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Gene Dmel\CG4452

General Information
Symbol	Dmel\CG4452	Species	D. melanogaster
Name		Annotation symbol	CG4452
Feature type	protein_coding_gene	FlyBase ID	FBgn0035981
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67B2-67B2	Sequence location	3L:9,360,484..9,363,400 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG4452 (FBgn0035981). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637940_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG4452. Gene sequence location is 3L:9360484..9363400.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA10422 BKN22073
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67B2-67B2   Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG4452 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Multiphase exon postulated: reading frame of first coding exons differ in alternative transcripts.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG4452-RA FBtr0089493  NM_140046   1663   390 CG4452-RB FBtr0089494  NM_168328   1576   320 CG4452-RC FBtr0089495  NM_168329   1460   320
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG4452-PA   FBpp0088493   42.8   390   9.78     NP_648303   AAF50294 CG4452-PB   FBpp0088494   35.4   320   10.28     NP_729473   AAF50295 CG4452-PC   FBpp0088495   35.4   320   10.28     NP_729474   AAN11960
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441449   AA696900   AA735639   AA736156   AA820995   AA941578   AA941687   AA950329   AE014296 AAF50294   AE014296 AAF50295   AE014296 AAN11960   AI258192   AI456942   AI511870   AI513071   AI515338   AI515343   AI515885   AI543856   AI544136   AW942604   AX260156   AY069481 AAL39626   BF494014   BF494902   BF496247   BF496916   BF497019   BF501108   BG638002   BG639013   BH614876   BH614877   BI229607   BI230922   BI351988   BI372438   BI372479   BI563916   BI585499   BI639839   BT001452 AAN71207   BT044495   BT126074   CO273629   CO297022   CO302348   EC064381   EC085516   EC209370   EC223157   EC248194   GH941778   GH942943   GH943354   GH943367   GH944679   GH944992   GH945100   GH945170   GH945686   GH946729   GH946899   GH947636   GH947708   GH949304   GH949323   GH949742   GH952354   GH953245   GH953899   GH954482   GH954522   GH955854   GH955887   GH956123   GH956413   GH956742   GH957788   GH958256   GH959568   GH960379   GH960973   GH961968   GH962842   GH963289   GH963304   GH963426   GH963442   GH964105   GH964721   GH964862   GH965521   GH965583   GH965820   GH965968   GH966129   GH966143   GH966712   GH966971   GH967130   GH967167   GH967275   GH967707   GH967796   GH968350   GH969227   GH969629   GH969850   GH970759   GH971681   GH972304   GH973057   GH973388   GH973530   GH973732   GH974071   GH975268   GH975307   GH976182   GH976319   GH977038   GH978526   GH978551   GH982040   GH982643   GH983849   GH984460   GH984922   GH985054
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IH34 Q9VSW6 Q9VSW7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0035981    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0035981 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0035981 expression level Developmental Stage   Expression Level embryo 00-02hr    5044 embryo 02-04hr    9904 embryo 04-06hr    9663 embryo 06-08hr    6693 embryo 08-10hr    5169 embryo 10-12hr    3783 embryo 12-14hr    2713 embryo 14-16hr    2127 embryo 16-18hr    1939 embryo 18-20hr    1992 embryo 20-22hr    2844 embryo 22-24hr    2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2    2001 larva L3 puffstage 3-6    3410 larva L3 puffstage 7-9    3497 white prepupae new    2882 white prepupae 12hr    2118 white prepupae 24hr    2249 pupae 2d postWPP    1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day    1584 adult male 05day    2327 adult male 30day    1622 adult female 01day    1894 adult female 05day    3104 adult female 30day    2995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5044) embryo 02-04hr  (9904) embryo 04-06hr  (9663) embryo 06-08hr  (6693) embryo 08-10hr  (5169) embryo 10-12hr  (3783) embryo 12-14hr  (2713) embryo 14-16hr  (2127) embryo 16-18hr  (1939) embryo 18-20hr  (1992) embryo 20-22hr  (2844) embryo 22-24hr  (2409) larva L1  (764) larva L2  (839) larva L3 12hr old  (644) larva L3 puffstage 1-2  (2001) larva L3 puffstage 3-6  (3410) larva L3 puffstage 7-9  (3497) white prepupae new  (2882) white prepupae 12hr  (2118) white prepupae 24hr  (2249) pupae 2d postWPP  (1616) pupae 3d postWPP  (956) pupae 4d postWPP  (1006) adult male 01day  (1584) adult male 05day  (2327) adult male 30day  (1622) adult female 01day  (1894) adult female 05day  (3104) adult female 30day  (2995) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5044) embryo 02-04hr  (9904) embryo 04-06hr  (9663) embryo 06-08hr  (6693) embryo 08-10hr  (5169) embryo 10-12hr  (3783) embryo 12-14hr  (2713) embryo 14-16hr  (2127) embryo 16-18hr  (1939) embryo 18-20hr  (1992) embryo 20-22hr  (2844) embryo 22-24hr  (2409) larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2  (2001) larva L3 puffstage 3-6  (3410) larva L3 puffstage 7-9  (3497) white prepupae new  (2882) white prepupae 12hr  (2118) white prepupae 24hr  (2249) pupae 2d postWPP  (1616) pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day  (1584) adult male 05day  (2327) adult male 30day  (1622) adult female 01day  (1894) adult female 05day  (3104) adult female 30day  (2995) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5044 embryo 02-04hr    9904 embryo 04-06hr    9663 embryo 06-08hr    6693 embryo 08-10hr    5169 embryo 10-12hr    3783 embryo 12-14hr    2713 embryo 14-16hr    2127 embryo 16-18hr    1939 embryo 18-20hr    1992 embryo 20-22hr    2844 embryo 22-24hr    2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2    2001 larva L3 puffstage 3-6    3410 larva L3 puffstage 7-9    3497 white prepupae new    2882 white prepupae 12hr    2118 white prepupae 24hr    2249 pupae 2d postWPP    1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day    1584 adult male 05day    2327 adult male 30day    1622 adult female 01day    1894 adult female 05day    3104 adult female 30day    2995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5044 embryo 02-04hr    9904 embryo 04-06hr    9663 embryo 06-08hr    6693 embryo 08-10hr    5169 embryo 10-12hr    3783 embryo 12-14hr    2713 embryo 14-16hr    2127 embryo 16-18hr    1939 embryo 18-20hr    1992 embryo 20-22hr    2844 embryo 22-24hr    2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2    2001 larva L3 puffstage 3-6    3410 larva L3 puffstage 7-9    3497 white prepupae new    2882 white prepupae 12hr    2118 white prepupae 24hr    2249 pupae 2d postWPP    1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day    1584 adult male 05day    2327 adult male 30day    1622 adult female 01day    1894 adult female 05day    3104 adult female 30day    2995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0035981 expression level Developmental Stage   Expression Level embryo 00-02hr    5044 embryo 02-04hr    9904 embryo 04-06hr    9663 embryo 06-08hr    6693 embryo 08-10hr    5169 embryo 10-12hr    3783 embryo 12-14hr    2713 embryo 14-16hr    2127 embryo 16-18hr    1939 embryo 18-20hr    1992 embryo 20-22hr    2844 embryo 22-24hr    2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2    2001 larva L3 puffstage 3-6    3410 larva L3 puffstage 7-9    3497 white prepupae new    2882 white prepupae 12hr    2118 white prepupae 24hr    2249 pupae 2d postWPP    1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day    1584 adult male 05day    2327 adult male 30day    1622 adult female 01day    1894 adult female 05day    3104 adult female 30day    2995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5044) embryo 02-04hr  (9904) embryo 04-06hr  (9663) embryo 06-08hr  (6693) embryo 08-10hr  (5169) embryo 10-12hr  (3783) embryo 12-14hr  (2713) embryo 14-16hr  (2127) embryo 16-18hr  (1939) embryo 18-20hr  (1992) embryo 20-22hr  (2844) embryo 22-24hr  (2409) larva L1  (764) larva L2  (839) larva L3 12hr old  (644) larva L3 puffstage 1-2  (2001) larva L3 puffstage 3-6  (3410) larva L3 puffstage 7-9  (3497) white prepupae new  (2882) white prepupae 12hr  (2118) white prepupae 24hr  (2249) pupae 2d postWPP  (1616) pupae 3d postWPP  (956) pupae 4d postWPP  (1006) adult male 01day  (1584) adult male 05day  (2327) adult male 30day  (1622) adult female 01day  (1894) adult female 05day  (3104) adult female 30day  (2995) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5044) embryo 02-04hr  (9904) embryo 04-06hr  (9663) embryo 06-08hr  (6693) embryo 08-10hr  (5169) embryo 10-12hr  (3783) embryo 12-14hr  (2713) embryo 14-16hr  2127 embryo 16-18hr  1939 embryo 18-20hr  1992 embryo 20-22hr  (2844) embryo 22-24hr  2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2  2001 larva L3 puffstage 3-6  (3410) larva L3 puffstage 7-9  (3497) white prepupae new  (2882) white prepupae 12hr  2118 white prepupae 24hr  2249 pupae 2d postWPP  1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day  1584 adult male 05day  2327 adult male 30day  1622 adult female 01day  1894 adult female 05day  (3104) adult female 30day  (2995) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5044 embryo 02-04hr    9904 embryo 04-06hr    9663 embryo 06-08hr    6693 embryo 08-10hr    5169 embryo 10-12hr    3783 embryo 12-14hr    2713 embryo 14-16hr    2127 embryo 16-18hr    1939 embryo 18-20hr    1992 embryo 20-22hr    2844 embryo 22-24hr    2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2    2001 larva L3 puffstage 3-6    3410 larva L3 puffstage 7-9    3497 white prepupae new    2882 white prepupae 12hr    2118 white prepupae 24hr    2249 pupae 2d postWPP    1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day    1584 adult male 05day    2327 adult male 30day    1622 adult female 01day    1894 adult female 05day    3104 adult female 30day    2995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5044 embryo 02-04hr    9904 embryo 04-06hr    9663 embryo 06-08hr    6693 embryo 08-10hr    5169 embryo 10-12hr    3783 embryo 12-14hr    2713 embryo 14-16hr    2127 embryo 16-18hr    1939 embryo 18-20hr    1992 embryo 20-22hr    2844 embryo 22-24hr    2409 larva L1    764 larva L2    839 larva L3 12hr old    644 larva L3 puffstage 1-2    2001 larva L3 puffstage 3-6    3410 larva L3 puffstage 7-9    3497 white prepupae new    2882 white prepupae 12hr    2118 white prepupae 24hr    2249 pupae 2d postWPP    1616 pupae 3d postWPP    956 pupae 4d postWPP    1006 adult male 01day    1584 adult male 05day    2327 adult male 30day    1622 adult female 01day    1894 adult female 05day    3104 adult female 30day    2995 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0035981    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0035981 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0035981 expression level Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules    771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules  (771) Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules    771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules    771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0035981 expression level Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules    771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules  771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules    771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    345.3 Larval Midgut no informative data Larval Hindgut    272.8 Larval Malpighian Tubules    771 Larval Fat Body    271.3 Larval Salivary Gland    353.1 Larval Trachea    224.85 Larval Carcass    363.9 Adult Head    191.1 Adult Eye    115.575 Adult Brain    239.9 Adult Thoracic-Abdominal Ganglion    198.2 Adult Crop    457.7 Adult Midgut    255 Adult Hindgut    309.8 Adult Malpighian Tubules    284.1 Adult Fat Body    295.5 Adult Salivary Gland    360.8 Adult Heart    156.35 Adult VirginFemale Spermatheca    476.4 Adult InseminatedFemale Spermatheca    466.4 Adult Ovary    363.8 Adult Testis    158.8 Adult Male Accessory Gland    261.6 Adult Carcass    253.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    191.1   NA  Eye    115.575   NA  Brain    239.9   345.3  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    198.2   NA  Crop    457.7   no informative data  Midgut    255   272.8  Hindgut    309.8   771  Malpighian Tubules    284.1   271.3  Fat Body    295.5   353.1  Salivary Gland    360.8   NA  Heart    156.35   224.85  Trachea    NA   NA  VirginFemale Spermatheca    476.4   NA  InseminatedFemale Spermatheca    466.4   NA  Ovary    363.8   NA  Testis    158.8   NA  Male Accessory Gland    261.6   363.9  Carcass    253.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035981 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4452-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG4452c01056 viable, with Scer\GAL4pnr-MD237 CG4452GD11321 Sterility Allele fertile CG4452c01056 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG4452 Class Mutagen Stocks Known lesion CG4452c01056 piggyBac transposase 1 -- CG4452KG02739 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG4452 Class Mutagen Stocks Known lesion CG4452GD11321 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG4452KK102007 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11321} NA P{KK102007} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}CG4452KG02739 NA PBac{PB}CG4452c01056 NA insertion of mobile activating element P{EP}EP3583-16 NA P{EP}EP3583-17 NA
Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG4452 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0035981
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10687 Dere\GG15365 Dgri\GH14584 Dmoj\GI13909 Dper\GL22439 Dpse\GA18194 Dsec\GM25138 Dsim\GD14172 Dvir\GJ11767 Dwil\GK17632 Dyak\GE20828
Curated drosophilid orthologs	Dpse\GA18194
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009606-PA Aedes aegypti (mosquito) XP_391846.2 Apis mellifera (honey bee) XP_001945837.1 Acyrthosiphon pisum (pea aphid) 122985 Branchiostoma floridae (lancelet) XP_001894317.1 Brugia malayi (roundworm nematode) ENSBTAP00000026131 Bos taurus (bovine) CN09358 Caenorhabditis brenneri (small nematode) CN26721 Caenorhabditis brenneri (small nematode) CBP09268 Caenorhabditis briggsae (nematode) CE18015 Caenorhabditis elegans (worm) ENSCAFP00000006105 Canis familiaris (dog) Chro.20355 Cryptosporidium hominis (obligate parasite) JA09645 Caenorhabditis japonica (nematode) cgd2_3380 Cryptosporidium parvum (protozoan parasite) CPIJ009258 Culex pipens (mosquito) ENSCPOP00000005578 Cavia porcellus (guinea pig) RP18235 Caenorhabditis remanei (nematode) RP22127 Caenorhabditis remanei (nematode) 166048 Capitella spl (polychaete worm) 302396 Daphnia pulex (daphnia) ENSDARP00000026447 Danio rerio (zebra fish) ENSECAP00000004239 Equus caballus (horse) ENSGACP00000026934 Gymnopilus aculeatus (mushroom) ENSGALP00000027754 Gallus gallus (chicken) 71540 Hypsipyla robusta (cedar shoot borer) ENSP00000351631 Homo sapiens (human) 217061 Lottia gigantea (owl limpet) ENSMODP00000032072 Monodelphis domestica (gray opossum) ENSMMUP00000019417 Macaca mulatta (rhesus monkey) ENSMUSP00000030696 Mus musculus (house mouse) 232079 Nematostella vectensis (starlet anemone) ENSOANP00000015248 Ornithorynchus anatinus (platypus) ENSORLP00000010628 Oryzias latipes (japanese killifish) PHUM004654-PA Pediculus humanus (human body louse) PP04586 Pristionchus pacificus (nematode) ENSPPYP00000004334 Pongo pygmaeus (orangutan) ENSPTRP00000039139 Pan troglodytes (chimpanzee) ENSRNOP00000053036 Rattus norvegicus (norway rat) Smp_164990 Schistosoma mansoni (trematode parasite) XP_001182954.1 Strongylocentrotus purpuratus (purple sea urchin) XP_970598.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014743 Tetraodon nigroviridis (green spotted pufferfish) TP01_0643 Theileria parva (parasitic protozoan) ENSTRUP00000039810 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015410 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16951 NV25612 LH13688 ISCW005242 FBgn0238120 FBgn0219631 FBgn0199021 FBgn0185859 FBgn0179999 JGI_V11_302396 FBgn0078201 FBgn0160031 FBgn0136663 FBgn0122060 FBgn0107617 FBgn0087728 CPIJ009259 CPIJ009258 ACYPI010058 GB14829 AGAP005928 AAEL009606 PHUM607040 GLEAN_14630
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	10360 w1118; PBac{PB}CG4452c01056 Fdxhc01056 13228 y1 w67c23; P{SUPor-P}CG4452KG02739 ry506
VDRC	v107773 P{KK102007}VIE-260B v40526 w1118; P{GD11321}v40526 v40525 w1118; P{GD11321}v40525/TM3
Genomic Clones ( 1 )
	BACR01E20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 120 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM12283 LD21662 RH36108
Other clones	FI03822
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02417 AT03675 AT10006 AT11066 AT16334 GM08673 GM17130 LD11867 LD16389 LD24962 LD25780 LD27044 LD28852 LD37119 LD43419 LD45296 LD45518 LD46375 LD47111 LD47119 LP01327 RE16190 RE27425 RE59393 RE59451 RH25091 RH34662 SD22533
Other clones	11225 55815 57866 82181 102399 AT10924 EK111653 EK183951 EK215745 LD41580 RP004038693 RP004050114 RP004073584 RP004079054 RP004084456 RP004088954 RP004090185 RP004113340 RP004113920 RP004122372 RP004132623 RP004145379 RP004183106 RP004187408 RP004188911 RP004197710 RP004204783 RP004205550 RP004206263 RP004215504 RP004217452 RP004218549 RP004225443 RP004228198 RP004232838 RP004234997 RP004237078 RP004238659 RP004252546 RP004252769 RP004253618 RP004257187 RP004257787 RP004259159 RP004262414 RP004303864 RP004322898 RP004324687 RP004345565 RP004346911 RP004369902 RP004377238 RP004380076 RP004382997 RP004387268 RP004399776 RP004408755 RP004423105 RP004434585 RP004438352 RP004444557 RP004456312 RP004463190 RP004463856 RP004469727 RP004471143 RP004471673 RP004473687 RP004477065 RP004482661 RP004483392 RP004484689 RP004487281 RP004491174 RP004491363 RP004498779 RP004501230 RP004508180 RP004508316 RP004514430 RP004514676 RP004515949 RP004516365 RP004520629 RP004529197 RP004540252 RP004545903 RP004556703
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0035981 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39069
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG4452 anon-WO0172774.118 (FlyBase, 1996-)
Additional comments	Source for merge of CG4452 anon-WO0172774.118 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene. (Hansen et al., 2009)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140046 NM_168328 NM_168329 RefSeq (Proteins) • NP_648303 NP_729473 NP_729474 DDBJ / EMBL / GenBank • AA735639 AA736156 AAF50294 AAF50295 AAL39626 AAN11960 AAN71207 AW942604 AX260156 AY069481 BF494014 BF494902 BF496247 BF497019 BF501108 BH614876 BH614877 BI351988 BT001452 Entrez Gene - A searchable database of RefSeq genes. • 39069 UniProtKB/TrEMBL • Q8IH34 Q9VSW6 Q9VSW7
Other Crossreferences
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0035981 DRSC - Results from RNAi screens. • FBgn0035981 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0035981 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4452-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0035981 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39069 InParanoid A subset of ortholog calls from InParanoid. • AAEL009606-PA Aedes aegypti (mosquito) XP_391846.2 Apis mellifera (honey bee) XP_001945837.1 Acyrthosiphon pisum (pea aphid) 122985 Branchiostoma floridae (lancelet) XP_001894317.1 Brugia malayi (roundworm nematode) ENSBTAP00000026131 Bos taurus (bovine) CN09358 Caenorhabditis brenneri (small nematode) CN26721 Caenorhabditis brenneri (small nematode) CBP09268 Caenorhabditis briggsae (nematode) CE18015 Caenorhabditis elegans (worm) ENSCAFP00000006105 Canis familiaris (dog) Chro.20355 Cryptosporidium hominis (obligate parasite) JA09645 Caenorhabditis japonica (nematode) cgd2_3380 Cryptosporidium parvum (protozoan parasite) CPIJ009258 Culex pipens (mosquito) ENSCPOP00000005578 Cavia porcellus (guinea pig) RP18235 Caenorhabditis remanei (nematode) RP22127 Caenorhabditis remanei (nematode) 166048 Capitella spl (polychaete worm) 302396 Daphnia pulex (daphnia) ENSDARP00000026447 Danio rerio (zebra fish) ENSECAP00000004239 Equus caballus (horse) ENSGACP00000026934 Gymnopilus aculeatus (mushroom) ENSGALP00000027754 Gallus gallus (chicken) 71540 Hypsipyla robusta (cedar shoot borer) ENSP00000351631 Homo sapiens (human) 217061 Lottia gigantea (owl limpet) ENSMODP00000032072 Monodelphis domestica (gray opossum) ENSMMUP00000019417 Macaca mulatta (rhesus monkey) ENSMUSP00000030696 Mus musculus (house mouse) 232079 Nematostella vectensis (starlet anemone) ENSOANP00000015248 Ornithorynchus anatinus (platypus) ENSORLP00000010628 Oryzias latipes (japanese killifish) PHUM004654-PA Pediculus humanus (human body louse) PP04586 Pristionchus pacificus (nematode) ENSPPYP00000004334 Pongo pygmaeus (orangutan) ENSPTRP00000039139 Pan troglodytes (chimpanzee) ENSRNOP00000053036 Rattus norvegicus (norway rat) Smp_164990 Schistosoma mansoni (trematode parasite) XP_001182954.1 Strongylocentrotus purpuratus (purple sea urchin) XP_970598.1 Tribolium castaneum (red flour beetle) ENSTNIP00000014743 Tetraodon nigroviridis (green spotted pufferfish) TP01_0643 Theileria parva (parasitic protozoan) ENSTRUP00000039810 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015410 Xenopus tropicalis (frog) modMine - Data generated by the modENCODE project. • FBgn0035981 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16951 NV25612 LH13688 ISCW005242 FBgn0238120 FBgn0219631 FBgn0199021 FBgn0185859 FBgn0179999 JGI_V11_302396 FBgn0078201 FBgn0160031 FBgn0136663 FBgn0122060 FBgn0107617 FBgn0087728 CPIJ009259 CPIJ009258 ACYPI010058 GB14829 AGAP005928 AAEL009606 PHUM607040 GLEAN_14630
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	anon-WO0172774.118   cg4452 (Herold et al., 2003) CG4452 (Hansen et al., 2009, Keleman et al., 2009.8.5)
Name Synonym
Secondary FlyBase IDs
	FBgn0046475
References ( 14 )
Research paper	Hansen et al., 2009, PLoS Genet. 5(6): e1000525 Genome-wide identification of alternative splice forms down-regulated by nonsense-mediated mRNA decay in Drosophila. [FBrf0208149] Herold et al., 2003, EMBO J. 22(10): 2472--2483 Genome-wide analysis of nuclear mRNA export pathways in Drosophila. [FBrf0158900] Timakov et al., 2002, Genetics 160(3): 1011--1022 Timing and targeting of P-element local transposition in the male germline cells of Drosophila melanogaster. [FBrf0147053]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Bloomington Drosophila Stock Center, 2004.11.6, Exelixis insertion alleles that are not in FlyBase. Exelixis insertion alleles that are not in FlyBase. [FBrf0179797]
FlyBase analysis	FlyBase, 1996-, FlyBase inference based on genome sequence analysis. FlyBase inference based on genome sequence analysis. [FBrf0104946] FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Patent	Deak et al., 2001.10.4, World Patent 0172774-A: Cell cycle progression proteins. [FBrf0141233]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]