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Gene Dmel\Sc2

General Information
Symbol	Dmel\Sc2	Species	D. melanogaster
Name	Sc2	Annotation symbol	CG10849
Feature type	protein_coding_gene	FlyBase ID	FBgn0035471
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	l(3)05634, dSc2, l(3)63Eb
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	63F5-63F6	Sequence location	3L:3,903,511..3,905,033 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sc2 is referred to in FlyBase by the symbol Dmel\Sc2 (CG10849, FBgn0035471). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: oxidoreductase activity, acting on the CH-CH group of donors. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: lipid metabolic process. 15 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal; Ubiquitin supergroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-18 embryonic stages, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, adult midgut, adult hindgut, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, adult salivary gland, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1634542_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sc2. Gene sequence location is 3L:3903511..3905033.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA08162 BKN22607
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 63F5-63F6   Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
Experimentally Determined Cytological Location
Cytogenetic map Notes References 63F5-63F6   (determined by in situ hybridisation)   (Spradling et al., 1999) 63F5-63F6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sc2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sc2-RA FBtr0073159  NM_139579   1084   302
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sc2-PA   FBpp0073017   34.2   302   10.04     NP_647836   AAF47807
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal (IPR001104) Ubiquitin supergroup (IPR019955)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47807   AI107773   AI134448   AI257819   AI403387   AI404938   AI405453   AI542826   AI945897   AW944585   AY061621 AAL29169   BE975564   BF505375   BI166034   BI169934   BI172726   BI232300   BI233247   BI236470   BI240677   BI354103   BI365140   BI367606   BI373489   BI632853   BP557379   BT050505   CO157018   CO194565   CO266438   CO279937   CO297778   CO297895   CO312385   CO313687   CO319400   CO320534   CO321346   CO338948   EC085581   EC088183   EC204423   EC204735   EC210401   EC222839   EC225257   EC251657   EC266730   EL882720   EV581023   EV597510   G01167   GH943717   GH943799   GH946274   GH947011   GH951423   GH952100   GH952596   GH954558   GH955334   GH955751   GH958583   GH964682   GH965537   GH970626   GH970984   GH979907   GH983566
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q95R45 Q9VZL3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035471    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035471 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 12-18 embryonic stages, during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035471 expression level Developmental Stage   Expression Level embryo 00-02hr    8029 embryo 02-04hr    7244 embryo 04-06hr    4591 embryo 06-08hr    2059 embryo 08-10hr    2788 embryo 10-12hr    4951 embryo 12-14hr    5902 embryo 14-16hr    10501 embryo 16-18hr    8382 embryo 18-20hr    4014 embryo 20-22hr    2138 embryo 22-24hr    2827 larva L1    4859 larva L2    12415 larva L3 12hr old    7262 larva L3 puffstage 1-2    4178 larva L3 puffstage 3-6    4117 larva L3 puffstage 7-9    4732 white prepupae new    4995 white prepupae 12hr    5112 white prepupae 24hr    5744 pupae 2d postWPP    5338 pupae 3d postWPP    5599 pupae 4d postWPP    3584 adult male 01day    10579 adult male 05day    14736 adult male 30day    13800 adult female 01day    7369 adult female 05day    8256 adult female 30day    9525 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8029) embryo 02-04hr  (7244) embryo 04-06hr  (4591) embryo 06-08hr  (2059) embryo 08-10hr  (2788) embryo 10-12hr  (4951) embryo 12-14hr  (5902) embryo 14-16hr  (10501) embryo 16-18hr  (8382) embryo 18-20hr  (4014) embryo 20-22hr  (2138) embryo 22-24hr  (2827) larva L1  (4859) larva L2  (12415) larva L3 12hr old  (7262) larva L3 puffstage 1-2  (4178) larva L3 puffstage 3-6  (4117) larva L3 puffstage 7-9  (4732) white prepupae new  (4995) white prepupae 12hr  (5112) white prepupae 24hr  (5744) pupae 2d postWPP  (5338) pupae 3d postWPP  (5599) pupae 4d postWPP  (3584) adult male 01day  (10579) adult male 05day  (14736) adult male 30day  (13800) adult female 01day  (7369) adult female 05day  (8256) adult female 30day  (9525) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8029) embryo 02-04hr  (7244) embryo 04-06hr  (4591) embryo 06-08hr  (2059) embryo 08-10hr  (2788) embryo 10-12hr  (4951) embryo 12-14hr  (5902) embryo 14-16hr  (10501) embryo 16-18hr  (8382) embryo 18-20hr  (4014) embryo 20-22hr  (2138) embryo 22-24hr  (2827) larva L1  (4859) larva L2  (12415) larva L3 12hr old  (7262) larva L3 puffstage 1-2  (4178) larva L3 puffstage 3-6  (4117) larva L3 puffstage 7-9  (4732) white prepupae new  (4995) white prepupae 12hr  (5112) white prepupae 24hr  (5744) pupae 2d postWPP  (5338) pupae 3d postWPP  (5599) pupae 4d postWPP  (3584) adult male 01day  (10579) adult male 05day  (14736) adult male 30day  (13800) adult female 01day  (7369) adult female 05day  (8256) adult female 30day  (9525) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8029 embryo 02-04hr    7244 embryo 04-06hr    4591 embryo 06-08hr    2059 embryo 08-10hr    2788 embryo 10-12hr    4951 embryo 12-14hr    5902 embryo 14-16hr  10501 embryo 16-18hr    8382 embryo 18-20hr    4014 embryo 20-22hr    2138 embryo 22-24hr    2827 larva L1    4859 larva L2  (12415) larva L3 12hr old    7262 larva L3 puffstage 1-2    4178 larva L3 puffstage 3-6    4117 larva L3 puffstage 7-9    4732 white prepupae new    4995 white prepupae 12hr    5112 white prepupae 24hr    5744 pupae 2d postWPP    5338 pupae 3d postWPP    5599 pupae 4d postWPP    3584 adult male 01day  10579 adult male 05day  (14736) adult male 30day  (13800) adult female 01day    7369 adult female 05day    8256 adult female 30day    9525 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8029 embryo 02-04hr    7244 embryo 04-06hr    4591 embryo 06-08hr    2059 embryo 08-10hr    2788 embryo 10-12hr    4951 embryo 12-14hr    5902 embryo 14-16hr    10501 embryo 16-18hr    8382 embryo 18-20hr    4014 embryo 20-22hr    2138 embryo 22-24hr    2827 larva L1    4859 larva L2    12415 larva L3 12hr old    7262 larva L3 puffstage 1-2    4178 larva L3 puffstage 3-6    4117 larva L3 puffstage 7-9    4732 white prepupae new    4995 white prepupae 12hr    5112 white prepupae 24hr    5744 pupae 2d postWPP    5338 pupae 3d postWPP    5599 pupae 4d postWPP    3584 adult male 01day    10579 adult male 05day    14736 adult male 30day    13800 adult female 01day    7369 adult female 05day    8256 adult female 30day    9525 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035471 expression level Developmental Stage   Expression Level embryo 00-02hr    8029 embryo 02-04hr    7244 embryo 04-06hr    4591 embryo 06-08hr    2059 embryo 08-10hr    2788 embryo 10-12hr    4951 embryo 12-14hr    5902 embryo 14-16hr    10501 embryo 16-18hr    8382 embryo 18-20hr    4014 embryo 20-22hr    2138 embryo 22-24hr    2827 larva L1    4859 larva L2    12415 larva L3 12hr old    7262 larva L3 puffstage 1-2    4178 larva L3 puffstage 3-6    4117 larva L3 puffstage 7-9    4732 white prepupae new    4995 white prepupae 12hr    5112 white prepupae 24hr    5744 pupae 2d postWPP    5338 pupae 3d postWPP    5599 pupae 4d postWPP    3584 adult male 01day    10579 adult male 05day    14736 adult male 30day    13800 adult female 01day    7369 adult female 05day    8256 adult female 30day    9525 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8029) embryo 02-04hr  (7244) embryo 04-06hr  (4591) embryo 06-08hr  (2059) embryo 08-10hr  (2788) embryo 10-12hr  (4951) embryo 12-14hr  (5902) embryo 14-16hr  (10501) embryo 16-18hr  (8382) embryo 18-20hr  (4014) embryo 20-22hr  (2138) embryo 22-24hr  (2827) larva L1  (4859) larva L2  (12415) larva L3 12hr old  (7262) larva L3 puffstage 1-2  (4178) larva L3 puffstage 3-6  (4117) larva L3 puffstage 7-9  (4732) white prepupae new  (4995) white prepupae 12hr  (5112) white prepupae 24hr  (5744) pupae 2d postWPP  (5338) pupae 3d postWPP  (5599) pupae 4d postWPP  (3584) adult male 01day  (10579) adult male 05day  (14736) adult male 30day  (13800) adult female 01day  (7369) adult female 05day  (8256) adult female 30day  (9525) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8029) embryo 02-04hr  (7244) embryo 04-06hr  (4591) embryo 06-08hr  2059 embryo 08-10hr  (2788) embryo 10-12hr  (4951) embryo 12-14hr  (5902) embryo 14-16hr  (10501) embryo 16-18hr  (8382) embryo 18-20hr  (4014) embryo 20-22hr  2138 embryo 22-24hr  (2827) larva L1  (4859) larva L2  (12415) larva L3 12hr old  (7262) larva L3 puffstage 1-2  (4178) larva L3 puffstage 3-6  (4117) larva L3 puffstage 7-9  (4732) white prepupae new  (4995) white prepupae 12hr  (5112) white prepupae 24hr  (5744) pupae 2d postWPP  (5338) pupae 3d postWPP  (5599) pupae 4d postWPP  (3584) adult male 01day  (10579) adult male 05day  (14736) adult male 30day  (13800) adult female 01day  (7369) adult female 05day  (8256) adult female 30day  (9525) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8029 embryo 02-04hr    7244 embryo 04-06hr    4591 embryo 06-08hr    2059 embryo 08-10hr    2788 embryo 10-12hr    4951 embryo 12-14hr    5902 embryo 14-16hr  10501 embryo 16-18hr    8382 embryo 18-20hr    4014 embryo 20-22hr    2138 embryo 22-24hr    2827 larva L1    4859 larva L2  12415 larva L3 12hr old    7262 larva L3 puffstage 1-2    4178 larva L3 puffstage 3-6    4117 larva L3 puffstage 7-9    4732 white prepupae new    4995 white prepupae 12hr    5112 white prepupae 24hr    5744 pupae 2d postWPP    5338 pupae 3d postWPP    5599 pupae 4d postWPP    3584 adult male 01day  10579 adult male 05day  14736 adult male 30day  13800 adult female 01day    7369 adult female 05day    8256 adult female 30day    9525 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8029 embryo 02-04hr    7244 embryo 04-06hr    4591 embryo 06-08hr    2059 embryo 08-10hr    2788 embryo 10-12hr    4951 embryo 12-14hr    5902 embryo 14-16hr    10501 embryo 16-18hr    8382 embryo 18-20hr    4014 embryo 20-22hr    2138 embryo 22-24hr    2827 larva L1    4859 larva L2    12415 larva L3 12hr old    7262 larva L3 puffstage 1-2    4178 larva L3 puffstage 3-6    4117 larva L3 puffstage 7-9    4732 white prepupae new    4995 white prepupae 12hr    5112 white prepupae 24hr    5744 pupae 2d postWPP    5338 pupae 3d postWPP    5599 pupae 4d postWPP    3584 adult male 01day    10579 adult male 05day    14736 adult male 30day    13800 adult female 01day    7369 adult female 05day    8256 adult female 30day    9525 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035471    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035471 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, adult midgut, adult hindgut, adult heart, adult fat body, larval salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval midgut, larval hindgut, larval/adult Malpighian tubules, larval fat body, adult salivary gland, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035471 expression level Tissue   Expression Level Larval Central Nervous System    706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland    520.6 Larval Trachea    671.725 Larval Carcass    696.975 Adult Head    583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    4075.5 Adult Midgut    800.4 Adult Hindgut    2210.2 Adult Malpighian Tubules    196.4 Adult Fat Body    3895.8 Adult Salivary Gland    445.2 Adult Heart    4273.75 Adult VirginFemale Spermatheca    776.5 Adult InseminatedFemale Spermatheca    664.1 Adult Ovary    579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass    3550.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (706.625) Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland  520.6 Larval Trachea  (671.725) Larval Carcass  (696.975) Adult Head  (583.2) Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop  (4075.5) Adult Midgut  (800.4) Adult Hindgut  (2210.2) Adult Malpighian Tubules    196.4 Adult Fat Body  (3895.8) Adult Salivary Gland    445.2 Adult Heart  (4273.75) Adult VirginFemale Spermatheca  (776.5) Adult InseminatedFemale Spermatheca  (664.1) Adult Ovary  (579.2) Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass  (3550.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland    520.6 Larval Trachea    671.725 Larval Carcass    696.975 Adult Head    583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop  (4075.5) Adult Midgut    800.4 Adult Hindgut  (2210.2) Adult Malpighian Tubules    196.4 Adult Fat Body  (3895.8) Adult Salivary Gland    445.2 Adult Heart  (4273.75) Adult VirginFemale Spermatheca    776.5 Adult InseminatedFemale Spermatheca    664.1 Adult Ovary    579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass  (3550.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland    520.6 Larval Trachea    671.725 Larval Carcass    696.975 Adult Head    583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    4075.5 Adult Midgut    800.4 Adult Hindgut    2210.2 Adult Malpighian Tubules    196.4 Adult Fat Body    3895.8 Adult Salivary Gland    445.2 Adult Heart    4273.75 Adult VirginFemale Spermatheca    776.5 Adult InseminatedFemale Spermatheca    664.1 Adult Ovary    579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass    3550.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035471 expression level Tissue   Expression Level Larval Central Nervous System    706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland    520.6 Larval Trachea    671.725 Larval Carcass    696.975 Adult Head    583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    4075.5 Adult Midgut    800.4 Adult Hindgut    2210.2 Adult Malpighian Tubules    196.4 Adult Fat Body    3895.8 Adult Salivary Gland    445.2 Adult Heart    4273.75 Adult VirginFemale Spermatheca    776.5 Adult InseminatedFemale Spermatheca    664.1 Adult Ovary    579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass    3550.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland  520.6 Larval Trachea  671.725 Larval Carcass  696.975 Adult Head  583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop  (4075.5) Adult Midgut  800.4 Adult Hindgut  (2210.2) Adult Malpighian Tubules    196.4 Adult Fat Body  (3895.8) Adult Salivary Gland    445.2 Adult Heart  (4273.75) Adult VirginFemale Spermatheca  776.5 Adult InseminatedFemale Spermatheca  664.1 Adult Ovary  579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass  (3550.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland    520.6 Larval Trachea    671.725 Larval Carcass    696.975 Adult Head    583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop  (4075.5) Adult Midgut    800.4 Adult Hindgut  (2210.2) Adult Malpighian Tubules    196.4 Adult Fat Body  (3895.8) Adult Salivary Gland    445.2 Adult Heart  (4273.75) Adult VirginFemale Spermatheca    776.5 Adult InseminatedFemale Spermatheca    664.1 Adult Ovary    579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass  (3550.7) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    706.625 Larval Midgut    470.6 Larval Hindgut    415 Larval Malpighian Tubules    297.6 Larval Fat Body    492.3 Larval Salivary Gland    520.6 Larval Trachea    671.725 Larval Carcass    696.975 Adult Head    583.2 Adult Eye    447.55 Adult Brain    351.3 Adult Thoracic-Abdominal Ganglion    457.7 Adult Crop    4075.5 Adult Midgut    800.4 Adult Hindgut    2210.2 Adult Malpighian Tubules    196.4 Adult Fat Body    3895.8 Adult Salivary Gland    445.2 Adult Heart    4273.75 Adult VirginFemale Spermatheca    776.5 Adult InseminatedFemale Spermatheca    664.1 Adult Ovary    579.2 Adult Testis    386.1 Adult Male Accessory Gland    471 Adult Carcass    3550.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    583.2   NA  Eye    447.55   NA  Brain    351.3   706.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    457.7   NA  Crop    4075.5   470.6  Midgut    800.4   415  Hindgut    2210.2   297.6  Malpighian Tubules    196.4   492.3  Fat Body    3895.8   520.6  Salivary Gland    445.2   NA  Heart    4273.75   671.725  Trachea    NA   NA  VirginFemale Spermatheca    776.5   NA  InseminatedFemale Spermatheca    664.1   NA  Ovary    579.2   NA  Testis    386.1   NA  Male Accessory Gland    471   696.975  Carcass    3550.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035471 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10849-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Sc2GD2286 lethal | embryonic stage | recessive Sc2unspecified lethal | larval stage Sc205634 lethal | larval stage (with Df(3L)GN19) Sc205634 Sc2A4 Sc2E15 lethal | pupal stage | recessive Sc21 lethal | recessive Sc210 Sc205634 Sc2A4 Sc2E15 Sc2F9 viable Sc2CB04638 Phenotype manifest in Allele
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Sc2 Class Mutagen Stocks Known lesion Sc21 hypomorphic allele - genetic evidence ethyl methanesulfonate 2 -- Sc205634 P-element activity 1 Yes Sc210 1 Yes Sc2A4 1 -- Sc2CB-6976-3 1 -- Sc2EY02236 1 -- Sc2F9 1 -- Sc2NP3321 1 -- Sc2NP4464 1 -- Sc25-HA-2444 0 -- Sc2CB04638 P-element activity 0 Yes Sc2E15 0 -- Sc2unspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sc2 Class Mutagen Stocks Known lesion Sc2GD2286 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sc2KK102526 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)1227 (Spradling et al., 1999) Df(3L)BSC368 (Christensen et al., 2007.10.29) Df(3L)Exel6098 (Ryder, 2004.4.26) Df(3L)GN19 (Vaskova et al., 2000, Harrison et al., 1995) Df(3L)GN34 (Harrison et al., 1995) Df(3L)HR119 (Wohlwill and Bonner, 1991, BDGP Project Members, 1994-1999) Df(3L)HR277 (Wohlwill and Bonner, 1991) Df(3L)HR298 (Wohlwill and Bonner, 1991, Harrison et al., 1995)
Not disrupted in	Df(3L)C175 (Harrison et al., 1995) Df(3L)GN24 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Spradling et al., 1995) Df(3L)HR218 (Wohlwill and Bonner, 1991) Df(3L)HR232 (Wohlwill and Bonner, 1991) Df(3L)HR370 (Wohlwill and Bonner, 1991) Df(3L)TE1 (Harrison et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2286} NA P{KK102526} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}Sc205634 No insertion of mobile activating element P{EPgy2}Sc2EY02236 NA insertion of enhancer trap binary system P{GawB}Sc2NP3321 No P{GawB}Sc2NP4464 No miscellaneous insertions P{PTT-GB}Sc2CB04638 NA P{RS3}Sc2CB-6976-3 NA P{RS5}Sc25-HA-2444 NA P{UASp-YFP.Rab8.Q67L}Sc210 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
oxidoreductase activity, acting on the CH-CH group of donors inferred from electronic annotation with InterPro:IPR001104 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
lipid metabolic process inferred from electronic annotation with InterPro:IPR001104 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR001104 (FlyBase Curators et al., 2004-) integral to membrane inferred from electronic annotation with InterPro:IPR001104 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sc2 allele Gene References Sc205634 Kr (Carrera et al., 1998, Abrell et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63945 DroID - A comprehensive database of gene and protein interactions. • FBgn0035471 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38457
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24232 Dere\GG15168 Dgri\GH15767 Dmoj\GI12546 Dper\GL16056 Dpse\GA10597 Dsec\GM14597 Dsim\GD13786 Dvir\GJ16064 Dwil\GK16849 Dyak\GE21388
Curated drosophilid orthologs	Dpse\GA10597
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008740-PA Aedes aegypti (mosquito) AGAP010714-PA Anopheles gambiae (mosquito) XP_001120311.1 Apis mellifera (honey bee) XP_001950623.1 Acyrthosiphon pisum (pea aphid) At3g55360.1 Arabidopsis thaliana (wall cress) 12866 Batrachochytrium dendrobatidis (chytrid fungus) 123019 Branchiostoma floridae (lancelet) BGIBMGA003493-PA Bombyx mori (silk worm) ENSBTAP00000050712 Bos taurus (bovine) CAL0003440 Candida albicans (a form of yeast) CN03194 Caenorhabditis brenneri (small nematode) CBP02739 Caenorhabditis briggsae (nematode) CE20509 Caenorhabditis elegans (worm) ENSCAFP00000023972 Canis familiaris (dog) CAGL0K01837g Candida glabrata (haploid yeast) Chro.20132 Cryptosporidium hominis (obligate parasite) ENSCINP00000008647 Ciona intestinalis (sea squirt) JA11518 Caenorhabditis japonica (nematode) CMD146C Cyanidioschyzon merolae (red alga) cn05180 Cryptococcus neoformans (yeast-like fungus) cgd2_1200 Cryptosporidium parvum (protozoan parasite) CPIJ005584 Culex pipens (mosquito) ENSCPOP00000013003 Cavia porcellus (guinea pig) 602 Chlamidomonas reinhardtii (green alga) RP03457 Caenorhabditis remanei (nematode) ENSCSAVP00000018714 Ciona savignyi (sedentary tunicate) 167372 Capitella spl (polychaete worm) DDB0237530 Dictyostelium discoideum (amoeba) DEHA2B00968g Debaryomyces Hansenii (yeast) 199063 Daphnia pulex (daphnia) ENSDARP00000095385 Danio rerio (zebra fish) ENSECAP00000016737 Equus caballus (horse) XP_657257 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024895 Gymnopilus aculeatus (mushroom) ENSGALP00000009263 Gallus gallus (chicken) GL50803_88581 Giardia lamblia (flagellated protozoan) 155722 Hypsipyla robusta (cedar shoot borer) ENSP00000215567 Homo sapiens (human) ISCW002618-PA Ixodes scapularis (deer tick) KLLA0C04367g Kluyveromyces lactis (yeast) 232335 Lottia gigantea (owl limpet) LmjF25.1770 Leishmania major (virus) ENSMODP00000032508 Monodelphis domestica (gray opossum) ENSMMUP00000028466 Macaca mulatta (rhesus monkey) ENSMUSP00000019382 Mus musculus (house mouse) 147144 Nematostella vectensis (starlet anemone) XP_001601952.1 Nasonia vitripennis (wasp) ENSOANP00000006129 Ornithorynchus anatinus (platypus) ENSORLP00000018633 Oryzias latipes (japanese killifish) LOC_Os01g05670.1 Oryza sativa (asian rice) 16084 Ostreococcus tauri (green alga) PHUM003357-PA Pediculus humanus (human body louse) PP14200 Pristionchus pacificus (nematode) 203665 Physcomitrella patens (moss) ENSPPYP00000010812 Pongo pygmaeus (orangutan) 71193 Phytophthora ramorum (sudden oak death pathogen) 720621 Populus trichocarpa (black cottonwood) ENSPTRP00000018079 Pan troglodytes (chimpanzee) PVX_092410 Plasmodium vivax (protozoal parasite) ENSRNOP00000025594 Rattus norvegicus (norway rat) 4751185 Sorghum bicolor (sorghum) YDL015C Saccharomyces cerevisiae (budding yeast) Smp_081820.3 Schistosoma mansoni (trematode parasite) SPBC646.07c Schizosaccharomyces pombe (fission yeast) XP_001176486.1 Strongylocentrotus purpuratus (purple sea urchin) 29423 Trichoplax adhaerens (metazoa) TA18840 Theileria annulata (apicomplexan parasite) XP_971180.1 Tribolium castaneum (red flour beetle) Tc00.1047053457251.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017099 Tetraodon nigroviridis (green spotted pufferfish) TP03_0656 Theileria parva (parasitic protozoan) 33911 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010871 Takifugu rubripes (pufferfish Takifugu) 3713.m00083 Tetrahymena thermophila (ciliate protozoa) 88043.m00118 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000044498 Xenopus tropicalis (frog) YALI0A04983g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11303 LH19085 ISCW002618 FBgn0238649 FBgn0218849 FBgn0217903 FBgn0203249 FBgn0185486 FBgn0169518 JGI_V11_199063 FBgn0070654 FBgn0153660 FBgn0135303 FBgn0123238 FBgn0107421 FBgn0101226 CPIJ005584 BGIBMGA003493 ACYPI001763 GB10614 AGAP010714 AAEL008740 PB25993 PHUM037790 GLEAN_01699
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	2459 Sc21/TM6B, Tb1 5160 bw1; Sc2A4 st1/TM6B, Tb+ 5161 bw1; Sc2F9 st1/TM6B, Tb+ 11666 P{PZ}Sc205634 ry506/TM3, ryRK Sb1 Ser1 19824 y1 w67c23; P{EPgy2}Sc2EY02236/TM3, Sb1 Ser1 23301 y1 w*; P{UASp-YFP.Rab8.Q67L}Sc210/TM3, P{Thb8-lacZ}WD1, Sb1 Ser1
Kyoto	107343 Sc21/TM6B, Tb1 124266 w1118; P{RS3}Sc2CB-6976-3 / TM6C, Sb1 113462 w*; P{GawB}Sc2NP4464 / TM6, P{UAS-lacZ.UW23-1}UW23-1 104453 w*; P{GawB}Sc2NP3321 / TM6, Sb1 Tb1
VDRC	v7480 w1118; P{GD2286}v7480
Genomic Clones ( 1 )
	BACR28E17 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 65 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD09294
Other clones	FI06688
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT07586 GH05622 GH11920 GH22813 GH24806 GH25459 GM26305 LP06296 RE06054 RE11252 RE15388 RE28346 RE29543 RE32528 RE37581 RE50371 RE53406 RE60787 SD26740
Other clones	35349 53500 56958 101916 107940 173611 181088 214339.18 533567 bs18b01 bs43h12 Dmel_dig_006887_0674_1307 Dmel_neb_014979_0884_1554 EC38814 EK146426 EK152001 EK170525 EK170844 EK185506 EK228618 EK233736 EK278011 EK286016 EN09750 EP00417 FGM309A04 IP12419 RP004029967 RP004091963 RP004099632 RP004112567 RP004142090 RP004149054 RP004158336 RP004209203 RP004214293 RP004222654 RP004246984 RP004247189 RP004247733 RP004419811 RP004424445 RP004491114 RP004500151
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035471 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38457
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Sc2 CG10849 (Vaskova et al., 2000) Source for identity of: Sc2 l(3)63Eb (Vaskova et al., 2000)
Source for database merge of
Additional comments	The insertion in the "l(3)05634" line is within the Sc2 gene, rather than affecting Ubi-p63E as stated in FBrf0111489. (Vaskova et al., 2000) The insertion in the "l(3)05634" line is stated to affect Ubi-p63E in this paper. A subsequent publication suggests that this is incorrect and the insertion is in fact in Sc2 (see FBrf0130136). (Spradling et al., 1999)
Other Comments
	Discussed during genetic analysis of the Ras64B-Rop region. (Harrison et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139579 RefSeq (Proteins) • NP_647836 DDBJ / EMBL / GenBank • AAF47807 AAL29169 AI405453 AI542826 AI945897 AW944585 AY061621 G01167 Entrez Gene - A searchable database of RefSeq genes. • 38457 UniProtKB/TrEMBL • Q9VZL3 Q95R45
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal (IPR001104) Ubiquitin supergroup (IPR019955)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63945 DroID - A comprehensive database of gene and protein interactions. • FBgn0035471 DRSC - Results from RNAi screens. • FBgn0035471 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035471 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10849-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035471 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38457 InParanoid A subset of ortholog calls from InParanoid. • AAEL008740-PA Aedes aegypti (mosquito) AGAP010714-PA Anopheles gambiae (mosquito) XP_001120311.1 Apis mellifera (honey bee) XP_001950623.1 Acyrthosiphon pisum (pea aphid) At3g55360.1 Arabidopsis thaliana (wall cress) 12866 Batrachochytrium dendrobatidis (chytrid fungus) 123019 Branchiostoma floridae (lancelet) BGIBMGA003493-PA Bombyx mori (silk worm) ENSBTAP00000050712 Bos taurus (bovine) CAL0003440 Candida albicans (a form of yeast) CN03194 Caenorhabditis brenneri (small nematode) CBP02739 Caenorhabditis briggsae (nematode) CE20509 Caenorhabditis elegans (worm) ENSCAFP00000023972 Canis familiaris (dog) CAGL0K01837g Candida glabrata (haploid yeast) Chro.20132 Cryptosporidium hominis (obligate parasite) ENSCINP00000008647 Ciona intestinalis (sea squirt) JA11518 Caenorhabditis japonica (nematode) CMD146C Cyanidioschyzon merolae (red alga) cn05180 Cryptococcus neoformans (yeast-like fungus) cgd2_1200 Cryptosporidium parvum (protozoan parasite) CPIJ005584 Culex pipens (mosquito) ENSCPOP00000013003 Cavia porcellus (guinea pig) 602 Chlamidomonas reinhardtii (green alga) RP03457 Caenorhabditis remanei (nematode) ENSCSAVP00000018714 Ciona savignyi (sedentary tunicate) 167372 Capitella spl (polychaete worm) DDB0237530 Dictyostelium discoideum (amoeba) DEHA2B00968g Debaryomyces Hansenii (yeast) 199063 Daphnia pulex (daphnia) ENSDARP00000095385 Danio rerio (zebra fish) ENSECAP00000016737 Equus caballus (horse) XP_657257 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024895 Gymnopilus aculeatus (mushroom) ENSGALP00000009263 Gallus gallus (chicken) GL50803_88581 Giardia lamblia (flagellated protozoan) 155722 Hypsipyla robusta (cedar shoot borer) ENSP00000215567 Homo sapiens (human) ISCW002618-PA Ixodes scapularis (deer tick) KLLA0C04367g Kluyveromyces lactis (yeast) 232335 Lottia gigantea (owl limpet) LmjF25.1770 Leishmania major (virus) ENSMODP00000032508 Monodelphis domestica (gray opossum) ENSMMUP00000028466 Macaca mulatta (rhesus monkey) ENSMUSP00000019382 Mus musculus (house mouse) 147144 Nematostella vectensis (starlet anemone) XP_001601952.1 Nasonia vitripennis (wasp) ENSOANP00000006129 Ornithorynchus anatinus (platypus) ENSORLP00000018633 Oryzias latipes (japanese killifish) LOC_Os01g05670.1 Oryza sativa (asian rice) 16084 Ostreococcus tauri (green alga) PHUM003357-PA Pediculus humanus (human body louse) PP14200 Pristionchus pacificus (nematode) 203665 Physcomitrella patens (moss) ENSPPYP00000010812 Pongo pygmaeus (orangutan) 71193 Phytophthora ramorum (sudden oak death pathogen) 720621 Populus trichocarpa (black cottonwood) ENSPTRP00000018079 Pan troglodytes (chimpanzee) PVX_092410 Plasmodium vivax (protozoal parasite) ENSRNOP00000025594 Rattus norvegicus (norway rat) 4751185 Sorghum bicolor (sorghum) YDL015C Saccharomyces cerevisiae (budding yeast) Smp_081820.3 Schistosoma mansoni (trematode parasite) SPBC646.07c Schizosaccharomyces pombe (fission yeast) XP_001176486.1 Strongylocentrotus purpuratus (purple sea urchin) 29423 Trichoplax adhaerens (metazoa) TA18840 Theileria annulata (apicomplexan parasite) XP_971180.1 Tribolium castaneum (red flour beetle) Tc00.1047053457251.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000017099 Tetraodon nigroviridis (green spotted pufferfish) TP03_0656 Theileria parva (parasitic protozoan) 33911 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010871 Takifugu rubripes (pufferfish Takifugu) 3713.m00083 Tetrahymena thermophila (ciliate protozoa) 88043.m00118 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000044498 Xenopus tropicalis (frog) YALI0A04983g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38457 modMine - Data generated by the modENCODE project. • FBgn0035471 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11303 LH19085 ISCW002618 FBgn0238649 FBgn0218849 FBgn0217903 FBgn0203249 FBgn0185486 FBgn0169518 JGI_V11_199063 FBgn0070654 FBgn0153660 FBgn0135303 FBgn0123238 FBgn0107421 FBgn0101226 CPIJ005584 BGIBMGA003493 ACYPI001763 GB10614 AGAP010714 AAEL008740 PB25993 PHUM037790 GLEAN_01699
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	CG10849 (Roxstrom-Lindquist et al., 2004, Keleman et al., 2009.8.5, Cammarato et al., 2011) dSc2 (Bentley et al., 2002, Vaskova et al., 2000) l(3)63Eb (Harrison, 1999.5.12, Wohlwill and Bonner, 1991, ) l(3)05634 (Abrell et al., 2000, Spradling et al., 1999, Carrera et al., 1998, Spradling et al., 1995, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(3)SH4 (Harrison et al., 1995) Sc2 (Christensen et al., 2007.10.29, Buszczak et al., 2007, Zhang et al., 2007, Branco et al., 2008, Patch et al., 2009, Chen et al., 2010)
Name Synonym	lethal(3)63Eb   Sc2 (Branco et al., 2008, Patch et al., 2009, Cammarato et al., 2011) Ubiquitin-63E (Abrell et al., 2000)
Secondary FlyBase IDs
	FBgn0002196 FBgn0010871
References ( 35 )
Generate a list of	All references relating to this gene ( 35 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) FlyBase analysis  ( 2 ) Computer file  ( 2 ) Book  ( 1 )
Recent research papers ( 1 )
	Chen et al., 2010, Hum. Mol. Genet. 19(3): 494--505 Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. [FBrf0209624] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...