FlyBase Gene Report: Dmel\path

General Information

Symbol

Dmel\path

Species

D. melanogaster

Name

pathetic

Annotation Symbol

CG3424

Feature Type

protein_coding_gene

FlyBase ID

FBgn0036007

Gene Model Status

Current

Stock Availability

12 publicly available

Gene Summary

Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline (PubMed:15843412). Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197). Required in a cell-autonomous manner for dendrite growth in neurons with large dendrite arbors (PubMed:26735916, PubMed:26063572). (UniProt, Q9VT04)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

67B10-67B10

Sequence location

3L:9,494,555..9,505,328 [-]

Recombination map

3-29

RefSeq locus

NT_037436 REGION:9494555..9505328

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables amino acid transmembrane transporter activity

inferred from direct assay

(assigned by UniProt )

(Goberdhan et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables amino acid transmembrane transporter activity

inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439

(Romero-Calderon et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000535793

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in amino acid transmembrane transport

inferred from direct assay

(assigned by UniProt )

(Goberdhan et al., 2005)

involved_in dendrite extension

inferred from mutant phenotype

(Lin et al., 2015)

involved_in dendrite morphogenesis

inferred from mutant phenotype

(Lin et al., 2015)

involved_in regulation of cell projection size

inferred from mutant phenotype

(assigned by UniProt )

(Lin et al., 2015)

inferred from mutant phenotype

(Lin et al., 2015)

involved_in regulation of growth

inferred from mutant phenotype

(Goberdhan et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in amino acid transmembrane transport

inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439

(Romero-Calderon et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN000535793

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Lin et al., 2015)

located_in dendrite

inferred from direct assay

(Lin et al., 2015)

located_in endolysosome

inferred from direct assay

(Lin et al., 2015)

located_in neuronal cell body

inferred from direct assay

(Lin et al., 2015)

located_in plasma membrane

inferred from direct assay

(Lin et al., 2015)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

SLC36 FAMILY OF PROTON-COUPLED AMINO ACID TRANSPORTERS

Protein Family (UniProt)

Belongs to the amino acid/polyamine transporter 2 family. (Q9VT04)

Protein Signatures (InterPro)

Amino acid transporter, transmembrane domain

Summaries

Gene Group (FlyBase)

SLC36 FAMILY OF PROTON-COUPLED AMINO ACID TRANSPORTERS -: The solute carrier family 36 (SLC36) members are proton-coupled amino acid transmembrane transporters. (Adapted from FBrf0200993).

Protein Function (UniProtKB)

(UniProt, Q9VT04)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\path for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VT04)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

path-RA

FBtr0076427

NM_140070

2772

471

path-RD

FBtr0333864

NM_001274705

3122

471

path-RE

FBtr0333865

NM_168349

2532

458

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

path-PA

FBpp0076156

52.1

471

7.78

NP_648327

AAF50252

path-PD

FBpp0305997

52.1

471

7.78

NP_001261634

AGB94329

path-PE

FBpp0305998

50.8

458

7.95

NP_729505

AAF50253

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

471 aa isoforms: path-PA, path-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Amino acid transporter, transmembrane domain

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\path using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

path_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

head mesoderm anlage

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

antennal primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 12 -- 16

embryonic/larval tracheal section

(Chung et al., 2011)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

mushroom body primordium

Comment: reported as embryonic central brain mushroom body

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Romero-Calderon et al., 2007)

adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)

adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval peripheral nervous system

(Lin et al., 2015)

dendritic arborizing neuron

(Lin et al., 2015)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

path protein expression is observed throughout the body wall in third instar larvae. It localizes to punctate structures with cells and accumulates at junctional domains and in PNS dendrites and axons. It is found in da neurons having both small and large dendrite arbors.

(Lin et al., 2015)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon

inferred from direct assay

(Lin et al., 2015)

located_in dendrite

inferred from direct assay

(Lin et al., 2015)

located_in endolysosome

inferred from direct assay

(Lin et al., 2015)

located_in neuronal cell body

inferred from direct assay

(Lin et al., 2015)

located_in plasma membrane

inferred from direct assay

(Lin et al., 2015)

Expression Deduced from Reporters

Reporter: P{GawB}path^c135

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic/larval proventriculus

(Kester and Nambu, 2011)

embryonic/larval gut

(Kester and Nambu, 2011)

embryonic stage 16

embryonic proventriculus | restricted

(Hrdlicka et al., 2002)

third instar larval stage -- pupal stage P7

embryonic/larval carpet glial cell

(Yeh et al., 2018)

late third instar larval stage

embryonic/larval brain

(Hrdlicka et al., 2002)

embryonic/larval gut

(Hrdlicka et al., 2002)

glial cell of eye disc

(Hrdlicka et al., 2002)

embryonic/larval fat body

(Hrdlicka et al., 2002)

adult stage

neuron | subset of adult brain

(Lai et al., 2012)

antennal mechanosensory and motor center B1a projection neuron

(Lai et al., 2012)

adult stage | male

seminal vesicle

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

male accessory gland secondary cell

(Hrdlicka et al., 2002)

ejaculatory duct

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

cyst cell of testis

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

spermatocyte

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

male accessory gland

(Kester and Nambu, 2011)

adult stage | female

stretch follicle cell

(Kester and Nambu, 2011)

polar follicle cell

Comment: posterior

(Kester and Nambu, 2011)

adult stage | female & oogenesis stage S10

stretch follicle cell

(Hrdlicka et al., 2002)

centripetal follicle cell

(Hrdlicka et al., 2002)

adult stage | female oogenesis stage S9 -- S10

follicle cell | posterior | subset

(Hrdlicka et al., 2002)

Reporter: PBac{768.FSVS-0}path^CPTI003513

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

Comment: punctate expression throughout adult brain

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\path in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\path

View exonic expression by tissue for Dmel\path

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036007

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39106/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036007

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3424

Flygut - An atlas of the Drosophila adult midgut

FBgn0036007

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\path

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of path

Transgenic constructs containing regulatory region of path

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)BSC773

(Lin et al., 2015, Christensen et al., 2009.5.6)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

path^GD2391

viable, with Scer\GAL4^pnr-MD237

path^GD2391

viable, with Scer\GAL4^tin.CΔ4

path^GD2391

Sterility

Allele

female sterile

path^KG06640

female sterile (with Df(3L)AC1)

path^KG06640

fertile

path^GFP

Other Phenotypes

Allele

abnormal developmental rate

path^KG06640

abnormal developmental rate (with Df(3L)AC1)

path^KG06640

abnormal eclosion rhythm

path^KG06640

abnormal neuroanatomy, with Scer\GAL4²²¹

path^A.UAS.GFP

abnormal neuroanatomy | cell autonomous | somatic clone

path^dg50

abnormal neuroanatomy | germline clone | larval stage

path^dg50

abnormal neuroanatomy | larval stage

path^Δ

abnormal neuroanatomy | larval stage (with Df(3L)BSC773)

abnormal neuroanatomy | larval stage (with path^dg50)

path^KG06640

abnormal neuroanatomy | larval stage (with path^KG06640)

path^dg50

abnormal neuroanatomy | larval stage | progressive (with Df(3L)BSC773)

path^dg50

abnormal neuroanatomy | larval stage | recessive

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^path-c135

path^KK104735

abnormal size, with Scer\GAL4^en-e16E

path^KK104735

decreased body size

path^KG06640

decreased body size (with Df(3L)AC1)

path^KG06640

decreased cell number

path^KG06640

decreased cell number, with Scer\GAL4^en-e16E

decreased cell number | larval stage | somatic clone

path^KG06640

decreased cell size

path^KG06640

decreased cell size, with Scer\GAL4^nub-AC-62

path^UAS.cGa

decreased fecundity | female

path^KG06640

decreased occurrence of cell division | larval stage | somatic clone

path^KG06640

decreased size | larval stage | nutrition conditional

path^dg50

decreased size | larval stage | nutrition conditional, with Scer\GAL4^repo

path^KK104735

increased cell number, with Scer\GAL4^nub-AC-62

path^UAS.cGa

increased cell size, with Scer\GAL4^en-e16E

increased cell size | larval stage, with Scer\GAL4^insc-Mz1407

path^KK104735

increased cell size | larval stage | somatic clone

path^KG06640

Phenotype manifest in

Allele

abdominal dorsal multidendritic neuron ddaA

path^dg50

abdominal dorsal multidendritic neuron ddaC

abdominal dorsal multidendritic neuron ddaC (with Df(3L)BSC773)

abdominal dorsal multidendritic neuron ddaC (with path^dg50)

path^KG06640

abdominal dorsal multidendritic neuron ddaC (with path^KG06640)

path^dg50

abdominal dorsal multidendritic neuron ddaC | germline clone

path^dg50

abdominal dorsal multidendritic neuron ddaF

path^dg50

adult fat body

path^KG06640

adult salivary gland

path^KG06640

axon | larval stage | progressive (with Df(3L)BSC773)

path^dg50

dendrite | larval stage

path^Δ

dendrite | larval stage (with Df(3L)BSC773)

embryonic/larval brain | larval stage | nutrition conditional

path^dg50

embryonic/larval brain | larval stage | nutrition conditional, with Scer\GAL4^repo

path^KK104735

embryonic/larval carpet glial cell | third instar larval stage, with Scer\GAL4^path-c135

path^KK104735

eye, with Scer\GAL4^GMR.PF

eye (with path^GS11111), with Scer\GAL4^GMR.PF

path^GS13857

eye (with path^GS13857), with Scer\GAL4^GMR.PF

path^GS11111

eye disc | third instar larval stage, with Scer\GAL4^path-c135

path^KK104735

larval multidendritic class I neuron, with Scer\GAL4²²¹

path^A.UAS.GFP

larval multidendritic class IV neuron | cell autonomous | somatic clone

path^dg50

larval multidendritic class IV neuron | larval stage

path^Δ

larval multidendritic class IV neuron | larval stage (with Df(3L)BSC773)

larval multidendritic class IV neuron | larval stage | progressive (with Df(3L)BSC773)

path^dg50

larval neuroblast, with Scer\GAL4^insc-Mz1407

path^KK104735

larval neuroblast | decreased number | somatic clone

path^KG06640

ommatidium

path^KG06640

ommatidium, with Scer\GAL4^GMR.PF

ommatidium (with path^GS11111), with Scer\GAL4^GMR.PF

path^GS13857

ommatidium (with path^GS13857), with Scer\GAL4^GMR.PF

path^GS11111

wing

path^KG06640

wing, with Scer\GAL4^Bx-MS1096

path^GS13857

wing, with Scer\GAL4^en-e16E

wing, with Scer\GAL4^nub-AC-62

path^UAS.cGa

wing | posterior, with Scer\GAL4^en-e16E

path^KK104735

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC36A1

6 of 15

Yes

Hsap\SLC36A2

6 of 15

Yes

Hsap\SLC36A3

6 of 15

Yes

Hsap\SLC36A4

6 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc36a1

6 of 15

Yes

Mmus\Slc36a2

6 of 15

Yes

Mmus\Slc36a3

6 of 15

Yes

5 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Slc36a1

6 of 13

Yes

Rnor\Slc36a2

6 of 13

Yes

Rnor\Slc36a3

6 of 13

Yes

Rnor\Slc36a4

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (11)

Xtro\slc36a1

5 of 12

Yes

Xtro\slc36a4

5 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (17)

Drer\slc36a4

6 of 15

Yes

Drer\slc36a1

5 of 15

Drer\atox1

1 of 15

Drer\LOC100536170

1 of 15

Drer\si:dkey-126h10.1

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\Y43F4B.7

7 of 15

Yes

Cele\slc-36.2

6 of 15

Cele\skat-1

5 of 15

Yes

Cele\slc-36.3

5 of 15

Cele\slc-36.4

5 of 15

Cele\slc-36.5

4 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (10)

Atha\ANT1

8 of 9

Yes

7 of 9

7 of 9

6 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\AVT3

7 of 15

Yes

Scer\AVT4

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\avt3

6 of 12

Yes

Spom\avt5

1 of 12

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

3 of 10

2 of 10

mah

2 of 10

VGAT

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

SLC36A2; solute carrier family 36 member 2

model of iminoglycinuria

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC36A1; solute carrier family 36 member 1

6 of 15

606561

SLC36A2; solute carrier family 36 member 2

6 of 15

608331

iminoglycinuria

SLC36A3; solute carrier family 36 member 3

6 of 15

608332

SLC36A4; solute carrier family 36 member 4

6 of 15

613760

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

path - lark

pull down, quantitative reverse transcription pcr

(Swain et al., 2016)

path - orb2

pull down, western blot

(Mastushita-Sakai et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

foxo|path

suppressible

Akt

(Goberdhan et al., 2005)

path

suppressible

CG1139

(Goberdhan et al., 2005)

suppressible

(Lin et al., 2015)

suppressible

(Resnik-Docampo and de Celis, 2011)

path

enhanceable

hppy

(Resnik-Docampo and de Celis, 2011)

suppressible

(Lin et al., 2015)

suppressible

(Lin et al., 2015)

enhanceable

(Goberdhan et al., 2005)

path

suppressible

Tsc1|gig

(Goberdhan et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

path

(Lin et al., 2015)

foxo

enhanceable

path

(Goberdhan et al., 2005)

foxo

enhanceable

Tor|path

(Goberdhan et al., 2005)

gig

suppressible

path

(Goberdhan et al., 2005)

Tor

enhanceable

path

(Goberdhan et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64498

DroID - A comprehensive database of gene and protein interactions.

FBgn0036007

MIST (genetic) - An integrated Molecular Interaction Database

path

MIST (protein-protein) - An integrated Molecular Interaction Database

path

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036007

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-29

Cytogenetic map

67B10-67B10

Sequence location

3L:9,494,555..9,505,328 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67B10-67B10

Limits computationally determined from genome sequence between P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315 and P{PZ}fry⁰²²⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-29

(FlyBase, 2016)

3-23.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

6978

w¹¹¹⁸; P{GawB}path^c135

33168

y¹ w^*; Mi{MIC}path^MI02163

64029

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05365}attP40

14607

y¹; P{SUPor-P}path^KG06640 ry⁵⁰⁶/TM3, Sb¹ Ser¹

Kyoto

108995

w¹¹¹⁸; P{GawB}path^c135

115415

w¹¹¹⁸; PBac{768.FSVS-0}path^CPTI003513

203076

y¹ w^67c23; P{GSV6}path^GS11111/TM3, Sb¹ Ser¹

204997

y¹ w^67c23; P{GSV6}path^GS13857/TM3, Sb¹ Ser¹

111613

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{SUPor-P}path^KG06640 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

VDRC

v100519

P{KK104735}VIE-260B

v44536

w¹¹¹⁸ P{GD2391}v44536

v44537

w¹¹¹⁸ P{GD2391}v44537

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (130)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP04528

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036007

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036007

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39106

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Feng et al., 2020, Lin et al., 2015)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: path CG3424

(Goberdhan, 2005.3.11)

Source for database merge of

Source for merge of: path anon-WO0118547.271 anon-WO0118547.370

(FlyBase, 1996-)

Additional comments

Source for merge of path anon-WO0118547.271 anon-WO0118547.370 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Area matching Drosophila EST AA567141 (inverted).

(Davies, 2001.3.15)

Area matching Drosophila EST AA735277. This EST forms a 1176bp contig with EST AA697907.

(Davies, 2001.3.15)

Origin and Etymology

Discoverer

Etymology

The name "pathetic" is derived from the reduced growth phenotypes of mutants.

(Goberdhan et al., 2005)

Identification

External Crossreferences and Linkouts ( 53 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39106

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VT04

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VT04

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VT03

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VT04

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036007

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036007

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39106/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0036007

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

path_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0036007

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0036007

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3424

Flygut - An atlas of the Drosophila adult midgut

FBgn0036007

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0036007

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39106

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

Amino acid transporter, transmembrane domain

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3424

MARRVEL_MODEL - MARRVEL (model organism gene)

39106

modMine - A data warehouse for the modENCODE project

FBgn0036007

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

14607-path[KG06640]

BioGRID - A database of protein and genetic interactions.

64498

DroID - A comprehensive database of gene and protein interactions.

FBgn0036007

DRSC - Results frm RNAi screens

FBgn0036007

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036007

FlyMine - An integrated database for Drosophila genomics

FBgn0036007

MIST (genetic) - An integrated Molecular Interaction Database

path

MIST (protein-protein) - An integrated Molecular Interaction Database

path

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG3424

(Çiçek et al., 2016, Limmer et al., 2014, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Biehs et al., 2010, Cox and Spradling, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Romero-Calderon et al., 2007, Goberdhan et al., 2005)

Path

(Hou and Pei, 2021, Lam Wong and Verheyen, 2021, Chung et al., 2011)

Pathetic

(Mastushita-Sakai et al., 2010)

anon-WO0118547.271

anon-WO0118547.370

pth

(Resnik-Docampo and de Celis, 2011)

Name Synonyms

Pathetic

(Weiler et al., 2017, Chandran et al., 2014)

pathetic

(Ho et al., 2019, Jaspers et al., 2012, Cammarato et al., 2011, LaFerriere et al., 2008, Goberdhan, 2005.3.11)

Secondary FlyBase IDs

FBgn0062062
FBgn0062128

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (86)

The following external sites may use different assemblies or annotations than FlyBase.

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