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Gene Dmel\Ilp2

General Information
Symbol	Dmel\Ilp2	Species	D. melanogaster
Name	Insulin-like peptide 2	Annotation symbol	CG8167
Feature type	protein_coding_gene	FlyBase ID	FBgn0036046
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	Dilp2, DILP, dILP-2, Ilp-2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C8-67C8	Sequence location	3L:9,792,798..9,793,540 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Insulin-like peptide 2 is referred to in FlyBase by the symbol Dmel\Ilp2 (CG8167, FBgn0036046). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: insulin receptor binding. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; regulation of growth; regulation of multicellular organismal process; positive regulation of biological process; homeostatic process; cellular component organization or biogenesis; larval feeding behavior; determination of adult lifespan; carbohydrate utilization; multi-organism reproductive process. 11 alleles are reported. The phenotype of these alleles is annotated with: wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Insulin family; Insulin, conserved site; Insulin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1629220_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ilp2. Gene sequence location is 3L:9792798..9793540.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C8-67C8   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ilp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43 Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ilp2-RA FBtr0076329  NM_079288   670   137
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ilp2-PA   FBpp0076058   15.3   137   7.05     NP_524012   AAF50204
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like (IPR016179) Insulin family (IPR022352) Insulin, conserved site (IPR022353)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50204   AI134194   AJ291726 CAC17605   AW940415   AY069095 AAL39240
UniProtKB/Swiss-Prot	Q9VT51
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 16   embryonic/larval midgut   (Brogiolo et al., 2001) mesoderm   (Brogiolo et al., 2001) second instar larval stage -- third instar larval stage   dorsomedial neurosecretory cell of pars intercerebralis   (Ikeya et al., 2002) third instar larval stage   embryonic/larval brain | anterior & medial & restricted   (Brogiolo et al., 2001) imaginal disc | ubiquitous   (Brogiolo et al., 2001) embryonic/larval salivary gland | ubiquitous   (Brogiolo et al., 2001) adult stage   dorsomedial neurosecretory cell   (Broughton et al., 2005)
Additional Descriptive Data
	Transcript is detected in the embryo with low levels in the embryonic mesoderm and high signal in the midgut. During the third larval instar transcript is ubiquitously expressed in imaginal discs at a low level and a high signal is detected in seven cells in each brain hemisphere in an anterior-medial postion (Brogiolo et al., 2001) Ilp2 is expressed in a bilaterally symmetrical cluster of 5 to 7 neurosecretory cells in the pars intercerebralis. It is co-expressed with Ilp3 and Ilp5. (Broughton et al., 2005) Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the first through third larval instars. (Ikeya et al., 2002)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   adult dorsomedial neurosecretory cell | subset   (Enell et al., 2010) adult pars intercerebralis   (Enell et al., 2010)
Additional Descriptive Data
	Ilp2 protein is expressed in the insulin producing cells (IPC), a subset of the dorsomedial neurosecretory cells of the pars intercerebralis and in other dorsal cells of this cluster. The IPC cells that express Ilp2 are also labeled by the expression of Scer\GAL4GABA-B-R2.PR. (Enell et al., 2010)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{Ilp2-GAL4.R} Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   neurosecretory cell   (Colombani et al., 2003) brain | restricted   (Rulifson et al., 2002, Rulifson et al., 2002) neurosecretory neuron of brain | subset   (Rulifson et al., 2002, Rulifson et al., 2002) neurosecretory neuron | subset   (Rulifson et al., 2002, Rulifson et al., 2002) adult stage   neuron | subset   (Agrawal et al., 2010) adult pars intercerebralis   (Jansen et al., 2009) adult pars intercerebralis | restricted   (Crocker et al., 2010) adult dorsomedial neurosecretory cell | subset   (Crocker et al., 2010)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye    19 Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (638.25) Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head  506.9 Adult Eye    19 Adult Brain  (1607.8) Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye    19 Adult Brain  (1607.8) Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye    19 Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye    19 Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head  506.9 Adult Eye    19 Adult Brain  (1607.8) Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye    19 Adult Brain  1607.8 Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye    19 Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion    18.1 Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body    11.4 Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca    11.6 Adult InseminatedFemale Spermatheca    13.6 Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    506.9   NA  Eye    no informative data   NA  Brain    1607.8   638.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    5.3   2.1  Midgut    3.7   2.1  Hindgut    7   1.7  Malpighian Tubules    4.2   2.5  Fat Body    no informative data   7.8  Salivary Gland    8   NA  Heart    3.1   3.85  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.7   NA  Testis    2.5   NA  Male Accessory Gland    5.4   2.625  Carcass    4.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female    51 head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female    35 head, mated 1-day male    17 head, mated 4-day male    37 head, mated 20-day male    78 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female  (51) head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female  (35) head, mated 1-day male    17 head, mated 4-day male  (37) head, mated 20-day male  (78) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female    51 head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female    35 head, mated 1-day male    17 head, mated 4-day male    37 head, mated 20-day male    78 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female    51 head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female    35 head, mated 1-day male    17 head, mated 4-day male    37 head, mated 20-day male    78 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female    51 head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female    35 head, mated 1-day male    17 head, mated 4-day male    37 head, mated 20-day male    78 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female  (51) head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female  (35) head, mated 1-day male    17 head, mated 4-day male  (37) head, mated 20-day male  (78) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female    51 head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female    35 head, mated 1-day male    17 head, mated 4-day male    37 head, mated 20-day male    78 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    19 central nervous system, pupae P8    0 head, virgin 1-day female    12 head, virgin 4-day female    18 head, virgin 20-day female    51 head, mated 1-day female    11 head, mated 4-day female    25 head, mated 20-day female    35 head, mated 1-day male    17 head, mated 4-day male    37 head, mated 20-day male    78 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    3 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    1 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1  (29) larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1  29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    0 embryo 18-20hr    3 embryo 20-22hr    12 embryo 22-24hr    16 larva L1    29 larva L2    24 larva L3 12hr old    11 larva L3 puffstage 1-2    8 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    4 white prepupae new    2 white prepupae 12hr    1 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    1 pupae 4d postWPP    4 adult male 01day    10 adult male 05day    12 adult male 30day    18 adult female 01day    5 adult female 05day    4 adult female 30day    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    1 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    2 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    2 Ethanol 5% 3 hrs, larvae L3    4 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_16 mE1_20_mRNA_expression_cluster_17
External Data & Images
Linkouts	BDGP expression data • GH11579 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036046 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8167-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PP Ilp2Scer\UAS.cBa lethal, with Scer\GAL4ppl.PP Ilp2Scer\UAS.cBa viable Ilp21 viable, with Scer\GAL4pnr-MD237 Ilp2GD15756 Other Phenotypes Allele developmental rate defective Ilp21 increased cell number, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa increased cell size, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa large body Ilp2Scer\UAS.cBa large body, with Scer\GAL4arm.PS Ilp2Scer\UAS.cBa large body, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa long lived Ilp21 mating defective Ilp21 short lived | nutrition conditional, with Scer\GAL4Ilp2.PW Ilp2Scer\UAS.cBa size defective, with Scer\GAL4sd-SG29.1 Ilp2Scer\UAS.cBa small body, with Scer\GAL4Ilp2.PR Ilp2GD15756 stress response defective, with Scer\GAL4Ilp2.PR Ilp2Scer\UAS.cBa visible, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa Phenotype manifest in Allele wing, with Scer\GAL4sd-SG29.1 Ilp2Scer\UAS.cBa
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ilp2 Class Mutagen Stocks Known lesion Ilp21 SCEI endonuclease FLPase ends-out gene targeting 1 Yes
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ilp2 Class Mutagen Stocks Known lesion Ilp2GD15756 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ilp2HMS00476 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp2hs.PR in vitro construct - regulatory fusion 1 Yes Ilp2JF01518 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp2KK110961 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp2Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes Ilp2Scer\UAS.cZa in vitro construct - regulatory fusion 0 Yes Ilp2Scer\UAS.T:Avic\GFP-EMD in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ilp2Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ilp2w.Scer\SceI.RS in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AC1 (Brogiolo et al., 2001) Df(3L)Ilp1-4 (Grönke et al., 2010) Df(3L)Ilp1-5 (Zhang et al., 2009) Df(3L)Ilp2-3 (Grönke et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15756} NA P{KK110961} NA P{TRiP.HMS00476} NA P{TRiP.JF01518} NA P{UAS-Ilp2.FLAG} NA P{UAS-Ilp2-EMD} NA GAL4 construct P{Ilp2-GAL4.W} No P{Ilp2-Switch.K} No characterization construct P{Ilp2-GAL4.215-3} NA P{Ilp2-GAL4.215-55} NA P{Ilp2-GAL4.R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
carbohydrate utilization inferred from mutant phenotype (Zhang et al., 2009) determination of adult lifespan inferred from mutant phenotype (Grönke et al., 2010) female mating behavior inferred from mutant phenotype (Wigby et al., 2011) germ-line stem-cell niche homeostasis inferred from mutant phenotype (Hsu and Drummond-Barbosa, 2009) insulin receptor signaling pathway inferred from genetic interaction with InR (Brogiolo et al., 2001) larval feeding behavior inferred from mutant phenotype (Wu et al., 2005) positive regulation of cell growth inferred from mutant phenotype (Zhang et al., 2009) positive regulation of multicellular organism growth inferred from mutant phenotype (Zhang et al., 2009) regulation of cell size inferred from mutant phenotype (Brogiolo et al., 2001) regulation of growth rate inferred from mutant phenotype (Grönke et al., 2010) regulation of multicellular organism growth inferred from mutant phenotype (Brogiolo et al., 2001) triglyceride homeostasis inferred from mutant phenotype (Zhang et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
hormone activity inferred from electronic annotation with InterPro:IPR016179 (FlyBase Curators et al., 2004-) non-traceable author statement (van den Broeck, 2000.11.27) insulin receptor binding inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001)
Biological Process
CV term Evidence References
growth traceable author statement (Johnston and Gallant, 2002) insulin receptor signaling pathway inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001) traceable author statement (Johnston and Gallant, 2002) positive regulation of multicellular organism growth traceable author statement (Claeys et al., 2002, Johnston and Gallant, 2002)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Ilp2 - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - CG11656 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ilp2 - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - CG31200 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Ilp2 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - ImpL2 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Ilp2 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - Sec13 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Ilp2 - rdhB experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ilp2 allele Gene References Ilp2hs.PR rpr (Rulifson et al., 2002, Rulifson et al., 2002) Ilp2Scer\UAS.cBa InR (Brogiolo et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64538 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036046 DroID - A comprehensive database of gene and protein interactions. • FBgn0036046 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39150 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VT51
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W0Z0T Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6J105S Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6W0Z0T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ilp2     Drosophila simulans   Dsim\GD14218 Y   Drosophila sechellia   Dsec\GM25186 Y   Drosophila erecta   Dere\GG19126     Drosophila erecta   Dere\GG15413 Y   Drosophila yakuba   Dyak\GE21720 Y   Drosophila ananassae   Dana\GF24678 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA20861 Y   Drosophila willistoni   Dwil\GK10990 Y   Drosophila virilis   Dvir\GJ12130 Y   Drosophila mojavensis   Dmoj\GI13035 Y   Drosophila grimshawi   Dgri\GH15432 Y   Drosophila grimshawi   Dgri\GH15434
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6J105S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB43560   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009122   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22304   Atta cephalotes Leafcutter ant  Acep\ACEP24387   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14544   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19407   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18404   Linepithema humile Argentine ant  Lhum\LH15531   Pogonomyrmex barbatus Red harvester ant  Pbar\PB25489   Solenopsis invicta Red fire ant  Sinv\SINV14440   Acyrthosiphon pisum Pea aphid  Apim\ACYPI53158   Bombyx mori Silkmoth  Bmor\BBXG1   Bombyx mori Silkmoth  Bmor\BBXC1   Bombyx mori Silkmoth  Bmor\BBXA3   Bombyx mori Silkmoth  Bmor\BGIBMGA014496   Bombyx mori Silkmoth  Bmor\BGIBMGA011929   Bombyx mori Silkmoth  Bmor\Bmo.10600   Tribolium castaneum Red flour beetle  Tcas\GLEAN_07035
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD14218 Drosophila sechellia Dsec\GM25186 Drosophila erecta Dere\GG15413 Drosophila yakuba Dyak\GE21720 Drosophila ananassae Dana\GF24678 Drosophila pseudoobscura pseudoobscura Dpse\GA20861 Drosophila willistoni Dwil\GK10990 Drosophila virilis Dvir\GJ12130 Drosophila mojavensis Dmoj\GI13035 Drosophila grimshawi Dgri\GH15432
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	30881 w1118; Ilp21 37472 w*; P{hs-Ilp2.R}2/CyO 31068 y1 v1; P{TRiP.JF01518}attP2 32475 y1 sc* v1; P{TRiP.HMS00476}attP2/TM3, Sb1
VDRC	v102158 P{KK110961}VIE-260B v44760 w1118; P{GD15756}v44760/CyO v44761 w1118; P{GD15756}v44761/CyO
Genomic Clones ( 2 )
	BACR07A05 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11579
Other clones	DPiM_GH11579
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036046 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39150
Antibody Information
	polyclonal (Géminard et al., 2009, Veenstra et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079288 RefSeq (Proteins) • NP_524012 DDBJ / EMBL / GenBank • AAF50204 AAL39240 AI134194 AJ291726 AW940415 AY069095 CAC17605 Entrez Gene - A searchable database of RefSeq genes. • 39150 UniProtKB/Swiss-Prot • Q9VT51
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like (IPR016179) Insulin family (IPR022352) Insulin, conserved site (IPR022353) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH11579
Linkouts
	BioGRID - A database of protein and genetic interactions • 64538 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036046 DroID - A comprehensive database of gene and protein interactions. • FBgn0036046 DRSC - Results from RNAi screens. • FBgn0036046 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036046 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8167-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036046 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39150 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/dilp2.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39150 modMine - Data generated by the modENCODE project. • FBgn0036046 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q9VT51
Synonyms & Secondary IDs ( 28 )
Reported As
Symbol Synonym	CG8167 (Borras et al., 2003, Brogiolo et al., 2001, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1, Kim and Marqués, 2010) DILP (Wu et al., 2005, Nijhout, 2003, Drummond-Barbosa and Spradling, 2004, Nijhout, 2003, Cao and Brown, 2001) dilp (Belawat and Hafen, 2005) Dilp (Bradley and Leevers, 2003, Rhea et al., 2007) Dilp2 (Wong et al., 2012, LaFever and Drummond-Barbosa, 2005, Clements et al., 2003, Arquier et al., 2007, Crocker et al., 2010, Honegger et al., 2008, Rajan and Perrimon, 2012, Hsu and Drummond-Barbosa, 2008, Géminard et al., 2009, Söderberg et al., 2011, Enell et al., 2010, Wang et al., 2007, Cardona et al., 2009, Birse et al., 2011, Lee et al., 2008, Wang et al., 2009, Lee et al., 2009, Arquier et al., 2008, Agrawal et al., 2009, Delanoue et al., 2010, Birse et al., 2010, Demontis and Perrimon, 2010, Tsuda et al., 2010, Okamoto et al., 2013, Luo et al., 2012) dILP-2 (Teleman and Cohen, 2006) dilp2 (Wang et al., 2005, Broughton et al., 2005, Li and White, 2003, Rhea et al., 2005, Cypser and Tatar, 2004, Tatar et al., 2003, Ikeya et al., 2002, Rulifson et al., 2002, Rulifson et al., 2002, Ikeya and Hafen, 2002, Brogiolo et al., 2001, Min et al., 2007, Flatt et al., 2005, Libert, 2007, Karpac et al., 2009, Mattaliano et al., 2007, Belgacem and Martin, 2006, Melcher and Pankratz, 2005, Slack et al., 2010, Corl et al., 2005, Wu et al., 2005, Haselton et al., 2010, Tsuda et al., 2010, Guirao-Rico and Aguadé, 2011, Fridell et al., 2009, Slack et al., 2011, Kréneisz et al., 2010, Sheldon et al., 2011, Karpac et al., 2011, Flatt et al., 2008, Broughton et al., 2008, Kaplan et al., 2008, Hsu and Drummond-Barbosa, 2009, Amcheslavsky et al., 2009, Humphrey et al., 2009, Walkiewicz and Stern, 2009, Kaplan et al., 2008, Buch et al., 2008, Okamoto et al., 2009, Clements et al., 2008, Hull-Thompson et al., 2009, Giannakou et al., 2007, Nielsen et al., 2008, Zhang et al., 2009, Nässel et al., 2008, Wessells et al., 2009, Grönke et al., 2010, Ballard et al., 2010, Maynard et al., 2010, De Luca et al., 2010, Kahsai et al., 2010, Sekine et al., 2010, Wigby et al., 2011, Honegger et al., 2008, Alic et al., 2011, Wang et al., 2008, McClure et al., 2011, Park et al., 2011, Rideout et al., 2012, Marshall et al., 2012, Yu et al., 2012) DILP2 (Li and White, 2003, Bender et al., 2004, Rayburn et al., 2004, Leevers, 2001, Musselman et al., 2011, Luong et al., 2006, Slaidina et al., 2009, Luo et al., 2012) dilp-2 (Hwangbo et al., 2004, Tountas and Fortini, 2007) dILP2 (Saucedo and Edgar, 2002, Park et al., 2008, Bauer et al., 2010, Wang et al., 2011, Bauer et al., 2007, Teleman et al., 2008, Chell and Brand, 2010, Jansen et al., 2009, Killip and Grewal, 2012) Dilp 2 (Claeys et al., 2002) Dilp-2 (Hoshizaki and Gibbs, 2007) dIlp2 (Hewes et al., 2006, Boyd et al., 2011, Thomas et al., 2012) Ilp (Edgar, 2006) ILP2 (Mellerick et al., 2003, Hahn et al., 2010) Ilp2 (Wang et al., 2011, Seugnet et al., 2009, Veenstra et al., 2008, Sousa-Nunes et al., 2011, Cognigni et al., 2011, Thomas et al., 2012) ilp2 (Song et al., 2010, Veenstra, 2009, Min et al., 2008, Varghese et al., 2010, Wang et al., 2008, Kim et al., 2008) Ilp-2 (Veenstra et al., 2008, Pospisilik et al., 2010) IRP   unnamed (vanden Broeck, 2001)
Name Synonym	Drosophila insulin-like peptide 2 (Oldham and Hafen, 2003) Drosophila insulin like peptide 2 (Crocker et al., 2010) insulin-like peptide (Flatt et al., 2005, Lee et al., 2009) insulin-like peptide 2 (Brogiolo et al., 2001, Honegger et al., 2008, Veenstra, 2009, Arquier et al., 2008, Ballard et al., 2010, Tsuda et al., 2010) Insulin-like peptide 2   insulin-like peptide-2 (Min et al., 2008) Insulin-related peptide (van den Broeck, 2000.11.27) Insulin- related peptide 2 (Kim and Marqués, 2010)
Secondary FlyBase IDs
	FBgn0044432
References ( 165 )
Generate a list of	All references relating to this gene ( 165 )
List References by type	Research paper  ( 117 ) Supplementary material  ( 6 ) Review  ( 14 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 13 ) FlyBase analysis  ( 1 ) Conference report  ( 3 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 33 )
	Boulan et al., 2013, Curr. Biol. 23(6): 473--478 bantam miRNA Promotes Systemic Growth by Connecting Insulin Signaling and Ecdysone Production. [FBrf0221079] Okamoto et al., 2013, Genes Dev. 27(1): 87--97 A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. [FBrf0220509] Erion et al., 2012, J. Biol. Chem. 287(39): 32406--32414 Interaction between Sleep and Metabolism in Drosophila with Altered Octopamine Signaling. [FBrf0219526] Killip and Grewal, 2012, Dev. Biol. 371(2): 191--202 DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway. [FBrf0219592] Luo et al., 2012, Cell. Molec. Life Sci. 69(3): 471--484 Insulin-producing cells in the brain of adult Drosophila are regulated by the serotonin 5-HT(1A) receptor. [FBrf0217219] Marshall et al., 2012, EMBO J. 31(8): 1916--1930 Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth in Drosophila. [FBrf0218035] Rajan and Perrimon, 2012, Cell 151(1): 123--137 Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. [FBrf0219535] Rideout et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(4): 1139--1144 Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling. [FBrf0217359] Shim et al., 2012, Nat. Cell Biol. 14(4): 394--400 Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila. [FBrf0217918] Stafford et al., 2012, J. Neurosci. 32(42): 14767--14774 Integration of taste and calorie sensing in Drosophila. [FBrf0219704] Thomas et al., 2012, PLoS ONE 7(7): e40276 A Versatile Method for Cell-Specific Profiling of Translated mRNAs in Drosophila. [FBrf0218903] Thomson et al., 2012, genesis 50(6): 453--465 Oocyte destruction is activated during viral infection. [FBrf0218617] Wong et al., 2012, Cell 148(5): 1029--1038 Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture. [FBrf0217647] Yu et al., 2012, Mol. Cell. Biol. 32(18): 3610--3623 Neuronal Cbl Controls Biosynthesis of Insulin-Like Peptides in Drosophila melanogaster. [FBrf0219284] Alic et al., 2011, Aging Cell 10(1): 137--147 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. [FBrf0212768] Birse et al., 2011, J. Exp. Biol. 214(24): 4201--4208 Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR. [FBrf0216793] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] Guirao-Rico and Aguadé, 2011, Mol. Biol. Evol. 28(5): 1557--1560 Molecular evolution of the ligands of the insulin-signaling pathway: dilp genes in the genus drosophila. [FBrf0214497] Karpac et al., 2011, Dev. Cell 20(6): 841--854 Dynamic coordination of innate immune signaling and insulin signaling regulates systemic responses to localized DNA damage. [FBrf0213873] McClure et al., 2011, Dis. Model Mech. 4(3): 335--346 A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. [FBrf0213698] Musselman et al., 2011, Dis. Model Mech. 4(6): 842--849 A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. [FBrf0216626] O'Brien et al., 2011, Cell 147(3): 603--614 Altered modes of stem cell division drive adaptive intestinal growth. [FBrf0216512] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Sheldon et al., 2011, PLoS ONE 6(8): e23343 SLOB, a SLOWPOKE Channel Binding Protein, Regulates Insulin Pathway Signaling and Metabolism in Drosophila. [FBrf0214706] Shin et al., 2011, Science 334(6056): 670--674 Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. [FBrf0216582] Slack et al., 2011, Aging Cell 10(5): 735--748 dFOXO-independent effects of reduced insulin-like signaling in Drosophila. [FBrf0215229] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Söderberg et al., 2011, PLoS ONE 6(5): e19866 Insulin Production and Signaling in Renal Tubules of Drosophila Is under Control of Tachykinin-Related Peptide and Regulates Stress Resistance. [FBrf0213657] Wang et al., 2011, Cell Cycle 10(16): 2628--2634 Regulation of adult stem cell behavior by nutrient signaling. [FBrf0214811] Wang et al., 2011, Cell 145(4): 596--606 A hormone-dependent module regulating energy balance. [FBrf0213699] Wigby et al., 2011, Proc. Biol. Sci. 278(1704): 424--431 Insulin signalling regulates remating in female Drosophila. [FBrf0212666] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...