FB2020_06, released Dec 22, 2020

Gene: Dmel\Cip4

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General Information
Symbol
Dmel\Cip4
Species
D. melanogaster
Name
Cdc42-interacting protein 4
Annotation Symbol
CG15015
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035533
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Cdc42-interacting protein 4 (Cip4) encodes an F-BAR protein that functions as an adaptor protein regulating membrane curvature and dynamics. [Date last reviewed: 2019-09-12]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
64B1-64B2
Sequence location
3L:4,322,491..4,364,102 [-]
Recombination map

3-12

RefSeq locus
NT_037436 REGION:4322491..4364102
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
enables GTPase activating protein binding
inferred from physical interaction with FLYBASE:RhoGAP92B; FB:FBgn0038747
(Nahm et al., 2010)
enables lipid binding
inferred from direct assay
(Zobel et al., 2015)
enables protein binding
inferred from physical interaction with FLYBASE:dia; FB:FBgn0011202, FLYBASE:SCAR; FB:FBgn0041781
(Yan et al., 2013)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables phospholipid binding
inferred from sequence model
(Takeda et al., 2013)
Biological Process (14 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
involved_in cellular protein localization
inferred from mutant phenotype
(Nahm et al., 2010)
involved_in cellularization
inferred from mutant phenotype
(Yan et al., 2013)
involved_in germarium-derived female germ-line cyst encapsulation
inferred from mutant phenotype
(Zobel et al., 2015)
involved_in imaginal disc-derived wing hair organization
inferred from mutant phenotype
(Zobel et al., 2015, Fricke et al., 2009)
involved_in mesoderm development
inferred from expression pattern
(Furlong et al., 2001)
involved_in negative regulation of actin filament polymerization
inferred from direct assay
(Yan et al., 2013)
involved_in negative regulation of actin nucleation
inferred from direct assay
(Yan et al., 2013)
involved_in negative regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Nahm et al., 2010)
involved_in plasma membrane organization
inferred from mutant phenotype
(Zobel et al., 2015)
involved_in plasma membrane tubulation
inferred from direct assay
(Zobel et al., 2015)
inferred from mutant phenotype
(Yan et al., 2013)
involved_in protein localization
inferred from mutant phenotype
(Yan et al., 2013)
involved_in regulation of adherens junction organization
inferred from mutant phenotype
(Zobel et al., 2015)
involved_in regulation of synaptic growth at neuromuscular junction
inferred from direct assay
(Nahm et al., 2010)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in signal transduction
inferred from electronic annotation with InterPro:IPR011072
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in cleavage furrow
inferred from direct assay
(Yan et al., 2013)
located_in midbody
inferred from direct assay
(Takeda et al., 2013)
located_in neuromuscular junction
inferred from direct assay
(Nahm et al., 2010)
located_in plasma membrane
inferred from direct assay
(Yan et al., 2013)
located_in vesicle membrane
inferred from direct assay
(Yan et al., 2013)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
10

Please see the JBrowse view of Dmel\Cip4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cip4-RA
FBtr0073339
NM_139636
2525
631
Cip4-RB
FBtr0113138
NM_001104031
2637
665
Cip4-RC
FBtr0306094
NM_001259691
2468
612
Cip4-RD
FBtr0306095
NM_001259692
2580
646
Cip4-RE
FBtr0306096
NM_001259693
2504
624
Cip4-RF
FBtr0306533
NM_001259689
2414
628
Cip4-RG
FBtr0306534
NM_001259690
3507
612
Cip4-RH
FBtr0308201
NM_001259687
3422
644
Cip4-RI
FBtr0308202
NM_001259688
3359
623
Cip4-RJ
FBtr0333570
NM_001274483
3477
602
Cip4-RK
FBtr0333571
NM_001274484
3504
611
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cip4-PA
FBpp0073195
70.4
631
5.10
NP_647893
AAF47887
Cip4-PB
FBpp0112051
74.1
665
5.63
NP_001097501
ABW08460
Cip4-PC
FBpp0297231
68.3
612
5.16
NP_001246620
AFH04291
Cip4-PD
FBpp0297232
72.0
646
5.77
NP_001246621
AFH04292
Cip4-PE
FBpp0297233
69.7
624
5.23
NP_001246622
AFH04293
Cip4-PF
FBpp0297491
70.2
628
5.10
NP_001246618
AFH04289
Cip4-PG
FBpp0297492
68.3
612
5.16
NP_001246619
AFH04290
Cip4-PH
FBpp0300521
71.9
644
5.17
NP_001246616
AFH04287
Cip4-PI
FBpp0300522
69.6
623
5.23
NP_001246617
AFH04288
Cip4-PJ
FBpp0305747
67.3
602
5.15
NP_001261412
AGB94107
Cip4-PK
FBpp0305748
68.2
611
5.16
NP_001261413
AGB94108
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

612 aa isoforms: Cip4-PC, Cip4-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cip4 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 5
organism
(Nahm et al., 2010)
embryonic stage 13
embryonic/larval brain
(Nahm et al., 2010)
ventral midline of embryo
(Nahm et al., 2010)
epithelium
(Nahm et al., 2010)
embryonic stage 16
embryonic/larval brain
(Nahm et al., 2010)
ventral midline of embryo
(Nahm et al., 2010)
epithelium
(Nahm et al., 2010)
embryonic/larval salivary gland
(Nahm et al., 2010)
third instar larval stage
embryonic/larval central nervous system
• synapse
(Nahm et al., 2010)
embryonic/larval neuromuscular junction of glutamatergic neuron
(Nahm et al., 2010)
embryonic/larval neuromuscular junction
(Nahm et al., 2010)
Additional Descriptive Data

Cip4 protein is expressed at the cell borders in early embryos. From stage 13 to 16 it labels the brain, ventral midline and the surface epithelium, and the salivary glands in the latter stage only. In third instar larva it localises to the synaptic domains of the central nervous system. At the neuromuscular junction Cip4 is present at the postsynaptic domain of glutamatergic type I boutons.

(Nahm et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cleavage furrow
inferred from direct assay
(Yan et al., 2013)
located_in midbody
inferred from direct assay
(Takeda et al., 2013)
located_in neuromuscular junction
inferred from direct assay
(Nahm et al., 2010)
located_in plasma membrane
inferred from direct assay
(Yan et al., 2013)
located_in vesicle membrane
inferred from direct assay
(Yan et al., 2013)
Expression Deduced from Reporters
Reporter: PBac{754.P.FSVS-0}Cip4CPTI003231
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | faint | ubiquitous
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cip4 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cip4
Transgenic constructs containing regulatory region of Cip4
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3L)Exel8098)
partially lethal - majority die
partially lethal - majority die | adult stage, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
increased cell size, with Scer\GAL4ap.PU
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4C57
neuroanatomy defective (with Df(3L)ED4342)
neuroanatomy defective | third instar larval stage (with Df(3L)ED4342)
visible
visible, with Scer\GAL4en.PU
visible, with Scer\GAL4en-e16E
visible (with Df(3L)Exel8098)
Phenotype manifest in
Allele
adherens junction, with Scer\GAL4ap.PU
bouton, with Scer\GAL4C57
egg chamber
neuromuscular junction
neuromuscular junction, with Scer\GAL4C57
neuromuscular junction (with Df(3L)ED4342)
NMJ bouton
NMJ bouton (with Df(3L)ED4342)
NMJ bouton | third instar larval stage (with Df(3L)ED4342)
wing, with Scer\GAL4en.PU
wing hair | supernumerary
wing hair | supernumerary, with Scer\GAL4en.PU
wing hair | supernumerary, with Scer\GAL4en-e16E
wing hair | supernumerary (with Df(3L)Exel8098)
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\TRIP10
14 of 15
Yes
Yes
0  
Hsap\FNBP1
13 of 15
No
Yes
Hsap\FNBP1L
13 of 15
No
Yes
Hsap\FCHSD1
3 of 15
No
No
Hsap\FCHSD2
2 of 15
No
No
Hsap\ARHGAP4
1 of 15
No
Yes
Hsap\GRAP2
1 of 15
No
No
Hsap\ITSN1
1 of 15
No
No
Hsap\ITSN2
1 of 15
No
No
1  
Hsap\PACSIN1
1 of 15
No
No
Hsap\PACSIN2
1 of 15
No
No
1  
Hsap\PACSIN3
1 of 15
No
No
1  
Hsap\SH3D19
1 of 15
No
No
Hsap\SH3YL1
1 of 15
No
Yes
Hsap\SRGAP1
1 of 15
No
Yes
Hsap\SRGAP2B
1 of 15
No
Yes
Hsap\SRGAP2C
1 of 15
No
Yes
Hsap\SRGAP2
1 of 15
No
Yes
Hsap\SRGAP3
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (17)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Trip10
14 of 15
Yes
Yes
Mmus\Fnbp1l
13 of 15
No
Yes
Mmus\Fnbp1
12 of 15
No
Yes
Mmus\Fchsd1
2 of 15
No
No
Mmus\Fchsd2
2 of 15
No
No
Mmus\Arhgap4
1 of 15
No
Yes
Mmus\Batf
1 of 15
No
No
Mmus\Itsn1
1 of 15
No
No
Mmus\Itsn2
1 of 15
No
No
Mmus\Pacsin1
1 of 15
No
No
Mmus\Pacsin2
1 of 15
No
No
Mmus\Pacsin3
1 of 15
No
No
Mmus\Sh3d19
1 of 15
No
No
Mmus\Sh3yl1
1 of 15
No
Yes
Mmus\Srgap1
1 of 15
No
Yes
Mmus\Srgap2
1 of 15
No
Yes
Mmus\Srgap3
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (9)
Rnor\Fnbp1l
10 of 13
Yes
Yes
Rnor\Fnbp1
9 of 13
No
Yes
Rnor\Trip10
7 of 13
No
Yes
Rnor\Fchsd1
2 of 13
No
No
Rnor\Fchsd2
2 of 13
No
No
Rnor\LOC108348147
2 of 13
No
Yes
Rnor\Srgap1
1 of 13
No
Yes
Rnor\Srgap2
1 of 13
No
Yes
Rnor\Srgap3
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (8)
Xtro\fnbp1l
12 of 12
Yes
Yes
Xtro\fnbp1
8 of 12
No
Yes
Xtro\fchsd1
2 of 12
No
No
Xtro\fchsd2
2 of 12
No
No
Xtro\arhgap4
1 of 12
No
Yes
Xtro\rad18
1 of 12
No
Yes
Xtro\srgap1
1 of 12
No
Yes
Xtro\srgap2
1 of 12
No
Yes
Danio rerio (Zebrafish) (23)
Drer\trip10a
13 of 15
Yes
Yes
Drer\fnbp1a
12 of 15
No
Yes
Drer\fnbp1l
11 of 15
No
Yes
Drer\trip10b
7 of 15
No
Yes
Drer\LOC562049
6 of 15
No
Yes
Drer\LOC100537850
2 of 15
No
No
Drer\si:ch211-176g13.8
2 of 15
No
No
Drer\arhgap4a
1 of 15
No
Yes
Drer\arhgap4b
1 of 15
No
Yes
Drer\itsn1
1 of 15
No
No
Drer\itsn2a
1 of 15
No
No
Drer\itsn2b
1 of 15
No
No
Drer\LOC100536453
1 of 15
No
No
Drer\LOC101884113
1 of 15
No
No
Drer\LOC101885270
1 of 15
No
No
Drer\pacsin1a
1 of 15
No
No
Drer\pacsin1b
1 of 15
No
No
Drer\pacsin3
1 of 15
No
No
Drer\sh3d19
1 of 15
No
No
Drer\srgap1a
1 of 15
No
Yes
Drer\srgap1b
1 of 15
No
Yes
Drer\srgap2
1 of 15
No
Yes
Drer\srgap3
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\toca-1
13 of 15
Yes
Yes
Cele\toca-2
8 of 15
No
Yes
Cele\sdpn-1
2 of 15
No
No
Cele\B0303.7
1 of 15
No
Yes
Cele\C26C6.8
1 of 15
No
No
Cele\itsn-1
1 of 15
No
No
Cele\mlc-7
1 of 15
No
No
Cele\srgp-1
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (3)
Atha\AT1G31440
1 of 9
Yes
No
Atha\AT4G18060
1 of 9
Yes
No
Atha\AT4G34660
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\BZZ1
8 of 15
Yes
Yes
Scer\LSB1
1 of 15
No
No
Scer\LSB3
1 of 15
No
Yes
Scer\SHO1
1 of 15
No
Yes
Scer\YSC84
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\bzz1
4 of 12
Yes
Yes
Spom\SPAPJ696.02
1 of 12
No
Yes
Spom\SPBC119.05c
1 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905ZY )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010180
Drosophila simulans
Dsim\GD13264
Drosophila sechellia
Dsec\GM13982
Drosophila erecta
Dere\GG14192
Drosophila yakuba
Dyak\GE20622
Drosophila ananassae
Dana\GF24736
Drosophila pseudoobscura pseudoobscura
Dpse\GA13434
Drosophila persimilis
Dper\GL15723
Drosophila willistoni
Dwil\GK13402
Drosophila virilis
Dvir\GJ11972
Drosophila mojavensis
Dmoj\GI13197
Drosophila grimshawi
Dgri\GH16262
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506NQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17004830
Musca domestica
House fly
Mdoa\17011258
Musca domestica
House fly
Mdoa\17005604
Glossina morsitans
Tsetse fly
Gmor\GMOY007762
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07411
Mayetiola destructor
Hessian fly
Mdes\Mdes004084
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007429
Anopheles darlingi
American malaria mosquito
Adar\ADAC010152
Anopheles gambiae
Malaria mosquito
Agam\AGAP005976
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010462
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016791
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W06B8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010380
Danaus plexippus
Monarch butterfly
Dple\DPOGS204384-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL013079
Apis florea
Little honeybee
Aflo\2598455284
Apis mellifera
Western honey bee
Amel\GB49087
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25822
Bombus terrestris
Buff-tailed bumblebee
Bter\15215444
Linepithema humile
Argentine ant
Lhum\LH18967
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000374
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003733
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10753
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10754
Tribolium castaneum
Red flour beetle
Tcas\TC014985
Tribolium castaneum
Red flour beetle
Tcas\TC034900
Pediculus humanus
Human body louse
Phum\PHUM356900
Rhodnius prolixus
Kissing bug
Rpro\RPRC002971
Cimex lectularius
Bed bug
Clec\CLEC003401
Cimex lectularius
Bed bug
Clec\CLEC003400
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007545
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00334
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X066U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009714
Ixodes scapularis
Black-legged tick
Isca\ISCW012825
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80798.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67543.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67542.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g01990
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_332246
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09HM )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fnbp1l_1
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
nwk
3 of 10
Dap160
1 of 10
Synd
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TRIP10; thyroid hormone receptor interactor 10
    14 of 15
    604504
         
        FNBP1; formin binding protein 1
        13 of 15
        606191
            FNBP1L; formin binding protein 1 like
            13 of 15
            608848
                FCHSD1; FCH and double SH3 domains 1
                3 of 15
                617555
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    Cip4
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - Abi
                    anti bait coimmunoprecipitation, western blot, two hybrid
                    (Fricke et al., 2009)
                    Cip4 - CG10809
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - CG14535
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - CG5111
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - CG5213
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - Cdc42
                    pull down, anti tag western blot, two hybrid, autoradiography, western blot
                    (Brinkmann et al., 2016, Nahm et al., 2010, Fricke et al., 2009, Leibfried et al., 2008)
                    Cip4 - Hem
                    pull down, western blot
                    (Fricke et al., 2009)
                    Cip4 - Nost
                    pull down, anti tag western blot
                    (Zobel et al., 2015)
                    Cip4 - Pu
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - RhoGAP92B
                    pull down, western blot, anti tag coimmunoprecipitation, anti tag western blot
                    (Nahm et al., 2010)
                    Cip4 - SCAR
                    anti tag coimmunoprecipitation, western blot, two hybrid, pull down, anti bait coimmunoprecipitation
                    (Hu et al., 2017.6.13, Yan et al., 2013, Fricke et al., 2009)
                    Cip4 - WASp
                    pull down, anti tag western blot, anti tag coimmunoprecipitation, western blot, two hybrid, anti bait coimmunoprecipitation, bimolecular fluorescence complementation, fluorescence microscopy
                    (Zobel et al., 2015, Nahm et al., 2010, Fricke et al., 2009, Leibfried et al., 2008)
                    Cip4 - dia
                    anti tag coimmunoprecipitation, western blot, pull down, molecular weight estimation by staining
                    (Yan et al., 2013)
                    Cip4 - msl-3
                    two hybrid
                    (Hu et al., 2017.6.13)
                    Cip4 - shi
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Leibfried et al., 2008)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Cip4
                    enhanceable
                    Arp3
                    (Nahm et al., 2010)
                    Cip4
                    enhanceable
                    Cdc42
                    (Nahm et al., 2010)
                    Cip4
                    enhanceable
                    Cdc42|WASp
                    (Nahm et al., 2010)
                    Cip4
                    enhanceable
                    Nost
                    (Zobel et al., 2015)
                    Cip4
                    enhanceable
                    SCAR
                    (Fricke et al., 2009)
                    Cip4
                    suppressible
                    SCAR
                    (Fricke et al., 2009)
                    Cip4
                    suppressible
                    WASp
                    (Fricke et al., 2009)
                    Cip4
                    enhanceable
                    WASp
                    (Nahm et al., 2010)
                    Cip4
                    suppressible
                    wit
                    (Nahm et al., 2010)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Arp3
                    enhanceable
                    Cip4
                    (Nahm et al., 2010)
                    Cdc42
                    enhanceable
                    Cip4
                    (Nahm et al., 2010)
                    Cdc42
                    enhanceable
                    Cip4|WASp
                    (Nahm et al., 2010)
                    RhoGAP92B
                    suppressible
                    Cip4
                    (Nahm et al., 2010)
                    upd1
                    suppressible
                    Cip4
                    (Mukherjee et al., 2006)
                    WASp
                    enhanceable
                    Cdc42|Cip4
                    (Nahm et al., 2010)
                    WASp
                    enhanceable
                    Cip4
                    (Nahm et al., 2010)
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    External Data
                    Linkouts
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3L
                    Recombination map

                    3-12

                    Cytogenetic map
                    64B1-64B2
                    Sequence location
                    3L:4,322,491..4,364,102 [-]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    64B1-64B2
                    Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    3-12

                    (FlyBase, 2016)

                    3-9.5

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (14)
                    Genomic Clones (16)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (118)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     

                    polyclonal

                    (Nahm et al., 2010, Fricke et al., 2009, Leibfried et al., 2008)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of

                    Source for identity of: Cip4 CG15015

                    (Zahedi, 2002.3.25)
                    Source for database merge of

                    Source for merge of: Cip4 CG11341

                    (FlyBase, 1996-)
                    Additional comments

                    Release 1 annotation CG11341 corresponds to part of the release 3.2 annotation for Cip4 (CG15015).

                    (FlyBase, 1996-)
                    Other Comments

                    Cip4 inhibits dia mediated actin filament nucleation and elongation in the presence of chic.

                    (Yan et al., 2013)

                    dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway.

                    (Mukherjee et al., 2006)

                    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

                    (Kiger et al., 2003)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 89 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    modMine - A data warehouse for the modENCODE project
                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                    Linkouts
                    ApoDroso - Functional genomic database for photoreceptor development, survival and function
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                    FlyMine - An integrated database for Drosophila genomics
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (10)
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (82)