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Gene Dmel\CG6272

General Information
Symbol	Dmel\CG6272	Species	D. melanogaster
Name		Annotation symbol	CG6272
Feature type	protein_coding_gene	FlyBase ID	FBgn0036126
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	68A6-68A6	Sequence location	3L:11,090,546..11,091,286 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG6272 (FBgn0036126). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Basic-leucine zipper domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628683_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG6272. Gene sequence location is 3L:11090546..11091286.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68A6-68A6   Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG6272 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Gene model reviewed during 5.44
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG6272-RA FBtr0076234  NM_140177   543   113 CG6272-RB FBtr0332706  NM_001274769   614   113
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG6272-PA   FBpp0075963   13.0   113   9.84     NP_648434   AAF50103 CG6272-PB   FBpp0304952   13.0   113   9.84     NP_001261698   AGB94392
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper domain (IPR004827)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50103   AE014296 AGB94392   AI114193   AY118768 AAM50628   BP559080   CZ487595   EV592941
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VTE8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    137.925 Larval Midgut    111.2 Larval Hindgut    204.5 Larval Malpighian Tubules    264.8 Larval Fat Body    139.1 Larval Salivary Gland    148.3 Larval Trachea    245.25 Larval Carcass    174.075 Adult Head    181.9 Adult Eye    310.825 Adult Brain    164.2 Adult Thoracic-Abdominal Ganglion    163.3 Adult Crop    218.1 Adult Midgut    105.5 Adult Hindgut    175.6 Adult Malpighian Tubules    165.5 Adult Fat Body    140.4 Adult Salivary Gland    261 Adult Heart    223 Adult VirginFemale Spermatheca    116.7 Adult InseminatedFemale Spermatheca    118.6 Adult Ovary    113.9 Adult Testis    28.6 Adult Male Accessory Gland    162 Adult Carcass    148.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    181.9   NA  Eye    310.825   NA  Brain    164.2   137.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    163.3   NA  Crop    218.1   111.2  Midgut    105.5   204.5  Hindgut    175.6   264.8  Malpighian Tubules    165.5   139.1  Fat Body    140.4   148.3  Salivary Gland    261   NA  Heart    223   245.25  Trachea    NA   NA  VirginFemale Spermatheca    116.7   NA  InseminatedFemale Spermatheca    118.6   NA  Ovary    113.9   NA  Testis    28.6   NA  Male Accessory Gland    162   174.075  Carcass    148.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    30 head, virgin 20-day female    13 head, mated 1-day female    37 head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    44 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    37 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae    31 fat body, pupae P8    27 carcass, larvae L3 wandering    24 carcass, 1-day adult    29 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female  (30) head, virgin 20-day female    13 head, mated 1-day female  (37) head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male  (33) head, mated 4-day male  (33) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering  (37) digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae  (31) fat body, pupae P8  (27) carcass, larvae L3 wandering    24 carcass, 1-day adult  (29) carcass, 4-day adult  (27) carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    30 head, virgin 20-day female    13 head, mated 1-day female    37 head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    44 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    37 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae    31 fat body, pupae P8    27 carcass, larvae L3 wandering    24 carcass, 1-day adult    29 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    30 head, virgin 20-day female    13 head, mated 1-day female    37 head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    44 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    37 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae    31 fat body, pupae P8    27 carcass, larvae L3 wandering    24 carcass, 1-day adult    29 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    30 head, virgin 20-day female    13 head, mated 1-day female    37 head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    44 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    37 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae    31 fat body, pupae P8    27 carcass, larvae L3 wandering    24 carcass, 1-day adult    29 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female  30 head, virgin 20-day female    13 head, mated 1-day female  (37) head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male  (33) head, mated 4-day male  (33) head, mated 20-day male  (44) salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering  (37) digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae  31 fat body, pupae P8  27 carcass, larvae L3 wandering    24 carcass, 1-day adult  29 carcass, 4-day adult  27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    30 head, virgin 20-day female    13 head, mated 1-day female    37 head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    44 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    37 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae    31 fat body, pupae P8    27 carcass, larvae L3 wandering    24 carcass, 1-day adult    29 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    11 central nervous system, larvae L3    18 central nervous system, pupae P8    18 head, virgin 1-day female    24 head, virgin 4-day female    30 head, virgin 20-day female    13 head, mated 1-day female    37 head, mated 4-day female    23 head, mated 20-day female    17 head, mated 1-day male    33 head, mated 4-day male    33 head, mated 20-day male    44 salivary gland, larvae L3 wandering    20 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    37 digestive system, 1-day adult    16 digestive system, 4-day adult    14 digestive system, 20-day adult    12 fat body, larvae L3 wandering    15 fat body, white prepupae    31 fat body, pupae P8    27 carcass, larvae L3 wandering    24 carcass, 1-day adult    29 carcass, 4-day adult    27 carcass, 20-day adult    24 ovary, virgin 4-day female    23 ovary, mated 4-day female    25 testis, mated 4-day male    13 accessory gland, mated 4-day male    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 06-24 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    13 embryo 02-04hr    8 embryo 04-06hr    13 embryo 06-08hr    15 embryo 08-10hr    19 embryo 10-12hr    23 embryo 12-14hr    21 embryo 14-16hr    10 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    12 embryo 22-24hr    19 larva L1    6 larva L2    8 larva L3 12hr old    8 larva L3 puffstage 1-2    12 larva L3 puffstage 3-6    15 larva L3 puffstage 7-9    24 white prepupae new    20 white prepupae 12hr    24 white prepupae 24hr    18 pupae 2d postWPP    21 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    16 adult male 05day    13 adult male 30day    8 adult female 01day    8 adult female 05day    14 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    148 Schneider line 2 Sg4    44 embryonic 1182-4H    67 embryonic GM2    101 embryonic Kc167    261 embryonic S1    78 embryonic S3    35 leg disc CME L1    65 wing disc CME-W2    145 wing disc ML-DmD8    59 wing disc ML-DmD9    55 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    90 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    81 ovary fGS/OSS    89 ovary OSC    127 ovary OSS    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (148) Schneider line 2 Sg4  (44) embryonic 1182-4H  (67) embryonic GM2  (101) embryonic Kc167  (261) embryonic S1  (78) embryonic S3  (35) leg disc CME L1  (65) wing disc CME-W2  (145) wing disc ML-DmD8  (59) wing disc ML-DmD9  (55) wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (90) wing disc ML-DmD32  (62) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11  (55) antennal disc ML-DmD20-c5  (69) mixed discs ML-DmD4-c1  (82) CNS ML-DmBG1-c1  (86) CNS ML-DmBG2-c2  (99) tumorous blood cells mbn2  (81) ovary fGS/OSS  (89) ovary OSC  (127) ovary OSS  (76) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (148) Schneider line 2 Sg4    44 embryonic 1182-4H    67 embryonic GM2  101 embryonic Kc167  (261) embryonic S1    78 embryonic S3    35 leg disc CME L1    65 wing disc CME-W2  (145) wing disc ML-DmD8    59 wing disc ML-DmD9    55 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    90 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    81 ovary fGS/OSS    89 ovary OSC  (127) ovary OSS    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    148 Schneider line 2 Sg4    44 embryonic 1182-4H    67 embryonic GM2    101 embryonic Kc167    261 embryonic S1    78 embryonic S3    35 leg disc CME L1    65 wing disc CME-W2    145 wing disc ML-DmD8    59 wing disc ML-DmD9    55 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    90 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    81 ovary fGS/OSS    89 ovary OSC    127 ovary OSS    76 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    148 Schneider line 2 Sg4    44 embryonic 1182-4H    67 embryonic GM2    101 embryonic Kc167    261 embryonic S1    78 embryonic S3    35 leg disc CME L1    65 wing disc CME-W2    145 wing disc ML-DmD8    59 wing disc ML-DmD9    55 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    90 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    81 ovary fGS/OSS    89 ovary OSC    127 ovary OSS    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (148) Schneider line 2 Sg4  (44) embryonic 1182-4H  (67) embryonic GM2  (101) embryonic Kc167  (261) embryonic S1  (78) embryonic S3  (35) leg disc CME L1  (65) wing disc CME-W2  (145) wing disc ML-DmD8  (59) wing disc ML-DmD9  (55) wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (90) wing disc ML-DmD32  (62) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11  (55) antennal disc ML-DmD20-c5  (69) mixed discs ML-DmD4-c1  (82) CNS ML-DmBG1-c1  (86) CNS ML-DmBG2-c2  (99) tumorous blood cells mbn2  (81) ovary fGS/OSS  (89) ovary OSC  (127) ovary OSS  (76) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (148) Schneider line 2 Sg4    44 embryonic 1182-4H    67 embryonic GM2  101 embryonic Kc167  (261) embryonic S1    78 embryonic S3    35 leg disc CME L1    65 wing disc CME-W2  (145) wing disc ML-DmD8    59 wing disc ML-DmD9    55 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    90 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    81 ovary fGS/OSS    89 ovary OSC  127 ovary OSS    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    148 Schneider line 2 Sg4    44 embryonic 1182-4H    67 embryonic GM2    101 embryonic Kc167    261 embryonic S1    78 embryonic S3    35 leg disc CME L1    65 wing disc CME-W2    145 wing disc ML-DmD8    59 wing disc ML-DmD9    55 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    90 wing disc ML-DmD32    62 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    55 antennal disc ML-DmD20-c5    69 mixed discs ML-DmD4-c1    82 CNS ML-DmBG1-c1    86 CNS ML-DmBG2-c2    99 tumorous blood cells mbn2    81 ovary fGS/OSS    89 ovary OSC    127 ovary OSS    76 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3  (31) Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (27) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (32) Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3  (34) Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3  26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (29) Paraquat 10 mM 48 hrs, 4-day adult  (31) Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3  31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult  (35) Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3  (34) Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3  26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  29 Paraquat 10 mM 48 hrs, 4-day adult  31 Rotenone 2 μg 12 hrs, larvae L3  26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    12 heat shock, 4-day adult    17 Cadmium 50 mM 6 hrs, larvae L3    16 Cadmium 50 mM 12 hrs, larvae L3    31 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    27 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    32 Zinc 5 mM 12 hrs, larvae L3    21 Zinc 4.5 mM 48 hrs, 4-day adult    35 Ethanol 2.5% 3 hrs, larvae L3    13 Ethanol 5% 3 hrs, larvae L3    34 Ethanol 10% 3 hrs, larvae L3    15 Caffeine 1.5 mg/ml 4 hrs, larvae L3    26 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    31 Rotenone 2 μg 12 hrs, larvae L3    26 Rotenone 8 μg 12 hrs, larvae L3    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_09
External Data & Images
Linkouts	BDGP expression data • GH10915 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036126 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6272-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal CG6272GD10567 lethal | pupal stage, with Scer\GAL4pnr-MD237 CG6272GD10567 Other Phenotypes Allele neuroanatomy defective | larval stage CG6272GD10567 Phenotype manifest in Allele ganglion mother cell | larval stage CG6272GD10567
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG6272 Class Mutagen Stocks Known lesion CG6272f05006 piggyBac transposase 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG6272 Class Mutagen Stocks Known lesion CG6272GD10567 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes CG6272HMS00057 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6272JF02493 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CG6272KK110056 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10567} NA P{KK110056} NA P{TRiP.HMS00057} NA P{TRiP.JF02493} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}pncr011:3LKG00249 NA PBac{WH}CG6272f05006 NA insertion of enhancer trap binary system P{GAL4}laska1 No insertion of mobile activating element P{EPg}APP-BP1HP32076 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from sequence or structural similarity (Fassler et al., 2002) sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR011700 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR011700 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR004827, InterPro:IPR011700 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
CG6272 - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG13472 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG3862 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG43444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG7194 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - CG7903 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - FLASH anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Ip259 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Nop56 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Psi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - RpL35A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - RpS12 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - RpS27A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - SF1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Snr1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Syp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - U2A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - U4-U6-60K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - larp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - mars anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - mod(mdg4) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - mor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - ppan anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - qkr54B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - snama anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) CG6272 - vkg anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG6272 allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036126 DroID - A comprehensive database of gene and protein interactions. • FBgn0036126
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FFDNK Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6FFDNK)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\CG6272     Drosophila simulans   Dsim\GD12828 Y   Drosophila sechellia   Dsec\GM24777 Y   Drosophila erecta   Dere\GG13942 Y   Drosophila yakuba   Dyak\GE20240 Y   Drosophila ananassae   Dana\GF10550 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19480 Y   Drosophila persimilis   Dper\GL24916 Y   Drosophila willistoni   Dwil\GK12307 Y   Drosophila virilis   Dvir\GJ11967 Y   Drosophila mojavensis   Dmoj\GI13192 Y   Drosophila grimshawi   Dgri\GH16258 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12828 Drosophila sechellia Dsec\GM24777 Drosophila erecta Dere\GG13942 Drosophila yakuba Dyak\GE20240 Drosophila ananassae Dana\GF10550 Drosophila pseudoobscura pseudoobscura Dpse\GA19480 Drosophila persimilis Dper\GL24916 Drosophila willistoni Dwil\GK12307 Drosophila virilis Dvir\GJ11967 Drosophila mojavensis Dmoj\GI13192 Drosophila grimshawi Dgri\GH16258
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	29331 y1 v1; P{TRiP.JF02493}attP2 33652 y1 sc* v1; P{TRiP.HMS00057}attP2
Harvard	- PBac{WH}CG6272f05006
VDRC	v101871 P{KK110056}VIE-260B v34156 w1118; P{GD10567}v34156 v34158 w1118; P{GD10567}v34158
Genomic Clones ( 1 )
	BACR48O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH10915
Other clones	DPiM_GH10915
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	Dmel_neb_015028_0657_0349 FGM318G08
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036126 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39243
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: CG6272 BcDNA:GH10915 (FlyBase, 1996-)
Additional comments	Source for merge of CG6272 BcDNA:GH10915 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140177 NM_001274769 RefSeq (Proteins) • NP_648434 NP_001261698 DDBJ / EMBL / GenBank • AAF50103 AAM50628 AGB94392 AI114193 AY118768 CZ487595 Entrez Gene - A searchable database of RefSeq genes. • 39243 UniProtKB/TrEMBL • Q9VTE8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Basic-leucine zipper domain (IPR004827) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH10915
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036126 DroID - A comprehensive database of gene and protein interactions. • FBgn0036126 DRSC - Results from RNAi screens. • FBgn0036126 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036126 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6272-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036126 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39243 modMine - Data generated by the modENCODE project. • FBgn0036126
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	BcDNA:GH10915   CG6272 (Gruenewald et al., 2009, Akdemir et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Zhou et al., 2008, Ni et al., 2010.12.1, Neumüller et al., 2011) CT19628 (Ceriani et al., 2002)
Name Synonym
Secondary FlyBase IDs
	FBgn0063258
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...