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Gene Dmel\CG8602

General Information
Symbol	Dmel\CG8602	Species	D. melanogaster
Name		Annotation symbol	CG8602
Feature type	protein_coding_gene	FlyBase ID	FBgn0035763
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65F4-65F4	Sequence location	3L:7,319,373..7,321,958 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8602 (FBgn0035763). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: transmembrane transport. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Major facilitator superfamily; Major facilitator superfamily domain; Major facilitator superfamily domain, general substrate transporter. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval salivary gland, larval trachea, adult testis, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1632481_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG8602. Gene sequence location is 3L:7319373..7321958.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 42 of adulthood day 41 of adulthood day 30 of adulthood day 49 of adulthood day 17 of adulthood day 45 of adulthood day 8 of adulthood day 26 of adulthood day 21 of adulthood day 13 of adulthood day 25 of adulthood day 20 of adulthood day 22 of adulthood day 39 of adulthood day 7 of adulthood day 36 of adulthood day 11 of adulthood day 37 of adulthood day 27 of adulthood day 18 of adulthood day 19 of adulthood day 28 of adulthood day 9 of adulthood day 29 of adulthood adult heart day 40 of adulthood day 16 of adulthood day 24 of adulthood day 15 of adulthood day 33 of adulthood day 43 of adulthood day 47 of adulthood day 38 of adulthood day 32 of adulthood day 48 of adulthood day 23 of adulthood day 35 of adulthood day 12 of adulthood day 10 of adulthood day 31 of adulthood day 34 of adulthood day 44 of adulthood day 14 of adulthood day 46 of adulthood
FB2012_01	Sequence features HFA11009 BKN24843
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65F4-65F4   Limits computationally determined from genome sequence between P{lacW}Cdc27L7123 and P{EP}larkEP3259&P{lacW}l(3)j1D5j1D5
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8602 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8602-RA FBtr0076884  NM_139846   2586   478
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8602-PA   FBpp0076594   53.3   478   6.35     NP_648103   AAF50582
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Major facilitator superfamily (IPR011701) Major facilitator superfamily domain, general substrate transporter (IPR016196) Major facilitator superfamily domain (IPR020846)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390268   AA441568   AA540465   AA540743   AA540822   AA802112   AE014296 AAF50582   AI063868   AI064582   AI512414   AI515086   AI519458   AI519658   AI520038   AI534142   AQ025280   AW943490   AX094225   AX094258   AY069628 AAL39773   BG636394   BG637462   BG638234   BI166409   BI166903   BI169333   BI170046   BI213249   BI215354   BI215597   BI227993   BI228817   BI228938   BI229361   BI229534   BI233061   BI239937   BI240066   BI241259   BI357548   BI361916   BI363893   BI370117   BI372648   BI374483   BI375949   BI483389   BI486366   BI563576   BI568076   BI576126   BI609710   BI612552   BI629217   CA805012   CA806493   CK657014   CO156663   CO178877   CO272379   CO280163   CO282079   CO282957   CO284426   CO294886   CO296956   CO307585   CO324303   CO340792   DN154117   EC062588   EC064404   EC073278   EC074775   EC075557   EC080627   EC213351   EC232334   EC241710   EC245502   EC249412   EC253398   EC265815   EV579915
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VS47
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035763    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035763 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035763 expression level Developmental Stage   Expression Level embryo 00-02hr    4879 embryo 02-04hr    7519 embryo 04-06hr    6124 embryo 06-08hr    8414 embryo 08-10hr    9088 embryo 10-12hr    8967 embryo 12-14hr    7019 embryo 14-16hr    4746 embryo 16-18hr    3907 embryo 18-20hr    3041 embryo 20-22hr    2636 embryo 22-24hr    2991 larva L1    1136 larva L2    1237 larva L3 12hr old    1474 larva L3 puffstage 1-2    2054 larva L3 puffstage 3-6    3330 larva L3 puffstage 7-9    4674 white prepupae new    5247 white prepupae 12hr    6065 white prepupae 24hr    4735 pupae 2d postWPP    4123 pupae 3d postWPP    3824 pupae 4d postWPP    1763 adult male 01day    3125 adult male 05day    2371 adult male 30day    1814 adult female 01day    4321 adult female 05day    4771 adult female 30day    4851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4879) embryo 02-04hr  (7519) embryo 04-06hr  (6124) embryo 06-08hr  (8414) embryo 08-10hr  (9088) embryo 10-12hr  (8967) embryo 12-14hr  (7019) embryo 14-16hr  (4746) embryo 16-18hr  (3907) embryo 18-20hr  (3041) embryo 20-22hr  (2636) embryo 22-24hr  (2991) larva L1  (1136) larva L2  (1237) larva L3 12hr old  (1474) larva L3 puffstage 1-2  (2054) larva L3 puffstage 3-6  (3330) larva L3 puffstage 7-9  (4674) white prepupae new  (5247) white prepupae 12hr  (6065) white prepupae 24hr  (4735) pupae 2d postWPP  (4123) pupae 3d postWPP  (3824) pupae 4d postWPP  (1763) adult male 01day  (3125) adult male 05day  (2371) adult male 30day  (1814) adult female 01day  (4321) adult female 05day  (4771) adult female 30day  (4851) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4879) embryo 02-04hr  (7519) embryo 04-06hr  (6124) embryo 06-08hr  (8414) embryo 08-10hr  (9088) embryo 10-12hr  (8967) embryo 12-14hr  (7019) embryo 14-16hr  (4746) embryo 16-18hr  (3907) embryo 18-20hr  (3041) embryo 20-22hr  (2636) embryo 22-24hr  (2991) larva L1    1136 larva L2    1237 larva L3 12hr old  1474 larva L3 puffstage 1-2  (2054) larva L3 puffstage 3-6  (3330) larva L3 puffstage 7-9  (4674) white prepupae new  (5247) white prepupae 12hr  (6065) white prepupae 24hr  (4735) pupae 2d postWPP  (4123) pupae 3d postWPP  (3824) pupae 4d postWPP  (1763) adult male 01day  (3125) adult male 05day  (2371) adult male 30day  (1814) adult female 01day  (4321) adult female 05day  (4771) adult female 30day  (4851) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4879 embryo 02-04hr    7519 embryo 04-06hr    6124 embryo 06-08hr    8414 embryo 08-10hr    9088 embryo 10-12hr    8967 embryo 12-14hr    7019 embryo 14-16hr    4746 embryo 16-18hr    3907 embryo 18-20hr    3041 embryo 20-22hr    2636 embryo 22-24hr    2991 larva L1    1136 larva L2    1237 larva L3 12hr old    1474 larva L3 puffstage 1-2    2054 larva L3 puffstage 3-6    3330 larva L3 puffstage 7-9    4674 white prepupae new    5247 white prepupae 12hr    6065 white prepupae 24hr    4735 pupae 2d postWPP    4123 pupae 3d postWPP    3824 pupae 4d postWPP    1763 adult male 01day    3125 adult male 05day    2371 adult male 30day    1814 adult female 01day    4321 adult female 05day    4771 adult female 30day    4851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4879 embryo 02-04hr    7519 embryo 04-06hr    6124 embryo 06-08hr    8414 embryo 08-10hr    9088 embryo 10-12hr    8967 embryo 12-14hr    7019 embryo 14-16hr    4746 embryo 16-18hr    3907 embryo 18-20hr    3041 embryo 20-22hr    2636 embryo 22-24hr    2991 larva L1    1136 larva L2    1237 larva L3 12hr old    1474 larva L3 puffstage 1-2    2054 larva L3 puffstage 3-6    3330 larva L3 puffstage 7-9    4674 white prepupae new    5247 white prepupae 12hr    6065 white prepupae 24hr    4735 pupae 2d postWPP    4123 pupae 3d postWPP    3824 pupae 4d postWPP    1763 adult male 01day    3125 adult male 05day    2371 adult male 30day    1814 adult female 01day    4321 adult female 05day    4771 adult female 30day    4851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035763 expression level Developmental Stage   Expression Level embryo 00-02hr    4879 embryo 02-04hr    7519 embryo 04-06hr    6124 embryo 06-08hr    8414 embryo 08-10hr    9088 embryo 10-12hr    8967 embryo 12-14hr    7019 embryo 14-16hr    4746 embryo 16-18hr    3907 embryo 18-20hr    3041 embryo 20-22hr    2636 embryo 22-24hr    2991 larva L1    1136 larva L2    1237 larva L3 12hr old    1474 larva L3 puffstage 1-2    2054 larva L3 puffstage 3-6    3330 larva L3 puffstage 7-9    4674 white prepupae new    5247 white prepupae 12hr    6065 white prepupae 24hr    4735 pupae 2d postWPP    4123 pupae 3d postWPP    3824 pupae 4d postWPP    1763 adult male 01day    3125 adult male 05day    2371 adult male 30day    1814 adult female 01day    4321 adult female 05day    4771 adult female 30day    4851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4879) embryo 02-04hr  (7519) embryo 04-06hr  (6124) embryo 06-08hr  (8414) embryo 08-10hr  (9088) embryo 10-12hr  (8967) embryo 12-14hr  (7019) embryo 14-16hr  (4746) embryo 16-18hr  (3907) embryo 18-20hr  (3041) embryo 20-22hr  (2636) embryo 22-24hr  (2991) larva L1  (1136) larva L2  (1237) larva L3 12hr old  (1474) larva L3 puffstage 1-2  (2054) larva L3 puffstage 3-6  (3330) larva L3 puffstage 7-9  (4674) white prepupae new  (5247) white prepupae 12hr  (6065) white prepupae 24hr  (4735) pupae 2d postWPP  (4123) pupae 3d postWPP  (3824) pupae 4d postWPP  (1763) adult male 01day  (3125) adult male 05day  (2371) adult male 30day  (1814) adult female 01day  (4321) adult female 05day  (4771) adult female 30day  (4851) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4879) embryo 02-04hr  (7519) embryo 04-06hr  (6124) embryo 06-08hr  (8414) embryo 08-10hr  (9088) embryo 10-12hr  (8967) embryo 12-14hr  (7019) embryo 14-16hr  (4746) embryo 16-18hr  (3907) embryo 18-20hr  (3041) embryo 20-22hr  (2636) embryo 22-24hr  (2991) larva L1    1136 larva L2    1237 larva L3 12hr old  1474 larva L3 puffstage 1-2  2054 larva L3 puffstage 3-6  (3330) larva L3 puffstage 7-9  (4674) white prepupae new  (5247) white prepupae 12hr  (6065) white prepupae 24hr  (4735) pupae 2d postWPP  (4123) pupae 3d postWPP  (3824) pupae 4d postWPP  1763 adult male 01day  (3125) adult male 05day  2371 adult male 30day  1814 adult female 01day  (4321) adult female 05day  (4771) adult female 30day  (4851) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4879 embryo 02-04hr    7519 embryo 04-06hr    6124 embryo 06-08hr    8414 embryo 08-10hr    9088 embryo 10-12hr    8967 embryo 12-14hr    7019 embryo 14-16hr    4746 embryo 16-18hr    3907 embryo 18-20hr    3041 embryo 20-22hr    2636 embryo 22-24hr    2991 larva L1    1136 larva L2    1237 larva L3 12hr old    1474 larva L3 puffstage 1-2    2054 larva L3 puffstage 3-6    3330 larva L3 puffstage 7-9    4674 white prepupae new    5247 white prepupae 12hr    6065 white prepupae 24hr    4735 pupae 2d postWPP    4123 pupae 3d postWPP    3824 pupae 4d postWPP    1763 adult male 01day    3125 adult male 05day    2371 adult male 30day    1814 adult female 01day    4321 adult female 05day    4771 adult female 30day    4851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4879 embryo 02-04hr    7519 embryo 04-06hr    6124 embryo 06-08hr    8414 embryo 08-10hr    9088 embryo 10-12hr    8967 embryo 12-14hr    7019 embryo 14-16hr    4746 embryo 16-18hr    3907 embryo 18-20hr    3041 embryo 20-22hr    2636 embryo 22-24hr    2991 larva L1    1136 larva L2    1237 larva L3 12hr old    1474 larva L3 puffstage 1-2    2054 larva L3 puffstage 3-6    3330 larva L3 puffstage 7-9    4674 white prepupae new    5247 white prepupae 12hr    6065 white prepupae 24hr    4735 pupae 2d postWPP    4123 pupae 3d postWPP    3824 pupae 4d postWPP    1763 adult male 01day    3125 adult male 05day    2371 adult male 30day    1814 adult female 01day    4321 adult female 05day    4771 adult female 30day    4851 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035763    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035763 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult female reproductive system, adult male accessory gland, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult midgut, larval salivary gland, larval trachea, adult testis, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035763 expression level Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut    904.7 Larval Hindgut    674.8 Larval Malpighian Tubules    1619.1 Larval Fat Body    639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head    806.4 Adult Eye    934.3 Adult Brain    545.5 Adult Thoracic-Abdominal Ganglion    649.3 Adult Crop    817.5 Adult Midgut    344.3 Adult Hindgut    702.5 Adult Malpighian Tubules    1105.5 Adult Fat Body    1164.3 Adult Salivary Gland    1065.8 Adult Heart    2391.675 Adult VirginFemale Spermatheca    1895.5 Adult InseminatedFemale Spermatheca    1610.7 Adult Ovary    766.7 Adult Testis    198.1 Adult Male Accessory Gland    973.6 Adult Carcass    782.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut  (904.7) Larval Hindgut  (674.8) Larval Malpighian Tubules  (1619.1) Larval Fat Body  (639) Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head  (806.4) Adult Eye  (934.3) Adult Brain  (545.5) Adult Thoracic-Abdominal Ganglion  (649.3) Adult Crop  (817.5) Adult Midgut    344.3 Adult Hindgut  (702.5) Adult Malpighian Tubules  (1105.5) Adult Fat Body  (1164.3) Adult Salivary Gland  (1065.8) Adult Heart  (2391.675) Adult VirginFemale Spermatheca  (1895.5) Adult InseminatedFemale Spermatheca  (1610.7) Adult Ovary  (766.7) Adult Testis    198.1 Adult Male Accessory Gland  (973.6) Adult Carcass  (782.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut    904.7 Larval Hindgut    674.8 Larval Malpighian Tubules  (1619.1) Larval Fat Body    639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head    806.4 Adult Eye    934.3 Adult Brain    545.5 Adult Thoracic-Abdominal Ganglion    649.3 Adult Crop    817.5 Adult Midgut    344.3 Adult Hindgut    702.5 Adult Malpighian Tubules  (1105.5) Adult Fat Body  (1164.3) Adult Salivary Gland  1065.8 Adult Heart  (2391.675) Adult VirginFemale Spermatheca  (1895.5) Adult InseminatedFemale Spermatheca  (1610.7) Adult Ovary    766.7 Adult Testis    198.1 Adult Male Accessory Gland    973.6 Adult Carcass    782.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut    904.7 Larval Hindgut    674.8 Larval Malpighian Tubules    1619.1 Larval Fat Body    639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head    806.4 Adult Eye    934.3 Adult Brain    545.5 Adult Thoracic-Abdominal Ganglion    649.3 Adult Crop    817.5 Adult Midgut    344.3 Adult Hindgut    702.5 Adult Malpighian Tubules    1105.5 Adult Fat Body    1164.3 Adult Salivary Gland    1065.8 Adult Heart    2391.675 Adult VirginFemale Spermatheca    1895.5 Adult InseminatedFemale Spermatheca    1610.7 Adult Ovary    766.7 Adult Testis    198.1 Adult Male Accessory Gland    973.6 Adult Carcass    782.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035763 expression level Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut    904.7 Larval Hindgut    674.8 Larval Malpighian Tubules    1619.1 Larval Fat Body    639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head    806.4 Adult Eye    934.3 Adult Brain    545.5 Adult Thoracic-Abdominal Ganglion    649.3 Adult Crop    817.5 Adult Midgut    344.3 Adult Hindgut    702.5 Adult Malpighian Tubules    1105.5 Adult Fat Body    1164.3 Adult Salivary Gland    1065.8 Adult Heart    2391.675 Adult VirginFemale Spermatheca    1895.5 Adult InseminatedFemale Spermatheca    1610.7 Adult Ovary    766.7 Adult Testis    198.1 Adult Male Accessory Gland    973.6 Adult Carcass    782.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut  (904.7) Larval Hindgut  674.8 Larval Malpighian Tubules  (1619.1) Larval Fat Body  639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head  806.4 Adult Eye  (934.3) Adult Brain  545.5 Adult Thoracic-Abdominal Ganglion  649.3 Adult Crop  (817.5) Adult Midgut    344.3 Adult Hindgut  702.5 Adult Malpighian Tubules  (1105.5) Adult Fat Body  (1164.3) Adult Salivary Gland  (1065.8) Adult Heart  (2391.675) Adult VirginFemale Spermatheca  (1895.5) Adult InseminatedFemale Spermatheca  (1610.7) Adult Ovary  766.7 Adult Testis    198.1 Adult Male Accessory Gland  (973.6) Adult Carcass  782.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut    904.7 Larval Hindgut    674.8 Larval Malpighian Tubules  1619.1 Larval Fat Body    639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head    806.4 Adult Eye    934.3 Adult Brain    545.5 Adult Thoracic-Abdominal Ganglion    649.3 Adult Crop    817.5 Adult Midgut    344.3 Adult Hindgut    702.5 Adult Malpighian Tubules  1105.5 Adult Fat Body  1164.3 Adult Salivary Gland  1065.8 Adult Heart  (2391.675) Adult VirginFemale Spermatheca  (1895.5) Adult InseminatedFemale Spermatheca  1610.7 Adult Ovary    766.7 Adult Testis    198.1 Adult Male Accessory Gland    973.6 Adult Carcass    782.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    270.075 Larval Midgut    904.7 Larval Hindgut    674.8 Larval Malpighian Tubules    1619.1 Larval Fat Body    639 Larval Salivary Gland    478.6 Larval Trachea    441.7 Larval Carcass    455.175 Adult Head    806.4 Adult Eye    934.3 Adult Brain    545.5 Adult Thoracic-Abdominal Ganglion    649.3 Adult Crop    817.5 Adult Midgut    344.3 Adult Hindgut    702.5 Adult Malpighian Tubules    1105.5 Adult Fat Body    1164.3 Adult Salivary Gland    1065.8 Adult Heart    2391.675 Adult VirginFemale Spermatheca    1895.5 Adult InseminatedFemale Spermatheca    1610.7 Adult Ovary    766.7 Adult Testis    198.1 Adult Male Accessory Gland    973.6 Adult Carcass    782.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    806.4   NA  Eye    934.3   NA  Brain    545.5   270.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    649.3   NA  Crop    817.5   904.7  Midgut    344.3   674.8  Hindgut    702.5   1619.1  Malpighian Tubules    1105.5   639  Fat Body    1164.3   478.6  Salivary Gland    1065.8   NA  Heart    2391.675   441.7  Trachea    NA   NA  VirginFemale Spermatheca    1895.5   NA  InseminatedFemale Spermatheca    1610.7   NA  Ovary    766.7   NA  Testis    198.1   NA  Male Accessory Gland    973.6   455.175  Carcass    782.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035763 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8602-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG8602 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG8602 Class Mutagen Stocks Known lesion CG8602d09937 1 -- CG8602EP3102 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8602 Class Mutagen Stocks Known lesion CG8602KK103883 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG8602GD2345 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2345} NA P{KK103883} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG8602EP3102 NA P{XP}CG8602d09937 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
transmembrane transport inferred from electronic annotation with InterPro:IPR011701 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from electronic annotation with InterPro:IPR011701 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8602 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035763 DroID - A comprehensive database of gene and protein interactions. • FBgn0035763
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23860 Dere\GG14980 Dgri\GH15505 Dmoj\GI16781 Dper\GL21156 Dpse\GA21198 Dsec\GM13776 Dsim\GD13074 Dvir\GJ12524 Dyak\GE20427
Curated drosophilid orthologs	Dpse\GA21198
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006002-PA Aedes aegypti (mosquito) AGAP009523-PA Anopheles gambiae (mosquito) XP_392174.1 Apis mellifera (honey bee) 23019 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA003198-PA Bombyx mori (silk worm) ENSBTAP00000052101 Bos taurus (bovine) CMK236C Cyanidioschyzon merolae (red alga) cn09043 Cryptococcus neoformans (yeast-like fungus) CPIJ002440 Culex pipens (mosquito) DDB0238061 Dictyostelium discoideum (amoeba) 59685 Daphnia pulex (daphnia) LmjF28.0150 Leishmania major (virus) ENSMODP00000014298 Monodelphis domestica (gray opossum) ENSOANP00000014307 Ornithorynchus anatinus (platypus) XP_786299.2 Strongylocentrotus purpuratus (purple sea urchin) 30594 Trichoplax adhaerens (metazoa) XP_972526.1 Tribolium castaneum (red flour beetle) Tc00.1047053506779.90 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511153.110 Trypanosoma cruzi (parasitic trypanosome) 91566.m00126 Trichomonas vaginalis (parasitic flagellated protozoan) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10590 LH25167 ISCW006150 FBgn0237742 FBgn0235735 FBgn0226425 FBgn0219523 FBgn0203474 FBgn0199764 FBgn0194688 FBgn0184796 FBgn0173401 FBgn0168707 JGI_V11_59685 FBgn0081186 FBgn0071521 FBgn0158750 FBgn0156972 FBgn0140843 FBgn0139528 FBgn0031636 FBgn0122977 FBgn0120701 FBgn0117150 FBgn0107234 FBgn0100854 FBgn0092517 CPIJ002440 BGIBMGA003198 ACYPI000279 GB14084 AGAP009523 AAEL006002 PB23931 PHUM509520 GLEAN_14393
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	17262 w1118; P{EP}CG8602EP3102
Harvard	- P{XP}CG8602d09937
VDRC	v101575 P{KK103883}VIE-260B
Genomic Clones ( 1 )
	BACR11B04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 78 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD39967
Other clones	DPiM_LD39967
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03973 GH05044 GM03873 LD08930 LD16546 LD19962 LD20539 LD39063 LD39320 LD44286 LD46769 LP22942 RE06527 RE07149 RE10473 RE11386 RE18614 RE21734 RE22151 RE25390 RE26463 RE26603 RE27128 RE27336 RE29337 RE36562 RE36713 RE38286 RE44063 RE46329 RE48869 RE56524 RE59660 RE62084 RE63857 RE66278 RE69778 RH14530 RH32629 RH34234 RH39430 RH41463 RH58052 SD06660 SD14092 SD15468
Other clones	8227 39821 45662 55618 65894 78403 82458 97535 148670 214541.59 528097 CK01.45A.D11 CK01.73B.D8 Dmel_dig_005497_0689_2709 EK057834 EK106942 EK153112 EK159501 EK161845 EK166028 EK182355 EK193160 EK207915 EK215516 EK255026 EN08527 EP11350 ESG013c.E21_F03 ESG0116a.B21_G06 LD20643
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035763 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38808
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG8602 anon-WO0118547.349 anon-WO0118547.382 (FlyBase, 1996-)
Additional comments	The CG8602 gene may be derived from the CG12194 gene by retroposition. (Betran et al., 2002) Source for merge of CG8602 anon-WO0118547.349 anon-WO0118547.382 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Area matching Drosophila EST AA540743. This EST forms a 1129bp contig with ESTs AI064582, AI519458 and AA568024. (Davies, 2001.3.15) Area matching Drosophila EST AA441568. (Davies, 2001.3.15)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139846 RefSeq (Proteins) • NP_648103 DDBJ / EMBL / GenBank • AA441568 AA540743 AAF50582 AAL39773 AI520038 AQ025280 AW943490 AX094225 AX094258 AY069628 Entrez Gene - A searchable database of RefSeq genes. • 38808 UniProtKB/TrEMBL • Q9VS47
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Major facilitator superfamily (IPR011701) Major facilitator superfamily domain, general substrate transporter (IPR016196) Major facilitator superfamily domain (IPR020846)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035763 DroID - A comprehensive database of gene and protein interactions. • FBgn0035763 DRSC - Results from RNAi screens. • FBgn0035763 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035763 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8602-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035763 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38808 InParanoid A subset of ortholog calls from InParanoid. • AAEL006002-PA Aedes aegypti (mosquito) AGAP009523-PA Anopheles gambiae (mosquito) XP_392174.1 Apis mellifera (honey bee) 23019 Batrachochytrium dendrobatidis (chytrid fungus) BGIBMGA003198-PA Bombyx mori (silk worm) ENSBTAP00000052101 Bos taurus (bovine) CMK236C Cyanidioschyzon merolae (red alga) cn09043 Cryptococcus neoformans (yeast-like fungus) CPIJ002440 Culex pipens (mosquito) DDB0238061 Dictyostelium discoideum (amoeba) 59685 Daphnia pulex (daphnia) LmjF28.0150 Leishmania major (virus) ENSMODP00000014298 Monodelphis domestica (gray opossum) ENSOANP00000014307 Ornithorynchus anatinus (platypus) XP_786299.2 Strongylocentrotus purpuratus (purple sea urchin) 30594 Trichoplax adhaerens (metazoa) XP_972526.1 Tribolium castaneum (red flour beetle) Tc00.1047053506779.90 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511153.110 Trypanosoma cruzi (parasitic trypanosome) 91566.m00126 Trichomonas vaginalis (parasitic flagellated protozoan) modMine - Data generated by the modENCODE project. • FBgn0035763 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10590 LH25167 ISCW006150 FBgn0237742 FBgn0235735 FBgn0226425 FBgn0219523 FBgn0203474 FBgn0199764 FBgn0194688 FBgn0184796 FBgn0173401 FBgn0168707 JGI_V11_59685 FBgn0081186 FBgn0071521 FBgn0158750 FBgn0156972 FBgn0140843 FBgn0139528 FBgn0031636 FBgn0122977 FBgn0120701 FBgn0117150 FBgn0107234 FBgn0100854 FBgn0092517 CPIJ002440 BGIBMGA003198 ACYPI000279 GB14084 AGAP009523 AAEL006002 PB23931 PHUM509520 GLEAN_14393
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	anon-WO0118547.349   anon-WO0118547.382   CG8602 (Keleman et al., 2009.8.5, Cammarato et al., 2011)
Name Synonym
Secondary FlyBase IDs
	FBgn0062051 FBgn0062076
References ( 16 )
Research paper	Chen et al., 2008, Genome Res. 18(1): 123--136 Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. [FBrf0202125] Betran et al., 2002, Genome Res. 12(12): 1854--1859 Retroposed new genes out of the X in Drosophila. [FBrf0155820]
Supplementary material	Cammarato et al., 2011, PLoS ONE 6(4): Table S1. Proteins & Peptides. [FBrf0214682] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Patent	Davies et al., 2001, World Patent 0118547: Essential genes and assays relating thereto. [FBrf0199103]
DNA/RNA sequence record	Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094225 Sequence 349 from Patent WO0118547. [FBrf0150056] Davies, 2001.3.15, GenBank/EMBL/DDBJ: AX094258 Sequence 382 from Patent WO0118547. [FBrf0150093]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ketchum, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126677]