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Gene Dmel\RpL18

General Information
Symbol	Dmel\RpL18	Species	D. melanogaster
Name	Ribosomal protein L18	Annotation symbol	CG8615
Feature type	protein_coding_gene	FlyBase ID	FBgn0035753
Gene Model Status	Current	Stock availability	4 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65E9-65E9	Sequence location	3L:7,233,294..7,234,449 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ribosomal protein L18 is referred to in FlyBase by the symbol Dmel\RpL18 (CG8615, FBgn0035753). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. There is experimental evidence that it is involved in the biological process: mitotic spindle elongation; mitotic spindle organization. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L18e; Ribosomal protein L18e, conserved site; Ribosomal protein L18e/L15P. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629400_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of RpL18. Gene sequence location is 3L:7233294..7234449.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Alonso and Santaren, 2006, J. Proteome Res. 5(8): 2025--2032 Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood ribosome day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA11016 BKN28218
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65E9-65E9   Limits computationally determined from genome sequence between P{PZ}corn04202 and P{lacW}Cdc27L7123
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\RpL18 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) RpL18-RA FBtr0076892  NM_139834   731   188
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein RpL18-PA   FBpp0076602   21.7   188   12.07     NP_648091   AAF50596
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L18e (IPR000039) Ribosomal protein L18e/L15P (IPR021131) Ribosomal protein L18e, conserved site (IPR021132)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA203047   AA203089   AA246670   AA263437   AA440778   AA695297   AA695830   AA695956   AA952224   AE014296 AAF50596   AI061970   AI062680   AI063700   AI063799   AI063874   AI064175   AI108112   AI108184   AI134097   AI134210   AI135303   AI135743   AI238166   AI258129   AI258573   AI259644   AI260016   AI260399   AI294659   AI296421   AI296944   AI387941   AI389196   AI390041   AI402092   AI403086   AI403544   AI403662   AI404515   AI404870   AI405140   AI405592   AI406057   AI455797   AI514286   AI515789   AI517814   AI532361   AI532907   AY113554 AAM29559   BG632009   BG632806   BG635481   BG635848   BG635977   BG636254   BG636715   BG636782   BG636828   BG637254   BG640678   BG640885   BG640929   BI142072   BI164446   BI165895   BI165956   BI169235   BI170636   BI171155   BI171904   BI172605   BI172777   BI212809   BI228010   BI229039   BI234580   BI235100   BI236575   BI237620   BI241525   BI241842   BI242054   BI242388   BI242733   BI351774   BI351893   BI353003   BI353902   BI354083   BI354576   BI354643   BI354661   BI354904   BI355177   BI355926   BI357023   BI357230   BI357543   BI357650   BI363696   BI365997   BI367498   BI367898   BI368880   BI370030   BI370654   BI372660   BI373602   BI374041   BI483927   BI484833   BI485306   BI485902   BI486135   BI486280   BI487233   BI487235   BI564315   BI564316   BI564512   BI564557   BI564663   BI564989   BI565111   BI566148   BI566196   BI566317   BI566494   BI566576   BI566661   BI566859   BI567391   BI567507   BI567763   BI567871   BI567878   BI567938   BI568325   BI568564   BI569390   BI569590   BI569687   BI569765   BI570301   BI570328   BI570493   BI571472   BI572270   BI575268   BI575506   BI575707   BI576006   BI581163   BI581240   BI581381   BI581562   BI581656   BI581818   BI581986   BI583039   BI583116   BI583123   BI583186   BI583494   BI583564   BI583655   BI583707   BI584004   BI584738   BI584965   BI585034   BI585231   BI585395   BI585473   BI585550   BI586146   BI586587   BI587446   BI587498   BI587796   BI588072   BI588199   BI588440   BI589225   BI589268   BI589993   BI589998   BI590246   BI590265   BI591329   BI591955   BI592052   BI592420   BI592604   BI592971   BI593036   BI604416   BI604727   BI604728   BI606006   BI606099   BI606423   BI606555   BI606705   BI607323   BI607455   BI607507   BI607626   BI607812   BI608025   BI608474   BI608949   BI609981   BI610285   BI611090   BI611231   BI611332   BI611369   BI612137   BI612390   BI612411   BI612675   BI612714   BI612883   BI613613   BI614740   BI614748   BI614783   BI614950   BI614957   BI615060   BI615216   BI615235   BI615322   BI616396   BI616458   BI616576   BI616648   BI616819   BI616828   BI616877   BI617147   BI617472   BI617983   BI618102   BI618255   BI618430   BI618680   BI618877   BI619086   BI619494   BI620223   BI620585   BI620803   BI621020   BI621254   BI621564   BI621813   BI622126   BI622547   BI622723   BI622823   BI622931   BI623350   BI624017   BI624200   BI625289   BI625293   BI626049   BI626193   BI626539   BI626546   BI627005   BI627020   BI627565   BI627952   BI627975   BI628474   BI628854   BI629537   BI629679   BI629750   BI629897   BI630263   BI630485   BI630525   BI630579   BI630635   BI630646   BI630816   BI631133   BI631320   BI631527   BI634085   BI634163   BI634496   BI638462   BP549434   BP550160   BP550161   BP550471   BP550785   BP551691   BP551986   BP552251   BP552727   BP553808   BP556059   BP560378   BQ102719   BQ102771   BQ103059   BQ103387   BT030448   CA804524   CK131906   CK131922   CK604429   CK604430   CK605080   CK605081   CK657458   CK657885   CK658007   CK658378   CK660237   CK660881   CO153777   CO155448   CO177580   CO181669   CO181764   CO187646   CO196023   CO263377   CO267211   CO267958   CO281022   CO282896   CO294621   CO296755   CO317763   CO335942   CO336105   CO336474   CO336580   CO336847   CO336896   CO337385   CO337483   CO338340   CO338786   CO339130   EC053278   EC057631   EC059533   EC063916   EC084402   EC089574   EC208241   EC220042   EC222819   EC228517   EC230071   EC233641   EC242708   EC245496   EC259995   EC261496   EC263311   EC263384   EC263876   EC265312   EC265355   EC265966   EC266002   EC266016   EC266110   EC267745   EL870380   EL870382   EL871615   EL871990   EL872994   EL873085   EL873166   EL873167   EL873265   EL879065   EL881650   EL881839   EL881950   EL882183   EL882289   EV575391   EV575611   EV576301   EV576316   EV578524   EV578778   EV579371   EV579611   EV579854   EV580240   EV581330   EV581395   EV581686   EV584579   EV584661   EV586172   EV586380   EV589498   EV589694   EV591972   EV592769   EV594549   EV595012   EV595516   EV595536   EV597029   EV597966   EV598071   EV598264   EV598529   EV599001   EV600148   EV600223   EV600357   EV600651   GH748121   GH748960   GH750207   GH753672   GH755950   GH760664   GH761128   GH770773   GH771961   GH777828   GH778687   GH780603   GH780998   GH781598   GH781880   GH782172   GH783366   GH784692   GH788154   GH788953   GH789444   GH789560   GH790222   GH791166   GH792446   GH793762   GH794426   GH795217   GH795398   GH796244   GH796742   GH798630   GH799050   GH806855   GH810678   GH810833   GH816143   GH816805   GH817559   GH817614   GH818509   GH819914   GH820044   GH820422   GH820745   GH823939   GH824151   GH827273   GH828289   GH828427   GH831118   GH832178   GH834035   GH835145   GH839846   GH843545   GH845175   GH845784   GH847281   GH849226   GH849888   GH851286   GH851448   GH851630   GH851922   GH853613   GH855668   GH856847   GH859727   GH861036   GH862581   GH862976   GH866194   GH867156   GH867931   GH869081   GH870402   GH871308   GH875585   GH875970   GH879109   GH880506   GH880546   GH880917   GH884518   GH885189   GH885793   GH885805   GH886390   GH886594   GH888717   GH889484   GH894040   GH894960   GH895196   GH898148   GH900635   GH901793   GH902166   GH902660   GH904589   GH905736   GH907771   GH910415   GH911766   GH911796   GH912752   GH914892   GH915279   GH917784   GH917824   GH918011   GH918152   GH923114   GH924095   GH924712   GH926092   GH926472   GH927712   GH929466   GH934080   GH934792   GH938015   GH938561
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VS34
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035753    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035753 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035753 expression level Developmental Stage   Expression Level embryo 00-02hr    126927 embryo 02-04hr    179711 embryo 04-06hr    143365 embryo 06-08hr    171191 embryo 08-10hr    165054 embryo 10-12hr    176111 embryo 12-14hr    108021 embryo 14-16hr    162014 embryo 16-18hr    128695 embryo 18-20hr    177397 embryo 20-22hr    182620 embryo 22-24hr    121592 larva L1    203342 larva L2    149850 larva L3 12hr old    143821 larva L3 puffstage 1-2    104894 larva L3 puffstage 3-6    112221 larva L3 puffstage 7-9    100703 white prepupae new    86476 white prepupae 12hr    76686 white prepupae 24hr    77479 pupae 2d postWPP    63956 pupae 3d postWPP    50765 pupae 4d postWPP    70530 adult male 01day    49815 adult male 05day    59857 adult male 30day    65636 adult female 01day    133679 adult female 05day    120932 adult female 30day    142413 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (126927) embryo 02-04hr  (179711) embryo 04-06hr  (143365) embryo 06-08hr  (171191) embryo 08-10hr  (165054) embryo 10-12hr  (176111) embryo 12-14hr  (108021) embryo 14-16hr  (162014) embryo 16-18hr  (128695) embryo 18-20hr  (177397) embryo 20-22hr  (182620) embryo 22-24hr  (121592) larva L1  (203342) larva L2  (149850) larva L3 12hr old  (143821) larva L3 puffstage 1-2  (104894) larva L3 puffstage 3-6  (112221) larva L3 puffstage 7-9  (100703) white prepupae new  (86476) white prepupae 12hr  (76686) white prepupae 24hr  (77479) pupae 2d postWPP  (63956) pupae 3d postWPP  (50765) pupae 4d postWPP  (70530) adult male 01day  (49815) adult male 05day  (59857) adult male 30day  (65636) adult female 01day  (133679) adult female 05day  (120932) adult female 30day  (142413) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (126927) embryo 02-04hr  (179711) embryo 04-06hr  (143365) embryo 06-08hr  (171191) embryo 08-10hr  (165054) embryo 10-12hr  (176111) embryo 12-14hr  (108021) embryo 14-16hr  (162014) embryo 16-18hr  (128695) embryo 18-20hr  (177397) embryo 20-22hr  (182620) embryo 22-24hr  (121592) larva L1  (203342) larva L2  (149850) larva L3 12hr old  (143821) larva L3 puffstage 1-2  (104894) larva L3 puffstage 3-6  (112221) larva L3 puffstage 7-9  (100703) white prepupae new  (86476) white prepupae 12hr  (76686) white prepupae 24hr  (77479) pupae 2d postWPP  (63956) pupae 3d postWPP  (50765) pupae 4d postWPP  (70530) adult male 01day  (49815) adult male 05day  (59857) adult male 30day  (65636) adult female 01day  (133679) adult female 05day  (120932) adult female 30day  (142413) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (126927) embryo 02-04hr  (179711) embryo 04-06hr  (143365) embryo 06-08hr  (171191) embryo 08-10hr  (165054) embryo 10-12hr  (176111) embryo 12-14hr  (108021) embryo 14-16hr  (162014) embryo 16-18hr  (128695) embryo 18-20hr  (177397) embryo 20-22hr  (182620) embryo 22-24hr  (121592) larva L1  (203342) larva L2  (149850) larva L3 12hr old  (143821) larva L3 puffstage 1-2  (104894) larva L3 puffstage 3-6  (112221) larva L3 puffstage 7-9  (100703) white prepupae new  (86476) white prepupae 12hr  (76686) white prepupae 24hr  (77479) pupae 2d postWPP  (63956) pupae 3d postWPP  (50765) pupae 4d postWPP  (70530) adult male 01day  (49815) adult male 05day  (59857) adult male 30day  (65636) adult female 01day  (133679) adult female 05day  (120932) adult female 30day  (142413) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    126927 embryo 02-04hr    179711 embryo 04-06hr    143365 embryo 06-08hr    171191 embryo 08-10hr    165054 embryo 10-12hr    176111 embryo 12-14hr    108021 embryo 14-16hr    162014 embryo 16-18hr    128695 embryo 18-20hr    177397 embryo 20-22hr    182620 embryo 22-24hr    121592 larva L1    203342 larva L2    149850 larva L3 12hr old    143821 larva L3 puffstage 1-2    104894 larva L3 puffstage 3-6    112221 larva L3 puffstage 7-9    100703 white prepupae new    86476 white prepupae 12hr    76686 white prepupae 24hr    77479 pupae 2d postWPP    63956 pupae 3d postWPP    50765 pupae 4d postWPP    70530 adult male 01day    49815 adult male 05day    59857 adult male 30day    65636 adult female 01day    133679 adult female 05day    120932 adult female 30day    142413 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035753 expression level Developmental Stage   Expression Level embryo 00-02hr    126927 embryo 02-04hr    179711 embryo 04-06hr    143365 embryo 06-08hr    171191 embryo 08-10hr    165054 embryo 10-12hr    176111 embryo 12-14hr    108021 embryo 14-16hr    162014 embryo 16-18hr    128695 embryo 18-20hr    177397 embryo 20-22hr    182620 embryo 22-24hr    121592 larva L1    203342 larva L2    149850 larva L3 12hr old    143821 larva L3 puffstage 1-2    104894 larva L3 puffstage 3-6    112221 larva L3 puffstage 7-9    100703 white prepupae new    86476 white prepupae 12hr    76686 white prepupae 24hr    77479 pupae 2d postWPP    63956 pupae 3d postWPP    50765 pupae 4d postWPP    70530 adult male 01day    49815 adult male 05day    59857 adult male 30day    65636 adult female 01day    133679 adult female 05day    120932 adult female 30day    142413 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (126927) embryo 02-04hr  (179711) embryo 04-06hr  (143365) embryo 06-08hr  (171191) embryo 08-10hr  (165054) embryo 10-12hr  (176111) embryo 12-14hr  (108021) embryo 14-16hr  (162014) embryo 16-18hr  (128695) embryo 18-20hr  (177397) embryo 20-22hr  (182620) embryo 22-24hr  (121592) larva L1  (203342) larva L2  (149850) larva L3 12hr old  (143821) larva L3 puffstage 1-2  (104894) larva L3 puffstage 3-6  (112221) larva L3 puffstage 7-9  (100703) white prepupae new  (86476) white prepupae 12hr  (76686) white prepupae 24hr  (77479) pupae 2d postWPP  (63956) pupae 3d postWPP  (50765) pupae 4d postWPP  (70530) adult male 01day  (49815) adult male 05day  (59857) adult male 30day  (65636) adult female 01day  (133679) adult female 05day  (120932) adult female 30day  (142413) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (126927) embryo 02-04hr  (179711) embryo 04-06hr  (143365) embryo 06-08hr  (171191) embryo 08-10hr  (165054) embryo 10-12hr  (176111) embryo 12-14hr  (108021) embryo 14-16hr  (162014) embryo 16-18hr  (128695) embryo 18-20hr  (177397) embryo 20-22hr  (182620) embryo 22-24hr  (121592) larva L1  (203342) larva L2  (149850) larva L3 12hr old  (143821) larva L3 puffstage 1-2  (104894) larva L3 puffstage 3-6  (112221) larva L3 puffstage 7-9  (100703) white prepupae new  (86476) white prepupae 12hr  (76686) white prepupae 24hr  (77479) pupae 2d postWPP  (63956) pupae 3d postWPP  (50765) pupae 4d postWPP  (70530) adult male 01day  (49815) adult male 05day  (59857) adult male 30day  (65636) adult female 01day  (133679) adult female 05day  (120932) adult female 30day  (142413) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (126927) embryo 02-04hr  (179711) embryo 04-06hr  (143365) embryo 06-08hr  (171191) embryo 08-10hr  (165054) embryo 10-12hr  (176111) embryo 12-14hr  (108021) embryo 14-16hr  (162014) embryo 16-18hr  (128695) embryo 18-20hr  (177397) embryo 20-22hr  (182620) embryo 22-24hr  (121592) larva L1  (203342) larva L2  (149850) larva L3 12hr old  (143821) larva L3 puffstage 1-2  (104894) larva L3 puffstage 3-6  (112221) larva L3 puffstage 7-9  (100703) white prepupae new  (86476) white prepupae 12hr  (76686) white prepupae 24hr  (77479) pupae 2d postWPP  (63956) pupae 3d postWPP  (50765) pupae 4d postWPP  (70530) adult male 01day  (49815) adult male 05day  (59857) adult male 30day  (65636) adult female 01day  (133679) adult female 05day  (120932) adult female 30day  (142413) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    126927 embryo 02-04hr    179711 embryo 04-06hr    143365 embryo 06-08hr    171191 embryo 08-10hr    165054 embryo 10-12hr    176111 embryo 12-14hr    108021 embryo 14-16hr    162014 embryo 16-18hr    128695 embryo 18-20hr    177397 embryo 20-22hr    182620 embryo 22-24hr    121592 larva L1    203342 larva L2    149850 larva L3 12hr old    143821 larva L3 puffstage 1-2    104894 larva L3 puffstage 3-6    112221 larva L3 puffstage 7-9    100703 white prepupae new    86476 white prepupae 12hr    76686 white prepupae 24hr    77479 pupae 2d postWPP    63956 pupae 3d postWPP    50765 pupae 4d postWPP    70530 adult male 01day    49815 adult male 05day    59857 adult male 30day    65636 adult female 01day    133679 adult female 05day    120932 adult female 30day    142413 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035753    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035753 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035753 expression level Tissue   Expression Level Larval Central Nervous System    2522.075 Larval Midgut    4052.8 Larval Hindgut    3896.1 Larval Malpighian Tubules    3835.4 Larval Fat Body    6804.8 Larval Salivary Gland    6378.8 Larval Trachea    4938.525 Larval Carcass    4296.65 Adult Head    4024.4 Adult Eye    4418.325 Adult Brain    2596.1 Adult Thoracic-Abdominal Ganglion    3241.3 Adult Crop    4709.5 Adult Midgut    4673.3 Adult Hindgut    4305.2 Adult Malpighian Tubules    3110.4 Adult Fat Body    5199.4 Adult Salivary Gland    6865.8 Adult Heart    4980 Adult VirginFemale Spermatheca    4401.3 Adult InseminatedFemale Spermatheca    4544.3 Adult Ovary    3075.9 Adult Testis    779.2 Adult Male Accessory Gland    7302.5 Adult Carcass    4791 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2522.075) Larval Midgut  (4052.8) Larval Hindgut  (3896.1) Larval Malpighian Tubules  (3835.4) Larval Fat Body  (6804.8) Larval Salivary Gland  (6378.8) Larval Trachea  (4938.525) Larval Carcass  (4296.65) Adult Head  (4024.4) Adult Eye  (4418.325) Adult Brain  (2596.1) Adult Thoracic-Abdominal Ganglion  (3241.3) Adult Crop  (4709.5) Adult Midgut  (4673.3) Adult Hindgut  (4305.2) Adult Malpighian Tubules  (3110.4) Adult Fat Body  (5199.4) Adult Salivary Gland  (6865.8) Adult Heart  (4980) Adult VirginFemale Spermatheca  (4401.3) Adult InseminatedFemale Spermatheca  (4544.3) Adult Ovary  (3075.9) Adult Testis  (779.2) Adult Male Accessory Gland  (7302.5) Adult Carcass  (4791) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2522.075) Larval Midgut  (4052.8) Larval Hindgut  (3896.1) Larval Malpighian Tubules  (3835.4) Larval Fat Body  (6804.8) Larval Salivary Gland  (6378.8) Larval Trachea  (4938.525) Larval Carcass  (4296.65) Adult Head  (4024.4) Adult Eye  (4418.325) Adult Brain  (2596.1) Adult Thoracic-Abdominal Ganglion  (3241.3) Adult Crop  (4709.5) Adult Midgut  (4673.3) Adult Hindgut  (4305.2) Adult Malpighian Tubules  (3110.4) Adult Fat Body  (5199.4) Adult Salivary Gland  (6865.8) Adult Heart  (4980) Adult VirginFemale Spermatheca  (4401.3) Adult InseminatedFemale Spermatheca  (4544.3) Adult Ovary  (3075.9) Adult Testis    779.2 Adult Male Accessory Gland  (7302.5) Adult Carcass  (4791) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2522.075 Larval Midgut    4052.8 Larval Hindgut    3896.1 Larval Malpighian Tubules    3835.4 Larval Fat Body    6804.8 Larval Salivary Gland    6378.8 Larval Trachea    4938.525 Larval Carcass    4296.65 Adult Head    4024.4 Adult Eye    4418.325 Adult Brain    2596.1 Adult Thoracic-Abdominal Ganglion    3241.3 Adult Crop    4709.5 Adult Midgut    4673.3 Adult Hindgut    4305.2 Adult Malpighian Tubules    3110.4 Adult Fat Body    5199.4 Adult Salivary Gland    6865.8 Adult Heart    4980 Adult VirginFemale Spermatheca    4401.3 Adult InseminatedFemale Spermatheca    4544.3 Adult Ovary    3075.9 Adult Testis    779.2 Adult Male Accessory Gland    7302.5 Adult Carcass    4791 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035753 expression level Tissue   Expression Level Larval Central Nervous System    2522.075 Larval Midgut    4052.8 Larval Hindgut    3896.1 Larval Malpighian Tubules    3835.4 Larval Fat Body    6804.8 Larval Salivary Gland    6378.8 Larval Trachea    4938.525 Larval Carcass    4296.65 Adult Head    4024.4 Adult Eye    4418.325 Adult Brain    2596.1 Adult Thoracic-Abdominal Ganglion    3241.3 Adult Crop    4709.5 Adult Midgut    4673.3 Adult Hindgut    4305.2 Adult Malpighian Tubules    3110.4 Adult Fat Body    5199.4 Adult Salivary Gland    6865.8 Adult Heart    4980 Adult VirginFemale Spermatheca    4401.3 Adult InseminatedFemale Spermatheca    4544.3 Adult Ovary    3075.9 Adult Testis    779.2 Adult Male Accessory Gland    7302.5 Adult Carcass    4791 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2522.075) Larval Midgut  (4052.8) Larval Hindgut  (3896.1) Larval Malpighian Tubules  (3835.4) Larval Fat Body  (6804.8) Larval Salivary Gland  (6378.8) Larval Trachea  (4938.525) Larval Carcass  (4296.65) Adult Head  (4024.4) Adult Eye  (4418.325) Adult Brain  (2596.1) Adult Thoracic-Abdominal Ganglion  (3241.3) Adult Crop  (4709.5) Adult Midgut  (4673.3) Adult Hindgut  (4305.2) Adult Malpighian Tubules  (3110.4) Adult Fat Body  (5199.4) Adult Salivary Gland  (6865.8) Adult Heart  (4980) Adult VirginFemale Spermatheca  (4401.3) Adult InseminatedFemale Spermatheca  (4544.3) Adult Ovary  (3075.9) Adult Testis  779.2 Adult Male Accessory Gland  (7302.5) Adult Carcass  (4791) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2522.075) Larval Midgut  (4052.8) Larval Hindgut  (3896.1) Larval Malpighian Tubules  (3835.4) Larval Fat Body  (6804.8) Larval Salivary Gland  (6378.8) Larval Trachea  (4938.525) Larval Carcass  (4296.65) Adult Head  (4024.4) Adult Eye  (4418.325) Adult Brain  (2596.1) Adult Thoracic-Abdominal Ganglion  (3241.3) Adult Crop  (4709.5) Adult Midgut  (4673.3) Adult Hindgut  (4305.2) Adult Malpighian Tubules  (3110.4) Adult Fat Body  (5199.4) Adult Salivary Gland  (6865.8) Adult Heart  (4980) Adult VirginFemale Spermatheca  (4401.3) Adult InseminatedFemale Spermatheca  (4544.3) Adult Ovary  (3075.9) Adult Testis    779.2 Adult Male Accessory Gland  (7302.5) Adult Carcass  (4791) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2522.075 Larval Midgut    4052.8 Larval Hindgut    3896.1 Larval Malpighian Tubules    3835.4 Larval Fat Body    6804.8 Larval Salivary Gland    6378.8 Larval Trachea    4938.525 Larval Carcass    4296.65 Adult Head    4024.4 Adult Eye    4418.325 Adult Brain    2596.1 Adult Thoracic-Abdominal Ganglion    3241.3 Adult Crop    4709.5 Adult Midgut    4673.3 Adult Hindgut    4305.2 Adult Malpighian Tubules    3110.4 Adult Fat Body    5199.4 Adult Salivary Gland    6865.8 Adult Heart    4980 Adult VirginFemale Spermatheca    4401.3 Adult InseminatedFemale Spermatheca    4544.3 Adult Ovary    3075.9 Adult Testis    779.2 Adult Male Accessory Gland    7302.5 Adult Carcass    4791 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4024.4   NA  Eye    4418.325   NA  Brain    2596.1   2522.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3241.3   NA  Crop    4709.5   4052.8  Midgut    4673.3   3896.1  Hindgut    4305.2   3835.4  Malpighian Tubules    3110.4   6804.8  Fat Body    5199.4   6378.8  Salivary Gland    6865.8   NA  Heart    4980   4938.525  Trachea    NA   NA  VirginFemale Spermatheca    4401.3   NA  InseminatedFemale Spermatheca    4544.3   NA  Ovary    3075.9   NA  Testis    779.2   NA  Male Accessory Gland    7302.5   4296.65  Carcass    4791 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_22
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035753 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8615-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 RpL18GD13989 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of RpL18 Class Mutagen Stocks Known lesion RpL18DG02805 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of RpL18 Class Mutagen Stocks Known lesion RpL18GD13989 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RpL18KK108218 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6111 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13989} NA P{KK108218} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}RpL18DG02805 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007)
Cellular Component
CV term Evidence References
ribosome inferred from direct assay (Alonso and Santaren, 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with UniProtKB:P12001 (FlyBase, 1992-)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with UniProtKB:P12001 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
cytosolic large ribosomal subunit inferred from sequence or structural similarity with UniProtKB:P12001 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions RpL18 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64237 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035753 DroID - A comprehensive database of gene and protein interactions. • FBgn0035753 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38794
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24783 Dere\GG14989 Dgri\GH15152 Dmoj\GI12089 Dper\GL24902 Dpse\GA21210 Dsec\GM13785 Dsim\GD13082 Dvir\GJ13360 Dwil\GK13159 Dyak\GE20435
Curated drosophilid orthologs	Dpse\GA21210
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008481-PA Aedes aegypti (mosquito) AGAP007580-PB Anopheles gambiae (mosquito) XP_392565.1 Apis mellifera (honey bee) XP_001948546.1 Acyrthosiphon pisum (pea aphid) At3g05590.1 Arabidopsis thaliana (wall cress) 87003 Batrachochytrium dendrobatidis (chytrid fungus) 275280 Branchiostoma floridae (lancelet) 61894 Branchiostoma floridae (lancelet) XP_001897286.1 Brugia malayi (roundworm nematode) BGIBMGA011620-PA Bombyx mori (silk worm) ENSBTAP00000020452 Bos taurus (bovine) CAL0003449 Candida albicans (a form of yeast) CN10002 Caenorhabditis brenneri (small nematode) CBP12125 Caenorhabditis briggsae (nematode) CE16650 Caenorhabditis elegans (worm) ENSCAFP00000005899 Canis familiaris (dog) CAGL0E02013g Candida glabrata (haploid yeast) Chro.40062 Cryptosporidium hominis (obligate parasite) ENSCINP00000024062 Ciona intestinalis (sea squirt) JA18791 Caenorhabditis japonica (nematode) CMB018C Cyanidioschyzon merolae (red alga) cn04293 Cryptococcus neoformans (yeast-like fungus) cgd4_470 Cryptosporidium parvum (protozoan parasite) CPIJ000205 Culex pipens (mosquito) ENSCPOP00000019149 Cavia porcellus (guinea pig) 144684 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000011287 Ciona savignyi (sedentary tunicate) 159560 Capitella spl (polychaete worm) DDB0229960 Dictyostelium discoideum (amoeba) DEHA2F16566g Debaryomyces Hansenii (yeast) 303528 Daphnia pulex (daphnia) ENSDARP00000043172 Danio rerio (zebra fish) ENSECAP00000019435 Equus caballus (horse) XP_649082 Entamoeba histolytica (anaerobic protozoan) XP_654919 Entamoeba histolytica (anaerobic protozoan) XP_656024 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015306 Gymnopilus aculeatus (mushroom) GL50803_11950 Giardia lamblia (flagellated protozoan) 156470 Hypsipyla robusta (cedar shoot borer) ENSP00000084795 Homo sapiens (human) ISCW021924-PA Ixodes scapularis (deer tick) KLLA0A07227g Kluyveromyces lactis (yeast) 205248 Lottia gigantea (owl limpet) LmjF13.0560 Leishmania major (virus) LmjF36.4510 Leishmania major (virus) 20935 Monocosta brevicollis (choanoflagellate) ENSMODP00000017629 Monodelphis domestica (gray opossum) ENSMMUP00000029169 Macaca mulatta (rhesus monkey) ENSMMUP00000032947 Macaca mulatta (rhesus monkey) ENSMMUP00000033712 Macaca mulatta (rhesus monkey) ENSMUSP00000103365 Mus musculus (house mouse) 236404 Nematostella vectensis (starlet anemone) XP_001607758.1 Nasonia vitripennis (wasp) ENSORLP00000013731 Oryzias latipes (japanese killifish) LOC_Os05g06310.1 Oryza sativa (asian rice) 26333 Ostreococcus tauri (green alga) MAL13P1.209 Plasmodium falciparum (protozoal parasite) PHUM000951-PA Pediculus humanus (human body louse) PP13042 Pristionchus pacificus (nematode) 162579 Physcomitrella patens (moss) ENSPPYP00000011412 Pongo pygmaeus (orangutan) 74564 Phytophthora ramorum (sudden oak death pathogen) 115505 Phytophthora sojae (root rot pathogen) 552462 Populus trichocarpa (black cottonwood) ENSPTRP00000019289 Pan troglodytes (chimpanzee) PVX_082970 Plasmodium vivax (protozoal parasite) ENSRNOP00000028555 Rattus norvegicus (norway rat) 4876869 Sorghum bicolor (sorghum) YNL301C Saccharomyces cerevisiae (budding yeast) YOL120C Saccharomyces cerevisiae (budding yeast) Smp_031570 Schistosoma mansoni (trematode parasite) SPAPB17E12.13 Schizosaccharomyces pombe (fission yeast) XP_001191566.1 Strongylocentrotus purpuratus (purple sea urchin) 52962 Trichoplax adhaerens (metazoa) TA15200 Theileria annulata (apicomplexan parasite) XP_968042.1 Tribolium castaneum (red flour beetle) Tc00.1047053503395.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053504147.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506181.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010901 Tetraodon nigroviridis (green spotted pufferfish) TP02_0801 Theileria parva (parasitic protozoan) 41319 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039889 Takifugu rubripes (pufferfish Takifugu) 3711.m00085 Tetrahymena thermophila (ciliate protozoa) 88439.m00044 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006884 Xenopus tropicalis (frog) YALI0B08866g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13795 NV13677 LH24399 RL18_IXOSC FBgn0237750 FBgn0215168 FBgn0200585 FBgn0184804 FBgn0168716 JGI_V11_303528 FBgn0249124 FBgn0081198 FBgn0162489 FBgn0150819 FBgn0134846 FBgn0122627 FBgn0107243 FBgn0101776 CPIJ000205 BGIBMGA011620 ACYPI006857 GB11029 RL18_ANOGA RL18_AEDAE PHUM042190 GLEAN_03672
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	20574 y1 w67c23; P{wHy}RpL18DG02805/TM3, Sb1 Ser1
VDRC	v108257 P{KK108218}VIE-260B v42149 w1118; P{GD13989}v42149 v42152 w1118; P{GD13989}v42152
Genomic Clones ( 1 )
	BACR16I16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 545 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH01814
Other clones	IP16807
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01324 GH01970 GH03656 GH03779 GH03979 GH04455 GH06854 GH06954 GH07651 GH11456 GH11604 GH12982 GH13604 GH14167 GH14219 GH18647 GH20312 GH21492 GH23010 GH24256 GH24718 GH25065 GH25647 GH26243 GH27384 GH28877 GM02557 GM04559 GM04829 GM16079 GM16592 GM21759 GM25535 GM26213 GM27463 GM27720 GM27783 GM28768 GM29751 LD29327 LD35491 LD41460 LP01244 LP03111 LP03672 LP08080 LP10295 LP11070 LP12479 LP12973 LP14483 LP15260 LP18634 LP19824 LP23775 RE12156 RE15450 RE29119 RE33871 RE39694 RH03538 RH05081 RH09530 RH09656 RH10816 RH13026 RH15404 RH17208 RH17410 RH17568 RH22374 RH24463 RH25156 RH28126 RH29319 RH40542 RH41658 RH41872 RH44201 RH44210 RH44250 RH44461 RH44928 RH46585 RH46908 RH47001 RH47384 RH47821 RH48645 RH48860 RH51308 RH52301 RH53229 RH54440 RH54636 RH56390 RH57614 RH58421 RH58581 RH58834 RH59851 RH59928 RH60126 RH60547 RH61116 RH62594 RH65609 RH69759 RH72192 RH73095 RH73352 RH74528 RH74586 RH74728 SD03853 SD04556 SD11817 SD12053 SD12113 SD12894 SD13348 SD13528 SD13879 SD14484 SD14567 SD14626 SD15159 SD16069 SD20755
Other clones	34241 37548 45589 53237 75394 164455 214219.60 524865 542877 557008 557889 558008 561909 561955 569044 569151 571294 575655 CK01.36B.C10 CK01.66B.C4 CK01.105D.F10 CK01.111A.D11 CK01.118A.H4 CK01.124C.E1 Dmel_dig_002112_0638_0450 Dmel_dig_003513_0653_0352 Dmel_dig_005338_0685_2744 Dmel_dig_005475_0679_1642 Dmel_dig_005751_0666_0985 Dmel_dig_008750_0624_1548 Dmel_dig_009975_0710_1345 Dmel_dig_010983_0608_0606 Dmel_dig_013274_0668_1748 Dmel_dig_013515_0619_0552 Dmel_dig_013596_0608_1361 Dmel_dig_014321_0669_0840 Dmel_dig_014337_0602_2155 Dmel_dig_014874_0691_2411 Dmel_dig_015954_0669_1590 Dmel_dig_016790_0582_2942 Dmel_neb_007068_0633_1623 Dmel_neb_009880_0362_3559 Dmel_neb_010877_0666_2823 Dmel_neb_011248_0640_2091 Dmel_neb_013088_0154_2977 Dmel_neb_013201_0939_1701 Dmel_neb_013316_0872_2080 Dmel_neb_013560_0945_1306 Dmel_neb_014365_0941_0583 Dmel_neb_014544_0938_1336 Dmel_neb_014692_0878_0809 Dmel_neb_014725_0870_3535 Dmel_neb_014764_0855_1586 Dmel_neb_014780_0567_3510 Dmel_neb_015151_0329_1371 Dmel_neb_015379_0628_1729 Dmel_neb_015549_0881_1174 Dmel_neb_015680_0685_3391 Dmel_neb_016267_0931_1277 EC14815 EC14944 EK000215 EK031032 EK053842 EK088355 EK089747 EK149119 EK155742 EK161726 EK207315 EK215107 EK269025 EN02807 EN06051 EN11530 EN11841 EN12614 EN12823 EN13347 EN13439 EN14428 EN14633 EN16536 EN17612 EP00925 ESG0114a.B21_C02 FGM101E03 FGM105F03 FGM207C12 FGM209B02 FGM214C05 FGM216A01 FGM217F11 FGM220D09 FGM226D07 FGM301B08 FGX001F11 GH22451 GH23147 IP02478 IP02479 IP03693 IP03993 IP04813 IP04913 IP05013 IP05113 IP09006 IP11448 IP11655 IP11755 IP11955 IP12070 LD03541 LD03589 LD05583 LD07252 LD15652 LD35082 LP01796 LP04223 LP13012 RE04123 RE05886 RE05960 RE10347 RE12848 RE13802 RE15138 RE18048 RE25420 RE26736 RE30304 RE30909 RE32646 RE38615 RE39028 RE39270 RE40143 RE43362 RE43650 RE44057 RE44180 RE48619 RE51419 RE53272 RE53768 RE54934 RE56393 RE57362 RE59675 RE60938 RE61551 RE66891 RE67991 RE68614 RE69257 RE69514 RE69691 RE70755 RE70757 RH01472 RH01689 RH01914 RH02604 RH02635 RH02837 RH03533 RH03838 RH03859 RH06603 RH07746 RH10102 RH10343 RH10910 RH11760 RH12153 RH13669 RH14841 RH17529 RH18503 RH18606 RH18766 RH19072 RH19187 RH19627 RH19847 RH21472 RH21575 RH21584 RH21723 RH22122 RH22211 RH22318 RH22751 RH24008 RH24320 RH24805 RH24945 RH25064 RH25950 RH26657 RH28185 RH28671 RH29084 RH29673 RH30524 RH31193 RH31589 RH31650 RH32001 RH32457 RH35308 RH35372 RH35529 RH36056 RH36259 RH36369 RH36628 RH37204 RH37205 RH37292 RH37383 RH37760 RH37918 RH38340 RH38574 RH38581 RH38666 RH39252 RH39748 RH40155 RH40844 RH40870 RH41615 RH42812 RH44453 RH44581 RH44792 RH44818 RH46331 RH46414 RH46689 RH46917 RH48484 RH49183 RH49560 RH49815 RH50056 RH50539 RH51762 RH52028 RH52567 RH52924 RH53950 RH54746 RH54971 RH55488 RH56895 RH58659 RH59268 RH59538 RH59586 RH59916 RH60874 RH61814 RH61859 RH62021 RH62795 RH63721 RH65614 RH66577 RH66747 RH67514 RH67523 RH68178 RH68202 RH68914 RH69457 RH69484 RH70180 RH70181 RH72070 RH72895 RH74368 RP003004046 RP003013978 RP003015511 RP003017021 RP003019066 RP003026763 RP003041108 RP003046225 RP003050873 RP003053104 RP003054505 RP003077289 RP003079801 RP003083403 RP003087008 RP003090737 RP003091406 RP003098647 RP003103173 RP003124476 RP003132870 RP003135287 RP003146337 RP003164647 RP003166378 RP003172716 RP003173336 RP003178166 RP003179698 RP003189134 RP003191738 RP003193904 RP003194682 RP003201310 RP003203745 RP003204625 RP003219957 RP003223206 RP003223245 RP003226913 RP003228320 RP003228435 RP003231736 RP003235380 RP003238217 RP003239079 RP003245973 RP003254447 RP003264354 RP003264547 RP003264905 RP003269370 RP003270753 RP003271492 RP003278815 RP003279020 RP003279834 RP003284264 RP003296086 RP003312288 RP003320937 RP003322051 RP003326349 RP003331960 RP003333865 RP003339612 RP003344663 RP003345775 RP003350062 RP003356003 RP003357067 RP003359234 RP003381441 RP003382782 RP003383859 RP003386464 RP003389124 RP003394553 RP003401963 RP003413571 RP003416985 RP003421284 RP003426150 RP003438836 RP003441938 RP003449806 RP003464165 RP003468076 RP003471342 RP003479289 RP003480031 RP003491820 RP003496116 RP003497363 RP003504734 RP003510784 RP003514759 RP003517515 RP003520611 RP003527700 RP003529146 RP003530067 RP003531170 RP003542170 RP003545196 RP003561399 RP003562225 RP003568081 RP003568691 RP003573508 RP003578286 RP003579519 RP003584733 RP003601497 RP003602882 RP003608816 RP003616803 RP003623194 RP003634829 RP003641006 RP003643705 RP003662316 RP003674395 RP003679383 UT01179 UT01661 UUGC0158 UUGC0455 UUGC0791
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035753 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38794
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	"RpL18" likely corresponds to "M(3)65F". (Marygold et al., 2007)
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Likely Minute gene. (Marygold et al., 2007) Deletions removing RpL18 but no other cytoplasmic ribosomal protein-encoding genes show Minute phenotypes. (Marygold et al., 2007) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139834 RefSeq (Proteins) • NP_648091 DDBJ / EMBL / GenBank • AAF50596 AAM29559 AY113554 BI569687 Entrez Gene - A searchable database of RefSeq genes. • 38794 UniProtKB/TrEMBL • Q9VS34
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L18e (IPR000039) Ribosomal protein L18e/L15P (IPR021131) Ribosomal protein L18e, conserved site (IPR021132)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64237 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035753 DroID - A comprehensive database of gene and protein interactions. • FBgn0035753 DRSC - Results from RNAi screens. • FBgn0035753 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035753 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8615-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035753 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38794 InParanoid A subset of ortholog calls from InParanoid. • AAEL008481-PA Aedes aegypti (mosquito) AGAP007580-PB Anopheles gambiae (mosquito) XP_392565.1 Apis mellifera (honey bee) XP_001948546.1 Acyrthosiphon pisum (pea aphid) At3g05590.1 Arabidopsis thaliana (wall cress) 87003 Batrachochytrium dendrobatidis (chytrid fungus) 275280 Branchiostoma floridae (lancelet) 61894 Branchiostoma floridae (lancelet) XP_001897286.1 Brugia malayi (roundworm nematode) BGIBMGA011620-PA Bombyx mori (silk worm) ENSBTAP00000020452 Bos taurus (bovine) CAL0003449 Candida albicans (a form of yeast) CN10002 Caenorhabditis brenneri (small nematode) CBP12125 Caenorhabditis briggsae (nematode) CE16650 Caenorhabditis elegans (worm) ENSCAFP00000005899 Canis familiaris (dog) CAGL0E02013g Candida glabrata (haploid yeast) Chro.40062 Cryptosporidium hominis (obligate parasite) ENSCINP00000024062 Ciona intestinalis (sea squirt) JA18791 Caenorhabditis japonica (nematode) CMB018C Cyanidioschyzon merolae (red alga) cn04293 Cryptococcus neoformans (yeast-like fungus) cgd4_470 Cryptosporidium parvum (protozoan parasite) CPIJ000205 Culex pipens (mosquito) ENSCPOP00000019149 Cavia porcellus (guinea pig) 144684 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000011287 Ciona savignyi (sedentary tunicate) 159560 Capitella spl (polychaete worm) DDB0229960 Dictyostelium discoideum (amoeba) DEHA2F16566g Debaryomyces Hansenii (yeast) 303528 Daphnia pulex (daphnia) ENSDARP00000043172 Danio rerio (zebra fish) ENSECAP00000019435 Equus caballus (horse) XP_649082 Entamoeba histolytica (anaerobic protozoan) XP_654919 Entamoeba histolytica (anaerobic protozoan) XP_656024 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000015306 Gymnopilus aculeatus (mushroom) GL50803_11950 Giardia lamblia (flagellated protozoan) 156470 Hypsipyla robusta (cedar shoot borer) ENSP00000084795 Homo sapiens (human) ISCW021924-PA Ixodes scapularis (deer tick) KLLA0A07227g Kluyveromyces lactis (yeast) 205248 Lottia gigantea (owl limpet) LmjF13.0560 Leishmania major (virus) LmjF36.4510 Leishmania major (virus) 20935 Monocosta brevicollis (choanoflagellate) ENSMODP00000017629 Monodelphis domestica (gray opossum) ENSMMUP00000029169 Macaca mulatta (rhesus monkey) ENSMMUP00000032947 Macaca mulatta (rhesus monkey) ENSMMUP00000033712 Macaca mulatta (rhesus monkey) ENSMUSP00000103365 Mus musculus (house mouse) 236404 Nematostella vectensis (starlet anemone) XP_001607758.1 Nasonia vitripennis (wasp) ENSORLP00000013731 Oryzias latipes (japanese killifish) LOC_Os05g06310.1 Oryza sativa (asian rice) 26333 Ostreococcus tauri (green alga) MAL13P1.209 Plasmodium falciparum (protozoal parasite) PHUM000951-PA Pediculus humanus (human body louse) PP13042 Pristionchus pacificus (nematode) 162579 Physcomitrella patens (moss) ENSPPYP00000011412 Pongo pygmaeus (orangutan) 74564 Phytophthora ramorum (sudden oak death pathogen) 115505 Phytophthora sojae (root rot pathogen) 552462 Populus trichocarpa (black cottonwood) ENSPTRP00000019289 Pan troglodytes (chimpanzee) PVX_082970 Plasmodium vivax (protozoal parasite) ENSRNOP00000028555 Rattus norvegicus (norway rat) 4876869 Sorghum bicolor (sorghum) YNL301C Saccharomyces cerevisiae (budding yeast) YOL120C Saccharomyces cerevisiae (budding yeast) Smp_031570 Schistosoma mansoni (trematode parasite) SPAPB17E12.13 Schizosaccharomyces pombe (fission yeast) XP_001191566.1 Strongylocentrotus purpuratus (purple sea urchin) 52962 Trichoplax adhaerens (metazoa) TA15200 Theileria annulata (apicomplexan parasite) XP_968042.1 Tribolium castaneum (red flour beetle) Tc00.1047053503395.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053504147.20 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506181.50 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010901 Tetraodon nigroviridis (green spotted pufferfish) TP02_0801 Theileria parva (parasitic protozoan) 41319 Thalassiosira pseudonana (marine diatom) ENSTRUP00000039889 Takifugu rubripes (pufferfish Takifugu) 3711.m00085 Tetrahymena thermophila (ciliate protozoa) 88439.m00044 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000006884 Xenopus tropicalis (frog) YALI0B08866g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38794 modMine - Data generated by the modENCODE project. • FBgn0035753 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB13795 NV13677 LH24399 RL18_IXOSC FBgn0237750 FBgn0215168 FBgn0200585 FBgn0184804 FBgn0168716 JGI_V11_303528 FBgn0249124 FBgn0081198 FBgn0162489 FBgn0150819 FBgn0134846 FBgn0122627 FBgn0107243 FBgn0101776 CPIJ000205 BGIBMGA011620 ACYPI006857 GB11029 RL18_ANOGA RL18_AEDAE PHUM042190 GLEAN_03672
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG8615 (Boutros et al., 2004, Goshima et al., 2007, Marygold et al., 2007, Keleman et al., 2009.8.5, Spain et al., 2010, Cammarato et al., 2011) RpL18 (Marygold et al., 2007, Spain et al., 2010) Rp L18 (Alonso and Santaren, 2006) RpL18e (Goshima et al., 2007)
Name Synonym	Ribosomal protein L18 (Ashburner and Marygold, 2004.7.2, Cammarato et al., 2011)
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 5 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Spain et al., 2010, J. Biol. Chem. 285(35): 27457--27467 Drosophila SIN3 isoforms interact with distinct proteins and have unique biological functions. [FBrf0211588] Show all research papers ...