Gene Dmel\CG11586

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General Information

Symbol

Dmel\CG11586

Species

D. melanogaster

Name

Annotation symbol

CG11586

Feature type

protein_coding_gene

FlyBase ID

FBgn0035520

Gene Model Status

Current

Stock availability

5 publicly available

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

64A12-64A12

Sequence location

3L:4,261,297..4,262,470 [-]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG11586 (FBgn0035520). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. The biological processes in which it is involved are not known. 5 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Zinc finger, C2H2-like; Zinc finger, U1-type; Zinc finger, double-stranded RNA binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye. Comments on Affy2 ProbeSet: ProbeSet 1630952_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11586. Gene sequence location is 3L:4261297..4262470.

User Contributed Data

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Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

64A12-64A12

Limits computationally determined from genome sequence between P{PZ}l(3)rG166^rG166 and P{PZ}sinu⁰⁶⁵²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG11586 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG11586-RA

FBtr0073243

NM_139624

1115

194

CG11586-RB

FBtr0333568

NM_001274481

760

194

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG11586-PA

FBpp0073099

22.9

194

9.76

NP_647881

AAF47873

CG11586-PB

FBpp0305745

22.9

194

9.76

NP_001261410

AGB94105

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, C2H2-like (IPR015880)

Zinc finger, U1-type (IPR003604)

Zinc finger, double-stranded RNA binding (IPR022755)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VZF0

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult eye.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		94.1
Larval Midgut		36.9
Larval Hindgut		50.6
Larval Malpighian Tubules		42.9
Larval Fat Body		47.7
Larval Salivary Gland		74.2
Larval Trachea		65.275
Larval Carcass		51.325
Adult Head		53.9
Adult Eye		215.8
Adult Brain		65.4
Adult Thoracic-Abdominal Ganglion		57.2
Adult Crop		55.4
Adult Midgut		27.8
Adult Hindgut		36.4
Adult Malpighian Tubules		32.1
Adult Fat Body		48.8
Adult Salivary Gland		60.1
Adult Heart		54.875
Adult VirginFemale Spermatheca		54.1
Adult InseminatedFemale Spermatheca		62.3
Adult Ovary		93.3
Adult Testis		69.7
Adult Male Accessory Gland		50.6
Adult Carcass		53.4
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	53.9
NA	Eye	215.8
NA	Brain	65.4
94.1	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	57.2
NA	Crop	55.4
no informative data	Midgut	no informative data
50.6	Hindgut	36.4
42.9	Malpighian Tubules	32.1
47.7	Fat Body	48.8
74.2	Salivary Gland	60.1
NA	Heart	54.875
65.275	Trachea	NA
NA	VirginFemale Spermatheca	54.1
NA	InseminatedFemale Spermatheca	62.3
NA	Ovary	93.3
NA	Testis	69.7
NA	Male Accessory Gland	50.6
51.325	Carcass	53.4

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		78
central nervous system, larvae L3		52
central nervous system, pupae P8		33
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		36
head, mated 4-day male		38
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		72
carcass, larvae L3 wandering		39
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		53
ovary, mated 4-day female		69
testis, mated 4-day male		151
accessory gland, mated 4-day male		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(78)
central nervous system, larvae L3		(52)
central nervous system, pupae P8		(33)
head, virgin 1-day female		(28)
head, virgin 4-day female		(27)
head, virgin 20-day female		14
head, mated 1-day female		(31)
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		(36)
head, mated 4-day male		(38)
head, mated 20-day male		(31)
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		(72)
carcass, larvae L3 wandering		(39)
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		(53)
ovary, mated 4-day female		(69)
testis, mated 4-day male		(151)
accessory gland, mated 4-day male		(27)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		78
central nervous system, larvae L3		52
central nervous system, pupae P8		33
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		36
head, mated 4-day male		38
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		72
carcass, larvae L3 wandering		39
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		53
ovary, mated 4-day female		69
testis, mated 4-day male		(151)
accessory gland, mated 4-day male		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		78
central nervous system, larvae L3		52
central nervous system, pupae P8		33
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		36
head, mated 4-day male		38
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		72
carcass, larvae L3 wandering		39
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		53
ovary, mated 4-day female		69
testis, mated 4-day male		151
accessory gland, mated 4-day male		27
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		78
central nervous system, larvae L3		52
central nervous system, pupae P8		33
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		36
head, mated 4-day male		38
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		72
carcass, larvae L3 wandering		39
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		53
ovary, mated 4-day female		69
testis, mated 4-day male		151
accessory gland, mated 4-day male		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(78)
central nervous system, larvae L3		(52)
central nervous system, pupae P8		(33)
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		(36)
head, mated 4-day male		(38)
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		(72)
carcass, larvae L3 wandering		(39)
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		(53)
ovary, mated 4-day female		(69)
testis, mated 4-day male		(151)
accessory gland, mated 4-day male		27
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		78
central nervous system, larvae L3		52
central nervous system, pupae P8		33
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		36
head, mated 4-day male		38
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		72
carcass, larvae L3 wandering		39
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		53
ovary, mated 4-day female		69
testis, mated 4-day male		(151)
accessory gland, mated 4-day male		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		78
central nervous system, larvae L3		52
central nervous system, pupae P8		33
head, virgin 1-day female		28
head, virgin 4-day female		27
head, virgin 20-day female		14
head, mated 1-day female		31
head, mated 4-day female		25
head, mated 20-day female		13
head, mated 1-day male		36
head, mated 4-day male		38
head, mated 20-day male		31
salivary gland, larvae L3 wandering		11
salivary gland, white prepupae		19
digestive system, larvae L3 wandering		26
digestive system, 1-day adult		17
digestive system, 4-day adult		15
digestive system, 20-day adult		12
fat body, larvae L3 wandering		13
fat body, white prepupae		26
fat body, pupae P8		72
carcass, larvae L3 wandering		39
carcass, 1-day adult		15
carcass, 4-day adult		16
carcass, 20-day adult		13
ovary, virgin 4-day female		53
ovary, mated 4-day female		69
testis, mated 4-day male		151
accessory gland, mated 4-day male		27
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		43
embryo 02-04hr		59
embryo 04-06hr		54
embryo 06-08hr		53
embryo 08-10hr		50
embryo 10-12hr		46
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(43)
embryo 02-04hr		(59)
embryo 04-06hr		(54)
embryo 06-08hr		(53)
embryo 08-10hr		(50)
embryo 10-12hr		(46)
embryo 12-14hr		(29)
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		(28)
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		(28)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		43
embryo 02-04hr		59
embryo 04-06hr		54
embryo 06-08hr		53
embryo 08-10hr		50
embryo 10-12hr		46
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		43
embryo 02-04hr		59
embryo 04-06hr		54
embryo 06-08hr		53
embryo 08-10hr		50
embryo 10-12hr		46
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		43
embryo 02-04hr		59
embryo 04-06hr		54
embryo 06-08hr		53
embryo 08-10hr		50
embryo 10-12hr		46
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(43)
embryo 02-04hr		(59)
embryo 04-06hr		(54)
embryo 06-08hr		(53)
embryo 08-10hr		(50)
embryo 10-12hr		(46)
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		43
embryo 02-04hr		59
embryo 04-06hr		54
embryo 06-08hr		53
embryo 08-10hr		50
embryo 10-12hr		46
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		43
embryo 02-04hr		59
embryo 04-06hr		54
embryo 06-08hr		53
embryo 08-10hr		50
embryo 10-12hr		46
embryo 12-14hr		29
embryo 14-16hr		26
embryo 16-18hr		20
embryo 18-20hr		14
embryo 20-22hr		17
embryo 22-24hr		16
larva L1		12
larva L2		12
larva L3 12hr old		9
larva L3 puffstage 1-2		14
larva L3 puffstage 3-6		18
larva L3 puffstage 7-9		22
white prepupae new		23
white prepupae 12hr		24
white prepupae 24hr		28
pupae 2d postWPP		25
pupae 3d postWPP		19
pupae 4d postWPP		13
adult male 01day		18
adult male 05day		22
adult male 30day		20
adult female 01day		17
adult female 05day		26
adult female 30day		28
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		98
Schneider line 2 Sg4		38
embryonic 1182-4H		60
embryonic GM2		26
embryonic Kc167		40
embryonic S1		107
embryonic S3		42
leg disc CME L1		56
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		91
wing disc ML-DmD16-c3		53
wing disc ML-DmD21		96
wing disc ML-DmD32		73
haltere disc ML-DmD17-c3		53
eye-antennal disc ML-DmD11		80
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		37
tumorous blood cells mbn2		42
ovary fGS/OSS		49
ovary OSC		43
ovary OSS		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(98)
Schneider line 2 Sg4		(38)
embryonic 1182-4H		(60)
embryonic GM2		26
embryonic Kc167		(40)
embryonic S1		(107)
embryonic S3		(42)
leg disc CME L1		(56)
wing disc CME-W2		(28)
wing disc ML-DmD8		(29)
wing disc ML-DmD9		(91)
wing disc ML-DmD16-c3		(53)
wing disc ML-DmD21		(96)
wing disc ML-DmD32		(73)
haltere disc ML-DmD17-c3		(53)
eye-antennal disc ML-DmD11		(80)
antennal disc ML-DmD20-c5		(64)
mixed discs ML-DmD4-c1		(43)
CNS ML-DmBG1-c1		(88)
CNS ML-DmBG2-c2		(37)
tumorous blood cells mbn2		(42)
ovary fGS/OSS		(49)
ovary OSC		(43)
ovary OSS		(31)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		98
Schneider line 2 Sg4		38
embryonic 1182-4H		60
embryonic GM2		26
embryonic Kc167		40
embryonic S1		107
embryonic S3		42
leg disc CME L1		56
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		91
wing disc ML-DmD16-c3		53
wing disc ML-DmD21		96
wing disc ML-DmD32		73
haltere disc ML-DmD17-c3		53
eye-antennal disc ML-DmD11		80
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		37
tumorous blood cells mbn2		42
ovary fGS/OSS		49
ovary OSC		43
ovary OSS		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		98
Schneider line 2 Sg4		38
embryonic 1182-4H		60
embryonic GM2		26
embryonic Kc167		40
embryonic S1		107
embryonic S3		42
leg disc CME L1		56
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		91
wing disc ML-DmD16-c3		53
wing disc ML-DmD21		96
wing disc ML-DmD32		73
haltere disc ML-DmD17-c3		53
eye-antennal disc ML-DmD11		80
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		37
tumorous blood cells mbn2		42
ovary fGS/OSS		49
ovary OSC		43
ovary OSS		31
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		98
Schneider line 2 Sg4		38
embryonic 1182-4H		60
embryonic GM2		26
embryonic Kc167		40
embryonic S1		107
embryonic S3		42
leg disc CME L1		56
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		91
wing disc ML-DmD16-c3		53
wing disc ML-DmD21		96
wing disc ML-DmD32		73
haltere disc ML-DmD17-c3		53
eye-antennal disc ML-DmD11		80
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		37
tumorous blood cells mbn2		42
ovary fGS/OSS		49
ovary OSC		43
ovary OSS		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(98)
Schneider line 2 Sg4		(38)
embryonic 1182-4H		(60)
embryonic GM2		26
embryonic Kc167		(40)
embryonic S1		(107)
embryonic S3		(42)
leg disc CME L1		(56)
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		(91)
wing disc ML-DmD16-c3		(53)
wing disc ML-DmD21		(96)
wing disc ML-DmD32		(73)
haltere disc ML-DmD17-c3		(53)
eye-antennal disc ML-DmD11		(80)
antennal disc ML-DmD20-c5		(64)
mixed discs ML-DmD4-c1		(43)
CNS ML-DmBG1-c1		(88)
CNS ML-DmBG2-c2		(37)
tumorous blood cells mbn2		(42)
ovary fGS/OSS		(49)
ovary OSC		(43)
ovary OSS		31
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		98
Schneider line 2 Sg4		38
embryonic 1182-4H		60
embryonic GM2		26
embryonic Kc167		40
embryonic S1		107
embryonic S3		42
leg disc CME L1		56
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		91
wing disc ML-DmD16-c3		53
wing disc ML-DmD21		96
wing disc ML-DmD32		73
haltere disc ML-DmD17-c3		53
eye-antennal disc ML-DmD11		80
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		37
tumorous blood cells mbn2		42
ovary fGS/OSS		49
ovary OSC		43
ovary OSS		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		98
Schneider line 2 Sg4		38
embryonic 1182-4H		60
embryonic GM2		26
embryonic Kc167		40
embryonic S1		107
embryonic S3		42
leg disc CME L1		56
wing disc CME-W2		28
wing disc ML-DmD8		29
wing disc ML-DmD9		91
wing disc ML-DmD16-c3		53
wing disc ML-DmD21		96
wing disc ML-DmD32		73
haltere disc ML-DmD17-c3		53
eye-antennal disc ML-DmD11		80
antennal disc ML-DmD20-c5		64
mixed discs ML-DmD4-c1		43
CNS ML-DmBG1-c1		88
CNS ML-DmBG2-c2		37
tumorous blood cells mbn2		42
ovary fGS/OSS		49
ovary OSC		43
ovary OSS		31
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		35
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		53
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		46
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		43
Paraquat 10 mM 48 hrs, 4-day adult		47
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(35)
cold shock, 4-day adult		(30)
heat shock, 4-day adult		(28)
Cadmium 50 mM 6 hrs, larvae L3		(27)
Cadmium 50 mM 12 hrs, larvae L3		(31)
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		(53)
Copper 0.5 mM 12 hrs, larvae L3		(31)
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		(46)
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(48)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(32)
Paraquat 5 mM 48 hrs, 4-day adult		(43)
Paraquat 10 mM 48 hrs, 4-day adult		(47)
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		(29)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		35
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		53
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		46
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		43
Paraquat 10 mM 48 hrs, 4-day adult		47
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		35
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		53
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		46
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		43
Paraquat 10 mM 48 hrs, 4-day adult		47
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		35
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		53
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		46
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		43
Paraquat 10 mM 48 hrs, 4-day adult		47
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(35)
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		(53)
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		(46)
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(48)
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		(43)
Paraquat 10 mM 48 hrs, 4-day adult		(47)
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		35
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		53
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		46
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		43
Paraquat 10 mM 48 hrs, 4-day adult		47
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		35
cold shock, 4-day adult		30
heat shock, 4-day adult		28
Cadmium 50 mM 6 hrs, larvae L3		27
Cadmium 50 mM 12 hrs, larvae L3		31
Cadmium 50 mM 48 hrs, 4-day adult		26
Cadmium 100 mM 48 hrs, 4-day adult		53
Copper 0.5 mM 12 hrs, larvae L3		31
Copper 15 mM 48 hrs, 4-day adult		23
Zinc 5 mM 12 hrs, larvae L3		20
Zinc 4.5 mM 48 hrs, 4-day adult		25
Ethanol 2.5% 3 hrs, larvae L3		46
Ethanol 5% 3 hrs, larvae L3		19
Ethanol 10% 3 hrs, larvae L3		16
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		32
Paraquat 5 mM 48 hrs, 4-day adult		43
Paraquat 10 mM 48 hrs, 4-day adult		47
Rotenone 2 μg 12 hrs, larvae L3		17
Rotenone 8 μg 12 hrs, larvae L3		29
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

BDGP expression data

•

LD44732

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0035520

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG11586-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

CG11586^GD7337

Other Phenotypes

Allele

visible, with Scer\GAL4^pnr-MD237

CG11586^GD7337

Phenotype manifest in

Allele

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CG11586^GD7337

trichogen cell, with Scer\GAL4^pnr-MD237

CG11586^GD7337

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of CG11586	Class	Mutagen	Stocks	Known lesion
CG11586^G19133		P-element activity	1	--
CG11586^MI01616			1	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG11586	Mutagen	Stocks	Known lesion
CG11586^GD7337	in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
CG11586^KK107848	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
CG11586^NIG.11586R	in vitro construct - RNAi in vitro construct - regulatory fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(3L)Exel8098

(Ryder, 2004.4.26)

Df(3L)Exel9000

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD7337}

P{KK107848}

P{NIG.11586R}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}CG11586^G19133

miscellaneous insertions

Mi{MIC}CG11586^MI01616

Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 2 terms )

Molecular Function

CV term

Evidence

References

nucleic acid binding

inferred from electronic annotation with InterPro:IPR003604

(FlyBase Curators et al., 2004-)

zinc ion binding

inferred from electronic annotation with InterPro:IPR003604, InterPro:IPR015880

(FlyBase Curators et al., 2004-)

Biological Process ( 0 terms)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG11586 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

63998

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0035520

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

38520

Orthologs

OrthoDB Orthologs (39) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG67WP88

Dipteran inclusive ortholog search

EOG6C5CTT

Insect inclusive ortholog search

EOG69P8W2

Arthropod inclusive ortholog search

EOG6Z6156

Metazoa inclusive ortholog search

EOG67DPBF

Orthologs in Drosophila Species (EOG67WP88)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11083

Drosophila persimilis

Dper\GL12725

Drosophila willistoni

Dwil\GK10568

Drosophila virilis

Dvir\GJ12561

Drosophila mojavensis

Dmoj\GI16814

Drosophila grimshawi

Dgri\GH15537

Orthologs in non-Drosophila Dipterans (EOG6C5CTT)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL001945

Anopheles gambiae

Malaria mosquito

Agam\AGAP006245

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ009914

Orthologs in non-Dipteran Insects (EOG69P8W2)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB41492

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013363

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG013359

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH14682

Atta cephalotes

Leafcutter ant

Acep\ACEP24085

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO13950

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL18735

Linepithema humile

Argentine ant

Lhum\LH18811

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB11627

Solenopsis invicta

Red fire ant

Sinv\SINV11181

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009162

Bombyx mori

Silkmoth

Bmor\BGIBMGA000360

Pediculus humanus

Human body louse

Phum\PHUM117550

Tribolium castaneum

Red flour beetle

Tcas\TC016272

Orthologs in non-Insect Arthropods (EOG6Z6156)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\ZFAM6

Ixodes scapularis

Deer tick

Isca\ISCW010148

Orthologs in non-Arthropod Metazoa (EOG67DPBF)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\ZK686.4

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_010009gn

Danio rerio

Zebrafish

Drer\zmat2

Xenopus tropicalis

Western clawed frog

Xtro\zmat2

Gallus gallus

Domestic chicken

Ggal\ZMAT2

Mus musculus

House mouse

Mmus\Zmat2

Rattus norvegicus

Norway rat

Rnor\Zmat2

Homo sapiens

Human

Hsap\ZMAT2

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\ZMAT2

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11083

Drosophila persimilis

Dper\GL12725

Drosophila willistoni

Dwil\GK10568

Drosophila virilis

Dvir\GJ12561

Drosophila mojavensis

Dmoj\GI16814

Drosophila grimshawi

Dgri\GH15537

Stocks & Reagents

Stocks Listed in FlyBase ( 5 )

Bloomington

29677

y¹ w^*; P{EP}CG11586^G19133

34223

y¹ w^*; Mi{MIC}CG11586^MI01616 CG1309^MI01616/TM3, Sb¹ Ser¹

VDRC

v104359

P{KK107848}VIE-260B

v31531

w¹¹¹⁸; P{GD7337}v31531/TM3

v31532

w¹¹¹⁸; P{GD7337}v31532/CyO

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 31 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

LD44732

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0035520

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

38520

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

RefSeq (Proteins)

•

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

38520

UniProtKB/TrEMBL

•

Q9VZF0

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Zinc finger, C2H2-like (IPR015880)

Zinc finger, U1-type (IPR003604)

Zinc finger, double-stranded RNA binding (IPR022755)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

LD44732

Linkouts

BioGRID - A database of protein and genetic interactions

•

63998

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0035520

DRSC - Results from RNAi screens.

•

FBgn0035520

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0035520

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG11586-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0035520

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

38520

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

38520

modMine - Data generated by the modENCODE project.

•

FBgn0035520

Synonyms & Secondary IDs ( 1 )

Reported As

Symbol Synonym

CG11586

(Gonsalves et al., 2011, Keleman et al., 2009.8.5, Japanese National Institute of Genetics, 2012.5.21)

Name Synonym

Secondary FlyBase IDs

References ( 17 )

Research paper

Gonsalves et al., 2011, BMC Genomics 12: 475: Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. [FBrf0216487]
Page et al., 2005, EMBO J. 24(24): 4304--4315: Spotted-dick, a zinc-finger protein of Drosophila required for expression of Orc4 and S phase. [FBrf0190363]
Brody et al., 2002, Mech. Dev. 113(1): 41--59: Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. [FBrf0147137]

Supplementary material

Graveley et al., 2011, Nature 471(7339):: Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980]
The modENCODE Consortium, 2010, Science 330(6012):: DataS14: Gene co-expression clusters. [FBrf0213979]
Mummery-Widmer et al., 2009, Nature 458(7241):: Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Giot et al., 2003, Science 302(5651):: Tables S1 to S7. [FBrf0166452]

Personal communication to FlyBase

Bellen, 2011.1.31, set919.xml: set919.xml [FBrf0212923]
Bellen, 2009.12.18, BDGP_2009_1221.GenExel.xml: BDGP_2009_1221.GenExel.xml [FBrf0209716]
Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510]
Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center: RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327]
FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
Ryder, 2004.4.26, Exelixis CG deletion data.: Exelixis CG deletion data. [FBrf0184335]
BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file): Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]

Stock list

Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.: RNAi stocks available from NIG-FLY. [FBrf0218457]

Website

Fisher et al., 2012, BDGP insitu homepage: BDGP insitu homepage [FBrf0219073]