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Gene Dmel\TrpA1

General Information
Symbol	Dmel\TrpA1	Species	D. melanogaster
Name	Transient receptor potential A1	Annotation symbol	CG5751
Feature type	protein_coding_gene	FlyBase ID	FBgn0035934
Gene Model Status	Current	Stock availability	15 publicly available
Also Known As	dTrpA1, dANKTM1, TRPA
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66E3-66E3	Sequence location	3L:8,887,788..8,896,780 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transient receptor potential A1 is referred to in FlyBase by the symbol Dmel\TrpA1 (CG5751, FBgn0035934). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium channel activity. There is experimental evidence that it is involved in the biological process: memory; cellular response to heat; response to heat; circadian sleep/wake cycle; thermotaxis; detection of chemical stimulus involved in sensory perception of bitter taste. 22 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; AC thermosensory neuron. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Ankyrin repeat; Ankyrin repeat-containing domain; Ion transport. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Gene sequence location is 3L:8887788..8896780.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Transgenic Constructs P{UAS-TrpA1.RC} P{UAS-TrpA1.RD} Sequence features BKN22635 HFA10544 Alleles TrpA1[Scer\UAS.cKd] TrpA1[Scer\UAS.cKc] References Xiang et al., 2010, Nature 468(7326): 921--926 Kadowaki, 2011.10.7, Kadowaki insertions. Kohatsu et al., 2011, Neuron 69(3): 498--508 Kadowaki, 2011.10.7, Kadowaki constructs and insertions. Kohno et al., 2010, J. Neurosci. 30(37): 12219--12229 Neely et al., 2011, PLoS ONE 6(8): e24343
FB2011_10	Transgenic Constructs P{TrpA1-QF.P} References Petersen and Stowers, 2011, PLoS ONE 6(9): e24531 Matsuura et al., 2009, BMC Evol. Biol. 9: 228 Babcock et al., 2011, Curr. Biol. 21(18): 1525--1533 Controlled Vocabulary Terms AC thermosensory neuron neuron subset adult stage
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66E3-66E3   Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TrpA1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Initial two exons previously annotated as final exons of one alternative transcript of CG5747 mfr. Species conservation data supporst the current gene structures.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TrpA1-RE FBtr0300208  NM_140006   3891   1296 TrpA1-RF FBtr0300209  NM_001104084   3888   1295
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TrpA1-PE   FBpp0289445   146.0   1296   7.81     NP_648263   AAF50356 TrpA1-PF   FBpp0289446   146.3   1295   8.04     NP_001097554   ABW08500
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Ion transport (IPR005821) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50356   AE014296 ABW08500   AI063890   AY302598 AAP76197   EY198568
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7Z020
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   AC thermosensory neuron   (Hamada et al., 2008) neuron | subset   (Hamada et al., 2008)
Additional Descriptive Data
	TrpA1 is expressed in two uncharacterised groups of cells in the adult brain: the lateral cells (LC) and ventral cells (VC). (Hamada et al., 2008)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035934    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035934 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035934 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr  (152) embryo 18-20hr  (197) embryo 20-22hr  (166) embryo 22-24hr  (197) larva L1  (157) larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2  (119) larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day  103 adult female 01day  (111) adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035934 expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr  (152) embryo 18-20hr  (197) embryo 20-22hr  (166) embryo 22-24hr  (197) larva L1  (157) larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2  119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day  103 adult female 01day  111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    2 embryo 04-06hr    8 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    3 embryo 12-14hr    5 embryo 14-16hr    57 embryo 16-18hr    152 embryo 18-20hr    197 embryo 20-22hr    166 embryo 22-24hr    197 larva L1    157 larva L2    84 larva L3 12hr old    71 larva L3 puffstage 1-2    119 larva L3 puffstage 3-6    79 larva L3 puffstage 7-9    56 white prepupae new    26 white prepupae 12hr    36 white prepupae 24hr    40 pupae 2d postWPP    47 pupae 3d postWPP    41 pupae 4d postWPP    52 adult male 01day    87 adult male 05day    96 adult male 30day    103 adult female 01day    111 adult female 05day    77 adult female 30day    51 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035934    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035934 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_20
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035934 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5751-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 TrpA1GD2375 Other Phenotypes Allele behavior defective, with Scer\GAL4Appl.G1a, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS behavior defective, with Scer\GAL4Appl.G1a, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS behavior defective, with Scer\GAL4Cha.7.4, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS behavior defective, with Scer\GAL4Cha.7.4, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS behavior defective, with Scer\GAL4TrpA1.SH, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS behavior defective, with Scer\GAL4TrpA1.SH, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS behavior defective (with TrpA1ins.3') TrpA1ins.5' behavior defective (with TrpA1ins.3'), with Df(3L)ED4415 TrpA1ins.5' behavior defective (with TrpA1ins.5') TrpA1ins.3' behavior defective (with TrpA1ins.5'), with Df(3L)ED4415 TrpA1ins.3' behavior defective | heat sensitive, with Scer\GAL4l.Trh.PK TrpA1Scer\UAS.cKa circadian behavior defective, with Scer\GAL4P2.4.Pdf TrpA1Scer\UAS.cKa circadian behavior defective | adult stage | heat sensitive, with Scer\GAL4dimm-929 TrpA1Scer\UAS.cKa circadian behavior defective | adult stage | heat sensitive, with Scer\GAL4P2.4.Pdf, TrpA1dsRNA.A.Scer\UAS TrpA1dsRNA.B.Scer\UAS circadian behavior defective | adult stage | heat sensitive, with Scer\GAL4P2.4.Pdf, TrpA1dsRNA.B.Scer\UAS TrpA1dsRNA.A.Scer\UAS circadian behavior defective | adult stage | male | heat sensitive, with Scer\GAL4dimm-929, Scer\GAL80Pdf.PS TrpA1Scer\UAS.cKa mating defective, with Scer\GAL4Tdc2.PC TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4c061, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4exba-krasavietz, Scer\GAL80Mef2.PT TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4IP3K2-NP2758 TrpA1Scer\UAS.cKa memory defective | heat sensitive, with Scer\GAL4npf.1 TrpA1Scer\UAS.cKa neurophysiology defective | adult stage (with TrpA1ins.3') TrpA1ins.5' neurophysiology defective | adult stage (with TrpA1ins.5') TrpA1ins.3' paralytic | heat sensitive, with Scer\GAL4elav-C155 TrpA1Scer\UAS.cKa song defective, with Scer\GAL4NP2361 TrpA1Scer\UAS.T:Hsap\MYC song defective | heat sensitive, with Scer\GAL4fru-GAL4 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4NP2361 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4n-syb.PS TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT5534 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT17258 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT19579 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT40556 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT41688 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT43702 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT46099 TrpA1Scer\UAS.cvPa song defective | heat sensitive, with Scer\GAL4VT57239 TrpA1Scer\UAS.cvPa taste perception defective (with TrpA1ins.3') TrpA1ins.5' taste perception defective (with TrpA1ins.5') TrpA1ins.3' taste perception defective | recessive TrpA11 TrpA1GAL4 thermotaxis behavior defective TrpA11 TrpA1dsRNA.2872-3605 thermotaxis behavior defective | larval stage TrpA11 thermotaxis behavior defective | larval stage, with Scer\GAL4ninaE.PT TrpA1JF01360 thermotaxis behavior defective | third instar larval stage TrpA11 visible, with Scer\GAL4pnr-MD237 TrpA1GD2375 Phenotype manifest in Allele AC thermosensory neuron (with TrpA1ins.3') TrpA1ins.5' AC thermosensory neuron (with TrpA1ins.5') TrpA1ins.3' mesothoracic tergum, with Scer\GAL4pnr-MD237 TrpA1GD2375 neuromuscular junction | heat sensitive, with Scer\GAL4elav-C155 TrpA1Scer\UAS.cKa
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of TrpA1 Class Mutagen Stocks Known lesion TrpA11 recombination 9 -- TrpA1GAL4 ends-out gene targeting 0 Yes TrpA1ins.3' recombination 0 Yes TrpA1ins.5' recombination 0 Yes
Alleles Carried on Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TrpA1 Class Mutagen Stocks Known lesion TrpA1GD2375 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TrpA1Scer\UAS.cKa in vitro construct - regulatory fusion 2 Yes TrpA1JF01054 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TrpA1JF01360 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TrpA1+tHa in vitro construct - genomic fragment 0 Yes TrpA1dsRNA.2872-3605 in vitro construct - RNAi 0 Yes TrpA1dsRNA.A.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TrpA1dsRNA.B.Scer\UAS in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TrpA1dsRNA.cRa in vitro construct - RNAi 0 Yes TrpA1Scer\FRT.stop.Scer\UAS.T:Disc\RFP-mCherry FLPase in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TrpA1Scer\FRT.stop.Scer\UAS.T:Hsap\MYC FLPase in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TrpA1Scer\FRT.stop.Scer\UAS in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes TrpA1Scer\UAS.cKb in vitro construct - regulatory fusion 0 Yes TrpA1Scer\UAS.cKc in vitro construct - regulatory fusion 0 Yes TrpA1Scer\UAS.cKd in vitro construct - regulatory fusion 0 Yes TrpA1Scer\UAS.cvPa in vitro construct - regulatory fusion FLPase 0 Yes TrpA1Scer\UAS.T:Disc\RFP-mCherry in vitro construct - regulatory fusion in vitro construct - coding region fusion FLPase 0 Yes TrpA1Scer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion FLPase 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2375} NA P{TRiP.JF01054} NA P{TRiP.JF01360} NA P{UAS(FRT.stop)TrpA1} NA P{UAS(FRT.stop)TrpA1mCherry} NA P{UAS(FRT.stop)TrpA1myc} NA P{UAS(-FRT)TrpA1.P} NA P{UAS(-FRT)TrpA1mCherry} NA P{UAS(-FRT)TrpA1myc} NA P{UAS-TrpA1.K} NA P{UAS-TrpA1.RC} NA P{UAS-TrpA1.RD} NA P{UAS-TrpA1.RNAi.A} NA P{UAS-TrpA1.RNAi.B} NA characterization construct P{TrpA1+tHa} NA P{TrpA1-QF.P} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
NOT bitter taste receptor activity inferred from direct assay (Kim et al., 2010)
Biological Process
CV term Evidence References
cellular response to heat inferred from direct assay (Hamada et al., 2008) circadian sleep/wake cycle inferred from mutant phenotype (Parisky et al., 2008) detection of chemical stimulus involved in sensory perception of bitter taste inferred from mutant phenotype (Kim et al., 2010) memory inferred from mutant phenotype (Krashes et al., 2009) response to heat inferred from mutant phenotype (Hamada et al., 2008) thermotaxis inferred from direct assay (Kwon et al., 2008) inferred from mutant phenotype (Rosenzweig et al., 2005, Shen et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
calcium channel activity inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ion channel activity inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
calcium ion transport inferred from sequence or structural similarity (Littleton and Ganetzky, 2000) ion transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-) response to temperature stimulus non-traceable author statement (Viswanath et al., 2003) transmembrane transport inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR005821 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TrpA1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0035934
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10143 Dere\GG15054 Dgri\GH16134 Dmoj\TrpA1 Dper\GL10275 Dpse\GA28660 Dsec\GM24910 Dsim\GD12958 Dvir\GJ12294 Dwil\GK17464 Dyak\GE21276
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009419-PA Aedes aegypti (mosquito) AGAP004863-PA Anopheles gambiae (mosquito) XP_001944501.1 Acyrthosiphon pisum (pea aphid) At4g03440.1 Arabidopsis thaliana (wall cress) BGIBMGA002131-PA Bombyx mori (silk worm) ENSBTAP00000002668 Bos taurus (bovine) CBP29927 Caenorhabditis briggsae (nematode) CE42588 Caenorhabditis elegans (worm) ENSCAFP00000011746 Canis familiaris (dog) ENSCINP00000022485 Ciona intestinalis (sea squirt) JA13419 Caenorhabditis japonica (nematode) CPIJ002324 Culex pipens (mosquito) ENSCPOP00000010361 Cavia porcellus (guinea pig) RP34539 Caenorhabditis remanei (nematode) ENSCSAVP00000001776 Ciona savignyi (sedentary tunicate) 226671 Capitella spl (polychaete worm) ENSDARP00000044284 Danio rerio (zebra fish) ENSECAP00000000205 Equus caballus (horse) ENSGACP00000003662 Gymnopilus aculeatus (mushroom) ENSGALP00000025157 Gallus gallus (chicken) GL50803_114671 Giardia lamblia (flagellated protozoan) 159882 Hypsipyla robusta (cedar shoot borer) ENSP00000262209 Homo sapiens (human) ISCW011428-PA Ixodes scapularis (deer tick) 229171 Lottia gigantea (owl limpet) ENSMODP00000008943 Monodelphis domestica (gray opossum) ENSMMUP00000014078 Macaca mulatta (rhesus monkey) ENSMUSP00000043594 Mus musculus (house mouse) 81127 Nematostella vectensis (starlet anemone) ENSOANP00000021331 Ornithorynchus anatinus (platypus) ENSORLP00000010069 Oryzias latipes (japanese killifish) LOC_Os09g15370.1 Oryza sativa (asian rice) PHUM000501-PA Pediculus humanus (human body louse) ENSPPYP00000020939 Pongo pygmaeus (orangutan) 571737 Populus trichocarpa (black cottonwood) ENSPTRP00000046657 Pan troglodytes (chimpanzee) ENSRNOP00000009874 Rattus norvegicus (norway rat) Smp_125690 Schistosoma mansoni (trematode parasite) XP_001186461.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000011013 Tetraodon nigroviridis (green spotted pufferfish) 24328 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031495 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000034881 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW011428 FBgn0238544 FBgn0219463 FBgn0199543 FBgn0184682 FBgn0179772 FBgn0250020 JGI_V11_6634 JGI_V11_257448 JGI_V11_1835 JGI_V11_34645 JGI_V11_63811 JGI_V11_6638 JGI_V11_5038 JGI_V11_333611 JGI_V11_36579 FBgn0147884 FBgn0147885 FBgn0135161 FBgn0123605 FBgn0107308 FBgn0087184 CPIJ002324 CPIJ002323 BGIBMGA002131 ACYPI006397 AGAP004863 AAEL009419 AAEL001268 PHUM581070 GLEAN_02449
Stocks & Reagents
Stocks Listed in FlyBase ( 15 )
Bloomington	36342 TrpA11 26504 w1118; TrpA11 26263 w*; P{UAS-TrpA1.K}attP16 31384 y1 v1; P{TRiP.JF01360}attP2 31504 y1 v1; P{TRiP.JF01054}attP2 36922 w*; TrpA11, P{TrpA1-GAL4.R}3 36925 w*; TrpA11 P{UAS-TrpA1.RC}attP2 36927 w*; TrpA11 P{UAS-TrpA1.RD}attP2 26264 w*; P{UAS-TrpA1.K}attP2/TM6B, Tb1 36926 w*; TrpA11 P{UAS-DmojTRPA1.S}attP2
VDRC	v37249 w1118; P{GD2375}v37249 v37250 w1118; P{GD2375}v37250/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR10P09 BACR18D24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 1 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03996
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035934 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39015
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TrpA1 Anktm1 (Garrity et al., 2005.2.23)
Source for database merge of
Additional comments
Other Comments
	TrpA1 functions as a molecular sensor of warmth. (Hamada et al., 2008) TrpA1 is required for normal thermotactic behaviour. (Rosenzweig et al., 2005) Larvae injected with dsRNA against TrpA1 show abnormal thermotactic behaviour, while their chemotactic response to n-octyl acetate and response to being touched with a hot (55oC) probe is normal. (Rosenzweig et al., 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140006 NM_001104084 RefSeq (Proteins) • NP_648263 NP_001097554 DDBJ / EMBL / GenBank • AAF50356 AAP76197 ABW08500 AY302598 Entrez Gene - A searchable database of RefSeq genes. • 39015 UniProtKB/TrEMBL • Q7Z020
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Ion transport (IPR005821) Ankyrin repeat-containing domain (IPR020683)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0035934 DRSC - Results from RNAi screens. • FBgn0035934 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035934 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5751-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035934 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39015 InParanoid A subset of ortholog calls from InParanoid. • AAEL009419-PA Aedes aegypti (mosquito) AGAP004863-PA Anopheles gambiae (mosquito) XP_001944501.1 Acyrthosiphon pisum (pea aphid) At4g03440.1 Arabidopsis thaliana (wall cress) BGIBMGA002131-PA Bombyx mori (silk worm) ENSBTAP00000002668 Bos taurus (bovine) CBP29927 Caenorhabditis briggsae (nematode) CE42588 Caenorhabditis elegans (worm) ENSCAFP00000011746 Canis familiaris (dog) ENSCINP00000022485 Ciona intestinalis (sea squirt) JA13419 Caenorhabditis japonica (nematode) CPIJ002324 Culex pipens (mosquito) ENSCPOP00000010361 Cavia porcellus (guinea pig) RP34539 Caenorhabditis remanei (nematode) ENSCSAVP00000001776 Ciona savignyi (sedentary tunicate) 226671 Capitella spl (polychaete worm) ENSDARP00000044284 Danio rerio (zebra fish) ENSECAP00000000205 Equus caballus (horse) ENSGACP00000003662 Gymnopilus aculeatus (mushroom) ENSGALP00000025157 Gallus gallus (chicken) GL50803_114671 Giardia lamblia (flagellated protozoan) 159882 Hypsipyla robusta (cedar shoot borer) ENSP00000262209 Homo sapiens (human) ISCW011428-PA Ixodes scapularis (deer tick) 229171 Lottia gigantea (owl limpet) ENSMODP00000008943 Monodelphis domestica (gray opossum) ENSMMUP00000014078 Macaca mulatta (rhesus monkey) ENSMUSP00000043594 Mus musculus (house mouse) 81127 Nematostella vectensis (starlet anemone) ENSOANP00000021331 Ornithorynchus anatinus (platypus) ENSORLP00000010069 Oryzias latipes (japanese killifish) LOC_Os09g15370.1 Oryza sativa (asian rice) PHUM000501-PA Pediculus humanus (human body louse) ENSPPYP00000020939 Pongo pygmaeus (orangutan) 571737 Populus trichocarpa (black cottonwood) ENSPTRP00000046657 Pan troglodytes (chimpanzee) ENSRNOP00000009874 Rattus norvegicus (norway rat) Smp_125690 Schistosoma mansoni (trematode parasite) XP_001186461.1 Strongylocentrotus purpuratus (purple sea urchin) ENSTNIP00000011013 Tetraodon nigroviridis (green spotted pufferfish) 24328 Thalassiosira pseudonana (marine diatom) ENSTRUP00000031495 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000034881 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/anktm1-dtrpa1.htm modMine - Data generated by the modENCODE project. • FBgn0035934 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW011428 FBgn0238544 FBgn0219463 FBgn0199543 FBgn0184682 FBgn0179772 FBgn0250020 JGI_V11_6634 JGI_V11_257448 JGI_V11_1835 JGI_V11_34645 JGI_V11_63811 JGI_V11_6638 JGI_V11_5038 JGI_V11_333611 JGI_V11_36579 FBgn0147884 FBgn0147885 FBgn0135161 FBgn0123605 FBgn0107308 FBgn0087184 CPIJ002324 CPIJ002323 BGIBMGA002131 ACYPI006397 AGAP004863 AAEL009419 AAEL001268 PHUM581070 GLEAN_02449
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	ANKTM1 (Goodman, 2003) Anktm1   CG5751 (Roos et al., 2005, Ni et al., 2008) CG5761 (Padinjat and Andrews, 2004) CT18073 (Littleton and Ganetzky, 2000) dANKTM1 (Lee et al., 2005, Viswanath et al., 2003, Viswanath, 2003.5.19, Tobin and Bargmann, 2004, Padinjat and Andrews, 2004) DmTRPA1 (Kohno et al., 2010) dTRPA (Sénatore et al., 2010) dTrpA1 (Rosenzweig et al., 2005, Rosenzweig et al., 2005, Parisky et al., 2008, Hamada et al., 2008, Pulver et al., 2009, Krashes et al., 2009, Hong et al., 2006, Alekseyenko et al., 2010, Keene et al., 2010, Certel et al., 2010, Cognigni et al., 2011) dTRPA1 (Caterina and Montell, 2005, Garrity et al., 2005.2.23, Diangelo et al., 2011, Hong et al., 2006, Gallio et al., 2011) dtrpA1 (Rosenzweig et al., 2008) TRPA (Lumpkin, 2007, Xu et al., 2010) TrpA (Chen et al., 2010) TRPA1 (Garrity et al., 2005.2.23, Kwon et al., 2008, Kim et al., 2010, Matsuura et al., 2009) TrpA1 (Garrity, 2008.12.9, Kwon et al., 2008, Kang et al., 2010, Alekseyenko et al., 2010, von Philipsborn et al., 2011, Xiang et al., 2010, Kadowaki, 2011.10.7, Kadowaki, 2011.10.7) trpA1 (Kwon et al., 2008, Kwon et al., 2010, Shen et al., 2011, Petersen and Stowers, 2011)
Name Synonym	Transient receptor potential A1 (Garrity et al., 2005.2.23, Kang et al., 2010)
Secondary FlyBase IDs
References ( 54 )
Generate a list of	All references relating to this gene ( 54 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 2 ) Review  ( 5 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 22 )
	Babcock et al., 2011, Curr. Biol. 21(18): 1525--1533 Hedgehog signaling regulates nociceptive sensitization. [FBrf0216292] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Diangelo et al., 2011, PLoS ONE 6(5): e19921 The central clock neurons regulate lipid storage in Drosophila. [FBrf0213791] Gallio et al., 2011, Cell 144(4): 614--624 The coding of temperature in the Drosophila brain. [FBrf0213085] Kohatsu et al., 2011, Neuron 69(3): 498--508 Female Contact Activates Male-Specific Interneurons that Trigger Stereotypic Courtship Behavior in Drosophila. [FBrf0213024] Neely et al., 2011, PLoS ONE 6(8): e24343 TrpA1 Regulates Thermal Nociception in Drosophila. [FBrf0215215] Petersen and Stowers, 2011, PLoS ONE 6(9): e24531 A Gateway MultiSite Recombination Cloning Toolkit. [FBrf0215584] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Shih and Chiang, 2011, J. Neurogenet. 25(1-2): 1--6 Anatomical Characterization of Thermosensory AC Neurons in the Adult Drosophila Brain. [FBrf0213700] von Philipsborn et al., 2011, Neuron 69(3): 509--522 Neuronal control of Drosophila courtship song. [FBrf0212984] Alekseyenko et al., 2010, PLoS ONE 5(5): e10806 Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster. [FBrf0210961] Certel et al., 2010, PLoS ONE 5(10): e13248 Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. [FBrf0212145] Chen et al., 2010, J. Neurosci. 30(18): 6247--6252 The amiloride-sensitive epithelial Na+ channel PPK28 is essential for drosophila gustatory water reception. [FBrf0210746] Kang et al., 2010, Nature 464(7288): 597--600 Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. [FBrf0210403] Keene et al., 2010, Curr. Biol. 20(13): 1209--1215 Clock and cycle Limit Starvation-Induced Sleep Loss in Drosophila. [FBrf0211239] Kim et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(18): 8440--8445 Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. [FBrf0210738] Kohno et al., 2010, J. Neurosci. 30(37): 12219--12229 Honey bee thermal/chemical sensor, AmHsTRPA, reveals neofunctionalization and loss of transient receptor potential channel genes. [FBrf0216546] Kwon et al., 2010, J. Neurosci. 30(31): 10465--10471 Fine Thermotactic Discrimination between the Optimal and Slightly Cooler Temperatures via a TRPV Channel in Chordotonal Neurons. [FBrf0211446] Kwon et al., 2010, Curr. Biol. 20(18): 1672--1678 Drosophila TRPA1 Channel Is Required to Avoid the Naturally Occurring Insect Repellent Citronellal. [FBrf0211878] Sénatore et al., 2010, PLoS Genet. 6(9): e1001088 Response to Mechanical Stress Is Mediated by the TRPA Channel Painless in the Drosophila Heart. [FBrf0211762] Xiang et al., 2010, Nature 468(7326): 921--926 Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. [FBrf0212615] Xu et al., 2010, J. Neurosci. 30(7): 2504--2512 A g-protein-coupled neuropeptide y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila. [FBrf0210034] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...