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Gene Dmel\wls

General Information
Symbol	Dmel\wls	Species	D. melanogaster
Name	wntless	Annotation symbol	CG6210
Feature type	protein_coding_gene	FlyBase ID	FBgn0036141
Gene Model Status	Current	Stock availability	9 publicly available
Also Known As	Evi, srt, Evi/Wls, Wls/Evi
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	68A9-68A9	Sequence location	3L:11,159,720..11,162,725 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene wntless is referred to in FlyBase by the symbol Dmel\wls (CG6210, FBgn0036141). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: Wnt-protein binding. There is experimental evidence for 11 unique biological process terms, many of which group under: single-organism developmental process; biological regulation; post-embryonic organ morphogenesis; regionalization; regulation of transport; appendage development; instar larval or pupal morphogenesis; positive regulation of biological process; sensory organ development; nitrogen compound transport. 27 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; leg; eye; ovary; wing margin bristle; testis; adult antennal segment; mesothoracic tergum; wing; arista. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein wntless. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval salivary gland, adult ovary, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1626719_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of wls. Gene sequence location is 3L:11159720..11162725.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 68A9-68A9   Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\wls for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wls-RA FBtr0076218  NM_140188   2574   594 wls-RB FBtr0076219  NM_168450   2478   562
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wls-PA   FBpp0075947   67.9   594   6.67     NP_648445   AAF50085 wls-PB   FBpp0075948   64.1   562   6.63     NP_729681   AAN11905
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein wntless (IPR009551)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142249   AA142250   AA201466   AA540732   AA696803   AA940617   AA942488   AA949124   AA949410   AA949493   AA950217   AA950757   AA990637   AE014296 AAF50085   AE014296 AAN11905   AI062576   AI134968   AI259129   AI294162   AI294966   AI456471   AI511695   AI513125   AI515248   AI515286   AI516695   AI519456   AI519846   AY060600 AAL28148   BG636859   BG636975   BG639051   BI165945   BI168760   BI169523   BI169867   BI215641   BI227517   BI232131   BI234386   BI234395   BI237479   BI238628   BI242997   BI243631   BI367499   BI367514   BI370425   BI374370   BI611098   BI611102   BI621815   BP552894   BP552895   BZ748840   CK661425   CL868466   CO189284   CO291950   CO298737   CO300139   CO320786   CO326493   CS423598   CS423604   CZ470346   CZ470581   CZ470584   DQ305404 ABD58936   EC052458   EC055240   EC062702   EC216132   EC223934   EC229368   EV592575   GH941358   GH941848   GH943344   GH943645   GH944415   GH944437   GH946092   GH946507   GH946601   GH946732   GH947947   GH948428   GH948491   GH948882   GH948914   GH949684   GH949693   GH949769   GH950777   GH951381   GH951383   GH952589   GH953551   GH954340   GH955057   GH955284   GH955524   GH956987   GH958078   GH958083   GH960048   GH961517   GH962120   GH962291   GH962861   GH963760   GH964035   GH965354   GH965919   GH965950   GH967214   GH967427   GH968374   GH968858   GH969231   GH970122   GH970217   GH970481   GH971342   GH971901   GH972877   GH973338   GH973462   GH973527   GH975182   GH976327   GH977491   GH978184   GH978411   GH979150   GH979240   GH979486   GH979969   GH980652   GH981769   GH982058   GH982710   GH982741   GH983802   GH983848   GH984207
UniProtKB/Swiss-Prot	Q95ST2
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   cardiogenic mesoderm   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   circular visceral muscle fiber   (Fisher et al., 2012) embryonic brain   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval pericardial cell   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
early endosome inferred from direct assay (Belenkaya et al., 2008) extracellular vesicular exosome inferred from direct assay (Koles et al., 2012) Golgi apparatus inferred from direct assay (Port et al., 2008) integral to synaptic vesicle membrane inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009) multivesicular body inferred from direct assay (Koles et al., 2012) neuromuscular junction inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009) plasma membrane inferred from direct assay (Bartscherer et al., 2006, Port et al., 2008, Belenkaya et al., 2008) postsynaptic membrane inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009) presynaptic membrane inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval salivary gland, adult ovary, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland    1076.9 Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (568.825) Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland  (1076.9) Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland  1076.9 Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland    1076.9 Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland    1076.9 Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland  (1076.9) Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland  1076.9 Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    568.825 Larval Midgut    171.9 Larval Hindgut    205.7 Larval Malpighian Tubules    360.3 Larval Fat Body    66.1 Larval Salivary Gland    298.4 Larval Trachea    85.85 Larval Carcass    144.475 Adult Head    140.3 Adult Eye    91.6 Adult Brain    305.6 Adult Thoracic-Abdominal Ganglion    274.1 Adult Crop    249.6 Adult Midgut    180.7 Adult Hindgut    188.5 Adult Malpighian Tubules    205.3 Adult Fat Body    39.2 Adult Salivary Gland    1076.9 Adult Heart    137.825 Adult VirginFemale Spermatheca    61.5 Adult InseminatedFemale Spermatheca    83.7 Adult Ovary    426.4 Adult Testis    111.7 Adult Male Accessory Gland    129.5 Adult Carcass    62 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    140.3   NA  Eye    91.6   NA  Brain    305.6   568.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    274.1   NA  Crop    249.6   171.9  Midgut    180.7   205.7  Hindgut    188.5   360.3  Malpighian Tubules    205.3   66.1  Fat Body    39.2   298.4  Salivary Gland    1076.9   NA  Heart    137.825   85.85  Trachea    NA   NA  VirginFemale Spermatheca    61.5   NA  InseminatedFemale Spermatheca    83.7   NA  Ovary    426.4   NA  Testis    111.7   NA  Male Accessory Gland    129.5   144.475  Carcass    62 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3  (27) central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female  (30) ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3  27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female  30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    22 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    3 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    3 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    5 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    7 digestive system, larvae L3 wandering    10 digestive system, 1-day adult    4 digestive system, 4-day adult    5 digestive system, 20-day adult    5 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    9 carcass, larvae L3 wandering    13 carcass, 1-day adult    2 carcass, 4-day adult    3 carcass, 20-day adult    3 ovary, virgin 4-day female    30 ovary, mated 4-day female    25 testis, mated 4-day male    4 accessory gland, mated 4-day male    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    125 embryo 04-06hr    151 embryo 06-08hr    100 embryo 08-10hr    88 embryo 10-12hr    62 embryo 12-14hr    45 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    20 embryo 20-22hr    39 embryo 22-24hr    34 larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    29 white prepupae new    31 white prepupae 12hr    33 white prepupae 24hr    47 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day    37 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (72) embryo 02-04hr  (125) embryo 04-06hr  (151) embryo 06-08hr  (100) embryo 08-10hr  (88) embryo 10-12hr  (62) embryo 12-14hr  (45) embryo 14-16hr  (46) embryo 16-18hr  (35) embryo 18-20hr    20 embryo 20-22hr  (39) embryo 22-24hr  (34) larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  (29) white prepupae new  (31) white prepupae 12hr  (33) white prepupae 24hr  (47) pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day  (37) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr  (125) embryo 04-06hr  (151) embryo 06-08hr    100 embryo 08-10hr    88 embryo 10-12hr    62 embryo 12-14hr    45 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    20 embryo 20-22hr    39 embryo 22-24hr    34 larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    29 white prepupae new    31 white prepupae 12hr    33 white prepupae 24hr    47 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day    37 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    125 embryo 04-06hr    151 embryo 06-08hr    100 embryo 08-10hr    88 embryo 10-12hr    62 embryo 12-14hr    45 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    20 embryo 20-22hr    39 embryo 22-24hr    34 larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    29 white prepupae new    31 white prepupae 12hr    33 white prepupae 24hr    47 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day    37 adult female 30day    37 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    125 embryo 04-06hr    151 embryo 06-08hr    100 embryo 08-10hr    88 embryo 10-12hr    62 embryo 12-14hr    45 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    20 embryo 20-22hr    39 embryo 22-24hr    34 larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    29 white prepupae new    31 white prepupae 12hr    33 white prepupae 24hr    47 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day    37 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (72) embryo 02-04hr  (125) embryo 04-06hr  (151) embryo 06-08hr  (100) embryo 08-10hr  (88) embryo 10-12hr  (62) embryo 12-14hr  (45) embryo 14-16hr  (46) embryo 16-18hr  (35) embryo 18-20hr    20 embryo 20-22hr  (39) embryo 22-24hr  (34) larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  29 white prepupae new  31 white prepupae 12hr  (33) white prepupae 24hr  (47) pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day  (37) adult female 30day  (37) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr  125 embryo 04-06hr  (151) embryo 06-08hr    100 embryo 08-10hr    88 embryo 10-12hr    62 embryo 12-14hr    45 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    20 embryo 20-22hr    39 embryo 22-24hr    34 larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    29 white prepupae new    31 white prepupae 12hr    33 white prepupae 24hr    47 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day    37 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    72 embryo 02-04hr    125 embryo 04-06hr    151 embryo 06-08hr    100 embryo 08-10hr    88 embryo 10-12hr    62 embryo 12-14hr    45 embryo 14-16hr    46 embryo 16-18hr    35 embryo 18-20hr    20 embryo 20-22hr    39 embryo 22-24hr    34 larva L1    12 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    29 white prepupae new    31 white prepupae 12hr    33 white prepupae 24hr    47 pupae 2d postWPP    21 pupae 3d postWPP    9 pupae 4d postWPP    9 adult male 01day    8 adult male 05day    10 adult male 30day    11 adult female 01day    24 adult female 05day    37 adult female 30day    37 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    45 Schneider line 2 Sg4    49 embryonic 1182-4H    26 embryonic GM2    17 embryonic Kc167    35 embryonic S1    6 embryonic S3    31 leg disc CME L1    24 wing disc CME-W2    46 wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    29 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (45) Schneider line 2 Sg4  (49) embryonic 1182-4H  26 embryonic GM2    17 embryonic Kc167  (35) embryonic S1    6 embryonic S3  (31) leg disc CME L1    24 wing disc CME-W2  (46) wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3  (27) wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (69) eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5  (37) mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2  (29) ovary fGS/OSS    16 ovary OSC  26 ovary OSS  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    45 Schneider line 2 Sg4    49 embryonic 1182-4H    26 embryonic GM2    17 embryonic Kc167    35 embryonic S1    6 embryonic S3    31 leg disc CME L1    24 wing disc CME-W2    46 wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    29 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    45 Schneider line 2 Sg4    49 embryonic 1182-4H    26 embryonic GM2    17 embryonic Kc167    35 embryonic S1    6 embryonic S3    31 leg disc CME L1    24 wing disc CME-W2    46 wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    29 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    45 Schneider line 2 Sg4    49 embryonic 1182-4H    26 embryonic GM2    17 embryonic Kc167    35 embryonic S1    6 embryonic S3    31 leg disc CME L1    24 wing disc CME-W2    46 wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    29 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (45) Schneider line 2 Sg4  (49) embryonic 1182-4H  26 embryonic GM2    17 embryonic Kc167  (35) embryonic S1    6 embryonic S3  31 leg disc CME L1    24 wing disc CME-W2  (46) wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3  27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3  (69) eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5  (37) mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2  29 ovary fGS/OSS    16 ovary OSC  26 ovary OSS  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    45 Schneider line 2 Sg4    49 embryonic 1182-4H    26 embryonic GM2    17 embryonic Kc167    35 embryonic S1    6 embryonic S3    31 leg disc CME L1    24 wing disc CME-W2    46 wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    29 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    45 Schneider line 2 Sg4    49 embryonic 1182-4H    26 embryonic GM2    17 embryonic Kc167    35 embryonic S1    6 embryonic S3    31 leg disc CME L1    24 wing disc CME-W2    46 wing disc ML-DmD8    19 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    27 wing disc ML-DmD21    22 wing disc ML-DmD32    17 haltere disc ML-DmD17-c3    69 eye-antennal disc ML-DmD11    17 antennal disc ML-DmD20-c5    37 mixed discs ML-DmD4-c1    11 CNS ML-DmBG1-c1    23 CNS ML-DmBG2-c2    22 tumorous blood cells mbn2    29 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    9 cold shock, 4-day adult    6 heat shock, 4-day adult    11 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    10 Cadmium 50 mM 48 hrs, 4-day adult    11 Cadmium 100 mM 48 hrs, 4-day adult    18 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    14 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    6 Ethanol 2.5% 3 hrs, larvae L3    23 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    17 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    13 Paraquat 10 mM 48 hrs, 4-day adult    17 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • GH01813 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036141 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6210-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for wls Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal wls1 lethal | embryonic stage | germline clone, with wls7E4 wlsdsRNA.cGa lethal | embryonic stage | germline clone, with wlsdsRNA.cGa wls7E4 lethal | embryonic stage | germline clone (with wls7E4) wlsdsRNA.cGa lethal | embryonic stage | germline clone (with wlsdsRNA.cGa) wls7E4 lethal | embryonic stage | germline clone | rescuable maternal effect wls7E4 lethal | embryonic stage | maternal effect | segment polarity expression pattern wlsevi-2 lethal | pharate adult stage (with wls1) wls2 lethal | pharate adult stage (with wls2) wls1 lethal | pupal stage wlsevi-2 lethal | pupal stage (with Df(3L)vin5) wls7E4 viable wlsEY11001 viable, with Scer\GAL4pnr-MD237 wlsGD2418 Sterility Allele female sterile, with Scer\GAL4wg-ND382, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 female sterile, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 female sterile, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 female sterile, with Scer\GAL4wg-S180, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 female sterile, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 female sterile, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 female sterile (with wls1), with Scer\GAL4wg-ND382, wls2 wlsScer\UAS.T:Ivir\HA1 female sterile (with wls1), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls2 female sterile (with wls1), with Scer\GAL4wg-S180, wls2 wlsScer\UAS.T:Ivir\HA1 female sterile (with wls1), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls2 female sterile (with wls2), with Scer\GAL4wg-ND382, wls1 wlsScer\UAS.T:Ivir\HA1 female sterile (with wls2), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls1 female sterile (with wls2), with Scer\GAL4wg-S180, wls1 wlsScer\UAS.T:Ivir\HA1 female sterile (with wls2), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls1 female sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls1 wls2 female sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls2 wls1 female sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls1 wls2 female sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls2 wls1 fertile wlsEY11001 male sterile, with Scer\GAL4wg-ND382, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 male sterile, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 male sterile, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 male sterile, with Scer\GAL4wg-S180, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 male sterile, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 male sterile, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 male sterile (with wls1), with Scer\GAL4wg-ND382, wls2 wlsScer\UAS.T:Ivir\HA1 male sterile (with wls1), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls2 male sterile (with wls1), with Scer\GAL4wg-S180, wls2 wlsScer\UAS.T:Ivir\HA1 male sterile (with wls1), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls2 male sterile (with wls2), with Scer\GAL4wg-ND382, wls1 wlsScer\UAS.T:Ivir\HA1 male sterile (with wls2), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls1 male sterile (with wls2), with Scer\GAL4wg-S180, wls1 wlsScer\UAS.T:Ivir\HA1 male sterile (with wls2), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls1 male sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls1 wls2 male sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls2 wls1 male sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls1 wls2 male sterile (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls2 wls1 Other Phenotypes Allele visible | homeotic (with wls1) wls2 visible | homeotic (with wls2) wls1 Phenotype manifest in Allele adult antennal segment (with wls1) wls2 adult antennal segment (with wls2) wls1 arista (with wls1) wls2 arista (with wls2) wls1 denticle belt | maternal effect | supernumerary wls2 embryonic/first instar larval cuticle | germline clone, with wls7E4 wlsdsRNA.cGa embryonic/first instar larval cuticle | germline clone, with wlsdsRNA.cGa wls7E4 embryonic/first instar larval cuticle | germline clone (with Df(3L)vin5) wls7E4 embryonic/first instar larval cuticle | germline clone (with wls7E4) wlsdsRNA.cGa embryonic/first instar larval cuticle | germline clone (with wlsdsRNA.cGa) wls7E4 embryonic/first instar larval cuticle | germline clone | rescuable maternal effect wls7E4 eye wlsevi-2 larva | maternal effect | segment polarity expression pattern wls2 leg wlsevi-2 leg (with wls1) wls2 leg (with wls2) wls1 mesothoracic tergum (with wls1) wls2 mesothoracic tergum (with wls2) wls1 ovary, with Scer\GAL4wg-ND382, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 ovary, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 ovary, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 ovary, with Scer\GAL4wg-S180, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 ovary, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 ovary, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 ovary (with wls1), with Scer\GAL4wg-ND382, wls2 wlsScer\UAS.T:Ivir\HA1 ovary (with wls1), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls2 ovary (with wls1), with Scer\GAL4wg-S180, wls2 wlsScer\UAS.T:Ivir\HA1 ovary (with wls1), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls2 ovary (with wls2), with Scer\GAL4wg-ND382, wls1 wlsScer\UAS.T:Ivir\HA1 ovary (with wls2), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls1 ovary (with wls2), with Scer\GAL4wg-S180, wls1 wlsScer\UAS.T:Ivir\HA1 ovary (with wls2), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls1 ovary (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls1 wls2 ovary (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls2 wls1 ovary (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls1 wls2 ovary (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls2 wls1 testis, with Scer\GAL4wg-ND382, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 testis, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 testis, with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 testis, with Scer\GAL4wg-S180, wls2/wls1 wlsScer\UAS.T:Ivir\HA1 testis, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls1 wls2 testis, with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1/wls2 wls1 testis (with wls1), with Scer\GAL4wg-ND382, wls2 wlsScer\UAS.T:Ivir\HA1 testis (with wls1), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls2 testis (with wls1), with Scer\GAL4wg-S180, wls2 wlsScer\UAS.T:Ivir\HA1 testis (with wls1), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls2 testis (with wls2), with Scer\GAL4wg-ND382, wls1 wlsScer\UAS.T:Ivir\HA1 testis (with wls2), with Scer\GAL4wg-ND382, wlsScer\UAS.T:Ivir\HA1 wls1 testis (with wls2), with Scer\GAL4wg-S180, wls1 wlsScer\UAS.T:Ivir\HA1 testis (with wls2), with Scer\GAL4wg-S180, wlsScer\UAS.T:Ivir\HA1 wls1 testis (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls1 wls2 testis (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-ND382, wls2 wls1 testis (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls1 wls2 testis (with wlsScer\UAS.T:Ivir\HA1), with Scer\GAL4wg-S180, wls2 wls1 wing wlsEY01593 wing, with wls1 wlst.AEGL wing, with wlst.AEGL wls1 wing (with Df(3L)lxd6) wlsEY01593 wing (with wls1) wls2 wlst.AEGL wing (with wls2) wls1 wing (with wlst.AEGL) wls1 wing margin, with wls1 wlst.AEGL wing margin, with wlst.AEGL wls1 wing margin (with wls1) wlst.AEGL wing margin (with wlst.AEGL) wls1 wing margin | somatic clone (with wls1) wls2 wing margin | somatic clone (with wls2) wls1 wing margin bristle wlsEY01593 wing margin bristle, with wls1 wlst.AEGL wing margin bristle, with wlst.AEGL wls1 wing margin bristle (with Df(3L)lxd6) wlsEY01593 wing margin bristle (with wls1) wlst.AEGL wing margin bristle (with wlst.AEGL) wls1 wing margin bristle | somatic clone wls7E4 wing vein L1 | somatic clone wls7E4
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of wls Class Mutagen Stocks Known lesion wlsc06300 piggyBac transposase 2 -- wlsc05902 piggyBac transposase 1 -- wlsc06303 piggyBac transposase 1 -- wlsEY01593 P-element activity 1 Yes wlsEY11001 P-element activity 1 -- wls01593-1 P-element activity 0 Yes wls1 ethyl methanesulfonate 0 Yes wls2 ethyl methanesulfonate 0 Yes wls7E4 loss of function allele ethyl methanesulfonate 0 Yes wlsevi-2 loss of function allele Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wls Class Mutagen Stocks Known lesion wlsGD2418 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes wlsKK101700 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wls+tGa in vitro construct - genomic fragment 0 Yes wlsAct5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion 0 Yes wlsdsRNA.cGa in vitro construct - RNAi 0 Yes wlshs.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes wlsScer\UAS.cBa.T:Ivir\HA1 0 Yes wlsScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes wlsScer\UAS.cKa.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes wlsScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion 0 Yes wlsScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes wlsScer\UAS.T:SV5\V5.cBa in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes wlsScer\UAS.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes wlst.AEGL in vitro construct - genomic fragment in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes wlsαTub84B.PB in vitro construct - regulatory fusion 0 Yes wlsαTub84B.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes wlsΔ1.T:Ecol\lacZ in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)lxd6 (Bartscherer et al., 2006) Df(3L)vin5 (Goodman et al., 2006)
Not disrupted in	Df(3L)ED4457 (Goodman et al., 2006) Df(3L)vin4 (Goodman et al., 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2418} NA P{KK101700} NA P{UAS-evi.EGFP} NA P{UAS-evi.HA.K} NA P{UAS-wls.HA} NA P{UAS-wls.V5} NA reporter construct P{wls-lacZ.H} No characterization construct P{αTub84B-srt.B} NA P{αTub84B-srt.HA} NA PBac{wls.G} NA PBac{wls.Y435A} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}wlsEY01593 NA P{EPgy2}wlsEY11001 NA miscellaneous insertions PBac{PB}wlsc05902 NA PBac{PB}wlsc06300 NA PBac{PB}wlsc06303 NA
Gene Ontology: Function, Process & Cellular Component ( 21 unique terms )
Terms Based on Experimental Evidence ( 21 terms )
Molecular Function
CV term Evidence References
Wnt-protein binding inferred from physical interaction with UniProtKB:P09615 (assigned by UniProtKB) (Franch-Marro et al., 2008)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from mutant phenotype (Bartscherer et al., 2006) cuticle pattern formation inferred from mutant phenotype (Goodman et al., 2006) imaginal disc-derived leg morphogenesis inferred from mutant phenotype (Bartscherer et al., 2006) imaginal disc-derived wing margin morphogenesis inferred from mutant phenotype (Goodman et al., 2006) inferred from mutant phenotype (assigned by UniProtKB) (Banziger et al., 2006) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Bartscherer et al., 2006) peptide secretion inferred from mutant phenotype (Goodman et al., 2006) positive regulation of protein secretion inferred from mutant phenotype (assigned by UniProtKB) (Franch-Marro et al., 2008) positive regulation of Wnt receptor signaling pathway inferred from mutant phenotype (assigned by UniProtKB) (Banziger et al., 2006, Franch-Marro et al., 2008) regulation of intracellular protein transport inferred from mutant phenotype (assigned by UniProtKB) (Franch-Marro et al., 2008) segment polarity determination inferred from mutant phenotype (Bartscherer et al., 2006) inferred from mutant phenotype (assigned by UniProtKB) (Banziger et al., 2006) Wnt receptor signaling pathway inferred from mutant phenotype (Goodman et al., 2006)
Cellular Component
CV term Evidence References
early endosome inferred from direct assay (Belenkaya et al., 2008) extracellular vesicular exosome inferred from direct assay (Koles et al., 2012) Golgi apparatus inferred from direct assay (Port et al., 2008) integral to synaptic vesicle membrane inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009) multivesicular body inferred from direct assay (Koles et al., 2012) neuromuscular junction inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009) plasma membrane inferred from direct assay (Bartscherer et al., 2006, Port et al., 2008, Belenkaya et al., 2008) postsynaptic membrane inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009) presynaptic membrane inferred from direct assay (assigned by UniProtKB) (Korkut et al., 2009)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
wls - ATPsyn-Cf6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG11857 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG3164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG32138 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG5447 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) wls - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - CG7668 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Cctγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Hel25E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - ImpL3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Kr-h2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - MRP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Oscp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Ostγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Pvr anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - RpS19a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Sc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Shc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Snx3 anti tag coimmunoprecipitation, anti tag western blot (Zhang et al., 2011) wls - Surf4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Syb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Tcp-1ζ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - Thiolase anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - l(1)G0156 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - l(1)G0230 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - l(2)03709 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) wls - porin anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wls allele Gene References unspecified wg (Banziger et al., 2006)
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036141 DroID - A comprehensive database of gene and protein interactions. • FBgn0036141
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67DB1R Dipteran inclusive ortholog search EOG6K3M4K Insect inclusive ortholog search EOG6PK143 Arthropod inclusive ortholog search EOG6JH9WZ Metazoa inclusive ortholog search EOG6WQCVT
Orthologs in Drosophila Species (EOG67DB1R)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\wls     Drosophila simulans   Dsim\GD12816 Y   Drosophila sechellia   Dsec\GM24767 Y   Drosophila erecta   Dere\GG13932 Y   Drosophila yakuba   Dyak\GE20230 Y   Drosophila ananassae   Dana\GF24563 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA19442 Y   Drosophila persimilis   Dper\GL22839 Y   Drosophila willistoni   Dwil\GK20551 Y   Drosophila virilis   Dvir\GJ11298 Y   Drosophila mojavensis   Dmoj\GI11620 Y   Drosophila grimshawi   Dgri\GH16661 Y
Orthologs in non-Drosophila Dipterans (EOG6K3M4K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007842   Anopheles gambiae Malaria mosquito  Agam\AGAP007896   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801776
Orthologs in non-Dipteran Insects (EOG6PK143)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46580   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009388   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24785   Atta cephalotes Leafcutter ant  Acep\ACEP20534   Camponotus floridanus Florida carpenter ant  Cflo\CFLO21716   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21324   Linepithema humile Argentine ant  Lhum\LH16472   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17340   Solenopsis invicta Red fire ant  Sinv\SINV25983   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006991   Bombyx mori Silkmoth  Bmor\BGIBMGA004442   Pediculus humanus Human body louse  Phum\PHUM522700   Tribolium castaneum Red flour beetle  Tcas\TC005345
Orthologs in non-Insect Arthropods (EOG6JH9WZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_209466   Daphnia pulex Water flea  Dpux\JGI_V11_314673   Ixodes scapularis Deer tick  Isca\ISCW012548
Orthologs in non-Arthropod Metazoa (EOG6WQCVT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\mig-14   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007860gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020476gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018886gn   Danio rerio Zebrafish  Drer\wls   Xenopus tropicalis Western clawed frog  Xtro\wls   Gallus gallus Domestic chicken  Ggal\GPR177   Mus musculus House mouse  Mmus\Wls   Rattus norvegicus Norway rat  Rnor\Wls   Homo sapiens Human  Hsap\ENSG00000116729
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000116729
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12816 Drosophila sechellia Dsec\GM24767 Drosophila erecta Dere\GG13932 Drosophila yakuba Dyak\GE20230 Drosophila ananassae Dana\GF24563 Drosophila pseudoobscura pseudoobscura Dpse\GA19442 Drosophila persimilis Dper\GL22839 Drosophila willistoni Dwil\GK20551 Drosophila virilis Dvir\GJ11298 Drosophila mojavensis Dmoj\GI11620 Drosophila grimshawi Dgri\GH16661
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	15363 y1 w67c23; P{EPgy2}wlsEY01593 20651 y1 w67c23; P{EPgy2}wlsEY11001 17756 w1118; PBac{PB}wlsc06300/TM6B, Tb1
Harvard	- PBac{PB}wlsc05902 - PBac{PB}wlsc06300 - PBac{PB}wlsc06303
VDRC	v103812 P{KK101700}VIE-260B v5214 w1118; P{GD2418}v5214 v5215 w1118; P{GD2418}v5215
Genomic Clones ( 1 )
	BACR19G23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 134 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01813
Other clones	DPiM_GH01813
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12567 GM08429 LD04485 LD20522 LD21883 LD26733 LD27902 LD28302 LD30181 LD30868 LD34438 LD36503 LD39061 LD39669 LD42654 LD42673 LD43180 LD46987 LD47043 LP02472 LP07474 LP08462 LP20944 RE05948 RE09626 RE10722 RE11172 RE22215 RE24588 RE28148 RE30077 RE30087 RE33714 RE35132 RE40520 RE41329 RE53273 RE53291 RE56934 RE61940 RH17216 RH17220 RH53231 SD14680 SD14817
Other clones	57350 69734 183236 CK01.27B.H1 CK00022 Dmel_neb_012013_0610_1865 EC052458 EC055240 EK043761 EK173719 EK177454 EK198842 EK288129 EP04017 FGM221D08 LD29521 RP004042549 RP004043285 RP004067443 RP004095910 RP004100101 RP004103978 RP004115570 RP004127518 RP004142158 RP004164349 RP004165709 RP004165724 RP004180072 RP004180425 RP004181571 RP004192532 RP004193461 RP004195867 RP004198855 RP004200612 RP004203648 RP004204785 RP004206990 RP004217440 RP004217732 RP004218005 RP004218972 RP004219642 RP004224652 RP004225192 RP004228031 RP004239040 RP004241254 RP004241614 RP004246093 RP004248444 RP004249811 RP004252214 RP004253247 RP004253286 RP004260252 RP004262249 RP004263096 RP004269715 RP004289800 RP004321971 RP004348564 RP004380177 RP004381146 RP004383628 RP004390009 RP004405710 RP004414614 RP004426307 RP004429948 RP004431551 RP004444207 RP004449442 RP004456088 RP004467451 RP004470167 RP004485661 RP004485826 RP004492250 RP004508290 RP004511869 RP004520750 RP004527177 RP004527813 RP004534475 RP004549875
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0036141 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39259
Antibody Information
	polyclonal (Port et al., 2008, Korkut et al., 2009, Zhang et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: srt CG6210 (Selva, 2006.3.6) Source for identity of: wls CG6210 (Banziger, 2006.2.28)
Source for database merge of
Additional comments
Other Comments
	wg protein secretion requires endosome-to-Golgi retrieval of wls protein by the retromer complex. (Franch-Marro et al., 2008) wls protein accumulates in the Golgi apparatus of wg-producing cells, and this localisation is essential for wg protein secretion. wls protein localisation and levels critically depend on the retromer complex. (Port et al., 2008) srt is only required in cells that synthesise wg. (Baenziger et al., 2006) Mutation of srt leads to an accumulation of wg protein within cells that synthesise wg. (Baenziger et al., 2006) dsRNA made from templates generated with primers against the 3' UTR and against the ORF of this gene. (Bartscherer et al., 2006) Epistasis experiments show that srt acts upstream of arr and dsh. (Bartscherer et al., 2006) srt is required for secretion of wg from cells. (Bartscherer et al., 2006) Mutations in srt prevent the secretion of active wg ligand in signal sending cells; comparable levels of wg protein are present outside of srt mutant and wild-type cells, however, wg protein produced in srt mutant cells cannot be taken up into endocytic vesicles in receiving cells. (Selva et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140188 NM_168450 RefSeq (Proteins) • NP_648445 NP_729681 DDBJ / EMBL / GenBank • AAF50085 AAL28148 AAN11905 ABD58936 AI062576 AI513125 AY060600 BZ748840 CL868466 CS423598 CS423604 CZ470346 CZ470581 CZ470584 DQ305404 Entrez Gene - A searchable database of RefSeq genes. • 39259 UniProtKB/Swiss-Prot • Q95ST2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein wntless (IPR009551) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH01813
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0036141 DroID - A comprehensive database of gene and protein interactions. • FBgn0036141 DRSC - Results from RNAi screens. • FBgn0036141 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0036141 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6210-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0036141 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39259 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/wntless.htm modMine - Data generated by the modENCODE project. • FBgn0036141
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG6210 (Goodman et al., 2006, Banziger, 2006.2.28, Banziger et al., 2006, Bartscherer et al., 2006, Svensson et al., 2007, Schiess et al., 2009, Franch-Marro et al., 2008, Keleman et al., 2009.8.5) Evi (Coudreuse and Korswagen, 2007, Perrimon and Mathey-Prevot, 2007, Buechling et al., 2008, Lin et al., 2008, Koles et al., 2012, Belenkaya et al., 2008, Buechling et al., 2011) evi (Clevers, 2006, Bartscherer et al., 2006, Chin and Yeston, 2006, Bartscherer et al., 2007, Tountas and Fortini, 2007, Ching and Nusse, 2006, Korkut et al., 2009, Buechling et al., 2010, Gross et al., 2012) Evi/Wls (Bartscherer et al., 2007, Bartscherer et al., 2006) srt (Goodman et al., 2006, ) Srt (Belenkaya et al., 2008) Wls (Aikin et al., 2012, Coudreuse and Korswagen, 2007, Buechling et al., 2008, Lin et al., 2008, Harterink et al., 2011, Tang et al., 2012) wls (Banziger, 2006.2.28, Baenziger et al., 2006, Soldini et al., 2005.11.27, He and Axelrod, 2006, Clevers, 2006, Banziger et al., 2006, Bartscherer et al., 2006, Chin and Yeston, 2006, Tountas and Fortini, 2007, Herr and Basler, 2012, Ching and Nusse, 2006, Ching et al., 2008, Port et al., 2008, Franch-Marro et al., 2008, Kennell et al., 2008, Belenkaya et al., 2008, Port et al., 2011, Zhang et al., 2011, Gasnereau et al., 2011) Wls/Evi (Banziger et al., 2006) wls/evi (Ching and Nusse, 2006)
Name Synonym	Evenness interrupted (Bartscherer et al., 2007, Bartscherer et al., 2007) evenness interrupted (Clevers, 2006, Tountas and Fortini, 2007, Ching and Nusse, 2006) Evenness Interrupted (Lin et al., 2008, Belenkaya et al., 2008) sprinter (Goodman et al., 2006, Selva, 2006.3.6, Selva et al., 2006) Sprinter (Lin et al., 2008, Belenkaya et al., 2008) wntless (Banziger, 2006.2.28, Baenziger et al., 2006, Soldini et al., 2005.11.27, He and Axelrod, 2006, Clevers, 2006, Banziger et al., 2006, Tountas and Fortini, 2007, Ching and Nusse, 2006, Franch-Marro et al., 2008, Port et al., 2011, Gasnereau et al., 2011) Wntless (Coudreuse and Korswagen, 2007, Lin et al., 2008, Belenkaya et al., 2008, Port et al., 2008)
Secondary FlyBase IDs
References ( 51 )
Generate a list of	All references relating to this gene ( 51 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 4 ) Review  ( 5 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Conference report  ( 2 ) Website  ( 1 )
Recent research papers ( 10 )
	Aikin et al., 2012, PLoS ONE 7(3): e33665 A Genome-Wide RNAi Screen Identifies Regulators of Cholesterol-Modified Hedgehog Secretion in Drosophila. [FBrf0217808] Gross et al., 2012, Nat. Cell Biol. 14(10): 1036--1045 Active Wnt proteins are secreted on exosomes. [FBrf0219521] Herr and Basler, 2012, Dev. Biol. 361(2): 392--402 Porcupine-mediated lipidation is required for Wnt recognition by Wls. [FBrf0217047] Koles et al., 2012, J. Biol. Chem. 287(20): 16820--16834 Mechanism of evenness interrupted (evi)-exosome release at synaptic boutons. [FBrf0218323] Tang et al., 2012, Dev. Biol. 364(1): 32--41 Roles of N-glycosylation and lipidation in Wg secretion and signaling. [FBrf0217651] Buechling et al., 2011, EMBO Rep. 12(12): 1265--1272 p24 proteins are required for secretion of Wnt ligands. [FBrf0216831] Gasnereau et al., 2011, J. Biol. Chem. 286(50): 43324--43333 Identification of an endocytosis motif in an intracellular loop of wntless protein, essential for its recycling and the control of wnt protein signaling. [FBrf0216938] Harterink et al., 2011, Nat. Cell Biol. 13(8): 914--923 A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion. [FBrf0216275] Port et al., 2011, EMBO Rep. 12(11): 1144--1152 A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion. [FBrf0216532] Zhang et al., 2011, Cell Res. 21(12): 1677--1690 SNX3 controls Wingless/Wnt secretion through regulating retromer-dependent recycling of Wntless. [FBrf0216871] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...