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Gene Dmel\CG8368

General Information
Symbol	Dmel\CG8368	Species	D. melanogaster
Name		Annotation symbol	CG8368
Feature type	protein_coding_gene	FlyBase ID	FBgn0035707
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65B5-65C1	Sequence location	3L:6,597,237..6,601,860 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8368 (FBgn0035707). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: exonuclease activity; nucleic acid binding. The biological processes in which it is involved are not known. 8 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Exonuclease; Exonuclease, RNase T/DNA polymerase III; Ribonuclease H-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628537_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG8368. Gene sequence location is 3L:6597237..6601860.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA10981 BKN21945
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65B5-65C1   Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8368 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8368-RA FBtr0076977  NM_139793   2506   681 CG8368-RB FBtr0076976  NM_168172   2458   681
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8368-PA   FBpp0076686   76.7   681   6.13     NP_648050   AAF50654 CG8368-PB   FBpp0076685   76.7   681   6.13     NP_729177   AAN12085
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Exonuclease (IPR006055) Ribonuclease H-like (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141430   AA141431   AE014296 AAF50654   AE014296 AAN12085   AI533623   AI944952   AI945868   AI945927   BE975582   BE976266   BE977504   BF485635   BF487344   BF487896   BF488624   BF488665   BF489430   BF489438   BF489536   BF490203   BF490387   BF490449   BF495809   BF496005   BF496035   BF497150   BF497840   BF498079   BF498768   BF498949   BF501167   BF501212   BF501236   BF502278   BF505974   BG634122   BG634740   BG635326   BI141961   BI171119   BI215268   BI234565   BI234822   BP554619   BT023775   CO188871   CO287921   CO288611   CO322953   CO327172   CO345569   CZ469115   CZ469116   EC070175   EC196143   EC215905   EC217999   EC218176   EC227482   EC242308   EC255239   EC256565   EL880779   EL880896   EV580949   EV586398   EV587007   EV587644   EV587722   EV589571   EV589781   EV590249   EV590335   EV591388   EV591700
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VRX7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035707    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035707 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035707 expression level Developmental Stage   Expression Level embryo 00-02hr    2737 embryo 02-04hr    3047 embryo 04-06hr    2236 embryo 06-08hr    2687 embryo 08-10hr    2866 embryo 10-12hr    2491 embryo 12-14hr    2022 embryo 14-16hr    1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr    1921 embryo 22-24hr    1689 larva L1    2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6    1927 larva L3 puffstage 7-9    2221 white prepupae new    2089 white prepupae 12hr    3091 white prepupae 24hr    4558 pupae 2d postWPP    5505 pupae 3d postWPP    5400 pupae 4d postWPP    4615 adult male 01day    7709 adult male 05day    9871 adult male 30day    9343 adult female 01day    1825 adult female 05day    2505 adult female 30day    2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2737) embryo 02-04hr  (3047) embryo 04-06hr  (2236) embryo 06-08hr  (2687) embryo 08-10hr  (2866) embryo 10-12hr  (2491) embryo 12-14hr  (2022) embryo 14-16hr  (1403) embryo 16-18hr  (1298) embryo 18-20hr  (1033) embryo 20-22hr  (1921) embryo 22-24hr  (1689) larva L1  (2456) larva L2  (1388) larva L3 12hr old  (1085) larva L3 puffstage 1-2  (1144) larva L3 puffstage 3-6  (1927) larva L3 puffstage 7-9  (2221) white prepupae new  (2089) white prepupae 12hr  (3091) white prepupae 24hr  (4558) pupae 2d postWPP  (5505) pupae 3d postWPP  (5400) pupae 4d postWPP  (4615) adult male 01day  (7709) adult male 05day  (9871) adult male 30day  (9343) adult female 01day  (1825) adult female 05day  (2505) adult female 30day  (2366) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2737) embryo 02-04hr  (3047) embryo 04-06hr  (2236) embryo 06-08hr  (2687) embryo 08-10hr  (2866) embryo 10-12hr  (2491) embryo 12-14hr  (2022) embryo 14-16hr  1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr  (1921) embryo 22-24hr  (1689) larva L1  (2456) larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6  (1927) larva L3 puffstage 7-9  (2221) white prepupae new  (2089) white prepupae 12hr  (3091) white prepupae 24hr  (4558) pupae 2d postWPP  (5505) pupae 3d postWPP  (5400) pupae 4d postWPP  (4615) adult male 01day  (7709) adult male 05day  (9871) adult male 30day  (9343) adult female 01day  (1825) adult female 05day  (2505) adult female 30day  (2366) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2737 embryo 02-04hr    3047 embryo 04-06hr    2236 embryo 06-08hr    2687 embryo 08-10hr    2866 embryo 10-12hr    2491 embryo 12-14hr    2022 embryo 14-16hr    1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr    1921 embryo 22-24hr    1689 larva L1    2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6    1927 larva L3 puffstage 7-9    2221 white prepupae new    2089 white prepupae 12hr    3091 white prepupae 24hr    4558 pupae 2d postWPP    5505 pupae 3d postWPP    5400 pupae 4d postWPP    4615 adult male 01day    7709 adult male 05day    9871 adult male 30day    9343 adult female 01day    1825 adult female 05day    2505 adult female 30day    2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2737 embryo 02-04hr    3047 embryo 04-06hr    2236 embryo 06-08hr    2687 embryo 08-10hr    2866 embryo 10-12hr    2491 embryo 12-14hr    2022 embryo 14-16hr    1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr    1921 embryo 22-24hr    1689 larva L1    2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6    1927 larva L3 puffstage 7-9    2221 white prepupae new    2089 white prepupae 12hr    3091 white prepupae 24hr    4558 pupae 2d postWPP    5505 pupae 3d postWPP    5400 pupae 4d postWPP    4615 adult male 01day    7709 adult male 05day    9871 adult male 30day    9343 adult female 01day    1825 adult female 05day    2505 adult female 30day    2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035707 expression level Developmental Stage   Expression Level embryo 00-02hr    2737 embryo 02-04hr    3047 embryo 04-06hr    2236 embryo 06-08hr    2687 embryo 08-10hr    2866 embryo 10-12hr    2491 embryo 12-14hr    2022 embryo 14-16hr    1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr    1921 embryo 22-24hr    1689 larva L1    2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6    1927 larva L3 puffstage 7-9    2221 white prepupae new    2089 white prepupae 12hr    3091 white prepupae 24hr    4558 pupae 2d postWPP    5505 pupae 3d postWPP    5400 pupae 4d postWPP    4615 adult male 01day    7709 adult male 05day    9871 adult male 30day    9343 adult female 01day    1825 adult female 05day    2505 adult female 30day    2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2737) embryo 02-04hr  (3047) embryo 04-06hr  (2236) embryo 06-08hr  (2687) embryo 08-10hr  (2866) embryo 10-12hr  (2491) embryo 12-14hr  (2022) embryo 14-16hr  (1403) embryo 16-18hr  (1298) embryo 18-20hr  (1033) embryo 20-22hr  (1921) embryo 22-24hr  (1689) larva L1  (2456) larva L2  (1388) larva L3 12hr old  (1085) larva L3 puffstage 1-2  (1144) larva L3 puffstage 3-6  (1927) larva L3 puffstage 7-9  (2221) white prepupae new  (2089) white prepupae 12hr  (3091) white prepupae 24hr  (4558) pupae 2d postWPP  (5505) pupae 3d postWPP  (5400) pupae 4d postWPP  (4615) adult male 01day  (7709) adult male 05day  (9871) adult male 30day  (9343) adult female 01day  (1825) adult female 05day  (2505) adult female 30day  (2366) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2737) embryo 02-04hr  (3047) embryo 04-06hr  2236 embryo 06-08hr  (2687) embryo 08-10hr  (2866) embryo 10-12hr  (2491) embryo 12-14hr  2022 embryo 14-16hr  1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr  1921 embryo 22-24hr  1689 larva L1  2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6  1927 larva L3 puffstage 7-9  2221 white prepupae new  2089 white prepupae 12hr  (3091) white prepupae 24hr  (4558) pupae 2d postWPP  (5505) pupae 3d postWPP  (5400) pupae 4d postWPP  (4615) adult male 01day  (7709) adult male 05day  (9871) adult male 30day  (9343) adult female 01day  1825 adult female 05day  (2505) adult female 30day  2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2737 embryo 02-04hr    3047 embryo 04-06hr    2236 embryo 06-08hr    2687 embryo 08-10hr    2866 embryo 10-12hr    2491 embryo 12-14hr    2022 embryo 14-16hr    1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr    1921 embryo 22-24hr    1689 larva L1    2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6    1927 larva L3 puffstage 7-9    2221 white prepupae new    2089 white prepupae 12hr    3091 white prepupae 24hr    4558 pupae 2d postWPP    5505 pupae 3d postWPP    5400 pupae 4d postWPP    4615 adult male 01day    7709 adult male 05day    9871 adult male 30day    9343 adult female 01day    1825 adult female 05day    2505 adult female 30day    2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2737 embryo 02-04hr    3047 embryo 04-06hr    2236 embryo 06-08hr    2687 embryo 08-10hr    2866 embryo 10-12hr    2491 embryo 12-14hr    2022 embryo 14-16hr    1403 embryo 16-18hr    1298 embryo 18-20hr    1033 embryo 20-22hr    1921 embryo 22-24hr    1689 larva L1    2456 larva L2    1388 larva L3 12hr old    1085 larva L3 puffstage 1-2    1144 larva L3 puffstage 3-6    1927 larva L3 puffstage 7-9    2221 white prepupae new    2089 white prepupae 12hr    3091 white prepupae 24hr    4558 pupae 2d postWPP    5505 pupae 3d postWPP    5400 pupae 4d postWPP    4615 adult male 01day    7709 adult male 05day    9871 adult male 30day    9343 adult female 01day    1825 adult female 05day    2505 adult female 30day    2366 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035707    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035707 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035707 expression level Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  (1309.3) Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  (1309.3) Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035707 expression level Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  (1309.3) Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    97.4   NA  Eye    83.2   NA  Brain    96.6   151.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    91   NA  Crop    99.7   41.7  Midgut    58.3   83.1  Hindgut    77   29.6  Malpighian Tubules    79   157  Fat Body    153.4   147.4  Salivary Gland    84.8   NA  Heart    83.175   115.5  Trachea    NA   NA  VirginFemale Spermatheca    89.2   NA  InseminatedFemale Spermatheca    118.5   NA  Ovary    258.2   NA  Testis    1309.3   NA  Male Accessory Gland    188.7   107.15  Carcass    82.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8368-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG8368GD13906 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CG8368 Class Mutagen Stocks Known lesion CG8368LA00675 2 -- CG8368c04255 piggyBac transposase 1 -- CG8368zpg3-ex P-element activity 0 Yes CG8368zpg3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8368 Class Mutagen Stocks Known lesion CG8368GD13906 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368HMS00724 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368KK101144 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368t6.15 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13906} NA P{KK101144} NA P{TRiP.HMS00724} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG8368c04255 NA insertion of mobile activating element P{Mae-UAS.6.11}zpgLA00675 NA insertion of enhancer trap P{lacW}zpg3 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
exonuclease activity inferred from electronic annotation with InterPro:IPR006055 (FlyBase Curators et al., 2004-) nucleic acid binding inferred from electronic annotation with InterPro:IPR012337 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR006055 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8368 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64190 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035707 DroID - A comprehensive database of gene and protein interactions. • FBgn0035707 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38740
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23543 Dere\GG15351 Dgri\GH15165 Dmoj\GI12104 Dper\GL13270 Dpse\GA21025 Dsec\GM14791 Dsim\GD13963 Dvir\GJ13378 Dwil\GK12547 Dyak\GE21570
Curated drosophilid orthologs	Dpse\GA21025
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006744-PA Aedes aegypti (mosquito) AGAP005406-PA Anopheles gambiae (mosquito) XP_394242.2 Apis mellifera (honey bee) XP_001947657.1 Acyrthosiphon pisum (pea aphid) At5g25800.1 Arabidopsis thaliana (wall cress) 65329 Branchiostoma floridae (lancelet) BGIBMGA011782-PA Bombyx mori (silk worm) ENSBTAP00000008458 Bos taurus (bovine) CBP29419 Caenorhabditis briggsae (nematode) CAGL0M11638g Candida glabrata (haploid yeast) cn14229 Cryptococcus neoformans (yeast-like fungus) CPIJ010599 Culex pipens (mosquito) 184521 Capitella spl (polychaete worm) 227396 Daphnia pulex (daphnia) ENSGACP00000025783 Gymnopilus aculeatus (mushroom) GL50803_14763 Giardia lamblia (flagellated protozoan) 188219 Hypsipyla robusta (cedar shoot borer) ISCW000182-PA Ixodes scapularis (deer tick) 229335 Lottia gigantea (owl limpet) XP_001607810.1 Nasonia vitripennis (wasp) PHUM010618-PA Pediculus humanus (human body louse) 111646 Physcomitrella patens (moss) 801307 Populus trichocarpa (black cottonwood) Smp_160090.1 Schistosoma mansoni (trematode parasite) XP_001202102.1 Strongylocentrotus purpuratus (purple sea urchin) XP_971901.1 Tribolium castaneum (red flour beetle) ENSTRUP00000039073 Takifugu rubripes (pufferfish Takifugu) YALI0B15400g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10915 LH16522 ISCW000182 FBgn0238825 FBgn0214557 FBgn0200603 FBgn0185659 FBgn0169712 JGI_V11_227396 JGI_V11_326896 FBgn0081014 FBgn0150876 FBgn0134861 FBgn0122640 FBgn0107603 FBgn0100537 CPIJ010599 BGIBMGA011782 ACYPI009265 GB12175 AGAP005406 AAEL006744 PB22896 PHUM519520 GLEAN_03027
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	32931 y1 sc* v1; P{TRiP.HMS00724}attP2 22247 y1 w67c23; P{Mae-UAS.6.11}zpgLA00675 CG8368LA00675/TM3, Sb1 Ser1
Harvard	- PBac{PB}CG8368c04255
Kyoto	120675 y* w*; P{Mae-UAS.6.11}zpgLA00675
VDRC	v108563 P{KK101144}VIE-260B v45259 w1118; P{GD13906}v45259
Genomic Clones ( 2 )
	BACR26E12 BACR26E20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 70 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29573
Other clones	DPiM_LD29573
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08315 AT09468 AT09708 AT09742 AT11252 AT12142 AT12439 AT13239 AT13438 AT16412 AT16475 AT16507 AT17955 AT19729 AT22117 AT23001 AT24106 AT24167 AT25548 AT25558 AT25583 AT26514 AT26831 AT26915 AT30193 AT31055 AT31873 RE12804 RE21624 RE30282 RE30572 SD05518 SD15941
Other clones	176026 214435.80 214471.67 bs07c12 bs17g07 bs18d09 bs44a09 bs48g05 bs64g11 CK01.39D.E9 CK01.52A.F8 CK01.84D.E1 CK01.87B.G10 CK01.96B.H6 CK01731 Dmel_dig_020922_0680_0732 Dmel_neb_011109_0156_2338 Dmel_neb_011673_0341_3425 Dmel_neb_012109_0432_2055 Dmel_neb_012417_0449_1032 Dmel_neb_012595_0101_1652 Dmel_neb_012717_0172_1557 Dmel_neb_013404_0371_1614 Dmel_neb_013506_0381_2412 Dmel_neb_013723_0193_2863 Dmel_neb_013920_0391_1383 EK042256 EK067217 EK068959 EK189303 EP06235 EP22309 FGM230H01 IP10625 IP10725
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38740
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139793 NM_168172 RefSeq (Proteins) • NP_648050 NP_729177 DDBJ / EMBL / GenBank • AA141430 AA141431 AAF50654 AAN12085 AI944952 AI945868 AI945927 BF497840 CZ469115 CZ469116 Entrez Gene - A searchable database of RefSeq genes. • 38740 UniProtKB/TrEMBL • Q9VRX7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Exonuclease (IPR006055) Ribonuclease H-like (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64190 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035707 DroID - A comprehensive database of gene and protein interactions. • FBgn0035707 DRSC - Results from RNAi screens. • FBgn0035707 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8368-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38740 InParanoid A subset of ortholog calls from InParanoid. • AAEL006744-PA Aedes aegypti (mosquito) AGAP005406-PA Anopheles gambiae (mosquito) XP_394242.2 Apis mellifera (honey bee) XP_001947657.1 Acyrthosiphon pisum (pea aphid) At5g25800.1 Arabidopsis thaliana (wall cress) 65329 Branchiostoma floridae (lancelet) BGIBMGA011782-PA Bombyx mori (silk worm) ENSBTAP00000008458 Bos taurus (bovine) CBP29419 Caenorhabditis briggsae (nematode) CAGL0M11638g Candida glabrata (haploid yeast) cn14229 Cryptococcus neoformans (yeast-like fungus) CPIJ010599 Culex pipens (mosquito) 184521 Capitella spl (polychaete worm) 227396 Daphnia pulex (daphnia) ENSGACP00000025783 Gymnopilus aculeatus (mushroom) GL50803_14763 Giardia lamblia (flagellated protozoan) 188219 Hypsipyla robusta (cedar shoot borer) ISCW000182-PA Ixodes scapularis (deer tick) 229335 Lottia gigantea (owl limpet) XP_001607810.1 Nasonia vitripennis (wasp) PHUM010618-PA Pediculus humanus (human body louse) 111646 Physcomitrella patens (moss) 801307 Populus trichocarpa (black cottonwood) Smp_160090.1 Schistosoma mansoni (trematode parasite) XP_001202102.1 Strongylocentrotus purpuratus (purple sea urchin) XP_971901.1 Tribolium castaneum (red flour beetle) ENSTRUP00000039073 Takifugu rubripes (pufferfish Takifugu) YALI0B15400g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38740 modMine - Data generated by the modENCODE project. • FBgn0035707 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10915 LH16522 ISCW000182 FBgn0238825 FBgn0214557 FBgn0200603 FBgn0185659 FBgn0169712 JGI_V11_227396 JGI_V11_326896 FBgn0081014 FBgn0150876 FBgn0134861 FBgn0122640 FBgn0107603 FBgn0100537 CPIJ010599 BGIBMGA011782 ACYPI009265 GB12175 AGAP005406 AAEL006744 PB22896 PHUM519520 GLEAN_03027
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG8368 (FlyBase Curators, 2008, Keleman et al., 2009.8.5, Ni et al., 2010.12.1)
Name Synonym	RNase H-like (Tazuke et al., 2002)
Secondary FlyBase IDs
References ( 16 )
Research paper	Tazuke et al., 2002, Development 129(10): 2529--2539 A germline-specific gap junction protein required for survival of differentiating early germ cells. [FBrf0146994]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]