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Gene Dmel\CG12012

General Information
Symbol	Dmel\CG12012	Species	D. melanogaster
Name		Annotation symbol	CG12012
Feature type	protein_coding_gene	FlyBase ID	FBgn0035444
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	63D2-63D2	Sequence location	3L:3,376,757..3,377,687 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG12012 (FBgn0035444). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Brain protein I3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult heart, larval fat body, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634135_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG12012. Gene sequence location is 3L:3376757..3377687.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN29901 HFA08220
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63D2-63D2   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG12012 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG12012-RA FBtr0073076  NM_139556   880   122 CG12012-RB FBtr0300749  NM_001169868   902   81
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG12012-PA   FBpp0072938   13.0   122   4.97     NP_647813   AAF47770 CG12012-PB   FBpp0289973   8.7   81   5.65     NP_001163339   ACZ94611
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Brain protein I3 (IPR019317)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47770   AE014296 ACZ94611   BP541145   BP542450   BP555740   BT025823   BT088924   CO154558   CO155901   CO192731   CO271090   CO304543   CO314192   CO318479   CO342697   EC088263   EC200137   EC220237   EC237351   EC238825   EC253608   EC261923   EC266620   EL873350   ES690775
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VZP9 Q1ECB1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035444    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035444 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035444 expression level Developmental Stage   Expression Level embryo 00-02hr    2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    2267 larva L3 puffstage 7-9    3235 white prepupae new    3236 white prepupae 12hr    3768 white prepupae 24hr    1983 pupae 2d postWPP    1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day    1501 adult male 05day    1403 adult male 30day    1410 adult female 01day    1510 adult female 05day    1681 adult female 30day    1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2194) embryo 02-04hr  (863) embryo 04-06hr  (790) embryo 06-08hr  (854) embryo 08-10hr  (929) embryo 10-12hr  (1130) embryo 12-14hr  (1074) embryo 14-16hr  (959) embryo 16-18hr  (1025) embryo 18-20hr  (725) embryo 20-22hr  (361) embryo 22-24hr  (448) larva L1  (464) larva L2  (610) larva L3 12hr old  (572) larva L3 puffstage 1-2  (1641) larva L3 puffstage 3-6  (2267) larva L3 puffstage 7-9  (3235) white prepupae new  (3236) white prepupae 12hr  (3768) white prepupae 24hr  (1983) pupae 2d postWPP  (1862) pupae 3d postWPP  (1254) pupae 4d postWPP  (953) adult male 01day  (1501) adult male 05day  (1403) adult male 30day  (1410) adult female 01day  (1510) adult female 05day  (1681) adult female 30day  (1871) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2194) embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2  (1641) larva L3 puffstage 3-6  (2267) larva L3 puffstage 7-9  (3235) white prepupae new  (3236) white prepupae 12hr  (3768) white prepupae 24hr  (1983) pupae 2d postWPP  (1862) pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day  1501 adult male 05day  1403 adult male 30day  1410 adult female 01day  (1510) adult female 05day  (1681) adult female 30day  (1871) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    2267 larva L3 puffstage 7-9    3235 white prepupae new    3236 white prepupae 12hr    3768 white prepupae 24hr    1983 pupae 2d postWPP    1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day    1501 adult male 05day    1403 adult male 30day    1410 adult female 01day    1510 adult female 05day    1681 adult female 30day    1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    2267 larva L3 puffstage 7-9    3235 white prepupae new    3236 white prepupae 12hr    3768 white prepupae 24hr    1983 pupae 2d postWPP    1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day    1501 adult male 05day    1403 adult male 30day    1410 adult female 01day    1510 adult female 05day    1681 adult female 30day    1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035444 expression level Developmental Stage   Expression Level embryo 00-02hr    2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    2267 larva L3 puffstage 7-9    3235 white prepupae new    3236 white prepupae 12hr    3768 white prepupae 24hr    1983 pupae 2d postWPP    1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day    1501 adult male 05day    1403 adult male 30day    1410 adult female 01day    1510 adult female 05day    1681 adult female 30day    1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2194) embryo 02-04hr  (863) embryo 04-06hr  (790) embryo 06-08hr  (854) embryo 08-10hr  (929) embryo 10-12hr  (1130) embryo 12-14hr  (1074) embryo 14-16hr  (959) embryo 16-18hr  (1025) embryo 18-20hr  (725) embryo 20-22hr  (361) embryo 22-24hr  (448) larva L1  (464) larva L2  (610) larva L3 12hr old  (572) larva L3 puffstage 1-2  (1641) larva L3 puffstage 3-6  (2267) larva L3 puffstage 7-9  (3235) white prepupae new  (3236) white prepupae 12hr  (3768) white prepupae 24hr  (1983) pupae 2d postWPP  (1862) pupae 3d postWPP  (1254) pupae 4d postWPP  (953) adult male 01day  (1501) adult male 05day  (1403) adult male 30day  (1410) adult female 01day  (1510) adult female 05day  (1681) adult female 30day  (1871) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2  1641 larva L3 puffstage 3-6  2267 larva L3 puffstage 7-9  (3235) white prepupae new  (3236) white prepupae 12hr  (3768) white prepupae 24hr  1983 pupae 2d postWPP  1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day  1501 adult male 05day  1403 adult male 30day  1410 adult female 01day  1510 adult female 05day  1681 adult female 30day  1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    2267 larva L3 puffstage 7-9    3235 white prepupae new    3236 white prepupae 12hr    3768 white prepupae 24hr    1983 pupae 2d postWPP    1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day    1501 adult male 05day    1403 adult male 30day    1410 adult female 01day    1510 adult female 05day    1681 adult female 30day    1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2194 embryo 02-04hr    863 embryo 04-06hr    790 embryo 06-08hr    854 embryo 08-10hr    929 embryo 10-12hr    1130 embryo 12-14hr    1074 embryo 14-16hr    959 embryo 16-18hr    1025 embryo 18-20hr    725 embryo 20-22hr    361 embryo 22-24hr    448 larva L1    464 larva L2    610 larva L3 12hr old    572 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    2267 larva L3 puffstage 7-9    3235 white prepupae new    3236 white prepupae 12hr    3768 white prepupae 24hr    1983 pupae 2d postWPP    1862 pupae 3d postWPP    1254 pupae 4d postWPP    953 adult male 01day    1501 adult male 05day    1403 adult male 30day    1410 adult female 01day    1510 adult female 05day    1681 adult female 30day    1871 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035444    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035444 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult heart, larval fat body, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035444 expression level Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body    569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland    536.5 Adult Heart    554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body  (569.9) Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland  536.5 Adult Heart  (554.825) Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body    569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland    536.5 Adult Heart    554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body    569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland    536.5 Adult Heart    554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035444 expression level Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body    569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland    536.5 Adult Heart    554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body  569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland  536.5 Adult Heart  554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body    569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland    536.5 Adult Heart    554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.6 Larval Midgut    255.1 Larval Hindgut    210.5 Larval Malpighian Tubules    408 Larval Fat Body    569.9 Larval Salivary Gland    282.5 Larval Trachea    189.15 Larval Carcass    106.175 Adult Head    177.8 Adult Eye    207.15 Adult Brain    158.7 Adult Thoracic-Abdominal Ganglion    157.7 Adult Crop    260.5 Adult Midgut    224.5 Adult Hindgut    282.7 Adult Malpighian Tubules    92.5 Adult Fat Body    208.3 Adult Salivary Gland    536.5 Adult Heart    554.825 Adult VirginFemale Spermatheca    178.8 Adult InseminatedFemale Spermatheca    174.5 Adult Ovary    174.3 Adult Testis    37.9 Adult Male Accessory Gland    143.6 Adult Carcass    206.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    177.8   NA  Eye    207.15   NA  Brain    158.7   98.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    157.7   NA  Crop    260.5   255.1  Midgut    224.5   210.5  Hindgut    282.7   408  Malpighian Tubules    92.5   569.9  Fat Body    208.3   282.5  Salivary Gland    536.5   NA  Heart    554.825   189.15  Trachea    NA   NA  VirginFemale Spermatheca    178.8   NA  InseminatedFemale Spermatheca    174.5   NA  Ovary    174.3   NA  Testis    37.9   NA  Male Accessory Gland    143.6   106.175  Carcass    206.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035444 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12012-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG12012GD444 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG12012 Class Mutagen Stocks Known lesion CG12012EY23374 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG12012 Class Mutagen Stocks Known lesion CG12012GD444 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG12012HMS00982 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG12012KK109901 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6093 (Ryder, 2004.4.26) Df(3L)Exel6094 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD444} NA P{KK109901} NA P{TRiP.HMS00982} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG12012EY23374 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG12012 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63917 DroID - A comprehensive database of gene and protein interactions. • FBgn0035444 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38422
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24209 Dere\GG15138 Dgri\GH23325 Dmoj\GI12379 Dper\GL13248 Dpse\GA11335 Dsec\GM14571 Dsim\GD13762 Dvir\GJ12269 Dwil\GK20512 Dyak\GE21363
Curated drosophilid orthologs	Dpse\GA11335
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007537-PA Aedes aegypti (mosquito) AAEL015493-PA Aedes aegypti (mosquito) AGAP008905-PA Anopheles gambiae (mosquito) XP_392884.1 Apis mellifera (honey bee) 87099 Batrachochytrium dendrobatidis (chytrid fungus) 87997 Branchiostoma floridae (lancelet) 92108 Branchiostoma floridae (lancelet) BGIBMGA012055-PA Bombyx mori (silk worm) ENSCAFP00000022624 Canis familiaris (dog) ENSCINP00000026233 Ciona intestinalis (sea squirt) CPIJ010035 Culex pipens (mosquito) ENSCPOP00000020651 Cavia porcellus (guinea pig) ENSCSAVP00000003751 Ciona savignyi (sedentary tunicate) 229039 Capitella spl (polychaete worm) 310068 Daphnia pulex (daphnia) ENSECAP00000001626 Equus caballus (horse) ENSGALP00000033669 Gallus gallus (chicken) 179222 Hypsipyla robusta (cedar shoot borer) ENSP00000297290 Homo sapiens (human) 110248 Lottia gigantea (owl limpet) ENSMODP00000010372 Monodelphis domestica (gray opossum) ENSMMUP00000017460 Macaca mulatta (rhesus monkey) ENSMUSP00000057263 Mus musculus (house mouse) ENSORLP00000011921 Oryzias latipes (japanese killifish) PHUM010613-PA Pediculus humanus (human body louse) ENSPPYP00000001296 Pongo pygmaeus (orangutan) ENSPPYP00000023452 Pongo pygmaeus (orangutan) ENSRNOP00000001336 Rattus norvegicus (norway rat) XP_784448.1 Strongylocentrotus purpuratus (purple sea urchin) XP_971772.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000699 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024337 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000051839 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17006 NV22811 LH13985 FBgn0238625 FBgn0222509 FBgn0199518 FBgn0185462 FBgn0169492 JGI_V11_310068 JGI_V11_301827 FBgn0071389 FBgn0150854 FBgn0135136 FBgn0130782 FBgn0123581 FBgn0107391 FBgn0101203 CPIJ010035 BGIBMGA012055 GB10988 AGAP008905 AAEL015493 AAEL007537 PHUM519400 GLEAN_00131
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	34015 y1 sc* v1; P{TRiP.HMS00982}attP2 22628 y1 w67c23; P{EPgy2}CG12012EY23374
VDRC	v105505 P{KK109901}VIE-260B v33097 w1118; P{GD444}v33097/TM3
Genomic Clones ( 2 )
	BACR17M19 BACR19M09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 21 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	IP05417
Other clones	IP05517
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	56556 108809 167267 214381.17 523876 525690 CK01.133B.B2 EC34371 EK101937 EK235263 EK245044 EK272317 EN04349 EN06943 EP15345 FGA011A05 FGC013C09 FGM236H05 IP05217
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035444 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38422
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139556 NM_001169868 RefSeq (Proteins) • NP_647813 NP_001163339 DDBJ / EMBL / GenBank • AAF47770 ACZ94611 Entrez Gene - A searchable database of RefSeq genes. • 38422 UniProtKB/TrEMBL • Q1ECB1 Q9VZP9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Brain protein I3 (IPR019317)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63917 DroID - A comprehensive database of gene and protein interactions. • FBgn0035444 DRSC - Results from RNAi screens. • FBgn0035444 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035444 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12012-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035444 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38422 InParanoid A subset of ortholog calls from InParanoid. • AAEL007537-PA Aedes aegypti (mosquito) AAEL015493-PA Aedes aegypti (mosquito) AGAP008905-PA Anopheles gambiae (mosquito) XP_392884.1 Apis mellifera (honey bee) 87099 Batrachochytrium dendrobatidis (chytrid fungus) 87997 Branchiostoma floridae (lancelet) 92108 Branchiostoma floridae (lancelet) BGIBMGA012055-PA Bombyx mori (silk worm) ENSCAFP00000022624 Canis familiaris (dog) ENSCINP00000026233 Ciona intestinalis (sea squirt) CPIJ010035 Culex pipens (mosquito) ENSCPOP00000020651 Cavia porcellus (guinea pig) ENSCSAVP00000003751 Ciona savignyi (sedentary tunicate) 229039 Capitella spl (polychaete worm) 310068 Daphnia pulex (daphnia) ENSECAP00000001626 Equus caballus (horse) ENSGALP00000033669 Gallus gallus (chicken) 179222 Hypsipyla robusta (cedar shoot borer) ENSP00000297290 Homo sapiens (human) 110248 Lottia gigantea (owl limpet) ENSMODP00000010372 Monodelphis domestica (gray opossum) ENSMMUP00000017460 Macaca mulatta (rhesus monkey) ENSMUSP00000057263 Mus musculus (house mouse) ENSORLP00000011921 Oryzias latipes (japanese killifish) PHUM010613-PA Pediculus humanus (human body louse) ENSPPYP00000001296 Pongo pygmaeus (orangutan) ENSPPYP00000023452 Pongo pygmaeus (orangutan) ENSRNOP00000001336 Rattus norvegicus (norway rat) XP_784448.1 Strongylocentrotus purpuratus (purple sea urchin) XP_971772.1 Tribolium castaneum (red flour beetle) ENSTNIP00000000699 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000024337 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000051839 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38422 modMine - Data generated by the modENCODE project. • FBgn0035444 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17006 NV22811 LH13985 FBgn0238625 FBgn0222509 FBgn0199518 FBgn0185462 FBgn0169492 JGI_V11_310068 JGI_V11_301827 FBgn0071389 FBgn0150854 FBgn0135136 FBgn0130782 FBgn0123581 FBgn0107391 FBgn0101203 CPIJ010035 BGIBMGA012055 GB10988 AGAP008905 AAEL015493 AAEL007537 PHUM519400 GLEAN_00131
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG12012 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1)
Name Synonym
Secondary FlyBase IDs
References ( 11 )
Research paper	Fujii and Amrein, 2002, EMBO J. 21(20): 5353--5363 Genes expressed in the Drosophila head reveal a role for fat cells in sex-specific physiology. [FBrf0151956]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Robertson, 2001.7.7, Third set of annotation suggestions from bee ESTs. Third set of annotation suggestions from bee ESTs. [FBrf0138600]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]