FB2022_03, released June 9, 2022

Gene: Dmel\mad2

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General Information
Symbol
Dmel\mad2
Species
D. melanogaster
Name
mad2
Annotation Symbol
CG17498
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035640
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
64E11-64E12
Sequence location
Recombination map
3-15
RefSeq locus
NT_037436 REGION:5812135..5813093
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:A1Z8P9
(assigned by UniProt )
(Lince-Faria et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in chromosome organization
inferred from mutant phenotype
(Wong et al., 2014)
involved_in male germ-line stem cell asymmetric division
inferred from genetic interaction with FLYBASE:Mtor; FB:FBgn0013756
(Liu et al., 2015)
involved_in mitotic spindle assembly checkpoint signaling
inferred from mutant phenotype
(Orr et al., 2007)
inferred from direct assay
(Logarinho et al., 2004)
inferred from direct assay
(assigned by UniProt )
(Cunha-Silva et al., 2020)
involved_in regulation of mitotic cell cycle spindle assembly checkpoint
inferred from mutant phenotype
(Buffin et al., 2007)
involved_in regulation of mitotic cell cycle
inferred from mutant phenotype
(Lince-Faria et al., 2009)
involved_in regulation of mitotic spindle assembly
inferred from mutant phenotype
(assigned by UniProt )
(Lince-Faria et al., 2009)
inferred from genetic interaction with FLYBASE:SAK; FB:FBgn0026371
(Basto et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in mitotic spindle assembly checkpoint signaling
inferred from biological aspect of ancestor with PANTHER:PTN000217420
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Katsani et al., 2008, Buffin et al., 2005)
located_in kinetochore microtubule
inferred from direct assay
(Buffin et al., 2005)
located_in kinetochore
inferred from direct assay
(Lince-Faria et al., 2009, Katsani et al., 2008, Griffis et al., 2007, Buffin et al., 2005, Logarinho et al., 2004)
inferred from direct assay
(assigned by UniProt )
(Cunha-Silva et al., 2020)
located_in mitotic spindle
inferred from direct assay
(Lince-Faria et al., 2009, Katsani et al., 2008)
located_in nuclear envelope
inferred from direct assay
(Buffin et al., 2005)
located_in nucleoplasm
inferred from direct assay
(Katsani et al., 2008)
located_in nucleus
inferred from direct assay
(Lince-Faria et al., 2009, Logarinho et al., 2004)
located_in spindle matrix
inferred from direct assay
(Lince-Faria et al., 2009)
located_in spindle pole
inferred from direct assay
(Logarinho et al., 2004)
located_in spindle
inferred from direct assay
(Griffis et al., 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000217420
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in kinetochore
inferred from biological aspect of ancestor with PANTHER:PTN000217420
(assigned by GO_Central )
(Gaudet et al., 2011)
is_active_in nucleoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000217420
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
mad2 (mad2) encodes a conserved component of the spindle checkpoint. During mitosis, it is recruited to unattached kinetochores, where it binds the products of Mad1 and fzy, promoting the assembly of the mitotic checkpoint complex. During interphase, the product of mad2 is intranuclear, bound to the product of Mad1, and associated primarily with the nuclear pore complex. [Date last reviewed: 2019-03-14]
Summary (Interactive Fly)

mitotic checkpoint protein that blocks mitotic exit by sequestering Cdc20/Fizzy - required to delay progression through early stages of prometaphase so that cells have time to fully engage the spindle assembly checkpoint

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\mad2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VRQ2)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.43

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mad2-RA
FBtr0077113
NM_139734
818
207
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
mad2-PA
FBpp0076819
23.4
207
5.72
Q9VRQ2
NP_647991
AAF50740
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mad2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
 low
high 
Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
 low
high 
as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
lateral cord neuron
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Katsani et al., 2008, Buffin et al., 2005)
located_in kinetochore microtubule
inferred from direct assay
(Buffin et al., 2005)
located_in kinetochore
inferred from direct assay
(Lince-Faria et al., 2009, Katsani et al., 2008, Griffis et al., 2007, Buffin et al., 2005, Logarinho et al., 2004)
inferred from direct assay
(assigned by UniProt )
(Cunha-Silva et al., 2020)
located_in mitotic spindle
inferred from direct assay
(Lince-Faria et al., 2009, Katsani et al., 2008)
located_in nuclear envelope
inferred from direct assay
(Buffin et al., 2005)
located_in nucleoplasm
inferred from direct assay
(Katsani et al., 2008)
located_in nucleus
inferred from direct assay
(Lince-Faria et al., 2009, Logarinho et al., 2004)
located_in spindle matrix
inferred from direct assay
(Lince-Faria et al., 2009)
located_in spindle pole
inferred from direct assay
(Logarinho et al., 2004)
located_in spindle
inferred from direct assay
(Griffis et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mad2 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mad2
Transgenic constructs containing regulatory region of mad2
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3L)Exel6107
(Ryder, 2004.4.26)
Gene partially disrupted in
Df(3)07084
(Buffin et al., 2007)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\MAD2L1
14 of 15
Yes
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Mad2l1
13 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Mad2l1
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\mad2l1
13 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\mad2l1
10 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\mdf-2
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\MAD2
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\MAD2
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\mad2
11 of 12
Yes
Yes
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
PolZ2
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 2 )
Allele
Disease
Interaction
References
mad2G6595
model of  microcephaly
is exacerbated by cnnHK21
(Buffin et al., 2007)
ameliorates  primary autosomal recessive microcephaly 5
modeled by aspE3
(Buffin et al., 2007)
mad2Δ
ameliorates  primary autosomal recessive microcephaly 5
modeled by aspE3
(Buffin et al., 2007)
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
MAD2L1; mitotic arrest deficient 2 like 1
14 of 15
601467
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      mad2
      suppressible
      cact
      (Liu et al., 2015)
      mad2
      enhanceable
      cnn
      (Rahmani et al., 2009)
      bsk|mad2
      suppressible
      CycB
      (Wong et al., 2014)
      bsk|mad2
      suppressible
      Dark
      (Wong et al., 2014)
      bsk|mad2
      suppressible
      Debcl
      (Wong et al., 2014)
      mad2
      suppressible
      dl
      (Liu et al., 2015)
      bsk|mad2
      suppressible
      hid
      (Wong et al., 2014)
      bsk|mad2
      suppressible
      Myt1
      (Wong et al., 2014)
      mad2
      suppressible
      pll
      (Liu et al., 2015)
      mad2
      suppressible
      spz
      (Liu et al., 2015)
      mad2
      suppressible
      Tl
      (Liu et al., 2015)
      Mps1|mad2
      suppressible
      vtd
      (Althoff et al., 2012)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      asp
      suppressible
      mad2
      (Buffin et al., 2007)
      aurA
      enhanceable
      mad2
      (Caous et al., 2015)
      aurA
      suppressible
      mad2
      (Caous et al., 2015)
      Mps1
      suppressible
      mad2
      (Althoff et al., 2012)
      Mtor
      suppressible
      mad2
      (Liu et al., 2015)
      polo
      suppressible
      mad2
      (Ebrahimi et al., 2010)
      SAK
      enhanceable
      mad2
      (Basto et al., 2008)
      SAK
      suppressible
      mad2
      (Basto et al., 2008)
      Sas-4
      enhanceable
      mad2
      (Poulton et al., 2017, Caous et al., 2015)
      Sas-4
      suppressible
      mad2
      (Caous et al., 2015)
      Tbce
      suppressible
      mad2
      (Métivier et al., 2021)
      Tbce
      enhanceable
      mad2
      (Métivier et al., 2021)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-15
      Cytogenetic map
      64E11-64E12
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      64E11-64E12
      Limits computationally determined from genome sequence between P{PZ}Bre101640 and P{PZ}vn10567
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-15

      (FlyBase, 2016)

      3-14.0

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (8)
      Genomic Clones (20)
      cDNA Clones (16)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Li et al., 2010, Logarinho et al., 2004)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: mad2 CG17498

        (Buffin et al., 2004)
        Source for database merge of
        Additional comments
        Other Comments

        dsRNA has been synthesised against this gene and transfected into S2 cells.

        (Griffis et al., 2007)

        dsRNA against this gene has been used to treat SL2 cells to study the effect of depletion of mad2 on the spindle checkpoint.

        (Muller et al., 2006)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell morphology is aberrant, indicative of a failure in cell cycle/mitosis progression.

        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 44 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (4)
        Reported As
        Symbol Synonym
        CG17498
        (Schertel et al., 2013, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hughes et al., 2008, Buffin et al., 2007, Buffin, 2005, Buffin et al., 2005, Gesellchen et al., 2005, Loop et al., 2004, Stanyon et al., 2004, Asha et al., 2003, Dimova et al., 2003, Kiger et al., 2003, Egger et al., 2002, Anholt and Mackay, 2001)
        MAD2
        (Mendiburo et al., 2011, Garcia et al., 2007)
        Mad2
        (Raich et al., 2018, Défachelles et al., 2015, Défachelles et al., 2015, Rodrigues et al., 2015, Chen et al., 2014, Wong et al., 2014, Cane et al., 2013, Conde et al., 2013, Feijão et al., 2013, Morais da Silva et al., 2013, Batiha and Swan, 2012, Delgehyr et al., 2012, Korenjak et al., 2012, Andrejka et al., 2011, Emre et al., 2011, Orr and Sunkel, 2011, Przewloka et al., 2011, Oliveira et al., 2010, Ding et al., 2009, Lince-Faria et al., 2009, Matos et al., 2009, Williamson et al., 2009, Hickson and O'Farrell, 2008, Katsani et al., 2008, Kwon et al., 2008, Mische et al., 2008, Wen et al., 2008, Griffis et al., 2007, Li et al., 2007, Orr et al., 2007, Pandey et al., 2007, Williams et al., 2007, Logarinho et al., 2004)
        mad2
        (Brás et al., 2021, Chapman et al., 2020, Cunha-Silva et al., 2020, Garrido et al., 2020, Rotelli et al., 2019, Resende et al., 2018, Silva et al., 2018, Poulton et al., 2017, Caous et al., 2015, Ghosh et al., 2015, Gogendeau et al., 2015, Liu et al., 2015, Liu et al., 2015, Venkei and Yamashita, 2015, Bischof and FlyORF project members, 2014.6.20, Liang et al., 2014, Poulton et al., 2014, Rubin et al., 2014, Debruhl et al., 2013, Schertel et al., 2013, Althoff et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Marthiens et al., 2012, Friedman et al., 2011, Neumüller et al., 2011, Ebrahimi et al., 2010, Li et al., 2010, Royou et al., 2010, McCleland et al., 2009, Rahmani et al., 2009, Schittenhelm et al., 2009, Basto et al., 2008, Buffin et al., 2007, Georlette et al., 2007, Hueber et al., 2007, Muller et al., 2006, Karess, 2005)
        Name Synonyms
        mad2
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