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Gene Dmel\CG8368

General Information
Symbol	Dmel\CG8368	Species	D. melanogaster
Name		Annotation symbol	CG8368
Feature type	protein_coding_gene	FlyBase ID	FBgn0035707
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65B5-65C1	Sequence location	3L:6,596,784..6,601,839 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8368 (FBgn0035707). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: exonuclease activity; nucleic acid binding. The biological processes in which it is involved are not known. 9 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Exonuclease; Exonuclease, RNase T/DNA polymerase III; Ribonuclease H-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1628537_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG8368. Gene sequence location is 3L:6596784..6601839.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65B5-65C1   Limits computationally determined from genome sequence between P{PZ}l(3)0209402094 and P{lacW}l(3)L4060L4060
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8368 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8368-RA FBtr0076977  NM_139793   2505   681 CG8368-RB FBtr0076976  NM_168172   2821   681
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8368-PA   FBpp0076686   76.7   681   6.13     NP_648050   AAF50654 CG8368-PB   FBpp0076685   76.7   681   6.13     NP_729177   AAN12085
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Exonuclease (IPR006055) Ribonuclease H-like domain (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141430   AA141431   AE014296 AAF50654   AE014296 AAN12085   AI533623   AI944952   AI945868   AI945927   BE975582   BE976266   BE977504   BF485635   BF487344   BF487896   BF488624   BF488665   BF489430   BF489438   BF489536   BF490203   BF490387   BF490449   BF495809   BF496005   BF496035   BF497150   BF497840   BF498079   BF498768   BF498949   BF501167   BF501212   BF501236   BF502278   BF505974   BG634122   BG634740   BG635326   BI141961   BI171119   BI215268   BI234565   BI234822   BP554619   BT023775   CO188871   CO287921   CO288611   CO322953   CO327172   CO345569   CZ469115   CZ469116   EC070175   EC196143   EC215905   EC217999   EC218176   EC227482   EC242308   EC255239   EC256565   EL880779   EL880896   EV580949   EV586398   EV587007   EV587644   EV587722   EV589571   EV589781   EV590249   EV590335   EV591388   EV591700
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VRX7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  (1309.3) Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  (1309.3) Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  (1309.3) Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis  1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    151.75 Larval Midgut    41.7 Larval Hindgut    83.1 Larval Malpighian Tubules    29.6 Larval Fat Body    157 Larval Salivary Gland    147.4 Larval Trachea    115.5 Larval Carcass    107.15 Adult Head    97.4 Adult Eye    83.2 Adult Brain    96.6 Adult Thoracic-Abdominal Ganglion    91 Adult Crop    99.7 Adult Midgut    58.3 Adult Hindgut    77 Adult Malpighian Tubules    79 Adult Fat Body    153.4 Adult Salivary Gland    84.8 Adult Heart    83.175 Adult VirginFemale Spermatheca    89.2 Adult InseminatedFemale Spermatheca    118.5 Adult Ovary    258.2 Adult Testis    1309.3 Adult Male Accessory Gland    188.7 Adult Carcass    82.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    97.4   NA  Eye    83.2   NA  Brain    96.6   151.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    91   NA  Crop    99.7   41.7  Midgut    58.3   83.1  Hindgut    77   29.6  Malpighian Tubules    79   157  Fat Body    153.4   147.4  Salivary Gland    84.8   NA  Heart    83.175   115.5  Trachea    NA   NA  VirginFemale Spermatheca    89.2   NA  InseminatedFemale Spermatheca    118.5   NA  Ovary    258.2   NA  Testis    1309.3   NA  Male Accessory Gland    188.7   107.15  Carcass    82.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8    34 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    304 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (83) central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8  (34) carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  (30) ovary, mated 4-day female    25 testis, mated 4-day male  (304) accessory gland, mated 4-day male  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8    34 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male  (304) accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8    34 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    304 accessory gland, mated 4-day male    36 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8    34 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    304 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (83) central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8  (34) carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female  30 ovary, mated 4-day female    25 testis, mated 4-day male  (304) accessory gland, mated 4-day male  (36) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8    34 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male  (304) accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    83 central nervous system, larvae L3    11 central nervous system, pupae P8    8 head, virgin 1-day female    4 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    5 head, mated 4-day female    9 head, mated 20-day female    5 head, mated 1-day male    5 head, mated 4-day male    7 head, mated 20-day male    7 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    7 digestive system, 4-day adult    10 digestive system, 20-day adult    7 fat body, larvae L3 wandering    2 fat body, white prepupae    24 fat body, pupae P8    34 carcass, larvae L3 wandering    10 carcass, 1-day adult    4 carcass, 4-day adult    9 carcass, 20-day adult    6 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    304 accessory gland, mated 4-day male    36 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    26 embryo 06-08hr    31 embryo 08-10hr    33 embryo 10-12hr    29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1    28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    37 white prepupae 24hr    55 pupae 2d postWPP    66 pupae 3d postWPP    65 pupae 4d postWPP    54 adult male 01day    93 adult male 05day    118 adult male 30day    111 adult female 01day    21 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (31) embryo 02-04hr  (35) embryo 04-06hr  26 embryo 06-08hr  (31) embryo 08-10hr  (33) embryo 10-12hr  (29) embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1  (28) larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  26 white prepupae new    25 white prepupae 12hr  (37) white prepupae 24hr  (55) pupae 2d postWPP  (66) pupae 3d postWPP  (65) pupae 4d postWPP  (54) adult male 01day  (93) adult male 05day  (118) adult male 30day  (111) adult female 01day    21 adult female 05day  (29) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    26 embryo 06-08hr    31 embryo 08-10hr    33 embryo 10-12hr    29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1    28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    37 white prepupae 24hr    55 pupae 2d postWPP    66 pupae 3d postWPP    65 pupae 4d postWPP    54 adult male 01day    93 adult male 05day  (118) adult male 30day  (111) adult female 01day    21 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    26 embryo 06-08hr    31 embryo 08-10hr    33 embryo 10-12hr    29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1    28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    37 white prepupae 24hr    55 pupae 2d postWPP    66 pupae 3d postWPP    65 pupae 4d postWPP    54 adult male 01day    93 adult male 05day    118 adult male 30day    111 adult female 01day    21 adult female 05day    29 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    26 embryo 06-08hr    31 embryo 08-10hr    33 embryo 10-12hr    29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1    28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    37 white prepupae 24hr    55 pupae 2d postWPP    66 pupae 3d postWPP    65 pupae 4d postWPP    54 adult male 01day    93 adult male 05day    118 adult male 30day    111 adult female 01day    21 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  31 embryo 02-04hr  (35) embryo 04-06hr  26 embryo 06-08hr  31 embryo 08-10hr  (33) embryo 10-12hr  29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1  28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9  26 white prepupae new    25 white prepupae 12hr  (37) white prepupae 24hr  (55) pupae 2d postWPP  (66) pupae 3d postWPP  (65) pupae 4d postWPP  (54) adult male 01day  (93) adult male 05day  (118) adult male 30day  (111) adult female 01day    21 adult female 05day  29 adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    26 embryo 06-08hr    31 embryo 08-10hr    33 embryo 10-12hr    29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1    28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    37 white prepupae 24hr    55 pupae 2d postWPP    66 pupae 3d postWPP    65 pupae 4d postWPP    54 adult male 01day    93 adult male 05day  118 adult male 30day  111 adult female 01day    21 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    31 embryo 02-04hr    35 embryo 04-06hr    26 embryo 06-08hr    31 embryo 08-10hr    33 embryo 10-12hr    29 embryo 12-14hr    23 embryo 14-16hr    16 embryo 16-18hr    15 embryo 18-20hr    12 embryo 20-22hr    22 embryo 22-24hr    19 larva L1    28 larva L2    16 larva L3 12hr old    12 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    37 white prepupae 24hr    55 pupae 2d postWPP    66 pupae 3d postWPP    65 pupae 4d postWPP    54 adult male 01day    93 adult male 05day    118 adult male 30day    111 adult female 01day    21 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    20 Schneider line 2 Sg4    23 embryonic 1182-4H    18 embryonic GM2    15 embryonic Kc167    13 embryonic S1    11 embryonic S3    20 leg disc CME L1    21 wing disc CME-W2    18 wing disc ML-DmD8    19 wing disc ML-DmD9    15 wing disc ML-DmD16-c3    20 wing disc ML-DmD21    24 wing disc ML-DmD32    15 haltere disc ML-DmD17-c3    19 eye-antennal disc ML-DmD11    18 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    22 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    18 tumorous blood cells mbn2    18 ovary fGS/OSS    15 ovary OSC    17 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    49 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (49) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    49 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    49 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    49 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (35) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult  (40) Ethanol 2.5% 3 hrs, larvae L3  (37) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (49) Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    49 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    14 heat shock, 4-day adult    23 Cadmium 50 mM 6 hrs, larvae L3    9 Cadmium 50 mM 12 hrs, larvae L3    13 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    35 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    40 Ethanol 2.5% 3 hrs, larvae L3    37 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    49 Rotenone 2 μg 12 hrs, larvae L3    12 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8368-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG8368GD13906 Phenotype manifest in Allele
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of CG8368 Class Mutagen Stocks Known lesion CG8368LA00675 2 -- CG8368c04255 piggyBac transposase 1 -- CG8368zpg3-ex P-element activity 0 Yes CG8368zpg3 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8368 Class Mutagen Stocks Known lesion CG8368GD13906 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368HMS00724 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368HMS02471 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368KK101144 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8368t6.15 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13906} NA P{KK101144} NA P{TRiP.HMS00724} NA P{TRiP.HMS02471} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}CG8368c04255 NA insertion of mobile activating element P{Mae-UAS.6.11}zpgLA00675 NA insertion of enhancer trap P{lacW}zpg3 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
exonuclease activity inferred from electronic annotation with InterPro:IPR006055 (FlyBase Curators et al., 2004-) nucleic acid binding inferred from electronic annotation with InterPro:IPR012337 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
intracellular inferred from electronic annotation with InterPro:IPR006055 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG8368 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Arf102F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Arf79F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Art8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG12079 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG12262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG12404 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG1416 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG1444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG1516 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG2021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG33303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG33926 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG4764 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG6453 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG7730 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - CG7911 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Chc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Cp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Droj2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - EfTuM anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Elongin-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Fatp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Fmr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Gfat2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Hsp68 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Kap-α3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - KdelR anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - ND75 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - NHP2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Prosα5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - RFeSP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rab1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rab2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rab39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rab5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Ranbp9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rap2l anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - RhoL anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - RpLP0 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rrp46 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Sc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - SdhB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Spt-I anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - dream anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - eIF-5A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - hyd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - l(1)G0320 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - mRpL39 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - mt:CoII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG8368 - sec63 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8368 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64190 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035707 DroID - A comprehensive database of gene and protein interactions. • FBgn0035707 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38740
Orthologs
OrthoDB Orthologs (38) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RJGM5 Dipteran inclusive ortholog search EOG6S1TGD Insect inclusive ortholog search EOG6XPP9Z Arthropod inclusive ortholog search EOG6NK99N Metazoa inclusive ortholog search EOG6GR2XZ
Orthologs in Drosophila Species (EOG6RJGM5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG8368     Drosophila simulans   Dsim\GD13963 Y   Drosophila sechellia   Dsec\GM14791 Y   Drosophila erecta   Dere\GG15351 Y   Drosophila yakuba   Dyak\GE21570 Y   Drosophila ananassae   Dana\GF23543 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21025 Y   Drosophila persimilis   Dper\GL13270 Y   Drosophila willistoni   Dwil\GK12547 Y   Drosophila virilis   Dvir\GJ13378 Y   Drosophila mojavensis   Dmoj\GI12104 Y   Drosophila grimshawi   Dgri\GH15165 Y
Orthologs in non-Drosophila Dipterans (EOG6S1TGD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL006744   Anopheles gambiae Malaria mosquito  Agam\AGAP005406   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010599
Orthologs in non-Dipteran Insects (EOG6XPP9Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB42159   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002141   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH18416   Atta cephalotes Leafcutter ant  Acep\ACEP10531   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16657   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23666   Linepithema humile Argentine ant  Lhum\LH16522   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22896   Solenopsis invicta Red fire ant  Sinv\SINV19500   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009265   Bombyx mori Silkmoth  Bmor\BGIBMGA011782   Pediculus humanus Human body louse  Phum\PHUM519520   Tribolium castaneum Red flour beetle  Tcas\TC003027
Orthologs in non-Insect Arthropods (EOG6NK99N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_326896   Daphnia pulex Water flea  Dpux\JGI_V11_227396   Ixodes scapularis Deer tick  Isca\ISCW000182
Orthologs in non-Arthropod Metazoa (EOG6GR2XZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C05C8.5   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011426gn   Xenopus tropicalis Western clawed frog  Xtro\loc81691   Gallus gallus Domestic chicken  Ggal\LOC427001   Mus musculus House mouse  Mmus\2610020H08Rik   Rattus norvegicus Norway rat  Rnor\Exnef   Homo sapiens Human  Hsap\ENSG00000005189
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000005189
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13963 Drosophila sechellia Dsec\GM14791 Drosophila erecta Dere\GG15351 Drosophila yakuba Dyak\GE21570 Drosophila ananassae Dana\GF23543 Drosophila pseudoobscura pseudoobscura Dpse\GA21025 Drosophila persimilis Dper\GL13270 Drosophila willistoni Dwil\GK12547 Drosophila virilis Dvir\GJ13378 Drosophila mojavensis Dmoj\GI12104 Drosophila grimshawi Dgri\GH15165
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	32931 y1 sc* v1; P{TRiP.HMS00724}attP2 42635 y1 sc* v1; P{TRiP.HMS02471}attP40 22247 y1 w67c23; P{Mae-UAS.6.11}zpgLA00675 CG8368LA00675/TM3, Sb1 Ser1
Harvard	- PBac{PB}CG8368c04255
Kyoto	120675 y* w*; P{Mae-UAS.6.11}zpgLA00675
VDRC	v108563 P{KK101144}VIE-260B v45259 w1118; P{GD13906}v45259
Genomic Clones ( 2 )
	BACR26E12 BACR26E20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 70 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD29573
Other clones	DPiM_LD29573
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08315 AT09468 AT09708 AT09742 AT11252 AT12142 AT12439 AT13239 AT13438 AT16412 AT16475 AT16507 AT17955 AT19729 AT22117 AT23001 AT24106 AT24167 AT25548 AT25558 AT25583 AT26514 AT26831 AT26915 AT30193 AT31055 AT31873 RE12804 RE21624 RE30282 RE30572 SD05518 SD15941
Other clones	176026 214435.80 214471.67 bs07c12 bs17g07 bs18d09 bs44a09 bs48g05 bs64g11 CK01.39D.E9 CK01.52A.F8 CK01.84D.E1 CK01.87B.G10 CK01.96B.H6 CK01731 Dmel_dig_020922_0680_0732 Dmel_neb_011109_0156_2338 Dmel_neb_011673_0341_3425 Dmel_neb_012109_0432_2055 Dmel_neb_012417_0449_1032 Dmel_neb_012595_0101_1652 Dmel_neb_012717_0172_1557 Dmel_neb_013404_0371_1614 Dmel_neb_013506_0381_2412 Dmel_neb_013723_0193_2863 Dmel_neb_013920_0391_1383 EK042256 EK067217 EK068959 EK189303 EP06235 EP22309 FGM230H01 IP10625 IP10725
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38740
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139793 NM_168172 RefSeq (Proteins) • NP_648050 NP_729177 DDBJ / EMBL / GenBank • AA141430 AA141431 AAF50654 AAN12085 AI944952 AI945868 AI945927 BF497840 CZ469115 CZ469116 Entrez Gene - A searchable database of RefSeq genes. • 38740 UniProtKB/TrEMBL • Q9VRX7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Exonuclease (IPR006055) Ribonuclease H-like domain (IPR012337) Exonuclease, RNase T/DNA polymerase III (IPR013520)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64190 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035707 DroID - A comprehensive database of gene and protein interactions. • FBgn0035707 DRSC - Results from RNAi screens. • FBgn0035707 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035707 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8368-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035707 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38740 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38740 modMine - Data generated by the modENCODE project. • FBgn0035707
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG8368 (FlyBase Curators, 2008, Shapira et al., 2011, Han et al., 2011, Keleman et al., 2009.8.5, Ni et al., 2010.12.1)
Name Synonym	RNase H-like (Tazuke et al., 2002)
Secondary FlyBase IDs
References ( 20 )
Research paper	Han et al., 2011, Curr. Biol. 21(22): 1878--1887 The 3'-to-5' Exoribonuclease Nibbler Shapes the 3' Ends of MicroRNAs Bound to Drosophila Argonaute1. [FBrf0216729] Shapira et al., 2011, Mol. Cell. Biol. 31(22): 4582--4592 The Drosophila javelin Gene Encodes a Novel Actin-Associated Protein Required for Actin Assembly in the Bristle. [FBrf0216490] Tazuke et al., 2002, Development 129(10): 2529--2539 A germline-specific gap junction protein required for survival of differentiating early germ cells. [FBrf0146994]
Supplementary material	Graveley et al., 2011, Nature 471(7339): Supplementary Table 29. Summary of A-to-I RNA Editing Sites Discovered. [FBrf0213715] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2010.12.1, A genome-scale shRNA resource for transgenic RNAi in Drosophila. A genome-scale shRNA resource for transgenic RNAi in Drosophila. [FBrf0212437] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping project DPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file) Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file) (Computer file) [FBrf0132177] Oliver, 2001.8.16, Genome Res.: File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file) Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Curated genome annotation	FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.] [Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]