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Gene Dmel\CG11811

General Information
Symbol	Dmel\CG11811	Species	D. melanogaster
Name		Annotation symbol	CG11811
Feature type	protein_coding_gene	FlyBase ID	FBgn0036099
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67E6-67E7	Sequence location	3L:10,684,117..10,685,701 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG11811 (FBgn0036099). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: guanylate kinase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: purine nucleotide metabolic process. 5 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Guanylate kinase; Guanylate kinase, conserved site; Guanylate kinase, sub-group; Guanylate kinase/L-type calcium channel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640421_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11811. Gene sequence location is 3L:10684117..10685701.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN50813 BKN51173 BKN27347 HFA09862
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67E6-67E7   Limits computationally determined from genome sequence between P{PZ}simj01814 and P{lacW}tnaL6731
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG11811 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG11811-RA FBtr0076265  NM_140151   1585   233
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG11811-PA   FBpp0075994   25.9   233   7.57     NP_648408   AAF50139
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Guanylate kinase (IPR008144) Guanylate kinase/L-type calcium channel (IPR008145) Guanylate kinase, sub-group (IPR017665) Guanylate kinase, conserved site (IPR020590)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201704   AA246299   AA390467   AA391526   AA438680   AA696663   AA696889   AA802685   AA816337   AE014296 AAF50139   AI107298   AI518224   AY070835   AY071035 AAL48657   BI161921   BI161922   BI170490   BI170976   BI213046   BI213786   BI216476   BI236676   BI237197   BI237533   BI237692   BI362172   BI362932   BI364076   BI374174   BI482382   BI483393   BI485992   BI577200   BI580232   BI580533   BP547850   BP554020   BP555852   CK657911   CL525877   CL525878   CO177611   CO188016   CO189459   CO190765   CO261938   CO265813   CO268678   CO290864   CO295810   CO299650   CO301445   CO305394   CO316978   CO323651   CO323957   CO324714   CO326926   CO331555   CO331996   CO333910   CZ480527   CZ480528   DN154382   EC051209   EC052204   EC053165   EC053636   EC054156   EC055594   EC056179   EC056327   EC056929   EC061400   EC067769   EC067988   EC070425   EC073692   EC079716   EC082244   EC085504   EC195200   EC200282   EC203420   EC208313   EC212888   EC218438   EC222312   EC223730   EC224006   EC239659   EC241190   EV586450   EV588849   EV589939   GH768186   GH769241   GH769321
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VTB3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036099    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036099 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during early larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036099 expression level Developmental Stage   Expression Level embryo 00-02hr    5362 embryo 02-04hr    3730 embryo 04-06hr    2328 embryo 06-08hr    3000 embryo 08-10hr    3777 embryo 10-12hr    5195 embryo 12-14hr    3746 embryo 14-16hr    2883 embryo 16-18hr    3019 embryo 18-20hr    3144 embryo 20-22hr    5264 embryo 22-24hr    5286 larva L1    4011 larva L2    2883 larva L3 12hr old    3043 larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6    1559 larva L3 puffstage 7-9    1797 white prepupae new    1650 white prepupae 12hr    1498 white prepupae 24hr    1496 pupae 2d postWPP    1902 pupae 3d postWPP    1480 pupae 4d postWPP    2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day    1899 adult female 05day    3549 adult female 30day    3537 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5362) embryo 02-04hr  (3730) embryo 04-06hr  (2328) embryo 06-08hr  (3000) embryo 08-10hr  (3777) embryo 10-12hr  (5195) embryo 12-14hr  (3746) embryo 14-16hr  (2883) embryo 16-18hr  (3019) embryo 18-20hr  (3144) embryo 20-22hr  (5264) embryo 22-24hr  (5286) larva L1  (4011) larva L2  (2883) larva L3 12hr old  (3043) larva L3 puffstage 1-2  (1304) larva L3 puffstage 3-6  (1559) larva L3 puffstage 7-9  (1797) white prepupae new  (1650) white prepupae 12hr  (1498) white prepupae 24hr  (1496) pupae 2d postWPP  (1902) pupae 3d postWPP  (1480) pupae 4d postWPP  (2391) adult male 01day  (743) adult male 05day  (698) adult male 30day  (640) adult female 01day  (1899) adult female 05day  (3549) adult female 30day  (3537) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5362) embryo 02-04hr  (3730) embryo 04-06hr  (2328) embryo 06-08hr  (3000) embryo 08-10hr  (3777) embryo 10-12hr  (5195) embryo 12-14hr  (3746) embryo 14-16hr  (2883) embryo 16-18hr  (3019) embryo 18-20hr  (3144) embryo 20-22hr  (5264) embryo 22-24hr  (5286) larva L1  (4011) larva L2  (2883) larva L3 12hr old  (3043) larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6  (1559) larva L3 puffstage 7-9  (1797) white prepupae new  (1650) white prepupae 12hr  1498 white prepupae 24hr  1496 pupae 2d postWPP  (1902) pupae 3d postWPP  1480 pupae 4d postWPP  (2391) adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day  (1899) adult female 05day  (3549) adult female 30day  (3537) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5362 embryo 02-04hr    3730 embryo 04-06hr    2328 embryo 06-08hr    3000 embryo 08-10hr    3777 embryo 10-12hr    5195 embryo 12-14hr    3746 embryo 14-16hr    2883 embryo 16-18hr    3019 embryo 18-20hr    3144 embryo 20-22hr    5264 embryo 22-24hr    5286 larva L1    4011 larva L2    2883 larva L3 12hr old    3043 larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6    1559 larva L3 puffstage 7-9    1797 white prepupae new    1650 white prepupae 12hr    1498 white prepupae 24hr    1496 pupae 2d postWPP    1902 pupae 3d postWPP    1480 pupae 4d postWPP    2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day    1899 adult female 05day    3549 adult female 30day    3537 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5362 embryo 02-04hr    3730 embryo 04-06hr    2328 embryo 06-08hr    3000 embryo 08-10hr    3777 embryo 10-12hr    5195 embryo 12-14hr    3746 embryo 14-16hr    2883 embryo 16-18hr    3019 embryo 18-20hr    3144 embryo 20-22hr    5264 embryo 22-24hr    5286 larva L1    4011 larva L2    2883 larva L3 12hr old    3043 larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6    1559 larva L3 puffstage 7-9    1797 white prepupae new    1650 white prepupae 12hr    1498 white prepupae 24hr    1496 pupae 2d postWPP    1902 pupae 3d postWPP    1480 pupae 4d postWPP    2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day    1899 adult female 05day    3549 adult female 30day    3537 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036099 expression level Developmental Stage   Expression Level embryo 00-02hr    5362 embryo 02-04hr    3730 embryo 04-06hr    2328 embryo 06-08hr    3000 embryo 08-10hr    3777 embryo 10-12hr    5195 embryo 12-14hr    3746 embryo 14-16hr    2883 embryo 16-18hr    3019 embryo 18-20hr    3144 embryo 20-22hr    5264 embryo 22-24hr    5286 larva L1    4011 larva L2    2883 larva L3 12hr old    3043 larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6    1559 larva L3 puffstage 7-9    1797 white prepupae new    1650 white prepupae 12hr    1498 white prepupae 24hr    1496 pupae 2d postWPP    1902 pupae 3d postWPP    1480 pupae 4d postWPP    2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day    1899 adult female 05day    3549 adult female 30day    3537 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5362) embryo 02-04hr  (3730) embryo 04-06hr  (2328) embryo 06-08hr  (3000) embryo 08-10hr  (3777) embryo 10-12hr  (5195) embryo 12-14hr  (3746) embryo 14-16hr  (2883) embryo 16-18hr  (3019) embryo 18-20hr  (3144) embryo 20-22hr  (5264) embryo 22-24hr  (5286) larva L1  (4011) larva L2  (2883) larva L3 12hr old  (3043) larva L3 puffstage 1-2  (1304) larva L3 puffstage 3-6  (1559) larva L3 puffstage 7-9  (1797) white prepupae new  (1650) white prepupae 12hr  (1498) white prepupae 24hr  (1496) pupae 2d postWPP  (1902) pupae 3d postWPP  (1480) pupae 4d postWPP  (2391) adult male 01day  (743) adult male 05day  (698) adult male 30day  (640) adult female 01day  (1899) adult female 05day  (3549) adult female 30day  (3537) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5362) embryo 02-04hr  (3730) embryo 04-06hr  2328 embryo 06-08hr  (3000) embryo 08-10hr  (3777) embryo 10-12hr  (5195) embryo 12-14hr  (3746) embryo 14-16hr  (2883) embryo 16-18hr  (3019) embryo 18-20hr  (3144) embryo 20-22hr  (5264) embryo 22-24hr  (5286) larva L1  (4011) larva L2  (2883) larva L3 12hr old  (3043) larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6  1559 larva L3 puffstage 7-9  1797 white prepupae new  1650 white prepupae 12hr  1498 white prepupae 24hr  1496 pupae 2d postWPP  1902 pupae 3d postWPP  1480 pupae 4d postWPP  2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day  1899 adult female 05day  (3549) adult female 30day  (3537) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5362 embryo 02-04hr    3730 embryo 04-06hr    2328 embryo 06-08hr    3000 embryo 08-10hr    3777 embryo 10-12hr    5195 embryo 12-14hr    3746 embryo 14-16hr    2883 embryo 16-18hr    3019 embryo 18-20hr    3144 embryo 20-22hr    5264 embryo 22-24hr    5286 larva L1    4011 larva L2    2883 larva L3 12hr old    3043 larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6    1559 larva L3 puffstage 7-9    1797 white prepupae new    1650 white prepupae 12hr    1498 white prepupae 24hr    1496 pupae 2d postWPP    1902 pupae 3d postWPP    1480 pupae 4d postWPP    2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day    1899 adult female 05day    3549 adult female 30day    3537 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5362 embryo 02-04hr    3730 embryo 04-06hr    2328 embryo 06-08hr    3000 embryo 08-10hr    3777 embryo 10-12hr    5195 embryo 12-14hr    3746 embryo 14-16hr    2883 embryo 16-18hr    3019 embryo 18-20hr    3144 embryo 20-22hr    5264 embryo 22-24hr    5286 larva L1    4011 larva L2    2883 larva L3 12hr old    3043 larva L3 puffstage 1-2    1304 larva L3 puffstage 3-6    1559 larva L3 puffstage 7-9    1797 white prepupae new    1650 white prepupae 12hr    1498 white prepupae 24hr    1496 pupae 2d postWPP    1902 pupae 3d postWPP    1480 pupae 4d postWPP    2391 adult male 01day    743 adult male 05day    698 adult male 30day    640 adult female 01day    1899 adult female 05day    3549 adult female 30day    3537 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036099    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036099 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036099 expression level Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass    509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary    541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass  509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary  (541.6) Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass    509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary    541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass    509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary    541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036099 expression level Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass    509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary    541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass  509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary  541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass    509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary    541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    397.15 Larval Midgut    215.1 Larval Hindgut    318.4 Larval Malpighian Tubules    192.3 Larval Fat Body    384 Larval Salivary Gland    441.6 Larval Trachea    367.4 Larval Carcass    509.425 Adult Head    148.2 Adult Eye    130.275 Adult Brain    152.2 Adult Thoracic-Abdominal Ganglion    141.8 Adult Crop    276.8 Adult Midgut    117.7 Adult Hindgut    137.3 Adult Malpighian Tubules    127.1 Adult Fat Body    251.7 Adult Salivary Gland    151.5 Adult Heart    156.775 Adult VirginFemale Spermatheca    122.8 Adult InseminatedFemale Spermatheca    148.4 Adult Ovary    541.6 Adult Testis    65.8 Adult Male Accessory Gland    119.2 Adult Carcass    158.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    148.2   NA  Eye    130.275   NA  Brain    152.2   397.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    141.8   NA  Crop    276.8   215.1  Midgut    117.7   318.4  Hindgut    137.3   192.3  Malpighian Tubules    127.1   384  Fat Body    251.7   441.6  Salivary Gland    151.5   NA  Heart    156.775   367.4  Trachea    NA   NA  VirginFemale Spermatheca    122.8   NA  InseminatedFemale Spermatheca    148.4   NA  Ovary    541.6   NA  Testis    65.8   NA  Male Accessory Gland    119.2   509.425  Carcass    158.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036099 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11811-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for CG11811 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable CG11811EY03154 viable, with Scer\GAL4pnr-MD237 CG11811GD5872 Sterility Allele fertile CG11811EY03154 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 CG11811GD5872 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 CG11811GD5872
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of CG11811 Class Mutagen Stocks Known lesion CG11811e02756 piggyBac transposase 1 -- CG11811EY03154 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG11811 Class Mutagen Stocks Known lesion CG11811GD5872 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG11811GL00163 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG11811KK107347 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5872} NA P{KK107347} NA P{TRiP.GL00163} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}CG11811EY03154 NA miscellaneous insertions PBac{RB}CG11811e02756 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
guanylate kinase activity inferred from sequence or structural similarity with UniProtKB:P31006 (FlyBase, 1992-)
Biological Process
CV term Evidence References
purine nucleotide metabolic process inferred from electronic annotation with InterPro:IPR017665 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG11811 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64590 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036099 DroID - A comprehensive database of gene and protein interactions. • FBgn0036099 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39213
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10608 Dere\GG15450 Dgri\GH15906 Dmoj\GI16558 Dper\GL20800 Dpse\GA11213 Dsec\GM25224 Dsim\GD14257 Dvir\GJ12810 Dwil\GK17399 Dyak\GE21760
Curated drosophilid orthologs	Dpse\GA11213
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011006-PA Aedes aegypti (mosquito) AGAP011105-PA Anopheles gambiae (mosquito) XP_624407.1 Apis mellifera (honey bee) XP_001944743.1 Acyrthosiphon pisum (pea aphid) At3g06200.1 Arabidopsis thaliana (wall cress) 19206 Batrachochytrium dendrobatidis (chytrid fungus) 123769 Branchiostoma floridae (lancelet) XP_001893301.1 Brugia malayi (roundworm nematode) BGIBMGA003451-PA Bombyx mori (silk worm) ENSBTAP00000019656 Bos taurus (bovine) CAL0001880 Candida albicans (a form of yeast) CN20825 Caenorhabditis brenneri (small nematode) CN24682 Caenorhabditis brenneri (small nematode) CBP02919 Caenorhabditis briggsae (nematode) CE29460 Caenorhabditis elegans (worm) ENSCAFP00000001672 Canis familiaris (dog) CAGL0K06281g Candida glabrata (haploid yeast) ENSCINP00000014171 Ciona intestinalis (sea squirt) JA07639 Caenorhabditis japonica (nematode) CMD076C Cyanidioschyzon merolae (red alga) CMI041C Cyanidioschyzon merolae (red alga) cn04155 Cryptococcus neoformans (yeast-like fungus) cgd7_2190 Cryptosporidium parvum (protozoan parasite) CPIJ007795 Culex pipens (mosquito) ENSCPOP00000014501 Cavia porcellus (guinea pig) 174270 Chlamidomonas reinhardtii (green alga) RP07555 Caenorhabditis remanei (nematode) ENSCSAVP00000004136 Ciona savignyi (sedentary tunicate) 152418 Capitella spl (polychaete worm) DDB0230100 Dictyostelium discoideum (amoeba) DEHA2G07898g Debaryomyces Hansenii (yeast) 231676 Daphnia pulex (daphnia) ENSDARP00000023640 Danio rerio (zebra fish) ENSECAP00000016942 Equus caballus (horse) NP_418105.1 Escherichia coli K12 (bacteria) XP_654104 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023053 Gymnopilus aculeatus (mushroom) ENSGALP00000008546 Gallus gallus (chicken) GL50803_7203 Giardia lamblia (flagellated protozoan) 155295 Hypsipyla robusta (cedar shoot borer) ISCW011552-PA Ixodes scapularis (deer tick) KLLA0B01694g Kluyveromyces lactis (yeast) 143665 Lottia gigantea (owl limpet) LmjF33.1090 Leishmania major (virus) 33796 Monocosta brevicollis (choanoflagellate) ENSMODP00000031359 Monodelphis domestica (gray opossum) ENSMUSP00000099763 Mus musculus (house mouse) 205628 Nematostella vectensis (starlet anemone) XP_001601528.1 Nasonia vitripennis (wasp) ENSOANP00000023348 Ornithorynchus anatinus (platypus) ENSORLP00000021996 Oryzias latipes (japanese killifish) LOC_Os12g33100.1 Oryza sativa (asian rice) 23005 Ostreococcus tauri (green alga) PFI1420w Plasmodium falciparum (protozoal parasite) PHUM000217-PA Pediculus humanus (human body louse) PP23284 Pristionchus pacificus (nematode) 148828 Physcomitrella patens (moss) ENSPPYP00000000143 Pongo pygmaeus (orangutan) 652750 Populus trichocarpa (black cottonwood) PVX_099895 Plasmodium vivax (protozoal parasite) ENSRNOP00000003926 Rattus norvegicus (norway rat) 4989453 Sorghum bicolor (sorghum) YDR454C Saccharomyces cerevisiae (budding yeast) Smp_137940 Schistosoma mansoni (trematode parasite) SPBC1198.05 Schizosaccharomyces pombe (fission yeast) XP_791532.2 Strongylocentrotus purpuratus (purple sea urchin) 50000 Trichoplax adhaerens (metazoa) TA13945 Theileria annulata (apicomplexan parasite) XP_971278.1 Tribolium castaneum (red flour beetle) Tc00.1047053509647.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000011328 Tetraodon nigroviridis (green spotted pufferfish) TP02_0576 Theileria parva (parasitic protozoan) 3448 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036928 Takifugu rubripes (pufferfish Takifugu) 3814.m00952 Tetrahymena thermophila (ciliate protozoa) 95540.m00037 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000030432 Xenopus tropicalis (frog) YALI0C16434g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12167 NV16127 LH19911 ISCW011552 FBgn0239005 FBgn0219398 FBgn0200045 FBgn0185942 FBgn0180084 JGI_V11_231676 FBgn0071267 FBgn0158395 FBgn0139306 FBgn0123377 FBgn0107701 FBgn0087649 CPIJ007795 BGIBMGA003451 ACYPI005580 GB17101 AGAP011105 AAEL011006 PHUM180970 GLEAN_14210
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	35268 y1 sc* v1; P{TRiP.GL00163}attP2 17317 y1 w67c23; P{EPgy2}CG11811EY03154
Harvard	- PBac{RB}CG11811e02756
VDRC	v30915 w1118; P{GD5872}v30915 v30917 w1118; P{GD5872}v30917/TM3
Genomic Clones ( 1 )
	BACR26L14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 91 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH06691 RE11961
Other clones	DPiM_GH06691
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03885 GM06119 GM08086 GM08644 LD01236 LD04908 LD05161 LD09379 LD10690 LD13007 LD37678 RE12616 RE18353 RE19284 RE23609 RE29148 RE32768 RE33379 RE33766 RE33967 RE46666 RE47626 RE49120 RE61701 RE65067 RE66284 RE69357 RE70852 RE74386 RE74741
Other clones	33143 42119 50201 55654 58520 65274 70525 78210 145922 273625 274694 282612 CK01.16B.E1 CK01.42A.F12 CK01.54C.A10 CK01.66B.D9 CK01.97B.G1 CK01.108B.H5 CK01.116D.C7 Dmel_neb_004665_0117_1220 Dmel_neb_010653_0348_0908 Dmel_neb_015543_0128_3253 EC051209 EC052204 EC053165 EC053636 EC054156 EC055594 EC056179 EC056327 EK035954 EK044333 EK049549 EK053913 EK075419 EK082131 EK092331 EK143763 EK176050 EK180959 EK191029 EK192037 EK194602 EK211634 EK232603 EK248444 EK266507 EK300521 EK302255 EK308323 EP05003 FGH121D03 FGM227E10 FGM237E07 RE01382 RP001021165 RP001021333 RP001025053
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036099 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39213
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140151 RefSeq (Proteins) • NP_648408 DDBJ / EMBL / GenBank • AAF50139 AAL48657 AY071035 BI170490 CL525877 CL525878 CZ480527 CZ480528 Entrez Gene - A searchable database of RefSeq genes. • 39213 UniProtKB/TrEMBL • Q9VTB3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Guanylate kinase (IPR008144) Guanylate kinase/L-type calcium channel (IPR008145) Guanylate kinase, sub-group (IPR017665) Guanylate kinase, conserved site (IPR020590)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64590 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036099 DroID - A comprehensive database of gene and protein interactions. • FBgn0036099 DRSC - Results from RNAi screens. • FBgn0036099 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036099 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11811-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036099 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39213 InParanoid A subset of ortholog calls from InParanoid. • AAEL011006-PA Aedes aegypti (mosquito) AGAP011105-PA Anopheles gambiae (mosquito) XP_624407.1 Apis mellifera (honey bee) XP_001944743.1 Acyrthosiphon pisum (pea aphid) At3g06200.1 Arabidopsis thaliana (wall cress) 19206 Batrachochytrium dendrobatidis (chytrid fungus) 123769 Branchiostoma floridae (lancelet) XP_001893301.1 Brugia malayi (roundworm nematode) BGIBMGA003451-PA Bombyx mori (silk worm) ENSBTAP00000019656 Bos taurus (bovine) CAL0001880 Candida albicans (a form of yeast) CN20825 Caenorhabditis brenneri (small nematode) CN24682 Caenorhabditis brenneri (small nematode) CBP02919 Caenorhabditis briggsae (nematode) CE29460 Caenorhabditis elegans (worm) ENSCAFP00000001672 Canis familiaris (dog) CAGL0K06281g Candida glabrata (haploid yeast) ENSCINP00000014171 Ciona intestinalis (sea squirt) JA07639 Caenorhabditis japonica (nematode) CMD076C Cyanidioschyzon merolae (red alga) CMI041C Cyanidioschyzon merolae (red alga) cn04155 Cryptococcus neoformans (yeast-like fungus) cgd7_2190 Cryptosporidium parvum (protozoan parasite) CPIJ007795 Culex pipens (mosquito) ENSCPOP00000014501 Cavia porcellus (guinea pig) 174270 Chlamidomonas reinhardtii (green alga) RP07555 Caenorhabditis remanei (nematode) ENSCSAVP00000004136 Ciona savignyi (sedentary tunicate) 152418 Capitella spl (polychaete worm) DDB0230100 Dictyostelium discoideum (amoeba) DEHA2G07898g Debaryomyces Hansenii (yeast) 231676 Daphnia pulex (daphnia) ENSDARP00000023640 Danio rerio (zebra fish) ENSECAP00000016942 Equus caballus (horse) NP_418105.1 Escherichia coli K12 (bacteria) XP_654104 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000023053 Gymnopilus aculeatus (mushroom) ENSGALP00000008546 Gallus gallus (chicken) GL50803_7203 Giardia lamblia (flagellated protozoan) 155295 Hypsipyla robusta (cedar shoot borer) ISCW011552-PA Ixodes scapularis (deer tick) KLLA0B01694g Kluyveromyces lactis (yeast) 143665 Lottia gigantea (owl limpet) LmjF33.1090 Leishmania major (virus) 33796 Monocosta brevicollis (choanoflagellate) ENSMODP00000031359 Monodelphis domestica (gray opossum) ENSMUSP00000099763 Mus musculus (house mouse) 205628 Nematostella vectensis (starlet anemone) XP_001601528.1 Nasonia vitripennis (wasp) ENSOANP00000023348 Ornithorynchus anatinus (platypus) ENSORLP00000021996 Oryzias latipes (japanese killifish) LOC_Os12g33100.1 Oryza sativa (asian rice) 23005 Ostreococcus tauri (green alga) PFI1420w Plasmodium falciparum (protozoal parasite) PHUM000217-PA Pediculus humanus (human body louse) PP23284 Pristionchus pacificus (nematode) 148828 Physcomitrella patens (moss) ENSPPYP00000000143 Pongo pygmaeus (orangutan) 652750 Populus trichocarpa (black cottonwood) PVX_099895 Plasmodium vivax (protozoal parasite) ENSRNOP00000003926 Rattus norvegicus (norway rat) 4989453 Sorghum bicolor (sorghum) YDR454C Saccharomyces cerevisiae (budding yeast) Smp_137940 Schistosoma mansoni (trematode parasite) SPBC1198.05 Schizosaccharomyces pombe (fission yeast) XP_791532.2 Strongylocentrotus purpuratus (purple sea urchin) 50000 Trichoplax adhaerens (metazoa) TA13945 Theileria annulata (apicomplexan parasite) XP_971278.1 Tribolium castaneum (red flour beetle) Tc00.1047053509647.70 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000011328 Tetraodon nigroviridis (green spotted pufferfish) TP02_0576 Theileria parva (parasitic protozoan) 3448 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036928 Takifugu rubripes (pufferfish Takifugu) 3814.m00952 Tetrahymena thermophila (ciliate protozoa) 95540.m00037 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000030432 Xenopus tropicalis (frog) YALI0C16434g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39213 modMine - Data generated by the modENCODE project. • FBgn0036099 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12167 NV16127 LH19911 ISCW011552 FBgn0239005 FBgn0219398 FBgn0200045 FBgn0185942 FBgn0180084 JGI_V11_231676 FBgn0071267 FBgn0158395 FBgn0139306 FBgn0123377 FBgn0107701 FBgn0087649 CPIJ007795 BGIBMGA003451 ACYPI005580 GB17101 AGAP011105 AAEL011006 PHUM180970 GLEAN_14210
Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	CG11811 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19)
Name Synonym
Secondary FlyBase IDs
References ( 15 )
Research paper	Asha et al., 2003, Genetics 163(1): 203--215 Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. Genomic mapping of Exelixis insertion collection. [FBrf0184340] Gene Disruption Project members, 2001-, [title not yet available] [title not yet available] [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]