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Gene Dmel\CG8336

General Information
Symbol	Dmel\CG8336	Species	D. melanogaster
Name		Annotation symbol	CG8336
Feature type	protein_coding_gene	FlyBase ID	FBgn0036020
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C2-67C3	Sequence location	3L:9,621,776..9,624,895 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG8336 (FBgn0036020). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: binding; peptidyl-prolyl cis-trans isomerase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: protein folding. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Cyclophilin-like; Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; Tetratricopeptide TPR-1; Tetratricopeptide repeat; Tetratricopeptide repeat-containing; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1635293_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of CG8336. Gene sequence location is 3L:9621776..9624895.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features HFA10980 BKN21717
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C2-67C3   Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG8336 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG8336-RA FBtr0076385  NM_140081   1500   383 CG8336-RB FBtr0076384  NM_168354   1555   383 CG8336-RC FBtr0076386  NM_168355   1443   383
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG8336-PA   FBpp0076114   43.1   383   7.77     NP_648338   AAN11947 CG8336-PB   FBpp0076113   43.1   383   7.77     NP_729517   AAN11948 CG8336-PC   FBpp0076115   43.1   383   7.77     NP_729518   AAF50235
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (IPR002130) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Cyclophilin-like (IPR015891) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201683   AA392417   AE014296 AAF50235   AE014296 AAN11947   AE014296 AAN11948   AI107102   AI135221   AI389222   AI402046   AI946971   AY058303 AAL13532   BF495102   BF498690   BF501027   BF503525   BF505007   BF506739   BI366355   BI481815   BI482624   CO270331   CO328193   CO334054   EC068426   EC197315   EC223988   EC254191   GH955376   GH958635   GH962188   GH963641   GH968740   GH974415   GH977013   GH979844   GH983279   GH983474   GH983947
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VT21
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036020    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036020 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036020 expression level Developmental Stage   Expression Level embryo 00-02hr    2727 embryo 02-04hr    2522 embryo 04-06hr    1836 embryo 06-08hr    1689 embryo 08-10hr    1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr    1617 embryo 22-24hr    1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9    1560 white prepupae new    1603 white prepupae 12hr    3427 white prepupae 24hr    3122 pupae 2d postWPP    2400 pupae 3d postWPP    1902 pupae 4d postWPP    1413 adult male 01day    1672 adult male 05day    2274 adult male 30day    2260 adult female 01day    1377 adult female 05day    1788 adult female 30day    1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2727) embryo 02-04hr  (2522) embryo 04-06hr  (1836) embryo 06-08hr  (1689) embryo 08-10hr  (1675) embryo 10-12hr  (1128) embryo 12-14hr  (1137) embryo 14-16hr  (1387) embryo 16-18hr  (1310) embryo 18-20hr  (1137) embryo 20-22hr  (1617) embryo 22-24hr  (1625) larva L1  (951) larva L2  (889) larva L3 12hr old  (939) larva L3 puffstage 1-2  (1069) larva L3 puffstage 3-6  (1345) larva L3 puffstage 7-9  (1560) white prepupae new  (1603) white prepupae 12hr  (3427) white prepupae 24hr  (3122) pupae 2d postWPP  (2400) pupae 3d postWPP  (1902) pupae 4d postWPP  (1413) adult male 01day  (1672) adult male 05day  (2274) adult male 30day  (2260) adult female 01day  (1377) adult female 05day  (1788) adult female 30day  (1803) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2727) embryo 02-04hr  (2522) embryo 04-06hr  (1836) embryo 06-08hr  (1689) embryo 08-10hr  (1675) embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr  (1617) embryo 22-24hr  (1625) larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9  (1560) white prepupae new  (1603) white prepupae 12hr  (3427) white prepupae 24hr  (3122) pupae 2d postWPP  (2400) pupae 3d postWPP  (1902) pupae 4d postWPP  1413 adult male 01day  (1672) adult male 05day  (2274) adult male 30day  (2260) adult female 01day    1377 adult female 05day  (1788) adult female 30day  (1803) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2727 embryo 02-04hr    2522 embryo 04-06hr    1836 embryo 06-08hr    1689 embryo 08-10hr    1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr    1617 embryo 22-24hr    1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9    1560 white prepupae new    1603 white prepupae 12hr    3427 white prepupae 24hr    3122 pupae 2d postWPP    2400 pupae 3d postWPP    1902 pupae 4d postWPP    1413 adult male 01day    1672 adult male 05day    2274 adult male 30day    2260 adult female 01day    1377 adult female 05day    1788 adult female 30day    1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2727 embryo 02-04hr    2522 embryo 04-06hr    1836 embryo 06-08hr    1689 embryo 08-10hr    1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr    1617 embryo 22-24hr    1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9    1560 white prepupae new    1603 white prepupae 12hr    3427 white prepupae 24hr    3122 pupae 2d postWPP    2400 pupae 3d postWPP    1902 pupae 4d postWPP    1413 adult male 01day    1672 adult male 05day    2274 adult male 30day    2260 adult female 01day    1377 adult female 05day    1788 adult female 30day    1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036020 expression level Developmental Stage   Expression Level embryo 00-02hr    2727 embryo 02-04hr    2522 embryo 04-06hr    1836 embryo 06-08hr    1689 embryo 08-10hr    1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr    1617 embryo 22-24hr    1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9    1560 white prepupae new    1603 white prepupae 12hr    3427 white prepupae 24hr    3122 pupae 2d postWPP    2400 pupae 3d postWPP    1902 pupae 4d postWPP    1413 adult male 01day    1672 adult male 05day    2274 adult male 30day    2260 adult female 01day    1377 adult female 05day    1788 adult female 30day    1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2727) embryo 02-04hr  (2522) embryo 04-06hr  (1836) embryo 06-08hr  (1689) embryo 08-10hr  (1675) embryo 10-12hr  (1128) embryo 12-14hr  (1137) embryo 14-16hr  (1387) embryo 16-18hr  (1310) embryo 18-20hr  (1137) embryo 20-22hr  (1617) embryo 22-24hr  (1625) larva L1  (951) larva L2  (889) larva L3 12hr old  (939) larva L3 puffstage 1-2  (1069) larva L3 puffstage 3-6  (1345) larva L3 puffstage 7-9  (1560) white prepupae new  (1603) white prepupae 12hr  (3427) white prepupae 24hr  (3122) pupae 2d postWPP  (2400) pupae 3d postWPP  (1902) pupae 4d postWPP  (1413) adult male 01day  (1672) adult male 05day  (2274) adult male 30day  (2260) adult female 01day  (1377) adult female 05day  (1788) adult female 30day  (1803) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2727) embryo 02-04hr  (2522) embryo 04-06hr  1836 embryo 06-08hr  1689 embryo 08-10hr  1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr  1617 embryo 22-24hr  1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9  1560 white prepupae new  1603 white prepupae 12hr  (3427) white prepupae 24hr  (3122) pupae 2d postWPP  2400 pupae 3d postWPP  1902 pupae 4d postWPP  1413 adult male 01day  1672 adult male 05day  2274 adult male 30day  2260 adult female 01day    1377 adult female 05day  1788 adult female 30day  1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2727 embryo 02-04hr    2522 embryo 04-06hr    1836 embryo 06-08hr    1689 embryo 08-10hr    1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr    1617 embryo 22-24hr    1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9    1560 white prepupae new    1603 white prepupae 12hr    3427 white prepupae 24hr    3122 pupae 2d postWPP    2400 pupae 3d postWPP    1902 pupae 4d postWPP    1413 adult male 01day    1672 adult male 05day    2274 adult male 30day    2260 adult female 01day    1377 adult female 05day    1788 adult female 30day    1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2727 embryo 02-04hr    2522 embryo 04-06hr    1836 embryo 06-08hr    1689 embryo 08-10hr    1675 embryo 10-12hr    1128 embryo 12-14hr    1137 embryo 14-16hr    1387 embryo 16-18hr    1310 embryo 18-20hr    1137 embryo 20-22hr    1617 embryo 22-24hr    1625 larva L1    951 larva L2    889 larva L3 12hr old    939 larva L3 puffstage 1-2    1069 larva L3 puffstage 3-6    1345 larva L3 puffstage 7-9    1560 white prepupae new    1603 white prepupae 12hr    3427 white prepupae 24hr    3122 pupae 2d postWPP    2400 pupae 3d postWPP    1902 pupae 4d postWPP    1413 adult male 01day    1672 adult male 05day    2274 adult male 30day    2260 adult female 01day    1377 adult female 05day    1788 adult female 30day    1803 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036020    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036020 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult hindgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult ovary, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036020 expression level Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036020 expression level Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    128.225 Larval Midgut    58.7 Larval Hindgut    110.9 Larval Malpighian Tubules    168.8 Larval Fat Body    103.1 Larval Salivary Gland    142.6 Larval Trachea    101.125 Larval Carcass    75.625 Adult Head    58.9 Adult Eye    93.4 Adult Brain    103 Adult Thoracic-Abdominal Ganglion    93.7 Adult Crop    179.9 Adult Midgut    77.6 Adult Hindgut    117.9 Adult Malpighian Tubules    173.9 Adult Fat Body    85.3 Adult Salivary Gland    146.1 Adult Heart    74.275 Adult VirginFemale Spermatheca    50.1 Adult InseminatedFemale Spermatheca    39.9 Adult Ovary    171 Adult Testis    387.6 Adult Male Accessory Gland    96.5 Adult Carcass    77.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    58.9   NA  Eye    93.4   NA  Brain    103   128.225  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    93.7   NA  Crop    179.9   58.7  Midgut    77.6   110.9  Hindgut    117.9   168.8  Malpighian Tubules    173.9   103.1  Fat Body    85.3   142.6  Salivary Gland    146.1   NA  Heart    74.275   101.125  Trachea    NA   NA  VirginFemale Spermatheca    50.1   NA  InseminatedFemale Spermatheca    39.9   NA  Ovary    171   NA  Testis    387.6   NA  Male Accessory Gland    96.5   75.625  Carcass    77.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_27
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036020 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8336-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG8336 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG8336GD13759 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG8336 Class Mutagen Stocks Known lesion CG8336MB04909 1 -- CG8336NP4480 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG8336 Class Mutagen Stocks Known lesion CG8336GD13759 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel6114 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13759} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Or67bMB04909 No P{GawB}CG8336NP4480 No
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
binding inferred from electronic annotation with InterPro:IPR011990 (FlyBase Curators et al., 2004-) peptidyl-prolyl cis-trans isomerase activity inferred from electronic annotation with InterPro:IPR002130 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
protein folding inferred from electronic annotation with InterPro:IPR002130 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG8336 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036020 DroID - A comprehensive database of gene and protein interactions. • FBgn0036020 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39121
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25145 Dere\GG15394 Dgri\GH16309 Dmoj\GI13253 Dper\GL12709 Dpse\GA20999 Dsec\GM25168 Dsim\GD14199 Dvir\GJ12024 Dwil\GK16621 Dyak\GE20859
Curated drosophilid orthologs	Dpse\GA20999
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000013-PA Aedes aegypti (mosquito) AGAP003265-PA Anopheles gambiae (mosquito) At2g15790.1 Arabidopsis thaliana (wall cress) 37516 Batrachochytrium dendrobatidis (chytrid fungus) 123289 Branchiostoma floridae (lancelet) 128707 Branchiostoma floridae (lancelet) BGIBMGA009341-PA Bombyx mori (silk worm) ENSBTAP00000022180 Bos taurus (bovine) CAL0000916 Candida albicans (a form of yeast) ENSCAFP00000012766 Canis familiaris (dog) cn06430 Cryptococcus neoformans (yeast-like fungus) CPIJ016592 Culex pipens (mosquito) ENSCPOP00000000943 Cavia porcellus (guinea pig) 136386 Chlamidomonas reinhardtii (green alga) 170435 Capitella spl (polychaete worm) DDB0235299 Dictyostelium discoideum (amoeba) DEHA2A13640g Debaryomyces Hansenii (yeast) ENSDARP00000056712 Danio rerio (zebra fish) ENSECAP00000008852 Equus caballus (horse) ENSGACP00000021943 Gymnopilus aculeatus (mushroom) ENSGALP00000015366 Gallus gallus (chicken) ENSP00000303754 Homo sapiens (human) KLLA0F05093g Kluyveromyces lactis (yeast) 112989 Lottia gigantea (owl limpet) LmjF35.4770 Leishmania major (virus) ENSMMUP00000023369 Macaca mulatta (rhesus monkey) ENSMMUP00000027013 Macaca mulatta (rhesus monkey) ENSMMUP00000041127 Macaca mulatta (rhesus monkey) ENSMUSP00000029382 Mus musculus (house mouse) 103092 Nematostella vectensis (starlet anemone) XP_001603058.1 Nasonia vitripennis (wasp) ENSOANP00000023571 Ornithorynchus anatinus (platypus) ENSORLP00000025064 Oryzias latipes (japanese killifish) LOC_Os06g11320.1 Oryza sativa (asian rice) PHUM000691-PA Pediculus humanus (human body louse) 208358 Physcomitrella patens (moss) ENSPPYP00000016942 Pongo pygmaeus (orangutan) 137076 Phytophthora sojae (root rot pathogen) 801111 Populus trichocarpa (black cottonwood) ENSPTRP00000028417 Pan troglodytes (chimpanzee) PVX_093595 Plasmodium vivax (protozoal parasite) ENSRNOP00000035797 Rattus norvegicus (norway rat) ENSRNOP00000053097 Rattus norvegicus (norway rat) 5010702 Sorghum bicolor (sorghum) YLR216C Saccharomyces cerevisiae (budding yeast) SPAC1B3.03c Schizosaccharomyces pombe (fission yeast) XP_001194141.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201326.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968746.1 Tribolium castaneum (red flour beetle) Tc00.1047053503687.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506885.400 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016019 Tetraodon nigroviridis (green spotted pufferfish) TP03_0222 Theileria parva (parasitic protozoan) ENSTRUP00000041431 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042209 Xenopus tropicalis (frog) YALI0C16775g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12975 NV16998 ISCW014907 FBgn0238149 FBgn0218623 FBgn0199276 FBgn0185885 FBgn0180028 FBgn0080988 FBgn0150315 FBgn0136010 FBgn0123780 FBgn0107645 FBgn0102137 CPIJ016592 BGIBMGA009341 ACYPI53623 GB10578 AGAP003265 AAEL000013 PHUM474930 GLEAN_07008
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	24728 w1118; Mi{ET1}Or67bMB04909 CG8336MB04909
Kyoto	104692 y* w*; P{GawB}CG8336NP4480 / TM6, P{UAS-lacZ.UW23-1}UW23-1
VDRC	v23729 w1118; P{GD13759}v23729
Genomic Clones ( 2 )
	BACR02B01 BACR12K04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06403
Other clones	DPiM_GH06403
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03932 AT04719 AT07162 AT09301 AT13143 GH12882 GH20344 LD04787 LD11271 RE51872 RE64420 RE65338
Other clones	AT16219 bs33f02 CK01.16B.E10 EK098534 EK308749 EP08729 RP004027662 RP004098718 RP004204483 RP004209231 RP004211302 RP004247554 RP004304375 RP004363667 RP004450978 RP004513220 RP004528120
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036020 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39121
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140081 NM_168354 NM_168355 RefSeq (Proteins) • NP_648338 NP_729517 NP_729518 DDBJ / EMBL / GenBank • AAF50235 AAL13532 AAN11947 AAN11948 AI107102 AI389222 AI402046 AI946971 AY058303 Entrez Gene - A searchable database of RefSeq genes. • 39121 UniProtKB/TrEMBL • Q9VT21
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidyl-prolyl cis-trans isomerase, cyclophilin-type (IPR002130) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Cyclophilin-like (IPR015891) Tetratricopeptide repeat (IPR019734) Tetratricopeptide TPR-1 (IPR001440)
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036020 DroID - A comprehensive database of gene and protein interactions. • FBgn0036020 DRSC - Results from RNAi screens. • FBgn0036020 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036020 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8336-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036020 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39121 InParanoid A subset of ortholog calls from InParanoid. • AAEL000013-PA Aedes aegypti (mosquito) AGAP003265-PA Anopheles gambiae (mosquito) At2g15790.1 Arabidopsis thaliana (wall cress) 37516 Batrachochytrium dendrobatidis (chytrid fungus) 123289 Branchiostoma floridae (lancelet) 128707 Branchiostoma floridae (lancelet) BGIBMGA009341-PA Bombyx mori (silk worm) ENSBTAP00000022180 Bos taurus (bovine) CAL0000916 Candida albicans (a form of yeast) ENSCAFP00000012766 Canis familiaris (dog) cn06430 Cryptococcus neoformans (yeast-like fungus) CPIJ016592 Culex pipens (mosquito) ENSCPOP00000000943 Cavia porcellus (guinea pig) 136386 Chlamidomonas reinhardtii (green alga) 170435 Capitella spl (polychaete worm) DDB0235299 Dictyostelium discoideum (amoeba) DEHA2A13640g Debaryomyces Hansenii (yeast) ENSDARP00000056712 Danio rerio (zebra fish) ENSECAP00000008852 Equus caballus (horse) ENSGACP00000021943 Gymnopilus aculeatus (mushroom) ENSGALP00000015366 Gallus gallus (chicken) ENSP00000303754 Homo sapiens (human) KLLA0F05093g Kluyveromyces lactis (yeast) 112989 Lottia gigantea (owl limpet) LmjF35.4770 Leishmania major (virus) ENSMMUP00000023369 Macaca mulatta (rhesus monkey) ENSMMUP00000027013 Macaca mulatta (rhesus monkey) ENSMMUP00000041127 Macaca mulatta (rhesus monkey) ENSMUSP00000029382 Mus musculus (house mouse) 103092 Nematostella vectensis (starlet anemone) XP_001603058.1 Nasonia vitripennis (wasp) ENSOANP00000023571 Ornithorynchus anatinus (platypus) ENSORLP00000025064 Oryzias latipes (japanese killifish) LOC_Os06g11320.1 Oryza sativa (asian rice) PHUM000691-PA Pediculus humanus (human body louse) 208358 Physcomitrella patens (moss) ENSPPYP00000016942 Pongo pygmaeus (orangutan) 137076 Phytophthora sojae (root rot pathogen) 801111 Populus trichocarpa (black cottonwood) ENSPTRP00000028417 Pan troglodytes (chimpanzee) PVX_093595 Plasmodium vivax (protozoal parasite) ENSRNOP00000035797 Rattus norvegicus (norway rat) ENSRNOP00000053097 Rattus norvegicus (norway rat) 5010702 Sorghum bicolor (sorghum) YLR216C Saccharomyces cerevisiae (budding yeast) SPAC1B3.03c Schizosaccharomyces pombe (fission yeast) XP_001194141.1 Strongylocentrotus purpuratus (purple sea urchin) XP_001201326.1 Strongylocentrotus purpuratus (purple sea urchin) XP_968746.1 Tribolium castaneum (red flour beetle) Tc00.1047053503687.40 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506885.400 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000016019 Tetraodon nigroviridis (green spotted pufferfish) TP03_0222 Theileria parva (parasitic protozoan) ENSTRUP00000041431 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000042209 Xenopus tropicalis (frog) YALI0C16775g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39121 modMine - Data generated by the modENCODE project. • FBgn0036020 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12975 NV16998 ISCW014907 FBgn0238149 FBgn0218623 FBgn0199276 FBgn0185885 FBgn0180028 FBgn0080988 FBgn0150315 FBgn0136010 FBgn0123780 FBgn0107645 FBgn0102137 CPIJ016592 BGIBMGA009341 ACYPI53623 GB10578 AGAP003265 AAEL000013 PHUM474930 GLEAN_07008
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG8336 (Telonis-Scott et al., 2009)
Name Synonym
Secondary FlyBase IDs
References ( 11 )
Research paper	Telonis-Scott et al., 2009, J. Insect Physiol. 55(6): 549--555 Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. [FBrf0208060]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	BDGP TI submission, 2007.10.30, batch763.xml batch763.xml [FBrf0200261] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Ryder, 2004.4.26, Exelixis CG deletion data. Exelixis CG deletion data. [FBrf0184335] Oliver, 2001.8.16, File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). File from B. Oliver containing information on ESTs expressed in the Drosophila testis, described in Andrews et al., 2000, Genome Res. 10(12): 2030-2043 (FBrf0132348). [FBrf0137492]
FlyBase analysis	FlyBase Curators, 2008, Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. Insertion identifiers and alleles based on genomic location of insertions with respect to gene annotations. [FBrf0202955]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]