FB2021_01, released Feb 18, 2021

Gene: Dmel\Pex7

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General Information
Symbol
Dmel\Pex7
Species
D. melanogaster
Name
Peroxin 7
Annotation Symbol
CG6486
Feature Type
protein_coding_gene
FlyBase ID
FBgn0035922
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:8,647,145..8,651,011 [+]
Recombination map

3-26

RefSeq locus
NT_037436 REGION:8647145..8651011
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (6 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables peroxisome matrix targeting signal-2 binding
inferred from biological aspect of ancestor with PANTHER:PTN000522958
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in peroxisome organization
inferred from sequence or structural similarity with HGNC:8860
(Faust et al., 2012)
involved_in protein import into peroxisome matrix
inferred from biological aspect of ancestor with PANTHER:PTN000522958
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Baron et al., 2016)
located_in peroxisome
inferred from direct assay
(Baron et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN000522958
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in peroxisomal matrix
inferred from biological aspect of ancestor with PANTHER:PTN000522958
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in peroxisome
inferred from sequence or structural similarity with HGNC:8860
(Faust et al., 2012)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
PEROXINS -
Peroxisomes are eukaryotic organelles critical for the metabolism of fatty acids, particularly very-long-chain fatty acids, and other metabolites. The peroxin genes encode proteins required for peroxisome biogenesis. (Adapted from FBrf0209624).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Pex7 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Pex7-RA
FBtr0076568
NM_139994
1443
339
Pex7-RB
FBtr0273328
NM_001144442
1391
339
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Pex7-PA
FBpp0076295
37.6
339
4.89
NP_648251
AAF50379
Pex7-PB
FBpp0271836
37.6
339
4.89
NP_001137914
ACL83269
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

339 aa isoforms: Pex7-PA, Pex7-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pex7 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Baron et al., 2016)
located_in peroxisome
inferred from direct assay
(Baron et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pex7 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Pex7
Transgenic constructs containing regulatory region of Pex7
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (2)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PEX7
14 of 15
Yes
Yes
Hsap\APAF1
1 of 15
No
No
0  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Pex7
12 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (1)
Rnor\Pex7
13 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\pex7
7 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\pex7
10 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (1)
Atha\PEX7
9 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PEX7
11 of 15
Yes
Yes
Scer\HAT2
1 of 15
No
No
Scer\RAD28
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\pex7
10 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190BFW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003764
Drosophila simulans
Dsim\GD14117
Drosophila sechellia
Dsec\GM25079
Drosophila erecta
Dere\GG14336
Drosophila yakuba
Dyak\GE20764
Drosophila ananassae
Dana\GF24344
Drosophila pseudoobscura pseudoobscura
Dpse\GA19630
Drosophila persimilis
Dper\GL10329
Drosophila willistoni
Dwil\GK16726
Drosophila virilis
Dvir\GJ13063
Drosophila mojavensis
Dmoj\GI12919
Drosophila grimshawi
Dgri\GH15320
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507MO )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022771
Glossina morsitans
Tsetse fly
Gmor\GMOY005667
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00132
Mayetiola destructor
Hessian fly
Mdes\Mdes012310
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003117
Anopheles darlingi
American malaria mosquito
Adar\ADAC006152
Anopheles gambiae
Malaria mosquito
Agam\AGAP006264
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012142
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014776
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W097X )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA010858
Bombyx mori
Silkmoth
Bmor\BGIBMGA010859
Danaus plexippus
Monarch butterfly
Dple\DPOGS211400-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008083
Tribolium castaneum
Red flour beetle
Tcas\TC011845
Rhodnius prolixus
Kissing bug
Rpro\RPRC003308
Cimex lectularius
Bed bug
Clec\CLEC007772
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI21836
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13333
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0947 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Isca\ISCW020958
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57129.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03640
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302810
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0C6L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Pex7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_027082gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024604
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000024086
Gallus gallus
Domestic chicken
Ggal\PEX7
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Caf1-55
1 of 10
l(2)09851
1 of 10
Wdr24
1 of 10
Wdr59
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
Pex7MI14471
model of  peroxisomal biogenesis disorder
CEA
(Di Cara et al., 2019)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
PEX7; peroxisomal biogenesis factor 7
14 of 15
601757
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Interactions Browser
Summary of Genetic Interactions
esyN Network Diagram
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
3L
Recombination map

3-26

Cytogenetic map
66D9-66D10
Sequence location
3L:8,647,145..8,651,011 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
66D9-66D10
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
Experimentally Determined Recombination Data
Location

3-26

(FlyBase, 2016)

3-20.5

(Comeron et al., 2012)
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (5)
Genomic Clones (15)
 

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (9)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: Pex7 CG6486

    (Mast et al., 2011)
    Source for database merge of
    Additional comments
    Other Comments

    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

    (Stroschein-Stevenson et al., 2006)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 34 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (6)
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (30)