Gene model reviewed during 5.45
Interacts with Uba3.
Both the N-terminal docking peptide and the catalytic core domain must bind the Uba3-Ula1 complex simultaneously for optimal transfer of Nedd8.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\UbcE2M using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\UbcE2M in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: CG7375 anon-WO0118547.309
Originally named 'Ubc12' in FBrf0215574 after human/vertebrate 'Ubc12' , but renamed to 'UbcE2M' to (i) avoid confusion with an extant Ubc naming system where the number after the 'Ubc' prefix reflects the order the Ubc genes were characterized; and (ii) reflect the current human gene symbol (at the HGNC).
Source for merge of CG7375 anon-WO0118547.309 was sequence comparison ( date:051113 ).
Area matching Drosophila EST AI259832. This EST overlaps ESTS AA990765 and has sequence similarity to Human ubiquitin conjugating enzyme 12 gene. Probable intron in gene represented by EST AI259832.
Named 'Ubc12' based on the symbol of the human/vertebrate ortholog.