FlyBase Gene Report: Dmel\lin-28

Positive Regulators of Insulin-like Receptor Signaling Pathway -: Positive regulators of the Insulin-like Receptor signaling pathway enhance Insulin-like receptor (InR) activation or the activity of intracellular effectors. (Adapted from FBrf0232297, FBrf0230017 and FBrf0229989).

Summary (Interactive Fly)

cold shock and RNA-binding protein - regulator of developmental timing - regulator of microRNA maturation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\lin-28 or the JBrowse view of Dmel\lin-28 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

lin-28-RA

FBtr0077090

NM_139726

1152

195

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

lin-28-PA

FBpp0076798

21.6

195

8.22

NP_647983

AAF50758

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VRN5

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lin-28 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lin-28_1

Linkouts

Gene Ontology (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

mRNA binding

inferred from direct assay

(Chen et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

zinc ion binding

inferred from electronic annotation with InterPro:IPR001878

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

negative regulation of pre-miRNA processing

inferred from mutant phenotype

(Stratoulias et al., 2014)

oogenesis

inferred from mutant phenotype

(Stratoulias et al., 2014)

positive regulation of insulin receptor signaling pathway

inferred from mutant phenotype

(Chen et al., 2015)

inferred from genetic interaction with FLYBASE:InR; FB:FBgn0283499

(Chen et al., 2015)

positive regulation of stem cell proliferation

inferred from mutant phenotype

(Chen et al., 2015)

symmetric stem cell division

inferred from mutant phenotype

(Chen et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

cytosol

inferred from direct assay

(Chen et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 8

ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium