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Gene Dmel\TrpA1

General Information
Symbol	Dmel\TrpA1	Species	D. melanogaster
Name	Transient receptor potential A1	Annotation symbol	CG5751
Feature type	protein_coding_gene	FlyBase ID	FBgn0035934
Gene Model Status	Current	Stock availability	16 publicly available
Also Known As	dTrpA1, dANKTM1, TRPA, dTRPA
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66E3-66E3	Sequence location	3L:8,887,504..8,897,890 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transient receptor potential A1 is referred to in FlyBase by the symbol Dmel\TrpA1 (CG5751, FBgn0035934). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium channel activity. There is experimental evidence that it is involved in the biological process: memory; cellular response to heat; response to heat; thermosensory behavior; circadian sleep/wake cycle; thermotaxis; mechanosensory behavior; detection of chemical stimulus involved in sensory perception of bitter taste. 29 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; AC thermosensory neuron. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Ion transport domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3L:8887504..8897890.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles TrpA1[MI07645]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66E3-66E3   Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TrpA1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Initial two exons previously annotated as final exons of one alternative transcript of CG5747 mfr. Species conservation data supporst the current gene structures.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TrpA1-RG FBtr0331823  NM_001274671   4163   1232 TrpA1-RH FBtr0331824  NM_001274672   4160   1231 TrpA1-RI FBtr0331825  NM_140006   3878   1197 TrpA1-RJ FBtr0331826  NM_001104084   3875   1196 TrpA1-RK FBtr0331827  NM_001274673   4052   1195
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TrpA1-PG   FBpp0304207   138.8   1232   7.67     NP_001261600   AGB94295 TrpA1-PH   FBpp0304208   139.1   1231   7.92     NP_001261601   AGB94296 TrpA1-PI   FBpp0304209   135.2   1197   7.84     NP_648263   AAF50356 TrpA1-PJ   FBpp0304210   135.4   1196   8.08     NP_001097554   ABW08500 TrpA1-PK   FBpp0304211   134.7   1195   7.68     NP_001261602   AGB94297
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ion transport domain (IPR005821) Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50356   AE014296 ABW08500   AE014296 AGB94295   AE014296 AGB94296   AE014296 AGB94297   AI063890   AY302598 AAP76197   EY198568
UniProtKB/Swiss-Prot	Q7Z020
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   AC thermosensory neuron   (Hamada et al., 2008) neuron | subset   (Hamada et al., 2008)
Additional Descriptive Data
	TrpA1 is expressed in two uncharacterised groups of cells in the adult brain: the lateral cells (LC) and ventral cells (VC). (Hamada et al., 2008)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    1 head, virgin 4-day female    1 head, virgin 20-day female    1 head, mated 1-day female    1 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    6 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    2 embryo 20-22hr    2 embryo 22-24hr    3 larva L1    2 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    1 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    1 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1  (34) CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    34 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    1 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_20 mE1_20_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035934 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5751-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW TrpA1GD2375 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 TrpA1GD2375 Other Phenotypes Allele behavior defective, with Scer\GAL4Appl.G1a, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS behavior defective, with Scer\GAL4Appl.G1a, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS behavior defective, with Scer\GAL4Cha.7.4, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS behavior defective, with Scer\GAL4Cha.7.4, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS behavior defective, with Scer\GAL4TrpA1.SH, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS behavior defective, with Scer\GAL4TrpA1.SH, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS behavior defective (with TrpA1ins.3') TrpA1ins.5' behavior defective (with TrpA1ins.3'), with Df(3L)ED4415 TrpA1ins.5' behavior defective (with TrpA1ins.5') TrpA1ins.3' behavior defective (with TrpA1ins.5'), with Df(3L)ED4415 TrpA1ins.3' behavior defective | heat sensitive, with Scer\GAL4l.Trh.PK TrpA1Scer\UAS.cKa behavior defective | male | heat sensitive, with Scer\GAL4npf.1 TrpA1Scer\UAS.cKa circadian behavior defective, with Scer\GAL4P2.4.Pdf TrpA1Scer\UAS.cKa circadian behavior defective | adult stage | heat sensitive, with Scer\GAL4dimm-929 TrpA1Scer\UAS.cKa circadian behavior defective | adult stage | heat sensitive, with Scer\GAL4P2.4.Pdf, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS circadian behavior defective | adult stage | heat sensitive, with Scer\GAL4P2.4.Pdf, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS circadian behavior defective | adult stage | male | heat sensitive, with Scer\GAL4dimm-929, Scer\GAL80Pdf.PS TrpA1Scer\UAS.cKa courtship behavior defective, with Scer\GAL4ppk23.2.6 TrpA1Scer\UAS.cKa courtship behavior defective | female | heat sensitive, with Scer\FLP1250, Scer\GAL4dsx.KI TrpA1Scer\UAS.cKa courtship behavior defective | heat sensitive, with Scer\GAL4Ddc.HL9 TrpA1Scer\UAS.cKa courtship behavior defective | heat sensitive, with Scer\GAL4ple.PF TrpA1Scer\UAS.cKa courtship behavior defective | male | heat sensitive, with Scer\GAL4dsx.Δ2 TrpA1Scer\UAS.cKa TrpA1Scer\UAS.cSa TrpA1Scer\UAS.T:Hsap\MYC courtship behavior defective | male | heat sensitive, with Scer\GAL4dsx-GAL4 TrpA1Scer\UAS.cKa courtship behavior defective | male | heat sensitive, with Scer\GAL4fru.P1.B TrpA1Scer\UAS.cKa courtship behavior defective | male | heat sensitive, with Scer\GAL4fru.P1.D TrpA1Scer\UAS.cKa courtship behavior defective | male | heat sensitive, with Scer\GAL4GMR71G01 TrpA1Scer\UAS.cKa courtship behavior defective | male | heat sensitive, with Scer\GAL4Tdc2.PC TrpA1Scer\UAS.cKa learning defective | male | heat sensitive, with Scer\GAL4Tdc2.PC TrpA1Scer\UAS.cKa locomotor behavior defective, with Scer\GAL4c346 TrpA1Scer\UAS.cKa locomotor behavior defective, with Scer\GAL4ple.PF TrpA1Scer\UAS.cKa locomotor behavior defective | heat sensitive, with Scer\GAL4ple.PF TrpA1Scer\UAS.cKa locomotor rhythm defective | heat sensitive, with Scer\GAL4upd-E132 TrpA1Scer\UAS.cKa mating behavior defective | female | heat sensitive, with Scer\FLP1250, Scer\GAL4dsx.KI TrpA1Scer\UAS.cKa mating defective, with Scer\GAL4Tdc2.PC TrpA1Scer\UAS.cKa mating defective | heat sensitive, with Scer\GAL4CrzR.3.5 TrpA1Scer\UAS.cKa mating defective | heat sensitive, with Scer\GAL4Trh.1.0 TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL45-HT1B.PA, Scer\GAL4c061, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL45-HT1B.PA, Scer\GAL80Mef2.PT, Scer\GAL80ple.PK TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4c061, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4c259, Scer\GAL80Mef2.PT, Scer\GAL80ple.PK TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4Ddc.HL9 TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4Ddc.PL TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4exba-krasavietz, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4IP3K2-NP2758 TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4Mz19, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4Mz840, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4NP0047, Scer\GAL80Mef2.PT, Scer\GAL80ple.PK TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4NP7187 TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4npf.1 TrpA1Scer\UAS.cKa neuroanatomy defective | heat sensitive, with Scer\GAL4futsch-C380 TrpA1Scer\UAS.cKa neuroanatomy defective | third instar larval stage, with Scer\GAL4GMR.PF TrpA1Scer\UAS.cKa neurophysiology defective | adult stage (with TrpA1ins.3') TrpA1ins.5' neurophysiology defective | adult stage (with TrpA1ins.5') TrpA1ins.3' neurophysiology defective | adult stage | heat sensitive, with Scer\GAL4Akap200-NP2222 TrpA1Scer\UAS.cKa neurophysiology defective | adult stage | heat sensitive, with Scer\GAL4elav-C155 TrpA1Scer\UAS.cKa neurophysiology defective | third instar larval stage | heat sensitive, with Scer\GAL4Akap200-NP2222 TrpA1Scer\UAS.cKa neurophysiology defective | third instar larval stage | heat sensitive, with Scer\GAL4elav-C155 TrpA1Scer\UAS.cKa pain response defective (with Df(3L)ED4415) TrpA1W903 pain response defective | larval stage TrpA1GD2375 TrpA1Scer\UAS.cKa pain response defective | larval stage | recessive TrpA1W903 paralytic | adult stage | heat sensitive, with Scer\GAL4repo TrpA1Scer\UAS.cKa paralytic | heat sensitive, with Scer\GAL4elav-C155 TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4n-syb.PS TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4ple.PF TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4ple.TH-D-4 TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4ple.TH-D' TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4ple.TH-D TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4ple.TH-G-1 TrpA1Scer\UAS.cKa sleep defective | heat sensitive, with Scer\GAL4Tdc2.PC TrpA1Scer\UAS.cKa smell perception defective, with Ecol\lexAGH146.T:Scer\GAL4-GAD TrpA1Ecol\lexAop.T:SV40\nls2 smell perception defective | heat sensitive, with Scer\GAL4GH146 TrpA1Scer\UAS.cKa smell perception defective | heat sensitive, with Scer\GAL4VPN TrpA1Scer\UAS.cKa song defective, with Scer\GAL4NP2361 TrpA1Scer\UAS.T:Hsap\MYC song defective | heat sensitive TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4NP2361 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4n-syb.PS TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT5534 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT17258 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT19579 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT40556 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT41688 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT43702 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT46099 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT57239 TrpA1Scer\UAS.cvPa starvation stress response defective, with Scer\GAL4Ast.2.1 TrpA1Scer\UAS.cKa tarsal response defective, with Scer\GAL4ple.PF TrpA1Scer\UAS.cKa taste perception defective (with TrpA1ins.3') TrpA1ins.5' taste perception defective (with TrpA1ins.5') TrpA1ins.3' taste perception defective | recessive TrpA11 TrpA1GAL4 thermotaxis behavior defective TrpA11 TrpA1dsRNA.2872-3605 thermotaxis behavior defective | larval stage TrpA11 thermotaxis behavior defective | larval stage, with Scer\GAL4ninaE.PT TrpA1JF01360 thermotaxis behavior defective | third instar larval stage TrpA11 visible, with Scer\GAL4pnr-MD237 TrpA1GD2375 Phenotype manifest in Allele AC thermosensory neuron (with TrpA1ins.3') TrpA1ins.5' AC thermosensory neuron (with TrpA1ins.5') TrpA1ins.3' dendrite | heat sensitive, with Scer\GAL4futsch-C380 TrpA1Scer\UAS.cKa dendrite | third instar larval stage, with Scer\GAL4GMR.PF TrpA1Scer\UAS.cKa indirect flight muscle motor neuron MN5 | heat sensitive, with Scer\GAL4futsch-C380 TrpA1Scer\UAS.cKa LNv neuron | third instar larval stage, with Scer\GAL4GMR.PF TrpA1Scer\UAS.cKa mesothoracic tergum, with Scer\GAL4pnr-MD237 TrpA1GD2375 neuromuscular junction | heat sensitive, with Scer\GAL4elav-C155 TrpA1Scer\UAS.cKa
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of TrpA1 Class Mutagen Stocks Known lesion TrpA11 recombination 9 -- TrpA1GAL4 ends-out gene targeting 0 Yes TrpA1ins.3' recombination ends-in gene targeting 0 Yes TrpA1ins.5' recombination ends-in gene targeting 0 Yes TrpA1MI07645 0 -- TrpA1W903 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TrpA1 Class Mutagen Stocks Known lesion TrpA1GD2375 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TrpA1Scer\UAS.cKa in vitro construct - regulatory fusion 2 Yes TrpA1JF01054 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TrpA1JF01360 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TrpA1JF02461 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TrpA1Scer\UAS.cKc in vitro construct - regulatory fusion 1 Yes TrpA1Scer\UAS.cKd in vitro construct - regulatory fusion 1 Yes TrpA1+t21 in vitro construct - genomic fragment 0 Yes TrpA1+tHa in vitro construct - genomic fragment 0 Yes TrpA1C.Scer\UAS in vitro construct - regulatory fusion 0 Yes TrpA1dsRNA.2872-3605 in vitro construct - RNAi 0 Yes TrpA1dsRNA.A.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TrpA1dsRNA.B.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TrpA1dsRNA.cRa in vitro construct - RNAi 0 Yes TrpA1Ecol\lexAop.T:SV40\nls2 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes TrpA1Scer\FRT.stop.Scer\UAS.cSa in vitro construct - regulatory fusion 0 Yes TrpA1Scer\FRT.stop.Scer\UAS.T:Disc\RFP-mCherry FLPase in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TrpA1Scer\FRT.stop.Scer\UAS.T:Hsap\MYC FLPase in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TrpA1Scer\FRT.stop.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TrpA1Scer\UAS.cKb in vitro construct - regulatory fusion 0 Yes TrpA1Scer\UAS.cSa FLPase 0 Yes TrpA1Scer\UAS.cvPa in vitro construct - regulatory fusion FLPase 0 Yes TrpA1Scer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion FLPase 0 Yes TrpA1Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion FLPase 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ED4415 (Zhong et al., 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2375} NA P{TRiP.JF01054} NA P{TRiP.JF01360} NA P{TRiP.JF02461} NA P{UAS(FRT.stop)TrpA1.S} NA P{UAS(FRT.stop)TrpA1} NA P{UAS(FRT.stop)TrpA1mCherry} NA P{UAS(FRT.stop)TrpA1myc} NA P{UAS(-FRT)TrpA1.P} NA P{UAS(-FRT)TrpA1.S} NA P{UAS(-FRT)TrpA1mCherry} NA P{UAS(-FRT)TrpA1myc} NA P{UAS-TrpA1.C} NA P{UAS-TrpA1.K} NA P{UAS-TrpA1.RC} NA P{UAS-TrpA1.RD} NA P{UAS-TrpA1.RNAi.A} NA P{UAS-TrpA1.RNAi.B} NA GAL4 construct P{TrpA1-GAL4.C-D} No P{TrpA1-GAL4.R} No P{TrpA1-GAL4.SH} No PBac{TrpA1-GAL4.P} No characterization construct M{LexAop-TrpA1} NA P{TrpA1+t21} NA P{TrpA1+tHa} NA P{TrpA1-QF.P} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}TrpA1MI07645 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
NOT bitter taste receptor activity inferred from direct assay (Kim et al., 2010)
Biological Process
CV term Evidence References
cellular response to heat inferred from direct assay (Hamada et al., 2008) circadian sleep/wake cycle inferred from mutant phenotype (Parisky et al., 2008) detection of chemical stimulus involved in sensory perception of bitter taste inferred from mutant phenotype (Kim et al., 2010) mechanosensory behavior inferred from mutant phenotype (Zhong et al., 2012) memory inferred from mutant phenotype (Krashes et al., 2009) response to heat inferred from mutant phenotype (Hamada et al., 2008) thermosensory behavior inferred from mutant phenotype (Zhong et al., 2012) thermotaxis inferred from direct assay (Kwon et al., 2008) inferred from mutant phenotype (Rosenzweig et al., 2005, Shen et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
calcium channel activity inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ion channel activity inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
calcium ion transport inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ion transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-) response to temperature stimulus non-traceable author statement (Viswanath et al., 2003) transmembrane transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TrpA1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0035934 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7Z020
Orthologs
OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG65MNQM Dipteran inclusive ortholog search EOG6XKVFX Insect inclusive ortholog search EOG66HF5J Arthropod inclusive ortholog search EOG6WWQ09 Metazoa inclusive ortholog search EOG67HJGN
Orthologs in Drosophila Species (EOG65MNQM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\TrpA1     Drosophila simulans   Dsim\GD12958 Y   Drosophila sechellia   Dsec\GM24910 Y   Drosophila erecta   Dere\GG15054 Y   Drosophila yakuba   Dyak\GE21276 Y   Drosophila ananassae   Dana\GF10143 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA28660 Y   Drosophila persimilis   Dper\GL10275 Y   Drosophila willistoni   Dwil\GK17464 Y   Drosophila virilis   Dvir\GJ12294 Y   Drosophila mojavensis   Dmoj\TrpA1 Y   Drosophila grimshawi   Dgri\GH16134 Y
Orthologs in non-Drosophila Dipterans (EOG6XKVFX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001268   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009419   Anopheles gambiae Malaria mosquito  Agam\AGAP004863   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002323   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002324
Orthologs in non-Dipteran Insects (EOG66HF5J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acyrthosiphon pisum Pea aphid  Apim\ACYPI006397   Bombyx mori Silkmoth  Bmor\BGIBMGA002131   Pediculus humanus Human body louse  Phum\PHUM581070   Tribolium castaneum Red flour beetle  Tcas\TRPA1
Orthologs in non-Insect Arthropods (EOG6WWQ09)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\NOG   Daphnia pulex Water flea  Dpux\rbcL   Daphnia pulex Water flea  Dpux\JGI_V11_333611   Daphnia pulex Water flea  Dpux\JGI_V11_17024   Daphnia pulex Water flea  Dpux\JGI_V11_5038   Daphnia pulex Water flea  Dpux\JGI_V11_6634   Daphnia pulex Water flea  Dpux\MT-CYB   Daphnia pulex Water flea  Dpux\JGI_V11_36579   Daphnia pulex Water flea  Dpux\JGI_V11_6638   Daphnia pulex Water flea  Dpux\JGI_V11_17028   Daphnia pulex Water flea  Dpux\ASMT   Ixodes scapularis Deer tick  Isca\ISCW011428
Orthologs in non-Arthropod Metazoa (EOG67HJGN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018832gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012224gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013983gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017113gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010822gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_021013gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025566gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009748gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010817gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017114gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015403gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005421gn   Danio rerio Zebrafish  Drer\trpa1a   Xenopus tropicalis Western clawed frog  Xtro\trpa1   Gallus gallus Domestic chicken  Ggal\TRPA1   Mus musculus House mouse  Mmus\Trpa1   Rattus norvegicus Norway rat  Rnor\Trpa1   Homo sapiens Human  Hsap\ENSG00000104321
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000104321
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12958 Drosophila sechellia Dsec\GM24910 Drosophila erecta Dere\GG15054 Drosophila yakuba Dyak\GE21276 Drosophila ananassae Dana\GF10143 Drosophila pseudoobscura pseudoobscura Dpse\GA28660 Drosophila persimilis Dper\GL10275 Drosophila willistoni Dwil\GK17464 Drosophila virilis Dvir\GJ12294 Drosophila mojavensis Dmoj\TrpA1 Drosophila grimshawi Dgri\GH16134
Stocks & Reagents
Stocks Listed in FlyBase ( 16 )
Bloomington	36342 TrpA11 26504 w1118; TrpA11 26263 w*; P{UAS-TrpA1.K}attP16 31384 y1 v1; P{TRiP.JF01360}attP2 31504 y1 v1; P{TRiP.JF01054}attP2 36780 y1 v1; P{TRiP.JF02461}attP2 36922 w*; TrpA11, P{TrpA1-GAL4.R}3 36925 w*; TrpA11 P{UAS-TrpA1.RC}attP2 36927 w*; TrpA11 P{UAS-TrpA1.RD}attP2 26264 w*; P{UAS-TrpA1.K}attP2/TM6B, Tb1
VDRC	v37249 w1118; P{GD2375}v37249 v37250 w1118; P{GD2375}v37250/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR10P09 BACR18D24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03996
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035934 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39015
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TrpA1 Anktm1 (Garrity et al., 2005.2.23)
Source for database merge of
Additional comments
Other Comments
	TrpA1 functions as a molecular sensor of warmth. (Hamada et al., 2008) TrpA1 is required for normal thermotactic behaviour. (Rosenzweig et al., 2005) Larvae injected with dsRNA against TrpA1 show abnormal thermotactic behaviour, while their chemotactic response to n-octyl acetate and response to being touched with a hot (55oC) probe is normal. (Rosenzweig et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140006 NM_001104084 NM_001274671 NM_001274672 NM_001274673 RefSeq (Proteins) • NP_648263 NP_001097554 NP_001261600 NP_001261601 NP_001261602 DDBJ / EMBL / GenBank • AAF50356 AAP76197 ABW08500 AGB94295 AGB94296 AGB94297 AY302598 Entrez Gene - A searchable database of RefSeq genes. • 39015 UniProtKB/Swiss-Prot • Q7Z020
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ion transport domain (IPR005821) Ankyrin repeat (IPR002110) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0035934 DRSC - Results from RNAi screens. • FBgn0035934 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035934 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5751-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035934 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39015 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/anktm1-dtrpa1.htm modMine - Data generated by the modENCODE project. • FBgn0035934 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q7Z020
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	ANKTM1 (Goodman, 2003) Anktm1   CG5751 (Roos et al., 2005, Ni et al., 2011.7.19, Ni et al., 2008, Tsubouchi et al., 2012) CG5761 (Padinjat and Andrews, 2004) CT18073 (Littleton and Ganetzky, 2000) dANKTM1 (Lee et al., 2005, Viswanath et al., 2003, Viswanath, 2003.5.19, Tobin and Bargmann, 2004, Padinjat and Andrews, 2004) DmTRPA1 (Kohno et al., 2010) dTRPA (Sénatore et al., 2010) dTrpA (Yuan et al., 2011) dTrpA1 (Zhong et al., 2012, Rosenzweig et al., 2005, Rosenzweig et al., 2005, Pan et al., 2012, Parisky et al., 2008, Melom and Littleton, 2013, Pan et al., 2011, Carrillo et al., 2010, Hamada et al., 2008, Pulver et al., 2009, Krashes et al., 2009, Hong et al., 2006, Alekseyenko et al., 2010, Keene et al., 2010, Luo and Sehgal, 2012, Certel et al., 2010, Cognigni et al., 2011, Liu et al., 2012, Aso et al., 2012) dTRPA1 (Caterina and Montell, 2005, Garrity et al., 2005.2.23, Shohat-Ophir et al., 2012, Diangelo et al., 2011, Tayler et al., 2012, Hong et al., 2006, Gallio et al., 2011, Inagaki et al., 2012) dtrpA1 (Rosenzweig et al., 2008) TRPA (Lumpkin, 2007, Xu et al., 2010) TrpA (Chen et al., 2010, Zhou et al., 2012) TRPA1 (Garrity et al., 2005.2.23, Tayler et al., 2012, Hergarden et al., 2012, Kwon et al., 2008, Kim et al., 2010, Matsuura et al., 2009, Kang et al., 2012, Sudhakaran et al., 2012) TrpA1 (Garrity, 2008.12.9, Bolukbasi et al., 2012, Rezaval et al., 2012, Shang et al., 2011, Donlea et al., 2011, Lu et al., 2012, Kwon et al., 2008, Kang et al., 2010, Alekseyenko et al., 2010, von Philipsborn et al., 2011, Tsubouchi et al., 2012, Xiang et al., 2010, Kadowaki, 2011.10.7, Kadowaki, 2011.10.7, Vonhoff et al., 2013, Majumdar et al., 2012, Thistle et al., 2012, Plaçais et al., 2012, Kong et al., 2010, Keleman et al., 2012) trpA1 (Kwon et al., 2008, Kwon et al., 2010, Shen et al., 2011, Petersen and Stowers, 2011)
Name Synonym	Transient receptor potential A1 (Garrity et al., 2005.2.23, Kang et al., 2010, Tsubouchi et al., 2012) transient-receptor-potential A1 (Yuan et al., 2011) Transient receptor potential cation channel (Donlea et al., 2011)
Secondary FlyBase IDs
References ( 89 )
Generate a list of	All references relating to this gene ( 89 )
List References by type	Research paper  ( 66 ) Supplementary material  ( 5 ) Review  ( 5 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 38 )
	Melom and Littleton, 2013, J. Neurosci. 33(3): 1169--1178 Mutation of a NCKX Eliminates Glial Microdomain Calcium Oscillations and Enhances Seizure Susceptibility. [FBrf0220564] Tang et al., 2013, J. Neurosci. 33(3): 894--901 Temperature Integration at the AC Thermosensory Neurons in Drosophila. [FBrf0220550] Vonhoff et al., 2013, Development 140(3): 606--616 Temporal coherency between receptor expression, neural activity and AP-1-dependent transcription regulates Drosophila motoneuron dendrite development. [FBrf0220342] Wang et al., 2013, J. Physiol. 591(1): 185--201 Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli. [FBrf0220363] Aso et al., 2012, PLoS Genet. 8(7): e1002768 Three dopamine pathways induce aversive odor memories with different stability. [FBrf0218860] Bolukbasi et al., 2012, Open Biol. 2(1): 110031 Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling. [FBrf0218466] Hergarden et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(10): 3967--3972 Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. [FBrf0217661] Inagaki et al., 2012, Cell 148(3): 583--595 Visualizing Neuromodulation In Vivo: TANGO-Mapping of Dopamine Signaling Reveals Appetite Control of Sugar Sensing. [FBrf0217362] Kang et al., 2012, Nature 481(7379): 76--80 Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila. [FBrf0217153] Keleman et al., 2012, Nature 489(7414): 145--149 Dopamine neurons modulate pheromone responses in Drosophila courtship learning. [FBrf0219398] Liu et al., 2012, Curr. Biol. 22(22): 2114--2123 Two dopaminergic neurons signal to the dorsal fan-shaped body to promote wakefulness in Drosophila. [FBrf0220041] Lu et al., 2012, PLoS Genet. 8(3): e1002587 ppk23-Dependent Chemosensory Functions Contribute to Courtship Behavior in Drosophila melanogaster. [FBrf0217844] Luo and Sehgal, 2012, Cell 148(4): 765--779 Regulation of Circadian Behavioral Output via a MicroRNA-JAK/STAT Circuit. [FBrf0217497] Majumdar et al., 2012, Cell 148(3): 515--529 Critical Role of Amyloid-like Oligomers of Drosophila Orb2 in the Persistence of Memory. [FBrf0217407] Pan et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(25): 10065--10070 Joint control of Drosophila male courtship behavior by motion cues and activation of male-specific P1 neurons. [FBrf0218611] Plaçais et al., 2012, Nat. Neurosci. 15(4): 592--599 Slow oscillations in two pairs of dopaminergic neurons gate long-term memory formation in Drosophila. [FBrf0217853] Rezaval et al., 2012, Curr. Biol. 22(13): 1155--1165 Neural circuitry underlying Drosophila female postmating behavioral responses. [FBrf0218941] Shohat-Ophir et al., 2012, Science 335(6074): 1351--1355 Sexual deprivation increases ethanol intake in Drosophila. [FBrf0217810] Sudhakaran et al., 2012, J. Neurosci. 32(21): 7225--7231 Plasticity of recurrent inhibition in the Drosophila antennal lobe. [FBrf0218409] Tayler et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(50): 20697--20702 A neuropeptide circuit that coordinates sperm transfer and copulation duration in Drosophila. [FBrf0220217] Thistle et al., 2012, Cell 149(5): 1140--1151 Contact Chemoreceptors Mediate Male-Male Repulsion and Male-Female Attraction during Drosophila Courtship. [FBrf0218411] Ueno et al., 2012, Nat. Neurosci. 15(11): 1516--1523 Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. [FBrf0219823] Zhong et al., 2012, Cell Rep. 1(1): 43--55 Thermosensory and non-thermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat sensor domains of a thermoTRP channel. [FBrf0217493] Zhou et al., 2012, J. Neurosci. 32(41): 14281--14287 Molecular Genetic Analysis of Sexual Rejection: Roles of Octopamine and Its Receptor OAMB in Drosophila Courtship Conditioning. [FBrf0219612] Babcock et al., 2011, Curr. Biol. 21(18): 1525--1533 Hedgehog signaling regulates nociceptive sensitization. [FBrf0216292] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Diangelo et al., 2011, PLoS ONE 6(5): e19921 The central clock neurons regulate lipid storage in Drosophila. [FBrf0213791] Donlea et al., 2011, Science 332(6037): 1571--1576 Inducing sleep by remote control facilitates memory consolidation in Drosophila. [FBrf0214001] Gallio et al., 2011, Cell 144(4): 614--624 The coding of temperature in the Drosophila brain. [FBrf0213085] Kohatsu et al., 2011, Neuron 69(3): 498--508 Female Contact Activates Male-Specific Interneurons that Trigger Stereotypic Courtship Behavior in Drosophila. [FBrf0213024] Neely et al., 2011, PLoS ONE 6(8): e24343 TrpA1 Regulates Thermal Nociception in Drosophila. [FBrf0215215] Pan et al., 2011, PLoS ONE 6(6): e21144 Turning Males On: Activation of Male Courtship Behavior in Drosophila melanogaster. [FBrf0214254] Petersen and Stowers, 2011, PLoS ONE 6(9): e24531 A Gateway MultiSite Recombination Cloning Toolkit. [FBrf0215584] Shang et al., 2011, Nat. Neurosci. 14(7): 889--895 Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine. [FBrf0214816] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Shih and Chiang, 2011, J. Neurogenet. 25(1-2): 1--6 Anatomical Characterization of Thermosensory AC Neurons in the Adult Drosophila Brain. [FBrf0213700] von Philipsborn et al., 2011, Neuron 69(3): 509--522 Neuronal control of Drosophila courtship song. [FBrf0212984] Yuan et al., 2011, Science 333(6048): 1458--1462 Light-induced structural and functional plasticity in Drosophila larval visual system. [FBrf0215276] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...