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Gene Dmel\Jon65Aiii

General Information
Symbol	Dmel\Jon65Aiii	Species	D. melanogaster
Name	Jonah 65Aiii	Annotation symbol	CG6483
Feature type	protein_coding_gene	FlyBase ID	FBgn0035665
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	Jon65A
Genomic Location
Chromosome (arm)	3L	Recombination map	3-[20]
Cytogenetic map	65A3-65A3	Sequence location	3L:6,043,857..6,044,790 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Jonah 65Aiii is referred to in FlyBase by the symbol Dmel\Jon65Aiii (CG6483, FBgn0035665). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase activity. It is reported to be involved in the biological process: proteolysis. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase S1; Peptidase S1, trypsin family, active site; Peptidase S1A, chymotrypsin-type; Trypsin-like cysteine/serine peptidase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during late larval stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut. Comments on Affy2 ProbeSet: ProbeSet 1626093_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Jon65Aiii. Gene sequence location is 3L:6043857..6044790.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65A3-65A3   Limits computationally determined from genome sequence between P{PZ}vn10567 and P{PZ}loj04026
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65A-65A   (determined by in situ hybridisation)   (Carlson and Hogness, 1985)
Experimentally Determined Recombination Data
Location	3-[20] (Lindsley and Zimm, 1992)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Jon65Aiii for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Jon65Aiii-RA FBtr0077041  NM_139756   875   274
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Jon65Aiii-PA   FBpp0076749   28.5   274   7.30     NP_648013   AAF50713
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1, trypsin family, active site (IPR018114) Peptidase S1 (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Trypsin-like cysteine/serine peptidase domain (IPR009003)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50713   AI062337   AI109520   AI113674   AI135145   AI238283   AI238561   AI257146   AI258122   AI258632   AI259068   AI259277   AI259687   AI260124   AI260148   AI260506   AI260702   AI293487   AI294206   AI294377   AI294478   AI294749   AI295016   AI295131   AI295262   AI295345   AI296514   AI297799   AI387144   AI388272   AI388330   AI403283   AI405139   AW940050   AX154710   AY095514 AAM12248   BG632319   BG639453   BI163512   BI228576   BI369099   BI371071   BI486180   BQ103009   CK131602   CK131612   CK131874   CK131884   CK132187   CK132418   CK657447   CK657997   CK658093   CK658430   CK658869   CK659196   CK659212   CK659607   CK659674   CK659718   CK660068   CK660254   CK660429   CK662451   CO179780   CO179823   CO179825   CO180429   CO184380   CO191162   CO192819   CO193333   CO195870   CO273032   CO274356   CO293958   CO296164   CO298321   CO302529   CO325162   CO329420   EC051049   EC051149   EC053172   EC053646   EC054152   EC054352   EC055592   EC055616   EC055877   EC056325   EC056415   EC083330   EC211436   EC212260   EC212712   EC216181   EC220927   EL872516   EL872753   EL876207   EL876354   EL878487   EL878908   EL879852   EL879982   EL880240   EL880323   EL880422   EL880503   EV575527   EV577387   EV578268   EV585229   EV585995   EV586312   EV586433   EV586776   EV587497   EV592092   EV593135   EV596174   EV598132   EV599113   GH750380   GH751263   GH754228   GH754324   GH754633   GH757592   GH757637   GH760466   GH774639   GH775115   GH776628   GH777881   GH778214   GH782862   GH784391   GH789545   GH803217   GH803971   GH804986   GH809694   GH811057   GH816709   GH817346   GH817499   GH822473   GH823820   GH826068   GH827207   GH827921   GH830069   GH841675   GH843074   GH850179   GH850899   GH854592   GH855564   GH856844   GH857923   GH860201   GH862798   GH863175   GH863765   GH871489   GH871992   GH876828   GH878862   GH883399   GH884706   GH885763   GH891866   GH895166   GH897627   GH898897   GH912349   GH913391   GH913877   GH914517   GH914882   GH916751   GH923398   GH924680   GH934944   GH936869   GH939357   GH940173   GH940264   X65275
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VRS7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 13 -- 16   embryonic midgut chamber   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut. Expression at moderate levels in the following post-embryonic organs or tissues: adult hindgut. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut    5348.8 Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut    6715.8 Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut  (5348.8) Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut  (6715.8) Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut  (5348.8) Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut  (6715.8) Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut    5348.8 Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut    6715.8 Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut    5348.8 Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut    6715.8 Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut  (5348.8) Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut  (6715.8) Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut  (5348.8) Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut  (6715.8) Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    5.35 Larval Midgut    5348.8 Larval Hindgut    56.2 Larval Malpighian Tubules    7.2 Larval Fat Body    375.9 Larval Salivary Gland    13.5 Larval Trachea    354.075 Larval Carcass    15.7 Adult Head    88.3 Adult Eye    53.325 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    8 Adult Crop    71.5 Adult Midgut    6715.8 Adult Hindgut    462.8 Adult Malpighian Tubules    4.8 Adult Fat Body    10.5 Adult Salivary Gland    16.2 Adult Heart    10.525 Adult VirginFemale Spermatheca    6.8 Adult InseminatedFemale Spermatheca    19.7 Adult Ovary    1.3 Adult Testis    18.8 Adult Male Accessory Gland    7 Adult Carcass    110.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    1.9   5.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    8   NA  Crop    no informative data   5348.8  Midgut    6715.8   no informative data  Hindgut    462.8   7.2  Malpighian Tubules    4.8   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    6.8   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    1.3   NA  Testis    no informative data   NA  Male Accessory Gland    7   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    526 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    174 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7623 digestive system, 1-day adult    5904 digestive system, 4-day adult    5510 digestive system, 20-day adult    7811 fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering    49 carcass, 1-day adult    120 carcass, 4-day adult    108 carcass, 20-day adult    243 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    26 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (526) central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (174) salivary gland, white prepupae    8 digestive system, larvae L3 wandering  (7623) digestive system, 1-day adult  (5904) digestive system, 4-day adult  (5510) digestive system, 20-day adult  (7811) fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering  (49) carcass, 1-day adult  (120) carcass, 4-day adult  (108) carcass, 20-day adult  (243) ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male  26 accessory gland, mated 4-day male  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (526) central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (174) salivary gland, white prepupae    8 digestive system, larvae L3 wandering  (7623) digestive system, 1-day adult  (5904) digestive system, 4-day adult  (5510) digestive system, 20-day adult  (7811) fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering    49 carcass, 1-day adult  (120) carcass, 4-day adult  (108) carcass, 20-day adult  (243) ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    26 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    526 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    174 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7623 digestive system, 1-day adult    5904 digestive system, 4-day adult    5510 digestive system, 20-day adult    7811 fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering    49 carcass, 1-day adult    120 carcass, 4-day adult    108 carcass, 20-day adult    243 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    26 accessory gland, mated 4-day male    56 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    526 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    174 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7623 digestive system, 1-day adult    5904 digestive system, 4-day adult    5510 digestive system, 20-day adult    7811 fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering    49 carcass, 1-day adult    120 carcass, 4-day adult    108 carcass, 20-day adult    243 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    26 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (526) central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (174) salivary gland, white prepupae    8 digestive system, larvae L3 wandering  (7623) digestive system, 1-day adult  (5904) digestive system, 4-day adult  (5510) digestive system, 20-day adult  (7811) fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering  (49) carcass, 1-day adult  (120) carcass, 4-day adult  (108) carcass, 20-day adult  (243) ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male  26 accessory gland, mated 4-day male  (56) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (526) central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering  (174) salivary gland, white prepupae    8 digestive system, larvae L3 wandering  (7623) digestive system, 1-day adult  (5904) digestive system, 4-day adult  (5510) digestive system, 20-day adult  (7811) fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering    49 carcass, 1-day adult  120 carcass, 4-day adult  108 carcass, 20-day adult  (243) ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    26 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    526 central nervous system, larvae L3    9 central nervous system, pupae P8    1 head, virgin 1-day female    9 head, virgin 4-day female    0 head, virgin 20-day female    2 head, mated 1-day female    3 head, mated 4-day female    0 head, mated 20-day female    13 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    174 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    7623 digestive system, 1-day adult    5904 digestive system, 4-day adult    5510 digestive system, 20-day adult    7811 fat body, larvae L3 wandering    3 fat body, white prepupae    22 fat body, pupae P8    14 carcass, larvae L3 wandering    49 carcass, 1-day adult    120 carcass, 4-day adult    108 carcass, 20-day adult    243 ovary, virgin 4-day female    1 ovary, mated 4-day female    2 testis, mated 4-day male    26 accessory gland, mated 4-day male    56 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during late larval stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr    46 embryo 18-20hr    69 embryo 20-22hr    192 embryo 22-24hr    165 larva L1    794 larva L2    1283 larva L3 12hr old    892 larva L3 puffstage 1-2    5174 larva L3 puffstage 3-6    3282 larva L3 puffstage 7-9    1610 white prepupae new    632 white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    32 adult male 01day    1281 adult male 05day    1777 adult male 30day    1659 adult female 01day    2666 adult female 05day    1819 adult female 30day    1980 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr  (46) embryo 18-20hr  (69) embryo 20-22hr  (192) embryo 22-24hr  (165) larva L1  (794) larva L2  (1283) larva L3 12hr old  (892) larva L3 puffstage 1-2  (5174) larva L3 puffstage 3-6  (3282) larva L3 puffstage 7-9  (1610) white prepupae new  (632) white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP  (32) adult male 01day  (1281) adult male 05day  (1777) adult male 30day  (1659) adult female 01day  (2666) adult female 05day  (1819) adult female 30day  (1980) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr    46 embryo 18-20hr    69 embryo 20-22hr  (192) embryo 22-24hr  (165) larva L1  (794) larva L2  (1283) larva L3 12hr old  (892) larva L3 puffstage 1-2  (5174) larva L3 puffstage 3-6  (3282) larva L3 puffstage 7-9  (1610) white prepupae new  (632) white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    32 adult male 01day  (1281) adult male 05day  (1777) adult male 30day  (1659) adult female 01day  (2666) adult female 05day  (1819) adult female 30day  (1980) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr    46 embryo 18-20hr    69 embryo 20-22hr    192 embryo 22-24hr    165 larva L1    794 larva L2    1283 larva L3 12hr old    892 larva L3 puffstage 1-2    5174 larva L3 puffstage 3-6    3282 larva L3 puffstage 7-9    1610 white prepupae new    632 white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    32 adult male 01day    1281 adult male 05day    1777 adult male 30day    1659 adult female 01day    2666 adult female 05day    1819 adult female 30day    1980 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr    46 embryo 18-20hr    69 embryo 20-22hr    192 embryo 22-24hr    165 larva L1    794 larva L2    1283 larva L3 12hr old    892 larva L3 puffstage 1-2    5174 larva L3 puffstage 3-6    3282 larva L3 puffstage 7-9    1610 white prepupae new    632 white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    32 adult male 01day    1281 adult male 05day    1777 adult male 30day    1659 adult female 01day    2666 adult female 05day    1819 adult female 30day    1980 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr  (46) embryo 18-20hr  (69) embryo 20-22hr  (192) embryo 22-24hr  (165) larva L1  (794) larva L2  (1283) larva L3 12hr old  (892) larva L3 puffstage 1-2  (5174) larva L3 puffstage 3-6  (3282) larva L3 puffstage 7-9  (1610) white prepupae new  (632) white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP  32 adult male 01day  (1281) adult male 05day  (1777) adult male 30day  (1659) adult female 01day  (2666) adult female 05day  (1819) adult female 30day  (1980) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr    46 embryo 18-20hr    69 embryo 20-22hr  (192) embryo 22-24hr  (165) larva L1  (794) larva L2  (1283) larva L3 12hr old  (892) larva L3 puffstage 1-2  (5174) larva L3 puffstage 3-6  (3282) larva L3 puffstage 7-9  (1610) white prepupae new  (632) white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    32 adult male 01day  (1281) adult male 05day  (1777) adult male 30day  (1659) adult female 01day  (2666) adult female 05day  (1819) adult female 30day  (1980) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    1 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    14 embryo 16-18hr    46 embryo 18-20hr    69 embryo 20-22hr    192 embryo 22-24hr    165 larva L1    794 larva L2    1283 larva L3 12hr old    892 larva L3 puffstage 1-2    5174 larva L3 puffstage 3-6    3282 larva L3 puffstage 7-9    1610 white prepupae new    632 white prepupae 12hr    3 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    32 adult male 01day    1281 adult male 05day    1777 adult male 30day    1659 adult female 01day    2666 adult female 05day    1819 adult female 30day    1980 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1343 cold shock, 4-day adult    1748 heat shock, 4-day adult    1871 Cadmium 50 mM 6 hrs, larvae L3    2881 Cadmium 50 mM 12 hrs, larvae L3    2509 Cadmium 50 mM 48 hrs, 4-day adult    1977 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    1476 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    2149 Zinc 4.5 mM 48 hrs, 4-day adult    601 Ethanol 2.5% 3 hrs, larvae L3    290 Ethanol 5% 3 hrs, larvae L3    2308 Ethanol 10% 3 hrs, larvae L3    3173 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2947 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    200 Caffeine 25 mg/ml 48 hrs, 4-day adult    1295 Paraquat 5 mM 48 hrs, 4-day adult    535 Paraquat 10 mM 48 hrs, 4-day adult    718 Rotenone 2 μg 12 hrs, larvae L3    3088 Rotenone 8 μg 12 hrs, larvae L3    3110 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (1343) cold shock, 4-day adult  (1748) heat shock, 4-day adult  (1871) Cadmium 50 mM 6 hrs, larvae L3  (2881) Cadmium 50 mM 12 hrs, larvae L3  (2509) Cadmium 50 mM 48 hrs, 4-day adult  (1977) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3  (1476) Copper 15 mM 48 hrs, 4-day adult  (142) Zinc 5 mM 12 hrs, larvae L3  (2149) Zinc 4.5 mM 48 hrs, 4-day adult  (601) Ethanol 2.5% 3 hrs, larvae L3  (290) Ethanol 5% 3 hrs, larvae L3  (2308) Ethanol 10% 3 hrs, larvae L3  (3173) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2947) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (200) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1295) Paraquat 5 mM 48 hrs, 4-day adult  (535) Paraquat 10 mM 48 hrs, 4-day adult  (718) Rotenone 2 μg 12 hrs, larvae L3  (3088) Rotenone 8 μg 12 hrs, larvae L3  (3110) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (1343) cold shock, 4-day adult  (1748) heat shock, 4-day adult  (1871) Cadmium 50 mM 6 hrs, larvae L3  (2881) Cadmium 50 mM 12 hrs, larvae L3  (2509) Cadmium 50 mM 48 hrs, 4-day adult  (1977) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3  (1476) Copper 15 mM 48 hrs, 4-day adult  (142) Zinc 5 mM 12 hrs, larvae L3  (2149) Zinc 4.5 mM 48 hrs, 4-day adult  (601) Ethanol 2.5% 3 hrs, larvae L3  (290) Ethanol 5% 3 hrs, larvae L3  (2308) Ethanol 10% 3 hrs, larvae L3  (3173) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2947) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (200) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1295) Paraquat 5 mM 48 hrs, 4-day adult  (535) Paraquat 10 mM 48 hrs, 4-day adult  (718) Rotenone 2 μg 12 hrs, larvae L3  (3088) Rotenone 8 μg 12 hrs, larvae L3  (3110) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1343 cold shock, 4-day adult    1748 heat shock, 4-day adult    1871 Cadmium 50 mM 6 hrs, larvae L3    2881 Cadmium 50 mM 12 hrs, larvae L3    2509 Cadmium 50 mM 48 hrs, 4-day adult    1977 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    1476 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    2149 Zinc 4.5 mM 48 hrs, 4-day adult    601 Ethanol 2.5% 3 hrs, larvae L3    290 Ethanol 5% 3 hrs, larvae L3    2308 Ethanol 10% 3 hrs, larvae L3    3173 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2947 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    200 Caffeine 25 mg/ml 48 hrs, 4-day adult    1295 Paraquat 5 mM 48 hrs, 4-day adult    535 Paraquat 10 mM 48 hrs, 4-day adult    718 Rotenone 2 μg 12 hrs, larvae L3    3088 Rotenone 8 μg 12 hrs, larvae L3    3110 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1343 cold shock, 4-day adult    1748 heat shock, 4-day adult    1871 Cadmium 50 mM 6 hrs, larvae L3    2881 Cadmium 50 mM 12 hrs, larvae L3    2509 Cadmium 50 mM 48 hrs, 4-day adult    1977 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    1476 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    2149 Zinc 4.5 mM 48 hrs, 4-day adult    601 Ethanol 2.5% 3 hrs, larvae L3    290 Ethanol 5% 3 hrs, larvae L3    2308 Ethanol 10% 3 hrs, larvae L3    3173 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2947 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    200 Caffeine 25 mg/ml 48 hrs, 4-day adult    1295 Paraquat 5 mM 48 hrs, 4-day adult    535 Paraquat 10 mM 48 hrs, 4-day adult    718 Rotenone 2 μg 12 hrs, larvae L3    3088 Rotenone 8 μg 12 hrs, larvae L3    3110 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (1343) cold shock, 4-day adult  (1748) heat shock, 4-day adult  (1871) Cadmium 50 mM 6 hrs, larvae L3  (2881) Cadmium 50 mM 12 hrs, larvae L3  (2509) Cadmium 50 mM 48 hrs, 4-day adult  (1977) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3  (1476) Copper 15 mM 48 hrs, 4-day adult  (142) Zinc 5 mM 12 hrs, larvae L3  (2149) Zinc 4.5 mM 48 hrs, 4-day adult  (601) Ethanol 2.5% 3 hrs, larvae L3  (290) Ethanol 5% 3 hrs, larvae L3  (2308) Ethanol 10% 3 hrs, larvae L3  (3173) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2947) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (200) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1295) Paraquat 5 mM 48 hrs, 4-day adult  (535) Paraquat 10 mM 48 hrs, 4-day adult  (718) Rotenone 2 μg 12 hrs, larvae L3  (3088) Rotenone 8 μg 12 hrs, larvae L3  (3110) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (1343) cold shock, 4-day adult  (1748) heat shock, 4-day adult  (1871) Cadmium 50 mM 6 hrs, larvae L3  (2881) Cadmium 50 mM 12 hrs, larvae L3  (2509) Cadmium 50 mM 48 hrs, 4-day adult  (1977) Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3  (1476) Copper 15 mM 48 hrs, 4-day adult  142 Zinc 5 mM 12 hrs, larvae L3  (2149) Zinc 4.5 mM 48 hrs, 4-day adult  (601) Ethanol 2.5% 3 hrs, larvae L3  (290) Ethanol 5% 3 hrs, larvae L3  (2308) Ethanol 10% 3 hrs, larvae L3  (3173) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (2947) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (200) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1295) Paraquat 5 mM 48 hrs, 4-day adult  (535) Paraquat 10 mM 48 hrs, 4-day adult  (718) Rotenone 2 μg 12 hrs, larvae L3  (3088) Rotenone 8 μg 12 hrs, larvae L3  (3110) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1343 cold shock, 4-day adult    1748 heat shock, 4-day adult    1871 Cadmium 50 mM 6 hrs, larvae L3    2881 Cadmium 50 mM 12 hrs, larvae L3    2509 Cadmium 50 mM 48 hrs, 4-day adult    1977 Cadmium 100 mM 48 hrs, 4-day adult    16 Copper 0.5 mM 12 hrs, larvae L3    1476 Copper 15 mM 48 hrs, 4-day adult    142 Zinc 5 mM 12 hrs, larvae L3    2149 Zinc 4.5 mM 48 hrs, 4-day adult    601 Ethanol 2.5% 3 hrs, larvae L3    290 Ethanol 5% 3 hrs, larvae L3    2308 Ethanol 10% 3 hrs, larvae L3    3173 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2947 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    200 Caffeine 25 mg/ml 48 hrs, 4-day adult    1295 Paraquat 5 mM 48 hrs, 4-day adult    535 Paraquat 10 mM 48 hrs, 4-day adult    718 Rotenone 2 μg 12 hrs, larvae L3    3088 Rotenone 8 μg 12 hrs, larvae L3    3110 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_16
External Data & Images
Linkouts	BDGP expression data • GH01508 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035665 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6483-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Jon65Aiii Stages(s) 7-8 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Jon65AiiiGD6033 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Jon65Aiii Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Jon65Aiii Class Mutagen Stocks Known lesion Jon65AiiiGD6033 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Jon65AiiiKK112736 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Jon65AiiiNIG.6483R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel7210 (Ryder, 2004.4.26) Df(3L)Exel8101 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6033} NA P{KK112736} NA P{NIG.6483R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
endopeptidase activity non-traceable author statement (Ross et al., 2003) serine-type endopeptidase activity inferred from sequence or structural similarity with UniProtKB:P08897 (FlyBase, 1992-)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 (FlyBase Curators et al., 2004-) non-traceable author statement (Ross et al., 2003)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Jon65Aiii allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64140 DroID - A comprehensive database of gene and protein interactions. • FBgn0035665 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38683
Orthologs
OrthoDB Orthologs (272) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6T1J6T Dipteran inclusive ortholog search EOG634WFW Insect inclusive ortholog search EOG6NVXG9 Arthropod inclusive ortholog search EOG673N7R Metazoa inclusive ortholog search EOG6NKQP1
Orthologs in Drosophila Species (EOG6T1J6T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Jon65Aiii     Drosophila simulans   Dsim\GD13923     Drosophila sechellia   Dsec\GM14741     Drosophila erecta   Dere\GG15308 Y   Drosophila yakuba   Dyak\GE21529     Drosophila ananassae   Dana\GF10667     Drosophila pseudoobscura pseudoobscura   Dpse\GA19627     Drosophila persimilis   Dper\GL15538     Drosophila willistoni   Dwil\GK11557     Drosophila willistoni   Dwil\GK16889     Drosophila virilis   Dvir\GJ12930     Drosophila virilis   Dvir\GJ12929     Drosophila mojavensis   Dmoj\GI16677     Drosophila grimshawi   Dgri\GH15027     Drosophila grimshawi   Dgri\GH15024     Drosophila grimshawi   Dgri\GH15025
Orthologs in non-Drosophila Dipterans (EOG634WFW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008212 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008215 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008218 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008199 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008208 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013281 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008196 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008217 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005642 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005663 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002432 Y Anopheles gambiae Malaria mosquito  Agam\AGAP006675 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005686 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005671 Y Anopheles gambiae Malaria mosquito  Agam\AGAP006674 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005689 Y Anopheles gambiae Malaria mosquito  Agam\AGAP012736 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007252 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005664 Y Anopheles gambiae Malaria mosquito  Agam\AGAP007251 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005687 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005691 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002134 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016102 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002135 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002128 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002156 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016105 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016103 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002133 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002125 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019083 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002127 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002126 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004990 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002098 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004986 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002129 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016104 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017990 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ004989 Y
Orthologs in non-Dipteran Insects (EOG6NVXG9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG010362 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011433 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB13645 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012777 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008515 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009527 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014431 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009528 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014428 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010584 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012791 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014427 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014022 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008514 Y Bombyx mori Silkmoth  Bmor\Bmo.13383 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014524 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007377 Y Bombyx mori Silkmoth  Bmor\BGIBMGA008513 Y Bombyx mori Silkmoth  Bmor\BGIBMGA014430 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009526 Y Pediculus humanus Human body louse  Phum\PHUM505030 Y Tribolium castaneum Red flour beetle  Tcas\P38 Y Tribolium castaneum Red flour beetle  Tcas\H118 Y Tribolium castaneum Red flour beetle  Tcas\H130 Y Tribolium castaneum Red flour beetle  Tcas\H112 Y Tribolium castaneum Red flour beetle  Tcas\H116 Y Tribolium castaneum Red flour beetle  Tcas\H122 Y Tribolium castaneum Red flour beetle  Tcas\TC010911 Y Tribolium castaneum Red flour beetle  Tcas\P96 Y Tribolium castaneum Red flour beetle  Tcas\P160 Y Tribolium castaneum Red flour beetle  Tcas\H115 Y Tribolium castaneum Red flour beetle  Tcas\H101 Y Tribolium castaneum Red flour beetle  Tcas\P165 Y Tribolium castaneum Red flour beetle  Tcas\H105 Y Tribolium castaneum Red flour beetle  Tcas\TC006246 Y Tribolium castaneum Red flour beetle  Tcas\P37 Y Tribolium castaneum Red flour beetle  Tcas\P149 Y Tribolium castaneum Red flour beetle  Tcas\P154 Y Tribolium castaneum Red flour beetle  Tcas\H143 Y Tribolium castaneum Red flour beetle  Tcas\H108 Y Tribolium castaneum Red flour beetle  Tcas\h102 Y Tribolium castaneum Red flour beetle  Tcas\yip7 Y Tribolium castaneum Red flour beetle  Tcas\P150 Y Tribolium castaneum Red flour beetle  Tcas\H104 Y Tribolium castaneum Red flour beetle  Tcas\P127 Y Tribolium castaneum Red flour beetle  Tcas\H113 Y Tribolium castaneum Red flour beetle  Tcas\TC010908 Y Tribolium castaneum Red flour beetle  Tcas\H111 Y Tribolium castaneum Red flour beetle  Tcas\H120 Y Tribolium castaneum Red flour beetle  Tcas\H152 Y Tribolium castaneum Red flour beetle  Tcas\P167 Y Tribolium castaneum Red flour beetle  Tcas\H107 Y Tribolium castaneum Red flour beetle  Tcas\P123 Y Tribolium castaneum Red flour beetle  Tcas\H110 Y Tribolium castaneum Red flour beetle  Tcas\P121 Y Tribolium castaneum Red flour beetle  Tcas\H148 Y Tribolium castaneum Red flour beetle  Tcas\P161 Y Tribolium castaneum Red flour beetle  Tcas\H114 Y Tribolium castaneum Red flour beetle  Tcas\H64 Y Tribolium castaneum Red flour beetle  Tcas\H132 Y Tribolium castaneum Red flour beetle  Tcas\H131 Y Tribolium castaneum Red flour beetle  Tcas\H119 Y Tribolium castaneum Red flour beetle  Tcas\h103 Y Tribolium castaneum Red flour beetle  Tcas\TC006247 Y Tribolium castaneum Red flour beetle  Tcas\P128 Y Tribolium castaneum Red flour beetle  Tcas\P166 Y
Orthologs in non-Insect Arthropods (EOG673N7R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MT-CYB Y Daphnia pulex Water flea  Dpux\CHY1H Y Daphnia pulex Water flea  Dpux\CHY1 Y Daphnia pulex Water flea  Dpux\JGI_V11_347753 Y Daphnia pulex Water flea  Dpux\CHY1A Y Daphnia pulex Water flea  Dpux\JGI_V11_347750 Y Daphnia pulex Water flea  Dpux\RPB2D Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\rbcL Y Daphnia pulex Water flea  Dpux\JGI_V11_195659 Y Daphnia pulex Water flea  Dpux\JGI_V11_230174 Y Daphnia pulex Water flea  Dpux\matK Y Daphnia pulex Water flea  Dpux\JGI_V11_347783 Y Daphnia pulex Water flea  Dpux\COI Y Daphnia pulex Water flea  Dpux\31.2 Y Daphnia pulex Water flea  Dpux\JGI_V11_316896 Y Daphnia pulex Water flea  Dpux\JGI_V11_332389 Y Daphnia pulex Water flea  Dpux\JGI_V11_100270 Y Daphnia pulex Water flea  Dpux\CO1 Y Daphnia pulex Water flea  Dpux\cytb Y Daphnia pulex Water flea  Dpux\CHY1C Y Daphnia pulex Water flea  Dpux\rec Y
Orthologs in non-Arthropod Metazoa (EOG6NKQP1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\try-4 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016868gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010750gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025575gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020315gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005427gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010205gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026191gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_000377gn Y Danio rerio Zebrafish  Drer\ENSDARG00000043173 Y Danio rerio Zebrafish  Drer\ela2 Y Danio rerio Zebrafish  Drer\zgc:112285 Y Danio rerio Zebrafish  Drer\ENSDARG00000010378 Y Danio rerio Zebrafish  Drer\f9b Y Danio rerio Zebrafish  Drer\zgc:112368 Y Danio rerio Zebrafish  Drer\si:dkey-57c15.4 Y Danio rerio Zebrafish  Drer\ENSDARG00000068726 Y Danio rerio Zebrafish  Drer\masp2 Y Danio rerio Zebrafish  Drer\f7 Y Danio rerio Zebrafish  Drer\LOC562139 Y Danio rerio Zebrafish  Drer\zgc:154142 Y Danio rerio Zebrafish  Drer\ENSDARG00000075719 Y Danio rerio Zebrafish  Drer\CR944667.3 Y Danio rerio Zebrafish  Drer\si:dkey-33i11.3 Y Danio rerio Zebrafish  Drer\ENSDARG00000017314 Y Danio rerio Zebrafish  Drer\DKEY-33I11.3 Y Danio rerio Zebrafish  Drer\ela3l Y Danio rerio Zebrafish  Drer\ENSDARG00000076045 Y Danio rerio Zebrafish  Drer\f10 Y Danio rerio Zebrafish  Drer\zgc:92511 Y Danio rerio Zebrafish  Drer\ENSDARG00000089722 Y Danio rerio Zebrafish  Drer\ctrb1 Y Danio rerio Zebrafish  Drer\ela2l Y Danio rerio Zebrafish  Drer\f9a Y Danio rerio Zebrafish  Drer\ENSDARG00000011144 Y Danio rerio Zebrafish  Drer\zgc:112160 Y Danio rerio Zebrafish  Drer\f7i Y Danio rerio Zebrafish  Drer\ctrl Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033013 Y Xenopus tropicalis Western clawed frog  Xtro\tmprss12 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000023914 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025253 Y Xenopus tropicalis Western clawed frog  Xtro\cela3b Y Xenopus tropicalis Western clawed frog  Xtro\c1s Y Xenopus tropicalis Western clawed frog  Xtro\cela3a Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033599 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014195 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033339 Y Xenopus tropicalis Western clawed frog  Xtro\f9 Y Xenopus tropicalis Western clawed frog  Xtro\f10 Y Xenopus tropicalis Western clawed frog  Xtro\gprin3 Y Xenopus tropicalis Western clawed frog  Xtro\ctrb1 Y Xenopus tropicalis Western clawed frog  Xtro\cela2a Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032160 Y Xenopus tropicalis Western clawed frog  Xtro\masp1 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000025157 Y Xenopus tropicalis Western clawed frog  Xtro\hpn Y Xenopus tropicalis Western clawed frog  Xtro\masp2 Y Xenopus tropicalis Western clawed frog  Xtro\c1r Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033050 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000014270 Y Xenopus tropicalis Western clawed frog  Xtro\ctrb2 Y Gallus gallus Domestic chicken  Ggal\LOC431235 Y Gallus gallus Domestic chicken  Ggal\C1R Y Gallus gallus Domestic chicken  Ggal\LOC771012 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000004866 Y Gallus gallus Domestic chicken  Ggal\MASP1 Y Gallus gallus Domestic chicken  Ggal\F9 Y Gallus gallus Domestic chicken  Ggal\CELA2A Y Gallus gallus Domestic chicken  Ggal\CTRL Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000006081 Y Gallus gallus Domestic chicken  Ggal\C1S Y Gallus gallus Domestic chicken  Ggal\CTRC Y Gallus gallus Domestic chicken  Ggal\MASP2 Y Mus musculus House mouse  Mmus\C1rl Y Mus musculus House mouse  Mmus\Cela3b Y Mus musculus House mouse  Mmus\Ctrl Y Mus musculus House mouse  Mmus\F9 Y Mus musculus House mouse  Mmus\Hpn Y Mus musculus House mouse  Mmus\Gm13011 Y Mus musculus House mouse  Mmus\Klk15 Y Mus musculus House mouse  Mmus\Cela1 Y Mus musculus House mouse  Mmus\Klk1b22 Y Mus musculus House mouse  Mmus\F10 Y Mus musculus House mouse  Mmus\Gm5077 Y Mus musculus House mouse  Mmus\C1s Y Mus musculus House mouse  Mmus\Cela2a Y Mus musculus House mouse  Mmus\Ctrb1 Y Mus musculus House mouse  Mmus\Tmprss12 Y Mus musculus House mouse  Mmus\C1ra Y Mus musculus House mouse  Mmus\Masp2 Y Mus musculus House mouse  Mmus\C1rb Y Mus musculus House mouse  Mmus\Masp1 Y Rattus norvegicus Norway rat  Rnor\Ctrl Y Rattus norvegicus Norway rat  Rnor\Ctrb1 Y Rattus norvegicus Norway rat  Rnor\Masp2 Y Rattus norvegicus Norway rat  Rnor\Klk15 Y Rattus norvegicus Norway rat  Rnor\Cela3b Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000003430 Y Rattus norvegicus Norway rat  Rnor\F10 Y Rattus norvegicus Norway rat  Rnor\LOC100362912 Y Rattus norvegicus Norway rat  Rnor\C1r Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000004725 Y Rattus norvegicus Norway rat  Rnor\Cela2a Y Rattus norvegicus Norway rat  Rnor\C1rl Y Rattus norvegicus Norway rat  Rnor\Ctrc Y Rattus norvegicus Norway rat  Rnor\C1s Y Rattus norvegicus Norway rat  Rnor\Masp1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021097 Y Homo sapiens Human  Hsap\CELA3B Y Homo sapiens Human  Hsap\TMPRSS12 Y Homo sapiens Human  Hsap\MASP1 Y Homo sapiens Human  Hsap\CELA3A Y Homo sapiens Human  Hsap\ENSG00000168925 Y Homo sapiens Human  Hsap\CELA1 Y Homo sapiens Human  Hsap\ELA2A Y Homo sapiens Human  Hsap\CTRL Y Homo sapiens Human  Hsap\KLK15 Y Homo sapiens Human  Hsap\F10 Y Homo sapiens Human  Hsap\CTRB2 Y Homo sapiens Human  Hsap\ENSG00000159403 Y Homo sapiens Human  Hsap\CELA2B Y Homo sapiens Human  Hsap\CTRC Y Homo sapiens Human  Hsap\FIX F9 Y Homo sapiens Human  Hsap\MASP2 Y Homo sapiens Human  Hsap\C1S Y Homo sapiens Human  Hsap\HPN Y
Human Orthologs (18)
Gene OMIM HGNC Hsap\CELA3B     Hsap\TMPRSS12     Hsap\MASP1     Hsap\CELA3A     Hsap\ENSG00000168925     Hsap\CELA1     Hsap\ELA2A     Hsap\CTRL     Hsap\KLK15     Hsap\F10     Hsap\CTRB2     Hsap\ENSG00000159403     Hsap\CELA2B     Hsap\CTRC     Hsap\FIX F9     Hsap\MASP2     Hsap\C1S     Hsap\HPN
AAA Orthologs (1) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG15308
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v103274 P{KK112736}VIE-260B v38184 w1118; P{GD6033}v38184/TM3
Genomic Clones ( 1 )
	BACR01O19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 186 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01508
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06504 GH08742 GH10087 GH12786 GH14302 GH14627 GH17587 GH19106 GH19188 GH22687 GH25061 LP01232 LP01866 LP02392 LP02656 LP03156 LP03815 LP03844 LP04401 LP04660 LP05431 LP06647 LP07527 LP07736 LP07858 LP08192 LP08527 LP08672 LP08844 LP08944 LP10449 LP11861 LP12181 LP12503 LP12515 LP12914 LP12931 LP13514 LP13937 LP14468 LP14653 LP15342 LP16144 LP16790 LP16819 LP17481 LP17593 LP17676 LP18310 LP18665 LP18987 LP22689 LP23754 RE02931 RE26153 RE55193 RE57885 RE69568
Other clones	9715 12507 55965 67621 75411 190655 Dmel_dig_000907_0673_3668 Dmel_dig_009720_0658_2820 Dmel_dig_013319_0685_3094 Dmel_dig_013892_0582_3367 Dmel_dig_016366_0660_0671 Dmel_neb_003221_0131_2877 Dmel_neb_011250_0171_3214 Dmel_neb_011371_0837_3131 Dmel_neb_012628_0656_1634 Dmel_neb_013205_0129_2169 Dmel_neb_013942_0876_3519 Dmel_neb_013976_0691_2872 Dmel_neb_014022_0689_1642 Dmel_neb_015343_0156_2286 EC00180 EC00277 EC00280 EC01544 EC28012 EC30266 EC34566 EC35612 EC42454 EC051049 EC051149 EC053172 EC053646 EC054152 EC054352 EC055592 EC055616 EC055877 EC056325 EC056415 EK109310 EK113859 EK172745 EK184345 EK195728 EK205233 EK212925 EK292815 IP04422 IP04622 IP06045 IP06245 IP08335 IP08765 IP09749 IP09849 IP10052 IP10152 IP10252 IP10352 RP003000654 RP003001711 RP003062816 RP003075433 RP003079976 RP003083366 RP003087536 RP003099153 RP003105449 RP003105725 RP003131789 RP003141219 RP003150976 RP003168256 RP003179485 RP003180593 RP003188400 RP003188568 RP003190029 RP003193832 RP003197706 RP003208271 RP003210629 RP003213025 RP003227294 RP003228843 RP003229481 RP003234013 RP003250749 RP003251506 RP003252785 RP003265089 RP003267768 RP003276044 RP003278460 RP003281674 RP003288029 RP003293225 RP003301778 RP003312935 RP003319878 RP003330610 RP003334376 RP003339185 RP003344472 RP003349985 RP003358610 RP003361650 RP003384451 RP003390952 RP003456565 RP003471672 RP003488524 RP003494251 RP003525668 RP003560903 RP003564200 RP003571997 RP003595013 RP003607752 RP003639128 RP003649507 RP003652601 RP003663868 RP003670436 RP003673821 UUGC0405
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035665 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38683
Antibody Information
Other Information
Discoverer
Etymology
	One of a number of genes isolated from a cDNA library made from third instar salivary glands, but subsequently found not to be expressed in the salivary glands but instead expressed specifically and abundantly in the midgut (which resulted in contamination of the original cDNA library). This surprising discovery prompted the name "Jonah" for this family of genes, after the Biblical prophet who unexpectedly turned up in the gut. (Carlson and Hogness, 1985)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Jon65Aiii anon-EST:GressD16 (Ashburner, 2004.6.30) Source for merge of: Jon65Aiii anon-WO0140519.59 (FlyBase, 1996-) Source for merge of: Jon65Aiii CG6483 (Schaeffer, 2004.1.1)
Additional comments	Source for merge of Jon65Aiii anon-WO0140519.59 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139756 RefSeq (Proteins) • NP_648013 DDBJ / EMBL / GenBank • AAF50713 AAM12248 AI062337 AW940050 AX154710 AY095514 X65275 Entrez Gene - A searchable database of RefSeq genes. • 38683 UniProtKB/TrEMBL • Q9VRS7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase S1, trypsin family, active site (IPR018114) Peptidase S1 (IPR001254) Peptidase S1A, chymotrypsin-type (IPR001314) Trypsin-like cysteine/serine peptidase domain (IPR009003) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH01508
Linkouts
	BioGRID - A database of protein and genetic interactions • 64140 DroID - A comprehensive database of gene and protein interactions. • FBgn0035665 DRSC - Results from RNAi screens. • FBgn0035665 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035665 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6483-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035665 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38683 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38683 modMine - Data generated by the modENCODE project. • FBgn0035665
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-EST:GressD16   anon-WO0140519.59   CG6483 (McGraw et al., 2004, Ashburner, 2004.6.30, Anholt and Mackay, 2001, Zou et al., 2000, Li et al., 2009, Roxstrom-Lindquist et al., 2004, Keleman et al., 2009.8.5, Nair et al., 2007) CG6484 (Parisi et al., 2004) Jon65A (Anholt and Mackay, 2001, Lindsley and Zimm, 1992, ) Jon65Aiii (Li et al., 2009, González et al., 2010, Japanese National Institute of Genetics, 2012.5.21) jon65Aiii (Ferjoux et al., 2007) SP98 (Ross et al., 2003)
Name Synonym	Jonah 65 (Nair et al., 2007) Jonah 65A (Schaeffer, 2004.1.1) Jonah 65Aiii (Carpenter et al., 2009)
Secondary FlyBase IDs
	FBgn0001286 FBgn0025329 FBgn0044570
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 14 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 2 ) Book  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Patent  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...