a component of the striatin-interacting phosphatase and kinase (STRIPAK) complex that regulates axon elongation, cytoskeletal stability, and cell signaling - required to ensure the proper development of synaptic boutons at the Drosophila neuromuscular junction - a molecularplatform for the early endosome organization that has important roles in neuronal morphogenesis - negatively regulates the Hippo and clock pathways
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Strip using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Strip in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Strip is required for normal axon elongation during morphogenesis of the olfactory projection neurons. Together with Gl it is involved in clustering of early endosomes prior to their fusion to form mature early endosomes. It appears to be involved in spri-mediated Rab5 activation by stabilising spri protein. It thus acts as a molecular linker between retrograde transport and Rab5 activity in early endosome organisation.