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Gene Dmel\Cdc6

General Information
Symbol	Dmel\Cdc6	Species	D. melanogaster
Name	Cdc6	Annotation symbol	CG5971
Feature type	protein_coding_gene	FlyBase ID	FBgn0035918
Gene Model Status	Current	Stock availability	1 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66D9-66D9	Sequence location	3L:8,624,609..8,627,181 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cdc6 is referred to in FlyBase by the symbol Dmel\Cdc6 (CG5971, FBgn0035918). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: DNA clamp loader activity. Based on sequence similarity, it is predicted to be involved in the biological process: pre-replicative complex assembly. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, core; CDC6, C-terminal; Cell division protein Cdc6; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1631019_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Cdc6. Gene sequence location is 3L:8624609..8627181.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA10563 BKN27932
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66D9-66D9   Limits computationally determined from genome sequence between P{lacW}foij8E8 and P{PZ}SrpRβrK561&P{lacW}l(3)j5B6j5B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cdc6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cdc6-RA FBtr0076647  NM_139990   2495   662
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cdc6-PA   FBpp0076371   75.1   662   9.71     NP_648247   AAF50387
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) CDC6, C-terminal (IPR015163) Cell division protein Cdc6 (IPR016314) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391619   AA941117   AA949263   AA950172   AA950203   AA951933   AE014296 AAF50387   AI259651   AI455669   AI456894   AI515230   AI515751   AI520103   AI534637   AI543935   AW942717   AY051722 AAK93146   BI165058   BI172892   BI212792   BI213785   BI215413   BI357562   BI357890   BI361773   BI361809   BI362670   BI363916   BI365474   BI366902   BI375958   BI375991   BI483872   CO177383   CO178873   CO186800   CO190150   CO261994   CO270594   CO284341   CO288148   EC068410   EC070119   EC071030   EC214185   EC217648   EC217779   EC218647   EC241547   EC242933   EC251068   EC252465   EV577475
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VSM9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035918    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035918 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035918 expression level Developmental Stage   Expression Level embryo 00-02hr    6662 embryo 02-04hr    9051 embryo 04-06hr    5568 embryo 06-08hr    3779 embryo 08-10hr    3384 embryo 10-12hr    2470 embryo 12-14hr    1784 embryo 14-16hr    1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day    2312 adult female 30day    2546 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6662) embryo 02-04hr  (9051) embryo 04-06hr  (5568) embryo 06-08hr  (3779) embryo 08-10hr  (3384) embryo 10-12hr  (2470) embryo 12-14hr  (1784) embryo 14-16hr  (1916) embryo 16-18hr  (1398) embryo 18-20hr  (820) embryo 20-22hr  (1202) embryo 22-24hr  (1166) larva L1  (349) larva L2  (365) larva L3 12hr old  (322) larva L3 puffstage 1-2  (294) larva L3 puffstage 3-6  (336) larva L3 puffstage 7-9  (357) white prepupae new  (273) white prepupae 12hr  (450) white prepupae 24hr  (291) pupae 2d postWPP  (130) pupae 3d postWPP  (117) pupae 4d postWPP  (341) adult male 01day  (135) adult male 05day  (171) adult male 30day  (145) adult female 01day  (1088) adult female 05day  (2312) adult female 30day  (2546) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6662) embryo 02-04hr  (9051) embryo 04-06hr  (5568) embryo 06-08hr  (3779) embryo 08-10hr  (3384) embryo 10-12hr  (2470) embryo 12-14hr  (1784) embryo 14-16hr  (1916) embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day  (2312) adult female 30day  (2546) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6662 embryo 02-04hr    9051 embryo 04-06hr    5568 embryo 06-08hr    3779 embryo 08-10hr    3384 embryo 10-12hr    2470 embryo 12-14hr    1784 embryo 14-16hr    1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day    2312 adult female 30day    2546 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6662 embryo 02-04hr    9051 embryo 04-06hr    5568 embryo 06-08hr    3779 embryo 08-10hr    3384 embryo 10-12hr    2470 embryo 12-14hr    1784 embryo 14-16hr    1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day    2312 adult female 30day    2546 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035918 expression level Developmental Stage   Expression Level embryo 00-02hr    6662 embryo 02-04hr    9051 embryo 04-06hr    5568 embryo 06-08hr    3779 embryo 08-10hr    3384 embryo 10-12hr    2470 embryo 12-14hr    1784 embryo 14-16hr    1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day    2312 adult female 30day    2546 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6662) embryo 02-04hr  (9051) embryo 04-06hr  (5568) embryo 06-08hr  (3779) embryo 08-10hr  (3384) embryo 10-12hr  (2470) embryo 12-14hr  (1784) embryo 14-16hr  (1916) embryo 16-18hr  (1398) embryo 18-20hr  (820) embryo 20-22hr  (1202) embryo 22-24hr  (1166) larva L1  (349) larva L2  (365) larva L3 12hr old  (322) larva L3 puffstage 1-2  (294) larva L3 puffstage 3-6  (336) larva L3 puffstage 7-9  (357) white prepupae new  (273) white prepupae 12hr  (450) white prepupae 24hr  (291) pupae 2d postWPP  130 pupae 3d postWPP  117 pupae 4d postWPP  (341) adult male 01day  135 adult male 05day  (171) adult male 30day  (145) adult female 01day  (1088) adult female 05day  (2312) adult female 30day  (2546) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6662) embryo 02-04hr  (9051) embryo 04-06hr  (5568) embryo 06-08hr  (3779) embryo 08-10hr  (3384) embryo 10-12hr  2470 embryo 12-14hr  1784 embryo 14-16hr  1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day  2312 adult female 30day  (2546) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6662 embryo 02-04hr    9051 embryo 04-06hr    5568 embryo 06-08hr    3779 embryo 08-10hr    3384 embryo 10-12hr    2470 embryo 12-14hr    1784 embryo 14-16hr    1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day    2312 adult female 30day    2546 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6662 embryo 02-04hr    9051 embryo 04-06hr    5568 embryo 06-08hr    3779 embryo 08-10hr    3384 embryo 10-12hr    2470 embryo 12-14hr    1784 embryo 14-16hr    1916 embryo 16-18hr    1398 embryo 18-20hr    820 embryo 20-22hr    1202 embryo 22-24hr    1166 larva L1    349 larva L2    365 larva L3 12hr old    322 larva L3 puffstage 1-2    294 larva L3 puffstage 3-6    336 larva L3 puffstage 7-9    357 white prepupae new    273 white prepupae 12hr    450 white prepupae 24hr    291 pupae 2d postWPP    130 pupae 3d postWPP    117 pupae 4d postWPP    341 adult male 01day    135 adult male 05day    171 adult male 30day    145 adult female 01day    1088 adult female 05day    2312 adult female 30day    2546 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035918    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035918 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035918 expression level Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035918 expression level Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    98.25 Larval Midgut    18 Larval Hindgut    31 Larval Malpighian Tubules    27.7 Larval Fat Body    33.8 Larval Salivary Gland    232.1 Larval Trachea    27.5 Larval Carcass    30.925 Adult Head    2.9 Adult Eye    0.6 Adult Brain    2.6 Adult Thoracic-Abdominal Ganglion    0.8 Adult Crop    9.8 Adult Midgut    9.4 Adult Hindgut    5.7 Adult Malpighian Tubules    4.1 Adult Fat Body    6.6 Adult Salivary Gland    4.2 Adult Heart    3 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    311 Adult Testis    6.5 Adult Male Accessory Gland    49.8 Adult Carcass    5.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2.9   NA  Eye    0.6   NA  Brain    2.6   98.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    0.8   NA  Crop    9.8   18  Midgut    9.4   31  Hindgut    5.7   27.7  Malpighian Tubules    4.1   33.8  Fat Body    6.6   232.1  Salivary Gland    4.2   NA  Heart    3   27.5  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    311   NA  Testis    6.5   NA  Male Accessory Gland    49.8   30.925  Carcass    5.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5971-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Cdc6 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Cdc6 Class Mutagen Stocks Known lesion Cdc6c04317 1 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cdc6 Class Mutagen Stocks Known lesion Cdc6dsRNA.1 in vitro construct - RNAi 0 Yes Cdc6dsRNA.2 in vitro construct - RNAi 0 Yes Cdc6dsRNA.cMa in vitro construct - RNAi 0 -- Cdc6GD4211 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Cdc6MtnA.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4211} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{PB}Cdc6c04317 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Crevel et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR003959 (FlyBase Curators et al., 2004-) DNA clamp loader activity inferred from sequence or structural similarity with Saccharomyces CDC6 (FlyBase, 1992-)
Biological Process
CV term Evidence References
pre-replicative complex assembly inferred from sequence or structural similarity with Saccharomyces CDC6 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
pre-replicative complex inferred from sequence or structural similarity with Saccharomyces CDC6 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cdc6 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64397 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035918 DroID - A comprehensive database of gene and protein interactions. • FBgn0035918 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38989
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10154 Dere\GG15067 Dgri\GH22514 Dmoj\GI12416 Dper\GL10294 Dpse\GA19269 Dsec\GM24924 Dsim\GD12971 Dvir\GJ12309 Dwil\GK17476 Dyak\GE21291
Curated drosophilid orthologs	Dame\Cdc6 (Wiggins and Malik, 2007) Dana\Cdc6 (Wiggins and Malik, 2007) Daur\Cdc6 (Wiggins and Malik, 2007) Dbai\Cdc6 (Wiggins and Malik, 2007) Dbar\Cdc6 (Wiggins and Malik, 2007) Dbia\Cdc6 (Wiggins and Malik, 2007) Dbii\Cdc6 (Wiggins and Malik, 2007) Dbip\Cdc6 (Wiggins and Malik, 2007) Dbir\Cdc6 (Wiggins and Malik, 2007) Dere\Cdc6 (Wiggins and Malik, 2007) Dfic\Cdc6 (Wiggins and Malik, 2007) Dkik\Cdc6 (Wiggins and Malik, 2007) Dluc\Cdc6 (Wiggins and Malik, 2007) Dlut\Cdc6 (Wiggins and Malik, 2007) Dmat\Cdc6 (Wiggins and Malik, 2007) Dmau\Cdc6 (Wiggins and Malik, 2007) Dmim\Cdc6 (Wiggins and Malik, 2007) Dmir\Cdc6 (Wiggins and Malik, 2007) Dmoj\Cdc6 (Wiggins and Malik, 2007) Dore\Cdc6 (Wiggins and Malik, 2007) Dpbp\Cdc6 (Wiggins and Malik, 2007) Dprl\Cdc6 (Wiggins and Malik, 2007) Dprs\Cdc6 (Wiggins and Malik, 2007) Dpse\GA19269 (Wiggins and Malik, 2007, ) Dpst\Cdc6 (Wiggins and Malik, 2007) Drua\Cdc6 (Wiggins and Malik, 2007) Dsec\Cdc6 (Wiggins and Malik, 2007) Dsim\Cdc6 (Wiggins and Malik, 2007) Dtak\Cdc6 (Wiggins and Malik, 2007) Dtei\Cdc6 (Wiggins and Malik, 2007) Dtre\Cdc6 (Wiggins and Malik, 2007) Dvir\Cdc6 (Wiggins and Malik, 2007) Dyak\Cdc6 (Wiggins and Malik, 2007)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010855-PA Aedes aegypti (mosquito) AGAP005176-PA Anopheles gambiae (mosquito) XP_625142.1 Apis mellifera (honey bee) XP_001947280.1 Acyrthosiphon pisum (pea aphid) At1g07270.1 Arabidopsis thaliana (wall cress) 22550 Batrachochytrium dendrobatidis (chytrid fungus) 123385 Branchiostoma floridae (lancelet) 123390 Branchiostoma floridae (lancelet) BGIBMGA006195-PA Bombyx mori (silk worm) ENSBTAP00000013706 Bos taurus (bovine) CAL0003555 Candida albicans (a form of yeast) CN22597 Caenorhabditis brenneri (small nematode) CBP30863 Caenorhabditis briggsae (nematode) CE08688 Caenorhabditis elegans (worm) ENSCAFP00000023734 Canis familiaris (dog) CAGL0K00605g Candida glabrata (haploid yeast) ENSCINP00000003393 Ciona intestinalis (sea squirt) JA01415 Caenorhabditis japonica (nematode) CPIJ005523 Culex pipens (mosquito) ENSCPOP00000009254 Cavia porcellus (guinea pig) RP35689 Caenorhabditis remanei (nematode) ENSCSAVP00000002981 Ciona savignyi (sedentary tunicate) 148720 Capitella spl (polychaete worm) 227580 Daphnia pulex (daphnia) ENSDARP00000008736 Danio rerio (zebra fish) ENSECAP00000007993 Equus caballus (horse) 63669 Hypsipyla robusta (cedar shoot borer) ENSP00000209728 Homo sapiens (human) ISCW006378-PA Ixodes scapularis (deer tick) KLLA0C03586g Kluyveromyces lactis (yeast) 138836 Lottia gigantea (owl limpet) 28402 Monocosta brevicollis (choanoflagellate) ENSMODP00000016403 Monodelphis domestica (gray opossum) ENSMMUP00000006322 Macaca mulatta (rhesus monkey) ENSMUSP00000091469 Mus musculus (house mouse) 80906 Nematostella vectensis (starlet anemone) XP_001605030.1 Nasonia vitripennis (wasp) ENSORLP00000000164 Oryzias latipes (japanese killifish) LOC_Os01g63710.1 Oryza sativa (asian rice) 16824 Ostreococcus tauri (green alga) PP24291 Pristionchus pacificus (nematode) 119899 Physcomitrella patens (moss) ENSPPYP00000009512 Pongo pygmaeus (orangutan) 79920 Phytophthora ramorum (sudden oak death pathogen) 139531 Phytophthora sojae (root rot pathogen) 172358 Populus trichocarpa (black cottonwood) ENSPTRP00000015543 Pan troglodytes (chimpanzee) ENSRNOP00000032177 Rattus norvegicus (norway rat) 5036937 Sorghum bicolor (sorghum) YJL194W Saccharomyces cerevisiae (budding yeast) Smp_145740 Schistosoma mansoni (trematode parasite) SPBC14C8.07c Schizosaccharomyces pombe (fission yeast) NP_999666.1 Strongylocentrotus purpuratus (purple sea urchin) 22362 Trichoplax adhaerens (metazoa) XP_001813224.1 Tribolium castaneum (red flour beetle) Tc00.1047053508119.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009057 Tetraodon nigroviridis (green spotted pufferfish) 8536 Thalassiosira pseudonana (marine diatom) ENSTRUP00000014204 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052749 Xenopus tropicalis (frog) YALI0C00671g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17743 NV11431 LH18014 ISCW006378 FBgn0238558 FBgn0219475 FBgn0199557 FBgn0184695 FBgn0179786 JGI_V11_255908 JGI_V11_227580 FBgn0079266 FBgn0147904 FBgn0135173 FBgn0129972 FBgn0107321 FBgn0087195 CPIJ005523 BGIBMGA006195 ACYPI005959 GB14936 AGAP005176 AAEL010855 PHUM395900 GLEAN_13003
Stocks & Reagents
Stocks Listed in FlyBase ( 1 )
Harvard	- PBac{PB}Cdc6c04317
Genomic Clones ( 1 )
	BACR06F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 50 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD25083
Other clones	DPiM_LD25083
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD10668 LD28088 LD30114 LD30156 LD32845 LD35307 LD37059 LD40072 LD41413 LD45631 LD46963 LP03118 RE04864 RE15585 RE18121 RE19283 RE21807 RE44078 RE44507 RE46132 RE46179 RE47289 RE48902 RE50802 RE52540 RE63867 RE63910 RE66829 SD07561
Other clones	109353 214501.69 274547 CK01.16A.F11 CK01.21D.F2 CK01.27A.G5 CK01.65C.G3 CK01.73B.B12 CK01.85D.D6 CK01.110A.C11 Dmel_dig_002527_0640_0299 EK023527 EK046809 EK053326 EK057830 EK067847 EK083410 EK099410 EK165831
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38989
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Cdc6 CG5971 (Crevel et al., 2005, Wiggins and Malik, 2007)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_139990 RefSeq (Proteins) • NP_648247 DDBJ / EMBL / GenBank • AA941117 AAF50387 AAK93146 AW942717 AY051722 Entrez Gene - A searchable database of RefSeq genes. • 38989 UniProtKB/TrEMBL • Q9VSM9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) CDC6, C-terminal (IPR015163) Cell division protein Cdc6 (IPR016314) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64397 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0035918 DroID - A comprehensive database of gene and protein interactions. • FBgn0035918 DRSC - Results from RNAi screens. • FBgn0035918 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035918 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5971-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035918 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38989 InParanoid A subset of ortholog calls from InParanoid. • AAEL010855-PA Aedes aegypti (mosquito) AGAP005176-PA Anopheles gambiae (mosquito) XP_625142.1 Apis mellifera (honey bee) XP_001947280.1 Acyrthosiphon pisum (pea aphid) At1g07270.1 Arabidopsis thaliana (wall cress) 22550 Batrachochytrium dendrobatidis (chytrid fungus) 123385 Branchiostoma floridae (lancelet) 123390 Branchiostoma floridae (lancelet) BGIBMGA006195-PA Bombyx mori (silk worm) ENSBTAP00000013706 Bos taurus (bovine) CAL0003555 Candida albicans (a form of yeast) CN22597 Caenorhabditis brenneri (small nematode) CBP30863 Caenorhabditis briggsae (nematode) CE08688 Caenorhabditis elegans (worm) ENSCAFP00000023734 Canis familiaris (dog) CAGL0K00605g Candida glabrata (haploid yeast) ENSCINP00000003393 Ciona intestinalis (sea squirt) JA01415 Caenorhabditis japonica (nematode) CPIJ005523 Culex pipens (mosquito) ENSCPOP00000009254 Cavia porcellus (guinea pig) RP35689 Caenorhabditis remanei (nematode) ENSCSAVP00000002981 Ciona savignyi (sedentary tunicate) 148720 Capitella spl (polychaete worm) 227580 Daphnia pulex (daphnia) ENSDARP00000008736 Danio rerio (zebra fish) ENSECAP00000007993 Equus caballus (horse) 63669 Hypsipyla robusta (cedar shoot borer) ENSP00000209728 Homo sapiens (human) ISCW006378-PA Ixodes scapularis (deer tick) KLLA0C03586g Kluyveromyces lactis (yeast) 138836 Lottia gigantea (owl limpet) 28402 Monocosta brevicollis (choanoflagellate) ENSMODP00000016403 Monodelphis domestica (gray opossum) ENSMMUP00000006322 Macaca mulatta (rhesus monkey) ENSMUSP00000091469 Mus musculus (house mouse) 80906 Nematostella vectensis (starlet anemone) XP_001605030.1 Nasonia vitripennis (wasp) ENSORLP00000000164 Oryzias latipes (japanese killifish) LOC_Os01g63710.1 Oryza sativa (asian rice) 16824 Ostreococcus tauri (green alga) PP24291 Pristionchus pacificus (nematode) 119899 Physcomitrella patens (moss) ENSPPYP00000009512 Pongo pygmaeus (orangutan) 79920 Phytophthora ramorum (sudden oak death pathogen) 139531 Phytophthora sojae (root rot pathogen) 172358 Populus trichocarpa (black cottonwood) ENSPTRP00000015543 Pan troglodytes (chimpanzee) ENSRNOP00000032177 Rattus norvegicus (norway rat) 5036937 Sorghum bicolor (sorghum) YJL194W Saccharomyces cerevisiae (budding yeast) Smp_145740 Schistosoma mansoni (trematode parasite) SPBC14C8.07c Schizosaccharomyces pombe (fission yeast) NP_999666.1 Strongylocentrotus purpuratus (purple sea urchin) 22362 Trichoplax adhaerens (metazoa) XP_001813224.1 Tribolium castaneum (red flour beetle) Tc00.1047053508119.150 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009057 Tetraodon nigroviridis (green spotted pufferfish) 8536 Thalassiosira pseudonana (marine diatom) ENSTRUP00000014204 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052749 Xenopus tropicalis (frog) YALI0C00671g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/cdc6.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38989 modMine - Data generated by the modENCODE project. • FBgn0035918 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17743 NV11431 LH18014 ISCW006378 FBgn0238558 FBgn0219475 FBgn0199557 FBgn0184695 FBgn0179786 JGI_V11_255908 JGI_V11_227580 FBgn0079266 FBgn0147904 FBgn0135173 FBgn0129972 FBgn0107321 FBgn0087195 CPIJ005523 BGIBMGA006195 ACYPI005959 GB14936 AGAP005176 AAEL010855 PHUM395900 GLEAN_13003
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Cdc6 (Wiggins and Malik, 2007) CG5971 (Crevel et al., 2005, Wiggins and Malik, 2007, Ma et al., 2006, Baeg et al., 2007, Greene et al., 2005) DmCdc6 (Crevel et al., 2005)
Name Synonym	Cdc6   CG5971
Secondary FlyBase IDs
References ( 14 )
Research paper	Wiggins and Malik, 2007, Fly 1(3): 155--163 Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins. [FBrf0200148] Ma et al., 2006, Nature 443(7109): 359--363 Prevalence of off-target effects in Drosophila RNA interference screens. [FBrf0194302] Crevel et al., 2005, J. Cell Sci. 118(11): 2451--2459 The Drosophila Cdc6/18 protein has functions in both early and late S phase in S2 cells. [FBrf0187826] Greene et al., 2005, Hum. Molec. Genet. 14(6): 799--811 Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis. [FBrf0184023] De Gregorio et al., 2001, Proc. Natl. Acad. Sci. USA 98(22): 12590--12595 Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays. [FBrf0139795]
Supplementary material	Dietzl et al., 2007, Nature 448(7150): Supplementary Table 1. [FBrf0202579] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231]
Erratum	Baeg et al., 2007, Genes Dev. 21(7): 875--877 Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. [FBrf0201371]
Personal communication to FlyBase	FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]