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Gene Dmel\mRpL2

General Information
Symbol	Dmel\mRpL2	Species	D. melanogaster
Name	mitochondrial ribosomal protein L2	Annotation symbol	CG7636
Feature type	protein_coding_gene	FlyBase ID	FBgn0036135
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	68A7-68A7	Sequence location	3L:11,113,959..11,115,141 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ribosomal protein L2 is referred to in FlyBase by the symbol Dmel\mRpL2 (CG7636, FBgn0036135). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 2 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Nucleic acid-binding, OB-fold; Nucleic acid-binding, OB-fold-like; Ribosomal Proteins L2, RNA binding domain; Ribosomal protein L2; Ribosomal protein L2, C-terminal; Translation protein SH3-like; Translation protein SH3-like, subgroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624278_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpL2. Gene sequence location is 3L:11113959..11115141.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Casad et al., 2011, Genetics 189(3): 861--870 Sequence features HFA10896 BKN27528 BKN45454
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68A7-68A7   Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mRpL2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.42
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mRpL2-RA FBtr0076211  NM_079298   1027   294
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mRpL2-PA   FBpp0075941   32.8   294   11.06     NP_524022   AAF50091
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L2 (IPR002171) Translation protein SH3-like (IPR008991) Translation protein SH3-like, subgroup (IPR014722) Nucleic acid-binding, OB-fold-like (IPR016027) Ribosomal Proteins L2, RNA binding domain (IPR022666) Ribosomal protein L2, C-terminal (IPR022669) Nucleic acid-binding, OB-fold (IPR012340)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50091   AY113486 AAM29491   BF504253   BG634721   BI216384   BI243509   BI361291   BT044326   CO177923   EC267141   EL874138   EL874263   EV588066   EV593105   EV597000   EV597421   EV597892   EV600257
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MYY5 Q9VTF8
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0036135    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0036135 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0036135 expression level Developmental Stage   Expression Level embryo 00-02hr    3047 embryo 02-04hr    3868 embryo 04-06hr    4399 embryo 06-08hr    4256 embryo 08-10hr    3992 embryo 10-12hr    6407 embryo 12-14hr    3397 embryo 14-16hr    5703 embryo 16-18hr    4887 embryo 18-20hr    4954 embryo 20-22hr    4355 embryo 22-24hr    3203 larva L1    6341 larva L2    6016 larva L3 12hr old    4759 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    1690 larva L3 puffstage 7-9    1429 white prepupae new    1440 white prepupae 12hr    1548 white prepupae 24hr    1968 pupae 2d postWPP    2832 pupae 3d postWPP    4101 pupae 4d postWPP    2441 adult male 01day    2119 adult male 05day    2383 adult male 30day    2426 adult female 01day    3769 adult female 05day    3016 adult female 30day    3137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3047) embryo 02-04hr  (3868) embryo 04-06hr  (4399) embryo 06-08hr  (4256) embryo 08-10hr  (3992) embryo 10-12hr  (6407) embryo 12-14hr  (3397) embryo 14-16hr  (5703) embryo 16-18hr  (4887) embryo 18-20hr  (4954) embryo 20-22hr  (4355) embryo 22-24hr  (3203) larva L1  (6341) larva L2  (6016) larva L3 12hr old  (4759) larva L3 puffstage 1-2  (1641) larva L3 puffstage 3-6  (1690) larva L3 puffstage 7-9  (1429) white prepupae new  (1440) white prepupae 12hr  (1548) white prepupae 24hr  (1968) pupae 2d postWPP  (2832) pupae 3d postWPP  (4101) pupae 4d postWPP  (2441) adult male 01day  (2119) adult male 05day  (2383) adult male 30day  (2426) adult female 01day  (3769) adult female 05day  (3016) adult female 30day  (3137) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3047) embryo 02-04hr  (3868) embryo 04-06hr  (4399) embryo 06-08hr  (4256) embryo 08-10hr  (3992) embryo 10-12hr  (6407) embryo 12-14hr  (3397) embryo 14-16hr  (5703) embryo 16-18hr  (4887) embryo 18-20hr  (4954) embryo 20-22hr  (4355) embryo 22-24hr  (3203) larva L1  (6341) larva L2  (6016) larva L3 12hr old  (4759) larva L3 puffstage 1-2  (1641) larva L3 puffstage 3-6  (1690) larva L3 puffstage 7-9  1429 white prepupae new  1440 white prepupae 12hr  (1548) white prepupae 24hr  (1968) pupae 2d postWPP  (2832) pupae 3d postWPP  (4101) pupae 4d postWPP  (2441) adult male 01day  (2119) adult male 05day  (2383) adult male 30day  (2426) adult female 01day  (3769) adult female 05day  (3016) adult female 30day  (3137) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3047 embryo 02-04hr    3868 embryo 04-06hr    4399 embryo 06-08hr    4256 embryo 08-10hr    3992 embryo 10-12hr    6407 embryo 12-14hr    3397 embryo 14-16hr    5703 embryo 16-18hr    4887 embryo 18-20hr    4954 embryo 20-22hr    4355 embryo 22-24hr    3203 larva L1    6341 larva L2    6016 larva L3 12hr old    4759 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    1690 larva L3 puffstage 7-9    1429 white prepupae new    1440 white prepupae 12hr    1548 white prepupae 24hr    1968 pupae 2d postWPP    2832 pupae 3d postWPP    4101 pupae 4d postWPP    2441 adult male 01day    2119 adult male 05day    2383 adult male 30day    2426 adult female 01day    3769 adult female 05day    3016 adult female 30day    3137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3047 embryo 02-04hr    3868 embryo 04-06hr    4399 embryo 06-08hr    4256 embryo 08-10hr    3992 embryo 10-12hr    6407 embryo 12-14hr    3397 embryo 14-16hr    5703 embryo 16-18hr    4887 embryo 18-20hr    4954 embryo 20-22hr    4355 embryo 22-24hr    3203 larva L1    6341 larva L2    6016 larva L3 12hr old    4759 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    1690 larva L3 puffstage 7-9    1429 white prepupae new    1440 white prepupae 12hr    1548 white prepupae 24hr    1968 pupae 2d postWPP    2832 pupae 3d postWPP    4101 pupae 4d postWPP    2441 adult male 01day    2119 adult male 05day    2383 adult male 30day    2426 adult female 01day    3769 adult female 05day    3016 adult female 30day    3137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0036135 expression level Developmental Stage   Expression Level embryo 00-02hr    3047 embryo 02-04hr    3868 embryo 04-06hr    4399 embryo 06-08hr    4256 embryo 08-10hr    3992 embryo 10-12hr    6407 embryo 12-14hr    3397 embryo 14-16hr    5703 embryo 16-18hr    4887 embryo 18-20hr    4954 embryo 20-22hr    4355 embryo 22-24hr    3203 larva L1    6341 larva L2    6016 larva L3 12hr old    4759 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    1690 larva L3 puffstage 7-9    1429 white prepupae new    1440 white prepupae 12hr    1548 white prepupae 24hr    1968 pupae 2d postWPP    2832 pupae 3d postWPP    4101 pupae 4d postWPP    2441 adult male 01day    2119 adult male 05day    2383 adult male 30day    2426 adult female 01day    3769 adult female 05day    3016 adult female 30day    3137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3047) embryo 02-04hr  (3868) embryo 04-06hr  (4399) embryo 06-08hr  (4256) embryo 08-10hr  (3992) embryo 10-12hr  (6407) embryo 12-14hr  (3397) embryo 14-16hr  (5703) embryo 16-18hr  (4887) embryo 18-20hr  (4954) embryo 20-22hr  (4355) embryo 22-24hr  (3203) larva L1  (6341) larva L2  (6016) larva L3 12hr old  (4759) larva L3 puffstage 1-2  (1641) larva L3 puffstage 3-6  (1690) larva L3 puffstage 7-9  (1429) white prepupae new  (1440) white prepupae 12hr  (1548) white prepupae 24hr  (1968) pupae 2d postWPP  (2832) pupae 3d postWPP  (4101) pupae 4d postWPP  (2441) adult male 01day  (2119) adult male 05day  (2383) adult male 30day  (2426) adult female 01day  (3769) adult female 05day  (3016) adult female 30day  (3137) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3047) embryo 02-04hr  (3868) embryo 04-06hr  (4399) embryo 06-08hr  (4256) embryo 08-10hr  (3992) embryo 10-12hr  (6407) embryo 12-14hr  (3397) embryo 14-16hr  (5703) embryo 16-18hr  (4887) embryo 18-20hr  (4954) embryo 20-22hr  (4355) embryo 22-24hr  (3203) larva L1  (6341) larva L2  (6016) larva L3 12hr old  (4759) larva L3 puffstage 1-2  1641 larva L3 puffstage 3-6  1690 larva L3 puffstage 7-9  1429 white prepupae new  1440 white prepupae 12hr  1548 white prepupae 24hr  1968 pupae 2d postWPP  (2832) pupae 3d postWPP  (4101) pupae 4d postWPP  2441 adult male 01day  2119 adult male 05day  2383 adult male 30day  2426 adult female 01day  (3769) adult female 05day  (3016) adult female 30day  (3137) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3047 embryo 02-04hr    3868 embryo 04-06hr    4399 embryo 06-08hr    4256 embryo 08-10hr    3992 embryo 10-12hr    6407 embryo 12-14hr    3397 embryo 14-16hr    5703 embryo 16-18hr    4887 embryo 18-20hr    4954 embryo 20-22hr    4355 embryo 22-24hr    3203 larva L1    6341 larva L2    6016 larva L3 12hr old    4759 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    1690 larva L3 puffstage 7-9    1429 white prepupae new    1440 white prepupae 12hr    1548 white prepupae 24hr    1968 pupae 2d postWPP    2832 pupae 3d postWPP    4101 pupae 4d postWPP    2441 adult male 01day    2119 adult male 05day    2383 adult male 30day    2426 adult female 01day    3769 adult female 05day    3016 adult female 30day    3137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3047 embryo 02-04hr    3868 embryo 04-06hr    4399 embryo 06-08hr    4256 embryo 08-10hr    3992 embryo 10-12hr    6407 embryo 12-14hr    3397 embryo 14-16hr    5703 embryo 16-18hr    4887 embryo 18-20hr    4954 embryo 20-22hr    4355 embryo 22-24hr    3203 larva L1    6341 larva L2    6016 larva L3 12hr old    4759 larva L3 puffstage 1-2    1641 larva L3 puffstage 3-6    1690 larva L3 puffstage 7-9    1429 white prepupae new    1440 white prepupae 12hr    1548 white prepupae 24hr    1968 pupae 2d postWPP    2832 pupae 3d postWPP    4101 pupae 4d postWPP    2441 adult male 01day    2119 adult male 05day    2383 adult male 30day    2426 adult female 01day    3769 adult female 05day    3016 adult female 30day    3137 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0036135    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0036135 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0036135 expression level Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0036135 expression level Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    226.675 Larval Midgut    107.4 Larval Hindgut    167.4 Larval Malpighian Tubules    97.1 Larval Fat Body    82.1 Larval Salivary Gland    162.6 Larval Trachea    139.075 Larval Carcass    133.175 Adult Head    150.1 Adult Eye    160.625 Adult Brain    226.3 Adult Thoracic-Abdominal Ganglion    264.4 Adult Crop    159.4 Adult Midgut    149 Adult Hindgut    191.8 Adult Malpighian Tubules    121.6 Adult Fat Body    158.8 Adult Salivary Gland    143.2 Adult Heart    164.375 Adult VirginFemale Spermatheca    149.8 Adult InseminatedFemale Spermatheca    136.9 Adult Ovary    166.2 Adult Testis    89.9 Adult Male Accessory Gland    127.4 Adult Carcass    175 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    150.1   NA  Eye    160.625   NA  Brain    226.3   226.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    264.4   NA  Crop    159.4   107.4  Midgut    149   167.4  Hindgut    191.8   97.1  Malpighian Tubules    121.6   82.1  Fat Body    158.8   162.6  Salivary Gland    143.2   NA  Heart    164.375   139.075  Trachea    NA   NA  VirginFemale Spermatheca    149.8   NA  InseminatedFemale Spermatheca    136.9   NA  Ovary    166.2   NA  Testis    89.9   NA  Male Accessory Gland    127.4   133.175  Carcass    175 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036135 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7636-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mRpL2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 mRpL2GD5881 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mRpL2GD5881 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 mRpL2GD5881
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of mRpL2 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mRpL2 Class Mutagen Stocks Known lesion mRpL2GD5881 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mRpL2KK107528 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5881} NA P{KK107528} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
structural constituent of ribosome inferred from sequence or structural similarity with EMBL:AI313184 (Suzuki et al., 2001) inferred from sequence or structural similarity with UniProtKB:P38510 (FlyBase, 1992-)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with EMBL:AI313184 (Suzuki et al., 2001) inferred from sequence or structural similarity with UniProtKB:P38510 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
mitochondrial large ribosomal subunit inferred from sequence or structural similarity with EMBL:AI313184 (Suzuki et al., 2001) inferred from sequence or structural similarity with UniProtKB:P38510 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mRpL2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0036135 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39253
Orthologs
Genome-wide drosophilid orthologs	Dana\GF25244 Dere\GG15481 Dgri\GH16930 Dmoj\GI13684 Dper\GL22842 Dpse\GA20496 Dsec\GM25252 Dsim\GD14286 Dvir\GJ14025 Dwil\GK20336 Dyak\GE21791
Curated drosophilid orthologs	Dpse\GA20496
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000210-PA Aedes aegypti (mosquito) AGAP010450-PA Anopheles gambiae (mosquito) XP_625019.1 Apis mellifera (honey bee) XP_001952518.1 Acyrthosiphon pisum (pea aphid) 283896 Branchiostoma floridae (lancelet) XP_001893685.1 Brugia malayi (roundworm nematode) BGIBMGA001500-PA Bombyx mori (silk worm) ENSBTAP00000016951 Bos taurus (bovine) CN28931 Caenorhabditis brenneri (small nematode) CBP12640 Caenorhabditis briggsae (nematode) CE34320 Caenorhabditis elegans (worm) ENSCAFP00000002594 Canis familiaris (dog) ENSCINP00000010033 Ciona intestinalis (sea squirt) CMP277C Cyanidioschyzon merolae (red alga) CPIJ008796 Culex pipens (mosquito) ENSCPOP00000020146 Cavia porcellus (guinea pig) RP03126 Caenorhabditis remanei (nematode) ENSCSAVP00000009726 Ciona savignyi (sedentary tunicate) 159292 Capitella spl (polychaete worm) DEHA2E05478g Debaryomyces Hansenii (yeast) 307116 Daphnia pulex (daphnia) ENSDARP00000085077 Danio rerio (zebra fish) ENSECAP00000017830 Equus caballus (horse) ENSGACP00000005403 Gymnopilus aculeatus (mushroom) ENSGALP00000013983 Gallus gallus (chicken) 185933 Hypsipyla robusta (cedar shoot borer) ENSP00000373404 Homo sapiens (human) ISCW005878-PA Ixodes scapularis (deer tick) 213398 Lottia gigantea (owl limpet) ENSMODP00000023698 Monodelphis domestica (gray opossum) ENSMMUP00000033665 Macaca mulatta (rhesus monkey) ENSMUSP00000002844 Mus musculus (house mouse) 35830 Nematostella vectensis (starlet anemone) XP_001601775.1 Nasonia vitripennis (wasp) ENSOANP00000013436 Ornithorynchus anatinus (platypus) ENSORLP00000016135 Oryzias latipes (japanese killifish) 30408 Ostreococcus tauri (green alga) PHUM011218-PA Pediculus humanus (human body louse) PP01299 Pristionchus pacificus (nematode) ENSPPYP00000018600 Pongo pygmaeus (orangutan) ENSPTRP00000046533 Pan troglodytes (chimpanzee) ENSRNOP00000024380 Rattus norvegicus (norway rat) Smp_151770 Schistosoma mansoni (trematode parasite) XP_789607.2 Strongylocentrotus purpuratus (purple sea urchin) 26453 Trichoplax adhaerens (metazoa) XP_972108.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016419 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002152 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12625 LH21170 ISCW005878 FBgn0239036 FBgn0222333 FBgn0201243 FBgn0185971 FBgn0180112 JGI_V11_307116 FBgn0080491 FBgn0160433 FBgn0136439 FBgn0124401 FBgn0107731 FBgn0102236 CPIJ008796 BGIBMGA001500 ACYPI009104 GB14941 AGAP010450 AAEL000210 PB25789 PHUM588770 GLEAN_00434
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v101315 P{KK107528}VIE-260B v13828 w1118; P{GD5881}v13828
Genomic Clones ( 2 )
	BACR19G23 BACR48O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE45450
Other clones	FI07257
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05574 AT31032 RE23508 RE41170
Other clones	572721 Dmel_neb_007830_0879_3706 Dmel_neb_010714_0945_3153 Dmel_neb_010876_0942_2515 Dmel_neb_011436_0922_1064 Dmel_neb_013994_0593_0847 Dmel_neb_014583_0141_1535 EK054707 IP14188 IP14288
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036135 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39253
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mRpL2 CG7636 (Suzuki et al., 2001)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079298 RefSeq (Proteins) • NP_524022 DDBJ / EMBL / GenBank • AAF50091 AAM29491 AY113486 BI361291 Entrez Gene - A searchable database of RefSeq genes. • 39253 UniProtKB/TrEMBL • Q8MYY5 Q9VTF8
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L2 (IPR002171) Translation protein SH3-like (IPR008991) Translation protein SH3-like, subgroup (IPR014722) Nucleic acid-binding, OB-fold-like (IPR016027) Ribosomal Proteins L2, RNA binding domain (IPR022666) Ribosomal protein L2, C-terminal (IPR022669) Nucleic acid-binding, OB-fold (IPR012340)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0036135 DRSC - Results from RNAi screens. • FBgn0036135 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036135 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7636-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036135 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39253 InParanoid A subset of ortholog calls from InParanoid. • AAEL000210-PA Aedes aegypti (mosquito) AGAP010450-PA Anopheles gambiae (mosquito) XP_625019.1 Apis mellifera (honey bee) XP_001952518.1 Acyrthosiphon pisum (pea aphid) 283896 Branchiostoma floridae (lancelet) XP_001893685.1 Brugia malayi (roundworm nematode) BGIBMGA001500-PA Bombyx mori (silk worm) ENSBTAP00000016951 Bos taurus (bovine) CN28931 Caenorhabditis brenneri (small nematode) CBP12640 Caenorhabditis briggsae (nematode) CE34320 Caenorhabditis elegans (worm) ENSCAFP00000002594 Canis familiaris (dog) ENSCINP00000010033 Ciona intestinalis (sea squirt) CMP277C Cyanidioschyzon merolae (red alga) CPIJ008796 Culex pipens (mosquito) ENSCPOP00000020146 Cavia porcellus (guinea pig) RP03126 Caenorhabditis remanei (nematode) ENSCSAVP00000009726 Ciona savignyi (sedentary tunicate) 159292 Capitella spl (polychaete worm) DEHA2E05478g Debaryomyces Hansenii (yeast) 307116 Daphnia pulex (daphnia) ENSDARP00000085077 Danio rerio (zebra fish) ENSECAP00000017830 Equus caballus (horse) ENSGACP00000005403 Gymnopilus aculeatus (mushroom) ENSGALP00000013983 Gallus gallus (chicken) 185933 Hypsipyla robusta (cedar shoot borer) ENSP00000373404 Homo sapiens (human) ISCW005878-PA Ixodes scapularis (deer tick) 213398 Lottia gigantea (owl limpet) ENSMODP00000023698 Monodelphis domestica (gray opossum) ENSMMUP00000033665 Macaca mulatta (rhesus monkey) ENSMUSP00000002844 Mus musculus (house mouse) 35830 Nematostella vectensis (starlet anemone) XP_001601775.1 Nasonia vitripennis (wasp) ENSOANP00000013436 Ornithorynchus anatinus (platypus) ENSORLP00000016135 Oryzias latipes (japanese killifish) 30408 Ostreococcus tauri (green alga) PHUM011218-PA Pediculus humanus (human body louse) PP01299 Pristionchus pacificus (nematode) ENSPPYP00000018600 Pongo pygmaeus (orangutan) ENSPTRP00000046533 Pan troglodytes (chimpanzee) ENSRNOP00000024380 Rattus norvegicus (norway rat) Smp_151770 Schistosoma mansoni (trematode parasite) XP_789607.2 Strongylocentrotus purpuratus (purple sea urchin) 26453 Trichoplax adhaerens (metazoa) XP_972108.1 Tribolium castaneum (red flour beetle) ENSTNIP00000016419 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000002152 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39253 modMine - Data generated by the modENCODE project. • FBgn0036135 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12625 LH21170 ISCW005878 FBgn0239036 FBgn0222333 FBgn0201243 FBgn0185971 FBgn0180112 JGI_V11_307116 FBgn0080491 FBgn0160433 FBgn0136439 FBgn0124401 FBgn0107731 FBgn0102236 CPIJ008796 BGIBMGA001500 ACYPI009104 GB14941 AGAP010450 AAEL000210 PB25789 PHUM588770 GLEAN_00434
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	CG7636 (Suzuki et al., 2001, Keleman et al., 2009.8.5, Marygold et al., 2007) L2 (Suzuki et al., 2001) mRpL2 (Marygold et al., 2007)
Name Synonym	mitochondrial ribosomal protein L2 (Suzuki et al., 2001)
Secondary FlyBase IDs
References ( 13 )
Research paper	Casad et al., 2011, Genetics 189(3): 861--870 Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591] Marygold et al., 2007, Genome Biol. 8(10): R216 The ribosomal protein genes and Minute loci of Drosophila melanogaster. [FBrf0205398] Suzuki et al., 2001, J. Biol. Chem. 276(24): 21724--21736 Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. [FBrf0136752]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518]
Personal communication to FlyBase	Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078]
Curated genome annotation	Ashburner, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126651]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]