FB2020_06, released Dec 22, 2020

Gene: Dmel\UbcE2M

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General Information
Symbol
Dmel\UbcE2M
Species
D. melanogaster
Name
NEDD8-conjugating enzyme UbcE2M
Annotation Symbol
CG7375
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035853
Gene Model Status
Current
Stock Availability
10 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

Ubc12

Key Links
Genomic Location
Cytogenetic map
66B12-66B12
Sequence location
3L:8,195,847..8,197,987 [-]
Recombination map

3-22

RefSeq locus
NT_037436 REGION:8195847..8197987
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables NEDD8 conjugating enzyme activity
inferred from direct assay
(Du et al., 2011)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables NEDD8 transferase activity
inferred from sequence or structural similarity with UniProtKB:Q9XVK5
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000630367
(assigned by GO_Central )
(Gaudet et al., 2011)
enables ubiquitin conjugating enzyme activity
inferred from biological aspect of ancestor with PANTHER:PTN002514495
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in negative regulation of smoothened signaling pathway
inferred from mutant phenotype
(Du et al., 2011)
involved_in positive regulation of smoothened signaling pathway
inferred from mutant phenotype
(Park et al., 2016)
involved_in protein neddylation
inferred from direct assay
(Du et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in cellular protein modification process
inferred from sequence or structural similarity with UniProtKB:P61081
(assigned by UniProt )
(UniProt Curators, 2002-)
involved_in protein neddylation
inferred from sequence or structural similarity with UniProtKB:Q9XVK5
(assigned by UniProt )
(UniProt Curators, 2002-)
inferred from biological aspect of ancestor with PANTHER:PTN000630367
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein polyubiquitination
inferred from biological aspect of ancestor with PANTHER:PTN002514495
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002514495
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily. (Q9VSF3)
Protein Signatures (InterPro)
Summaries
Pathway (FlyBase)
Negative Regulators of Hedgehog Signaling Pathway -
Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
Positive Regulators of Imd Signaling Pathway -
Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)
Gene Group (FlyBase)
NEDD8 TRANSFERASES -
NEDD8 transferases catalyse the transfer of the ubiquitin-like protein NEDD8 from one substrate to another. They include NEDD8 conjugating (E2) enzymes and NEDD8 ligase (E3) enzymes, which act sequentially in a process analogous to ubiquitination, and result in covalent attachment of NEDD8 to target proteins. Neddylation results in activation of members of the cullin-RING family of ubiquitin E3 ligases, which appear to be the major NEDD8 targets in the cell. (Adapted from PMID:25531226.)
Protein Function (UniProtKB)
Accepts the ubiquitin-like protein Nedd8 from the Uba3-APP-BP1 E1 complex and catalyzes its covalent attachment to other proteins. Required for Cul1 and Cul3 neddylation. Negatively regulates full-length ci stability and hedgehog signaling.
(UniProt, Q9VSF3)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\UbcE2M for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
UbcE2M-RA
FBtr0076722
NM_139930
913
181
UbcE2M-RB
FBtr0332138
NM_001274638
916
181
UbcE2M-RC
FBtr0332139
NM_001274639
1729
181
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
UbcE2M-PA
FBpp0076445
20.7
181
7.21
NP_648187
AAF50468
UbcE2M-PB
FBpp0304448
20.7
181
7.21
NP_001261567
AGB94262
UbcE2M-PC
FBpp0304449
20.7
181
7.21
NP_001261568
AGB94263
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

181 aa isoforms: UbcE2M-PA, UbcE2M-PB, UbcE2M-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with Uba3.

(UniProt, Q9VSF3)
Domain

Both the N-terminal docking peptide and the catalytic core domain must bind the Uba3-Ula1 complex simultaneously for optimal transfer of Nedd8.

(UniProt, Q9VSF3)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\UbcE2M using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\UbcE2M in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of UbcE2M
Transgenic constructs containing regulatory region of UbcE2M
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\UBE2M
14 of 15
Yes
Yes
Hsap\UBE2F
2 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ube2m
14 of 15
Yes
Yes
Mmus\Ube2f
2 of 15
No
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Ube2m
11 of 13
Yes
Yes
Rnor\Ube2f
2 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\ube2m
12 of 12
Yes
Yes
Xtro\ube2f
3 of 12
No
Yes
Danio rerio (Zebrafish) (2)
Drer\si:ch1073-205c8.3
8 of 15
Yes
Yes
Drer\ube2f
5 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\ubc-12
4 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (2)
Atha\AT2G18600
9 of 9
Yes
Yes
Atha\RCE1
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\UBC12
14 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\ubc12
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190G9F )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003705
Drosophila simulans
Dsim\GD13010
Drosophila sechellia
Dsec\GM24960
Drosophila erecta
Dere\GG15103
Drosophila yakuba
Dyak\GE21328
Drosophila ananassae
Dana\GF24700
Drosophila pseudoobscura pseudoobscura
Dpse\GA20305
Drosophila persimilis
Dper\GL22563
Drosophila willistoni
Dwil\GK10814
Drosophila virilis
Dvir\GJ12887
Drosophila mojavensis
Dmoj\GI16632
Drosophila grimshawi
Dgri\GH15981
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150BM8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013038
Glossina morsitans
Tsetse fly
Gmor\GMOY011947
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01423
Mayetiola destructor
Hessian fly
Mdes\Mdes001608
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009026
Anopheles darlingi
American malaria mosquito
Adar\ADAC004474
Anopheles gambiae
Malaria mosquito
Agam\AGAP005916
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007408
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0DKY )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007862
Danaus plexippus
Monarch butterfly
Dple\DPOGS213102-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006555
Apis florea
Little honeybee
Aflo\2287096708
Apis mellifera
Western honey bee
Amel\LOC409225
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13514
Bombus terrestris
Buff-tailed bumblebee
Bter\15204540
Linepithema humile
Argentine ant
Lhum\LH10585
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001542
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG016437
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09810
Tribolium castaneum
Red flour beetle
Tcas\TC003234
Pediculus humanus
Human body louse
Phum\PHUM581720
Rhodnius prolixus
Kissing bug
Rpro\RPRC007710
Cimex lectularius
Bed bug
Clec\CLEC001244
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002132
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03208
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DIL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007246
Ixodes scapularis
Black-legged tick
Isca\ISCW011884
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82933.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur31g01490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur101g00020
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_44414
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N8A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ube2m
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ube2f
Ciona intestinalis
Vase tunicate
Cint\LOC100177347
Ciona intestinalis
Vase tunicate
Cint\LOC100181334
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000026950
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003812
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (31)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ben
2 of 10
CG3473
2 of 10
CG5823
2 of 10
CG7220
2 of 10
CG8188
2 of 10
CG14739
2 of 10
Ubc4
2 of 10
UbcE2H
2 of 10
Uev1A
2 of 10
vih
2 of 10
CG2574
1 of 10
CG2924
1 of 10
CG4502
1 of 10
CG5440
1 of 10
CG7656
1 of 10
CG10254
1 of 10
CG10862
1 of 10
CG16894
1 of 10
CG17030
1 of 10
CG40045
1 of 10
CG46338
1 of 10
eff
1 of 10
Kua
1 of 10
lwr
1 of 10
morgue
1 of 10
Ubc2
1 of 10
Ubc6
1 of 10
Ubc7
1 of 10
Ubc10
1 of 10
Ubc84D
1 of 10
Ubc87F
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    UBE2M; ubiquitin conjugating enzyme E2 M
    14 of 15
    603173
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        UbcE2M - AnxB10
        experimental knowledge based
        (Guruharsha et al., 2011)
        UbcE2M - Aos1
        experimental knowledge based
        (Guruharsha et al., 2011)
        UbcE2M - CG15717
        experimental knowledge based
        (Guruharsha et al., 2011)
        UbcE2M - CG7675
        experimental knowledge based
        (Guruharsha et al., 2011)
        UbcE2M - Uba2
        experimental knowledge based
        (Guruharsha et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Interacts with Uba3.
        (UniProt, Q9VSF3 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Negative Regulators of Hedgehog Signaling Pathway -
        Negative regulators of hedgehog signaling down-regulate the pathway, resulting in the repression of transcription of hh-responsive genes.
        Positive Regulators of Imd Signaling Pathway -
        Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-22

        Cytogenetic map
        66B12-66B12
        Sequence location
        3L:8,195,847..8,197,987 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        66B12-66B12
        Limits computationally determined from genome sequence between P{lacW}Nmtj1C7 and P{lacW}l(3)L0139L0139
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location

        3-22

        (FlyBase, 2016)

        3-19.0

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (10)
        Genomic Clones (15)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (124)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of

        Source for identity of: Ubc12 CG7375

        (Du et al., 2011)

        Source for identity of: UbcE2M Ubc12

        (FlyBase, 2009-)
        Source for database merge of

        Source for merge of: CG7375 anon-WO0118547.309

        (FlyBase, 1996-)
        Additional comments

        Originally named 'Ubc12' in FBrf0215574 after human/vertebrate 'Ubc12' , but renamed to 'UbcE2M' to (i) avoid confusion with an extant Ubc naming system where the number after the 'Ubc' prefix reflects the order the Ubc genes were characterized; and (ii) reflect the current human gene symbol (at the HGNC).

        (FlyBase, 2009-)

        Source for merge of CG7375 anon-WO0118547.309 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Other Comments

        Area matching Drosophila EST AI259832. This EST overlaps ESTS AA990765 and has sequence similarity to Human ubiquitin conjugating enzyme 12 gene. Probable intron in gene represented by EST AI259832.

        (Davies, 2001.3.15)
        Origin and Etymology
        Discoverer
        Etymology

        Named 'Ubc12' based on the symbol of the human/vertebrate ortholog.

        (Du et al., 2011)
        Identification
        External Crossreferences and Linkouts ( 46 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (11)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (53)