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Gene Dmel\unc-13-4A

General Information
Symbol	Dmel\unc-13-4A	Species	D. melanogaster
Name	unc-13-4A	Annotation symbol	CG32381
Feature type	protein_coding_gene	FlyBase ID	FBgn0035756
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65E10-65E11	Sequence location	3L:7,261,249..7,278,137 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene unc-13-4A is referred to in FlyBase by the symbol Dmel\unc-13-4A (CG32381, FBgn0035756). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. It is reported to be involved in the biological process: neurotransmitter secretion; synaptic vesicle priming. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: C2 calcium-dependent membrane targeting; C2 calcium/lipid-binding domain, CaLB; C2 membrane targeting protein; Mammalian uncoordinated homology 13, domain 2; Mammalian uncoordinated homology 13, subgroup, domain 2; Munc13 homology 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. Gene sequence location is 3L:7261249..7278137.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA10201 HFA10203 HFA10202 BKN22264 HFA11013
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65E10-65E11   Limits computationally determined from genome sequence between P{lacW}Cdc27L7123 and P{EP}larkEP3259&P{lacW}l(3)j1D5j1D5
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65F-65F   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\unc-13-4A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) unc-13-4A-RB FBtr0290001  NM_139839   5113   1371
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein unc-13-4A-PB   FBpp0288440   154.1   1371   6.37     NP_648096   AAF50588
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium-dependent membrane targeting (IPR000008) C2 calcium/lipid-binding domain, CaLB (IPR008973) Munc13 homology 1 (IPR014770) Mammalian uncoordinated homology 13, domain 2 (IPR014772) Mammalian uncoordinated homology 13, subgroup, domain 2 (IPR019558)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567946   AE014296 AAF50588   AI388383   AI946442   BI606325   BI614967   BI617837   BI625019   BI625643   BT011431   CK131218   CO323892   CZ469044   CZ469053   CZ469054   CZ488348   CZ488349   EC246690
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VS41
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035756    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035756 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035756 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr  (310) embryo 16-18hr  (599) embryo 18-20hr  (680) embryo 20-22hr  (591) embryo 22-24hr  (598) larva L1  (526) larva L2  (137) larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP  (144) pupae 3d postWPP  (176) pupae 4d postWPP  (171) adult male 01day  (160) adult male 05day  (198) adult male 30day  (210) adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035756 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr  (310) embryo 16-18hr  (599) embryo 18-20hr  (680) embryo 20-22hr  (591) embryo 22-24hr  (598) larva L1  (526) larva L2  137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP  (144) pupae 3d postWPP  (176) pupae 4d postWPP  (171) adult male 01day  (160) adult male 05day  (198) adult male 30day  (210) adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    5 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    7 embryo 10-12hr    7 embryo 12-14hr    22 embryo 14-16hr    310 embryo 16-18hr    599 embryo 18-20hr    680 embryo 20-22hr    591 embryo 22-24hr    598 larva L1    526 larva L2    137 larva L3 12hr old    37 larva L3 puffstage 1-2    16 larva L3 puffstage 3-6    62 larva L3 puffstage 7-9    63 white prepupae new    54 white prepupae 12hr    51 white prepupae 24hr    92 pupae 2d postWPP    144 pupae 3d postWPP    176 pupae 4d postWPP    171 adult male 01day    160 adult male 05day    198 adult male 30day    210 adult female 01day    73 adult female 05day    20 adult female 30day    23 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035756    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035756 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea no informative data Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_14
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035756 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CT34649;CT34648;CG32381-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 unc-13-4AGD10675 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of unc-13-4A Class Mutagen Stocks Known lesion unc-13-4Ac04173 piggyBac transposase 1 -- unc-13-4Ac04187 piggyBac transposase 1 -- unc-13-4Af05727 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of unc-13-4A Class Mutagen Stocks Known lesion unc-13-4AGD10675 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes unc-13-4AJF03340 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes unc-13-4AKK102198 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6111 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10675} NA P{KK102198} NA P{TRiP.JF03340} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}unc-13-4Ac04173 NA PBac{PB}unc-13-4Ac04187 NA PBac{WH}unc-13-4Af05727 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000) synaptic vesicle priming non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
synaptic vesicle non-traceable author statement (Lloyd et al., 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions unc-13-4A allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64244 DroID - A comprehensive database of gene and protein interactions. • FBgn0035756 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38801
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23863 Dere\GG14984 Dgri\GH15508 Dmoj\GI16784 Dper\GL21182 Dpse\GA16858 Dsec\GM13778 Dsim\GD13077 Dvir\GJ12527 Dwil\GK16673 Dyak\GE20430
Curated drosophilid orthologs	Dpse\GA16858
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002724-PA Aedes aegypti (mosquito) AGAP005816-PA Anopheles gambiae (mosquito) XP_001946668.1 Acyrthosiphon pisum (pea aphid) 88240 Batrachochytrium dendrobatidis (chytrid fungus) 69167 Branchiostoma floridae (lancelet) ENSBTAP00000018748 Bos taurus (bovine) CN05109 Caenorhabditis brenneri (small nematode) CBP31287 Caenorhabditis briggsae (nematode) CE37652 Caenorhabditis elegans (worm) ENSCAFP00000028971 Canis familiaris (dog) ENSCINP00000011505 Ciona intestinalis (sea squirt) JA00934 Caenorhabditis japonica (nematode) CPIJ007008 Culex pipens (mosquito) ENSCPOP00000009372 Cavia porcellus (guinea pig) RP46459 Caenorhabditis remanei (nematode) ENSCSAVP00000017111 Ciona savignyi (sedentary tunicate) 226475 Capitella spl (polychaete worm) 236 Daphnia pulex (daphnia) ENSDARP00000064751 Danio rerio (zebra fish) ENSDARP00000083036 Danio rerio (zebra fish) ENSECAP00000014911 Equus caballus (horse) ENSGACP00000018495 Gymnopilus aculeatus (mushroom) ENSGALP00000003491 Gallus gallus (chicken) 186739 Hypsipyla robusta (cedar shoot borer) ENSP00000324510 Homo sapiens (human) ISCW005596-PA Ixodes scapularis (deer tick) 91451 Lottia gigantea (owl limpet) ENSMODP00000020245 Monodelphis domestica (gray opossum) ENSMMUP00000028213 Macaca mulatta (rhesus monkey) ENSMUSP00000049805 Mus musculus (house mouse) ENSORLP00000006317 Oryzias latipes (japanese killifish) PHUM002855-PA Pediculus humanus (human body louse) PP13718 Pristionchus pacificus (nematode) ENSPPYP00000007865 Pongo pygmaeus (orangutan) ENSPTRP00000012971 Pan troglodytes (chimpanzee) ENSRNOP00000024072 Rattus norvegicus (norway rat) Smp_157090 Schistosoma mansoni (trematode parasite) 60504 Trichoplax adhaerens (metazoa) XP_972990.1 Tribolium castaneum (red flour beetle) ENSTNIP00000002859 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031190 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046644 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12978 LH15723 ISCW005596 FBgn0237745 FBgn0218675 FBgn0199767 FBgn0184799 FBgn0168709 JGI_V11_236 FBgn0076872 FBgn0158775 FBgn0139531 FBgn0122980 FBgn0107238 FBgn0100857 CPIJ007008 BGIBMGA011705 BGIBMGA011704 ACYPI004409 GB17246 AGAP005816 AAEL002724 PHUM188690 GLEAN_02977
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	32033 y1 v1; P{TRiP.JF03340}attP2
Harvard	- PBac{PB}unc-13-4Ac04173 - PBac{PB}unc-13-4Ac04187 - PBac{WH}unc-13-4Af05727
VDRC	v41835 w1118 P{GD10675}v41835
Genomic Clones ( 2 )
	BACR11B04 BACR16I16 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 10 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH64806
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	HL02033 RH44472 RH48288 RH66110 RH72647
Other clones	65488 bs25h08 EK191831 GH19275
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035756 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38801
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: unc-13-4A CG8608 (Verstreken and Bellen, 2000.9.4)
Source for database merge of	Source for merge of: CG14831 CG14832 CG14833 CG8608 (FlyBase Genome Annotators, 2002-2003)
Additional comments	Annotations CG14831, CG14832, CG14833 and CG8608 merged as CG32381 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139839 RefSeq (Proteins) • NP_648096 DDBJ / EMBL / GenBank • AAF50588 AI388383 AI946442 BI625019 CZ469044 CZ469053 CZ469054 CZ488348 CZ488349 Entrez Gene - A searchable database of RefSeq genes. • 38801 UniProtKB/TrEMBL • Q9VS41
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • C2 membrane targeting protein (IPR018029) C2 calcium-dependent membrane targeting (IPR000008) C2 calcium/lipid-binding domain, CaLB (IPR008973) Munc13 homology 1 (IPR014770) Mammalian uncoordinated homology 13, domain 2 (IPR014772) Mammalian uncoordinated homology 13, subgroup, domain 2 (IPR019558)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64244 DroID - A comprehensive database of gene and protein interactions. • FBgn0035756 DRSC - Results from RNAi screens. • FBgn0035756 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035756 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CT34649;CT34648;CG32381-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035756 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38801 InParanoid A subset of ortholog calls from InParanoid. • AAEL002724-PA Aedes aegypti (mosquito) AGAP005816-PA Anopheles gambiae (mosquito) XP_001946668.1 Acyrthosiphon pisum (pea aphid) 88240 Batrachochytrium dendrobatidis (chytrid fungus) 69167 Branchiostoma floridae (lancelet) ENSBTAP00000018748 Bos taurus (bovine) CN05109 Caenorhabditis brenneri (small nematode) CBP31287 Caenorhabditis briggsae (nematode) CE37652 Caenorhabditis elegans (worm) ENSCAFP00000028971 Canis familiaris (dog) ENSCINP00000011505 Ciona intestinalis (sea squirt) JA00934 Caenorhabditis japonica (nematode) CPIJ007008 Culex pipens (mosquito) ENSCPOP00000009372 Cavia porcellus (guinea pig) RP46459 Caenorhabditis remanei (nematode) ENSCSAVP00000017111 Ciona savignyi (sedentary tunicate) 226475 Capitella spl (polychaete worm) 236 Daphnia pulex (daphnia) ENSDARP00000064751 Danio rerio (zebra fish) ENSDARP00000083036 Danio rerio (zebra fish) ENSECAP00000014911 Equus caballus (horse) ENSGACP00000018495 Gymnopilus aculeatus (mushroom) ENSGALP00000003491 Gallus gallus (chicken) 186739 Hypsipyla robusta (cedar shoot borer) ENSP00000324510 Homo sapiens (human) ISCW005596-PA Ixodes scapularis (deer tick) 91451 Lottia gigantea (owl limpet) ENSMODP00000020245 Monodelphis domestica (gray opossum) ENSMMUP00000028213 Macaca mulatta (rhesus monkey) ENSMUSP00000049805 Mus musculus (house mouse) ENSORLP00000006317 Oryzias latipes (japanese killifish) PHUM002855-PA Pediculus humanus (human body louse) PP13718 Pristionchus pacificus (nematode) ENSPPYP00000007865 Pongo pygmaeus (orangutan) ENSPTRP00000012971 Pan troglodytes (chimpanzee) ENSRNOP00000024072 Rattus norvegicus (norway rat) Smp_157090 Schistosoma mansoni (trematode parasite) 60504 Trichoplax adhaerens (metazoa) XP_972990.1 Tribolium castaneum (red flour beetle) ENSTNIP00000002859 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000031190 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000046644 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38801 modMine - Data generated by the modENCODE project. • FBgn0035756 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12978 LH15723 ISCW005596 FBgn0237745 FBgn0218675 FBgn0199767 FBgn0184799 FBgn0168709 JGI_V11_236 FBgn0076872 FBgn0158775 FBgn0139531 FBgn0122980 FBgn0107238 FBgn0100857 CPIJ007008 BGIBMGA011705 BGIBMGA011704 ACYPI004409 GB17246 AGAP005816 AAEL002724 PHUM188690 GLEAN_02977
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG8608 (Whitfield et al., 2002, ) CG14831   CG14832   CG14833 (Boutros et al., 2004, ) CG32381 (Holloway et al., 2008, Bergman et al., 2006, Perkins et al., 2009, Keleman et al., 2009.8.5) dunc-13-4A (Lloyd et al., 2000) unc-13-4A (Holloway et al., 2008)
Name Synonym	unc-13-4A
Secondary FlyBase IDs
	FBgn0035757 FBgn0035758 FBgn0035759 FBgn0052381
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 4 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 1 ) Letter  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...