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Gene Dmel\Ilp2

General Information
Symbol	Dmel\Ilp2	Species	D. melanogaster
Name	Insulin-like peptide 2	Annotation symbol	CG8167
Feature type	protein_coding_gene	FlyBase ID	FBgn0036046
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Dilp2, DILP, dILP-2, Ilp-2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C8-67C8	Sequence location	3L:9,792,798..9,793,540 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Insulin-like peptide 2 is referred to in FlyBase by the symbol Dmel\Ilp2 (CG8167, FBgn0036046). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: insulin receptor binding. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; regulation of growth; homeostatic process; regulation of multicellular organismal process; positive regulation of biological process; cellular component organization or biogenesis; larval feeding behavior; mating; determination of adult lifespan; carbohydrate utilization. 10 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Insulin family; Insulin, conserved site; Insulin-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1629220_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Ilp2. Gene sequence location is 3L:9792798..9793540.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Shin et al., 2011, Science 334(6056): 670--674 O'Brien et al., 2011, Cell 147(3): 603--614 Sequence features HFA10968 BKN30961
FB2011_10	References Park et al., 2011, PLoS Genet. 7(8): e1002241
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C8-67C8   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ilp2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.43
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ilp2-RA FBtr0076329  NM_079288   670   137
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ilp2-PA   FBpp0076058   15.3   137   7.05     NP_524012   AAF50204
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like (IPR016179) Insulin family (IPR022352) Insulin, conserved site (IPR022353)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50204   AI134194   AJ291726 CAC17605   AW940415   AY069095 AAL39240
UniProtKB/Swiss-Prot	Q9VT51
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 16   embryonic/larval midgut   (Brogiolo et al., 2001) mesoderm   (Brogiolo et al., 2001) second instar larval stage -- third instar larval stage   dorsomedial neurosecretory cell of pars intercerebralis   (Ikeya et al., 2002) third instar larval stage   embryonic/larval brain | anterior & medial & restricted   (Brogiolo et al., 2001) imaginal disc | ubiquitous   (Brogiolo et al., 2001) embryonic/larval salivary gland | ubiquitous   (Brogiolo et al., 2001)
Additional Descriptive Data
	Transcript is detected in the embryo with low levels in the embryonic mesoderm and high signal in the midgut. During the third larval instar transcript is ubiquitously expressed in imaginal discs at a low level and a high signal is detected in seven cells in each brain hemisphere in an anterior-medial postion (Brogiolo et al., 2001) Transcript is expressed in two clusters of cells in the pars intercerebralis corresponding to the medial neurosecretory cell clusters (m-NSCs) from the first through third larval instars. (Ikeya et al., 2002)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036046    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036046 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of no expression detected. Peak expression observed during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036046 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1    2218 larva L2    1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr  (257) embryo 20-22hr  (881) embryo 22-24hr  (1197) larva L1  (2218) larva L2  (1776) larva L3 12hr old  (812) larva L3 puffstage 1-2  (599) larva L3 puffstage 3-6  (364) larva L3 puffstage 7-9  (311) white prepupae new  (166) white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP  (318) adult male 01day  (740) adult male 05day  (914) adult male 30day  (1344) adult female 01day  (352) adult female 05day  (280) adult female 30day  (313) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1  (2218) larva L2  (1776) larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1    2218 larva L2    1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1    2218 larva L2    1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036046 expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1    2218 larva L2    1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr  (257) embryo 20-22hr  (881) embryo 22-24hr  (1197) larva L1  (2218) larva L2  (1776) larva L3 12hr old  (812) larva L3 puffstage 1-2  (599) larva L3 puffstage 3-6  (364) larva L3 puffstage 7-9  (311) white prepupae new  (166) white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP  (318) adult male 01day  (740) adult male 05day  (914) adult male 30day  (1344) adult female 01day  (352) adult female 05day  (280) adult female 30day  (313) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1  2218 larva L2  1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1    2218 larva L2    1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    5 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    2 embryo 10-12hr    0 embryo 12-14hr    2 embryo 14-16hr    9 embryo 16-18hr    18 embryo 18-20hr    257 embryo 20-22hr    881 embryo 22-24hr    1197 larva L1    2218 larva L2    1776 larva L3 12hr old    812 larva L3 puffstage 1-2    599 larva L3 puffstage 3-6    364 larva L3 puffstage 7-9    311 white prepupae new    166 white prepupae 12hr    90 white prepupae 24hr    34 pupae 2d postWPP    30 pupae 3d postWPP    73 pupae 4d postWPP    318 adult male 01day    740 adult male 05day    914 adult male 30day    1344 adult female 01day    352 adult female 05day    280 adult female 30day    313 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036046    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036046 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036046 expression level Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye no informative data Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (638.25) Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head  506.9 Adult Eye no informative data Adult Brain  (1607.8) Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye no informative data Adult Brain  (1607.8) Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye no informative data Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036046 expression level Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye no informative data Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head  506.9 Adult Eye no informative data Adult Brain  (1607.8) Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye no informative data Adult Brain  1607.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    638.25 Larval Midgut    2.1 Larval Hindgut    2.1 Larval Malpighian Tubules    1.7 Larval Fat Body    2.5 Larval Salivary Gland    7.8 Larval Trachea    3.85 Larval Carcass    2.625 Adult Head    506.9 Adult Eye no informative data Adult Brain    1607.8 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    5.3 Adult Midgut    3.7 Adult Hindgut    7 Adult Malpighian Tubules    4.2 Adult Fat Body no informative data Adult Salivary Gland    8 Adult Heart    3.1 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    0.7 Adult Testis    2.5 Adult Male Accessory Gland    5.4 Adult Carcass    4.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    506.9   NA  Eye    no informative data   NA  Brain    1607.8   638.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    5.3   2.1  Midgut    3.7   2.1  Hindgut    7   1.7  Malpighian Tubules    4.2   2.5  Fat Body    no informative data   7.8  Salivary Gland    8   NA  Heart    3.1   3.85  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    0.7   NA  Testis    2.5   NA  Male Accessory Gland    5.4   2.625  Carcass    4.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_16
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036046 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8167-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PP Ilp2Scer\UAS.cBa lethal, with Scer\GAL4ppl.PP Ilp2Scer\UAS.cBa viable Ilp21 viable, with Scer\GAL4pnr-MD237 Ilp2GD15756 Other Phenotypes Allele developmental rate defective Ilp21 increased cell number, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa increased cell size, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa large body Ilp2Scer\UAS.cBa large body, with Scer\GAL4arm.PS Ilp2Scer\UAS.cBa large body, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa long lived Ilp21 mating defective Ilp21 small body, with Scer\GAL4Ilp2.PR Ilp2GD15756 stress response defective, with Scer\GAL4Ilp2.PR Ilp2Scer\UAS.cBa visible, with Scer\GAL4hs.PB Ilp2Scer\UAS.cBa Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Ilp2 Class Mutagen Stocks Known lesion Ilp21 SCEI endonuclease FLPase 1 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ilp2 Class Mutagen Stocks Known lesion Ilp2GD15756 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Ilp2HMS00476 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp2JF01518 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp2KK110961 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ilp2hs.PR in vitro construct - regulatory fusion 0 Yes Ilp2Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes Ilp2Scer\UAS.cZa in vitro construct - regulatory fusion 0 Yes Ilp2Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Ilp2w.Scer\SceI.RS in vitro construct 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)AC1 (Brogiolo et al., 2001) Df(3L)Ilp1-4 (Grönke et al., 2010) Df(3L)Ilp1-5 (Zhang et al., 2009) Df(3L)Ilp2-3 (Grönke et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD15756} NA P{KK110961} NA P{TRiP.HMS00476} NA P{TRiP.JF01518} NA P{UAS-Ilp2.FLAG} NA characterization construct P{Ilp2-GAL4.215-3} NA P{Ilp2-GAL4.215-55} NA P{Ilp2-GAL4.R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
carbohydrate utilization inferred from mutant phenotype (Zhang et al., 2009) determination of adult lifespan inferred from mutant phenotype (Grönke et al., 2010) female mating behavior inferred from mutant phenotype (Wigby et al., 2011) germ-line stem-cell niche homeostasis inferred from mutant phenotype (Hsu and Drummond-Barbosa, 2009) insulin receptor signaling pathway inferred from genetic interaction with InR (Brogiolo et al., 2001) larval feeding behavior inferred from mutant phenotype (Wu et al., 2005) positive regulation of cell growth inferred from mutant phenotype (Zhang et al., 2009) positive regulation of multicellular organism growth inferred from mutant phenotype (Zhang et al., 2009) regulation of cell size inferred from mutant phenotype (Brogiolo et al., 2001) regulation of growth rate inferred from mutant phenotype (Grönke et al., 2010) regulation of multicellular organism growth inferred from mutant phenotype (Brogiolo et al., 2001) triglyceride homeostasis inferred from mutant phenotype (Zhang et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
hormone activity inferred from electronic annotation with InterPro:IPR016179 (FlyBase Curators et al., 2004-) non-traceable author statement (van den Broeck, 2000.11.27) insulin receptor binding inferred from sequence or structural similarity (Swiss-Prot Project Members, 2000.10.1) inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001)
Biological Process
CV term Evidence References
growth traceable author statement (Johnston and Gallant, 2002) insulin receptor signaling pathway inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001) traceable author statement (Johnston and Gallant, 2002) positive regulation of multicellular organism growth traceable author statement (Claeys et al., 2002, Johnston and Gallant, 2002)
Cellular Component
CV term Evidence References
extracellular region inferred from sequence or structural similarity with human INS (Brogiolo et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ilp2 allele Gene References Ilp2hs.PR rpr (Rulifson et al., 2002, Rulifson et al., 2002) Ilp2Scer\UAS.cBa InR (Brogiolo et al., 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64538 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036046 DroID - A comprehensive database of gene and protein interactions. • FBgn0036046 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39150
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24678 Dere\GG15413 Dgri\GH15432 Dmoj\GI13035 Dpse\GA20861 Dsec\GM25186 Dsim\GD14218 Dvir\GJ12130 Dwil\GK10990 Dyak\GE21720
Curated drosophilid orthologs	Dgri\GH15432 (Grönke et al., 2010) Dgri\GH15434 (Grönke et al., 2010) Dpse\GA20861
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000937-PA Aedes aegypti (mosquito) AGAP010602-PA Anopheles gambiae (mosquito) AGAP010604-PA Anopheles gambiae (mosquito) CPIJ018051 Culex pipens (mosquito) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0238966 FBgn0213001 FBgn0199382 FBgn0185904 FBgn0180046 FBgn0080851 FBgn0135792 FBgn0122906 FBgn0122904 FBgn0111332 FBgn0107664 FBgn0101671
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	30881 w1118; Ilp21 31068 y1 v1; P{TRiP.JF01518}attP2 32475 y1 sc* v1; P{TRiP.HMS00476}attP2/TM3, Sb1
VDRC	v102158 P{KK110961}VIE-260B v44760 w1118; P{GD15756}v44760/CyO v44761 w1118; P{GD15756}v44761/CyO
Genomic Clones ( 2 )
	BACR07A05 BACR07E07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 2 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH11579
Other clones	DPiM_GH11579
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036046 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39150
Antibody Information
	polyclonal (Veenstra et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079288 RefSeq (Proteins) • NP_524012 DDBJ / EMBL / GenBank • AAF50204 AAL39240 AI134194 AJ291726 AW940415 AY069095 CAC17605 Entrez Gene - A searchable database of RefSeq genes. • 39150 UniProtKB/Swiss-Prot • Q9VT51
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Insulin-like (IPR016179) Insulin family (IPR022352) Insulin, conserved site (IPR022353)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64538 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036046 DroID - A comprehensive database of gene and protein interactions. • FBgn0036046 DRSC - Results from RNAi screens. • FBgn0036046 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036046 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8167-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036046 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39150 InParanoid A subset of ortholog calls from InParanoid. • AAEL000937-PA Aedes aegypti (mosquito) AGAP010602-PA Anopheles gambiae (mosquito) AGAP010604-PA Anopheles gambiae (mosquito) CPIJ018051 Culex pipens (mosquito) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/dilp2.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39150 modMine - Data generated by the modENCODE project. • FBgn0036046 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0238966 FBgn0213001 FBgn0199382 FBgn0185904 FBgn0180046 FBgn0080851 FBgn0135792 FBgn0122906 FBgn0122904 FBgn0111332 FBgn0107664 FBgn0101671
Synonyms & Secondary IDs ( 28 )
Reported As
Symbol Synonym	CG8167 (Borras, 2003, Brogiolo et al., 2001, Keleman et al., 2009.8.5, Ni et al., 2008, Ni et al., 2010.12.1, Kim and Marqués, 2010) DILP (Wu et al., 2005, Nijhout, 2003, Drummond-Barbosa and Spradling, 2004, Nijhout, 2003, Cao and Brown, 2001) dilp (Belawat and Hafen, 2005) Dilp (Bradley and Leevers, 2003, Rhea et al., 2007) dILP-2 (Teleman and Cohen, 2006) Dilp2 (LaFever and Drummond-Barbosa, 2005, Clements et al., 2003, Arquier et al., 2007, Crocker et al., 2010, Honegger et al., 2008, Hsu and Drummond-Barbosa, 2008, Wang et al., 2007, Lee et al., 2008, Wang et al., 2009, Lee et al., 2009, Arquier et al., 2008, Agrawal et al., 2009, Delanoue et al., 2010, Birse et al., 2010, Demontis and Perrimon, 2010) dilp2 (Wang et al., 2005, Broughton et al., 2005, Li and White, 2003, Rhea et al., 2005, Cypser and Tatar, 2004, Tatar et al., 2003, Ikeya et al., 2002, Rulifson et al., 2002, Rulifson et al., 2002, Ikeya and Hafen, 2002, Brogiolo et al., 2001, Min et al., 2007, Flatt et al., 2005, Libert, 2007, Karpac et al., 2009, Mattaliano et al., 2007, Belgacem and Martin, 2006, Melcher and Pankratz, 2005, Slack et al., 2010, Corl et al., 2005, Wu et al., 2005, Flatt et al., 2008, Broughton et al., 2008, Kaplan et al., 2008, Hsu and Drummond-Barbosa, 2009, Amcheslavsky et al., 2009, Humphrey et al., 2009, Walkiewicz and Stern, 2009, Kaplan et al., 2008, Buch et al., 2008, Okamoto et al., 2009, Clements et al., 2008, Hull-Thompson et al., 2009, Giannakou et al., 2007, Nielsen et al., 2008, Zhang et al., 2009, Nässel et al., 2008, Wessells et al., 2009, Grönke et al., 2010, Ballard et al., 2010, Maynard et al., 2010, De Luca et al., 2010, Kahsai et al., 2010, Sekine et al., 2010, Wigby et al., 2011, Honegger et al., 2008, Alic et al., 2011, Wang et al., 2008, McClure et al., 2011, Park et al., 2011) DILP2 (Li and White, 2003, Bender et al., 2004, Rayburn et al., 2004, Leevers, 2001, Luong et al., 2006, Slaidina et al., 2009) dilp-2 (Hwangbo et al., 2004, Tountas and Fortini, 2007) dILP2 (Saucedo and Edgar, 2002, Park et al., 2008, Bauer et al., 2007, Teleman et al., 2008, Chell and Brand, 2010) Dilp 2 (Claeys et al., 2002) Dilp-2 (Hoshizaki and Gibbs, 2007) dIlp2 (Hewes et al., 2006, Boyd et al., 2011) Ilp (Edgar, 2006) ILP2 (Mellerick et al., 2003, Hahn et al., 2010) Ilp2 (Seugnet et al., 2009, Veenstra et al., 2008, Sousa-Nunes et al., 2011, Cognigni et al., 2011) ilp2 (Song et al., 2010, Veenstra, 2009, Xu et al., 2008, Min et al., 2008, Varghese et al., 2010, Wang et al., 2008) Ilp-2 (Veenstra et al., 2008, Pospisilik et al., 2010) IRP   unnamed (vanden Broeck, 2001)
Name Synonym	Drosophila insulin-like peptide 2 (Oldham and Hafen, 2003) Drosophila insulin like peptide 2 (Crocker et al., 2010) insulin-like peptide (Flatt et al., 2005, Lee et al., 2009) insulin-like peptide 2 (Brogiolo et al., 2001, Honegger et al., 2008, Veenstra, 2009, Arquier et al., 2008, Ballard et al., 2010) Insulin-like peptide 2   insulin-like peptide-2 (Min et al., 2008) Insulin-related peptide (van den Broeck, 2000.11.27) Insulin- related peptide 2 (Kim and Marqués, 2010)
Secondary FlyBase IDs
	FBgn0044432
References ( 130 )
Generate a list of	All references relating to this gene ( 130 )
List References by type	Research paper  ( 85 ) Supplementary material  ( 4 ) Review  ( 14 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 13 ) FlyBase analysis  ( 1 ) Conference report  ( 3 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 29 )
	Alic et al., 2011, Aging Cell 10(1): 137--147 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. [FBrf0212768] Boyd et al., 2011, Free Radical Biol. Med. 50(11): 1669--1678 Nectarine promotes longevity in Drosophila melanogaster. [FBrf0213612] Cheng et al., 2011, Cell 146(3): 435--447 Anaplastic Lymphoma Kinase Spares Organ Growth during Nutrient Restriction in Drosophila. [FBrf0214599] Cognigni et al., 2011, Cell Metab. 13(1): 92--104 Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. [FBrf0212594] McClure et al., 2011, Dis. Model Mech. 4(3): 335--346 A Drosophila model for fetal alcohol syndrome disorders: role for the insulin pathway. [FBrf0213698] O'Brien et al., 2011, Cell 147(3): 603--614 Altered modes of stem cell division drive adaptive intestinal growth. [FBrf0216512] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Shin et al., 2011, Science 334(6056): 670--674 Drosophila microbiome modulates host developmental and metabolic homeostasis via insulin signaling. [FBrf0216582] Sousa-Nunes et al., 2011, Nature 471(7339): 508--512 Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. [FBrf0214426] Wigby et al., 2011, Proc. Biol. Sci. 278(1704): 424--431 Insulin signalling regulates remating in female Drosophila. [FBrf0212666] Agrawal et al., 2010, J. Neurosci. 30(4): 1301--1313 Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin-producing neurons regulates systemic intracellular calcium homeostasis and flight. [FBrf0209847] Ballard et al., 2010, Dev. Biol. 337(2): 375--385 Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila. [FBrf0209816] Birse et al., 2010, Cell Metab. 12(5): 533--544 High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. [FBrf0212220] Chell and Brand, 2010, Cell 143(7): 1161--1173 Nutrition-responsive glia control exit of neural stem cells from quiescence. [FBrf0212551] Crocker et al., 2010, Neuron 65(5): 670--681 Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior. [FBrf0210214] De Luca et al., 2010, PLoS ONE 5(6): e11286 A conserved role for syndecan family members in the regulation of whole-body energy metabolism. [FBrf0211150] Delanoue et al., 2010, Dev. Cell 18(6): 1012--1021 The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. [FBrf0211284] Demontis and Perrimon, 2010, Cell 143(5): 813--825 FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging. [FBrf0212347] Grönke et al., 2010, PLoS Genet. 6(2): e1000857 Molecular evolution and functional characterization of Drosophila insulin-like peptides. [FBrf0210097] Hahn et al., 2010, Cell Metab. 11(5): 438--444 PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation. [FBrf0210726] Kahsai et al., 2010, PLoS ONE 5(7): e11480 Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides. [FBrf0211291] Kim and Marqués, 2010, Dev. Dyn. 239(9): 2413--2425 Identification of downstream targets of the Bone Morphogenetic Protein pathway in the Drosophila nervous system. [FBrf0211763] Maynard et al., 2010, Dev. Biol. 339(2): 295--306 Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. [FBrf0210107] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Sekine et al., 2010, J. Biol. Chem. 285(49): 38684--38691 Blocking O-Linked GlcNAc Cycling in Drosophila Insulin-producing Cells Perturbs Glucose-Insulin Homeostasis. [FBrf0212389] Shen and Tower, 2010, Exp. Gerontol. 45(2): 97--105 Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. [FBrf0209844] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Song et al., 2010, Cell Metab. 11(5): 427--437 SH2B regulation of growth, metabolism, and longevity in both insects and mammals. [FBrf0210745] Varghese et al., 2010, Genes Dev. 24(24): 2748--2753 Drosophila miR-14 regulates insulin production and metabolism through its target, sugarbabe. [FBrf0212621] Show all research papers ...
Recent reviews ( 1 )
	Teleman, 2010, Biochem. J. 425(1): 13--26 Molecular mechanisms of metabolic regulation by insulin in Drosophila. [FBrf0209514] Show all reviews ...