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Gene Dmel\Sh3β

General Information
Symbol	Dmel\Sh3β	Species	D. melanogaster
Name	Sh3β	Annotation symbol	CG8582
Feature type	protein_coding_gene	FlyBase ID	FBgn0035772
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Sh3beta
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65F7-65F7	Sequence location	3L:7,357,684..7,362,360 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sh3β is referred to in FlyBase by the symbol Dmel\Sh3β (CG8582, FBgn0035772). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: SH3-binding, glutamic acid-rich protein; Thioredoxin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed during late larval stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult Malpighian tubules, adult fat body, adult salivary gland, adult testis, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625453_a_at completely aligns to an exonic region of only a subset of 3 of the 5 FlyBase-annotated transcript isoforms of Sh3beta. Gene sequence location is 3L:7357684..7362360.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles Sh3beta[DOr]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65F7-65F7   Limits computationally determined from genome sequence between P{EP}larkEP3259&P{lacW}l(3)j1D5j1D5 and P{PZ}l(3)0721708223&P{EP}Rac2EP3118
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sh3β for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sh3β-RA FBtr0076872  NM_168210   1419   158 Sh3β-RB FBtr0076873  NM_139855   1515   158 Sh3β-RC FBtr0302546  NM_001202126   1272   146 Sh3β-RD FBtr0302547  NM_001202127   1253   216 Sh3β-RE FBtr0302548  NM_001202128   2338   485
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sh3β-PA   FBpp0076582   17.5   158   4.14     NP_729248   AAN12061 Sh3β-PB   FBpp0076583   17.5   158   4.14     NP_648112   AAF50570 Sh3β-PC   FBpp0291702   16.2   146   4.12     NP_001189055   ADV37492 Sh3β-PD   FBpp0291703   23.6   216   4.10     NP_001189056   ADV37493 Sh3β-PE   FBpp0291704   54.2   485   3.81     NP_001189057   ADV37494
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SH3-binding, glutamic acid-rich protein (IPR006993) Thioredoxin-like fold (IPR012336)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391374   AA438597   AA695942   AE014296 AAF50570   AE014296 AAN12061   AE014296 ADV37492   AE014296 ADV37493   AE014296 ADV37494   AI404072   AJ272505 CAB76915   AW942252   AY061162 AAL28710   BE977134   BF501985   BG633648   BG636468   BI216463   BI238491   BI239261   BI368035   BI482169   BI578260   BI610433   BP546581   CA804060   CA806587   CA806780   CA806944   CA807693   CK662006   CO152998   CO153002   CO178866   CO186568   CO189082   CO269189   CO278217   CO278921   CO288535   CO291087   CO291631   CO293278   CO293681   CO318240   CO321892   CO322108   CO326901   CO333838   CO335975   CO338178   CO344501   EC058620   EC061979   EC071185   EC072995   EC074477   EC076888   EC081972   EC084180   EC085920   EC088097   EC090790   EC203272   EC206849   EC207282   EC211670   EC224314   EC235475   EC244556   EC245232   EC247145   EC250104   EC251877   EC262523   EC264484   EC265403   EV577783
UniProtKB/Swiss-Prot	Q9NFP5
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval fat body, larval salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult Malpighian tubules, adult fat body, adult salivary gland, adult testis, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1339.35 Larval Midgut    2488.1 Larval Hindgut    1669.8 Larval Malpighian Tubules    2901.3 Larval Fat Body    1154.7 Larval Salivary Gland    1679.8 Larval Trachea    1343.825 Larval Carcass    735.125 Adult Head    464.2 Adult Eye    1053.85 Adult Brain    584.2 Adult Thoracic-Abdominal Ganglion    630 Adult Crop    536.9 Adult Midgut    1349.5 Adult Hindgut    527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart    608.575 Adult VirginFemale Spermatheca    633.6 Adult InseminatedFemale Spermatheca    775.5 Adult Ovary    883.6 Adult Testis    379.7 Adult Male Accessory Gland    1343.9 Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1339.35) Larval Midgut  (2488.1) Larval Hindgut  (1669.8) Larval Malpighian Tubules  (2901.3) Larval Fat Body  (1154.7) Larval Salivary Gland  (1679.8) Larval Trachea  (1343.825) Larval Carcass  (735.125) Adult Head    464.2 Adult Eye  (1053.85) Adult Brain  (584.2) Adult Thoracic-Abdominal Ganglion  (630) Adult Crop  536.9 Adult Midgut  (1349.5) Adult Hindgut  527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart  (608.575) Adult VirginFemale Spermatheca  (633.6) Adult InseminatedFemale Spermatheca  (775.5) Adult Ovary  (883.6) Adult Testis    379.7 Adult Male Accessory Gland  (1343.9) Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1339.35) Larval Midgut  (2488.1) Larval Hindgut  (1669.8) Larval Malpighian Tubules  (2901.3) Larval Fat Body  (1154.7) Larval Salivary Gland  (1679.8) Larval Trachea  (1343.825) Larval Carcass    735.125 Adult Head    464.2 Adult Eye  1053.85 Adult Brain    584.2 Adult Thoracic-Abdominal Ganglion    630 Adult Crop    536.9 Adult Midgut  (1349.5) Adult Hindgut    527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart    608.575 Adult VirginFemale Spermatheca    633.6 Adult InseminatedFemale Spermatheca    775.5 Adult Ovary    883.6 Adult Testis    379.7 Adult Male Accessory Gland  (1343.9) Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1339.35 Larval Midgut    2488.1 Larval Hindgut    1669.8 Larval Malpighian Tubules    2901.3 Larval Fat Body    1154.7 Larval Salivary Gland    1679.8 Larval Trachea    1343.825 Larval Carcass    735.125 Adult Head    464.2 Adult Eye    1053.85 Adult Brain    584.2 Adult Thoracic-Abdominal Ganglion    630 Adult Crop    536.9 Adult Midgut    1349.5 Adult Hindgut    527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart    608.575 Adult VirginFemale Spermatheca    633.6 Adult InseminatedFemale Spermatheca    775.5 Adult Ovary    883.6 Adult Testis    379.7 Adult Male Accessory Gland    1343.9 Adult Carcass    334.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1339.35 Larval Midgut    2488.1 Larval Hindgut    1669.8 Larval Malpighian Tubules    2901.3 Larval Fat Body    1154.7 Larval Salivary Gland    1679.8 Larval Trachea    1343.825 Larval Carcass    735.125 Adult Head    464.2 Adult Eye    1053.85 Adult Brain    584.2 Adult Thoracic-Abdominal Ganglion    630 Adult Crop    536.9 Adult Midgut    1349.5 Adult Hindgut    527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart    608.575 Adult VirginFemale Spermatheca    633.6 Adult InseminatedFemale Spermatheca    775.5 Adult Ovary    883.6 Adult Testis    379.7 Adult Male Accessory Gland    1343.9 Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1339.35) Larval Midgut  (2488.1) Larval Hindgut  (1669.8) Larval Malpighian Tubules  (2901.3) Larval Fat Body  (1154.7) Larval Salivary Gland  (1679.8) Larval Trachea  (1343.825) Larval Carcass  735.125 Adult Head    464.2 Adult Eye  (1053.85) Adult Brain  584.2 Adult Thoracic-Abdominal Ganglion  630 Adult Crop  536.9 Adult Midgut  (1349.5) Adult Hindgut  527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart  608.575 Adult VirginFemale Spermatheca  633.6 Adult InseminatedFemale Spermatheca  775.5 Adult Ovary  (883.6) Adult Testis    379.7 Adult Male Accessory Gland  (1343.9) Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1339.35 Larval Midgut  (2488.1) Larval Hindgut  1669.8 Larval Malpighian Tubules  (2901.3) Larval Fat Body  1154.7 Larval Salivary Gland  1679.8 Larval Trachea  1343.825 Larval Carcass    735.125 Adult Head    464.2 Adult Eye  1053.85 Adult Brain    584.2 Adult Thoracic-Abdominal Ganglion    630 Adult Crop    536.9 Adult Midgut  1349.5 Adult Hindgut    527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart    608.575 Adult VirginFemale Spermatheca    633.6 Adult InseminatedFemale Spermatheca    775.5 Adult Ovary    883.6 Adult Testis    379.7 Adult Male Accessory Gland  1343.9 Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1339.35 Larval Midgut    2488.1 Larval Hindgut    1669.8 Larval Malpighian Tubules    2901.3 Larval Fat Body    1154.7 Larval Salivary Gland    1679.8 Larval Trachea    1343.825 Larval Carcass    735.125 Adult Head    464.2 Adult Eye    1053.85 Adult Brain    584.2 Adult Thoracic-Abdominal Ganglion    630 Adult Crop    536.9 Adult Midgut    1349.5 Adult Hindgut    527 Adult Malpighian Tubules    324.9 Adult Fat Body    455.9 Adult Salivary Gland    419.3 Adult Heart    608.575 Adult VirginFemale Spermatheca    633.6 Adult InseminatedFemale Spermatheca    775.5 Adult Ovary    883.6 Adult Testis    379.7 Adult Male Accessory Gland    1343.9 Adult Carcass    334.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    464.2   NA  Eye    1053.85   NA  Brain    584.2   1339.35  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    630   NA  Crop    536.9   2488.1  Midgut    1349.5   1669.8  Hindgut    527   2901.3  Malpighian Tubules    324.9   1154.7  Fat Body    455.9   1679.8  Salivary Gland    419.3   NA  Heart    608.575   1343.825  Trachea    NA   NA  VirginFemale Spermatheca    633.6   NA  InseminatedFemale Spermatheca    775.5   NA  Ovary    883.6   NA  Testis    379.7   NA  Male Accessory Gland    1343.9   735.125  Carcass    334.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    98 central nervous system, pupae P8    52 head, virgin 1-day female    28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    89 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    55 fat body, pupae P8    66 carcass, larvae L3 wandering    344 carcass, 1-day adult    41 carcass, 4-day adult    33 carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (55) central nervous system, larvae L3  (98) central nervous system, pupae P8  (52) head, virgin 1-day female  (28) head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female  (28) head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male  (28) head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae  (89) digestive system, larvae L3 wandering  (196) digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae  (55) fat body, pupae P8  (66) carcass, larvae L3 wandering  (344) carcass, 1-day adult  (41) carcass, 4-day adult  (33) carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    98 central nervous system, pupae P8    52 head, virgin 1-day female    28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    89 digestive system, larvae L3 wandering  (196) digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    55 fat body, pupae P8    66 carcass, larvae L3 wandering  (344) carcass, 1-day adult    41 carcass, 4-day adult    33 carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    98 central nervous system, pupae P8    52 head, virgin 1-day female    28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    89 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    55 fat body, pupae P8    66 carcass, larvae L3 wandering    344 carcass, 1-day adult    41 carcass, 4-day adult    33 carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    98 central nervous system, pupae P8    52 head, virgin 1-day female    28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    89 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    55 fat body, pupae P8    66 carcass, larvae L3 wandering    344 carcass, 1-day adult    41 carcass, 4-day adult    33 carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (55) central nervous system, larvae L3  (98) central nervous system, pupae P8  (52) head, virgin 1-day female  28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female  28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male  28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae  (89) digestive system, larvae L3 wandering  (196) digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae  (55) fat body, pupae P8  (66) carcass, larvae L3 wandering  (344) carcass, 1-day adult  (41) carcass, 4-day adult  (33) carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    98 central nervous system, pupae P8    52 head, virgin 1-day female    28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    89 digestive system, larvae L3 wandering  (196) digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    55 fat body, pupae P8    66 carcass, larvae L3 wandering  (344) carcass, 1-day adult    41 carcass, 4-day adult    33 carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    55 central nervous system, larvae L3    98 central nervous system, pupae P8    52 head, virgin 1-day female    28 head, virgin 4-day female    21 head, virgin 20-day female    10 head, mated 1-day female    28 head, mated 4-day female    18 head, mated 20-day female    11 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    20 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    89 digestive system, larvae L3 wandering    196 digestive system, 1-day adult    24 digestive system, 4-day adult    25 digestive system, 20-day adult    22 fat body, larvae L3 wandering    12 fat body, white prepupae    55 fat body, pupae P8    66 carcass, larvae L3 wandering    344 carcass, 1-day adult    41 carcass, 4-day adult    33 carcass, 20-day adult    24 ovary, virgin 4-day female    13 ovary, mated 4-day female    12 testis, mated 4-day male    16 accessory gland, mated 4-day male    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed during late larval stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr    38 embryo 06-08hr    56 embryo 08-10hr    62 embryo 10-12hr    59 embryo 12-14hr    61 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2    29 larva L3 12hr old    27 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    156 white prepupae new    252 white prepupae 12hr    154 white prepupae 24hr    112 pupae 2d postWPP    85 pupae 3d postWPP    43 pupae 4d postWPP    28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr  (38) embryo 06-08hr  (56) embryo 08-10hr  (62) embryo 10-12hr  (59) embryo 12-14hr  (61) embryo 14-16hr  (28) embryo 16-18hr  (29) embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2  (29) larva L3 12hr old  (27) larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (59) larva L3 puffstage 7-9  (156) white prepupae new  (252) white prepupae 12hr  (154) white prepupae 24hr  (112) pupae 2d postWPP  (85) pupae 3d postWPP  (43) pupae 4d postWPP  (28) adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr    38 embryo 06-08hr    56 embryo 08-10hr    62 embryo 10-12hr    59 embryo 12-14hr    61 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2    29 larva L3 12hr old    27 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9  (156) white prepupae new  (252) white prepupae 12hr  (154) white prepupae 24hr  (112) pupae 2d postWPP    85 pupae 3d postWPP    43 pupae 4d postWPP    28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr    38 embryo 06-08hr    56 embryo 08-10hr    62 embryo 10-12hr    59 embryo 12-14hr    61 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2    29 larva L3 12hr old    27 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    156 white prepupae new    252 white prepupae 12hr    154 white prepupae 24hr    112 pupae 2d postWPP    85 pupae 3d postWPP    43 pupae 4d postWPP    28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr    38 embryo 06-08hr    56 embryo 08-10hr    62 embryo 10-12hr    59 embryo 12-14hr    61 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2    29 larva L3 12hr old    27 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    156 white prepupae new    252 white prepupae 12hr    154 white prepupae 24hr    112 pupae 2d postWPP    85 pupae 3d postWPP    43 pupae 4d postWPP    28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr  (38) embryo 06-08hr  (56) embryo 08-10hr  (62) embryo 10-12hr  (59) embryo 12-14hr  (61) embryo 14-16hr  28 embryo 16-18hr  29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2  29 larva L3 12hr old  27 larva L3 puffstage 1-2  (33) larva L3 puffstage 3-6  (59) larva L3 puffstage 7-9  (156) white prepupae new  (252) white prepupae 12hr  (154) white prepupae 24hr  (112) pupae 2d postWPP  (85) pupae 3d postWPP  (43) pupae 4d postWPP  28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr    38 embryo 06-08hr    56 embryo 08-10hr    62 embryo 10-12hr    59 embryo 12-14hr    61 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2    29 larva L3 12hr old    27 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9  (156) white prepupae new  (252) white prepupae 12hr  (154) white prepupae 24hr  112 pupae 2d postWPP    85 pupae 3d postWPP    43 pupae 4d postWPP    28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    18 embryo 02-04hr    19 embryo 04-06hr    38 embryo 06-08hr    56 embryo 08-10hr    62 embryo 10-12hr    59 embryo 12-14hr    61 embryo 14-16hr    28 embryo 16-18hr    29 embryo 18-20hr    23 embryo 20-22hr    18 embryo 22-24hr    24 larva L1    17 larva L2    29 larva L3 12hr old    27 larva L3 puffstage 1-2    33 larva L3 puffstage 3-6    59 larva L3 puffstage 7-9    156 white prepupae new    252 white prepupae 12hr    154 white prepupae 24hr    112 pupae 2d postWPP    85 pupae 3d postWPP    43 pupae 4d postWPP    28 adult male 01day    23 adult male 05day    19 adult male 30day    15 adult female 01day    21 adult female 05day    24 adult female 30day    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    63 embryonic 1182-4H    105 embryonic GM2    104 embryonic Kc167    114 embryonic S1    82 embryonic S3    64 leg disc CME L1    74 wing disc CME-W2    74 wing disc ML-DmD8    93 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    82 wing disc ML-DmD21    50 wing disc ML-DmD32    107 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    105 CNS ML-DmBG1-c1    90 CNS ML-DmBG2-c2    93 tumorous blood cells mbn2    105 ovary fGS/OSS    94 ovary OSC    85 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (130) Schneider line 2 Sg4  (63) embryonic 1182-4H  (105) embryonic GM2  (104) embryonic Kc167  (114) embryonic S1  (82) embryonic S3  (64) leg disc CME L1  (74) wing disc CME-W2  (74) wing disc ML-DmD8  (93) wing disc ML-DmD9  (93) wing disc ML-DmD16-c3  (82) wing disc ML-DmD21  (50) wing disc ML-DmD32  (107) haltere disc ML-DmD17-c3  (82) eye-antennal disc ML-DmD11  (60) antennal disc ML-DmD20-c5  (76) mixed discs ML-DmD4-c1  (105) CNS ML-DmBG1-c1  (90) CNS ML-DmBG2-c2  (93) tumorous blood cells mbn2  (105) ovary fGS/OSS  (94) ovary OSC  (85) ovary OSS  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (130) Schneider line 2 Sg4    63 embryonic 1182-4H  105 embryonic GM2  104 embryonic Kc167  (114) embryonic S1    82 embryonic S3    64 leg disc CME L1    74 wing disc CME-W2    74 wing disc ML-DmD8    93 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    82 wing disc ML-DmD21    50 wing disc ML-DmD32  107 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1  105 CNS ML-DmBG1-c1    90 CNS ML-DmBG2-c2    93 tumorous blood cells mbn2  105 ovary fGS/OSS    94 ovary OSC    85 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    63 embryonic 1182-4H    105 embryonic GM2    104 embryonic Kc167    114 embryonic S1    82 embryonic S3    64 leg disc CME L1    74 wing disc CME-W2    74 wing disc ML-DmD8    93 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    82 wing disc ML-DmD21    50 wing disc ML-DmD32    107 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    105 CNS ML-DmBG1-c1    90 CNS ML-DmBG2-c2    93 tumorous blood cells mbn2    105 ovary fGS/OSS    94 ovary OSC    85 ovary OSS    58 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    63 embryonic 1182-4H    105 embryonic GM2    104 embryonic Kc167    114 embryonic S1    82 embryonic S3    64 leg disc CME L1    74 wing disc CME-W2    74 wing disc ML-DmD8    93 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    82 wing disc ML-DmD21    50 wing disc ML-DmD32    107 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    105 CNS ML-DmBG1-c1    90 CNS ML-DmBG2-c2    93 tumorous blood cells mbn2    105 ovary fGS/OSS    94 ovary OSC    85 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (130) Schneider line 2 Sg4  (63) embryonic 1182-4H  (105) embryonic GM2  (104) embryonic Kc167  (114) embryonic S1  (82) embryonic S3  (64) leg disc CME L1  (74) wing disc CME-W2  (74) wing disc ML-DmD8  (93) wing disc ML-DmD9  (93) wing disc ML-DmD16-c3  (82) wing disc ML-DmD21  (50) wing disc ML-DmD32  (107) haltere disc ML-DmD17-c3  (82) eye-antennal disc ML-DmD11  (60) antennal disc ML-DmD20-c5  (76) mixed discs ML-DmD4-c1  (105) CNS ML-DmBG1-c1  (90) CNS ML-DmBG2-c2  (93) tumorous blood cells mbn2  (105) ovary fGS/OSS  (94) ovary OSC  (85) ovary OSS  (58) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  130 Schneider line 2 Sg4    63 embryonic 1182-4H  105 embryonic GM2  104 embryonic Kc167  114 embryonic S1    82 embryonic S3    64 leg disc CME L1    74 wing disc CME-W2    74 wing disc ML-DmD8    93 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    82 wing disc ML-DmD21    50 wing disc ML-DmD32  107 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1  105 CNS ML-DmBG1-c1    90 CNS ML-DmBG2-c2    93 tumorous blood cells mbn2  105 ovary fGS/OSS    94 ovary OSC    85 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    130 Schneider line 2 Sg4    63 embryonic 1182-4H    105 embryonic GM2    104 embryonic Kc167    114 embryonic S1    82 embryonic S3    64 leg disc CME L1    74 wing disc CME-W2    74 wing disc ML-DmD8    93 wing disc ML-DmD9    93 wing disc ML-DmD16-c3    82 wing disc ML-DmD21    50 wing disc ML-DmD32    107 haltere disc ML-DmD17-c3    82 eye-antennal disc ML-DmD11    60 antennal disc ML-DmD20-c5    76 mixed discs ML-DmD4-c1    105 CNS ML-DmBG1-c1    90 CNS ML-DmBG2-c2    93 tumorous blood cells mbn2    105 ovary fGS/OSS    94 ovary OSC    85 ovary OSS    58 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    44 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    146 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    106 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    123 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    65 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    64 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (48) cold shock, 4-day adult  (44) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3  (41) Cadmium 50 mM 12 hrs, larvae L3  (146) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3  (106) Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3  (123) Zinc 4.5 mM 48 hrs, 4-day adult  (56) Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3  (65) Ethanol 10% 3 hrs, larvae L3  (55) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (64) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    44 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3  (146) Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3  106 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3  (123) Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    65 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    64 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    44 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    146 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    106 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    123 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    65 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    64 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    44 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    146 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    106 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    123 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    65 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    64 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (48) cold shock, 4-day adult  (44) heat shock, 4-day adult  (39) Cadmium 50 mM 6 hrs, larvae L3  (41) Cadmium 50 mM 12 hrs, larvae L3  (146) Cadmium 50 mM 48 hrs, 4-day adult  (47) Cadmium 100 mM 48 hrs, 4-day adult  (33) Copper 0.5 mM 12 hrs, larvae L3  (106) Copper 15 mM 48 hrs, 4-day adult  (43) Zinc 5 mM 12 hrs, larvae L3  (123) Zinc 4.5 mM 48 hrs, 4-day adult  (56) Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3  (65) Ethanol 10% 3 hrs, larvae L3  (55) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (64) Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult  (39) Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    44 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3  (146) Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3  106 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3  123 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    65 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    64 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    48 cold shock, 4-day adult    44 heat shock, 4-day adult    39 Cadmium 50 mM 6 hrs, larvae L3    41 Cadmium 50 mM 12 hrs, larvae L3    146 Cadmium 50 mM 48 hrs, 4-day adult    47 Cadmium 100 mM 48 hrs, 4-day adult    33 Copper 0.5 mM 12 hrs, larvae L3    106 Copper 15 mM 48 hrs, 4-day adult    43 Zinc 5 mM 12 hrs, larvae L3    123 Zinc 4.5 mM 48 hrs, 4-day adult    56 Ethanol 2.5% 3 hrs, larvae L3    18 Ethanol 5% 3 hrs, larvae L3    65 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    64 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    23 Caffeine 25 mg/ml 48 hrs, 4-day adult    39 Paraquat 5 mM 48 hrs, 4-day adult    22 Paraquat 10 mM 48 hrs, 4-day adult    21 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_25 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD12912 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035772 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8582-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Sh3βCC01823 viable, with Scer\GAL4pnr-MD237 Sh3βGD13975 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Sh3β Class Mutagen Stocks Known lesion Sh3βMB03704 1 -- Sh3βNP1593 1 -- Sh3βCC01823 P-element activity 0 Yes Sh3βCPTI002892 piggyBac transposase 0 Yes Sh3βDOr P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sh3β Class Mutagen Stocks Known lesion Sh3βGD13975 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Sh3βKK108429 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)0463 (Mohan et al., 2007) Df(3L)Exel8104 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Sh3βMB03704 No P{GawB}Sh3βNP1593 No miscellaneous insertions P{(loxP.w.-110+276)w}Sh3βDOr NA P{PTT-GC}Sh3βCC01823 NA PBac{754.P.FSVS-0}Sh3βCPTI002892 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data before: 2006)
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Sh3β - 14-3-3ε experimental knowledge based (Guruharsha et al., 2011) Sh3β - ATPsyn-β experimental knowledge based (Guruharsha et al., 2011) Sh3β - Act57B experimental knowledge based (Guruharsha et al., 2011) Sh3β - Akap200 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Ald experimental knowledge based (Guruharsha et al., 2011) Sh3β - AnxB10 experimental knowledge based (Guruharsha et al., 2011) Sh3β - AnxB9 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Bacc experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG10265 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG10638 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG10863 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG11267 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG13887 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG14715 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG14968 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG16817 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG1707 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG17568 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Sh3β - CG18335 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG1910 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG1941 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG2004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG2767 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG2852 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG2862 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG30339 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Sh3β - CG31917 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG40160 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG4511 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG4598 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG5355 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG5380 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG5986 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG6084 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG7054 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG7091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG7911 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG7924 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG8036 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG8117 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG8680 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - CG8891 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Sh3β - CG8993 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG9391 experimental knowledge based (Guruharsha et al., 2011) Sh3β - CG9705 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Chd64 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Cpr11B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Crc experimental knowledge based (Guruharsha et al., 2011) Sh3β - Cyp1 experimental knowledge based (Guruharsha et al., 2011) Sh3β - D1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Df31 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Dim1 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Sh3β - ERp60 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Eb1 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Ef2b experimental knowledge based (Guruharsha et al., 2011) Sh3β - EndoGI experimental knowledge based (Guruharsha et al., 2011) Sh3β - Eno experimental knowledge based (Guruharsha et al., 2011) Sh3β - FK506-bp2 experimental knowledge based (Guruharsha et al., 2011) Sh3β - FKBP59 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Fim experimental knowledge based (Guruharsha et al., 2011) Sh3β - Fkbp13 experimental knowledge based (Guruharsha et al., 2011) Sh3β - GstE6 experimental knowledge based (Guruharsha et al., 2011) Sh3β - GstO3 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Hop experimental knowledge based (Guruharsha et al., 2011) Sh3β - Hsc70Cb experimental knowledge based (Guruharsha et al., 2011) Sh3β - Inos experimental knowledge based (Guruharsha et al., 2011) Sh3β - Jupiter experimental knowledge based (Guruharsha et al., 2011) Sh3β - Mdh2 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Mip anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Moe experimental knowledge based (Guruharsha et al., 2011) Sh3β - Nacα experimental knowledge based (Guruharsha et al., 2011) Sh3β - Nlp experimental knowledge based (Guruharsha et al., 2011) Sh3β - Npc2g anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Ntf-2 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Oat anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Ote anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - PHGPx experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Sh3β - Pdi experimental knowledge based (Guruharsha et al., 2011) Sh3β - Pgd experimental knowledge based (Guruharsha et al., 2011) Sh3β - Pgk experimental knowledge based (Guruharsha et al., 2011) Sh3β - Pglym78 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Proct anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Prosα1 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Prosα4 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Prosα6 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Prosα7 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Prosβ5 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Prx2540-2 experimental knowledge based (Guruharsha et al., 2011) Sh3β - RhoGDI experimental knowledge based (Guruharsha et al., 2011) Sh3β - RpS21 experimental knowledge based (Guruharsha et al., 2011) Sh3β - RpS5a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Snx3 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Sh3β - Sod experimental knowledge based (Guruharsha et al., 2011) Sh3β - Spc25 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - TER94 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Tal experimental knowledge based (Guruharsha et al., 2011) Sh3β - Tctp experimental knowledge based (Guruharsha et al., 2011) Sh3β - TpnC25D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - Trx-2 experimental knowledge based (Guruharsha et al., 2011) Sh3β - Uch experimental knowledge based (Guruharsha et al., 2011) Sh3β - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - ave anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - awd experimental knowledge based (Guruharsha et al., 2011) Sh3β - capt experimental knowledge based (Guruharsha et al., 2011) Sh3β - chic experimental knowledge based (Guruharsha et al., 2011) Sh3β - cib experimental knowledge based (Guruharsha et al., 2011) Sh3β - dUTPase experimental knowledge based (Guruharsha et al., 2011) Sh3β - dod experimental knowledge based (Guruharsha et al., 2011) Sh3β - eEF1δ experimental knowledge based (Guruharsha et al., 2011) Sh3β - eIF-1A experimental knowledge based (Guruharsha et al., 2011) Sh3β - eIF-5A experimental knowledge based (Guruharsha et al., 2011) Sh3β - fabp experimental knowledge based (Guruharsha et al., 2011) Sh3β - fbp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - l(2)37Cb experimental knowledge based (Guruharsha et al., 2011) Sh3β - mus209 experimental knowledge based (Guruharsha et al., 2011) Sh3β - regucalcin experimental knowledge based (Guruharsha et al., 2011) Sh3β - scf experimental knowledge based (Guruharsha et al., 2011) Sh3β - scu experimental knowledge based (Guruharsha et al., 2011) Sh3β - smt3 experimental knowledge based (Guruharsha et al., 2011) Sh3β - tub anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sh3β - yip2 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sh3β allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035772 DroID - A comprehensive database of gene and protein interactions. • FBgn0035772 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38820
Orthologs
OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6TXCCK Dipteran inclusive ortholog search EOG625637 Insect inclusive ortholog search EOG62BW67 Arthropod inclusive ortholog search EOG612JP4 Metazoa inclusive ortholog search EOG6D5FSQ
Orthologs in Drosophila Species (EOG6TXCCK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sh3β     Drosophila simulans   Dsim\GD13062 Y   Drosophila sechellia   Dsec\GM13764 Y   Drosophila erecta   Dere\GG14969 Y   Drosophila yakuba   Dyak\GE20417 Y   Drosophila ananassae   Dana\GF23792 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21178 Y   Drosophila persimilis   Dper\GL24309 Y   Drosophila willistoni   Dwil\GK25310 Y   Drosophila virilis   Dvir\GJ12365 Y   Drosophila mojavensis   Dmoj\GI12464 Y   Drosophila grimshawi   Dgri\GH16617 Y
Orthologs in non-Drosophila Dipterans (EOG625637)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007990   Anopheles gambiae Malaria mosquito  Agam\AGAP007362   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013453
Orthologs in non-Dipteran Insects (EOG62BW67)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC551916   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003706   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26800   Camponotus floridanus Florida carpenter ant  Cflo\CFLO16599   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12412   Linepithema humile Argentine ant  Lhum\LH12543   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21382   Solenopsis invicta Red fire ant  Sinv\SINV18062   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008600   Bombyx mori Silkmoth  Bmor\BGIBMGA004706   Pediculus humanus Human body louse  Phum\PHUM150100   Tribolium castaneum Red flour beetle  Tcas\TC014808
Orthologs in non-Insect Arthropods (EOG612JP4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CO1   Ixodes scapularis Deer tick  Isca\ISCW020127
Orthologs in non-Arthropod Metazoa (EOG6D5FSQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y105E8A.1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018732gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015280gn   Danio rerio Zebrafish  Drer\sh3bgrl2   Danio rerio Zebrafish  Drer\ENSDARG00000036876   Danio rerio Zebrafish  Drer\ENSDARG00000058302   Danio rerio Zebrafish  Drer\sh3bgr   Danio rerio Zebrafish  Drer\sh3bgrl3   Xenopus tropicalis Western clawed frog  Xtro\sh3bgrl2   Xenopus tropicalis Western clawed frog  Xtro\sh3bgr   Xenopus tropicalis Western clawed frog  Xtro\sh3bgrl3   Gallus gallus Domestic chicken  Ggal\SH3BGRL2   Gallus gallus Domestic chicken  Ggal\SH3BGRL   Gallus gallus Domestic chicken  Ggal\SH3BGR   Gallus gallus Domestic chicken  Ggal\SH3BGRL3   Mus musculus House mouse  Mmus\Sh3bgrl   Mus musculus House mouse  Mmus\Sh3bgr   Mus musculus House mouse  Mmus\ENSMUSG00000032261   Rattus norvegicus Norway rat  Rnor\Sh3bgr   Rattus norvegicus Norway rat  Rnor\RGD1562039   Rattus norvegicus Norway rat  Rnor\Sh3bgrl3   Rattus norvegicus Norway rat  Rnor\Sh3bgrl   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000009613   Homo sapiens Human  Hsap\SH3BGR   Homo sapiens Human  Hsap\SH3BGRL2   Homo sapiens Human  Hsap\SH3BGRL   Homo sapiens Human  Hsap\SH3BGRL3
Human Orthologs (4)
Gene OMIM HGNC Hsap\SH3BGR     Hsap\SH3BGRL2     Hsap\SH3BGRL     Hsap\SH3BGRL3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13062 Drosophila sechellia Dsec\GM13764 Drosophila erecta Dere\GG14969 Drosophila yakuba Dyak\GE20417 Drosophila ananassae Dana\GF23792 Drosophila pseudoobscura pseudoobscura Dpse\GA21178 Drosophila persimilis Dper\GL24309 Drosophila willistoni Dwil\GK25310 Drosophila virilis Dvir\GJ12365 Drosophila mojavensis Dmoj\GI12464 Drosophila grimshawi Dgri\GH16617
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	23637 w1118; Mi{ET1}Sh3βMB03704
Kyoto	104040 y* w*; P{GawB}Sh3βNP1593 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v107823 P{KK108429}VIE-260B v35970 w1118; P{GD13975}v35970 v35971 w1118; P{GD13975}v35971/TM3
Genomic Clones ( 2 )
	BACR09E21 BACR11B04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD12912
Other clones	DPiM_LD12912
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17585 GH23661 LD10257 LP21905 RE23602 RE34970 RE35702 RE53937 RE64827 RE72111 RH15927 SD14189
Other clones	19278 19342 34882 40628 42844 59400 61490 61659 70516 73486 74381 107102 118883 125021 166681 214509.60 282413 521801 521808 571118 bs60b07 CK01.53A.D12 CK01.73B.G11 CK01.84B.H1 CK01.98C.D1 CK01.123B.H1 Dmel_dig_019036_0717_0556 EK021101 EK042946 EK057821 EK068829 EK076110 EK093829 EK129345 EK132316 EK186735 EK187229 EK197844 EK202443 EK204111 EK271137 EK308134 EN01053 EN01060 EN11602 EN16120 EP04933 EP19405 ESG014a.E21_D05 ESG015a.E21_A09 ESG015c.E21.1_G11 ESG0111d.B21.1_F10 FGH107H09 GM04811
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035772 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38820
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Sh3β CG8582 (FlyBase, 1996-)
Source for database merge of
Additional comments	Source for identity of Sh3β CG8582 was sequence comparison (date:001125). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139855 NM_168210 NM_001202126 NM_001202127 NM_001202128 RefSeq (Proteins) • NP_648112 NP_729248 NP_001189055 NP_001189056 NP_001189057 DDBJ / EMBL / GenBank • AA438597 AAF50570 AAL28710 AAN12061 ADV37492 ADV37493 ADV37494 AJ272505 AW942252 AY061162 CAB76915 Entrez Gene - A searchable database of RefSeq genes. • 38820 UniProtKB/Swiss-Prot • Q9NFP5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SH3-binding, glutamic acid-rich protein (IPR006993) Thioredoxin-like fold (IPR012336) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD12912
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035772 DroID - A comprehensive database of gene and protein interactions. • FBgn0035772 DRSC - Results from RNAi screens. • FBgn0035772 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035772 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8582-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035772 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38820 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38820 modMine - Data generated by the modENCODE project. • FBgn0035772
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	CG8582 (Quinones-Coello, 2007, Keleman et al., 2009.8.5, Cammarato et al., 2011) LD12912 (Herold et al., 2003) Sh3beta (Buszczak et al., 2007, Quinones-Coello, 2007, Mohan et al., 2007, Silicheva et al., 2010) Sh3β (Ocorr et al., 2007, Mohan et al., 2007, Fu and Whitfield, 2012) SH3β (Akasaka et al., 2006, Grossman et al., 2011)
Name Synonym	Sh3beta (Cammarato et al., 2011) Sh3β
Secondary FlyBase IDs
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 9 ) FlyBase analysis  ( 4 ) Website  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 3 )
	Fu and Whitfield, 2012, PLoS ONE 7(5): e29157 Genes associated with honey bee behavioral maturation affect clock-dependent and -independent aspects of daily rhythmic activity in fruit flies. [FBrf0218339] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Grossman et al., 2011, PLoS Genet. 7(11): e1002344 Over-Expression of DSCAM and COL6A2 Cooperatively Generates Congenital Heart Defects. [FBrf0216615] Show all research papers ...