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Gene Dmel\iPLA2-VIA

General Information
Symbol	Dmel\iPLA2-VIA	Species	D. melanogaster
Name	calcium-independent phospholipase A2 VIA	Annotation symbol	CG6718
Feature type	protein_coding_gene	FlyBase ID	FBgn0036053
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67C11-67C11	Sequence location	3L:9,853,317..9,857,459 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene calcium-independent phospholipase A2 VIA is referred to in FlyBase by the symbol Dmel\iPLA2-VIA (CG6718, FBgn0036053). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium-independent phospholipase A2 activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: lipid metabolic process. 6 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Acyl transferase/acyl hydrolase/lysophospholipase; Ankyrin repeat; Ankyrin repeat-containing domain; Patatin/Phospholipase A2-related. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult fat body, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1636791_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of iPLA2-VIA. Gene sequence location is 3L:9853317..9857459.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67C11-67C11   Limits computationally determined from genome sequence between P{PZ}fry02240 and P{lacW}l(3)L0539L0539&P{PZ}Dhh1rL562
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\iPLA2-VIA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated. DGC clone appears problematic (LD44515): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) iPLA2-VIA-RA FBtr0076362  NM_140109   3279   877 iPLA2-VIA-RB FBtr0076363  NM_168383   3417   887 iPLA2-VIA-RC FBtr0076364  NM_168384   3695   887 iPLA2-VIA-RD FBtr0076365  NM_168385   3602   887
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein iPLA2-VIA-PA   FBpp0076091   96.9   877   6.98     NP_648366   AAF50194 iPLA2-VIA-PB   FBpp0076092   97.8   887   6.98     NP_729565   AAN11936 iPLA2-VIA-PC   FBpp0076093   97.8   887   6.98     NP_729566   AAN11937 iPLA2-VIA-PD   FBpp0076094   97.8   887   6.98     NP_729567   AAN11938
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Patatin/Phospholipase A2-related (IPR002641) Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035) Ankyrin repeat-containing domain (IPR020683)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50194   AE014296 AAN11936   AE014296 AAN11937   AE014296 AAN11938   AI512596   AI517498   AI532313   AW943728   AY122192 AAM52704   BF497662   BF500959   BF502812   BF504123   BG640065   BG641405   BG641422   BI173670   BI216554   BI232884   BI374836   BI578764   BI579014   BI638183   BT024215   BT125951   CO156392   CO184119   CO276406   CO288163   CO308935   CO311806   CO317502   CO318885   CO321837   CO324977   CZ478235   EC066325   EC076606   EC078125   EC086323   EC216820   EC227320   EC230585   EC243421   EC249254   EC263986   EV577149   EV582703   GH944545
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KUD4 Q9VT60 Q8MR13
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult fat body, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body    539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca    636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body  (539.5) Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca  (636.4) Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body    539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca    636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body    539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca    636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body    539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca    636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body  539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca  636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body    539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca    636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    276.675 Larval Midgut    175.8 Larval Hindgut    183.2 Larval Malpighian Tubules    285.4 Larval Fat Body    221.5 Larval Salivary Gland    267.3 Larval Trachea    180.125 Larval Carcass    209.575 Adult Head    277.2 Adult Eye    328.9 Adult Brain    265.2 Adult Thoracic-Abdominal Ganglion    261 Adult Crop    365.4 Adult Midgut    180.7 Adult Hindgut    236.9 Adult Malpighian Tubules    262.4 Adult Fat Body    539.5 Adult Salivary Gland    482.2 Adult Heart    362.975 Adult VirginFemale Spermatheca    636.4 Adult InseminatedFemale Spermatheca    463.1 Adult Ovary    401 Adult Testis    106.9 Adult Male Accessory Gland    478.2 Adult Carcass    418.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    277.2   NA  Eye    328.9   NA  Brain    265.2   276.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    261   NA  Crop    365.4   175.8  Midgut    180.7   183.2  Hindgut    236.9   285.4  Malpighian Tubules    262.4   221.5  Fat Body    539.5   267.3  Salivary Gland    482.2   NA  Heart    362.975   180.125  Trachea    NA   NA  VirginFemale Spermatheca    636.4   NA  InseminatedFemale Spermatheca    463.1   NA  Ovary    401   NA  Testis    106.9   NA  Male Accessory Gland    478.2   209.575  Carcass    418.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    26 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female    80 ovary, mated 4-day female    62 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male  26 head, mated 4-day male  (30) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female  (80) ovary, mated 4-day female  (62) testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    26 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female    80 ovary, mated 4-day female    62 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    26 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female    80 ovary, mated 4-day female    62 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    26 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female    80 ovary, mated 4-day female    62 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male  26 head, mated 4-day male  30 head, mated 20-day male  (44) salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female  (80) ovary, mated 4-day female  (62) testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    26 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female    80 ovary, mated 4-day female    62 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    23 central nervous system, larvae L3    22 central nervous system, pupae P8    22 head, virgin 1-day female    25 head, virgin 4-day female    20 head, virgin 20-day female    24 head, mated 1-day female    18 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    26 head, mated 4-day male    30 head, mated 20-day male    44 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    8 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    17 digestive system, 4-day adult    18 digestive system, 20-day adult    19 fat body, larvae L3 wandering    11 fat body, white prepupae    13 fat body, pupae P8    13 carcass, larvae L3 wandering    22 carcass, 1-day adult    25 carcass, 4-day adult    23 carcass, 20-day adult    24 ovary, virgin 4-day female    80 ovary, mated 4-day female    62 testis, mated 4-day male    18 accessory gland, mated 4-day male    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day    26 adult male 05day    26 adult male 30day    30 adult female 01day    36 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr  (28) embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  (28) white prepupae new  (27) white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day  26 adult male 05day  26 adult male 30day  (30) adult female 01day  (36) adult female 05day  (51) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day    26 adult male 05day    26 adult male 30day    30 adult female 01day    36 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day    26 adult male 05day    26 adult male 30day    30 adult female 01day    36 adult female 05day    51 adult female 30day    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day    26 adult male 05day    26 adult male 30day    30 adult female 01day    36 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (57) embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr  28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9  28 white prepupae new  27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day  26 adult male 05day  26 adult male 30day  30 adult female 01day  (36) adult female 05day  (51) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day    26 adult male 05day    26 adult male 30day    30 adult female 01day    36 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    57 embryo 02-04hr    8 embryo 04-06hr    17 embryo 06-08hr    28 embryo 08-10hr    22 embryo 10-12hr    19 embryo 12-14hr    15 embryo 14-16hr    15 embryo 16-18hr    14 embryo 18-20hr    12 embryo 20-22hr    9 embryo 22-24hr    12 larva L1    16 larva L2    19 larva L3 12hr old    18 larva L3 puffstage 1-2    17 larva L3 puffstage 3-6    22 larva L3 puffstage 7-9    28 white prepupae new    27 white prepupae 12hr    18 white prepupae 24hr    21 pupae 2d postWPP    16 pupae 3d postWPP    12 pupae 4d postWPP    12 adult male 01day    26 adult male 05day    26 adult male 30day    30 adult female 01day    36 adult female 05day    51 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    107 Schneider line 2 Sg4    74 embryonic 1182-4H    80 embryonic GM2    92 embryonic Kc167    70 embryonic S1    59 embryonic S3    98 leg disc CME L1    69 wing disc CME-W2    90 wing disc ML-DmD8    45 wing disc ML-DmD9    50 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    39 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    233 ovary fGS/OSS    35 ovary OSC    47 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (107) Schneider line 2 Sg4  (74) embryonic 1182-4H  (80) embryonic GM2  (92) embryonic Kc167  (70) embryonic S1  (59) embryonic S3  (98) leg disc CME L1  (69) wing disc CME-W2  (90) wing disc ML-DmD8  (45) wing disc ML-DmD9  (50) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (39) wing disc ML-DmD32  (35) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (54) CNS ML-DmBG2-c2  (82) tumorous blood cells mbn2  (233) ovary fGS/OSS  (35) ovary OSC  (47) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  107 Schneider line 2 Sg4    74 embryonic 1182-4H    80 embryonic GM2    92 embryonic Kc167    70 embryonic S1    59 embryonic S3    98 leg disc CME L1    69 wing disc CME-W2    90 wing disc ML-DmD8    45 wing disc ML-DmD9    50 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    39 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2  (233) ovary fGS/OSS    35 ovary OSC    47 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    107 Schneider line 2 Sg4    74 embryonic 1182-4H    80 embryonic GM2    92 embryonic Kc167    70 embryonic S1    59 embryonic S3    98 leg disc CME L1    69 wing disc CME-W2    90 wing disc ML-DmD8    45 wing disc ML-DmD9    50 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    39 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    233 ovary fGS/OSS    35 ovary OSC    47 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    107 Schneider line 2 Sg4    74 embryonic 1182-4H    80 embryonic GM2    92 embryonic Kc167    70 embryonic S1    59 embryonic S3    98 leg disc CME L1    69 wing disc CME-W2    90 wing disc ML-DmD8    45 wing disc ML-DmD9    50 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    39 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    233 ovary fGS/OSS    35 ovary OSC    47 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (107) Schneider line 2 Sg4  (74) embryonic 1182-4H  (80) embryonic GM2  (92) embryonic Kc167  (70) embryonic S1  (59) embryonic S3  (98) leg disc CME L1  (69) wing disc CME-W2  (90) wing disc ML-DmD8  (45) wing disc ML-DmD9  (50) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (39) wing disc ML-DmD32  (35) haltere disc ML-DmD17-c3  (61) eye-antennal disc ML-DmD11  (48) antennal disc ML-DmD20-c5  (67) mixed discs ML-DmD4-c1  (48) CNS ML-DmBG1-c1  (54) CNS ML-DmBG2-c2  (82) tumorous blood cells mbn2  (233) ovary fGS/OSS  (35) ovary OSC  (47) ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  107 Schneider line 2 Sg4    74 embryonic 1182-4H    80 embryonic GM2    92 embryonic Kc167    70 embryonic S1    59 embryonic S3    98 leg disc CME L1    69 wing disc CME-W2    90 wing disc ML-DmD8    45 wing disc ML-DmD9    50 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    39 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2  (233) ovary fGS/OSS    35 ovary OSC    47 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    107 Schneider line 2 Sg4    74 embryonic 1182-4H    80 embryonic GM2    92 embryonic Kc167    70 embryonic S1    59 embryonic S3    98 leg disc CME L1    69 wing disc CME-W2    90 wing disc ML-DmD8    45 wing disc ML-DmD9    50 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    39 wing disc ML-DmD32    35 haltere disc ML-DmD17-c3    61 eye-antennal disc ML-DmD11    48 antennal disc ML-DmD20-c5    67 mixed discs ML-DmD4-c1    48 CNS ML-DmBG1-c1    54 CNS ML-DmBG2-c2    82 tumorous blood cells mbn2    233 ovary fGS/OSS    35 ovary OSC    47 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    62 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult  (33) Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  (31) Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  (32) Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (56) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (62) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    62 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    62 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    62 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult  (33) Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult  31 Cadmium 100 mM 48 hrs, 4-day adult  (66) Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult  (45) Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult  32 Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (56) Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult  (49) Paraquat 10 mM 48 hrs, 4-day adult  (62) Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    62 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    17 cold shock, 4-day adult    12 heat shock, 4-day adult    33 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    23 Cadmium 50 mM 48 hrs, 4-day adult    31 Cadmium 100 mM 48 hrs, 4-day adult    66 Copper 0.5 mM 12 hrs, larvae L3    10 Copper 15 mM 48 hrs, 4-day adult    45 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    32 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    24 Ethanol 10% 3 hrs, larvae L3    18 Caffeine 1.5 mg/ml 4 hrs, larvae L3    24 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    56 Caffeine 25 mg/ml 48 hrs, 4-day adult    22 Paraquat 5 mM 48 hrs, 4-day adult    49 Paraquat 10 mM 48 hrs, 4-day adult    62 Rotenone 2 μg 12 hrs, larvae L3    22 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_02 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • LP03302 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6718-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of iPLA2-VIA Class Mutagen Stocks Known lesion iPLA2-VIAe00344 piggyBac transposase 1 -- iPLA2-VIAEY05103 P-element activity 1 -- iPLA2-VIAGS10408 1 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of iPLA2-VIA Class Mutagen Stocks Known lesion iPLA2-VIAHMS01544 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes iPLA2-VIAKK101305 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes iPLA2-VIAGD12015 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{KK101305} NA P{TRiP.HMS01544} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}iPLA2-VIAEY05103 NA P{GSV6}iPLA2-VIAGS10408 NA miscellaneous insertions PBac{RB}iPLA2-VIAe00344 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
calcium-independent phospholipase A2 activity inferred from sequence or structural similarity with EMBL:U88624 (FlyBase, 1992-)
Biological Process
CV term Evidence References
lipid metabolic process inferred from electronic annotation with InterPro:IPR002641 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity with EMBL:U88624 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
iPLA2-VIA - CG3862 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions iPLA2-VIA allele Gene References unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64547 DroID - A comprehensive database of gene and protein interactions. • FBgn0036053 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39160
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GXG64 Dipteran inclusive ortholog search EOG673Q0B Insect inclusive ortholog search EOG6X3FW8 Arthropod inclusive ortholog search EOG68GTJ8 Metazoa inclusive ortholog search EOG6N67PR
Orthologs in Drosophila Species (EOG6GXG64)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\iPLA2-VIA     Drosophila simulans   Dsim\GD12885 Y   Drosophila sechellia   Dsec\GM24833 Y   Drosophila erecta   Dere\GG13998 Y   Drosophila yakuba   Dyak\GE20294 Y   Drosophila ananassae   Dana\GF24681 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA23437 Y   Drosophila persimilis   Dper\GL16301 Y   Drosophila willistoni   Dwil\GK11034 Y   Drosophila virilis   Dvir\GJ12510 Y   Drosophila mojavensis   Dmoj\GI16765 Y   Drosophila grimshawi   Dgri\GH15489 Y
Orthologs in non-Drosophila Dipterans (EOG673Q0B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012835   Anopheles gambiae Malaria mosquito  Agam\AGAP004812   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007422   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ020165
Orthologs in non-Dipteran Insects (EOG6X3FW8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC410570   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG029889   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG024225   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004238   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004237   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22187   Atta cephalotes Leafcutter ant  Acep\ACEP13632   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18484   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17693   Linepithema humile Argentine ant  Lhum\LH20484   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20332   Solenopsis invicta Red fire ant  Sinv\SINV24192   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005738   Bombyx mori Silkmoth  Bmor\BGIBMGA011625   Pediculus humanus Human body louse  Phum\PHUM565780   Tribolium castaneum Red flour beetle  Tcas\TC003390
Orthologs in non-Insect Arthropods (EOG68GTJ8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\argF   Daphnia pulex Water flea  Dpux\GRAMD3   Daphnia pulex Water flea  Dpux\Pdcd2   Ixodes scapularis Deer tick  Isca\ISCW016227
Orthologs in non-Arthropod Metazoa (EOG6N67PR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F47A4.5   Caenorhabditis elegans Nematode  Cele\W07A8.2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028407gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023609gn   Danio rerio Zebrafish  Drer\pla2g6   Xenopus tropicalis Western clawed frog  Xtro\pla2g6   Gallus gallus Domestic chicken  Ggal\PLA2G6   Mus musculus House mouse  Mmus\Pla2g6   Rattus norvegicus Norway rat  Rnor\Pla2g6   Homo sapiens Human  Hsap\PLA2G6
Human Orthologs (1)
Gene OMIM HGNC Hsap\PLA2G6
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12885 Drosophila sechellia Dsec\GM24833 Drosophila erecta Dere\GG13998 Drosophila yakuba Dyak\GE20294 Drosophila ananassae Dana\GF24681 Drosophila pseudoobscura pseudoobscura Dpse\GA23437 Drosophila persimilis Dper\GL16301 Drosophila willistoni Dwil\GK11034 Drosophila virilis Dvir\GJ12510 Drosophila mojavensis Dmoj\GI16765 Drosophila grimshawi Dgri\GH15489
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	36129 y1 sc* v1; P{TRiP.HMS01544}attP2 15947 y1 w67c23; P{EPgy2}iPLA2-VIAEY05103
Harvard	- PBac{RB}iPLA2-VIAe00344
Kyoto	202540 y1 w67c23; P{GSV6}iPLA2-VIAGS10408/TM3, Sb1 Ser1
VDRC	v108294 P{KK101305}VIE-260B
Genomic Clones ( 1 )
	BACR07A05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 41 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44515 LP03302 RE23733
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05421 AT11878 AT16126 AT18641 RE16742 RE29032 RE62519 RE72680 RE72978 SD03776 SD11004 SD12737 SD12756 SD20409
Other clones	66837 106779 145966 156935 163953 174103 283619 527805 CK01.85D.H8 CK01.147B.D2 Dmel_dig_011955_0671_3429 Dmel_dig_016677_0589_3233 EC27165 EK067864 EK120745 EK186506 EK195262 EK226608 EK259719 EK268360 EK274813 EN07958 GH28478 RP004239674
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39160
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: iPLA2-VIA CG6718 (Malhotra et al., 2009)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140109 NM_168383 NM_168384 NM_168385 RefSeq (Proteins) • NP_648366 NP_729565 NP_729566 NP_729567 DDBJ / EMBL / GenBank • AAF50194 AAM52704 AAN11936 AAN11937 AAN11938 AI512596 AW943728 AY122192 BI173670 BI216554 CZ478235 Entrez Gene - A searchable database of RefSeq genes. • 39160 UniProtKB/TrEMBL • Q7KUD4 Q8MR13 Q9VT60
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ankyrin repeat (IPR002110) Patatin/Phospholipase A2-related (IPR002641) Acyl transferase/acyl hydrolase/lysophospholipase (IPR016035) Ankyrin repeat-containing domain (IPR020683) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LP03302
Linkouts
	BioGRID - A database of protein and genetic interactions • 64547 DroID - A comprehensive database of gene and protein interactions. • FBgn0036053 DRSC - Results from RNAi screens. • FBgn0036053 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036053 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6718-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036053 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39160 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39160 modMine - Data generated by the modENCODE project. • FBgn0036053
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG6718 (Gregory et al., 2007, Hollien and Weissman, 2006, Montana and Littleton, 2006, Malhotra et al., 2009, Malhotra et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Qurashi et al., 2012) iPLA2-VIA (Malhotra et al., 2009, Qurashi et al., 2012)
Name Synonym	calcium-independent phospholipase A2 VIA   CG6718   phospholipase A2 (Malhotra et al., 2009)
Secondary FlyBase IDs
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 6 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Qurashi et al., 2012, Hum. Mol. Genet. 21(9): 2068--2075 Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. [FBrf0217893] Schlame et al., 2012, Chem. Phys. Lipids 165(5): 512--519 Comparison of cardiolipins from Drosophila strains with mutations in putative remodeling enzymes. [FBrf0219234] Show all research papers ...