA	Crop	106
159	Midgut	139.7
187.4	Hindgut	100.8
264.8	Malpighian Tubules	139.1
206.4	Fat Body	163.5
454.1	Salivary Gland	117.3
NA	Heart	139.025
153.45	Trachea	NA
NA	VirginFemale Spermatheca	129.3
NA	InseminatedFemale Spermatheca	118.4
NA	Ovary	364.2
NA	Testis	156.6
NA	Male Accessory Gland	224
302.025	Carcass	141.6

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_02

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0035402

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG12082-RA

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for CG12082

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal | pupal stage, with Scer\GAL4^pnr-MD237

CG12082^GD6741

Phenotype manifest in

Allele

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of CG12082	Class	Mutagen	Stocks	Known lesion
CG12082^EY20760		P-element activity	1	--
CG12082^EY23569		P-element activity	1	--

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG12082	Class	Mutagen	Stocks	Known lesion
CG12082^GD6741		in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG12082^JF02163		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD6741}

P{TRiP.JF02163}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EPgy2}CG12082^EY20760

P{EPgy2}CG12082^EY23569

Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 5 terms )

Molecular Function

CV term

Evidence

References

omega peptidase activity

inferred from electronic annotation with InterPro:IPR016652

(FlyBase Curators et al., 2004-)

ubiquitin thiolesterase activity

inferred from electronic annotation with InterPro:IPR001394, InterPro:IPR018200

(FlyBase Curators et al., 2004-)

traceable author statement

(MEROPS Project Members, 1996-)

zinc ion binding

inferred from electronic annotation with InterPro:IPR001607

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

protein deubiquitination

traceable author statement

(MEROPS Project Members, 1996-)

ubiquitin-dependent protein catabolic process

inferred from electronic annotation with InterPro:IPR001394, InterPro:IPR018200

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG12082 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

63873

DPiM - DPiM, Drosophila Protein interaction Map

•

FBgn0035402

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0035402

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

38375

Orthologs

Genome-wide drosophilid orthologs

Dana\GF10220

Dere\GG14479

Dgri\GH15672

Dmoj\GI12716

Dper\GL20751

Dpse\GA11383

Dsec\GM14081

Dsim\GD13355

Dvir\GJ12705

Dwil\GK18032

Dyak\GE21667

Curated drosophilid orthologs

Dpse\GA11383

Linkouts

InParanoid A subset of ortholog calls from InParanoid.

•

AAEL001112-PA
Aedes aegypti (mosquito)
AGAP012248-PA
Anopheles gambiae (mosquito)
XP_624702.1
Apis mellifera (honey bee)
XP_001952484.1
Acyrthosiphon pisum (pea aphid)
At3g20630.1
Arabidopsis thaliana (wall cress)
16102
Batrachochytrium dendrobatidis (chytrid fungus)
284824
Branchiostoma floridae (lancelet)
XP_001902802.1
Brugia malayi (roundworm nematode)
BGIBMGA009941-PA
Bombyx mori (silk worm)
ENSBTAP00000026356
Bos taurus (bovine)
CAL0005412
Candida albicans (a form of yeast)
CBP35748
Caenorhabditis briggsae (nematode)
CE30696
Caenorhabditis elegans (worm)
ENSCAFP00000021591
Canis familiaris (dog)
CAGL0H10186g
Candida glabrata (haploid yeast)
Chro.60521
Cryptosporidium hominis (obligate parasite)
ENSCINP00000014360
Ciona intestinalis (sea squirt)
JA10402
Caenorhabditis japonica (nematode)
CMT098C
Cyanidioschyzon merolae (red alga)
cn06206
Cryptococcus neoformans (yeast-like fungus)
cgd6_4550
Cryptosporidium parvum (protozoan parasite)
CPIJ005706
Culex pipens (mosquito)
ENSCPOP00000011099
Cavia porcellus (guinea pig)
111890
Chlamidomonas reinhardtii (green alga)
RP39200
Caenorhabditis remanei (nematode)
ENSCSAVP00000018670
Ciona savignyi (sedentary tunicate)
182887
Capitella spl (polychaete worm)
DDB0231492
Dictyostelium discoideum (amoeba)
DEHA2G08844g
Debaryomyces Hansenii (yeast)
215987
Daphnia pulex (daphnia)
ENSDARP00000036699
Danio rerio (zebra fish)
ENSECAP00000012739
Equus caballus (horse)
XP_656454
Entamoeba histolytica (anaerobic protozoan)
ENSGACP00000013007
Gymnopilus aculeatus (mushroom)
ENSGALP00000023395
Gallus gallus (chicken)
GL50803_102710
Giardia lamblia (flagellated protozoan)
105332
Hypsipyla robusta (cedar shoot borer)
ENSP00000229268
Homo sapiens (human)
KLLA0F18700g
Kluyveromyces lactis (yeast)
238331
Lottia gigantea (owl limpet)
LmjF29.2300
Leishmania major (virus)
27958
Monocosta brevicollis (choanoflagellate)
ENSMODP00000022630
Monodelphis domestica (gray opossum)
ENSMMUP00000006871
Macaca mulatta (rhesus monkey)
ENSMUSP00000041299
Mus musculus (house mouse)
78936
Nematostella vectensis (starlet anemone)
XP_001606298.1
Nasonia vitripennis (wasp)
ENSORLP00000015974
Oryzias latipes (japanese killifish)
LOC_Os01g08200.1
Oryza sativa (asian rice)
8390
Ostreococcus tauri (green alga)
PFD0655c
Plasmodium falciparum (protozoal parasite)
PHUM004499-PA
Pediculus humanus (human body louse)
155889
Physcomitrella patens (moss)
ENSPPYP00000004792
Pongo pygmaeus (orangutan)
77563
Phytophthora ramorum (sudden oak death pathogen)
108254
Phytophthora sojae (root rot pathogen)
232121
Populus trichocarpa (black cottonwood)
ENSPTRP00000050509
Pan troglodytes (chimpanzee)
PVX_089655
Plasmodium vivax (protozoal parasite)
ENSRNOP00000020785
Rattus norvegicus (norway rat)
4804927
Sorghum bicolor (sorghum)
YBR058C
Saccharomyces cerevisiae (budding yeast)
Smp_069960
Schistosoma mansoni (trematode parasite)
SPBC6B1.06c
Schizosaccharomyces pombe (fission yeast)
XP_796964.2
Strongylocentrotus purpuratus (purple sea urchin)
50430
Trichoplax adhaerens (metazoa)
TA21275
Theileria annulata (apicomplexan parasite)
XP_967156.1
Tribolium castaneum (red flour beetle)
Tc00.1047053508153.120
Trypanosoma cruzi (parasitic trypanosome)
ENSTNIP00000010846
Tetraodon nigroviridis (green spotted pufferfish)
TP01_0316
Theileria parva (parasitic protozoan)
269076
Thalassiosira pseudonana (marine diatom)
ENSTRUP00000026413
Takifugu rubripes (pufferfish Takifugu)
3714.m00007
Tetrahymena thermophila (ciliate protozoa)
81246.m00094
Trichomonas vaginalis (parasitic flagellated protozoan)
ENSXETP00000051604
Xenopus tropicalis (frog)
YALI0B17072g
Yarrowia lipolytica (nonconventional yeast)

OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.

Stocks & Reagents

Stocks Listed in FlyBase ( 5 )

Bloomington

31886

y¹ v¹; P{TRiP.JF02163}attP2

22644

y¹ w^67c23; P{EPgy2}CG12082^EY23569

22426

y¹ w^67c23; P{EPgy2}CG12082^EY20760/TM3, Sb¹ Ser¹

VDRC

v17567

w¹¹¹⁸; P{GD6741}v17567

v17568

w¹¹¹⁸; P{GD6741}v17568

Genomic Clones ( 1 )

BACR48E19

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 31 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

RE70722

Other clones

DPiM_RE70722

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0035402

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

38375

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_139516

RefSeq (Proteins)

•

NP_647773

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

38375

UniProtKB/TrEMBL

•

Q9VZU7

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ubiquitin-associated/translation elongation factor EF1B, N-terminal (IPR000449)

Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (IPR001394)

Zinc finger, UBP-type (IPR001607)

UBA-like (IPR009060)

Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (IPR018200)

Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940)

Ubiquitinyl hydrolase (IPR016652)

Zinc finger, RING/FYVE/PHD-type (IPR013083)

Linkouts

BioGRID - A database of protein and genetic interactions

•

63873

DPiM - DPiM, Drosophila Protein interaction Map

•

FBgn0035402

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0035402

DRSC - Results from RNAi screens.

•

FBgn0035402

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0035402

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG12082-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0035402

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

38375

InParanoid A subset of ortholog calls from InParanoid.

•

AAEL001112-PA
Aedes aegypti (mosquito)
AGAP012248-PA
Anopheles gambiae (mosquito)
XP_624702.1
Apis mellifera (honey bee)
XP_001952484.1
Acyrthosiphon pisum (pea aphid)
At3g20630.1
Arabidopsis thaliana (wall cress)
16102
Batrachochytrium dendrobatidis (chytrid fungus)
284824
Branchiostoma floridae (lancelet)
XP_001902802.1
Brugia malayi (roundworm nematode)
BGIBMGA009941-PA
Bombyx mori (silk worm)
ENSBTAP00000026356
Bos taurus (bovine)
CAL0005412
Candida albicans (a form of yeast)
CBP35748
Caenorhabditis briggsae (nematode)
CE30696
Caenorhabditis elegans (worm)
ENSCAFP00000021591
Canis familiaris (dog)
CAGL0H10186g
Candida glabrata (haploid yeast)
Chro.60521
Cryptosporidium hominis (obligate parasite)
ENSCINP00000014360
Ciona intestinalis (sea squirt)
JA10402
Caenorhabditis japonica (nematode)
CMT098C
Cyanidioschyzon merolae (red alga)
cn06206
Cryptococcus neoformans (yeast-like fungus)
cgd6_4550
Cryptosporidium parvum (protozoan parasite)
CPIJ005706
Culex pipens (mosquito)
ENSCPOP00000011099
Cavia porcellus (guinea pig)
111890
Chlamidomonas reinhardtii (green alga)
RP39200
Caenorhabditis remanei (nematode)
ENSCSAVP00000018670
Ciona savignyi (sedentary tunicate)
182887
Capitella spl (polychaete worm)
DDB0231492
Dictyostelium discoideum (amoeba)
DEHA2G08844g
Debaryomyces Hansenii (yeast)
215987
Daphnia pulex (daphnia)
ENSDARP00000036699
Danio rerio (zebra fish)
ENSECAP00000012739
Equus caballus (horse)
XP_656454
Entamoeba histolytica (anaerobic protozoan)
ENSGACP00000013007
Gymnopilus aculeatus (mushroom)
ENSGALP00000023395
Gallus gallus (chicken)
GL50803_102710
Giardia lamblia (flagellated protozoan)
105332
Hypsipyla robusta (cedar shoot borer)
ENSP00000229268
Homo sapiens (human)
KLLA0F18700g
Kluyveromyces lactis (yeast)
238331
Lottia gigantea (owl limpet)
LmjF29.2300
Leishmania major (virus)
27958
Monocosta brevicollis (choanoflagellate)
ENSMODP00000022630
Monodelphis domestica (gray opossum)
ENSMMUP00000006871
Macaca mulatta (rhesus monkey)
ENSMUSP00000041299
Mus musculus (house mouse)
78936
Nematostella vectensis (starlet anemone)
XP_001606298.1
Nasonia vitripennis (wasp)
ENSORLP00000015974
Oryzias latipes (japanese killifish)
LOC_Os01g08200.1
Oryza sativa (asian rice)
8390
Ostreococcus tauri (green alga)
PFD0655c
Plasmodium falciparum (protozoal parasite)
PHUM004499-PA
Pediculus humanus (human body louse)
155889
Physcomitrella patens (moss)
ENSPPYP00000004792
Pongo pygmaeus (orangutan)
77563
Phytophthora ramorum (sudden oak death pathogen)
108254
Phytophthora sojae (root rot pathogen)
232121
Populus trichocarpa (black cottonwood)
ENSPTRP00000050509
Pan troglodytes (chimpanzee)
PVX_089655
Plasmodium vivax (protozoal parasite)
ENSRNOP00000020785
Rattus norvegicus (norway rat)
4804927
Sorghum bicolor (sorghum)
YBR058C
Saccharomyces cerevisiae (budding yeast)
Smp_069960
Schistosoma mansoni (trematode parasite)
SPBC6B1.06c
Schizosaccharomyces pombe (fission yeast)
XP_796964.2
Strongylocentrotus purpuratus (purple sea urchin)
50430
Trichoplax adhaerens (metazoa)
TA21275
Theileria annulata (apicomplexan parasite)
XP_967156.1
Tribolium castaneum (red flour beetle)
Tc00.1047053508153.120
Trypanosoma cruzi (parasitic trypanosome)
ENSTNIP00000010846
Tetraodon nigroviridis (green spotted pufferfish)
TP01_0316
Theileria parva (parasitic protozoan)
269076
Thalassiosira pseudonana (marine diatom)
ENSTRUP00000026413
Takifugu rubripes (pufferfish Takifugu)
3714.m00007
Tetrahymena thermophila (ciliate protozoa)
81246.m00094
Trichomonas vaginalis (parasitic flagellated protozoan)
ENSXETP00000051604
Xenopus tropicalis (frog)
YALI0B17072g
Yarrowia lipolytica (nonconventional yeast)

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

38375

modMine - Data generated by the modENCODE project.

•

FBgn0035402

OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG12082

(Sepp et al., 2008, Kwong et al., 2008, Perkins et al., 2009, Zhang et al., 2008, Wasbrough et al., 2010, Franco et al., 2011)

Name Synonym

Secondary FlyBase IDs

References ( 19 )

Research paper

Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188: A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919]
Kwong et al., 2008, PLoS Genet. 4(9): e1000178: Stability and dynamics of polycomb target sites in Drosophila development. [FBrf0205674]
Sepp et al., 2008, PLoS Genet. 4(7): e1000111: Identification of neural outgrowth genes using genome-wide RNAi. [FBrf0205132]
Zhang et al., 2008, BMC Bioinformatics 9: 129: Term-tissue specific models for prediction of gene ontology biological processes using transcriptional profiles of aging in drosophila melanogaster. [FBrf0205117]
Chen and Fischer, 2000, Genetics 156(4): 1829--1836: In vivo structure/function analysis of the Drosophila fat facets deubiquitinating enzyme gene. [FBrf0131273]

Supplementary material

The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Wasbrough et al., 2010, J. Proteomics 73(11):: Supplemental Table 1. Mass spectrometry data. [FBrf0213252]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Perkins et al., 2009, Update to TRiP stock collection.: Update to TRiP stock collection. [FBrf0208864]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
Bellen, 2006.8.3, MBBatch686_2.xml: MBBatch686_2.xml [FBrf0191805]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]

Computer file

BDGP Project Members, 2000-, Berkeley Drosophila Genome Project.: Berkeley Drosophila Genome Project. [FBrf0125078]
MEROPS Project Members, 1996-, MEROPS.: MEROPS. [FBrf0128212]

Automatic genome annotation

FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126705]

Curated genome annotation

Zhu, 1999.11, [Annotations performed at the Celera Jamboreee.]: [Annotations performed at the Celera Jamboreee.] [FBrf0126704]