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Gene Dmel\mad2

General Information
Symbol	Dmel\mad2	Species	D. melanogaster
Name	mad2	Annotation symbol	CG17498
Feature type	protein_coding_gene	FlyBase ID	FBgn0035640
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64E11-64E12	Sequence location	3L:5,805,235..5,806,183 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mad2 is referred to in FlyBase by the symbol Dmel\mad2 (CG17498, FBgn0035640). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic cell cycle spindle assembly checkpoint; regulation of mitotic prometaphase; mitotic cell cycle checkpoint; cell cycle; regulation of spindle checkpoint. 11 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA-binding HORMA. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1640938_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mad2. Gene sequence location is 3L:5805235..5806183.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features BKN45931 BKN28038 HFA10274
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64E11-64E12   Limits computationally determined from genome sequence between P{PZ}Bre101640 and P{PZ}vn10567
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mad2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mad2-RA FBtr0077113  NM_139734   808   207
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mad2-PA   FBpp0076819   23.4   207   5.72     NP_647991   AAF50740
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • DNA-binding HORMA (IPR003511)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50740   AY070619 AAL48090   BI578221   BI579041   BP556104   CO267385   CO305650   CO305949   CO311258   CZ471089   CZ471256   EC063685   EC067713   EC087665   EC088831   EC203494   EC210515   EC215587   EC225288   EC249748
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VRQ2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035640    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035640 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035640 expression level Developmental Stage   Expression Level embryo 00-02hr    11731 embryo 02-04hr    11104 embryo 04-06hr    10497 embryo 06-08hr    5296 embryo 08-10hr    4819 embryo 10-12hr    2453 embryo 12-14hr    2301 embryo 14-16hr    1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9    1672 white prepupae new    1525 white prepupae 12hr    2871 white prepupae 24hr    2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day    1753 adult male 30day    1669 adult female 01day    2196 adult female 05day    5744 adult female 30day    5784 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11731) embryo 02-04hr  (11104) embryo 04-06hr  (10497) embryo 06-08hr  (5296) embryo 08-10hr  (4819) embryo 10-12hr  (2453) embryo 12-14hr  (2301) embryo 14-16hr  (1802) embryo 16-18hr  (1302) embryo 18-20hr  (628) embryo 20-22hr  (794) embryo 22-24hr  (1293) larva L1  (151) larva L2  (241) larva L3 12hr old  (338) larva L3 puffstage 1-2  (1038) larva L3 puffstage 3-6  (1382) larva L3 puffstage 7-9  (1672) white prepupae new  (1525) white prepupae 12hr  (2871) white prepupae 24hr  (2222) pupae 2d postWPP  (1349) pupae 3d postWPP  (839) pupae 4d postWPP  (735) adult male 01day  (1080) adult male 05day  (1753) adult male 30day  (1669) adult female 01day  (2196) adult female 05day  (5744) adult female 30day  (5784) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11731) embryo 02-04hr  (11104) embryo 04-06hr  (10497) embryo 06-08hr  (5296) embryo 08-10hr  (4819) embryo 10-12hr  (2453) embryo 12-14hr  (2301) embryo 14-16hr  (1802) embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9  (1672) white prepupae new  (1525) white prepupae 12hr  (2871) white prepupae 24hr  (2222) pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day  (1753) adult male 30day  (1669) adult female 01day  (2196) adult female 05day  (5744) adult female 30day  (5784) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11731) embryo 02-04hr  (11104) embryo 04-06hr  10497 embryo 06-08hr    5296 embryo 08-10hr    4819 embryo 10-12hr    2453 embryo 12-14hr    2301 embryo 14-16hr    1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9    1672 white prepupae new    1525 white prepupae 12hr    2871 white prepupae 24hr    2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day    1753 adult male 30day    1669 adult female 01day    2196 adult female 05day    5744 adult female 30day    5784 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11731 embryo 02-04hr    11104 embryo 04-06hr    10497 embryo 06-08hr    5296 embryo 08-10hr    4819 embryo 10-12hr    2453 embryo 12-14hr    2301 embryo 14-16hr    1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9    1672 white prepupae new    1525 white prepupae 12hr    2871 white prepupae 24hr    2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day    1753 adult male 30day    1669 adult female 01day    2196 adult female 05day    5744 adult female 30day    5784 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035640 expression level Developmental Stage   Expression Level embryo 00-02hr    11731 embryo 02-04hr    11104 embryo 04-06hr    10497 embryo 06-08hr    5296 embryo 08-10hr    4819 embryo 10-12hr    2453 embryo 12-14hr    2301 embryo 14-16hr    1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9    1672 white prepupae new    1525 white prepupae 12hr    2871 white prepupae 24hr    2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day    1753 adult male 30day    1669 adult female 01day    2196 adult female 05day    5744 adult female 30day    5784 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11731) embryo 02-04hr  (11104) embryo 04-06hr  (10497) embryo 06-08hr  (5296) embryo 08-10hr  (4819) embryo 10-12hr  (2453) embryo 12-14hr  (2301) embryo 14-16hr  (1802) embryo 16-18hr  (1302) embryo 18-20hr  (628) embryo 20-22hr  (794) embryo 22-24hr  (1293) larva L1  (151) larva L2  (241) larva L3 12hr old  (338) larva L3 puffstage 1-2  (1038) larva L3 puffstage 3-6  (1382) larva L3 puffstage 7-9  (1672) white prepupae new  (1525) white prepupae 12hr  (2871) white prepupae 24hr  (2222) pupae 2d postWPP  (1349) pupae 3d postWPP  (839) pupae 4d postWPP  (735) adult male 01day  (1080) adult male 05day  (1753) adult male 30day  (1669) adult female 01day  (2196) adult female 05day  (5744) adult female 30day  (5784) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11731) embryo 02-04hr  (11104) embryo 04-06hr  (10497) embryo 06-08hr  (5296) embryo 08-10hr  (4819) embryo 10-12hr  2453 embryo 12-14hr  2301 embryo 14-16hr  1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9  1672 white prepupae new  1525 white prepupae 12hr  (2871) white prepupae 24hr  2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day  1753 adult male 30day  1669 adult female 01day  2196 adult female 05day  (5744) adult female 30day  (5784) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11731 embryo 02-04hr  11104 embryo 04-06hr  10497 embryo 06-08hr    5296 embryo 08-10hr    4819 embryo 10-12hr    2453 embryo 12-14hr    2301 embryo 14-16hr    1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9    1672 white prepupae new    1525 white prepupae 12hr    2871 white prepupae 24hr    2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day    1753 adult male 30day    1669 adult female 01day    2196 adult female 05day    5744 adult female 30day    5784 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11731 embryo 02-04hr    11104 embryo 04-06hr    10497 embryo 06-08hr    5296 embryo 08-10hr    4819 embryo 10-12hr    2453 embryo 12-14hr    2301 embryo 14-16hr    1802 embryo 16-18hr    1302 embryo 18-20hr    628 embryo 20-22hr    794 embryo 22-24hr    1293 larva L1    151 larva L2    241 larva L3 12hr old    338 larva L3 puffstage 1-2    1038 larva L3 puffstage 3-6    1382 larva L3 puffstage 7-9    1672 white prepupae new    1525 white prepupae 12hr    2871 white prepupae 24hr    2222 pupae 2d postWPP    1349 pupae 3d postWPP    839 pupae 4d postWPP    735 adult male 01day    1080 adult male 05day    1753 adult male 30day    1669 adult female 01day    2196 adult female 05day    5744 adult female 30day    5784 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035640    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035640 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035640 expression level Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  (672.2) Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035640 expression level Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary  672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    391.9 Larval Midgut    24.5 Larval Hindgut    30.9 Larval Malpighian Tubules    18.7 Larval Fat Body    52.5 Larval Salivary Gland    16.9 Larval Trachea    100.05 Larval Carcass    43.45 Adult Head no informative data Adult Eye no informative data Adult Brain    8.8 Adult Thoracic-Abdominal Ganglion    24.6 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    672.2 Adult Testis    251.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    8.8   391.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    24.6   NA  Crop    no informative data   24.5  Midgut    no informative data   30.9  Hindgut    no informative data   18.7  Malpighian Tubules    no informative data   52.5  Fat Body    no informative data   16.9  Salivary Gland    no informative data   NA  Heart    no informative data   100.05  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    672.2   NA  Testis    251.2   NA  Male Accessory Gland    no informative data   43.45  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035640 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17498-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mad2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 mad2GD9396 viable mad2G6595 mad2Δ viable, with Scer\GAL4pnr-MD237 mad2GD9396 Sterility Allele fertile mad2G6595 mad2Δ Other Phenotypes Allele cell cycle defective mad2G6595 mad2Δ mitotic cell cycle defective mad2G6595 mad2Δ Phenotype manifest in Allele embryonic/larval brain | larval stage, with Scer\GAL41407 mad2GD9396
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of mad2 Class Mutagen Stocks Known lesion mad2c06928 piggyBac transposase 1 -- mad2c07120 piggyBac transposase 1 -- mad2EY21687 P-element activity 1 -- mad2G6595 0 Yes mad2P 0 -- mad2Δ P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mad2 Class Mutagen Stocks Known lesion mad2GD16427 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mad2GD9396 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mad2KK108038 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mad2T:Avic\GFP-S65T in vitro construct - coding region fusion 1 Yes mad2Ubi-p63E.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6107 (Ryder, 2004.4.26)
Partially disrupted in	Df(3)07084 (Buffin et al., 2007)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9396} NA P{GD16427} NA P{KK108038} NA characterization construct P{Ubi-GFP-Mad2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}mad2c06928 NA PBac{PB}mad2c07120 NA insertion of mobile activating element P{EP}mad2G6595 NA P{EPgy2}mad2EY21687 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell cycle inferred from mutant phenotype (Kiger et al., 2003) mitotic cell cycle checkpoint inferred from mutant phenotype (Buffin et al., 2004) mitotic cell cycle spindle assembly checkpoint inferred from direct assay (Logarinho et al., 2004) inferred from mutant phenotype (Orr et al., 2007) regulation of mitotic prometaphase inferred from mutant phenotype (Buffin et al., 2007) regulation of spindle checkpoint inferred from mutant phenotype (Buffin et al., 2007)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Buffin et al., 2005) kinetochore inferred from direct assay (Buffin et al., 2005, Griffis et al., 2007) kinetochore microtubule inferred from direct assay (Buffin et al., 2005) microtubule associated complex inferred from direct assay (Hughes et al., 2008) nuclear envelope inferred from direct assay (Buffin et al., 2005) spindle inferred from direct assay (Griffis et al., 2007)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic cell cycle spindle assembly checkpoint inferred from sequence or structural similarity with Saccharomyces MAD2 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with Saccharomyces MAD2 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mad2 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64116 DroID - A comprehensive database of gene and protein interactions. • FBgn0035640 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38656
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10441 Dere\GG14107 Dgri\GH17035 Dmoj\GI12039 Dper\GL21408 Dpse\GA14530 Dsec\GM13893 Dsim\GD15958 Dvir\GJ13309 Dwil\GK17532 Dyak\GE20532
Curated drosophilid orthologs	Dpse\GA14530
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008316-PA Aedes aegypti (mosquito) AGAP000751-PA Anopheles gambiae (mosquito) XP_393696.2 Apis mellifera (honey bee) XP_001949898.1 Acyrthosiphon pisum (pea aphid) At3g25980.1 Arabidopsis thaliana (wall cress) 87034 Batrachochytrium dendrobatidis (chytrid fungus) 260671 Branchiostoma floridae (lancelet) BGIBMGA012734-PA Bombyx mori (silk worm) ENSBTAP00000046657 Bos taurus (bovine) CAL0001147 Candida albicans (a form of yeast) CN09138 Caenorhabditis brenneri (small nematode) CBP03391 Caenorhabditis briggsae (nematode) CE26559 Caenorhabditis elegans (worm) ENSCAFP00000024226 Canis familiaris (dog) CAGL0J01089g Candida glabrata (haploid yeast) JA05261 Caenorhabditis japonica (nematode) CMS347C Cyanidioschyzon merolae (red alga) cn03582 Cryptococcus neoformans (yeast-like fungus) CPIJ008480 Culex pipens (mosquito) ENSCPOP00000008256 Cavia porcellus (guinea pig) 130117 Chlamidomonas reinhardtii (green alga) RP39558 Caenorhabditis remanei (nematode) ENSCSAVP00000015821 Ciona savignyi (sedentary tunicate) 166738 Capitella spl (polychaete worm) DDB0217277 Dictyostelium discoideum (amoeba) DDB0232272 Dictyostelium discoideum (amoeba) DEHA2D16412g Debaryomyces Hansenii (yeast) 299824 Daphnia pulex (daphnia) ENSDARP00000003616 Danio rerio (zebra fish) ENSECAP00000011348 Equus caballus (horse) ENSGACP00000002087 Gymnopilus aculeatus (mushroom) ENSGALP00000019493 Gallus gallus (chicken) GL50803_100955 Giardia lamblia (flagellated protozoan) 68763 Hypsipyla robusta (cedar shoot borer) ENSP00000296509 Homo sapiens (human) ISCW001444-PA Ixodes scapularis (deer tick) KLLA0D09438g Kluyveromyces lactis (yeast) 182926 Lottia gigantea (owl limpet) LmjF25.1670 Leishmania major (virus) 27575 Monocosta brevicollis (choanoflagellate) ENSMODP00000023636 Monodelphis domestica (gray opossum) ENSMMUP00000006482 Macaca mulatta (rhesus monkey) ENSMUSP00000112304 Mus musculus (house mouse) 235892 Nematostella vectensis (starlet anemone) XP_001599142.1 Nasonia vitripennis (wasp) ENSOANP00000009904 Ornithorynchus anatinus (platypus) ENSORLP00000025740 Oryzias latipes (japanese killifish) LOC_Os04g40940.1 Oryza sativa (asian rice) 6878 Ostreococcus tauri (green alga) PHUM000270-PA Pediculus humanus (human body louse) PP27988 Pristionchus pacificus (nematode) 194582 Physcomitrella patens (moss) ENSPPYP00000016788 Pongo pygmaeus (orangutan) 93838 Phytophthora ramorum (sudden oak death pathogen) 127531 Phytophthora sojae (root rot pathogen) 720923 Populus trichocarpa (black cottonwood) ENSPTRP00000028167 Pan troglodytes (chimpanzee) ENSRNOP00000007285 Rattus norvegicus (norway rat) 4829894 Sorghum bicolor (sorghum) YJL030W Saccharomyces cerevisiae (budding yeast) Smp_056350 Schistosoma mansoni (trematode parasite) SPBC20F10.06 Schizosaccharomyces pombe (fission yeast) XP_001178696.1 Strongylocentrotus purpuratus (purple sea urchin) 23206 Trichoplax adhaerens (metazoa) XP_967746.1 Tribolium castaneum (red flour beetle) Tc00.1047053510091.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510421.290 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009075 Tetraodon nigroviridis (green spotted pufferfish) 7890 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025937 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004490 Xenopus tropicalis (frog) YALI0E13684g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16786 NV16131 LH13699 ISCW001444 FBgn0237845 FBgn0219531 FBgn0200535 FBgn0187606 FBgn0168824 FBgn0074558 FBgn0159001 FBgn0134796 FBgn0124506 FBgn0106369 FBgn0087482 CPIJ008480 BGIBMGA012734 ACYPI004152 GB12183 AGAP000751 AAEL008316 PHUM392720 GLEAN_13206
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	35820 w*; Nup107E8; P{mad2.GFP}9a, P{mRFP-Nup107.K}7.1 22495 y1 w67c23; P{EPgy2}mad2EY21687/TM3, Sb1 Ser1
Harvard	- PBac{PB}mad2c06928 - PBac{PB}mad2c07120
VDRC	v106003 P{KK108038}VIE-260B v47918 w1118; P{GD16427}v47918 v47919 w1118; P{GD16427}v47919 v25262 w1118; P{GD9396}v25262/CyO v25264 w1118; P{GD9396}v25264/CyO
Genomic Clones ( 2 )
	BACR11A21 BACR29P05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE72064
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE73013
Other clones	37517 72576 101450 102312 146242 147048 159850 166179 273781 EK150010 EK223932 EK249159 EK249853 FGM301D09
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035640 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38656
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mad2 CG17498 (Buffin et al., 2004)
Source for database merge of
Additional comments
Other Comments
	dsRNA has been synthesised against this gene and transfected into S2 cells. (Griffis et al., 2007) dsRNA against this gene has been used to treat SL2 cells to study the effect of depletion of mad2 on the spindle checkpoint. (Muller et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: cell morphology is aberrant, indicative of a failure in cell cycle/mitosis progression. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139734 RefSeq (Proteins) • NP_647991 DDBJ / EMBL / GenBank • AAF50740 AAL48090 AY070619 BI578221 CZ471089 CZ471256 Entrez Gene - A searchable database of RefSeq genes. • 38656 UniProtKB/TrEMBL • Q9VRQ2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • DNA-binding HORMA (IPR003511)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64116 DroID - A comprehensive database of gene and protein interactions. • FBgn0035640 DRSC - Results from RNAi screens. • FBgn0035640 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035640 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17498-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035640 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38656 InParanoid A subset of ortholog calls from InParanoid. • AAEL008316-PA Aedes aegypti (mosquito) AGAP000751-PA Anopheles gambiae (mosquito) XP_393696.2 Apis mellifera (honey bee) XP_001949898.1 Acyrthosiphon pisum (pea aphid) At3g25980.1 Arabidopsis thaliana (wall cress) 87034 Batrachochytrium dendrobatidis (chytrid fungus) 260671 Branchiostoma floridae (lancelet) BGIBMGA012734-PA Bombyx mori (silk worm) ENSBTAP00000046657 Bos taurus (bovine) CAL0001147 Candida albicans (a form of yeast) CN09138 Caenorhabditis brenneri (small nematode) CBP03391 Caenorhabditis briggsae (nematode) CE26559 Caenorhabditis elegans (worm) ENSCAFP00000024226 Canis familiaris (dog) CAGL0J01089g Candida glabrata (haploid yeast) JA05261 Caenorhabditis japonica (nematode) CMS347C Cyanidioschyzon merolae (red alga) cn03582 Cryptococcus neoformans (yeast-like fungus) CPIJ008480 Culex pipens (mosquito) ENSCPOP00000008256 Cavia porcellus (guinea pig) 130117 Chlamidomonas reinhardtii (green alga) RP39558 Caenorhabditis remanei (nematode) ENSCSAVP00000015821 Ciona savignyi (sedentary tunicate) 166738 Capitella spl (polychaete worm) DDB0217277 Dictyostelium discoideum (amoeba) DDB0232272 Dictyostelium discoideum (amoeba) DEHA2D16412g Debaryomyces Hansenii (yeast) 299824 Daphnia pulex (daphnia) ENSDARP00000003616 Danio rerio (zebra fish) ENSECAP00000011348 Equus caballus (horse) ENSGACP00000002087 Gymnopilus aculeatus (mushroom) ENSGALP00000019493 Gallus gallus (chicken) GL50803_100955 Giardia lamblia (flagellated protozoan) 68763 Hypsipyla robusta (cedar shoot borer) ENSP00000296509 Homo sapiens (human) ISCW001444-PA Ixodes scapularis (deer tick) KLLA0D09438g Kluyveromyces lactis (yeast) 182926 Lottia gigantea (owl limpet) LmjF25.1670 Leishmania major (virus) 27575 Monocosta brevicollis (choanoflagellate) ENSMODP00000023636 Monodelphis domestica (gray opossum) ENSMMUP00000006482 Macaca mulatta (rhesus monkey) ENSMUSP00000112304 Mus musculus (house mouse) 235892 Nematostella vectensis (starlet anemone) XP_001599142.1 Nasonia vitripennis (wasp) ENSOANP00000009904 Ornithorynchus anatinus (platypus) ENSORLP00000025740 Oryzias latipes (japanese killifish) LOC_Os04g40940.1 Oryza sativa (asian rice) 6878 Ostreococcus tauri (green alga) PHUM000270-PA Pediculus humanus (human body louse) PP27988 Pristionchus pacificus (nematode) 194582 Physcomitrella patens (moss) ENSPPYP00000016788 Pongo pygmaeus (orangutan) 93838 Phytophthora ramorum (sudden oak death pathogen) 127531 Phytophthora sojae (root rot pathogen) 720923 Populus trichocarpa (black cottonwood) ENSPTRP00000028167 Pan troglodytes (chimpanzee) ENSRNOP00000007285 Rattus norvegicus (norway rat) 4829894 Sorghum bicolor (sorghum) YJL030W Saccharomyces cerevisiae (budding yeast) Smp_056350 Schistosoma mansoni (trematode parasite) SPBC20F10.06 Schizosaccharomyces pombe (fission yeast) XP_001178696.1 Strongylocentrotus purpuratus (purple sea urchin) 23206 Trichoplax adhaerens (metazoa) XP_967746.1 Tribolium castaneum (red flour beetle) Tc00.1047053510091.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053510421.290 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009075 Tetraodon nigroviridis (green spotted pufferfish) 7890 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025937 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000004490 Xenopus tropicalis (frog) YALI0E13684g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/mad2.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38656 modMine - Data generated by the modENCODE project. • FBgn0035640 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16786 NV16131 LH13699 ISCW001444 FBgn0237845 FBgn0219531 FBgn0200535 FBgn0187606 FBgn0168824 FBgn0074558 FBgn0159001 FBgn0134796 FBgn0124506 FBgn0106369 FBgn0087482 CPIJ008480 BGIBMGA012734 ACYPI004152 GB12183 AGAP000751 AAEL008316 PHUM392720 GLEAN_13206
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG17498 (Buffin, 2005, Buffin et al., 2005, Kiger et al., 2003, Egger et al., 2002, Dimova et al., 2003, Asha et al., 2003, Anholt and Mackay, 2001, Buffin et al., 2007, Keleman et al., 2009.8.5, Hughes et al., 2008) mad2 (Muller et al., 2006, Karess, 2005, Hueber et al., 2007, Georlette et al., 2007, Basto et al., 2008, Buffin et al., 2007, McCleland et al., 2009, Rahmani et al., 2009, Schittenhelm et al., 2009, Royou et al., 2010, Li et al., 2010, Ebrahimi et al., 2010, Neumüller et al., 2011) Mad2 (Logarinho et al., 2004, Li et al., 2007, Griffis et al., 2007, Hickson and O'Farrell, 2008, Orr et al., 2007, Wen et al., 2008, Kwon et al., 2008, Pandey et al., 2007, Williams et al., 2007, Katsani et al., 2008, Lince-Faria et al., 2009, Mische et al., 2008, Ding et al., 2009, Matos et al., 2009, Oliveira et al., 2010, Przewloka et al., 2011) MAD2 (Garcia et al., 2007)
Name Synonym	mad2
Secondary FlyBase IDs
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) Conference report  ( 1 ) Computer file  ( 3 ) Curated genome annotation  ( 1 )
Recent research papers ( 7 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Przewloka et al., 2011, Curr. Biol. 21(5): 399--405 CENP-C Is a Structural Platform for Kinetochore Assembly. [FBrf0213151] Ebrahimi et al., 2010, J. Biol. Chem. 285(37): 28667--28673 Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex. [FBrf0214097] Li et al., 2010, Mol. Cell. Biol. 30(13): 3384--3395 Recruitment of Cdc20 to the kinetochore requires BubR1 but not Mad2 in Drosophila melanogaster. [FBrf0210988] Meisel et al., 2010, Mol. Biol. Evol. 27(8): 1963--1978 Adaptive Evolution of Genes Duplicated from the Drosophila pseudoobscura neo-X Chromosome. [FBrf0211330] Oliveira et al., 2010, Nat. Cell Biol. 12(2): 185--192 Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. [FBrf0209876] Royou et al., 2010, Cell 140(2): 235--245 BubR1- and Polo-Coated DNA Tethers Facilitate Poleward Segregation of Acentric Chromatids. [FBrf0209924] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...