FlyBase Gene Report: Dmel\path

SLC36 FAMILY OF PROTON-COUPLED AMINO ACID TRANSPORTERS -: The solute carrier family 36 (SLC36) members are proton-coupled amino acid transmembrane transporters. (Adapted from FBrf0200993).

Protein Function (UniProtKB)

Amino acid transporter which has pH-dependent electrogenic transport activity for alanine and glycine but not for proline (PubMed:15843412). Plays a role in positive regulation of growth by directly or indirectly modulating the effects of the TOR signaling pathway (PubMed:15843412, PubMed:22574197). Required in a cell-autonomous manner for dendrite growth in neurons with large dendrite arbors (PubMed:26735916, PubMed:26063572).

(UniProt, Q9VT04)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\path or the JBrowse view of Dmel\path for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

path-RA

FBtr0076427

NM_140070

2772

471

path-RD

FBtr0333864

NM_001274705

3122

471

path-RE

FBtr0333865

NM_168349

2532

458

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

path-PA

FBpp0076156

52.1

471

7.78

NP_648327

AAF50252

path-PD

FBpp0305997

52.1

471

7.78

NP_001261634

AGB94329

path-PE

FBpp0305998

50.8

458

7.95

NP_729505

AAF50253

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

471 aa isoforms: path-PA, path-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Amino acid transporter, transmembrane domain

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\path using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

path_1

Linkouts

Gene Ontology (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

amino acid transmembrane transporter activity

inferred from direct assay

(assigned by UniProt )

(Goberdhan et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

amino acid transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000535793

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439

(Romero-Calderon et al., 2007)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

amino acid transmembrane transport

inferred from direct assay

(assigned by UniProt )

(Goberdhan et al., 2005)

dendrite extension

inferred from mutant phenotype

(Lin et al., 2015)

dendrite morphogenesis

inferred from mutant phenotype

(Lin et al., 2015)

regulation of cell projection size

inferred from mutant phenotype

(Lin et al., 2015)

inferred from mutant phenotype

(assigned by UniProt )

(Lin et al., 2015)

regulation of growth

inferred from mutant phenotype

(Goberdhan et al., 2005)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

amino acid transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000535793

(assigned by GO_Central )

(Gaudet et al., 2011)

inferred from sequence or structural similarity with FLYBASE:Eaat1; FB:FBgn0026439

(Romero-Calderon et al., 2007)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

axon

inferred from direct assay

(Lin et al., 2015)

dendrite

inferred from direct assay

(Lin et al., 2015)

endolysosome

inferred from direct assay

(Lin et al., 2015)

neuronal cell body

inferred from direct assay

(Lin et al., 2015)

plasma membrane

inferred from direct assay

(Lin et al., 2015)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

vacuolar membrane

inferred from biological aspect of ancestor with PANTHER:PTN001119389

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

head mesoderm anlage

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

antennal primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

central brain primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

dorsal head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

lateral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

ventral head epidermis primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

visual primordium

Comment: reported as procephalon primordium

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

somatic muscle primordium

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

visceral muscle primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

mushroom body primordium

Comment: reported as embryonic central brain mushroom body

(Fisher et al., 2012)

embryonic stage 12 -- 16

embryonic/larval trachea

(Chung et al., 2011)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Romero-Calderon et al., 2007)

adult thorax

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)

adult abdomen

Comment: Thorax and abdomen assayed together.

(Romero-Calderon et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval peripheral nervous system

(Lin et al., 2015)

dendritic arborizing neuron

(Lin et al., 2015)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

path protein expression is observed throughout the body wall in third instar larvae. It localizes to punctate structures with cells and accumulates at junctional domains and in PNS dendrites and axons. It is found in da neurons having both small and large dendrite arbors.

(Lin et al., 2015)

Marker for

Subcellular Localization

CV Term

Evidence

References

axon

inferred from direct assay

(Lin et al., 2015)

dendrite

inferred from direct assay

(Lin et al., 2015)

endolysosome

inferred from direct assay

(Lin et al., 2015)

neuronal cell body

inferred from direct assay

(Lin et al., 2015)

plasma membrane

inferred from direct assay

(Lin et al., 2015)

Expression Deduced from Reporters

Reporter: P{GawB}path^c135

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

neuron | subset of adult brain

(Lai et al., 2012)

antennal mechanosensory and motor center B1a projection neuron

(Lai et al., 2012)

adult stage | female & oogenesis stage S10

nurse follicle cell

(Hrdlicka et al., 2002)

centripetally migrating follicle cell

(Hrdlicka et al., 2002)

adult stage | female oogenesis stage S9 -- S10

follicle cell | posterior | subset

(Hrdlicka et al., 2002)

adult stage | male

seminal vesicle

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

male accessory gland secondary cell

(Hrdlicka et al., 2002)

ejaculatory duct

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

cyst cell

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

spermatocyte

(Kester and Nambu, 2011, Hrdlicka et al., 2002)

male accessory gland

(Kester and Nambu, 2011)

embryonic stage 16

embryonic proventriculus | restricted

(Hrdlicka et al., 2002)

late third instar larval stage

embryonic/larval brain

(Hrdlicka et al., 2002)

embryonic/larval gut

(Hrdlicka et al., 2002)

glial cell of eye disc

(Hrdlicka et al., 2002)

embryonic/larval fat body

(Hrdlicka et al., 2002)

embryonic stage

embryonic/larval proventriculus

(Kester and Nambu, 2011)

embryonic/larval gut

(Kester and Nambu, 2011)

adult stage | female

nurse follicle cell

(Kester and Nambu, 2011)

polar follicle cell

Comment: posterior

(Kester and Nambu, 2011)

Reporter: PBac{768.FSVS-0}path^CPTI003513

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

Comment: punctate expression throughout adult brain

(Knowles-Barley, 2011.8.24)

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\path in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\path

View exonic expression by tissue for Dmel\path

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036007

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0036007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3424-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3424

Flygut - An atlas of the Drosophila adult midgut

FBgn0036007

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\path

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 12 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of path

Transgenic constructs containing regulatory region of path

Deletions and Duplications ( 1 )

Disrupted in

Df(3L)BSC773

(Lin et al., 2015, Christensen et al., 2009.5.6)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

path^GD2391

viable, with Scer\GAL4^pnr-MD237

path^GD2391

viable, with Scer\GAL4^tin.CΔ4

path^GD2391

Sterility

Allele

female sterile

path^KG06640

female sterile (with Df(3L)AC1)

path^KG06640

fertile

path^GFP

Other Phenotypes

Allele

decreased cell number

path^KG06640

decreased cell number, with Scer\GAL4^en-e16E

decreased cell size

path^KG06640

decreased cell size, with Scer\GAL4^nub-AC-62

path^UAS.cGa

decreased fecundity | female

path^KG06640

developmental rate defective

path^KG06640

developmental rate defective (with Df(3L)AC1)

path^KG06640

eclosion rhythm defective

path^KG06640

increased cell number, with Scer\GAL4^nub-AC-62

path^UAS.cGa

increased cell size, with Scer\GAL4^en-e16E

neuroanatomy defective, with Scer\GAL4²²¹

path^A.UAS.GFP

neuroanatomy defective | cell autonomous | somatic clone

path^dg50

neuroanatomy defective | germline clone | larval stage

path^dg50

neuroanatomy defective | larval stage

path^Δ

neuroanatomy defective | larval stage (with Df(3L)BSC773)

neuroanatomy defective | larval stage (with path^dg50)

path^KG06640

neuroanatomy defective | larval stage (with path^KG06640)

path^dg50

neuroanatomy defective | larval stage | progressive (with Df(3L)BSC773)

path^dg50

neuroanatomy defective | larval stage | recessive

size defective, with Scer\GAL4^en-e16E

path^KK104735

small body

path^KG06640

small body (with Df(3L)AC1)

path^KG06640

Phenotype manifest in

Allele

abdominal dorsal multidendritic neuron ddaA

path^dg50

abdominal dorsal multidendritic neuron ddaC

abdominal dorsal multidendritic neuron ddaC (with Df(3L)BSC773)

abdominal dorsal multidendritic neuron ddaC (with path^dg50)

path^KG06640

abdominal dorsal multidendritic neuron ddaC (with path^KG06640)

path^dg50

abdominal dorsal multidendritic neuron ddaC | germline clone

path^dg50

abdominal dorsal multidendritic neuron ddaF

path^dg50

adult fat body

path^KG06640

adult salivary gland

path^KG06640

axon | larval stage | progressive (with Df(3L)BSC773)

path^dg50

dendrite | larval stage

path^Δ

dendrite | larval stage (with Df(3L)BSC773)

eye, with Scer\GAL4^GMR.PF

eye (with path^GS11111), with Scer\GAL4^GMR.PF

path^GS13857

eye (with path^GS13857), with Scer\GAL4^GMR.PF

path^GS11111

larval multidendritic class I neuron, with Scer\GAL4²²¹

path^A.UAS.GFP

larval multidendritic class IV neuron | cell autonomous | somatic clone

path^dg50

larval multidendritic class IV neuron | larval stage

path^Δ

larval multidendritic class IV neuron | larval stage (with Df(3L)BSC773)

larval multidendritic class IV neuron | larval stage | progressive (with Df(3L)BSC773)

path^dg50

ommatidium

path^KG06640

ommatidium, with Scer\GAL4^GMR.PF

ommatidium (with path^GS11111), with Scer\GAL4^GMR.PF

path^GS13857

ommatidium (with path^GS13857), with Scer\GAL4^GMR.PF

path^GS11111

wing

path^KG06640

wing, with Scer\GAL4^Bx-MS1096

path^GS13857

wing, with Scer\GAL4^en-e16E

wing, with Scer\GAL4^nub-AC-62

path^UAS.cGa

wing | posterior, with Scer\GAL4^en-e16E

path^KK104735

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\SLC36A1

6 of 15

Yes

Hsap\SLC36A2

6 of 15

Yes

Hsap\SLC36A3

6 of 15

Yes

Hsap\SLC36A4

6 of 15

Yes

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Slc36a1

6 of 15

Yes

Mmus\Slc36a2

6 of 15

Yes

Mmus\Slc36a3

6 of 15

Yes

5 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Slc36a1

6 of 13

Yes

Rnor\Slc36a2

6 of 13

Yes

Rnor\Slc36a3

6 of 13

Yes

Rnor\Slc36a4

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (11)

Xtro\slc36a1

5 of 12

Yes

Xtro\slc36a4

5 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (17)

Drer\slc36a4

6 of 15

Yes

Drer\slc36a1

5 of 15

Drer\atox1

1 of 15

Drer\LOC100536170

1 of 15

Drer\si:dkey-126h10.1

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\Y43F4B.7

7 of 15

Yes

Cele\slc-36.2

6 of 15

Cele\skat-1

5 of 15

Yes

Cele\slc-36.3

5 of 15

Cele\slc-36.4

5 of 15

Cele\slc-36.5

4 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (10)

Atha\ANT1

8 of 9

Yes

7 of 9

7 of 9

6 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\AVT3

7 of 15

Yes

Scer\AVT4

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\avt3

6 of 12

Yes

Spom\avt5

1 of 12

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908BB )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17443

Drosophila persimilis

Dper\GL17962

Drosophila willistoni

Dwil\GK10461

Drosophila virilis

Dvir\GJ13356

Drosophila mojavensis

Dmoj\GI12085

Drosophila grimshawi

Dgri\GH15148

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505BM )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17019781

Musca domestica

House fly

Mdoa\17017412

Glossina morsitans

Tsetse fly

Gmor\GMOY000882

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_03137

Mayetiola destructor

Hessian fly

Mdes\Mdes000576

Anopheles darlingi

American malaria mosquito

Adar\ADAC007168

Anopheles gambiae

Malaria mosquito

Agam\AGAP007633

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ002058

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W07LG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA010585

Bombyx mori

Silkmoth

Bmor\BGIBMGA003882

Bombyx mori

Silkmoth

Bmor\BGIBMGA001299

Bombyx mori

Silkmoth

Bmor\BGIBMGA003854

Bombyx mori

Silkmoth

Bmor\BGIBMGA000714

Bombyx mori

Silkmoth

Bmor\BGIBMGA012328

Bombyx mori

Silkmoth

Bmor\BGIBMGA003894

Bombyx mori

Silkmoth

Bmor\BGIBMGA000844

Bombyx mori

Silkmoth

Bmor\BGIBMGA014209

Danaus plexippus

Monarch butterfly

Dple\DPOGS206040-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202647-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202677-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202644-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS205792-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS203920-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS203368-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202676-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202641-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202985-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS202993-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL012049

Heliconius melpomene

Postman butterfly

Hmel\HMEL013529

Heliconius melpomene

Postman butterfly

Hmel\HMEL006630

Heliconius melpomene

Postman butterfly

Hmel\HMEL017944

Heliconius melpomene

Postman butterfly

Hmel\HMEL011030

Heliconius melpomene

Postman butterfly

Hmel\HMEL011041

Heliconius melpomene

Postman butterfly

Hmel\HMEL005610

Heliconius melpomene

Postman butterfly

Hmel\HMEL008069

Heliconius melpomene

Postman butterfly

Hmel\HMEL007853

Apis florea

Little honeybee

Aflo\2268280916

Apis florea

Little honeybee

Aflo\3243285332

Apis florea

Little honeybee

Aflo\4655684820

Apis florea

Little honeybee

Aflo\2709615700

Apis florea

Little honeybee

Aflo\2147492387

Apis florea

Little honeybee

Aflo\3268457364

Apis mellifera

Western honey bee

Amel\GB51487

Apis mellifera

Western honey bee

Amel\LOC409640

Apis mellifera

Western honey bee

Amel\LOC413117

Apis mellifera

Western honey bee

Amel\LOC410741

Apis mellifera

Western honey bee

Amel\path

Apis mellifera

Western honey bee

Amel\GB46287

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10410

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP20587

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13159

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13160

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22071

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP22998

Bombus terrestris

Buff-tailed bumblebee

Bter\15214248

Bombus terrestris

Buff-tailed bumblebee

Bter\15215988

Bombus terrestris

Buff-tailed bumblebee

Bter\15207620

Bombus terrestris

Buff-tailed bumblebee

Bter\15210591

Bombus terrestris

Buff-tailed bumblebee

Bter\15207622

Bombus terrestris

Buff-tailed bumblebee

Bter\15209859

Linepithema humile

Argentine ant

Lhum\LH12500

Linepithema humile

Argentine ant

Lhum\LH12499

Linepithema humile

Argentine ant

Lhum\LH19947

Linepithema humile

Argentine ant

Lhum\LH13628

Linepithema humile

Argentine ant

Lhum\LH11213

Linepithema humile

Argentine ant

Lhum\LH12579

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002152

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001a59

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002812

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001608

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002150

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001f18

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014885

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003403

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014888

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014953

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG025482

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG003404

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG005587

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_08975

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01779

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06466

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_07866

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03638

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12278

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06465

Tribolium castaneum

Red flour beetle

Tcas\TC002388

Tribolium castaneum

Red flour beetle

Tcas\TC031063

Tribolium castaneum

Red flour beetle

Tcas\TC002617

Tribolium castaneum

Red flour beetle

Tcas\TC034675

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08150

Tribolium castaneum

Red flour beetle

Tcas\TC002389

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_08149

Tribolium castaneum

Red flour beetle

Tcas\TC032584

Tribolium castaneum

Red flour beetle

Tcas\TC002616

Tribolium castaneum

Red flour beetle

Tcas\GLEAN_07297

Pediculus humanus

Human body louse

Phum\PHUM540430

Pediculus humanus

Human body louse

Phum\PHUM540490

Pediculus humanus

Human body louse

Phum\PHUM539910

Pediculus humanus

Human body louse

Phum\PHUM614600

Pediculus humanus

Human body louse

Phum\PHUM590280

Pediculus humanus

Human body louse

Phum\PHUM540020

Rhodnius prolixus

Kissing bug

Rpro\RPRC012282

Rhodnius prolixus

Kissing bug

Rpro\RPRC013669

Rhodnius prolixus

Kissing bug

Rpro\RPRC010302

Rhodnius prolixus

Kissing bug

Rpro\RPRC013585

Rhodnius prolixus

Kissing bug

Rpro\RPRC010877

Rhodnius prolixus

Kissing bug

Rpro\RPRC007600

Rhodnius prolixus

Kissing bug

Rpro\RPRC007319

Rhodnius prolixus

Kissing bug

Rpro\RPRC011833

Rhodnius prolixus

Kissing bug

Rpro\RPRC013645

Cimex lectularius

Bed bug

Clec\CLEC005343

Cimex lectularius

Bed bug

Clec\CLEC005344

Cimex lectularius

Bed bug

Clec\CLEC005349

Cimex lectularius

Bed bug

Clec\CLEC002486

Cimex lectularius

Bed bug

Clec\CLEC006580

Cimex lectularius

Bed bug

Clec\CLEC000519

Cimex lectularius

Bed bug

Clec\CLEC002482

Cimex lectularius

Bed bug

Clec\CLEC001199

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI007681

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008957

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005519

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001684

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001018

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008849

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001366

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006258

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI008971

Acyrthosiphon pisum

Pea aphid

Apim\ind-1

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000536

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000550

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_12149

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08660

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08145

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08665

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08659

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_08393

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17475

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X092U )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR008586

Ixodes scapularis

Black-legged tick

Isca\ISCW008063

Stegodyphus mimosarum

African social velvet spider

Smim\KFM61399.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g11220

Tetranychus urticae

Two-spotted spider mite

Turt\tetur01g11240

Tetranychus urticae

Two-spotted spider mite

Turt\tetur32g02020

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_94786

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_94788

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_191089

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310272

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_310275

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G079T )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc36a1_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Slc36a1_2

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_011346gn

Ciona intestinalis

Vase tunicate

Cint\LOC100187544

Gallus gallus

Domestic chicken

Ggal\SLC36A4

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000004351

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (14)

Gene Symbol

Score

Source

Alignment

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

5 of 10

4 of 10

3 of 10

2 of 10

mah

2 of 10

VGAT

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC36A1; solute carrier family 36 member 1

6 of 15

606561

SLC36A2; solute carrier family 36 member 2

6 of 15

608331

SLC36A3; solute carrier family 36 member 3

6 of 15

608332

SLC36A4; solute carrier family 36 member 4

6 of 15

613760

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

path - lark

pull down, quantitative reverse transcription pcr

(Swain et al., 2016)

path - orb2

pull down, western blot

(Mastushita-Sakai et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

foxo|path

suppressible

Akt1

(Goberdhan et al., 2005)

path

suppressible

CG1139

(Goberdhan et al., 2005)

suppressible

(Lin et al., 2015)

suppressible

(Resnik-Docampo and de Celis, 2011)

path

enhanceable

hppy

(Resnik-Docampo and de Celis, 2011)

suppressible

(Lin et al., 2015)

suppressible

(Lin et al., 2015)

enhanceable

(Goberdhan et al., 2005)

path

suppressible

Tsc1|gig

(Goberdhan et al., 2005)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

path

(Lin et al., 2015)

foxo

enhanceable

Tor|path

(Goberdhan et al., 2005)

foxo

enhanceable

path

(Goberdhan et al., 2005)

gig

suppressible

path

(Goberdhan et al., 2005)

Tor

enhanceable

path

(Goberdhan et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64498

DroID - A comprehensive database of gene and protein interactions.

FBgn0036007

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39106

MIST (genetic) - An integrated Molecular Interaction Database

path

MIST (protein-protein) - An integrated Molecular Interaction Database

path

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-29

Cytogenetic map

67B10-67B10

Sequence location

3L:9,494,555..9,505,328 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

67B10-67B10

Limits computationally determined from genome sequence between P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315 and P{PZ}fry⁰²²⁴⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-29

(FlyBase, 2016)

3-23.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Bloomington

6978

w¹¹¹⁸; P{GawB}path^c135

33168

y¹ w^*; Mi{MIC}path^MI02163

64029

y¹ sc^* v¹ sev²¹; P{TRiP.HMS05365}attP40

14607

y¹; P{SUPor-P}path^KG06640 ry⁵⁰⁶/TM3, Sb¹ Ser¹

Kyoto

108995

w¹¹¹⁸; P{GawB}path^c135

115415

w¹¹¹⁸; PBac{768.FSVS-0}path^CPTI003513

203076

y¹ w^67c23; P{GSV6}path^GS11111/TM3, Sb¹ Ser¹

204997

y¹ w^67c23; P{GSV6}path^GS13857/TM3, Sb¹ Ser¹

111613

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{SUPor-P}path^KG06640 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

VDRC

v100519

P{KK104735}VIE-260B

v44536

w¹¹¹⁸ P{GD2391}v44536

v44537

w¹¹¹⁸ P{GD2391}v44537

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (130)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

Other clones

MIP04528

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0036007

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0036007

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39106

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lin et al., 2015)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: path CG3424

(Goberdhan, 2005.3.11)

Source for database merge of

Source for merge of: path anon-WO0118547.271 anon-WO0118547.370

(FlyBase, 1996-)

Additional comments

Source for merge of path anon-WO0118547.271 anon-WO0118547.370 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

Area matching Drosophila EST AA567141 (inverted).

(Davies, 2001.3.15)

Area matching Drosophila EST AA735277. This EST forms a 1176bp contig with EST AA697907.

(Davies, 2001.3.15)

Origin and Etymology

Discoverer

Etymology

The name "pathetic" is derived from the reduced growth phenotypes of mutants.

(Goberdhan et al., 2005)

Identification

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39106

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VT04

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VT03

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0036007

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0036007

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

path_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3424

Flygut - An atlas of the Drosophila adult midgut

FBgn0036007

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

39106

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

Amino acid transporter, transmembrane domain

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3424

modMine - A data warehouse for the modENCODE project

FBgn0036007

Linkouts

ApoDroso - Functional genomic database for photoreceptor development, survival and function

14607-path[KG06640]

BioGRID - A database of protein and genetic interactions.

64498

DroID - A comprehensive database of gene and protein interactions.

FBgn0036007

DRSC - Results frm RNAi screens

FBgn0036007

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0036007

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3424-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0036007

FlyMine - An integrated database for Drosophila genomics

FBgn0036007

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

39106

MIST (genetic) - An integrated Molecular Interaction Database

path

MIST (protein-protein) - An integrated Molecular Interaction Database

path

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG3424

(Çiçek et al., 2016, Limmer et al., 2014, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Biehs et al., 2010, Cox and Spradling, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Romero-Calderon et al., 2007, Goberdhan et al., 2005)

Path

(Chung et al., 2011)

Pathetic

(Mastushita-Sakai et al., 2010)

anon-WO0118547.271

anon-WO0118547.370

pth

(Resnik-Docampo and de Celis, 2011)

Name Synonyms

Pathetic

(Weiler et al., 2017, Chandran et al., 2014)

pathetic

(Ho et al., 2019, Jaspers et al., 2012, Cammarato et al., 2011, LaFerriere et al., 2008, Goberdhan, 2005.3.11)

Secondary FlyBase IDs

FBgn0062062
FBgn0062128

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (75)

Report Sections

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