General Information Symbol Dmel\ CG11811Species D. melanogaster Name Annotation symbol CG11811 Feature type protein_coding_gene FlyBase ID FBgn0036099 Gene Model Status Current Stock availability 5 publicly
available Genomic Location Chromosome (arm) 3L Recombination map Cytogenetic map 67E6-67E7 Sequence location 3L:10,684,124..10,685,698 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information This gene is referred to in FlyBase by the symbol
Dmel\CG11811 (FBgn0036099). It is a protein_coding_gene from
Drosophila melanogaster . Based on sequence similarity, it is predicted to have
molecular function : guanylate kinase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the
biological process : purine nucleotide metabolic process.
6 alleles are reported . The
phenotype of these alleles is annotated with: trichogen cell. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: Guanylate kinase; Guanylate kinase, conserved site; Guanylate kinase, sub-group; Guanylate kinase/L-type calcium channel. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 and 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640421_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11811. Gene sequence location is
3L:10684124..10685698 .
User Contributed Data
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FB2013_03
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.45
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
(541.6)
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
397.15
Larval Midgut
215.1
Larval Hindgut
318.4
Larval Malpighian Tubules
192.3
Larval Fat Body
384
Larval Salivary Gland
441.6
Larval Trachea
367.4
Larval Carcass
509.425
Adult Head
148.2
Adult Eye
130.275
Adult Brain
152.2
Adult Thoracic-Abdominal Ganglion
141.8
Adult Crop
276.8
Adult Midgut
117.7
Adult Hindgut
137.3
Adult Malpighian Tubules
127.1
Adult Fat Body
251.7
Adult Salivary Gland
151.5
Adult Heart
156.775
Adult VirginFemale Spermatheca
122.8
Adult InseminatedFemale Spermatheca
148.4
Adult Ovary
541.6
Adult Testis
65.8
Adult Male Accessory Gland
119.2
Adult Carcass
158.7
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
148.2
NA
Eye
130.275
NA
Brain
152.2
397.15
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
141.8
NA
Crop
276.8
215.1
Midgut
117.7
318.4
Hindgut
137.3
192.3
Malpighian Tubules
127.1
384
Fat Body
251.7
441.6
Salivary Gland
151.5
NA
Heart
156.775
367.4
Trachea
NA
NA
VirginFemale Spermatheca
122.8
NA
InseminatedFemale Spermatheca
148.4
NA
Ovary
541.6
NA
Testis
65.8
NA
Male Accessory Gland
119.2
509.425
Carcass
158.7
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
86
ovary, mated 4-day female
79
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
(86)
ovary, mated 4-day female
(79)
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
86
ovary, mated 4-day female
79
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
86
ovary, mated 4-day female
79
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
86
ovary, mated 4-day female
79
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
(86)
ovary, mated 4-day female
(79)
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
86
ovary, mated 4-day female
79
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
21
central nervous system, larvae L3
20
central nervous system, pupae P8
20
head, virgin 1-day female
12
head, virgin 4-day female
11
head, virgin 20-day female
7
head, mated 1-day female
8
head, mated 4-day female
10
head, mated 20-day female
5
head, mated 1-day male
12
head, mated 4-day male
16
head, mated 20-day male
17
salivary gland, larvae L3 wandering
10
salivary gland, white prepupae
10
digestive system, larvae L3 wandering
14
digestive system, 1-day adult
11
digestive system, 4-day adult
13
digestive system, 20-day adult
8
fat body, larvae L3 wandering
14
fat body, white prepupae
10
fat body, pupae P8
9
carcass, larvae L3 wandering
24
carcass, 1-day adult
9
carcass, 4-day adult
12
carcass, 20-day adult
8
ovary, virgin 4-day female
86
ovary, mated 4-day female
79
testis, mated 4-day male
12
accessory gland, mated 4-day male
6
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
73
embryo 02-04hr
51
embryo 04-06hr
32
embryo 06-08hr
41
embryo 08-10hr
52
embryo 10-12hr
71
embryo 12-14hr
51
embryo 14-16hr
40
embryo 16-18hr
41
embryo 18-20hr
43
embryo 20-22hr
72
embryo 22-24hr
71
larva L1
54
larva L2
39
larva L3 12hr old
41
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
48
adult female 30day
48
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(73)
embryo 02-04hr
(51)
embryo 04-06hr
(32)
embryo 06-08hr
(41)
embryo 08-10hr
(52)
embryo 10-12hr
(71)
embryo 12-14hr
(51)
embryo 14-16hr
(40)
embryo 16-18hr
(41)
embryo 18-20hr
(43)
embryo 20-22hr
(72)
embryo 22-24hr
(71)
larva L1
(54)
larva L2
(39)
larva L3 12hr old
(41)
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
(32)
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
(48)
adult female 30day
(48)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
73
embryo 02-04hr
51
embryo 04-06hr
32
embryo 06-08hr
41
embryo 08-10hr
52
embryo 10-12hr
71
embryo 12-14hr
51
embryo 14-16hr
40
embryo 16-18hr
41
embryo 18-20hr
43
embryo 20-22hr
72
embryo 22-24hr
71
larva L1
54
larva L2
39
larva L3 12hr old
41
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
48
adult female 30day
48
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
73
embryo 02-04hr
51
embryo 04-06hr
32
embryo 06-08hr
41
embryo 08-10hr
52
embryo 10-12hr
71
embryo 12-14hr
51
embryo 14-16hr
40
embryo 16-18hr
41
embryo 18-20hr
43
embryo 20-22hr
72
embryo 22-24hr
71
larva L1
54
larva L2
39
larva L3 12hr old
41
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
48
adult female 30day
48
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
73
embryo 02-04hr
51
embryo 04-06hr
32
embryo 06-08hr
41
embryo 08-10hr
52
embryo 10-12hr
71
embryo 12-14hr
51
embryo 14-16hr
40
embryo 16-18hr
41
embryo 18-20hr
43
embryo 20-22hr
72
embryo 22-24hr
71
larva L1
54
larva L2
39
larva L3 12hr old
41
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
48
adult female 30day
48
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(73)
embryo 02-04hr
(51)
embryo 04-06hr
32
embryo 06-08hr
(41)
embryo 08-10hr
(52)
embryo 10-12hr
(71)
embryo 12-14hr
(51)
embryo 14-16hr
(40)
embryo 16-18hr
(41)
embryo 18-20hr
(43)
embryo 20-22hr
(72)
embryo 22-24hr
(71)
larva L1
(54)
larva L2
(39)
larva L3 12hr old
(41)
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
(48)
adult female 30day
(48)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
73
embryo 02-04hr
51
embryo 04-06hr
32
embryo 06-08hr
41
embryo 08-10hr
52
embryo 10-12hr
71
embryo 12-14hr
51
embryo 14-16hr
40
embryo 16-18hr
41
embryo 18-20hr
43
embryo 20-22hr
72
embryo 22-24hr
71
larva L1
54
larva L2
39
larva L3 12hr old
41
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
48
adult female 30day
48
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
73
embryo 02-04hr
51
embryo 04-06hr
32
embryo 06-08hr
41
embryo 08-10hr
52
embryo 10-12hr
71
embryo 12-14hr
51
embryo 14-16hr
40
embryo 16-18hr
41
embryo 18-20hr
43
embryo 20-22hr
72
embryo 22-24hr
71
larva L1
54
larva L2
39
larva L3 12hr old
41
larva L3 puffstage 1-2
17
larva L3 puffstage 3-6
21
larva L3 puffstage 7-9
23
white prepupae new
22
white prepupae 12hr
19
white prepupae 24hr
19
pupae 2d postWPP
25
pupae 3d postWPP
20
pupae 4d postWPP
32
adult male 01day
10
adult male 05day
9
adult male 30day
9
adult female 01day
26
adult female 05day
48
adult female 30day
48
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
43
Schneider line 2 Sg4
47
embryonic 1182-4H
37
embryonic GM2
30
embryonic Kc167
47
embryonic S1
30
embryonic S3
44
leg disc CME L1
31
wing disc CME-W2
62
wing disc ML-DmD8
38
wing disc ML-DmD9
39
wing disc ML-DmD16-c3
39
wing disc ML-DmD21
84
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
41
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
91
mixed discs ML-DmD4-c1
47
CNS ML-DmBG1-c1
46
CNS ML-DmBG2-c2
59
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(43)
Schneider line 2 Sg4
(47)
embryonic 1182-4H
(37)
embryonic GM2
(30)
embryonic Kc167
(47)
embryonic S1
(30)
embryonic S3
(44)
leg disc CME L1
(31)
wing disc CME-W2
(62)
wing disc ML-DmD8
(38)
wing disc ML-DmD9
(39)
wing disc ML-DmD16-c3
(39)
wing disc ML-DmD21
(84)
wing disc ML-DmD32
(27)
haltere disc ML-DmD17-c3
(41)
eye-antennal disc ML-DmD11
(29)
antennal disc ML-DmD20-c5
(91)
mixed discs ML-DmD4-c1
(47)
CNS ML-DmBG1-c1
(46)
CNS ML-DmBG2-c2
(59)
tumorous blood cells mbn2
(28)
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
43
Schneider line 2 Sg4
47
embryonic 1182-4H
37
embryonic GM2
30
embryonic Kc167
47
embryonic S1
30
embryonic S3
44
leg disc CME L1
31
wing disc CME-W2
62
wing disc ML-DmD8
38
wing disc ML-DmD9
39
wing disc ML-DmD16-c3
39
wing disc ML-DmD21
84
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
41
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
91
mixed discs ML-DmD4-c1
47
CNS ML-DmBG1-c1
46
CNS ML-DmBG2-c2
59
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
43
Schneider line 2 Sg4
47
embryonic 1182-4H
37
embryonic GM2
30
embryonic Kc167
47
embryonic S1
30
embryonic S3
44
leg disc CME L1
31
wing disc CME-W2
62
wing disc ML-DmD8
38
wing disc ML-DmD9
39
wing disc ML-DmD16-c3
39
wing disc ML-DmD21
84
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
41
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
91
mixed discs ML-DmD4-c1
47
CNS ML-DmBG1-c1
46
CNS ML-DmBG2-c2
59
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
43
Schneider line 2 Sg4
47
embryonic 1182-4H
37
embryonic GM2
30
embryonic Kc167
47
embryonic S1
30
embryonic S3
44
leg disc CME L1
31
wing disc CME-W2
62
wing disc ML-DmD8
38
wing disc ML-DmD9
39
wing disc ML-DmD16-c3
39
wing disc ML-DmD21
84
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
41
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
91
mixed discs ML-DmD4-c1
47
CNS ML-DmBG1-c1
46
CNS ML-DmBG2-c2
59
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(43)
Schneider line 2 Sg4
(47)
embryonic 1182-4H
(37)
embryonic GM2
30
embryonic Kc167
(47)
embryonic S1
30
embryonic S3
(44)
leg disc CME L1
31
wing disc CME-W2
(62)
wing disc ML-DmD8
(38)
wing disc ML-DmD9
(39)
wing disc ML-DmD16-c3
(39)
wing disc ML-DmD21
(84)
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
(41)
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
(91)
mixed discs ML-DmD4-c1
(47)
CNS ML-DmBG1-c1
(46)
CNS ML-DmBG2-c2
(59)
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
43
Schneider line 2 Sg4
47
embryonic 1182-4H
37
embryonic GM2
30
embryonic Kc167
47
embryonic S1
30
embryonic S3
44
leg disc CME L1
31
wing disc CME-W2
62
wing disc ML-DmD8
38
wing disc ML-DmD9
39
wing disc ML-DmD16-c3
39
wing disc ML-DmD21
84
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
41
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
91
mixed discs ML-DmD4-c1
47
CNS ML-DmBG1-c1
46
CNS ML-DmBG2-c2
59
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
43
Schneider line 2 Sg4
47
embryonic 1182-4H
37
embryonic GM2
30
embryonic Kc167
47
embryonic S1
30
embryonic S3
44
leg disc CME L1
31
wing disc CME-W2
62
wing disc ML-DmD8
38
wing disc ML-DmD9
39
wing disc ML-DmD16-c3
39
wing disc ML-DmD21
84
wing disc ML-DmD32
27
haltere disc ML-DmD17-c3
41
eye-antennal disc ML-DmD11
29
antennal disc ML-DmD20-c5
91
mixed discs ML-DmD4-c1
47
CNS ML-DmBG1-c1
46
CNS ML-DmBG2-c2
59
tumorous blood cells mbn2
28
ovary fGS/OSS
15
ovary OSC
13
ovary OSS
23
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
34
Cadmium 100 mM 48 hrs, 4-day adult
55
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
65
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
33
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
47
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
36
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
(28)
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
(34)
Cadmium 100 mM 48 hrs, 4-day adult
(55)
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
(65)
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
(33)
Ethanol 5% 3 hrs, larvae L3
(29)
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(47)
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
(36)
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
(29)
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
34
Cadmium 100 mM 48 hrs, 4-day adult
55
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
65
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
33
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
47
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
36
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
34
Cadmium 100 mM 48 hrs, 4-day adult
55
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
65
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
33
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
47
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
36
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
34
Cadmium 100 mM 48 hrs, 4-day adult
55
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
65
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
33
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
47
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
36
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
(34)
Cadmium 100 mM 48 hrs, 4-day adult
(55)
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
(65)
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
(33)
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(47)
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
(36)
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
34
Cadmium 100 mM 48 hrs, 4-day adult
55
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
65
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
33
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
47
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
36
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
15
cold shock, 4-day adult
13
heat shock, 4-day adult
28
Cadmium 50 mM 6 hrs, larvae L3
25
Cadmium 50 mM 12 hrs, larvae L3
22
Cadmium 50 mM 48 hrs, 4-day adult
34
Cadmium 100 mM 48 hrs, 4-day adult
55
Copper 0.5 mM 12 hrs, larvae L3
16
Copper 15 mM 48 hrs, 4-day adult
65
Zinc 5 mM 12 hrs, larvae L3
20
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
33
Ethanol 5% 3 hrs, larvae L3
29
Ethanol 10% 3 hrs, larvae L3
23
Caffeine 1.5 mg/ml 4 hrs, larvae L3
15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
47
Caffeine 25 mg/ml 48 hrs, 4-day adult
16
Paraquat 5 mM 48 hrs, 4-day adult
36
Paraquat 10 mM 48 hrs, 4-day adult
25
Rotenone 2 μg 12 hrs, larvae L3
29
Rotenone 8 μg 12 hrs, larvae L3
22
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 2 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 4 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Transgenic Constructs & Insertions
Transgenic Constructs Insertions insertion of mobile activating element
Gene Ontology: Function, Process
& Cellular Component ( 2 unique terms ) Terms Based on
Experimental Evidence ( 0 terms ) Terms Based on Predictions or
Assertions ( 2 terms ) Molecular Function Biological Process Cellular Component ( 0 terms) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
anti tag coimmunoprecipitation, peptide massfingerprinting
anti tag coimmunoprecipitation, peptide massfingerprinting
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (40)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG64QTMC )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6Z36PX )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6Z8WSS )
Apis mellifera
Western honey bee
Amel\GB46787
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013143
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH13791
Atta cephalotes
Leafcutter ant
Acep\ACEP19237
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO14352
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL16955
Linepithema humile
Argentine ant
Lhum\LH19911
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB12167
Solenopsis invicta
Red fire ant
Sinv\SINV13072
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG66M91W )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG618QHG )
Caenorhabditis elegans
Nematode
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 5 )Bloomington Harvard VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 91 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Additional comments Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- DPiM, Drosophila Protein interaction Map
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 1 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 20 )Research paper Asha et al., 2003, Genetics 163(1): 203--215Analysis of ras-induced overproliferation in Drosophila hemocytes. [FBrf0155813] Supplementary material Graveley et al., 2011, Nature 471(7339): Supplementary Table 33. Fuzzy Cluster Members. [FBrf0213980] Guruharsha et al., 2011, Cell 147(3): Table S3. [FBrf0218395] The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452] Personal communication to FlyBase Ni et al., 2011.7.19, TRiP germline vector pVALIUM21.TRiP germline vector pVALIUM21. [FBrf0214641] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Mintseris et al., 2009.11.23, DPiM: the Drosophila Protein Interaction Mapping projectDPiM: the Drosophila Protein Interaction Mapping project [FBrf0209452] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi CenterRNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Gene Disruption Project members and Exelixis, 2005, Genomic mapping of Exelixis insertion collection. (Computer file)Genomic mapping of Exelixis insertion collection. (Computer file) [FBrf0184340] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215] Gene Disruption Project members, 2001-, (Computer file)(Computer file) [FBrf0132177] BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. (Computer file)Berkeley Drosophila Genome Project. (Computer file) [FBrf0125078] FlyBase analysis FlyBase, 1992-, FlyBase curation.FlyBase curation. [FBrf0105495] Stock list Japanese National Institute of Genetics, 2012.5.21, RNAi stocks available from NIG-FLY.RNAi stocks available from NIG-FLY. [FBrf0218457] Website Fisher et al., 2012, BDGP insitu homepageBDGP insitu homepage [FBrf0219073] Curated genome annotation Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.][Annotations performed at the Celera Jamboreee.] [FBrf0126651] FamiliarityBreedsContempt, 1999.11, [Automatic annotations performed at the Celera Jamboreee.][Automatic annotations performed at the Celera Jamboreee.] [FBrf0126705]